Archive for the ‘Cell Medicine’ Category

PUBLIC RELEASE DATE:

4-Dec-2013

Contact: David Hajime Kornhauser david@icems.kyoto-u.ac.jp 81-757-539-748 Elsevier

San Diego, December 4, 2013 Elsevier, EuroStemCell, and Kyoto University's Institute for Integrated Cell-Material Sciences (iCeMS), today released "Stem Cell Research report: Trends and Perspectives on the Evolving International Landscape" at the World Stem Cell Summit. This new, comprehensive analysis of the growth and development of the stem cell field as a whole, closely examines the research landscape for embryonic stem (ES) cell, human embryonic stem (hES) cell and induced pluripotent stem (iPS) cell.

In order to provide a broad and transparent data driven view of the field, the study reviewed leading nations' research output, citation impact and collaboration behavior, as well as assessing international differences in focus and growth. The report combines a comprehensive publication analysis from Elsevier's Scopus, the largest scientific abstract and citation database, together with scientists' and other stakeholders' views on current progress and future expectations of the field. Findings will be presented at the World Stem Cell Summit and discussed by Stephen Minger (GE Healthcare), Norio Nakatsuji (Kyoto University iCeMS), Brock C. Reeve (Harvard Stem Cell Institute), Deborah J. Sweet (Cell Press) and Brad Fenwick (Elsevier) on the 6th December.

Highlights and key findings of the report include:

Stem cell research holds great potential to revolutionize healthcare. Investments into this field strive to deliver new treatments for many serious conditions for which few effective treatments currently exist. Some basic research findings are being translated into new treatments, and with the discovery of induced pluripotent stem cells in 2006, the field has seen a step-change in biological understanding that will affect the way new drugs are identified and tested and, potentially, the way cells can be generated in the lab. While the field has attracted priority status in many countries, it has also been the focus of continuous discussion around ethics and regulation with each nation taking its own policy position, some of which have had a clear effect on the dynamics of the field.

"The challenge for the coming decade is to expand on multi-disciplinary and multi-sector collaboration aimed at large-scale production of high-quality human pluripotent stem cells, and also, robust and reliable production of high-quality differentiated cells", said Professor Norio Nakatsuji, Founding Director of Kyoto University, iCeMS. "In order to provide adequate support to accelerate such research, a nation should take an evidence-based approach with an understanding of the global trend from a multitude of perspectives."

"This report gives us a bird's eye view of the international stem cell field, drawing on advanced bibliometric techniques to identify national and international trends where is stem cell research strongest, where is the sector developing fastest, are the results of individual funding initiatives translating into high impact publications, and so on," said Professor Clare Blackburn, MRC Centre for Regenerative Medicine, University of Edinburgh and the Project Coordinator of EuroStemCell. "It has been extremely interesting to analyse these data, they contain a lot of provocative information. We hope readers will gain a new understanding of the shape of the field that will stimulate future policy discussions."

Nick Fowler, Managing Director of Academic and Government Institutions for Elsevier, said, "The aim of this report was to support development in stem cell science and policy discussion by bringing together comprehensive analytical overview of the fields together with insights from experts. We are proud we have been able to collaborate with EuroStemCell, Kyoto University, iCeMS and the experts who have provided their valuable input."

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New report on stem cell research reveals the field is growing ...

Frederick, MD (PRWEB) November 28, 2013

Dr. Jon Rowley and Dr. Uplaksh Kumar, Co-Founders of RoosterBio, Inc., a newly formed biotech startup located in Frederick, are paving the way for even more innovation in the rapidly growing fields of Synthetic Biology and Regenerative Medicine. Synthetic Biology combines engineering principles with basic science to build biological products, including regenerative medicines and cellular therapies. Regenerative medicine is a broad definition for innovative medical therapies that will enable the body to repair, replace, restore and regenerate damaged or diseased cells, tissues and organs. Regenerative therapies that are in clinical trials today may enable repair of damaged heart muscle following heart attack, replacement of skin for burn victims, restoration of movement after spinal cord injury, regeneration of pancreatic tissue for insulin production in diabetics and provide new treatments for Parkinsons and Alzheimers diseases, to name just a few applications.

While the potential of the field is promising, the pace of development has been slow. One main reason for this is that the living cells required for these therapies are cost-prohibitive and not supplied at volumes that support many research and product development efforts. RoosterBio will manufacture large quantities of standardized primary cells at high quality and low cost, which will quicken the pace of scientific discovery and translation to the clinic. Our goal is to accelerate the development of products that incorporate living cells by providing abundant, affordable and high quality materials to researchers that are developing and commercializing these regenerative technologies says Dr. Rowley.

RoosterBios current focus is to supply high volume research-grade cells manufactured with processes consistent with current Good Manufacturing Practices (cGMP). These cells will be used for tissue engineering research and cell-based product development. This will position RoosterBio to quickly move on to producing clinical-grade cells to be used in translational R&D and clinical studies.

We have spent almost 20 years as cell and tissue technologists and have lived with the pain of needing to generate large amounts of cells for experiments this whole time. RoosterBio was founded to address this problem for cell and tissue engineers, saving them time and money, and accelerating their path to the clinic, says Dr. Rowley. RoosterBio will supply cells, starting with adult human bone marrow-derived stem cells, at volumes that will allow for a more rapid pace of experimentation in the lab.

We will also offer paired media that has been engineered to quickly and efficiently expand the supplied cells to hundreds of millions or billions of cells within 1-2 weeks, something that would take 4-8 weeks using cell and media systems currently on the market, adds Dr. Kumar. We aim to usher in a new era of productivity to the field, and we believe that our products will at least triple the efficiency of the average laboratory.

