Archive for the ‘Gene Therapy Research’ Category

Perfect Genetics pt 8 Naughty Nate

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Genetics 2nd exam : lecture 2
I created this video with the YouTube Video Editor (http://www.youtube.com/editor)

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Genetics 2nd exam : lecture 9

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Bionanotechnology Applications in Nanotherapeutics, Gene therapy , Immunotherapy
Bionanotechnology combination of biotechnology and nanotechnology. Find its applications in various fields Nanotherapeutics, Gene therapy , Immunotherapy, Ha...

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Bionanotechnology Applications in Nanotherapeutics, Gene therapy , Immunotherapy - Video

Alliance for Cancer Gene Therapy (ACGT): By the Numbers
Alliance for Cancer Gene Therapy (ACGT), the nation #39;s only non-profit dedicated exclusively to gene and cell therapies for treating cancer, has provided over...

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Alliance for Cancer Gene Therapy (ACGT): By the Numbers - Video

For science and cancer treatment, my gene therapy question.
So I #39;ve had plenty of time to sit and think about it, but I #39;m still me, I just have the genes changed. But a small degree, I suppose like a grain of sand in ...

By: bronz3321

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For science and cancer treatment, my gene therapy question. - Video

PUBLIC RELEASE DATE:

16-Dec-2013

Contact: Kathleen Hamilton kathleen.hamilton@nyu.edu 718-260-3792 Polytechnic Institute of New York University

Brooklyn, New York Researchers at the Polytechnic Institute of New York University (NYU-Poly) and the NYU College of Dentistry (NYUCD) have developed a carrier in their lab that is five times more efficient in delivering DNA into cells than today's commercial delivery methodsreagent vectors. This novel complex is a peptide-polymer hybrid, assembled from two separate, less effective vectors that are used to carry DNA into cells.

Results of their study, "Long Term Efficient Gene Delivery Using Polyethylenimine with Modified Tat Peptide," were published in Biomaterials. The findings were the result of a collaborative research project conducted by Dr. Seiichi Yamano at NYUCD and Dr. Jin Montclare at NYU-Poly. The outcome of the study could help researchers better understand gene function and ultimately improve gene therapy.

Non-viral vectors such as those engineered in this study are used for transfectionthe process of introducing foreign genetic material (in this case, DNA called a plasmid) into a cell. The vectors are essentially vehicles that carry the genetic matter into the cell. But transfection is not as easy. Cells are set up to keep things out of the nucleus. Even if the transported plasmid manages to permeate the cellular membrane, the cytoplasm within the cell has safeguards to stop anything from getting into the nucleus.

Traditionally, scientists have engineered viruses to carry out transfection, but viruses are problematic because cells recognize them as foreign and trigger the immune response. Virus transfection is extremely costly and presents numerous difficulties for mass processing. On the other hand, non-viral vectors do not trigger the immune system and are easily manufactured and modified for safe, more effective delivery. Their shortcoming is that they generally are effective only for short periods in transfection, as well as other forms of gene expression.

For this project, Yamano and Montclare paired a modified version of CPP HIV-1 (mTat) with PEI a non-viral vector particularly effective for delivering oligonucleotides. In combining mTat and PEI, they built a new non-viral vector, more effective than mTat or PEI individually. They tested their reagent vector both in vitrogrown in a Petri dishas well as for approximately seven months in a living organism--in vivo.

The vector may be used in the future for targeted gene therapy.

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Researchers engineer a hybrid 5 times more effective in delivering genetic material into cells

stem cell therapy treatment for Quadriplegic Cerebral Palsy by dr alok sharma, mumbai, india short
improvement seen in just 3 months after stem cell therapy treatment for quadriplegic cerebral palsy by dr alok sharma, mumbai, india. Stem Cell Therapy done ...

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stem cell therapy treatment for Quadriplegic Cerebral Palsy by dr alok sharma, mumbai, india short - Video

One year after his combination cell therapy by Dr Harry Adelson for his arthritic knee
Dave discusses the outcome of his combination cell therapy performed by Dr Harry Adelson for his arthritic knee.

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One year after his combination cell therapy by Dr Harry Adelson for his arthritic knee - Video

stem cell therapy treatment for stroke by dr alok sharma, mumbai, india short
improvement seen in just 3 months after stem cell therapy treatment for stroke by dr alok sharma, mumbai, india. Stem Cell Therapy done date 23rd Jul 2013 Af...

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stem cell therapy treatment for stroke by dr alok sharma, mumbai, india short - Video

Biotech company expert in cell therapy products
3P Biopharmaceuticals specialized in the development and manufacture of biologics and cell therapy products, from proof of concept to commercial phase. http:...

