Archive for March, 2015

Home Books Author Jeanne Ryan discusses Charisma and gene therapy

Author Jeanne Ryan talks with Hypable about her book Charisma and whether or not she would take her fictional drug if given the chance.

Charisma follows the story of Aislyn, a painfully shy junior in high school who suffers from social anxiety. Speaking up in class and trying to have fun with her friends at a party are well outside her comfort zone. She finds out about a new underground gene therapy treatment in the form of a drug called Charisma. Aislyns personality completely changes, and suddenly shes exactly the person she wanted to be all along.

But theres one problem. The therapy appears to be contagious and deadly. Worse yet, the doctor who gave her and a select number of other patients the drug suddenly disappears. Read our review.

Tell us 5 random facts about yourself.

Two of my brothers have the same name, kind of by accident. Just after my mom gave birth to her sixth kid in less than seven years, the nurse asked the name of her baby. Thinking the nurse meant the baby at home, my sleep-deprived mom gave her his name, and it ended up on the birth certificate.

I could swear that when I was a kid a certain soup company ran a commercial where the main lyric in its jingle was Constipation got you down? However, to this day, I have never been able to find anyone else who remembers this.

Until more recently than I care to admit, I thought narwhals were fictional. (In my defense, they look totally fake in photos!)

Id love to go to Burning Man one day.

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Author Jeanne Ryan discusses Charisma and gene therapy

Center of Innovation in Personalized Medicine (CIPM)
Center of Innovation in Personalized Medicine at King Abdulaziz University Website: http://cipm.kau.edu.sa/Default.aspx?Site_ID=714 lng=EN Email: cipm.info@k...

By: CIPM KAU

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Center of Innovation in Personalized Medicine (CIPM) - Video

Spinal Cord Injury Recovery at NeuroFit360, Walking On TD
NeuroFit360 is a physical therapy gym for individuals with neurological injuries located in Pembroke Pines, Florida. Located new the border of Miami and 30 m...

By: Guy Romain

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Spinal Cord Injury Recovery at NeuroFit360, Walking On TD - Video

Spinal Cord Injury Spotlight - Nick D. at Project Walk Houston
Nick Dalheim suffered at C4/5/6 spinal cord injury in February 2014 during a snowboarding accident. Nick uses a joystick chair to get around. He has been gai...

By: Project Walk

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Spinal Cord Injury Spotlight - Nick D. at Project Walk Houston - Video

Wnt pathway drives tumour growth in bile duct cancer
Prof Stuart Forbes said: "Experimental drugs blocking the wnt pathway might be beneficial for patients with bile duct cancer." The findings of the study, pub...

By: MRC Centre for Regenerative Medicine

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Wnt pathway drives tumour growth in bile duct cancer - Video

Stem Cell Sound Bites: Duchenne Muscular Dystrophy
Visit: http://www.uctv.tv/) Carrie Miceli and Stanley Nelson of UCLA describe their efforts to use stem cell-based strategies to find a drug treatment for d...

By: University of California Television (UCTV)

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Stem Cell Sound Bites: Duchenne Muscular Dystrophy - Video

Shoulder Labral Tear Repair Using Stem Cell Therapy - Orthopedic Surgeon, Dr. Wade McKenna
Board Certified Orthopedic Surgeon, Dr. Wade McKenna explains how Stemnexa stem cell therapy and amniotic tissue product can enhance the healing process for labral tears in the shoulder. For...

By: Riordan-McKenna Institute

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Shoulder Labral Tear Repair Using Stem Cell Therapy - Orthopedic Surgeon, Dr. Wade McKenna - Video

What Makes Riordan-McKenna Institute Different? Stem Cell Therapy for Orthopedics
Dr. McKenna explains how RMI is a unique combination of a world-renowned stem cell scientist (Neil Riordan, PhD) and an experienced orthopedic surgeon to bring patients the best of both worlds...

By: Riordan-McKenna Institute

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What Makes Riordan-McKenna Institute Different? Stem Cell Therapy for Orthopedics - Video

Overcoming Knee Replacement Surgery Faster Using Amniotic Tissue-Enhanced Stem Cell Therapy
Dr. McKenna discusses how the addition of a patient #39;s own bone marrow stem cells combined with AlphaGEMS amniotic tissue product helps patients recover faster from a total knee replacement ...