RoosterBio, Inc. is located in the Frederick Innovative Technology Center on Metropolitan Court in Frederick. Dr. Rowley entered into the incubation program in October of this year, and already gained four full time employees, and has several academic and industrial collaborators lined up. This team has made remarkable progress and are already poised for their official product launch for their human bone marrow-derived Mesenchymal Stem Cells (hBM-MSC), anticipated in March 2014.

RoosterBios product formats have been extraordinarily well received by the market, and RoosterBio has already secured customers who are anxiously awaiting their product launch. "I am excited to see that someone is taking on the challenge of providing a sufficient number of MSCs to immediately start experiments upon their receipt. This saves us several weeks of time upfront waiting for cells to expand to volumes that allow us to begin experiments, says Todd McDevitt, Director of the Stem Cell Engineering Center at the Georgia Institute of Technology. For tissue engineering folks like myself, this means we can focus our time on high priority research questions and not spend the majority of our time performing routine cell culture."

The Tissue Engineering and Regenerative Medicine industry is one of the fastest growing in the life science sector with the total expenditure in 2011 at $17.1 billion. This number is expected to increase in 2020 to $40.5 billion. The sales of stem cell products accounted for $1.38 billion in 2010 and is expected to reach $3.9 billion by the year 2014 and $8 billion in annual revenues by 2020.

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Startup to Strengthen Synthetic Biology and Regenerative ...

T he International Cellular Medicine Society (ICMS) is an international non-profit dedicated to patient safety through strict evaluation of protocols and rigorous oversight of clinics and facilities engaged in the translation of point-of-care cell-based treatments.As a Professional Medical Association, the ICMS represents Physiciansand Researchersfrom over 35 countries who share a mission to provide Scientifically Credible and Medically Appropriate Treatments to Informed Patients.Join the ICMS.

The ICMS Works Tirelessly for the Clincial Translation of Field of Cell-Based Point-of-Care Treatments through:

Comprehensive Medical Standards and Best Practice Guidelines for Cell Based Medicine,

Strict Evaluation and Rigerous Oversight of Stem Cell Clinics and Facilities through aGlobal Accreditation Process,

Physician Education through daily updates on the latest Research on Stem Cells, the monthly Currents In Stem Cell Medicine and the annual International Congress for Regenerative and Stem Cell Medicine.

Join the ICMSto receive the latest news and research from cell-based medicne, including the bi-monthly publication, Currents in Stem Cell Medicine.

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ICMS International Cell Medicine Society

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This website http://www.cellmedicine.com offers patients, doctors and scientists the opportunity to connect to licensed doctors who use adult stem cells as part of their clinical practice outside of the United States and Canada. Because stem cell therapy is not the standard of care in the US or Canada, the following important disclosures are made:

1) The Stem Cell Institute is not conducting free clinical trials at this time. 2) Health insurance will not cover the treatment fees. 3) The Stem Cell Institute does not provide itemized bills.

Treatments include from 3 to 16 separate stem cell infusions/injections over the course of 4 to 30 days depending upon the protocol employed. A fee will be quoted once your treatment protocol has been determined.

We do not treat ALS, Alzheimers, muscular dystrophy or stroke.

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Home >> Publication: Cell Medicine

The importance of translating original, peer-reviewed research and review articles on the subject of cell therapy and its application to human diseases to society has led to the formation of the journal Cell Medicine. To ensure high-quality contributions from all areas of transplantation, the same rigorous peer review will be applied to articles published in Cell Medicine. Articles may deal with a wide range of topics including physiological, medical, preclinical, tissue engineering, and device-oriented aspects of transplantation of nervous system, endocrine, growth factor-secreting, bone marrow, epithelial, endothelial, and genetically engineered cells, and stem cells, among others. Basic clinical studies and immunological research papers may also be featured if they have a translational interest. To provide complete coverage of this revolutionary field, Cell Medicine will report on relevant technological advances and their potential for translational medicine. Cell Medicine will be a purely online Open Access journal. There will therefore be an inexpensive publication charge, which is dependent on the number of pages, in addition to the charge for color figures. This will allow your work to be disseminated to a wider audience and also entitle you to a free PDF, as well as prepublication of an unedited version of your manuscript.

Publisher: Cognizant Communication Corporation

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ingentaconnect Publication: Cell Medicine

This article is about the medical therapy. For the cell type, see Stem cell.

Stem cell therapy is an intervention strategy that introduces new adult stem cells into damaged tissue in order to treat disease or injury. Many medical researchers believe that stem cell treatments have the potential to change the face of human disease and alleviate suffering.[1] The ability of stem cells to self-renew and give rise to subsequent generations with variable degrees of differentiation capacities,[2] offers significant potential for generation of tissues that can potentially replace diseased and damaged areas in the body, with minimal risk of rejection and side effects.

A number of stem cell therapies exist, but most are at experimental stages, costly or controversial,[3] with the notable exception of bone-marrow transplantation.[citation needed] Medical researchers anticipate that adult and embryonic stem cells will soon be able to treat cancer, Type 1 diabetes mellitus, Parkinson's disease, Huntington's disease, Celiac disease, cardiac failure, muscle damage and neurological disorders, and many others.[4] Nevertheless, before stem cell therapeutics can be applied in the clinical setting, more research is necessary to understand stem cell behavior upon transplantation as well as the mechanisms of stem cell interaction with the diseased/injured microenvironment.[4]

For over 30 years, bone-marrow, and more recently, umbilical-cord blood stem cells, have been used to treat cancer patients with conditions such as leukemia and lymphoma.[5][6] During chemotherapy, most growing cells are killed by the cytotoxic agents. These agents, however, cannot discriminate between the leukaemia or neoplastic cells, and the hematopoietic stem cells within the bone marrow. It is this side effect of conventional chemotherapy strategies that the stem cell transplant attempts to reverse; a donor's healthy bone marrow reintroduces functional stem cells to replace the cells lost in the host's body during treatment.