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Biotech company expert in cell therapy products - Video

Genetic Engineering Pictures
This is a video of pictures to do with Genetic Engineering.

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Genetic Engineering Pictures - Video

B2.6 Genetic engineering: 11Q2 GM Debate
Learning outcomes: Discuss the advantages and disadvantages of genetic engineering to produce GM organisms.

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Genetic Engineering and Biotechnology | Dr Md Anwarul Azim Akhand | DU
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Alan Watt on The Cloud, Genetic Engineering, Depopulation + Long-Term Conditioning - April 2009
Full interview - http://www.youtube.com/watch?v=WdSj2zaJ-7U Alan Watt #39;s website - http://www.cuttingthroughthematrix.com/ Alan Watt Videos playlist - http://...

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Alan Watt on The Cloud, Genetic Engineering, Depopulation + Long-Term Conditioning - April 2009 - Video

Scientists poking around Ethiopia's fossil-rich badlands say they have discovered the first pieces of an extinct species of horse that was about the size of a small zebra and lived about 4.4 million years ago.

The specimens were found in what is now an arid desert. But at the time this grass-eating horse roamed the planet, the region would have been covered in grasslands and shrubby woods -- rich grounds for grazing.

Fossilized traces of the horse, which was named Eurygnathohippus woldegabrieli, were uncovered in the archaeologically rich sites of Aramis and Gona in Ethiopia's Middle Awash valley. The region is famed for bearing the world's longest and most continuous record of human evolution.

The extinct horse in this study would have actually been alive at the same time the 4.4-million-year-old human ancestor Ardipithecus ramidus, or "Ardi," walked the region.(Beasts of Burden: Amazing Horse Photos)

"Among the many fossils we found are the two ends of the foreleg bone -- the canon -- brilliant white and well preserved in the red-tinted earth," study researcher Scott Simpson, of Case Western Reserve's School of Medicine, said of the horse discovery.

The leg bone bits indicate this horse had longer legs than its ancestors. The shape and size of the leg suggest the beast was a fast runner, a skill that may have helped it flee predators like lions, sabre-tooth cats, Simpson and colleagues say.

"Grasses are like sandpaper," Simpson explained in a statement. "They wear the teeth down and leave a characteristic signature of pits and scratches on the teeth so we can reliably reconstruct their ancient diets."

The horse's teeth show signs of another departure from more ancient species: With crowns worn flatter than the teeth found on its ancestors, it seems this creature became adapted to a life of grazing. An analysis of the enamel on the fossilized teeth provided further evidence that it subsisted on grass like today's zebras, wildebeests and white rhinoceroses, the scientists say.

The animal belonged to a group of ancient horses called Hipparionines, which had three-toed hooves and arose in North America about 16 million years ago before spreading into Eurasia, presumably over a land bridge that once existed between Alaska and Siberia. The researchers say this discovery helps fill in a blank spot in the evolution of horses, before the animals became even better suited for a life in the grasslands, growing taller and developing longer snouts, for example.

"This horse is one piece of a very complex puzzle that has many, many pieces," Simpson said in a statement.

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Fossils of 4.4-Million-Year-Old Horse Found

Viral genetics
#39;Viral genetics #39; is video 4 from week 3 of my 2013 Coursera course #39;How viruses work #39;

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Viral genetics - Video

Genetics and Genomics of Thyroid Neoplasms: Moving Closer towards Personalized Patient Care
December 6, 2013 - The 2013-2014 Genomics in Medicine Lecture Series (Speaker: Electron Kebebew) More: http://www.genome.gov/27553517.

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Genetics and Genomics of Thyroid Neoplasms: Moving Closer towards Personalized Patient Care - Video

Do Genetics Cause An Unfair Advantage Like Steroid Use?
Just an opinion vid, what #39;s your take? My Training Program + Form Check Service - http://www.canditotraininghq.com/products-services/ Facebook Page - https:/...

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Do Genetics Cause An Unfair Advantage Like Steroid Use? - Video

New cancer treatment uses patient #39;s cells to attack disease
An experimental gene therapy treatment has shown promise in the fight against leukemia, and doctors will soon start using the sophisticated immunotherapy in ...

By: CBS Evening News

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Gene therapy using retrovirus vector
This gene therapy video tutorial is to explain the method of gene therapy using retrovirus vector to cure genetic diseases. One example of such retrovirus is...

By: Suman Bhattacharjee

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Gene therapy using retrovirus vector - Video

stem cell therapy treatment for spinal cord injury by dr alok sharma, mumbai, india short
improvement seen in just 4 months after stem cell therapy treatment for spinal cord injury by dr alok sharma, mumbai, india. Stem Cell Therapy done date 2nd ...

