Archive for the ‘Gene Therapy Research’ Category

Lot 152 Warner Beef Genetics

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Just the Info: Biology #flipclass Mendelian Genetics #bioHWHL
Our #flipclass introduction to Mendelian Genetics. Link for worksheet: https://www.dropbox.com/s/1jwvw1zafkd9o6f/01%20Autosomal%20Practice.pdf.

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Just the Info: Biology #flipclass Mendelian Genetics #bioHWHL - Video

Lot 154 Warner Beef Genetics

By: Chris Mitchell

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Lot 153 Warner Beef Genetics

By: Chris Mitchell

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Lot 153 Warner Beef Genetics - Video

Schizophrenia has long been known to be highly heritable and is present in approximately 1% of the population. Researchers have been following two paths in their pursuit of identifying schizophrenia risk genes.

Initially, they studied common gene variants that, individually, only increase the risk for schizophrenia by a few percent, perhaps increasing the likelihood of developing schizophrenia from a 10 out of a 1000 chance to an 11 or 12 out of a 1000 chance.

More recently, research has identified gene variants that are rare in the population but, when present, more substantially increase the risk for developing schizophrenia. For example, in the current issue of Biological Psychiatry, a large collaborating group of international scientists, led by Dr. Jennifer Mulle, an Assistant Professor at Emory, report a 1.4 megabase duplication on chromosome 7 (7q11.23) that increases the risk for schizophrenia over 10 times, i.e., to 100 out of a 1000 chance (10%).

"We also found it interesting that three different disorders (schizophrenia, autism, and intellectual development) that strike at different times and present in different ways, have genetic links to this same region on chromosome 7," commented Mulle. "Our findings support the notion of a neuro-developmental link between these disorders."

In this same issue, Dr. George Kirov at Cardiff University and colleagues scanned the genome for copy number gene variants, i.e., where abnormal numbers of gene copies exist. They studied 70 of these variants, all previously implicated in schizophrenia and/or early-onset developmental disorders, such as developmental delay, intellectual deficit and autism spectrum disorders (DD/ID/ASD). They then compared the risk for carriers of these variants to develop one or more of these disorders, i.e. their genetic penetrance.

"The result might be unexpected for many: the penetrance for schizophrenia is several times lower than for the group of DD/ID/ASD. The total penetrance for any of these disorders is quite high, ranging from 10% for duplications at 16p13.11 to nearly 100% for the velocardiofacial syndrome region on chromosome 22. These findings will have implications for genetic counselling of carriers," said Kirov.

"It seems that we are at a critical point in the genetics of schizophrenia -- the identification of rare gene variants that substantially increase the risk for schizophrenia," said Dr. John Krystal, Editor of Biological Psychiatry. "However, we have a very limited understanding of how these genes alter brain development to produce schizophrenia and other disorders. This knowledge would seem to hold clues about mechanisms of prevention and treatment."

In addition, scientists do not yet understand why the genetics of schizophrenia is not tightly aligned with the symptoms of schizophrenia. In other words, gene variants that increase the risk for schizophrenia increase the risk for other disorders, such as developmental delay, autism, and bipolar disorder.

"The failure of our genome to follow DSM-V is not simply a shortcoming of our diagnostic manual, rather it is yet another reminder that there are fundamental aspects of the biology of psychiatric disorders that we do not understand," added Krystal.

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Schizophrenia: Gathering clues to rare gene variants contributing to disease

9:10 How To Survive Armageddon, Peter Kling 20Feb2014
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By: Vincent Eastwood

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5:10 How To Survive Armageddon, Peter Kling 20Feb2014
If you #39;re reading this at http://www.guerillamedia.co.nz click "Original Article" on the bottom right for the video. PLEASE SUBSCRIBE AND GIVE A THUMBS UP Wa...

By: Vincent Eastwood

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PUBLIC RELEASE DATE:

21-Feb-2014

Contact: Vicki Cohn vcohn@liebertpub.com 914-740-2156 Mary Ann Liebert, Inc./Genetic Engineering News

New Rochelle, NY, February 21, 2014Even small increases in blood sugar caused by a diet high in carbohydrates can be detrimental to brain health. Recent reports in medical literature link carbohydrate calorie-rich diets to a greater risk for brain shrinkage, dementia and Alzheimer's disease, impaired cognition, and other disorders. David Perlmutter, MD, best-selling author of Grain Brain, explores this important topic in a provocative interview in Alternative and Complementary Therapies from Mary Ann Liebert, Inc., publishers. The article is available free on the Alternative and Complementary Therapies website.

