Archive for May, 2014

Horizon Discoverys breathless pursuit of world leadership in personalised medicines research from its Cambridge UK headquarters has seen the business acquire more gene editing technology.

And CEO, Dr Darrin Disley said Horizon would continue to review the gene editing field for further product expansion and IP licensing opportunities.

His pledge follows a non-exclusive licence agreement with ERS Genomics Ltd a Dublin-based company to access IP relating to the CRISPR/Cas9 gene editing system.

Horizon has rights to use the technology, based on the work of globally renowned Dr Emmanuelle Charpentier - and her colleagues for a broad raft of uses.

The deal covers research applications including development and sale of research tools, kits and reagents; performance of research services; creation of genetically modified disease model cell lines; development and production of reference standard material for molecular diagnostics; internal target identification and validation research efforts.

Dr Disley believes this is a vital piece of business as Horizon expands its product suite.

The acquisition of the important CRISPR IP is in line with the companys aims outlined at the time of its IPO and further strengthens Horizons long-term position in the market for this cutting edge gene editing technology.

Access to a broader CRISPR IP portfolio will allow the technology to be deployed extensively across Horizons products, services and leveraged R & D and further enhance the attractiveness of the Horizon GENESIS offering to customers.

Dr Disley said: Horizon Discoverys ambition is to be the market leader in CRISPR technology and by expanding our portfolio of intellectual property rights in this area we aim to ensure that our customers, both now and in the future, will have unencumbered access to this innovative new gene editing technology

We believe that the ERS Genomics IP, based on the work of Dr Charpentier and her colleagues, is particularly important and so we are very pleased to be able to add it to our expanding portfolio of patent rights in this area on behalf of our customers.

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Horizon buys more gene editing jewels

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Newswise Orlando, Fla. Scientists have developed a non-invasive technique to determine if individuals carry a gene for an inherited eye disease known as retinitis pigmentosa. The research is being presented at the 2014 Annual Meeting of the Association for Research in Vision and Ophthalmology (ARVO) this week in Orlando, Fla.

The technique involves collecting a patients urine and measuring the ratio between specific compounds. The non-invasive process makes subsequent testing clinic-friendly, especially for children being screened.

Retinitis pigmentosa is a group of inherited conditions where patients progressively lose the ability to see. Development of the disease can include night blindness and tunnel vision, eventually leading to the loss of sight.

Abstract Title: Aberrant Dolichol Chain Length Distribution as Biomarkers for Retinitis Pigmentosa Associated with DHDDS Genotypes Presentation Start/End Time: Wednesday, May 7, 4pm 4:15pm Location: S 230A-D Session Number: 463

# # #

The Association for Research in Vision and Ophthalmology (ARVO) is the largest eye and vision research organization in the world. Members include some 12,000 eye and vision researchers from over 70 countries. ARVO encourages and assists research, training, publication and knowledge-sharing in vision and ophthalmology.

All abstracts accepted for presentation at the ARVO Annual Meeting represent previously unpublished data and conclusions. This research may be proprietary or may have been submitted for journal publication. Embargo policy: Journalists must seek approval from the presenter(s) before reporting data from paper or poster presentations. Press releases or stories on information presented at the ARVO Annual Meeting may not be released or published until the conclusion of the presentation.

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Non-Invasive Technique Can Identify Genetic Carriers of Eye Disease

hide captionCustomers shop for produce at the Hunger Mountain Co-op in Montpelier, Vt., in 2013.

Customers shop for produce at the Hunger Mountain Co-op in Montpelier, Vt., in 2013.

Vermont Gov. Peter Shumlin will sign a landmark bill into law on Thursday, making the state the first to require food producers to label products made with genetic engineering.

The law won't go into effect for two years, but it's already become a hot topic at the first outdoor farmers market of the season in the capital city of Montpelier.

"Finally we have a vote," says Laini Fondilier, who runs the Lazy Lady Farm stand. "We haven't been able to vote on this by our purchases."

Wayne Fawbush, a customer, says he goes out of his way to avoid buying GMO-based foods, and Fondilier chimes in, "But sometimes you don't know it's in there."

The majority of the corn, soybeans and canola grown in the United States are genetically engineered, mostly to resist certain pests or herbicides. That means most packaged food sold in this country contains products that were grown with genetic engineering.

As we reported last month, Connecticut and Maine have already passed labeling acts, but their laws only go into effect once a certain number of other states pass similar legislation.