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stem cell therapy treatment for spinal cord injury by dr alok sharma, mumbai, india short - Video

By Dalia Dangerfield, Reporter Last Updated: Saturday, December 14, 2013, 8:48 PM TAMPA --

USF researchers believe stem cell therapy can help men and women with mild brain injuries.

This is quite a phenomenal observation, said Dr. Cesar Borlongan, a neuroscientist from USF Health. In our hands, stem cell therapy may offer this hope for the soldiers to prevent the progression of the disease and hopefully we can stop the disease process at the early stage."

In a recent study Borlongan injected adult stem cells in rats with traumatic brain injury. The stem cells served as a bridge, allowing new brain cells to move up to the damaged part of the brain.

That's a new concept, it's like the cells are very smart, said Borlongan.

Over time the adult stem cells helped partially repair the brain damage in rats.

Professor Borlongan believes the same may be true for humans allowing them to slowly get better.

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New study shows stem cell therapy helps brain injuries

At the forefront of medicine, Gene Therapy brings you the latest research into genetic and cell-based technologies to treat disease. It also publishes Progress & Prospects reviews and News and Commentary articles, which highlight the cutting edge of the field.

Volume 20, No 12 December 2013 ISSN: 0969-7128 EISSN: 1476-5462

2012 Impact Factor 4.321* 70/290 Biochemistry & Molecular Biology 22/159 Biotechnology & Applied Microbiology 33/161 Genetics & Heredity 25/121 Medicine, Research & Experimental

Editors: J Glorioso, USA N Lemoine, UK

*2012 Journal Citation Reports Science Edition (Thomson Reuters, 2013)

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Gene Therapy now offers authors the option to publish their articles with immediate open access upon publication. Open access articles will also be deposited on PubMed Central at the time of publication and will be freely available immediately. Find out more from our FAQs page.

Reviews by top researchers in the field. See the recent Progress and Prospects articles.

Essential topics explored in depth in Gene Therapy Special Issues.

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Gene Therapy - Nature

PUBLIC RELEASE DATE:

9-Dec-2013

Contact: Cara Martinez cara.martinez@cshs.org 310-423-7798 Cedars-Sinai Medical Center

LOS ANGELES (Dec. 9, 2013) Researchers in the Women's Cancer Program at Cedars-Sinai's Samuel Oschin Comprehensive Cancer Institute have identified a series of 10 genes that may signify a trifecta of benefits for women diagnosed with ovarian cancer and ultimately reflect improved survival outcomes.

The research, led by Dong-Joo (Ellen) Cheon, PhD, found that the 10-gene biomarker panel may identify the aggressiveness of a patient's disease, help predict survival outcomes and result in novel therapeutic strategies tailored to patients with the most adverse survival outcomes.

When a patient's tumor is identified as having elevated levels of these 10 specific genes, doctors may be able to better predict which treatments would be most effective, said Cheon, whose research was published in Clinical Cancer Research.

That is an important advance because ovarian cancer is the most lethal gynecologic cancer and is often diagnosed in later, more aggressive stages, resulting in poor prognosis and survival. These outcomes differ due to development of tumors that become resistant to chemotherapy. By identifying chemo-resistant tumors and identifying the risk of poor survival outcomes during the diagnostic process, investigators hope to extend lives and improve treatment responses for women with ovarian cancer.

"The ultimate goal is to use the 10-gene biomarker panel to develop a diagnostic kit that will identify patients with the most adverse outcome and provide targeted therapeutic strategies," said Cheon. "Among the biomarkers identified, the gene COL11A1 was shown to be the most abundantly expressed in ovarian cancer progression. But when we blocked expression of COL11A1 in murine cancer cells, tumor growth and spread was significantly reduced."

The 10-gene biomarker panel revealed another promising benefit. The 10 genes associated with the panel all share one common biological process the formation of a collagen matrix around cancerous cells. This thick, collagen-rich matrix can protect cancer cells from the lethal effect of chemotherapy and serve as an incubator for increasingly aggressive cancer cells. Understanding how this collagen-rich environment may contribute to aggressive tumor cell behavior may ultimately lead to more efficient therapies.

"This data, based on the analysis of nearly 800 ovarian cancer patients, suggests that patients who have elevated levels of genes associated with the biomarker panel have shorter survival and more aggressive forms of disease," said Sandra Orsulic, PhD, senior author of this study, director of women's cancer biology in the Women's Cancer Program and associate professor in the Department of Obstetrics and Gynecology. "These findings indicate that even though patients present with the same disease stage at diagnosis, their survival outcomes differ."

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Ovarian cancer discovery deepens knowledge of survival outcomes