Archive for the ‘Gene Therapy Research’ Category

Suzanne Miles logs DNA samples into the Myriad Genetics computer system so they can be tracked during the analysis process.

Scott G Winterton, Deseret News

SALT LAKE CITY The U.S. Supreme Court is expected to announce sometime this month whether it is possible to patent human genes.

The American Civil Liberties Union represented research scientists and health advocates who teamed up in 2009 to challenge patents issued in the 1990s to Myriad Genetics, a Utah-based biotech company, and the University of Utah Research Foundation. Myriad has patented the BRCA1 and BRCA2 genes; mutations indicate a hereditary predisposition to certain breast and ovarian cancers. The Supreme Court heard arguments in April in the case of Association for Molecular Pathology, et al. v. Myriad Genetics Inc.

Before the court

The ACLU briefing notes said that Myriads monopoly on the BRCA genes makes it impossible for women to access other tests or get a second opinion about their results and allows Myriad to charge a high rate for its test over $3,000. Critics said the company, which has vigorously enforced its patents, has blocked development and use of better technologies and driven up costs.

Advocates of the patents and Myriad Genetics said companies must be able to reap financial rewards for investment in genetic research and that isolating genes and other processes amount to invention that can be patented. Myriad spokesman Ron Rogers said the test is covered by all insurance companies and pricing is in line with other molecular diagnostic tests. If someone doesn't have insurance, Myriad provides inexpensive and sometimes free testing, he said.

Theres no question that the tests Myriad developed to find BRCA mutations can be patented. But lower courts have been divided on whether Myriad can claim that isolating and pulling out that gene from the human body is creative enough to patent, since nature cannot be patented. The federal district court tossed the patents. An appeals court disagreed with the lower court, 2-1, and ruled Myriad Genetics made the genes more useful when it isolated segments. That court was unanimous in saying that cDNA, which resulted from removing noncoding material, was patentable.

The choices

The Supreme Court has three options, said Shobita Parthasarathy, associate professor in the Ford School of Public Policy at the University of Michigan.

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Can a human gene be patented? Utah company says yes; Supreme Court poised to decide

Public release date: 10-Jun-2013 [ | E-mail | Share ]

Contact: Vicki Cohn vcohn@liebertpub.com 914-740-2100 x2156 Mary Ann Liebert, Inc./Genetic Engineering News

New Rochelle, NY, June 10, 2013The Genetics Policy Institute (GPI) and Mary Ann Liebert, Inc., publishers have announced that the 2013 World Stem Cell Report will be published as a special supplement to the peer-reviewed journal Stem Cells and Development. Dr. Graham Parker and Bernard Siegel will serve as Co-Editors-in-Chief, joined by Rosario Isasi (McGill University) as Managing Editor.

It was also announced that Mary Ann Liebert, Inc., publishers and Genetic Engineering & Biotechnology News (GEN), a Liebert publication, will become joint platinum media sponsors of the GPI's 2013 World Stem Cell Summit that will take place at the Manchester Grand Hyatt San Diego, December 4 in San Diego, CA.

Bernard Siegel, Executive Director of GPI and Founder and Co-chair of the Summit said, "We are proud to partner with Graham Parker and the skilled editorial team at Stem Cells and Development to publish our annual Report. The Journal's extensive audience, combined with the reach of the community attending and supporting the World Stem Cell Summit, will allow our readership to expand exponentially. We will continue to provide an array of specialized articles offering unique insights of leading policy-makers, regulators, and experts in law, ethics, advocacy, industry, and philanthropy from countries, regions, and states. The Report fills a critical unmet need by providing a global framework for all stakeholders."

Mary Ann Liebert, publisher & CEO of both Stem Cells and Development and GEN stated, "We are delighted to be working with a key thought leader and senior statesman for the field, Bernie Siegel, and his GPI team on this important collaboration. The World Stem Cell Report delivers an orbital and unique viewpoint, with content that is timely, comprehensive, and direct. We are proud to add this important annual publication to our many journals that intersect the world of regenerative medicine."

GEN Editor-in-Chief John Sterling stated, "The World Stem Cell Summit is the critical global meeting, providing the best opportunity for the GEN community to participate in the world of regenerative medicine. Our platinum media sponsorship allows GEN readers, both in print and online, and advertisers to have a front row seat to listen and learn from the top experts on the very dynamic and expertly conceptualized Summit platform."