Dr. Perlmutter, a board-certified neurologist and fellow of the American College of Nutrition, has just been appointed Editor-in-Chief of a new peer-reviewed journal, Brain and Gut, that will debut in summer 2014. The journal will publish leading-edge research dedicated to exploring a whole systems approach to health and disease from the intimate relationship between the brain and the digestive systems.

In the interview "Rethinking Dietary Approaches for Brain Health," Dr. Perlmutter says, "We live with this notion that a calorie is a calorie, but at least in terms of brain health, and I believe for the rest of the body as well, there are very big differences between our sources of calories in terms of the impact on our health. Carbohydrate calories, which elevate blood glucose, are dramatically more detrimental to human physiology, and specifically to human health, than are calories derived from healthful sources of fat."

Dr. Perlmutter will explore how brain health and cognitive function are linked to nutrition in his presentation, "The Care and Feeding of Your Brain," to be delivered at the 2014 Integrative Healthcare Symposium taking place now in New York City.

###

About the Journal

Alternative and Complementary Therapies is a bimonthly journal that publishes original articles, reviews, and commentaries evaluating alternative therapies and how they can be integrated into clinical practice. Topics include botanical medicine, vitamins and supplements, nutrition and diet, mind-body medicine, acupuncture and traditional Chinese medicine, Ayurveda, indigenous medicine systems, homeopathy, naturopathy, yoga and meditation, manual therapies, energy medicine, and spirituality and health. Tables of content and a sample issue may be viewed on the Alternative and Complementary Therapies website.

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Does a diet high in carbohydrates increase your risk of dementia?

PUBLIC RELEASE DATE:

21-Feb-2014

Contact: Sophie Mohin smohin@liebertpub.com 914-740-2100 x2254 Mary Ann Liebert, Inc./Genetic Engineering News

New Rochelle, NY, February 20, 2014A new era of manufacturing is upon us. Recent developments in 3D printing and additive manufacturing technologies are set to usher in the next generation of industrial competitiveness. To address the rapid advances and potential of this groundbreaking new technology, Mary Ann Liebert, Inc., publishers has released an exclusive preview issue of our new peer-reviewed journal 3D Printing and Additive Manufacturing (3DP).

Editor-in-Chief Dr. Hod Lipson, Director of Cornell University's Creative Machines Lab at the Sibley School of Mechanical and Aerospace Engineering, and his expert Editorial Board invite you to view this exclusive preview issue. The Journal will explore emerging challenges and opportunities in additive manufacturing, ranging from new developments of processes and materials, to novel applications in new areas, such as health, medicine, and bio-printing.

To maximize the global impact of this important forum, the articles will be translated into Mandarin Chinese and appear alongside the English version.

"This powerful new journal provides a much-needed multidisciplinary forum on the rapidly evolving technologies of 3D printing engineering and additive manufacturing on a global scale," says Dr. Lipson. "3DP provides a much-needed professional forum for professionals interested in 3D printing across diverse fields, to work towards establishing the next industrial revolution. This journal provides biologists, engineers, materials specialists, and computer scientists a common meeting place."

3DP also addresses the important questions surrounding this powerful and growing field, including issues in policy and law, intellectual property, data standards, safety and liability, environmental impact, social, economic, and humanitarian implications, and emerging business models at the industrial and consumer scales.

###

Contact: Sophie Mohin, Mary Ann Liebert, Inc., (914) 740-2100, smohin@liebertpub.com

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3-D Printing and Additive Manufacturing: Preview issue of groundbreaking peer-reviewed journal now available

Lot 19 Warner Beef Genetics

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Lot 83 Warner Beef Genetics

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Lot 89 Warner Beef Genetics

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Wham City Lecture Series: KEVIN BLACKISTONE on "Genetics", (Part 1)
Shot by Tom Kessler.

By: Thomas Kessler

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Wham City Lecture Series: KEVIN BLACKISTONE on "Genetics", (Part 1) - Video

Lot 81 Warner Beef Genetics

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Lot 88 Warner Beef Genetics

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Wham City Lecture Series: KEVIN BLACKISTONE on "Genetics", (Part 2)
Shot by Tom Kessler.

