Novoheart to Co-develop First of its Kind Human Heart-in-a-Jar Model of Heart Failure with AstraZeneca – GlobeNewswire
Posted: December 2, 2019 at 8:46 pm
VANCOUVER, British Columbia, Nov. 26, 2019 (GLOBE NEWSWIRE) -- Novoheart (Novoheart or the Company) (TSXV: NVH; FWB: 3NH), a global stem cell biotechnology company, is pleased to announce a collaboration with global biopharmaceutical company AstraZeneca, in an effort to develop the worlds first human-specific in vitro, functional model of heart failure with preserved ejection fraction (HFpEF), a common condition especially among the elderly and in women, with the reported prevalence approaching 10% in women over the age of 80 years.1
Heart failure (HF) is a global pandemic with an estimated 64.3 million cases worldwide in 2017, with an increasing trend in prevalence2. The annual global economic burden of HF is estimated at over US$100 billion3. Accounting for approximately 50% of HF cases, HFpEF in particular is a major and growing public health problem worldwide, with its pathological mechanisms and diverse etiology poorly understood. Due to these complexities, models of the disease available to date, including various animal models, have limited ability to mimic the clinical presentation of HFpEF4. Therefore, drug developers lack an effective tool for preclinical testing of drug candidates for efficacy, and as a result, clinical outcomes for HFpEF have not improved over the last decades, with no effective therapies available.
In collaboration with the Cardiovascular, Renal and Metabolism therapy area of AstraZeneca, the initial phase of the project aims to establish a new in vitro model, leveraging Novohearts proprietary 3-D human ventricular cardiac organoid chamber (hvCOC) technology, that reproduces key phenotypic characteristics of HFpEF. Also known as human heart-in-a-jar, the hvCOC is the only human engineered heart tissue available on the market to date that enables clinically informative assessment of human cardiac pump performance including ejection fraction and developed pressure. Unlike animal models, engineered hvCOCs can be fabricated with specific cellular and matrix compositions, and patient-specific human induced pluripotent stem cells (iPSCs), that allow control over their physical and mechanical properties to mimic those observed in HFpEF patient hearts. Together with Novohearts proprietary hardware and software, this aims to provide a unique assay for understanding the mechanisms of HFpEF, identification of new therapeutic targets, and assessment of novel therapeutics for treating HFpEF patients. Novoheart will exclusively own the intellectual property rights to the newly developed HFpEF hvCOC model.
We are delighted to partner with AstraZeneca, an organization which has long invested in cardiovascular research and is committed to bringing new therapeutic solutions to patients with heart failure, said Novoheart CSO, Dr. Kevin Costa. We look forward to co-developing this new HFpEF hvCOC model into a powerful new tool in the worldwide battle against heart failure.
Regina Fritsche Danielson, Senior Vice President, Head of Research and Early Development, Cardiovascular, Renal and Metabolism, BioPharmaceuticals R&D, AstraZeneca, said, There are significant unmet treatment needs in patients with heart failure with preserved ejection fraction. By combining Novohearts proprietary hvCOC model with our expertise in heart failure, we aim to create the first in vitro model reproducing phenotypic characteristics of heart failure with preserved ejection fraction. This could bridge the gap between in vivo animal models and clinical trials to help accelerate the drug discovery process by providing human-specific preclinical data.
1 Heart Fail Clin. 2014; 10(3):377388.2 Lancet. 2018; 392:1789-1858.3 Int J Cardiol. 2014; 171(3):368-76.4 JACC Basic Transl Sci. 2017; 2(6):770-789.
About Novoheart:
Novoheart is a global stem cell biotechnology company pioneering an array of next-generation human heart tissue prototypes. It is the first company in the world to have engineered miniature living human heart pumps that can revolutionize drug discovery, helping to save time and money for developing new therapeutics. Also known as 'human heart-in-a-jar', Novohearts bio-artificial human heart constructs are created using state-of-the-art and proprietary stem cell and bioengineering approaches and are utilized by drug developers for accurate preclinical testing of the effectiveness and safety of new drugs, maximizing the successes in drug discovery whilst minimizing costs and harm caused to patients. With the recent acquisition of Xellera Therapeutics Limited for manufacturing Good Manufacturing Product (GMP)-grade clinical materials, Novoheart is now developing gene- and cell-based therapies as well as next-generation therapeutics for cardiac repair or regeneration.
