Hemostasis and complement in allogeneic hematopoietic stem cell transplantation: clinical significance of two interactive systems – Nature.com
Posted: July 19, 2024 at 2:50 am
Copelan EA, Chojecki A, Lazarus HM, Avalos BR. Allogeneic hematopoietic cell transplantation; the current renaissance. Blood Rev. 2019;34:3444.
Article CAS PubMed Google Scholar
Modi D, Uberti J. Hematopoietic stem cell transplantation: an overview. In: Pulmonary and Critical Care Considerations of Hematopoietic Stem Cell Transplantation. Springer International Publishing: Cham, 2023,115.
Gratwohl A, Pasquini MC, Aljurf M, Atsuta Y, Baldomero H, Foeken L, et al. One million haemopoietic stem-cell transplants: a retrospective observational study. Lancet Haematol. 2015;2:e91e100.
Article PubMed Google Scholar
Wong E, Davis JE, Grigg A, Szer J, Ritchie D. Strategies to enhance the graft versus tumour effect after allogeneic haematopoietic stem cell transplantation. Bone Marrow Transpl. 2019;54:17589.
Article CAS Google Scholar
Conway EM. Reincarnation of ancient links between coagulation and complement. J Thromb Haemost. 2015;13:S121S132.
Article CAS PubMed Google Scholar
Ricklin D, Reis ES, Lambris JD. Complement in disease: a defence system turning offensive. Nat Rev Nephrol. 2016;12:383401.
Article CAS PubMed PubMed Central Google Scholar
Oikonomopoulou K, Ricklin D, Ward PA, Lambris JD. Interactions between coagulation and complement-their role in inflammation. Semin Immunopathol. 2012;34:15165.
Article CAS PubMed Google Scholar
Duval A, Frmeaux-Bacchi V. Complement biology for hematologists. Am J Hematol 2023;98. https://doi.org/10.1002/ajh.26855.
Schmidt CQ, Schrezenmeier H, Kavanagh D. Complement and the prothrombotic state. Blood. 2022;139:195472.
Article CAS PubMed Google Scholar
Milone G, Bellofiore C, Leotta S, Milone GA, Cupri A, Duminuco A, et al. Endothelial dysfunction after hematopoietic stem cell transplantation: a review based on physiopathology. J Clin Med. 2022;11:623.
Article CAS PubMed PubMed Central Google Scholar
Moreno-Castao AB, Salas MQ, Palomo M, Martinez-Sanchez J, Rovira M, Fernndez-Avils F et al. Early vascular endothelial complications after hematopoietic cell transplantation: Role of the endotheliopathy in biomarkers and target therapies development. Front Immunol 2022;13. https://doi.org/10.3389/fimmu.2022.1050994.
Stassen J, Arnout J, Deckmyn H. The hemostatic system. Curr Med Chem. 2004;11:224560.
Article CAS PubMed Google Scholar
Hoffman M, Monroe DM. A cell-based model of hemostasis. Thromb Haemost. 2001;85:95865.
Article CAS PubMed Google Scholar
Merle NS, Church SE, Fremeaux-Bacchi V, Roumenina LT. Complement system part I molecular mechanisms of activation and regulation. Front Immunol 2015; 6. https://doi.org/10.3389/fimmu.2015.00262.
Merle NS, Noe R, Halbwachs-Mecarelli L, Fremeaux-Bacchi V, Roumenina LT. Complement system part II: Role in immunity. Front Immunol 2015;6. https://doi.org/10.3389/fimmu.2015.00257.
Mastellos DC, Hajishengallis G, Lambris JD. A guide to complement biology, pathology and therapeutic opportunity. Nat Rev Immunol. 2024;24:11841.
Article CAS PubMed Google Scholar
Elvington M, Liszewski MK, Atkinson JP. Evolution of the complement system: from defense of the single cell to guardian of the intravascular space. Immunol Rev. 2016;274:915.
Article CAS PubMed PubMed Central Google Scholar
Noris M, Galbusera M. The complement alternative pathway and hemostasis. Immunol Rev. 2023;313:13961.
Article CAS PubMed Google Scholar
Donat C, Klm R, Csorba K, Tuncer E, Tsakiris DA, Trendelenburg M. Complement C1q enhances primary hemostasis. Front Immunol 2020;11. https://doi.org/10.3389/fimmu.2020.01522.
Amara U, Rittirsch D, Flierl M, Bruckner U, Klos A, Gebhard F, et al. Interaction between the coagulation and complement system. Adv Exp Med Biol. 2008;632:719.