Vermont is prepared to go first and go it alone.

The state's attorney general, Bill Sorrell, says he doesn't yet know what the label will look like, but he is sure of one thing: "I'll be very surprised if we are not sued," he says, by companies like Monsanto, the world's largest producer of genetically engineered seeds.

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Vermont's GMO Bill Expected To Face Major Legal Challenges

Scientists have created the first organism with synthetic DNA that can replicate in a cell, an achievement that promises to add new letters to the genetic code underlying life on earth.

In the natural world, just two chemical base pairs, known simply as A-T and C-G, constitute the building blocks of DNA in all life forms. Research published yesterday in the journal Nature describes the creation of a cell that contains a man-made base pair, dubbed d5SICS-dNAM.

By expanding the natural boundaries of what constitutes life, scientists hope they can one day create new proteins that can handle a variety of chores in the body, potentially leading to unique ways to attack disease. The approach is safe, the researchers said, because it includes a chemical additive that the cell needs to survive.

We created an organism that lives and stably harbors genetic information in its DNA, said Floyd Romesberg, a chemist at La Jolla, California-based Scripps Research Institute, whose laboratory created the new organism. Instead of two base pairs, it has a third.

All life on earth is based on the combination of four chemicals. Adenine bonds naturally with thymine to create the A-T section of the formula, while guanine and cytosine make up the C-G part. The joining of these base pairs in different combinations creates amino acids and proteins that power life.

Romesbergs work differs from other research in the field of genetic engineering in that it involves creation of components that are purely synthetic and integrated into the machinery of life in a cell, he said in a telephone interview.

Other scientists in the field, notably J. Craig Venter, work by constructing genetic material from natural building blocks, or natural components of DNA and proteins.

Starting in 2009, Romesberg and his laboratory created about 300 nucleotides with the newly constituted DNA before landing on ones they believed might be able to replicate in a cell. They then used a special chemical transporter to get the synthetic base pair into an E.coli cell, where it replicated without affecting cell growth. That suggests it wasnt recognized as atypical by the bodys natural DNA repair machinery, according to the paper.

Synthorx Inc., a San Diego-based biotechnology company, has exclusive rights to the synthetic biology from Scripps. The company plans to focus on developing the technology for use in vaccines, medicines and diagnostics, the company said yesterday in a statement.

The research, though promising for fields of medicine and drug development, will probably raise ethical and safety concerns, said Arthur Caplan, head of the division of bioethics at NYU Langone Medical School. He called the research promising.

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Scientists Add New Letters to Lifes Genetic Alphabet

For possibly billions of years, the DNA blueprints for life on Earth have been written with just four genetic "letters" -- A, T, G and C. On Wednesday, scientists announced that that they added two more.

In a paper published in the journal Nature, bio-engineers at Scripps Research Institute in La Jolla said they had successfully inserted two synthetic molecules into the genome of an Escherichia coli bacterium, which survived and passed on the new genetic material.

In addition to the naturally occurring nucleotides adenine, thymine, guanine and cytosine, which form the rungs of DNA's double-helix structure, the bacterium carried two more base-pair partners, which study authors have dubbed d5SICS and dNaM.

For more than a decade, scientists have been experimenting with so-called unnatural base pairs, or UBPs, saying they may hold the key to new antibiotics, future cancer drugs, improved vaccines, nanomaterials and other innovations.

Until now, however, those experiments have all been conducted in test tubes.

"These unnatural base pairs have worked beautifully in vitro, but the big challenge has been to get them working in the much more complex environment of a living cell," lead study author Denis Malyshev, a molecular and chemical biologist at Scripps, said in a prepared statement.

The new genetic material did not appear to be toxic to the bacteria, and it only remains in the organism's genome under specific lab conditions. In a natural environment, the molecules -- nucleoside triphosphates -- degrade and disappear in a day or two. Once they disappear, the bacterium reverts back to its natural base pair arrangement.

Still, experts said insertion of the synthetic materials into E. coli's genome was a milestone.

"This definitely is a significant achievement," said Ross Thyer, a synthetic biologist at the University of Texas at Austin, who was not involved in the research. "What I'm most excited about is how this will help us answer some bigger evolutionary questions: Why has life settled on a specific set of bases."

Malyshev and colleagues went about creating the semi-synthetic bacterium by genetically engineering a stretch of ring-like DNA known as a plasmid.