Stroke and traumatic brain injury lead to cell death, characterized by a loss of neurons and oligodendrocytes within the brain. Healthy adult brains contain neural stem cells which divide to maintain general stem cell numbers, or become progenitor cells. In healthy adult animals, progenitor cells migrate within the brain and function primarily to maintain neuron populations for olfaction (the sense of smell). In pregnancy and after injury, this system appears to be regulated by growth factors and can increase the rate at which new brain matter is formed.[citation needed] Although the reparative process appears to initiate following trauma to the brain, substantial recovery is rarely observed in adults, suggesting a lack of robustness.[7]

Stem cells may also be used to treat brain degeneration, such as in Parkinson's and Alzheimer's disease.[8][9]

Pharmacological activation of an endogenous population of neural stem cells / neural precursor cells by soluble factors has been reported to induce powerful neuroprotection and behavioral recovery in adult rat models of neurological disorder through a signal transduction pathway involving the phosphorylation of STAT3 on the serine residue and subsequent Hes3 expression increase (STAT3-Ser/Hes3 Signaling Axis).[10][11][12]

Stem cell technology gives hope of effective treatment for a variety of malignant and non-malignant diseases through the rapid developing field that combines the efforts of cell biologists, geneticists and clinicians. Stem cells are defined as totipotent progenitor cells capable of self-renewal and multi-lineage differentiation. Stem cells survive well and show steady division in culture which then causes them the ideal targets for vitro manipulation. Research into solid tissue stem cells has not made the same progress as haematopoietic stem cells because of the difficulty of reproducing the necessary and precise 3D arrangements and tight cell-cell and cell-extracellular matrix interactions that exist in solid organs. Yet, the ability of tissue stem cells to assimilate into the tissue cytoarchitecture under the control of the host microenvironment and developmental cues, makes them ideal for cell replacement therapy. [3] [13]

The development of gene therapy strategies for treatment of intra-cranial tumours offers much promise, and has shown to be successful in the treatment of some dogs;[14] although research in this area is still at an early stage. Using conventional techniques, brain cancer is difficult to treat because it spreads so rapidly. Researchers at the Harvard Medical School transplanted human neural stem cells into the brain of rodents that received intracranial tumours. Within days, the cells migrated into the cancerous area and produced cytosine deaminase, an enzyme that converts a non-toxic pro-drug into a chemotheraputic agent. As a result, the injected substance was able to reduce the tumor mass by 81 percent. The stem cells neither differentiated nor turned tumorigenic.[15]

Some researchers believe that the key to finding a cure for cancer is to inhibit proliferation of cancer stem cells. Accordingly, current cancer treatments are designed to kill cancer cells. However, conventional chemotherapy treatments cannot discriminate between cancerous cells and others. Stem cell therapies may serve as potential treatments for cancer.[16] Research on treating lymphoma using adult stem cells is underway and has had human trials. Essentially, chemotherapy is used to completely destroy the patients own lymphocytes, and stem cells injected, eventually replacing the immune system of the patient with that of the healthy donor.

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Stem cell therapy - Wikipedia, the free encyclopedia

The Journal of Stem cells and Regenerative Medicine (JSRM) is a fully free access exclusive Online Journal covering areas of Basic Research, Translational work and Clinical studies in the specialty of Stem Cells and Regenerative Medicine including allied specialities such as Biomaterials and Nano technology relevant to the core subject. This has also been endorsed by the German Society for Stem Cell Research(GSZ).

The JSRM issues are published regularly and articles pertaining to Stem cells and Regenerative Medicine as well as related fields of research are considered for publication

This Online Journal conceived and run by Clinicians and Scientists, originally started for the student community with reputed members in the advisory/editorial boards, has now been accepted to be the official organ of GSZ is reaching millions of Researchers, Cliniciansand Students all over the world, as it is a FREE Journal

Current activities of JSRM

1. Journal issues: will be published online and to subscribers (FREE) extracts will be sent by email 2. Weekly updates on happenings in the Stem Cell World with email updates to subscribers.

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Journal of Stem cells & Regenerative Medicine; JSRM- ISSN Number ...

Aims & Scope

The importance of translatingoriginal, peer-reviewed research and review articles on the subject of cell therapy and its application to human diseases to societyhas led to the formation ofthe journalCell Medicine. To ensure high-quality contributions from all areas of transplantation, the same rigorous peer review will be applied to articles published in Cell Medicine. Articles may deal with a wide range of topics including physiological, medical, preclinical, tissue engineering, and device-oriented aspects of transplantation of nervous system, endocrine, growth factor-secreting, bone marrow, epithelial, endothelial, and genetically engineered cells, and stem cells, among others. Basic clinical studies and immunological research papers may also be featured if they have a translational interest. To provide complete coverage of this revolutionary field, Cell Medicine will report on relevant technological advances and their potential for translational medicine. Cell Medicine will be a purely online Open Access journal. There will therefore be an inexpensive publication charge, which is dependent on the number of pages, in addition to the charge for color figures. This will allow your work to be disseminated to a wider audience and also entitle you to a free PDF, as well as prepublication of an unedited version of your manuscript.