The Report will be made available to all subscribers of Stem Cells and Development and complimentary to attendees of the World Stem Cell Summit. The Summit program delivers on the "big picture" featuring 170+ prominent scientists, business leaders, regulators, policy-makers, advocates, economic development officers, experts in law and ethics, and visionary gurus who will discuss the latest scientific discoveries, business models, legal and regulatory solutions, and best practices. The Summit is expected to attract attendees from more than 40 nations.

###

About Mary Ann Liebert, Inc., publishers

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World Stem Cell Summit to be presented by Genetics Policy Institute, Mary Ann Liebert, Inc., and Genetic Engineering ...

SEATTLE, June 11, 2013 /PRNewswire/ --Natural Molecular Testing Corporation (Natural Molecular, NMTC), a privately-owned company providing groundbreaking clinical diagnostic molecular testing and services in the medical genomics field, announced today the launch of their laboratory developed comprehensive Personalized Medicine Panel. This cardiac panel, commercialized by Natural Molecular, is comprised of 42 targets and built using Luminex Corporation's (LMNX) xMAP Technology.

(Logo: http://photos.prnewswire.com/prnh/20100104/LUMINEXLOGO)

"Our goal is to bring the latest advancements in medical science and technology to help clinicians do one simple thing: provide the best possible care for their patients," said Beau R. Fessenden, CEO of Natural Molecular. "By converting to Luminex's xMAP technology, we can improve our throughput and workflow efficiency with more comprehensive and highly sensitive assays that set us apart in the marketplace. The flexibility and high throughput of the Luminex platform combined with the ability to add additional biomarkers make the technology unique and best suited to our expanding needs."

Each year more than 2 million Americans are hospitalized due to adverse drug reactions which lead to an estimated 100,000 deaths.1 Molecular testing allows physicians to diagnose genetic abnormalities in patients, providing guidance in selecting optimal medications and doses of medications while minimizing risk for a wide variety of common conditions such as chronic heart disease and pain.

"We are excited to be expanding our relationship with Natural Molecular in the important area of pharmacogenomics," said Patrick Balthrop, president and CEO of Luminex. "It is valuable for a physician to know whether a specific therapeutic compound will be most beneficial for a particular patient. Through the use of genetic testing, driven by the throughput and scalability of our technology and the unique services of NMTC, our two companies are working together to optimize patient outcomes and lower overall health-care costs. We look forward to expanding opportunities with Natural Molecular, a leader in pharmacogenomic testing."

The financial terms of the multi-year collaboration and license agreement were not disclosed.

About Personalized Medicine PanelNatural Molecular's new comprehensive Personalized Medicine Panel features a simple laboratory workflow based on Luminex's flexible xMAP Technology. Multiplexing a comprehensive set of biomarkers together from a single sample offers significant improvements in testing efficiency saving valuable time and increasing throughput. The panel includes the following:

CYP450 2C19 CYP450 2C9 CYP450 2D6 CYP450 3A4 CYP450 3A5 ABCB1 VKORC1 MTHFR Factor II Factor V Leiden

About Natural Molecular Testing Corporation

Natural Molecular Testing Corporation (NMTC) is a privately-owned, high-complexity molecular testing facility. NMTC provides comprehensive genetic testing solutions that improve patient care through the latest breakthroughs in genomic technology.

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Natural Molecular Testing Corporation Launches an Expanded Personalized Medicine Panel Built on Luminex Corporation's ...

World-Wide Premiere Features Collaboration of Science and Medicine That Unlocked Diagnosis

ALISO VIEJO, CA--(Marketwired - Jun 11, 2013) - The world-wide premiere of "The Life We Live" is scheduled to debut on Thursday, June 20 on http://www.TheLifeWeLiveDoc.com. A heart-felt documentary chronicling the Spooner family's struggle, "The Life We Live" shares their battle to fight the rare disorder plaguing their two daughters. As a result of exome sequencing, the Spooners have discovered answers they have long been seeking. With only days until the world-wide premiere, a teaser trailer is currently available here: http://www.thelifewelivedoc.com/teaser.html.

"The Life We Live" shares Cristy and Rick Spooner's 14-year struggle and race against time to find an answer to the illness that affects two of their three daughters. Cali, 14, and Ryann, 4, suffer from the same rare genetic disorder, which severely limits their ability to walk, talk and care for themselves. After years of testing and waiting, the Spooners finally received answers to their 14-year nightmare. Now, they are sharing their story in hopes of shedding light on how exome sequencing has given their daughters hope for a better life.