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Scientists add new letters to bacteria's genetic 'alphabet'

Vermont Governor Pat Shumlin intends to sign legislation requiring the labeling of foods that contain ingredients that are genetically modified (GMOs) or produced with genetic engineering. The governors office announced via Twitter that the signing will take place Thursday, May 8. Once the bill is signed, Vermont will become the first state to require mandatory GMO labeling.

The Vermont House approved the bill as amended by the Senate by a vote of 114-30 on April 24. The proposed effective date is July 1, 2016.

It is estimated that 80% of all food sold in the United States is at least partially produced from genetic engineering. The bill would require labeling on all such food sold at retail in Vermont, regardless of whether the food was manufactured in the state. Vermont lawmakers included a $1.5 million legal defense fund in the bill because they expect the law to face legal challenges after the signing.

While the bill exempts processing aids and milk from cows that have been fed GMO feed, many dairy products and other foods that incorporate milk would be affected unless they were made with organic ingredients.

New York GMO bill advances

The New York General Assemblys Committee on Consumer Affairs and Protection advanced a bill on Tuesday that would require the labeling of GMOs. The committee voted 9-6 to approve AB 3525 and now will send the bill to the Committee on Codes. The bill is similar to Vermonts legislation as it would take effect without needing the surrounding states to pass labeling bills.

The New York legislation contains the same exemptions for processing aids and milk from cows that have been fed GMO feed or treated with GMO material. The bill must be approved by both the Assembly and the state Senate before the June 19 recess date and signed by the governor before it can become law.

The Food and Drug Administration, American Medical Association, World Health Organization, USDA and the National Academy of Sciences all have said that GMO ingredients are safe and there are no negative health effects associated with their use.

The International Dairy Foods Association (IDFA) and many other trade organizations oppose individual state legislation on GMO labeling and fully supportThe Safe and Accurate Food Labeling Act of 2014introduced last month by Reps. Mike Pompeo (R-KS) and G.K. Butterfield (D-NC). This bill would preempt states from requiring mandatory labeling and establish a federal standard for voluntary labeling of food and beverage products made with GMOs.

IDFA is working with the Safe and Affordable Food Coalition, headed by the Grocery Manufacturers Association, on issues related to GMO labeling.

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Vermont governor to sign GMO labeling bill

The first report of a bacterium whose genome contains man-made DNA building blocks opens the door for tailor-made organisms that could be used to produce new drugs and other products.

All living creatures have a DNA "alphabet" of just four letters, which encode instructions for the proteins that perform most of the key jobs inside cells. But expanding that alphabet to include artificial letters could give organisms the ability to produce new proteins never seen before in nature.

The man-made DNA could be used for everything from the manufacture of new drugs and vaccines to forensics,researchers say.

"What we have done is successfully store increased information in the DNA of a living cell," study leader Floyd Romesberg, a chemical biologist at The Scripps Research Institute in La Jolla, Calif., told Live Science. Yet many steps remain before Romesberg and his colleagues can get cells to produce artificial proteins. [Biomimicry: 7 Clever Technologies Inspired by Nature]

DNA alphabet

The field of synthetic biology involves tinkering with DNA to create organisms capable of novel functions in medicine, energy and other areas.

The DNA alphabet consists of four letters, or bases: adenine, thymine, guanine and cytosine (A, T, G and C). Adenine pairs with thymine, and guanine pairs with cytosine. RNA is a genetic material similar to DNA, except it has a different chemical backbone and replaces the base thymine with uracil (U).

Living things translate DNA into proteins through a series of steps. First, enzymes "transcribe" the DNA into RNA. Then, structures called ribosomes translate the DNA into proteins, which are made up of strands of molecules called amino acids.

Ultimately, the researchers aim to create organisms that can produce artificial proteins. But first, they need to show that the DNA containing the man-made letters can be transcribed into RNA, and that this RNA can be translated into proteins.

In the study, Romesberg and his team created an new pair of DNA letters not found in nature and inserted the pair into cells of Escherichia coli bacteria. Getting the DNA into the cells is not easy, but the researchers were able to do it by way of a transporter, a protein that moves materials across cell membranes.