By: Riordan-McKenna Institute

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Overcoming Knee Replacement Surgery Faster Using Amniotic Tissue-Enhanced Stem Cell Therapy - Video

stem cell therapy helps avoiding knee surgery
Meet John Tucker, he suffered from Osteoarthritis in his knee. Watch our live video to hear John #39;s experience with Stem Cells! RMG is also proud to announce we are offering at 100% Knee Guarantee!

By: iManifestart

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stem cell therapy helps avoiding knee surgery - Video

Stem Cell Therapy in Osteo Arthritis Knee
stem cell india, stem cell therapy india, stem cell in india, stem cell therapy in india, india stem cell, india stem cell therapy, Osteo Arthritis Knee.

By: Stem Cell India

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Stem Cell Therapy in Osteo Arthritis Knee - Video

Stem cell therapy in AKI Dr Mohamed Kamal
Stem cell therapy in AKI Dr Mohamed Kamal.

By: HusseinSheashaa

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Stem cell therapy in AKI Dr Mohamed Kamal - Video

How do Stemnexa Stem Cell Procedures Heal Orthopedic Damage? - Dr. Wade McKenna, Orthopedic Surgeon
Board-Certified Orthopedic Surgeon, Dr. McKenna explains how Stemnexa bone marrow stem cells augmented with AlphaGEMS amniotic tissue product works in the hu...

By: Riordan-McKenna Institute

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How do Stemnexa Stem Cell Procedures Heal Orthopedic Damage? - Dr. Wade McKenna, Orthopedic Surgeon - Video

CHICAGO (CBS) More than four years after she was close to dying from leukemia, an 8-year-old girl from Mount Prospect is healthy again, and will meet the German man who helped save her life by supplying a stem cell donation.

Sabrina Chahir was diagnosed with leukemia in 2009, and 80 percent of her blood was filled with cancer cells. To survive, she needed a stem cell/bone marrow transplant, but finding a donor was going to be very difficult.

At the beginning, it was we didnt know if we were able to find one, because Sabrina is half Arabic and half Hispanic, and that is not a usual combination, Sabrinas mother, Natalia Wehr said.

Sabrinas DNA match turned out to be 30-year-old Maximilian Eule, a German supermarket manager living in Austria. He quickly agreed to donate

For me, I was close to crying, because it was like a little girl who was almost close to dying, and has no chance without my blood, he said. You give the girl another chance to stay alive.

Sabrinas mother said, thanks to Eules bone marrow donation, her daughter is healthy again, and like any other 2nd grade girl.

This whole thing is like a dream, she said.

Eule said its awesome Sabrina is now happy, healthy, and taking ballet classes and piano lessons. The two will meet for the first time Thursday night.

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Girl With Leukemia To Meet Stem Cell Donor Who Helped Save Her Life

Phytoscience Double Stemcell - Naturally Reverse Your Biological Clock
PhytoScience Double Stem Cell powder, a delicious proprietary blend of the signature stem cell extracts: - PhytoCellTec Malus Domestica (Apple Stem Cells) -...

By: NetBiz GlobalMarketing

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Phytoscience Double Stemcell - Naturally Reverse Your Biological Clock - Video

How PhytoCellTec Solar Vitis Works - Skin UV protection Stem Cell
Solar Vitis is based on stem cells from the GamayTeinturierFraux grape - a grape of Burgundy, which is characterized by an extremely high content of polyphe...

By: NetBiz GlobalMarketing

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How PhytoCellTec Solar Vitis Works - Skin UV protection Stem Cell - Video

A Stem Cell-Based Therapy for Retinitis Pigmentosa
Visit: http://www.uctv.tv/) Retinitis pigmentosa (RP) is a genetic disease that gradually destroys the light sensing nerve cells, called photoreceptors, loc...

By: University of California Television (UCTV)

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A Stem Cell-Based Therapy for Retinitis Pigmentosa - Video

Orthopedic Stem Cell Therapy From Bone Marrow
Stem Cell therapy derived from bone marrow is the latest in modern orthopedic medicine to help you alleviate severe joint pain, and avoid invasive joint repl...

By: Cross Bay Physical Medicine and Rehabilitation, P.C.

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Orthopedic Stem Cell Therapy From Bone Marrow - Video

Using Stem Cell Therapy to Repair Damaged Tissue from Shoulder Impingement Syndrome
Board Certified Orthopedic Surgeon, Dr. Wade McKenna discusses how Stemnexa stem cell therapy and amniotic tissue product can aid in healing frayed shoulder tissue damage from shoulder ...