"We decided to share our story in such a personal way in hopes that we can help other families around the world," said Cristy Spooner. "There was a time when accepting that we may never know what afflicted our daughters was reality, then, coming across cutting-edge testing such as exome sequencing changed our lives. We hope our story can help another family fight their brave battle."

The documentary is a collaboration between three different organizations united by the commonality of researching and fighting rare orphan diseases. With different backgrounds in medical technology, world-renowned research and as the leading rare and genetic disease patient advocacy organization in the world, these organizations all have the same goal -- to help the Spooners find answers they have been waiting for. The relentless efforts of Ambry Genetics, a global leader in genetic services with a focus on clinical diagnostics and genomics, Dr. Virginia Kimonis of the UC Irvine Division of Genetics and Metabolism, and Nicole Boice, founder and president of Global Genes/RARE Project, finally helped unlock a diagnosis.

ABOUT THE DOCUMENTARY: The Spooner family is not alone. Currently, there are more than 7,000 identified rare diseases, which because of their "rarity," results in tens of thousands of undiagnosed individuals annually. Exome sequencing can help the more than 350 million people worldwide affected by a rare disease. "The Life We Live" is a documentary that follows one family's long-fought battle against a rare genetic disorder. For all parties involved, the hope is for the documentary to shed light onto the issue of rare disorders and to help others find answers. To learn more about the Spooners' struggle, exome sequencing or the documentary, please visit http://www.TheLifeWeLiveDoc.com.

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Documentary Showcasing One Family's Struggle and Triumph With a Rare Genetic Disorder

Genetics of corn lab (Dihybrid crosses)
Genetics of corn lab (Dihybrid crosses)

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Genetics of corn lab (Dihybrid crosses) - Video

Genetically Modified Food Genetics GMO #39;s Biochemistry

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Genetically Modified Food

4) Técnica de Inseminción Artificial

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4) Técnica de Inseminción Artificial - Video

Let #39;s Play The Sims 3 - Perfect Genetics Challenge - Episode 16
My Sims 3 Page: http://mypage.thesims3.com/mypage/Llandros2012 My Blog: http://Llandros09.blogspot.com My Facebook: https://www.facebook.com/Llandros09?ref=t...

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Let's Play The Sims 3 - Perfect Genetics Challenge - Episode 16 - Video

Suzanne Miles logs DNA samples into the Myriad Genetics computer system so they can be tracked during the analysis process.

Scott G Winterton, Deseret News

SALT LAKE CITY The U.S. Supreme Court is expected to announce sometime this month whether it is possible to patent human genes.

The American Civil Liberties Union represented research scientists and health advocates who teamed up in 2009 to challenge patents issued in the 1990s to Myriad Genetics, a Utah-based biotech company, and the University of Utah Research Foundation. Myriad has patented the BRCA1 and BRCA2 genes; mutations indicate a hereditary predisposition to certain breast and ovarian cancers. The Supreme Court heard arguments in April in the case of Association for Molecular Pathology, et al. v. Myriad Genetics Inc.

Before the court

The ACLU briefing notes said that Myriads monopoly on the BRCA genes makes it impossible for women to access other tests or get a second opinion about their results and allows Myriad to charge a high rate for its test over $3,000. Critics said the company, which has vigorously enforced its patents, has blocked development and use of better technologies and driven up costs.

Advocates of the patents and Myriad Genetics said companies must be able to reap financial rewards for investment in genetic research and that isolating genes and other processes amount to invention that can be patented. Myriad spokesman Ron Rogers said the test is covered by all insurance companies and pricing is in line with other molecular diagnostic tests. If someone doesn't have insurance, Myriad provides inexpensive and sometimes free testing, he said.

Theres no question that the tests Myriad developed to find BRCA mutations can be patented. But lower courts have been divided on whether Myriad can claim that isolating and pulling out that gene from the human body is creative enough to patent, since nature cannot be patented. The federal district court tossed the patents. An appeals court disagreed with the lower court, 2-1, and ruled Myriad Genetics made the genes more useful when it isolated segments. That court was unanimous in saying that cDNA, which resulted from removing noncoding material, was patentable.

The choices

The Supreme Court has three options, said Shobita Parthasarathy, associate professor in the Ford School of Public Policy at the University of Michigan.