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Weird Engineered Organism Has 6-Letter DNA

In an undated handout photo, Floyd Romesberg, a chemistry professor at the Scripps Research Institute and leader of a team that has created an organism with a partially artificial genetic code. The research, published on May 7, 2014, is likely to raise safety concerns and ethical questions, but scientists also say it could lead to medicines and industrial products that could not be made otherwise. (Scripps Research Institute via The New York Times)

The accomplishment might eventually lead to organisms that can make medicines or industrial products that cells with only the natural genetic code cannot. The scientists behind the work at the Scripps Research Institute have already formed a company to try to use the technique to develop new antibiotics, vaccines and other products, though a lot more work needs to be done before this is practical.

The work also gives some support to the concept that life can exist elsewhere in the universe using genetics different from those on Earth.

"This is the first time that you have had a living cell manage an alien genetic alphabet," said Steven A. Benner, a researcher in the field at the Foundation for Applied Molecular Evolution in Gainesville, Fla., who was not involved in the new work.

But the research, published online by the journal Nature, is bound to raise safety concerns and questions about whether humans are playing God. The new paper could intensify calls for greater regulation of the budding field known as synthetic biology, which involves the creation of biological systems intended for specific purposes.

"The arrival of this unprecedented 'alien' life form could in time have far-reaching ethical, legal and regulatory implications," Jim Thomas of the ETC Group, a Canadian advocacy organization, said in an email. "While synthetic biologists invent new ways to monkey with the fundamentals of life, governments haven't even been able to cobble together the basics of oversight, assessment or regulation for this surging field."

Despite the great diversity of life on Earth, all species, from simple bacteria to human beings, use the same genetic code. It consists of four chemical units in DNA, sometimes called nucleotides or bases, that are usually represented by the letters A, C, G and T. The sequence of these chemical units determines what proteins the cell makes. Those proteins in turn do most of the work in cells and are required for the structure, function and regulation of the body's tissues and organs.

The Scripps researchers chemically created two new nucleotides, which they called X and Y. They inserted an X-Y pair into the common bacterium E. coli. The bacteria were able to reproduce normally, though a bit more slowly than usual, replicating the X and Y along with the natural nucleotides.

In effect, the bacteria have a genetic code of six letters rather than four, perhaps allowing them to make novel proteins that could function in a completely different way from those created naturally.

"If you have a language that has a certain number of letters, you want to add letters so you can write more words and tell more stories," said Floyd E. Romesberg, a chemist at Scripps who led the work.

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Scientists Add Letters to DNA's Alphabet, Raising Hope and Fear

FOJC RADIO - DAVID CARRICO - GENETICS OF SALVATION MARK OF THE BEAST - FOLLOWERS OF JESUS CHRIST
THE GENETICS OF SALVATION THE MARK OF THE BEAST FOJC RADIO DAVID CARRICO FOLLOWERS OF JESUS CHRIST RADIO FOJC RADIO - DAVID CARRICO WEBSITE - http://www.fo...

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Jurassic Genetics | Second Tech Demo (With Added Stegosaurus!)
Dinosaaaaauuuurs! No drama, please. Ta. Much love. Subscribe with this handy dandy link! http://bit.ly/13OT2RF Jurassic Genetics on Facebook https://www.facebook.com/JurasscGenetics...

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Physiotherapie Spinal Cord Injury
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Scotiabank Half Marathon 5km Charity Challenge: Spinal Cord Injury
Michel McDermott talks to Kirsten Sharp, Spinal Cord Injury BC "Walk #39;n Roller" team captain about the importance of the Scotiabank Charity Challenge how i...

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Scotiabank Half Marathon & 5km Charity Challenge: Spinal Cord Injury - Video

A study has found that it is possible to convert skin cells into the male germ cells, which are responsible for sperm production in the testes, using an established technique for creating embryonic stem cells using a form of genetic engineering.

The researchers showed that stem cells derived from human skin become active germ cells when transplanted into the testes of mice even when the man suffers from a genetic condition where he lacks functioning germ cells in his own testes.

Creating sperm-producing human cells in laboratory mice will allow scientists to study in more detail the complex sequence of events during the development if the male reproductive tissue, and to understand how these developmental changes can go awry in infertile men.

Our results are the first to offer an experimental model to study sperm development. Therefore, there is potential for applications [such as] cell-based therapies in the clinic, for example, for the generation of higher quality and numbers of sperm in a dish, said Renee Reijo Pera of Montana State University.

It might even be possible to transplant stem cell-derived germ cells directly into the testes of men with problems producing sperm, said Professor Reijo Pera, who led the study published in the journal Cell Reports. However, she emphasised that further research will be needed before clinical trials can be allowed on humans.