For further information, please contact:Ronald Li, CEOinfo@novoheart.com
For media enquiries or interviews, please contact:Media Relationsmedia@novoheart.com
Neither TSX Venture Exchange nor its Regulation Services Provider (as that term is defined in the policies of the TSX Venture Exchange) accepts responsibility for the adequacy or accuracy of this release.
Cautionary Note Regarding Forward-Looking Statements
Information set forth in this news release may involve forward-looking statements under applicable securities laws. Forward-looking statements are statements that relate to future, not past, events. In this context, forward-looking statements often address expected future business and financial performance, and often contain words such as "anticipate", "believe", "plan", "estimate", "expect", and "intend", statements that an action or event "may", "might", "could", "should", or "will" be taken or occur, or other similar expressions. By their nature, forward-looking statements involve known and unknown risks, uncertainties and other factors which may cause the actual results, performance or achievements, or other future events, to be materially different from any future results, performance or achievements expressed or implied by such forward-looking statements. Such factors include, among others, the risks identified in under the heading Risk Factors in Novohearts annual information form for the year ended June 30, 2019 or other reports and filings with the TSX Venture Exchange and applicable Canadian securities regulators. Forward-looking statements are made based on management's beliefs, estimates and opinions on the date that statements are made and the respective companies undertakes no obligation to update forward-looking statements if these beliefs, estimates and opinions or other circumstances should change, except as required by applicable securities laws. Investors are cautioned against attributing undue certainty to forward-looking statements.
Read the original here:
Novoheart to Co-develop First of its Kind Human Heart-in-a-Jar Model of Heart Failure with AstraZeneca - GlobeNewswire
- The Beating Heart (Cardiac) Cells [Last Updated On: June 24th, 2011] [Originally Added On: June 24th, 2011]
- cellalign [Last Updated On: June 24th, 2011] [Originally Added On: June 24th, 2011]
- Okamoto placenta-derived cardiomyocytes [Last Updated On: June 25th, 2011] [Originally Added On: June 25th, 2011]
- Cardiac Stem Cell Therapy [Last Updated On: June 26th, 2011] [Originally Added On: June 26th, 2011]
- Wow! UW Research labs [Last Updated On: June 26th, 2011] [Originally Added On: June 26th, 2011]
- Cardiac Stem Cell Therapy [Last Updated On: June 28th, 2011] [Originally Added On: June 28th, 2011]
- cellalign [Last Updated On: July 3rd, 2011] [Originally Added On: July 3rd, 2011]
- Insidermedicine In 60 - August 4, 2011 [Last Updated On: August 25th, 2011] [Originally Added On: August 25th, 2011]
- Cardiac Stem Cells in End-Stage Human Failing Hearts: Are they functional? [Last Updated On: August 28th, 2011] [Originally Added On: August 28th, 2011]
- Did you have a Heart Attack and Need to Recover your Cardiac Muscle? [Last Updated On: September 5th, 2011] [Originally Added On: September 5th, 2011]
- Heart repair using own stem cells after heart attack: Future Health keynote speaker [Last Updated On: September 5th, 2011] [Originally Added On: September 5th, 2011]
- Cardiac Stem Cell Therapy at Rostock University [Last Updated On: September 5th, 2011] [Originally Added On: September 5th, 2011]
- Cardiovascular Therapies: Spotlight on Stem Cell Research - Douglas Boyd [Last Updated On: September 5th, 2011] [Originally Added On: September 5th, 2011]
- Davos Question: Stem Cell Answer [Last Updated On: September 5th, 2011] [Originally Added On: September 5th, 2011]
- Stem Cell operation in Cardiac Surgery-Al-Jazeerah [Last Updated On: September 6th, 2011] [Originally Added On: September 6th, 2011]
- Stem Cell Therapy in Cardiac Disease [Last Updated On: September 6th, 2011] [Originally Added On: September 6th, 2011]
- Designer Life: repair brain, heart with stem cells - Future Health keynote speaker [Last Updated On: September 7th, 2011] [Originally Added On: September 7th, 2011]