By: Thomas Kessler

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Wham City Lecture Series: KEVIN BLACKISTONE on "Genetics", (Part 2) - Video

PUBLIC RELEASE DATE:

21-Feb-2014

Contact: Peter Hull phull@clemson.edu 843-209-8341 Clemson University

GREENWOOD, S.C. A new partnership will establish formal collaboration among genetic researchers and Clemson University faculty at the Greenwood Genetic Center and Self Regional Healthcare, expanding an already successful working relationship.

Self Regional Healthcare will support the Clemson University Center for Human Genetics with a gift of $5.6 million over three years. The gift consists of an initial contribution of $2 million for the center's facilities and a subsequent contribution of $3.6 million to support research in genetics and human diagnostics at the facility located on the Greenwood Genetic Center campus.

"Today's announcement will create a new pipeline for genetic research," said John Pillman, chairman of the Self Regional board of trustees. "The collaboration of these three partners will ultimately connect genetic therapeutics research to patients."

Jim Pfeiffer, president and chief executive officer of Self Regional, said the partnership will accelerate the rate of innovation in genetic medicine. "This is what I like to call a win-win-win scenario," said Pfeiffer.

Steve Skinner, director of the Greenwood Genetic Center, said such collaborations are crucial to turning research advances into clinically available therapies for patients, not only in Greenwood and across South Carolina, but globally.

"This collaboration is a major step forward for patients as we combine the resources and strengths of each institution: Self's commitment to patient care, Clemson's expertise in basic scientific research and our experience with genetic disorders and treatment," Skinner said.

Self Regional and the Genetic Center have had an affiliation agreement since 1975 with the Genetic Center's clinical faculty serving as the Department of Medical Genetics for Self Regional.

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Self Regional Healthcare, Clemson, Genetic Center create national genetics research hub

Klaxton Industries - Gene Therapy
A Company that I wish was Real.

By: eglcomedy

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Laminine Testimonial - Stroke
Laminine is availabe in the Philippines!!! "The Closest Alternative To Stem Cell Therapy..." "The miracle formula from a 9-day-old fertilized hen eggs" For M...

By: Julfran Ytang

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Laminine Testimonial - Stroke - Video

Freeport, The Bahamas (PRWEB) February 21, 2014

Okyanos Heart Institute, whose mission it is to bring a new standard of care and a better quality of life to patients with coronary artery disease using adult stem cell therapy, announces CEO Matt Feshbach will present at the STEMSO Conference. He will join a panel to discuss the opportunities available through the new stem cell research and Therapy Act. The conference will be held at the Grand Lucayan Resort in Freeport, Grand Bahamas, February 19-22, 2014. The panel discussion will be Friday, February 21 from 8:45 9:45 a.m.

The conference, titled Bridging the Gap: Research to Point of Care, brings together medical scientists, clinicians, regulatory experts, and investors to discuss progress in the field of research and clinical protocols and the process of taking promising therapies to fight chronic disease to market in a responsible manner.

Friday opening remarks will be delivered by Ian Rolle, President of Grand Bahama Port Authority from 8:30 a.m. to 8:45 a.m. followed by the panel presentation until 9:45 a.m. which, in addition to Rolle will include Feshbach, Mitchell Fuerst, Esq., managing partner, Fuerst, Ittleman, David and Joseph. The panel will be moderated by Arthur K. Parris, Jr. of Parris Whittaker.

"With the passing of the Bahamas Stem Cell Research and Therapy Act, which requires high standards of patient safety and care, we believe the Bahamas is an ideal location to bring internationally-approved, adult stem cell technology to patients with unmet medical needs such as chronic coronary artery disease (CAD), says Feshbach. I am pleased to discuss the opportunities available in the Bahamas with investors, doctors and other stakeholders interested in making the Bahamas a world-class destination for adult stem cell therapy."

The STEMSO 2014 Conference in Freeport, Grand Bahama poses a unique opportunity for medical organizations which focus on adult stem cell-based medical treatments, states Douglas Hammond, president of STEMSO. This conference will provide companies looking to expand their research or clinical practices to offshore locations many good reasons to choose the Bahamas. Those attending will be able to network and view the most advanced research and clinical protocols utilizing autologous and allogeneic stem cells in the world today.

The complete agenda can be found on the organizations website at http://www.stemso.org. Other speakers include stem cell researchers, scientists and practitioners from around the world with leading discoveries in the field, and investors in the healthcare space.

Registration is open for attending and exhibiting on STEMSOs website.