CAS PubMed PubMed Central Google Scholar
del Conde I, Crz MA, Zhang H, Lpez JA, Afshar-Kharghan V. Platelet activation leads to activation and propagation of the complement system. J Exp Med. 2005;201:8719.
Article PubMed PubMed Central Google Scholar
Eriksson O, Mohlin C, Nilsson B, Ekdahl KN. The human platelet as an innate immune cell: interactions between activated platelets and the complement system. Front Immunol 2019;10. https://doi.org/10.3389/fimmu.2019.01590.
Arbesu I, Bucsaiova M, Fischer MB, Mannhalter C. Platelet-borne complement proteins and their role in plateletbacteria interactions. J Thromb Haemost. 2016;14:224152.
Article CAS PubMed PubMed Central Google Scholar
Puy C, Pang J, Reitsma SE, Lorentz CU, Tucker EI, Gailani D, et al. Cross-talk between the complement pathway and the contact activation system of coagulation: activated factor XI neutralizes complement factor H. J Immunol. 2021;206:178492.
Article CAS PubMed Google Scholar
Endo Y, Matsushita M, Fujita T. New insights into the role of ficolins in the lectin pathway of innate immunity. Int Rev Cell Mol Biol. 2015;316:49110.
Article CAS PubMed Google Scholar
de Bont CM, Boelens WC, Pruijn GJM. NETosis, complement, and coagulation: a triangular relationship. Cell Mol Immunol. 2019;16:1927.
Article PubMed Google Scholar
Zhu Y, Chen X, Liu X. NETosis and neutrophil extracellular Traps in COVID-19: immunothrombosis and beyond. Front Immunol. 2022;13. https://doi.org/10.3389/fimmu.2022.838011.
Lazana I. Transplant-associated thrombotic microangiopathy in the context of allogenic hematopoietic stem cell transplantation: where we stand. Int J Mol Sci. 2023;24:1159.
Article CAS PubMed PubMed Central Google Scholar
Meri S, Bunjes D, Cofiell R, Jodele S. The role of complement in HSCT-TMA: basic science to clinical practice. Adv Ther. 2022;39:3896915.
Article CAS PubMed PubMed Central Google Scholar
Gloude NJ, Khandelwal P, Luebbering N, Lounder DT, Jodele S, Alder MN, et al. Circulating dsDNA, endothelial injury, and complement activation in thrombotic microangiopathy and GVHD. Blood. 2017;130:125966.
Article CAS PubMed PubMed Central Google Scholar
Mohty M, Malard F, Alaskar AS, Aljurf M, Arat M, Bader P, et al. Diagnosis and severity criteria for sinusoidal obstruction syndrome/veno-occlusive disease in adult patients: a refined classification from the European Society for Blood and Marrow Transplantation (EBMT). Bone Marrow Transpl. 2023;58:74954.
Article Google Scholar
Mavrikou I, Chatzidimitriou D, Skoura L, Nikolousis E, Sakellari I, Gavriilaki E. Molecular advances in sinusoidal obstruction syndrome/veno-occlusive disease. Int J Mol Sci. 2023;24. https://doi.org/10.3390/ijms24065620.
Socie G, Michonneau D. Milestones in acute GVHD pathophysiology. Front Immunol 2022;13. https://doi.org/10.3389/fimmu.2022.1079708.
Zeiser R, Blazar BR. Pathophysiology of chronic graft-versus-host disease and therapeutic targets. N Engl J Med. 2017;377:256579.
Article CAS PubMed Google Scholar
Hill A, Kelly RJ, Hillmen P. Thrombosis in paroxysmal nocturnal hemoglobinuria. Blood. 2013;121:498596.
Article CAS PubMed Google Scholar
Oliver M, Patriquin C. Paroxysmal nocturnal hemoglobinuria: current management, unmet needs, and recommendations. J Blood Med. 2023;14:61328.
Article CAS PubMed PubMed Central Google Scholar
Yerigeri K, Kadatane S, Mongan K, Boyer O, Burke LL, Sethi SK, et al. Atypical hemolytic-uremic syndrome: genetic basis, clinical manifestations, and a multidisciplinary approach to management. J Multidiscip Health. 2023;ume 16:223349.
Article Google Scholar
Spasiano A, Palazzetti D, Dimartino L, Bruno F, Baccaro R, Pesce F, et al. Underlying genetics of aHUS: which connection with outcome and treatment discontinuation? Int J Mol Sci. 2023;24:14496.
Article CAS PubMed PubMed Central Google Scholar
Noris M, Remuzzi G. Glomerular diseases dependent on complement activation, including atypical hemolytic uremic syndrome, membranoproliferative glomerulonephritis, and C3 glomerulopathy: core curriculum 2015. Am J Kidney Dis. 2015;66:35975.