Although the mice had functioning human male germ cells, they did not produce human sperm, Dr Reijo Pera said. There is an evolutionary block that means that when germ cells from one species are transferred to another, there is not full spermatogenesis, unless the species are very closely related, she explained.

About one in a hundred men suffer from azoospermia, where they fail to produce measurable quantities of sperm in the semen. The condition is responsible for about 20 per cent of cases of male infertility, which itself accounts for about half of the 10-15 per cent of couples who have difficulty conceiving naturally.

The study involved creating induced pluripotent stem cells by adding key genes to the skin cells of five men three with a form of azoospermia caused by a genetic mutation on the Y chromosome and two with normal fertility. The resulting stem cells were implanted into the testes of laboratory mice where they developed normally into germ cells.

The scientists found that even the stem cells derived from the infertile men were capable to developing into human male germ cells in the mouse testes. However, the stem cells of the men with the Y chromosome mutation produced about 100 times less germ cells than the men with normal fertility, Professor Reijo Pera said.

Studying why this is the case will help us to understand where the problems are for these men and hopefully find ways to overcome them, Professor Reijo Pera said.

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New infertility treatment could grow sperm from skin cells

Simple Mendelian genetics problem and solution
Huntington #39;s disease is an inherited disease that causes the progressive breakdown (degeneration) of nerve cells in the brain. Huntington #39;s disease has a bro...

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Genetics - Live in Chile (4 de Mayo 2014)
Dancing With The Moonlit Knight Teatro Caupolican Grab: Miguel Sanchez C.

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Are Genetics A Determining Factor In How Fast You Age?
One of the biggest misconceptions about aging is that how fast and how well you age are largely determined by genetics. While what your parents gave you will affect tissue degeneration throughout...

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Treating Knee Osteoarthritis with Stem Cells - Dr. Ben Newton | Regenexx
Dr. Ben Newton discusses knee osteoarthritis and the use of stem cells for treating this common condition and avoiding knee replacement surgery. Regenexx off...

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13 hours ago Cells with activated Wnt can no longer be reprogrammed (in green) are located on the periphery; cells that can be reprogrammed are aggregated anad can be seen in the center of the image (in red) Credit: CRG

In 2012, John B. Gurdon and Shinya Yamakana were awarded the Nobel Prize in medicine for discovering that adult cells can be reprogrammed into pluripotent ones (iPS); the cells obtained are capable of behaving in a similar way to embryonic stem cells, and hence have enormous potential for regenerative medicine.

However, although there are many research groups around the world studying this process, it is still not completely understood, it is not totally efficient, and it is not safe enough to be used as the basis for a new cell therapy.

Now, researchers at the Centre for Genomic Regulation (CRG) in Barcelona have taken a very important step towards understanding cell reprogramming and its efficiency: they have discovered the key role of the Wnt signalling pathway in transforming adult cells into iPS cells.

"Generally, transcription factors are used to try to increase or decrease the cell reprogramming process. We have discovered that we can increase the efficiency of the process by inhibiting the Wnt route", explains Francesco Aulicino, a PhD student in the Reprogramming and Regeneration group, led by Maria Pia Cosma and co-author of the study that has just been published in Stem Cell Reports.

The Wnt signaling pathway is a series of biochemical reactions that are produced in cells. In frogs or lizards, for example, these reactions are those that allow their extremities to regenerate if the animal suffers an injury. Although in general, humans and mammals have lost this regenerative capacity, the Wnt pathway is involved in numerous processes during embryonic development and cell fusion.

As it is in reprogramming. The researchers have studied how the Wnt route behaves throughout the entire process of transforming cells into iPS cells, which usually lasts two weeks. It is a very dynamic process that produces oscillations from the pathway, which is not active all the time. "We have seen that there are two phases and that in each one of them, Wnt fulfils a different function. And we have shown that by inhibiting it at the beginning of the process and activating it at the end we can increase the efficiency of reprogramming and obtain a larger number of pluripotent cells", indicates Ilda Theka, also a PhD student in Pia Cosma's group and a co-author of the article.

To artificially control the pathway, the group has employed a chemical molecule, Iwp2, which is a Wnt secretion inhibitor that does not permanently alter the cells, something which other research into reprogramming using different factors has still has not been able to acheive.

They have also seen that the exact moment when the Wnt pathway is activated is crucial. Doing it too early, makes the the cells begin to differentiate, for example into neurones or endodermal cells, and they are not reprogrammed.