- Stem Cells: Mending a broken heart? [Last Updated On: September 7th, 2011] [Originally Added On: September 7th, 2011]
- Cardiac Stem Cells in End-Stage Human Failing Hearts: Are they functional? [Last Updated On: September 8th, 2011] [Originally Added On: September 8th, 2011]
- Oral Surgeon utilizes StemSave to preserve stem cells in wisdom teeth to combat cardiac disease [Last Updated On: September 9th, 2011] [Originally Added On: September 9th, 2011]
- Cardiac Recovery Points to Adult Stem Cells [Last Updated On: September 9th, 2011] [Originally Added On: September 9th, 2011]
- Oral Surgeon utilizes StemSave to preserve stem cells in wisdom teeth to combat cardiac disease [Last Updated On: September 10th, 2011] [Originally Added On: September 10th, 2011]
- Stem Cell operation in Cardiac Surgery-Al-Jazeerah [Last Updated On: September 10th, 2011] [Originally Added On: September 10th, 2011]
- Cardiovascular Derivatives of Embryonic Stem Cells in Cardiac Repair and Drug Discovery [Last Updated On: September 10th, 2011] [Originally Added On: September 10th, 2011]
- Stem Cell Therapy in Cardiac Disease [Last Updated On: September 11th, 2011] [Originally Added On: September 11th, 2011]
- Cardiovascular Derivatives of Embryonic Stem Cells in Cardiac Repair and Drug Discovery [Last Updated On: September 12th, 2011] [Originally Added On: September 12th, 2011]
- Stem Cells and Cardiac Regeneration [Last Updated On: September 12th, 2011] [Originally Added On: September 12th, 2011]
- Cardiomyogenic differentiation of Mesenchymal Stem cells (KUM2/9-15c) [Last Updated On: September 12th, 2011] [Originally Added On: September 12th, 2011]
- Mark Mercola: Differentiating embryonic stem cells into adult tissues [Last Updated On: September 15th, 2011] [Originally Added On: September 15th, 2011]
- Cardiovascular Therapies: Spotlight on Stem Cell Research - Douglas Boyd [Last Updated On: September 20th, 2011] [Originally Added On: September 20th, 2011]
- Stem Cell #8 Vas Cath Removal 04/28/11 [Last Updated On: September 20th, 2011] [Originally Added On: September 20th, 2011]
- Adult Stem Cells Used To Rebuild Heart Tissue Video. More at http://www.stemcellfusion.com [Last Updated On: September 20th, 2011] [Originally Added On: September 20th, 2011]
- Stem Cell Therapy and Stem Cell Treatment with Dell [Last Updated On: September 23rd, 2011] [Originally Added On: September 23rd, 2011]
- First US Patient In Stem Cell Transplant [Last Updated On: September 23rd, 2011] [Originally Added On: September 23rd, 2011]
- Stem Cell Heart Surgery must see [Last Updated On: September 23rd, 2011] [Originally Added On: September 23rd, 2011]
- Beating cardiac myocytes from differentiated mouse iPSC. [Last Updated On: September 23rd, 2011] [Originally Added On: September 23rd, 2011]
- heart cell generation from human ES and iPS cells (embryonic and induced pluripotent stem cells).flv [Last Updated On: September 23rd, 2011] [Originally Added On: September 23rd, 2011]
- Advanced Cell Technology OneMedForum 2011 [Last Updated On: September 23rd, 2011] [Originally Added On: September 23rd, 2011]
- 20100804_axiogenesis.wmv [Last Updated On: September 23rd, 2011] [Originally Added On: September 23rd, 2011]
- Pt. 1--Dr. Ali Denktas--Stem Cells as Markers after Myocardial Infarctions [Last Updated On: September 23rd, 2011] [Originally Added On: September 23rd, 2011]
- Cardiac Tissue Can Regenerate [Last Updated On: September 23rd, 2011] [Originally Added On: September 23rd, 2011]
- Adult Stem Cell [Last Updated On: September 23rd, 2011] [Originally Added On: September 23rd, 2011]
- Beating cardiomyocyte monolayer [Last Updated On: September 23rd, 2011] [Originally Added On: September 23rd, 2011]
- Valentine's Day Stem Cell Wish: Mending Broken Hearts [Last Updated On: September 23rd, 2011] [Originally Added On: September 23rd, 2011]
- Cardiomyocytes derived from mouse Embryonic stem cells [Last Updated On: September 24th, 2011] [Originally Added On: September 24th, 2011]
- UCD Med Student Receives Fulbright Award [Last Updated On: September 24th, 2011] [Originally Added On: September 24th, 2011]
- Mouse GEN cells overexpressing Csx/Nkx2.5 and GATA4 behave like transient amplifying cells [Last Updated On: September 24th, 2011] [Originally Added On: September 24th, 2011]