Cell Medicine features:

Original Contributions: Peer-reviewed, high-quality research investigations that represent new and significant contributions to science. Review Articles: Reviews of major areas in cellular transplantation. These may be of any length and are peer reviewed. Brief Communications: Timely and brief peer-reviewed studies. Letters to the Editor: Readers' comments on journal articles and other matters of interest to transplant researchers. Announcements and News: Notices of upcoming meetings, conferences, seminars, and other events of interest to those in the field.

Submission Requirements: From the beginning of November 2009, authors are requested to submit the original manuscript (and revised manuscript if needed) via our ManuscriptCentral websiteat http://mc.manuscriptcentral.com/cogcom-ct.

Please include a cover letter, specifying your intent to submit to Cell Medicine, as well as containing the name, address, telephone, and fax number, and electronic mail address of the author responsible for correspondence. Follow the General Form guidelines below to prepare the manuscript, figures, and tables.

At the time of submission you will be asked to confirm that you will pay the relatively inexpensive open access fees ($900 for less than 5 pages, $1800 for 5-12 pages and +$75 for each additional page) when billed. In addition, there are sections for detailing any conflicts of interest and financial support and that you (as corresponding/submitting author) have the permission of the other authors to submit the manuscript. You will be given the option of which section of the editorial office to submit to. Here you would select Cell Medicine.

There will also be a $105 submission fee.

On receipt of your manuscript, it will be checked to ensure that it is correctly formatted.

When the manuscript is accepted for publication, the author(s) will be required to provide two hard copies of the manuscript, two high-quality copies of all artwork, and a CD or disk (no zip disks) (see Final Accepted Manuscript/Disk below). Information on where to mail the final hard copy, figures, and CD/disk will be provided in an acceptance letter. Manuscripts are accepted for consideration with the understanding that they have not been published elsewhere except in abstract form and are not concurrently under review elsewhere.

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Cell Medicine - Cognizant Communication Corporation

Two organizations of Filipino medical practitioners - the Philippine Medical Association (PMA) and the Philippine Society for Stem Cell Medicine (PSSCM) - are partnering to come up with ideas to help professionalize and organize the practice of stem cell therapy in the Philippines during their 1st Midyear Convention at the Historic Landmark Manila Hotel on August 12-13, 2013.

With the theme ''Current Status of the Practice of Stem Cell Therapy in the Philippines,'' the convention is expected to take up various issues surrounding stem cell therapy, which, despite the controversies, is increasingly becoming popular for treatment of certain illnesses. Among the scheduled topics for discussion in the convention are Food and Drug Administration Circular on Stem Cell Products, DOH Stem Cell Guidelines, Current Trends on Stem Cell Therapy, Clinical Use of Autologous, Adipose Derived Stem Cells, Photo-Activated Platelet-Rich Plasma for Orthopedic and Rehabilitation Applications, Umbilical Cord Blood and Cord Tissue for Stem Cell Therapy, Stem Cell Therapy in the Philippines other than for Cancer Rejuvenation, and Quality Control in Cell Transplantation.

Administrative Order 2013-0012 issued by the Department of Health (DOH) rules on the practice of stem cell, cell-based therapy, and accreditation of health facilities engaging in the treatment in the Philippines. The Professional Regulation Commission Board of Medicine (PRCBOM) requires foreign doctors wishing to practice stem cell therapy in the country to get a special temporary permit, citing their education, training, and clinical experience.

The PMA, the country's premier medical organization, has 70,000 members in 118 component medical societies, eight specialty divisions, 73 specialty and subspecialty societies, and 39 affiliate societies all over the archipelago, who advocate professional advancement and promote public health. The newly founded PSSCM is composed of physicians doing stem cell therapy and transplant. It is working closely with DOH, PRCBOM, and PMA to regulate the practice of Stem Cell therapy and protect patients.

We congratulate the Philippine Medical Association, headed by its President Dr. Leo O. Olarte, and the Philippine Society for Stem Cell Medicine, led by Dr. Rey Melchor F. Santos, in their coordinative efforts to educate and inform the public on the status of stem cell treatment as a novel medical approach in the Republic of the Philippines. CONGRATULATIONS AND MABUHAY!

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Editorial: Philippine Society for Stem Cell Medicine and Philippine Medical Association 1st Midyear Convention to be ...

THE Philippine Society for Stem Cell Medicine has brought early March a technology in Iloilo City in a bid to promote stem cell medicine and therapy.

Mayor Jed Patrick Mabilog said the arrival of the stem cell medicine in Iloilo would attract tourists and for physicians to practice in the city.

Mabilog said aside from stem cell medicine, Iloilo City is ready to absorb other branches of science such as in-vitro fertilization and cryogenic as several hospitals have adequate facilities, specialist doctors and trained personnel to offer.

In Iloilo City alone, there are seven private tertiary hospitals and one government medical center, seven district health centers and more than 100 barangay health centers out of the 180 barangays, more than 20 private health service providers on top of private medical practitioners with their own clinics.

Society president Dr. Leo Olarte said a memorandum of agreement (MOA) will be forged between the association and St. Pauls Hospital here for the acceptance of the program and put up a stem cell center to serve the needs of the Ilonggos.

Olarte said stem cell medicine is a new wonder medicine and the cure of the future. Its successful effects had stemmed the tide of several devastating diseases today and it is considered a good cure for multiple sclerosis, Parkinsons disease, even tuberculosis, diabetes, HIV-Aids and all types of degenerative diseases.

Olarte said although the Department of Health (DOH) has approved the new technology, he warned that harvest of stem cells must be from the human body or the patient himself.