Go here to see the original:
Can a human gene be patented? Myriad Genetics says yes; Supreme Court poised to decide

BOTHELL, Wash.--(BUSINESS WIRE)--

Seattle Genetics, Inc. (SGEN) today announced the initiation of a phase 1/2 clinical trial evaluating ADCETRIS (brentuximab vedotin) in combination with bendamustine for patients with Hodgkin lymphoma (HL) after first relapse. The multi-phase study is divided into two cohorts to determine the recommended dosing level and tolerability of combination use and to assess the complete remission rate associated with ADCETRIS in combination with bendamustine. Seattle Genetics is the leader in the field of antibody-drug conjugates (ADCs) and ADCETRIS is an ADC directed to CD30, a defining marker of classical HL. ADCETRIS is not approved for salvage HL patients who are deemed eligible for autologous stem cell transplant (ASCT).

One of the key goals of our broad ADCETRIS clinical development program is to evaluate its use in earlier lines of HL therapy. This trial will assess the ability of ADCETRIS in combination with bendamustine to induce durable complete remissions in second-line treatment of HL patients prior to transplant, said Clay B. Siegall, Ph.D., President and Chief Executive Officer at Seattle Genetics. In this treatment setting, single-agent bendamustine has been shown to induce a high rate of remissions with limited durability. Data from an investigator-sponsored trial with single-agent ADCETRIS demonstrated encouraging activity and tolerability in this setting. This trial is designed to determine if the combination can result in durable complete remissions, potentially increasing the number of patients eligible to receive a transplant.

This phase 1/2 single-arm, open-label clinical trial will evaluate the efficacy and tolerability of ADCETRIS in combination with bendamustine in HL patients after first relapse. Patients will be eligible to receive up to six cycles of ADCETRIS in combination with bendamustine followed by additional single-agent ADCETRIS for up to a total of 16 cycles. As a part of the trial design, after patients receive ADCETRIS plus bendamustine combination therapy, they have the option to pause therapy to receive an ASCT and then resume treatment with single-agent ADCETRIS as consolidation. Bendamustine is an alkylating agent used in the treatment of chronic lymphocytic leukemias and lymphomas. The primary endpoint of the phase 1 cohort is to determine the recommended dosing level of bendamustine in combination with ADCETRIS as well as the safety and tolerability of the combination. The primary endpoint of the phase 2 cohort is to assess the complete remission rate. Key secondary endpoints include best response, duration of response and progression-free survival. The study is expected to enroll up to 50 patients at multiple centers in the United States.

At the 54th American Society of Hematology (ASH) Annual Meeting and Exposition held December 8-11, 2012 in Atlanta, GA, encouraging data were presented from an abstract titled Brentuximab Vedotin as a First Line Salvage Therapy in Relapsed/Refractory HL (Abstract #3699). The investigator-sponsored trial was conducted to evaluate ADCETRIS as a salvage therapy for HL. Fourteen patients were evaluated for response and safety and all had relapsed or refractory HL after initial therapy with chemotherapy regimens or a combination of chemotherapy with or without consolidative radiation treatment.

Of the 14 evaluable patients, 12 patients (85.7 percent) had an objective response rate, including seven (50 percent) complete remissions and five (35.7 percent) partial remissions. The most common Grade 1 or 2 adverse events were peripheral sensory neuropathy (42.9 percent), acneiform rash (35.7 percent), AST elevation (28.6 percent) and fatigue (28.6 percent). Grade 3 adverse events were rash acneiform (7.1 percent) and urinary tract infection (7.1 percent), and there were no Grade 4 adverse events. The abstract can be found at http://www.hematology.org.

More information about the phase 1/2 trial of ADCETRIS in combination with bendamustine, including enrolling centers, is available by visiting http://www.clinicaltrials.gov.

About ADCETRIS

ADCETRIS (brentuximab vedotin) is an ADC comprising an anti-CD30 monoclonal antibody attached by a protease-cleavable linker to a microtubule disrupting agent, monomethyl auristatin E (MMAE), utilizing Seattle Genetics proprietary technology. The ADC employs a linker system that is designed to be stable in the bloodstream but to release MMAE upon internalization into CD30-expressing tumor cells.

ADCETRIS was granted accelerated approval by the FDA in August 2011 and approval with conditions by Health Canada in February 2013 for two indications: (1) the treatment of patients with HL after failure of autologous stem cell transplant (ASCT) or after failure of at least two prior multi-agent chemotherapy regimens in patients who are not ASCT candidates, and (2) the treatment of patients with sALCL after failure of at least one prior multi-agent chemotherapy regimen. The indications for ADCETRIS are based on response rate. There are no data available demonstrating improvement in patient-reported outcomes or survival with ADCETRIS.