- 2010 - 2011 UConn Highlight Reel [Last Updated On: September 24th, 2011] [Originally Added On: September 24th, 2011]
- William F. Testimonial of Treatment Stem Cell [Last Updated On: September 24th, 2011] [Originally Added On: September 24th, 2011]
- BeatingCM_on_MEA.wmv [Last Updated On: September 24th, 2011] [Originally Added On: September 24th, 2011]
- Breakthrough in Stem cell technology [Last Updated On: September 25th, 2011] [Originally Added On: September 25th, 2011]
- stem cell derived cardiomyocytes [Last Updated On: September 25th, 2011] [Originally Added On: September 25th, 2011]
- Mark Mercola: Differentiating embryonic stem cells into adult tissues [Last Updated On: September 25th, 2011] [Originally Added On: September 25th, 2011]
- Cadiomyogenesis of human mesenchymal stem cells [Last Updated On: September 25th, 2011] [Originally Added On: September 25th, 2011]
- Adult Stem Cell vs Embryonic Stem Cell Research Ethics Video [Last Updated On: September 25th, 2011] [Originally Added On: September 25th, 2011]
- Heart Failure Patient After Adult Stem Cell Therapy [Last Updated On: September 25th, 2011] [Originally Added On: September 25th, 2011]
- Affordable Stem Cell Therapy in Guatemala (2hrs from Miami) [Last Updated On: September 25th, 2011] [Originally Added On: September 25th, 2011]
- Kevin's 2 Heart Transplants and Stem Cell Transplant [Last Updated On: September 25th, 2011] [Originally Added On: September 25th, 2011]
- Immune Control of Stem Cell Mobilization [Last Updated On: September 25th, 2011] [Originally Added On: September 25th, 2011]
- Patel Stem Cell Heart Failure [Last Updated On: September 25th, 2011] [Originally Added On: September 25th, 2011]
- Better Drugs Through Stem Cells [Last Updated On: September 25th, 2011] [Originally Added On: September 25th, 2011]
- Heart Disease Patient Describes His Stem Cell Treatment [Last Updated On: September 25th, 2011] [Originally Added On: September 25th, 2011]
- Turning Adult Stem Cells into Medicine - Zannos Grekos, MD [Last Updated On: September 25th, 2011] [Originally Added On: September 25th, 2011]
- Cardiomyocytic differentiation of endometrial stem cells. [Last Updated On: September 26th, 2011] [Originally Added On: September 26th, 2011]
- Turning Adult Stem Cells into Medicine - Zannos Grekos, MD [Last Updated On: September 26th, 2011] [Originally Added On: September 26th, 2011]
- Stem Cells: Heart cells grown from mouse stem cells [Last Updated On: September 26th, 2011] [Originally Added On: September 26th, 2011]
- Beating cells [Last Updated On: September 28th, 2011] [Originally Added On: September 28th, 2011]
- Repairing Damaged Hearts with Stem Cells [Last Updated On: September 28th, 2011] [Originally Added On: September 28th, 2011]
- Heart cells grown from human embryonic stem cells [Last Updated On: September 28th, 2011] [Originally Added On: September 28th, 2011]
- CytoTune iPSCs - Cardiomyocytes [Last Updated On: September 29th, 2011] [Originally Added On: September 29th, 2011]
- Becoming Bionic: The Little Book of Hope for Heart Patients Runblog ("Dress the Part") [Last Updated On: September 29th, 2011] [Originally Added On: September 29th, 2011]
- H9 Cardiac EBs.mov [Last Updated On: September 29th, 2011] [Originally Added On: September 29th, 2011]
- Beating Cardiomyocytes from E14 Cells [Last Updated On: September 29th, 2011] [Originally Added On: September 29th, 2011]
- Human 2.0: The Helix of Our Future [Last Updated On: September 30th, 2011] [Originally Added On: September 30th, 2011]
- Beating Human Heart Cells from Embryonic Stem Cells [Last Updated On: October 1st, 2011] [Originally Added On: October 1st, 2011]
- Be still my beating stem cell heart [Last Updated On: October 1st, 2011] [Originally Added On: October 1st, 2011]
- Doctors To Use 'Trained' Stem Cells To Heal Heart [Last Updated On: October 2nd, 2011] [Originally Added On: October 2nd, 2011]
- Spontaneously and rhythmically beating engineered human heart tissue from pluripotent stem cells [Last Updated On: October 3rd, 2011] [Originally Added On: October 3rd, 2011]
- Cardiac Stem Cell Therapy - How it works [Last Updated On: October 4th, 2011] [Originally Added On: October 4th, 2011]
- Doctors To Use 'Trained' Stem Cells To Heal Heart [Last Updated On: October 4th, 2011] [Originally Added On: October 4th, 2011]