"It is a very important and an innovative advance in the field of cell reprogramming, because until now this was a very inefficient process. There are many groups trying to understand the mechanism by which adult cells become pluripotent, and what blocks that process and makes only a small percentage of cells end up being reprogrammed. We are providing information on why it happens", says Theka.

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One step closer to cell reprogramming

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6-May-2014

Contact: Sally Stewart sally.stewart@cshs.org 310-248-6566 Cedars-Sinai Medical Center

LOS ANGELES (EMBARGOED UNTIL NOON ET ON MAY 6, 2014) Investigators at the Cedars-Sinai Heart Institute whose previous research showed that cardiac stem cell therapy reduces scarring and regenerates healthy tissue after a heart attack in humans have identified components of those stem cells responsible for the beneficial effects.

In a series of laboratory and lab animal studies, Heart Institute researchers found that exosomes, tiny membrane-enclosed "bubbles" involved in cell-to-cell communication, convey messages that reduce cell death, promote growth of new heart muscle cells and encourage the development of healthy blood vessels.

"Exosomes were first described in the mid-1980s, but we only now are beginning to appreciate their potential as therapeutic agents. We have found that exosomes and the cargo they contain are crucial mediators of stem cell-based heart regeneration, and we believe this might lead to an even more refined therapy using the 'active ingredient' instead of the entire stem cell," said Eduardo Marbn, MD, PhD, director of the Cedars-Sinai Heart Institute and a pioneer in developing investigational cardiac stem cell treatments.

"The concept of exosome therapy is interesting because it could potentially shift our strategy from living-cell transplantation to the use of a non-living agent," he added. "Stem cells must be carefully preserved to keep them alive and functioning until the time of transplant, and there are some risks involved in cell transplantation. In contrast, exosome therapy may be safer and simpler and based on a product with a longer shelf life."

In lab experiments, the researchers isolated exosomes from specialized human cardiac stem cells and found that exosomes alone had the same beneficial effects as stem cells. Exosomes also produced the same post-heart attack benefits in mice, decreasing scar size, increasing healthy heart tissue and reducing levels of chemicals that lead to inflammation. Even when exosomes were injected in mice after heart attack scars were well-established, and traditionally viewed as "irreversible," they brought about multiple structural and functional benefits.

Exosomes transport small pieces of genetic material, called microRNAs, that enable cells to communicate with neighboring cells to change their behavior. The researchers pinpointed one such microRNA one that is especially plentiful in cardiac stem cell exosomes as responsible for some of the benefits. It is likely, they believe, that this and other microRNAs in the exosomes work together to produce the regenerative effects.

"The exosomes appear to contain the signaling information needed to regenerate healthy heart tissue, they are naturally able to permeate cells, and they have a coating that protects their payloads from degradation as they shuttle from cell to cell," said Marbn, senior author of an article in the May 6, 2014 Stem Cell Reports. "Injecting exosomes derived from specialized cardiac stem cells may be an attractive alternative to the transplantation of living cells."

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Cedars-Sinai researchers identify how heart stem cells orchestrate regeneration

Avoiding UTI #39;s After a Spinal Cord Injury
In this video I share tips and tricks to avoid urinary tract infections induced by intermittent catheter use.

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Team Filosoma - eFactor 2014
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May 05, 2014 This is a microscopic view of the engineered bone with an opening exposing the internal trabecular bony network, overlaid with colored images of blood cells and a supportive vascular network that fill the open spaces in the bone marrow-on-a-chip. Credit: Harvard's Wyss Institute

The latest organ-on-a-chip from Harvard's Wyss Institute for Biologically Inspired Engineering reproduces the structure, functions and cellular make-up of bone marrow, a complex tissue that until now could only be studied intact in living animals, Institute researchers report in the May 4, 2014, online issue of Nature Methods. The device, dubbed "bone marrow-on-a-chip," gives scientists a much-needed new tool to test the effects of new drugs and toxic agents on whole bone marrow.

Specifically, the device could be used to develop safe and effective strategies to prevent or treat radiation's lethal effects on bone marrow without resorting to animal testing, a challenge being pursued at the Institute with funding from the U.S. Food and Drug Administration (FDA). In an initial test, the engineered bone marrow, like human marrow, withered in response to radiation unless a drug known to prevent radiation poisoning was present.

The bone marrow-on-a-chip could also be used in the future to maintain a cancer patient's own marrow temporarily while he or she underwent marrow-damaging treatments such as radiation therapy or high-dose chemotherapy.