By: Riordan-McKenna Institute

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Using Stem Cell Therapy to Repair Damaged Tissue from Shoulder Impingement Syndrome - Video

Knee arthritis one year after stem cell therapy by Harry Adelson, N.D.
Frank describes his outcome one year after stem cell therapy for his arthritic knee by Harry Adelson, N.D. http://www.docereclinics.com.

By: Harry Adelson, N.D.

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Knee arthritis one year after stem cell therapy by Harry Adelson, N.D. - Video

Florida panther receives Stem Cell Therapy
Florida Panther Gets Stem Cell Therapy at Newman Veterinary Centers in Florida.

By: dowsley9481

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Florida panther receives Stem Cell Therapy - Video

Stem Cell Therapy | Simple way to regrow cartilage
http://www.arthritistreatmentcenter.com Pioneering simple new technique to re-grow damaged cartilage Jo Willey writing in the UK Express reported researchers from the University of Texas Health...

By: Nathan Wei

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Stem Cell Therapy | Simple way to regrow cartilage - Video

This article was originally distributed via PRWeb. PRWeb, WorldNow and this Site make no warranties or representations in connection therewith.

We cordially invite everyone to attend a special open house event at the Riordan-McKenna Institute of Regenerative Orthopedics and Stem Cell Therapy (RMI) at 801 E. Southlake Blvd. in Southlake, Texas 76092 on Friday, March 6th from 5:30 pm to 7:30 pm. There will be plenty of food, drink and engaging conversation with world-renowned stem cell scientist, Neil H.Riordan, PhD and board-certified orthopedic surgeon, R. Wade McKenna, DO.

Southlake, Texas (PRWEB) March 05, 2015

RMI specializes in Stemnexa non-surgical treatment of acute and chronic orthopedic conditions such as meniscal tears, ACL injuries, rotator cuff injuries, runners knee, tennis elbow, and joint pain due to degenerative conditions like osteoarthritis. Stemnexa may also be administered during orthopedic surgeries to promote better post-surgical outcomes.

Stemnexa combines the latest, patented scientific advances in nearly pain-free bone marrow harvesting with two complimentary cellular technologies: Bone Marrow Aspirate Concentrate (BMAC) and *AlphaGEMS amniotic tissue product.

BMAC contains a patients own mesenchymal stem cells (MSC,) hematopoietic stem cells (CD34+), growth factors and other progenitor cells. AlphaGEMS is composed of collagens and other structural proteins, which provide a biologic matrix that supports angiogenesis, tissue growth and new collagen during tissue regeneration and repair.

*AlphaGEMS product is harvested from donated amniotic sac tissue after normal healthy births. For more information about AlphaGEMS, please visit: http://www.rmiclinic.com/non-surgical-stem-cell-injections-joint-pain/stemnexa-protocol/

Find out more about RMI in the February edition of Society Life Magazine.

Riordan-McKenna Institute

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Riordan-McKenna Institute of Regenerative Orthopedics and Stem Cell Therapy Announces Open House in Southlake, Texas ...

Sotos syndrome is a congenital syndrome that is characterized by varying degrees of mental retardation and a large head circumference etc. It is known that 90% of Sotos syndrome patients have mutations in the NSD1 gene. This time, an international research group has revealed that mutation in the APC2 gene causes symptoms of Sotos syndrome related to the nervous system, from analyses of the Apc2-knockout mouse. They also showed that the APC2 gene is a crucial downstream gene of the NSD1 gene. The results of this work will be published in the journal Cell Reports on the 5th of March 2015.

Research members in Qatar and Canada found that siblings (a sister and a brother), diagnosed with Sotos-like syndrome, have a mutation in the APC2 gene. Research members in Japan, Prof. Masaharu Noda and Assoc. Prof. Takafumi Shintani, at the National Institute for Basic Biology, National Institutes of Natural Sciences, showed that this mutation in the APC2 gene causes loss of the protein function.

The Japanese team has studied APC2 gene functions using mice for several years. They have already reported that APC2 controls the cytoskeletal dynamics, and that the migration of neurons was abnormal in the brain of the Apc2-knockout mice. In the current study, they showed that the Apc2-knockout mouse exhibited significantly impaired learning and memory abilities, together with an abnormal brain structure as well as head shape. All these phenotypes are similar to symptoms of Sotos syndrome. The research group also showed that APC2 is one of the downstream genes of the NSD1 gene, using primarily cultured neurons and developing mouse embryos.

