Archive for the ‘Gene Therapy Research’ Category

Genetics Problem using Google Drawing
CEP 812 Defining Problems of Practice Screencast: Using Google Drawing to solve genetics problems.

By: Allison Birbal

See the article here:
Genetics Problem using Google Drawing - Video

Science 8- Genetics Part 2
Punnett Squares, Mutations and Selective Breeding.

By: Amy Howie

Follow this link:
Science 8- Genetics Part 2 - Video

Frosty Genetics Project

By: Cassie Doubek

See the rest here:
Frosty Genetics Project - Video

[Round 1] TTT + Genetics vs. Teamwork + The Flying Walruses

By: a RandomBob

Read more here:
[Round 1] TTT + Genetics vs. Teamwork + The Flying Walruses - Video

Mendelian Genetics and Punnett Squares
Movie for my high school biology students on basic genetic principles including monohybrid and dihybrid crosses using Punnett Squares and basic Non-Mendelian...

By: Jordana Thompson

View post:
Mendelian Genetics and Punnett Squares - Video

[Round 3] TTT + Genetics vs. Teamwork + The Flying Walruses

By: a RandomBob

See the article here:
[Round 3] TTT + Genetics vs. Teamwork + The Flying Walruses - Video

[Round 2] TTT + Genetics vs. Teamwork + The Flying Walruses

By: a RandomBob

Here is the original post:
[Round 2] TTT + Genetics vs. Teamwork + The Flying Walruses - Video

Savage Genetics - Before The DubStep
A few tunes i found from before i was into listening and making DubStep about 6 years old, so please mind that they sound poor and i haven #39;t done anything ap...

By: SGmusic09

More here:
Savage Genetics - Before The DubStep - Video

Genetics Vocab
description.

By: Cypress Creek Biology

Read more here:
Genetics Vocab - Video

JGH TV - Breakthroughs in Genetics and the Human Genome
Dr. Roderick McInnes, Director of the Lady Davis Institute of the Jewish General Hospital, gives an informational lecture on genetics and the human genome. L...

By: Hpital gnral juif / Jewish General Hospital

View post:
JGH TV - Breakthroughs in Genetics and the Human Genome - Video

Gene therapy, a new weapon against childhood cancers
In its laboratories, Xellbiogene #39;s researchers will focus on genetically modified cells in order to find a treatment for both Acute lymphoblastic leukemia an...

By: Xellbiogene

Go here to see the original:
Gene therapy, a new weapon against childhood cancers - Video

Stem Cell, Eye Stem Cell,Copd Stem Cell
http://yourservice.us/jeunesseglobal.html Stem cell therapy is an intervention strategy that introduces new adult stem cells into damaged tissue in order to ...

By: Agus Saifudin

See more here:
Stem Cell, Eye Stem Cell,Copd Stem Cell - Video

Diabetes Stem Cell, Stem Cell Paraplegic,Stem Cells Regenerate New Finger!
http://yourservice.us/jeunesseglobal.html Stem cell therapy is an intervention strategy that introduces new adult stem cells into damaged tissue in order to ...

By: Agus Saifudin

Read the original:
Diabetes Stem Cell, Stem Cell Paraplegic,Stem Cells Regenerate New Finger! - Video

Anti Stem Cell, Stem Cell Spray, Fetal Stem Cell, Stem Cell Face By Dr. Renato Calabria
http://yourservice.us/jeunesseglobal.html Stem cell therapy is an intervention strategy that introduces new adult stem cells into damaged tissue in order to ...

By: Agus Saifudin

Read the original post:
Anti Stem Cell, Stem Cell Spray, Fetal Stem Cell, Stem Cell Face By Dr. Renato Calabria - Video

Crystalbartonnyc, Anti Aging Routine,Blind Girl Headed To China For Stem Cell Surgery
http://yourservice.us/jeunesseglobal.html Stem cell therapy is an intervention strategy that introduces new adult stem cells into damaged tissue in order to ...

By: Agus Saifudin

Go here to see the original:
Crystalbartonnyc, Anti Aging Routine,Blind Girl Headed To China For Stem Cell Surgery - Video

Eye Stem Cell, Copd Stem Cell, Burt Stem Cell, Sarah Palin on Stem Cell Research
http://yourservice.us/jeunesseglobal.html Stem cell therapy is an intervention strategy that introduces new adult stem cells into damaged tissue in order to ...