"Bone marrow is an incredibly complex organ that is responsible for producing all of the blood cell types in our body, and our bone marrow chips are able to recapitulate this complexity in its entirety and maintain it in a functional form in vitro," said Don Ingber, M.D., Ph.D., Founding Director of the Wyss Institute, Judah Folkman Professor of Vascular Biology at Harvard Medical School and Boston Children's Hospital, Professor of Bioengineering at the Harvard School of Engineering and Applied Sciences, and senior author of the paper.

Ingber leads a large effort to develop human organs-on-chipssmall microfluidic devices that mimic the physiology of living organs. So far Wyss Institute teams have built lung, heart, kidney, and gut chips that reproduce key aspects of organ function, and they have more organs-on-chips in the works. The technology has been recognized internationally for its potential to replace animal testing of new drugs and environmental toxins, and as a new way for scientists to model human disease.

To build organ chips, in the past Wyss teams have combined multiple types of cells from an organ on a plastic microfluidic device, while steadily supplying nutrients, removing waste, and applying mechanical forces the tissues would face in the body. But bone marrow is so complex that they needed a new approach to mimic organ function.

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This complexity arises because bone marrow has an integral relationship with bone. Marrow sits inside trabecular bonea solid-looking type of bone with a porous, honeycombed interior. Throughout the honeycomb, conditions vary. Some areas are warmer, some cooler; some are oxygen-rich, others oxygen-starved, and the dozen or so cell types each have their own preferred spots. To add complexity, bone marrow cells communicate with each other by secreting and sensing a variety of biomolecules, which act locally to tell them whether to live, die, specialize or multiply.

Rather than trying to reproduce such a complex structure cell by cell, the researchers enlisted mice to do it.

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Bone marrow-on-a-chip unveiled

JACKSONVILLE, Fla. -

Hemorrhagic stroke is responsible for more than 30 percent of all stroke deaths. It happens when a weakened blood vessel ruptures and bleeds into the brain.

Its something Jon Galvan experienced five years ago when he almost died from a hemorrhagic stroke while at work.

"I was typing away and I felt a pop in my head," Galvan said.

He was able to recover, but Dr. Abba Zubair, medical director of transfusion medicine and stem cell therapy at Mayo Clinic, Florida, said not everyone is as fortunate.

"If it happens, you either recover completely or die," Zubair said. "Thats what killed my mother."

Zubair said he wants to send bone marrow derived stem cells to the international space station.

"Based on our experience with bone marrow transplant, you need about 200 to 500 million cells," Zubair said.

But conventionally grown stem cells take a month. Experiments on earth have shown that stem cells will grow faster in less gravity.

"Five to ten times faster, but it could be more," Zubair said.

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Health Beat: Growing stem cells in space: Medicine's next big thing?

FAITH Stem Cell Research and Human Cloning by: FR. GAMMY TULABING I would like to share with you this article from the United States Conference of Catholic Bishops.

Questions and Answers

What is a stem cell?

A stem cell is a relatively unspecia-lized cell that, when it divides, can do two things: make another cell like itself, or make any of a number of cells with more specialized functions. For example, just one kind of stem cell in our blood can make new red blood cells, or white blood cells, or other kindsdepending on what the body needs. These cells are like the stem of a plant that spreads out in different directions as it grows.

Is the Catholic Church opposed to all stem cell research?

Not at all. Most stem cell research uses cells obtained from adult tissue, umbilical cord blood, and other sources that pose no moral problem. Useful stem cells have been found in bone marrow, blood, muscle, fat, nerves, and even in the pulp of baby teeth. Some of these cells are already being used to treat people with a wide variety of diseases.

Why is the Church opposed to stem cell research using the embryo?

Because harvesting these stem cells kills the living human embryo. The church opposes the direct destruction of innocent human life for any purpose, including research.

If some human embryos will remain in frozen storage and ultimately be discarded anyway, why is it wrong to try to get some good out of them?

In the end, we will all die anyway, but that gives no one a right to kill us. In any case, these embryos will not die because they are inherently unable to survive, but because others are choosing to hand them over for destructive research instead of letting them implant in their mothers womb. One wrong choice does not justify an additional wrong choice to kill them for research, much less a choice to make tax payers support such destruction. The idea of experimenting on human beings because they may die anyway also poses a grave threat to convicted prisoners, terminally ill patients, and others.

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Questions and Answers