ABOUT OKYANOS HEART INSTITUTE: (Oh key AH nos) Based in Freeport, The Bahamas, Okyanos Heart Institutes mission is to bring a new standard of care and a better quality of life to patients with coronary artery disease using cardiac stem cell therapy. Okyanos adheres to U.S. surgical center standards and is led by Chief Medical Officer Howard T. Walpole Jr., M.D., M.B.A., F.A.C.C., F.S.C.A.I. Okyanos Treatment utilizes a unique blend of stem and regenerative cells derived from ones own adipose (fat) tissue. The cells, when placed into the heart via a minimally-invasive procedure, can stimulate the growth of new blood vessels, a process known as angiogenesis. Angiogenesis facilitates blood flow in the heart, which supports intake and use of oxygen (as demonstrated in rigorous clinical trials such as the PRECISE trial). The literary name Okyanos, the Greek god of rivers, symbolizes restoration of blood flow. For more information, go to http://www.okyanos.com/.

NEW MEDIA CONTENT: Okyanos LinkedIn Page: http://www.linkedin.com/company/okyanos-heart-institute Okyanos Facebook Page: https://www.facebook.com/OKYANOS Okyanos Twitter Page: https://twitter.com/#!/OkyanosHeart Okyanos Google+ Page: https://plus.google.com/+Okyanos/posts Okyanos You Tube Physician Channel: http://www.youtube.com/user/okyanosforphysicians

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Okyanos Heart Institute CEO Matt Feshbach to Speak on Panel at International Stem Cell Society Global Conference

PUBLIC RELEASE DATE:

20-Feb-2014

Contact: Rhiannon Bugno Biol.Psych@utsouthwestern.edu 214-648-0880 Elsevier

Philadelphia, PA, February 20, 2014 Schizophrenia has long been known to be highly heritable and is present in approximately 1% of the population. Researchers have been following two paths in their pursuit of identifying schizophrenia risk genes.

Initially, they studied common gene variants that, individually, only increase the risk for schizophrenia by a few percent, perhaps increasing the likelihood of developing schizophrenia from a 10 out of a 1000 chance to an 11 or 12 out of a 1000 chance.

More recently, research has identified gene variants that are rare in the population but, when present, more substantially increase the risk for developing schizophrenia. For example, in the current issue of Biological Psychiatry, a large collaborating group of international scientists, led by Dr. Jennifer Mulle, an Assistant Professor at Emory, report a 1.4 megabase duplication on chromosome 7 (7q11.23) that increases the risk for schizophrenia over 10 times, i.e., to 100 out of a 1000 chance (10%).

"We also found it interesting that three different disorders (schizophrenia, autism, and intellectual development) that strike at different times and present in different ways, have genetic links to this same region on chromosome 7," commented Mulle. "Our findings support the notion of a neuro-developmental link between these disorders."

In this same issue, Dr. George Kirov at Cardiff University and colleagues scanned the genome for copy number gene variants, i.e., where abnormal numbers of gene copies exist. They studied 70 of these variants, all previously implicated in schizophrenia and/or early-onset developmental disorders, such as developmental delay, intellectual deficit and autism spectrum disorders (DD/ID/ASD). They then compared the risk for carriers of these variants to develop one or more of these disorders, i.e. their genetic penetrance.

"The result might be unexpected for many: the penetrance for schizophrenia is several times lower than for the group of DD/ID/ASD. The total penetrance for any of these disorders is quite high, ranging from 10% for duplications at 16p13.11 to nearly 100% for the velocardiofacial syndrome region on chromosome 22. These findings will have implications for genetic counselling of carriers," said Kirov.

"It seems that we are at a critical point in the genetics of schizophrenia the identification of rare gene variants that substantially increase the risk for schizophrenia," said Dr. John Krystal, Editor of Biological Psychiatry. "However, we have a very limited understanding of how these genes alter brain development to produce schizophrenia and other disorders. This knowledge would seem to hold clues about mechanisms of prevention and treatment."

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Gathering the clues to rare gene variants contributing to schizophrenia

PUBLIC RELEASE DATE:

20-Feb-2014

Contact: Henry French henry.french@icr.ac.uk 020-715-35380 Institute of Cancer Research

Screening men with a family history of prostate cancer for a range of gene mutations can identify those who are at high risk of aggressive forms of the disease and in need of lifelong monitoring, a new study has shown.

Scientists at The Institute of Cancer Research, London, found screening of men who had multiple relatives with prostate cancer was able to pick up 14 mutations in known cancer genes that predicted the development of the disease.