By: Agus Saifudin

Originally posted here:
Eye Stem Cell, Copd Stem Cell, Burt Stem Cell, Sarah Palin on Stem Cell Research - Video

Anti Stem Cell | Stem Cell Spray | Fetal Stem Cell | Fat Transfer to Breast
http://yourservice.us/jeunesseglobal.html Stem cell therapy is an intervention strategy that introduces new adult stem cells into damaged tissue in order to ...

By: Agus Saifudin

Read the rest here:
Anti Stem Cell | Stem Cell Spray | Fetal Stem Cell | Fat Transfer to Breast - Video

Goodie Mob - Cell Therapy (Sideeq Remix) (1995) [HQ]
Producer: Sideeq The Beat Freeq Released: 1995 : LaFace Records Official Facebook Page: https://www.facebook.com/BeatJunKie82 --- Original Copyright Owner O...

By: JuNkIEsVirTualCRaTEs

Link:
Goodie Mob - Cell Therapy (Sideeq Remix) (1995) [HQ] - Video

Goodie Mob - Cell Therapy (O.N.P. Production) (1995) [HQ]
Producer: Organized Noize Productions Released: 1995 : LaFace Records Official Facebook Page: https://www.facebook.com/BeatJunKie82 --- Original Copyright O...

By: JuNkIEsVirTualCRaTEs

Link:
Goodie Mob - Cell Therapy (O.N.P. Production) (1995) [HQ] - Video

stem cell therapy treatment for Right Hemiparesis Cerebral Palsy by dr alok sharma, mumbai, india
improvement seen in just 5 days after stem cell therapy treatment for Right Hemiparesis Cerebral Palsy by dr alok sharma, mumbai, india. Stem Cell Therapy do...

By: Neurogen Brain and Spine Institute

See more here:
stem cell therapy treatment for Right Hemiparesis Cerebral Palsy by dr alok sharma, mumbai, india - Video

Khanna and Punzo weigh in on recent clinical trial results By Bryan Goodchild and Ellie Castano January 22, 2014 UMass Medical School Communications

Gene therapy researchers at UMass Medical School focused on degenerative retinal diseases are calling a promising new study out of the University of Oxford the future of gene therapy, after clinical trial participants with a rare eye disease experienced significant improvement in their vision.

This therapy used the AAV [adeno-associated viral] vector. The viral delivery with AAV is extremely safe and I think it is going to be the future of gene therapy, especially in the eye because it is easy to target a multitude of cells, said Claudio Punzo, PhD, assistant professor of ophthalmology, who was not involved in the Oxford study. It holds the promise of treatment for many other retinal diseases.

The small trial targeted a faulty gene in the eye that causes choroideremia, an inherited disease that begins with night blindness and progresses to total blindness. Using AAV vectors to carry healthy versions of the targeted gene to the eye, the treatment produced significantly improved vision in all participants, even those who had just begun to have impaired vision at the start of the trial. The study results were published in The Lancet.

While only a relatively small number of peopleand almost exclusively malesare affected by choroideremia, retinitis pigmentosa is a similar but more common disease of the rods and cones that affects many more.

The incidence of choroideremia is about one in 50,000, whereas retinitis pigmentosa is a relatively more frequent disease that affects one in 3,000 to 4,000, said Hemant Khanna, PhD, assistant professor of ophthalmology, who was also not involved in the Oxford study. This treatment does hold promise for such diseases as retinitis pigmentosa where we can now target photoreceptors. In our lab, we are working on designing treatment strategies for some forms of retinitis pigmentosa.

Read the original post:
UMMS experts: New gene therapy success holds promise for ...

LONDON, Jan 22 (Reuters) - People with schizophrenia have genetic mutations that cluster in specific proteins key to the workings of the brain, according to research that suggests a fresh way to look at the illness and links it to other brain disorders such as autism.

In two research papers published in the Journal Nature, which together made up the largest genetic study of its kind, scientists analysed new or "de novo" gene mutations in people with schizophrenia and found they tend to disrupt sets of proteins which have related functions in the brain.

"De novo" gene mutations are found in affected people but not in their parents - in other words they are not inherited.

As well as identifying how genetic mutations affect brain function, findings also point to an overlap with the causes of other brain disorders such as autism and intellectual disability, the researchers said.