Article PubMed PubMed Central Google Scholar
Noris M, Remuzzi G. Genetics of immune-mediated glomerular diseases: focus on complement. Semin Nephrol. 2017;37:44763.
Article CAS PubMed Google Scholar
Delvasto-Nuez L, Jongerius I, Zeerleder S. It takes two to thrombosis: hemolysis and complement. Blood Rev. 2021;50:100834.
Article PubMed Google Scholar
Jger U, Barcellini W, Broome CM, Gertz MA, Hill A, Hill QA, et al. Diagnosis and treatment of autoimmune hemolytic anemia in adults: Recommendations from the First International Consensus Meeting. Blood Rev. 2020;41:100648.
Article PubMed Google Scholar
Knight JS, Kanthi Y. Mechanisms of immunothrombosis and vasculopathy in antiphospholipid syndrome. Semin Immunopathol. 2022;44:34762.
Article CAS PubMed PubMed Central Google Scholar
Tsakiris DA, Tichelli A. Thrombotic complications after haematopoietic stem cell transplantation: early and late effects. Best Pr Res Clin Haematol. 2009;22:13745.
Article Google Scholar
Pihusch R, Salat C, Schmidt E. Ghring P, Pihusch M, Hiller E, et al. Hemostatic complications in bone marrow transplantation: a retrospective analysis of 447 patients. Transplantation. 2002;74:13039.
Article PubMed Google Scholar
Nadir Y, Brenner B. Hemorrhagic and thrombotic complications in bone marrow transplant recipients. Thromb Res. 2007;120:S92S98.
Article PubMed Google Scholar
Eftychidis I, Sakellari I, Anagnostopoulos A, Gavriilaki E. Endothelial dysfunction and vascular complications after allogeneic hematopoietic cell transplantation: an expert analysis. Expert Rev Hematol. 2021;14:83140.
Article CAS PubMed Google Scholar
Jodele S, Laskin BL, Dandoy CE, Myers KC, El-Bietar J, Davies SM, et al. A new paradigm: diagnosis and management of HSCT-associated thrombotic microangiopathy as multi-system endothelial injury. Blood Rev. 2015;29:191204.
Article PubMed Google Scholar
Lia G, Giaccone L, Leone S, Bruno B. Biomarkers for early complications of endothelial origin after allogeneic hematopoietic stem cell transplantation: do they have a potential clinical role? Front Immunol. 2021;12. https://doi.org/10.3389/fimmu.2021.641427.
Chaturvedi S, Neff A, Nagler A, Savani U, Mohty M, Savani BN. Venous thromboembolism in hematopoietic stem cell transplant recipients. Bone Marrow Transpl. 2016;51:4738.
Article CAS Google Scholar
Labrador J, Lopez-Anglada L, Perez-Lopez E, Lozano FS, Lopez-Corral L, Sanchez-Guijo FM, et al. Analysis of incidence, risk factors and clinical outcome of thromboembolic and bleeding events in 431 allogeneic hematopoietic stem cell transplantation recipients. Haematologica. 2013;98:43743.
Article PubMed PubMed Central Google Scholar
Lee A, Badgley C, Lo M, Banez MT, Graff L, Damon L, et al. Evaluation of venous thromboembolism prophylaxis protocol in hematopoietic cell transplant patients. Bone Marrow Transpl. 2023;58:124753.
Article Google Scholar
Gerber DE, Segal JB, Levy MY, Kane J, Jones RJ, Streiff MB. The incidence of and risk factors for venous thromboembolism (VTE) and bleeding among 1514 patients undergoing hematopoietic stem cell transplantation: implications for VTE prevention. Blood. 2008;112:50410.
Article CAS PubMed Google Scholar
Gonsalves A, Carrier M, Wells PS, McDiarmid SA, Huebsch LB, Allan DS. Incidence of symptomatic venous thromboembolism following hematopoietic stem cell transplantation. J Thromb Haemost. 2008;6:146873.
Article CAS PubMed Google Scholar
Rotz SJ, Ryan TD, Hayek SS. Cardiovascular disease and its management in children and adults undergoing hematopoietic stem cell transplantation. J Thromb Thrombolysis. 2021;51:85469.
Article PubMed Google Scholar
Aghel N, Lui M, Wang V, Khalaf D, Mian H, Hillis C, et al. Cardiovascular events among recipients of hematopoietic stem cell transplantation-A systematic review and meta-analysis. Bone Marrow Transpl. 2023;58:47890.
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