The DOH is expected to issue a guideline on stem cell medicine with the month of March.

The activated stem cells may come from the combined sources of blood, bone marrow and adipose tissue of the patient that maybe operated or injected in three to five hours operation, Olarte said.

The private hospitals operating in the city are Iloilo Doctors Hospital, St. Pauls Hospital, West Visayas University Hospital (Don Benito Hospital), Iloilo Mission Hospital, Medical City, St Therese Hospital and Amoesup International Hospital.

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Stem cell medicine in Iloilo

Manila: A Philippine-based group has aired concern over the dangers of stem cell treatment as it warned of the possibility that materials being used for such procedures could have been extracted from hapless donors, particularly human foetuses.

Dr Leo Olarte, spokesman of the Philippine Society for Stem Cell Medicine, said they were alarmed over reports coming locally and from abroad that some stem cell materials were being taken from the unborn.

At the same time he called on the Department of Health to carefully watch stem cell treatment practitioners. The Catholic Church, he said, should unite with health practitioners and put an end to such practices.

Olarte was quoted as saying in reports that allogenic stem cells from aborted foetuses of humans were being exported to the Philippines.

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We cannot stand by and merely watch how they exploit people in poverty just to profit while allowing others who are economically well off to benefit from this, he said.

He said there were reports that human stem cells from foetuses and female egg cells were being used in anti-ageing procedures and other medical treatments.

Olarte is also concerned over the sale of supposedly stem cell products that come in the form of injectibles and even soaps.

Dont patronise those products. An example is the stem cell soap. It is unfair that stem cell therapy becomes a quackery, he said.

Earlier, Department of Health Secretary Enrique Ona led a national convention participated in by doctors to discuss the truth behind stem cell therapy.

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Philippine-based group warns on stem cell medicine

Keynote Message of Secretary Enrique T. Ona

Philippine Society for Stem Cell Medicine

1st National Convention The Truth and Fallacies about Stem Cell Therapy

January 16, 2013, Pandanggo Hall, Manila Hotel

The establishment of the Philippine Society for Stem Cell Medicine composed of physicians with interest in stem cell therapy is opportune, with the increasing demand for the use of stem cells as therapy in oncology, end organ diseases and regenerative medicine, here now in the Philippines and worldwide. I congratulate the founding members, led by Dr. Jose Sabili, your Chairman and Dr Rey Melchor Santos, your President for recognizing the need to organize and professionalize the practice of stem cell therapy in this country.

This two-day national convention, with the theme The Truth and Fallacies about Stem Cell Therapy is very timely as we in the Department of Health and the medical profession try to clear the air of misinformation and half-truths regarding this popular mode of treatment. We owe it to our patients and the general public to ensure that proper information and guidance regarding this novel medical approach is available. To protect themselves and their loved ones, the public must know the most current and accurate information about stem cells and its various applications, including some of which are purely experimental. We must ensure that only safe and ethical uses of stem cells are being used in the Philippines.

Today, we see the proliferation of centers offering stem cell treatments for medical and aesthetic purposes. Some stem cell programs here have expert personnel and clinical facilities and advanced laboratory equipment and technologies, reputed to be more advanced than other institutions abroad. We are concerned, however, that other facilities might not have the minimum capabilities especially trained personnel staff and equipment needed to perform stem cell therapies safely and effectively.

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Keynote Message of Secretary Enrique T. Ona: Stem Cell Medicine 1st National Convention

Welcome to Hillside Animal Hospital - Scottsdale, AZ
hillsidepets.com - Call us today at (480) 391-7297. At Hillside Animal Hospital, we are committed to providing the best quality patient care available. We are a full service animal hospital and specialize in General Veterinary Care, Surgical, and Stem Cell Medicine. In addition our facility is equipped with Ultrasound, Digital X-Ray, Endoscopy, and Laprascopic Equipment. Our office is located in Scottsdale, AZ and serves the surrounding communities of Paradise Valley and Fountain Hills.From:HillsideAHViews:0 0ratingsTime:01:35More inPets Animals

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Hillside Animal Hospital - Short | Scottsdale, AZ
hillsidepets.com - Call us today at (480) 391-7297. At Hillside Animal Hospital, we specialize in Surgical, General Veterinary Care, and Stem Cell Medicine. In addition our facility is equipped with Endoscopy, Digital X-Ray, Ultrasound, and Laprascopic Equipment. We are located in Scottsdale, AZ and serve the surrounding communities of Paradise Valley and Fountain Hills.From:HillsideAHViews:0 0ratingsTime:00:16More inPets Animals

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When cosmetic surgeon Allan Wu first heard the woman's complaint, he wondered if she was imagining things or making it up. A resident of Los Angeles in her late sixties, she explained that she could not open her right eye without considerable pain and that every time she forced it open, she heard a strange clicka sharp sound, like a tiny castanet snapping shut. After examining her in person at The Morrow Institute in Rancho Mirage, Calif., Wu could see that something was wrong: Her eyelid drooped stubbornly, and the area around her eye was somewhat swollen. Six and a half hours of surgery later, he and his colleagues had dug out small chunks of bone from the woman's eyelid and tissue surrounding her eye, which was scratched but largely intact. The clicks she heard were the bone fragments grinding against one another.