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Seattle Genetics Announces Initiation of Phase 1/2 Trial of ADCETRIS® (Brentuximab Vedotin) in Combination with ...

SEATTLE, WA--(Marketwired - Jun 10, 2013) - Atossa Genetics, Inc. (NASDAQ: ATOS), The Breast Health Company, today announced its support for Are You Dense, Inc., an independent, national breast health advocacy organization dedicated to informing the public about dense breast tissue and its significance for the early detection of breast cancer. Are You Dense, Inc. was founded by Nancy M. Cappello, Ph.D., who was diagnosed with advanced stage breast cancer in February 2004 after receiving "normal" mammography reports for a decade.

Dr. Steven Quay, chairman, CEO & president of Atossa Genetics and inventor of the ForeCYTE Breast Health Test for breast cancer risk assessment, stated, "According to published data, women with dense breasts are at higher risk of breast cancer. In addition, dense breasts make spotting tumors by mammography more difficult, increasing the chances that a tumor will be missed. We believe that the efforts of Are You Dense Advocacy, Inc. to enact legislation requiring that women be notified if they have dense breasts are in the public interest. We support the efforts of Are You Dense Advocacy and encourage the enactment of dense breast notification laws."

Dense breast notification legislation requires that women who are found through mammography to have dense breasts must be notified of this fact. Seven states, including California, Connecticut, Hawaii, Maryland, New York, Texas and Virginia have enacted such legislation. Similar dense breast measures have been introduced or advanced in many other states. At the federal level, the Breast Density and Mammography Reporting Act of 2011 (HR 3102) was introduced in the previous Congress in October 2011 by Representative Rosa DeLauro (D-CT) and Representative Steve Israel (D-NY).

"We know that early detection of breast cancer saves lives," said Kathleen Vielhaber of Bellingham, Washington, whose sister passed away in 2013 at the age of 53 from breast cancer after her advanced cancer was not detected by a mammogram. "Women with dense breasts, such as my sister, may need additional screening with newer methods, such as Atossa's ForeCYTE Breast Health Test, that are not affected by dense breast tissue. That's why I support Are You Dense to help raise awareness of the need for more and better screening of women with dense breasts and to make sure they get information that could save their lives."

Dr. Quay said that Atossa looks forward to working with Vielhaber in Washington State to enact a breast density notification law.

In January 2013, Atossa launched the ForeCYTE Breast Health Test, which analyzes cells from the linings of the milk ducts where approximately 95 percent of breast cancers arise. Atossa believes that its test is advantageous for women with dense breasts since dense breast tissue does not affect the test's ability to collect and analyze cells and assess breast cancer risk.

For additional information on breast cancer risk, including the risks associated with dense breasts, please visit the Breast Cancer Overview page on the American Cancer Society's website.

About Atossa Genetics, Inc.

Atossa Genetics, Inc. (NASDAQ: ATOS), The Breast Health Company, is based in Seattle, WA, and is focused on preventing breast cancer through the commercialization of patented diagnostic medical devices and patented laboratory developed tests (LDT) that can detect precursors to breast cancer up to eight years before mammography, and through research and development that will permit it to commercialize treatments for pre-cancerous lesions. Are You Dense, Inc. is not affiliated with Atossa Genetics.

The National Reference Laboratory for Breast Health (NRLBH), a wholly owned subsidiary of Atossa Genetics, Inc., is a CLIA-certified high-complexity molecular diagnostic laboratory located in Seattle, Washington. The NRLBH provides the patented ForeCYTE Breast Health Test, a risk assessment test for women 18 to 73 years of age akin to the Pap Smear, and the ArgusCYTE Breast Health Test, a blood test for recurrence in breast cancer survivors that provides a "liquid biopsy" for circulating breast cancer cells and a tailored treatment plan for patients and their caregivers.

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Atossa Genetics Supports Are You Dense, Inc. and Its Work to Enact Dense Breast Notification Laws

WALTHAM, Mass.--(BUSINESS WIRE)--

Interleukin Genetics, Inc. (ILIU) today announced the online publication of the research study Patient Stratification for Preventive Dental Care in Journal of Dental Research. The study provides new insights into the prevention of periodontitis (gum disease) and the opportunity for significant advancement in the delivery of personalized, preventive dental care. Periodontitis affects 47 percent of the adult population.