The research was mainly funded by Prostate Cancer UK with additional support from Cancer Research UK, and is published in the British Journal of Cancer today (Friday).

The findings are important because they demonstrate not only that some men have a genetic profile that puts them at higher risk of prostate cancer, but that particular genetic profiles match to a higher risk of advanced, invasive disease. A big challenge facing prostate cancer researchers is to find ways of predicting which men will have life-threatening forms of the disease, to allow treatment to be tailored more effectively.

Scientists at The Institute of Cancer Research (ICR) analysed blood samples from 191 men with prostate cancer at several different UK centres. They were able to use new 'second generation' DNA sequencing technologies to assess mutations in 22 different known cancer genes at once opening up for the first time the prospect of rapid genetic screening for prostate cancer for a wide range of mutations.

The researchers looked at men with a history of three or more cases of prostate cancer in their close family, in order to mirror use of family history as a criterion for existing gene testing programmes in breast cancer.

The researchers found 13 'loss of function' mutations which prevent the genes from producing a properly working protein in eight DNA repair genes. The genes tested for were BRCA1 and BRCA2, which are already routinely tested for in women with a strong family history of breast or ovarian cancer, plus ATM, CHEK2, BRIP1, MUTYH, PALB2 and PMS2.

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Genetic screening can identify men with advanced prostate cancer

PUBLIC RELEASE DATE:

20-Feb-2014

Contact: Vicki Cohn vcohn@liebertpub.com 914-740-2100 Mary Ann Liebert, Inc./Genetic Engineering News

New Rochelle, NY, February 20, 2014Children exhibit a range of responses to traumatic events such as natural disasters, with some suffering acute traumatic reactions that resolve over time and others experiencing long-term symptoms of post-traumatic stress. Identifying factors that may help predict which youths are at greater risk of more serious disorders and which are likely to be more resilient following a traumatic event can help determine the care and services needed, according to an article in Journal of Child and Adolescent Psychopharmacology (JCAP), a peer-reviewed journal from Mary Ann Liebert, Inc., publishers. The article is part of a special issue on pediatric traumatic stress that is available on the JCAP website.

In the article "Resilience and Trajectories of Post-traumatic Stress Among Youth Exposed to Disaster," Carl Weems, PhD and Rebecca Graham, University of New Orleans, LA, compare post-traumatic stress (PTS) symptoms among children exposed to both hurricanes Katrina and Gustav and describe the different risk factors and coping styles associated with resiliency to PTS.

Guest Editors Judith Cohen, MD, Drexel University, Philadelphia, PA, and Michael Scheeringa, MD, Tulane University, New Orleans, LA, emphasize the importance of recognizing the similarities and differences in how children and adults react to traumatic events, and the effect that family dynamics and caregivers can have on treatment strategies and their outcomes in the Journal's Editorial.

In another article, authors Richard Meiser-Stedman, PhD, et al., MRC Cognition & Brain Sciences Unit, Cambridge, U.K., and King's College and King's College Hospital, London, caution against using certain cognitive strategies aimed at blocking trauma-related memories in adults and adolescents in the article entitled "Thought Control Strategies and Rumination in Youth with Acute Stress Disorder and Post-traumatic Stress Disorder Following Single-Event Trauma."

In "Perceived Parenting Change and Child Posttraumatic Stress Following a Natural Disaster," Vanessa Cobham, PhD and Brett McDermott, MD, University of Queensland, Brisbane, Australia, identify a link between specific parenting practices and increased risk for PTS symptoms among the children in a household following a natural disaster.

Harold S. Koplewicz, MD, Editor-in-Chief of JCAP, and President, Child Mind Institute, New York, NY, states that there is a "palpable shift in the profession towards considering even sub-threshold PTS symptoms a worthy target of intervention in kids who have experienced a possible traumatic event, such as natural disaster or violence. Even children who do not meet specific criteria in terms of how they response to trauma may warrant careand this care can be helpful. This work is of particular importance in light of recent school shootings and natural disasters."

###

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Why are some children more resilient to post-traumatic stress?

Lot 4 Warner Beef Genetics

By: Chris Mitchell

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Let #39;s Play The Sims 3 - Perfect Genetics Challenge - Episode 5
VampireClan #VampireClan4Life.

By: vampiregirl101101101

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Let's Play The Sims 3 - Perfect Genetics Challenge - Episode 5 - Video