About three months earlier the woman had opted for a relatively new kind of cosmetic procedure at a different clinic in Beverly Hillsa face-lift that made use of her own adult stem cells. First, cosmetic surgeons had removed some the woman's abdominal fat with liposuction and isolated the adult stem cells withina family of cells that can make many copies of themselves in an immature state and can develop into several different kinds of mature tissue. In this case the doctors extracted mesenchymal stem cellswhich can turn into bone, cartilage or fat, among other tissuesand injected those cells back into her face, especially around her eyes. The procedure cost her more than $20,000, Wu recollects. Such face-lifts supposedly rejuvenate the skin because stem cells turn into brand-new tissue and release chemicals that help heal aging cells and stimulate nearby cells to proliferate.

During the face-lift her clinicians had also injected some dermal filler, which plastic surgeons have safely used for more than 20 years to reduce the appearance of wrinkles. The principal component of such fillers is calcium hydroxylapatite, a mineral with which cell biologists encourage mesenchymal stem cells to turn into bonea fact that escaped the woman's clinicians. Wu thinks this unanticipated interaction explains her predicament. He successfully removed the pieces of bone from her eyelid in 2009 and says she is doing well today, but some living stem cells may linger in her face. These cells could turn into bone or other out-of-place tissues once again.

Dozens, perhaps hundreds, of clinics across the country offer a variety of similar, untested stem cell treatments for both cosmetic and medical purposes. Costing between $3,000 and $30,000, the treatments promise to alleviate everything from wrinkles to joint pain to autism. The U.S. Food and Drug Administration (FDA) has not approved any of these treatments and, with a limited budget, is struggling to keep track of all the unapproved therapies on the market. At the same time, pills, oils, creams and moisturizers that allegedly contain the right combination of ingredients to mobilize the body's resident stem cells, or contain chemicals extracted from the stem cells in plants and animals, are popping up in pharmacies and online. There's Stem Cell 100, for example, MEGA STEM and Apple Stem Cell Cloud Cream. Few of these cosmetics have been properly tested in published experiments, yet the companies that manufacture them say they may heal damaged organs, slow or reverse natural aging, restore youthful energy and revitalize the skin. Whether such cosmetics may also produce unintended and potentially harmful effects remains largely unexamined. The increasing number of untested and unauthorized stem cell treatments threaten both people who buy them and researchers hoping to conduct clinical trials for promising stem cell medicine.

When is a skin cream a drug? So far, the FDA has only approved one stem cell treatment: a transplant of bone marrow stem cells for people with the blood cancer leukemia. Among the increasing number of unapproved stem cell treatments, some clearly violate the FDA's regulations whereas others may technically be legal without its approval. In July 2012, for example, the U.S. District Court upheld an injunction brought by the FDA against Colorado-based Regenerative Sciences to regulate just one of the company's several stem cell treatments for various joint injuries as an "unapproved biological drug product." The decision hinged on what constitutes "minimal manipulation" of cells in the lab before they are injected into patients. In the treatment that the FDA won the right to regulate, stem cells are grown and modified in the lab for several weeks before they are returned to patients; in Regenerative Sciences's other treatments, patients' stem cells are extracted and injected within a day or two. Regenerative Sciences now offers the legally problematic treatment at a Cayman Island facility.

Many stem cell cosmetics reside in a legal gray area. Unlike drugs and "biologics" made from living cells and tissues, cosmetics do not require premarket approval from the FDA. But stem cell cosmetics often satisfy the FDA's definitions for both cosmetics and drugs. In September 2012 the FDA posted a letter on its Web site warning Lancme, a division of L'Oral, that the way it describes its Genifique skin care products qualify the creams and serums as unapproved drugs: they are supposed to "boost the activity of genes," for example, and "improve the condition of stem cells." Other times the difference between needing or not needing FDA approval comes down to linguistic nuancethe difference between claiming that a product does something or appears to do something.

Personal Cell Sciences, in Eatontown, N.J., sells some of the more sophisticated stem cellbased cosmetics: an eye cream, moisturizer and serum infused with chemicals derived from a consumer's own stem cells. According to its website and marketing materials, these products help "make skin more supple and radiant," "reduce the appearance of fine lines and wrinkles around the eyes and lips," "improve cellular renewal" and "stimulate cell turnover for renewed texture and tone." In exchange for $3,000, Personal Cell Sciences will arrange for a participating physician to vacuum about 60 cubic centimeters (one quarter cup) of a customer's fat from beneath his or her skin and ship it on ice to American CryoStem Corp. in Red Bank, N.J., where laboratory technicians isolate and grow the customer's mesenchymal stem cells to around 30 million strong. Half these cells are frozen for storage; from the other half, technicians harvest hundreds of different kinds of exuded growth factors and cytokinesmolecules that help heal damaged cells and encourage cells to divide, among other functions. These molecules are mixed with many other ingredientsincluding green tea extract, caffeine and vitaminsto create the company's various "U Autologous" skin care products, which are then sold back to the consumer for between $400 and $800. When the customer wants a refill, technicians thaw some of the frozen cells, collect more cytokines and produce new bottles of cream.

In an unpublished safety trial sponsored by Personal Cell Sciences, Frederic Stern of the Stern Center for Aesthetic Surgery in Bellevue, Wash., and his colleagues monitored 19 patients for eight weeks as they used the U Autologous products on the left sides of their faces. A computer program meant to objectively analyze photos of the volunteers' faces measured an average of 25.6 percent reduction in the volume of wrinkles on the treated side of the face. Analysis of tissue biopsies revealed increased levels of the protein elastin, which helps keep skin taut, and no signs of unusual or cancerous cell growth.