The study explored the influence of three key risk factors for periodontal diseasesmoking, diabetes and geneticson tooth loss given varied frequencies of preventive dental visits that included cleanings. By examining claims data from 5,117 patients without periodontitis throughout a 16 year period and conducting genetic testing, researchers determined that patients with genetic variations of the IL-1 genotype, or one or more other risk factors examined, were at significantly increased risk for tooth loss and therefore require more preventive dental care. The IL-1 genetic variation was the single most prevalent risk factornearly one in three Americans carry this genetic variation. This study demonstrates the important opportunity to provide more effective preventive oral care through the use of risk-based patient assessment that includes genetic testing.

Research was conducted under the direction of Dr. William Giannobile, Najjar endowed Professor of Dentistry and Biomedical Engineering, and Chair of the Department of Periodontics and Oral Medicine at the University of Michigan.

Periodontitis is a bacterially induced chronic inflammatory disease that destroys the bone and gum tissues that support the teeth. It is one of the most common chronic diseases of the body. It causes bleeding and swelling of the gums, loose teeth, bad breath and can ultimately lead to tooth loss. Severe periodontitis has been associated with increased risk for multiple other diseases, including cardiovascular diseases, diabetes and rheumatoid arthritis. One in four Americans over age of 65 have lost all their teeth.

Dentistry has long been a leader in the delivery of preventive healthcare to patients. The findings of this study provide dental clinicians with the opportunity to offer personalized, preventive care that is based on new insights into the importance of genetic risk factors, said Dr. Kenneth Kornman, Chief Executive Officer of Interleukin Genetics, which developed the genetics test used in the study.

Personalized medicine is an important frontier in healthcare driven by the clinical application of genetic and molecular information. Genetic-based risk assessment has long promised to improve prevention and treatment of chronic diseases, said Sir Gordon Duff, Professor Emeritus of Molecular Medicine the University of Sheffield and co-author of the paper. The findings of this study represent perhaps the first broad scale application of genetics to help prevent a disease that is very prevalent, costly and preventable.

Periodontitis initiation and progression is driven by two factors: bacterial plaque that initiates the disease and the bodys inflammatory response to bacteria which, when overly aggressive, causes breakdown of the bone and tissue that support the teeth. This inflammatory response varies greatly within the population and is significantly impacted by individual genetic make-up. Genetic testing can identify patients who have an increased inflammatory response to oral bacteria which significantly increases risk of periodontitis and tooth loss. Smoking and diabetes also contribute significantly to the risk of periodontal disease.

Ultimately, patients should be evaluated by their dentist regularly and receive needed preventive care before any symptoms of periodontal disease appear. This disease can result in disfiguring bone loss around teeth and has been implicated as a risk factor for multiple systemic conditions that benefit from early stage prevention, said periodontist Donald S. Clem, III, D.D.S., Diplomate, American Board of Periodontology, Past President American Academy of Periodontology. Historically, we have lacked the prognostic tools to effectively identify patients at greatest risk for periodontitis. This study underscores the need to adopt a genetic, risk-based approach and gives patients a compelling new reason to visit the dentist for a comprehensive periodontal evaluation. As we see with other chronic diseases, identifying and understanding genetic predisposition to disease is a critical component of long term prevention."

For additional details, the study Patient Stratification for Preventive Dental Care Giannobile et al. 2013 from Journal of Dental Research, can be accessed online.

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Study Published in Journal of Dental Research Demonstrates Value of Genetics in Preventing Periodontal Disease

Character Genetics experience learning

By: CharacterGenetics

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Character Genetics experience learning - Video

Genetics Smart Test 10 , best coaching for NEET
Napellus Edutech #39;s Biology Smart Test Demos.

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Genetics Smart Test 10 , best coaching for NEET - Video

New Zealands top red meat genetics company, Focus Genetics is congratulating the Maori Farmer of the Year, to whom it supplies quality genetics.

Te Awahohonu Forest Trusts Tarawera Station has picked up the 80th Ahuwhenua Trophy Maori Excellence in Farming award.

Te Awahohonu Forest Trustee, Bob Cottrell says a core focus for the Trust is thinking about future generations and investing in good farming practices for the next 100 years.

"Having trust in our breeders and genetics is all part of our plan for long term sustainability. We want to build a successful platform to which our children and grandchildren can also build on."