Prof. Noda said, "The downstream mechanisms of NSD1, the responsible gene for Sotos syndrome, had been unclear for a long time. And there was no suitable model animal for Sotos syndrome research. The Apc2-knockout mouse appears to be a good model for future investigation of Sotos syndrome."

Story Source:

The above story is based on materials provided by National Institutes of Natural Sciences. Note: Materials may be edited for content and length.

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Mutation in APC2 gene causes Sotos features

For the first time, CRISPR-Cas9 gene-editing technology has been employed in a whole organism model to systematically target every gene in the genome. A team of scientists at the Broad Institute and MIT's David H. Koch Institute for Integrative Cancer Research have pioneered the use of this technology to "knock out," or turn off, all genes across the genome systematically in an animal model of cancer, revealing genes involved in tumor evolution and metastasis and paving the way for similar studies in other cell types and diseases. The work appears online March 5 in Cell.

"Genome-scale guide RNA libraries are a powerful screening system, and we're excited to start applying it to study gene function in animal models," said co-senior author Feng Zhang, core member of the Broad Institute of MIT and Harvard, investigator at the McGovern Institute for Brain Research at MIT, and assistant professor in the MIT Departments of Brain and Cognitive Sciences and Biological Engineering. "This study represents a first step toward using Cas9 to identify important genes in cancer and other complex diseases in vivo."

"Tumor evolution is an extremely complex set of processes, or hallmarks, controlled by networks of genes," said co-senior author Phillip Sharp, Institute Professor at the Massachusetts Institute of Technology, board member at the Broad Institute, and member of the Koch Institute. "The in vivo application of gene-editing is a powerful platform for functional genomic discovery, offering a novel means to investigate each step in tumor evolution and identify the genes that regulate these hallmarks."

CRISPR-Cas9 gene-editing technology enables scientists to investigate the role of genes and genetic mutations in human biology and disease. The system can remove the function of genes at the DNA level, versus other genetic perturbations like RNA interference that "knock down" genes at the RNA level. Broad Institute scientists previously performed genome-wide screens using CRISPR-Cas9 technology in cellular models, but that approach does not capture the complex processes at play in a whole organism. For example, for cancer to metastasize, malignant cells must leave the primary tumor, enter blood vessels to travel to a distant site in the body, leave the blood vessels, and thrive in a new environment. Zhang and Sharp teamed up to search for genes involved in metastasis by applying CRISPR-Cas9 technology in a whole animal model.

In the new study, cells from a mouse model of non-small cell lung cancer (NSCLC) were treated with the Broad's pooled library of CRISPR guide RNAs targeting every gene in the mouse genome, known as the "mouse genome-scale CRISPR knockout library A" (mGeCKOa), along with the Cas9 DNA-cutting enzyme. The system introduces mutations into specific genes, disrupting their sequence and preventing the production of proteins from those genes. The approach ensured that in each cell, only a single gene was knocked out, and that all genes in the mouse genome were targeted by the heterogeneous population of cells in culture. The researchers then transplanted the cells into a mouse and found that cells treated with the knockout library formed highly metastatic tumors.

Using next-generation sequencing, the scientists were able to identify which genes were knocked out in the primary tumors and in the metastases, indicating that the genes are likely tumor suppressors that normally inhibit tumor growth but, when knocked out, promote it.

The results highlighted some well-known tumor suppressor genes in human cancer, including Pten, Cdkn2a, and Nf2, but included some genes not previously linked to cancer. Unexpectedly, the screen also implicated several microRNAs -- small RNA segments that are functional in the cell.

More experimental work remains to fully explore the genes and microRNAs uncovered in the screen. Metastatic tumors are rarely biopsied in the clinic, making samples for research scarce, but future inclusion of metastases in cancer sequencing studies will yield more insight on hits from this study.

Researchers can take the same in vivo approach described in the Cell paper to examine the effects of gene over-expression, to screen circulating tumor cells or other cell lines, and to explore other cancer phenotypes, such as cancer stem cells, host-environment interactions, and angiogenesis.

"Our work provides a proof-of-principle in vivo knockout screen for identification of genes regulating different routes and steps of tumor evolution," said Sidi Chen, co-first author and a postdoctoral fellow working in the Sharp lab.

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In vivo CRISPR-Cas9 screen sheds light on cancer metastasis, tumor evolution