Only skin deep? Supposedly, the primary active ingredients in the U Autologous skin care products are the hundreds of different kinds of cytokines they contain. Cytokines are a large and diverse family of proteins that cells release to communicate with and influence one another. Cytokines can stimulate cell division or halt it; they can suppress the immune system or provoke it; they can also change a cell's shape, modulate its metabolism and force it to migrate from one location to another like a cowboy corralling cattle. Researchers have only named and characterized some of the many cytokines that stem cells secrete. Some of these molecules certainly help repair damaged cells and promote cell survival. Others seem to be involved in the development of tumors. In fact, some recent evidence suggests that the cytokines released by mesenchymal stem cells can trigger tumors by accelerating the growth of dormant cancer cells. Personal Cell Sciences does not pick and choose among the cytokines exuded by its customers' stem cellsinstead, it dumps them all into its skin care products.

Based on the available evidence so far, topical creams containing cytokines from stem cells pose far less risk of cancer than living stem cells injected beneath the skin. But scientists do not yet know enough about stem cell cytokines to reliably predict everything they will do when rubbed into the skin; they could interact with healthy skin cells in a completely unexpected way, just as the unintended interplay between calcium hydroxylapatite and stem cells produced bones in the Los Angeles woman's eye. Stern acknowledges that unusual tissue growth is a concern for any treatment based on stem cells and the chemicals they release. "Down the line, we want to continue watching that," he says. Unlike many other clinics, he and his colleagues have been keeping tabs on their patients through regular follow-ups. John Arnone, CEO of American CryoStem and founder of Personal Cell Sciences, says the fact that U Autologous skin care products contain such a diversity of cytokines does not bother him: "I've seen worse things out there. I've been putting this formulation for almost a year on myself prior to the study. I'm the best guinea pig here."

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In the Flesh: The Embedded Dangers of Untested Stem Cell Cosmetics

With millions of people in aggregate suffering from debilitating disease, reduced mobility, or relentless pain associated with various conditions, stem cell medicine is available now through WISE Surgical Solutions LLC by direct flight from some major cities to our Joint Commission International Accredited Johns Hopkins affiliated Punta Pacifica Hospital in Panama.

New York (PRWEB) December 06, 2012

Cathy Nenninger, Chief Executive Officer of WISE Surgical Solutions LLC, shared why this offering is important. When I ran wound centers up and down the east coast, I used to get calls from patients and family members desperate for treatments to help alleviate severe symptoms of ailments such as these. It was heartbreaking that we were not able to provide any type of help or hope to these patients. Granted, while the response and success of stem cell treatment in patients varies greatly and by disease, patients who are in extreme discomfort or experiencing reduced function or quality of life deserve to know that they have options available to them.

A significant element of PROJECT HOPE, continues Ms. Nenninger, is the opportunity for community funding of the treatment. Often, families and communities want to help someone by making donations that will collectively fund a surgery or procedure which in itself can add another chore to the already stressed world of a Care Captain (person seeking help for another); Our goal is to make the process easy. For more information on Project Hope, call (631) 942-6040 or for a quote for service, fill out a medical history form available at http://www.WISESurgicalSolutions.com.

WISE Surgical Solutions LLC is based out of New York and caters to companies and patients seeking quality healthcare at an affordable price inclusive of travel. Offerings include medical, dental and surgical procedures of most types, in-vitro fertilization (IVF) and stem cell medicine. Community & group funding as well as financing options are available for patients. Media relations inquiries can be directed to (631) 909-8538 or emailed to surgsolutions(at)optimum(dot)net.

Cathy M. Nenninger, MBA Wise Surgical Solutions LLC (631) 942-6040 Email Information

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WISE Surgical Solutions LLC Announces Project Hope: Helping People with Debilitating Conditions Including Arthritis ...

Jill Helms, "Forever Young: The New Frontier of Stem Cell Medicine"
The good part about getting older is that we gain some wisdom and patience. The bad part is that our bodies start to wear out. But what if we could revitalize our damaged bits back to a healthy state? Come hear what the field of Regenerative Medicine is striving to achieve, and learn how it all begins with the stem cell. Jill Helms is a professor in Plastic and Reconstructive Surgery in the department of surgery at Stanford University #39;s School of Medicine. This Classes Without Quizzes lecture was filmed on location at Stanford Reunion Homecoming 2012 by the Stanford Alumni Association.From:StanfordAlumniViews:11 0ratingsTime:54:05More inEducation

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Jill Helms, "Forever Young: The New Frontier of Stem Cell Medicine" - Video

PROSTATE CANCER and stem cells.wmv
ramirezdelrio.com Business entrepreneur Larry Howard #39;s 77 year old father was in deep trouble. He had been diagnosed with metastatic prostate cancer by his doctors at Kaiser Permanente. Their treatments had failed to check it and it was spreading. As-a-result the elder Howard had lost a great deal of weight and was running out of time. Larry had heard that a team of doctors in Mexico was using umbilical cord stem cells that had been genetically modified to fight cancer. One of the chief medical consultants to this program, in fact, was actually a friend of Larry #39;s; namely, pioneering physician and stem cell medicine expert David Steenblock. Larry took his father to see Dr. Steenblock, who sent them both to Mexico. The senior Mr. Howard was infused with the genetically engineered stem cells and wound up in total remission within 3 month #39;s time. He went on to regain all the weight he had lost previously and soon felt so good that he resumed socializing and dating. In this very short video segment Larry Howard shares how his father went from gravely ill to free of any detectable cancer.From:btancredi1Views:153 0ratingsTime:01:10More inScience Technology

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PROSTATE CANCER and stem cells.wmv - Video