"The fact we've been able to identify a degree of overlap between the underlying causes of schizophrenia and those in autism and intellectual disability suggest...these disorders might share some common mechanisms," said Mick O'Donovan of Britain's Cardiff University, who jointly led the research.

He said the combined finding "tells us that for the first time we have a handle on one of the core brain processes that (are) disrupted in the disorder".

Schizophrenia is one of the most common serious psychiatric illnesses, affecting around 1 in 100 people worldwide. Scientists are not clear exactly what causes it, but believe it could be a combination of a genetic predisposition to the condition as well as environmental factors.

Working with teams from the Icahn School of Medicine at Mount Sinai, New York, the Broad Institute of the Massachusetts Institute of Technology, from Harvard and from Britain's Cambridge University, researchers examined DNA blood samples from 623 schizophrenia patients and their parents.

In a separate study, a second team analysed gene sequences of more than 2,500 people with schizophrenia and around the same number of controls as a comparison.

Their teams found that de novo mutations play a role in triggering schizophrenia, and also that they appear clustered in proteins that are involved in modulating the strength of connections between nerve cells and that play important roles in brain development, learning, memory and cognition.

Go here to see the original:
Discovery of 'De Novo' Gene Mutations Help Scientists ...

Courtesy of Ling Qi

A transmission electron microscopic image shows the sheet-like structure of Endoplasmic Reticulum in normal pancreatic acinar cells (left). Acinar cells of the pancreas produce and secrete digestive enzymes. In the cells without SEL1L genes, these cells appear dilated and fragmented (right). Without the SEL1L gene, the researchers showed that the mice developed exocrine pancreatic insufficiency, where the animals fail to digest and absorb food, become severely malnourished and develop shriveled pancreases.

Much like how a snowplow is needed to clear streets of heavy snow, cells employ a set of genes to clear away misfolded proteins, to prevent them from accumulating and destroying the cell.

For the first time, Cornell researchers have demonstrated how a gene called SEL1L plays a critical role in clearing away misfolded proteins. Complications from misfolded proteins lead to cell death and underlie numerous diseases, including Type 1 diabetes and cystic fibrosis.

SEL1L works within one of several known complexes, known as the endoplasmic reticulum-associated degradation (ERAD), which survey and detect misfolded proteins, grab them and target them for degradation before they accumulate and cause havoc. The endoplasmic reticulum is the cells protein-making machinery, and each ERAD complex is responsible for preventing a subset of these misfolded proteins.

Physiologically, we know almost nothing about the significance of individual ERAD complexes and how they function together in vivo, said Ling Qi, Cornell associate professor of molecular and biochemical nutrition and senior author of a paper published online Jan. 22 in the Proceedings of the National Academy of Sciences. Our study tells us that SEL1L is like the engine of a snowplow; without it, we have no ability to clear the snow in the streets, and cells cannot prevent misfolded proteins from accumulating, said Qi.

Previous research has shown that the SEL1L gene plays a critical role in managing misfolded proteins in yeast, but studying the gene in mammals proved difficult until now, said Qiaoming Long, Cornell assistant professor of animal science and co-senior author on the paper, who has been studying the gene since 2005.

To determine the function of a gene, researchers develop mice without a gene of interest, raise them and look for deficiencies in the mice to determine that genes role. But mice without the SEL1L gene died as embryos. As a result, Qi teamed up with Long to develop mice that were born with the gene, but after birth, the gene could be silenced with injections of a drug called tamoxifen. Without the SEL1L gene, the researchers showed that the mice developed exocrine pancreatic insufficiency, a disease found in humans, dogs and cats, where the animals fail to digest and absorb food, become severely malnourished and develop shriveled pancreases.

When we looked at the cells in the pancreas, we were amazed that the endoplasmic reticulum becomes dilated and fragmented; cells are clearly in the stressed state, said Shengyi Sun, a graduate student and the papers co-first author, along with Guojun Shi, a postdoctoral associate, both of whom work in Qis lab.

In future work, Qi, Long and colleagues will look at the role that SEL1L plays in other tissue types and diseases, such as fat cells in obesity and Type 2 diabetes, intestinal cells in inflammatory bowel disease, and more. Another area of interest will include identifying proteins that this ERAD complex tags and degrades.