Stem Cell Update from Panama 3 Years Later
I had my first stem cell treatment for Multiple Sclerosis in November 2008. After much research and education, I decided to leave the US and go to Cell Medicine in Costa Rica at the time. 3 years later the clinic has grown and consolidated their lab and facilities to Panama City. The treatment wasn #39;t a cure, but it worked amazingly well for me and gave me a second chance at life. My MS is progressive and I will continue to turn to stem cells for ongoing treatment of my disease. Hopefully one day very soon with continuing discussions with Gov. Rick Perry and others, we will see stem cell treatments more widely available in the United States. iLoveMyNewStemCells!From:Holly HuberViews:1636 12ratingsTime:05:28More inPeople Blogs

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Stem Cell Update from Panama 3 Years Later - Video

RGO Walking
T-6 Asia A Complete Injury. March 4 2011 is the date of my injury. I have had 2 stem cell treatments at Cell Medicine Institute, Panama City, Panama.From:TheBncfilmsViews:853 2ratingsTime:02:41More inEntertainment

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RGO Walking - Video

GeneCell International on Miami Moms
GeneCell International is one of the leaders in the field of stem cell banking. We operate a laboratory that focuses on processing and cryopreserving of stem cells derived from umbilical cord blood, dental pulp, adipose tissue, other tissues, and cells that can be cryogenically preserved. Our purpose is to provide families with the highest quality stem cell products and services and the best customer service, unparalleled scientific excellence and innovative leadership in the areas of stem cell collection, processing and cryopreservation. We are constantly updating our expertise in these disciplines so that individuals and their families can count on every available therapeutic option should a debilitating disease manifest itself. Our goal is to assist individuals around the world make the most of the advances in stem cell medicine.From:genecellintlViews:153 1ratingsTime:00:31More inEducation

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GeneCell International on Miami Moms - Video

Walk
Some video of me doing water therapy at Lawrence County physical therapy Institute in New Castle Pennsylvania. I also do gait training at Harmerville rehab center. My name is Chris Niles. I #39;m a T6 Asia A complete spinal cord injury. I was injured March 4, 2011. I have had two treatments of adult stem cell therapy at Cell Medicine, located in Panama City, Panama. I have made significant gains since participating in stem cell therapy. Improvements with body temperature regulation, blood pressure, lower back muscle regeneration, nerve pain reduction. I Have sensory sensation down to about my T10 in my back. I am looking to go for my third treatment of adult stem cells in 2012.From:Chris NilesViews:542 2ratingsTime:04:27More inPeople Blogs

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Walk - Video

Cord Blood Registry Helps Families Use Stem Cells
Learn more at http://www.cordblood.com CBR #39;s team of dedicated professionals is prepared to guide you through every step of the banking process and beyond. Meet Sherry, CBR #39;s transplant coordinator. As Sherry says, her employer is CBR, but she works for the families who need newborn stem cell medicine. She is the voice parents hear over the phone when they need to use their stored cord blood stem cells. Sherry #39;s dedication and passion to deliver exceptional customer service to clients is one example of the many people at Cord Blood Registry who are committed to helping families live longer, healthier lives.From:cordbloodregistryViews:250 7ratingsTime:01:25More inScience Technology

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Cord Blood Registry Helps Families Use Stem Cells - Video

Cord Blood Registry #39;s Leading Science and Research Team
Learn more about cord blood stem cells here http://www.cordblood.com Cord Blood Registry #39;s Scientific and Medical Affairs team, led by Heather Brown Vice President of Scientific and Medical Affairs, is dedicated to helping understand, communicate and advance stem cell medicine. Her team #39;s focus is on helping find new uses for cord blood, including supporting research that is looking for treatments for conditions that have no treatment today. Our company was founded on the belief that saving newborn stem cells can change the future of medicine. Whether it #39;s providing newborn stem cell banking at no cost to a family with a medical need or partnering with world-class researchers for first-of-their-kind clinical trials, we are committed to advancing stem cell medicine and finding new cures.From:cordbloodregistryViews:202 7ratingsTime:02:05More inEntertainment

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Cord Blood Registry's Leading Science and Research Team - Video

Doctor Reviews: Cord Blood Banking and Rapidly Changing Medicine
Learn more about cord blood banking here: http://www.cordblood.com Meet Dr. Michael Chez, Director of Pediatric Neurology and Epilepsy at Sutter Neuroscience Institute in Sacramento, Calif. Dr. Chez has worked first-hand with patients who have undergone cord blood stem cell infusions as potential treatment for conditions like cerebral palsy. "I think we #39;re at the dawn of a very big leap in science with stem cell medicine," he says. According to Dr. Chez, recommending cord blood banking has become fairly standard in prenatal counseling. It #39;s also becoming normal to ask parents if they #39;ve banked when exploring potential treatment options for diseases and disorders that may be treated with cord blood. "Any friend of the family who asks me, I suggest they bank their baby #39;s cord blood," Dr. Chez adds. Cord blood has been successfully used for more than 20 years to treat many serious diseases like certain cancers and blood, immune, and metabolic disorders. Today, clinical trials are investigating new therapies using a child #39;s own cord blood stem cells for conditions that currently have no treatment, like hearing loss, traumatic brain injury, cerebral palsy, and juvenile diabetes. Several of these clinical trials only use stem cells from CBR as a way of ensuring consistent quality, offering CBR clients exclusive access to groundbreaking medicine. You can learn more about CBR #39;s role in advancing stem cell research through our Center for Regenerative Medicine, cordbloodregistry.com Use ...From:cordbloodregistryViews:667 8ratingsTime:01:44More inScience Technology

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Doctor Reviews: Cord Blood Banking and Rapidly Changing Medicine - Video