The rest is here:
Gene prevents buildup of misfolded cell proteins

People who give blood or other tissues for research should be able to track their use through the scientific process to see the data their activities or samples generate, Harvard University scientists said.

The standard one-way flow of information creates an unequal relationship that blocks participants ability to hold scientists accountable for how the data is used, Harvard genetics researchers George Church and Jeantine Lunshof said in a policy paper written with Barbara Prainsack from Kings College London. The paper will be published tomorrow in the journal Science.

Biobanks hold vast stores of information about individuals genes, tissues, and illnesses, and research subjects should have some right to see where their data is kept and how its used, the authors said. The current system is like a financial bank that wont allow customers to verify that their money is in an account, Lunshof, a visiting fellow in genetics at Harvard Medical School in Boston, said in a telephone interview.

When you donate your data or material to a researcher, its actually quite logical to think youd get an acknowledgment of it and the opportunity to see what you gave them, Lunshof said. But right now it is a one-way transaction, and anything you contribute goes into a black hole.

Church and Lunshof are researchers in the Personal Genome Project, a Harvard-based program that returns the results of full-genome sequencing to individuals. The projects website explains that participants may receive unexpected information about their health or genetic background.

The authors said they werent recommending providing clinical analysis and findings, such as an abnormal heart rhythm or gene mutation, to subjects. Rather, they advocate giving research participants the option to access raw data that their samples generate, such as a gene sequence, with the opportunity to have it interpreted on their own.

Such access would give research subjects the freedom to decide if they want the data, a choice in who analyzes it and would inform their decision-making about participating in studies, Prainsack said in a statement. The same principles would apply in social science research and human behavior studies that dont involve biological samples, Lunshof said.

Human research samples and data are often collected, analyzed, and maintained differently than those that are intended for medical use, said Lainie Ross, a University of Chicago professor of clinical ethics. Giving individuals access to information that may be flawed, inaccurate or out of context incurs the risk that it may lead to harmful decisions, she said.

Theyre confusing clinical care and research, Ross said. To bring data into the clinical setting when it was collected in the research setting is inappropriate.

23andMe Inc. halted sales of health-related data with its DNA tests after the U.S. Food and Drug Administration said that people who dont understand the information might react to it inappropriately. For example, people who discover they have mutations in genes related to breast cancer might get unnecessary medical treatment, the FDA said.

Read more:
Harvard Scientists Say Research Subjects Should See Data

PUBLIC RELEASE DATE:

23-Jan-2014

Contact: Vicki Cohn vcohn@liebertpub.com 914-740-2100 Mary Ann Liebert, Inc./Genetic Engineering News

New Rochelle, January 23, 2014The search for extraterrestrial life extends far beyond Earth's solar system, looking for planets or moons outside the "stellar habitable zone" that may have environments even more favorable to supporting life than here on Earth. These superhabitable worlds have unique characteristics and are ideal targets for extrasolar exploration, as described in a provocative Hypothesis Article in Astrobiology, a peer-reviewed journal from Mary Ann Liebert, Inc., publishers. The article is available free on the Astrobiology website.

In "Superhabitable Worlds" Ren Heller, McMaster University (Hamilton, Ontario, Canada) and John Armstrong, Weber State University (Ogden, UT), propose how tidal heating can create conditions in which life could emerge on an icy or terrestrial planet or moon once thought to be uninhabitable.

"A great place for hydrothermal microorganisms and a volcanic eruption in the weather forecast every morning and evening," says Norman Sleep, Senior Editor for Astrobiology and Professor in the School of Earth Sciences at Stanford University, "a tidally heated planet would be unpleasant though spectacular to visit."

###

About the Journal

Astrobiology, led by Editor-in-Chief Sherry L. Cady, Chief Scientist at the Pacific Northwest National Laboratory, and a prominent international editorial board comprised of esteemed scientists in the field, is the authoritative resource for the most up-to-date information and perspectives on exciting new research findings and discoveries emanating from interplanetary exploration and terrestrial field and laboratory research programs. The Journal is published monthly online with Open Access options and in print, and is the Official Journal of the Astrobiology Society. Complete tables of content and a sample issue may be viewed on the Astrobiology website.

About the Publisher

Read the original:
Looking for a 'superhabitable' world? Try Alpha Centauri B, says Astrobiology Journal