Tarawera Station is a medium to steep hill country farm and sits along State Highway 5 on the Napier-Taupo road.

Tarawera Station Manager, Carl Read-Jones puts some of the farms success down to using superior genetics.

"It goes without saying that using good genetics has improved our production. We invested in Highlander ewes, Primera rams and Red Stabilizer bulls and we are now seeing some good results."

The farms Highlander composite flock includes 16000 ewes and 5000 replacement ewe lambs. The propertys Red Stabilizer beef herd is made up of 1000 breeding cows plus heifer replacements and finishing steers and bulls.

Mr Read-Jones says the Trust goals are to make the farm a profitable and sustainable business.

"We increased our lambing percentage considerably by changing our Romney flock to a Highlander flock. The station used to struggle to get 120% lambing when it used Romneys but now the farm docks over 140% even in the 2007 drought when we felt the pinch with grass, the Highlander ewes performed well."

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Quality genetics proves successful for top Maori farmer

All About Stem Cell Therapy and Research
Hey everyone! This is our final project, a documentary about stem cell therapy and research, the difference lines of stem cells and the dilemmas. Thank you f...

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All About Stem Cell Therapy and Research - Video

Public release date: 7-Jun-2013 [ | E-mail | Share ]

Contact: Jeremy Moore jeremy.moore@aacr.org 215-446-7109 American Association for Cancer Research

PHILADELPHIA Novel abnormalities in the FGFR gene, called FGFR fusions, were identified in a spectrum of cancers, and preliminary results with cancer cells harboring FGFR fusions suggested that some patients with these cancers may benefit from treatment with FGFR inhibitor drugs, according to data published in Cancer Discovery, a journal of the American Association for Cancer Research.

FGFR genes are receptors that bind to members of the fibroblast growth factor family of proteins and play a role in key biological processes of a human cell. Because of a chromosomal abnormality, this gene sometimes fuses with another gene and forms a hybrid, or a gene fusion, resulting in a gene product with an entirely different function, causing cancers.

"We found targetable FGFR gene fusions across a diverse array of cancer types. Although rare for any individual cancer type, if found in an individual patient, these fusions are likely a major driver of that patient's cancer," said Arul M. Chinnaiyan, M.D., Ph.D., director of the Michigan Center for Translational Pathology at the University of Michigan in Ann Arbor. "We were surprised to find so many different FGFR fusions in so many different cancers.

"This study demonstrates the benefit of broad-based sequencing efforts in personalized oncology. It has the potential to identify novel, rare mutations that are 'actionable' therapeutic targets," Chinnaiyan added. "Such advances in sequencing technology facilitate rational precision therapies for individuals with late-stage cancer."

The Michigan Oncology Sequencing Program (MI-ONCOSEQ) facilitates integrative sequencing analysis of tumors from patients with advanced cancers. More than 100 patients have been enrolled since 2011. Through the project, researchers analyze the mutational landscape of each patient's tumor and suggest clinical trials or approved drugs that might be appropriate for that patient, according to Chinnaiyan.

He and his colleagues identified novel fusions of the gene FGFR2 in the tumors of four patients recruited to MI-ONCOSEQ. Of these four patients, two had metastatic tumors of the bile duct; the third had metastatic breast cancer and the fourth had metastatic prostate cancer.

To further analyze whether FGFR fusions are present across different types of cancers, the researchers extended their assessment and analyzed data generated from an internal cohort of 322 patients, as well as from a large cohort of 2,053 patients recruited to The Cancer Genome Atlas. They identified several distinct FGFR fusions in nine different types of cancers, including bladder cancer, brain cancer and lung cancer.

Chinnaiyan and colleagues then conducted studies using cancer cells and found that the different FGFR fusion proteins all seemed to drive cancer cell proliferation by activating FGFR signaling. The researchers were able to inhibit proliferation of the cells in vitro using the FGFR inhibitors PD173074 and pazopanib. In addition, they injected mice with human cancer cells and found that the tumors grown in mice could be inhibited with PD173074.

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Clinical sequencing technology identifies new targets in diverse cancers

Engineered
By Professor Fate. http://www.albinoblacksheep.com/flash/professorfate/ This is social commentary on genetic engineering for humans, except this video contai...

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Engineered - Video

Orchestral Maneouvres in the Dark Tribute (8-bit)
A small bit from OMD #39;s Genetic Engineering in 8-bit So shut up and watch.

By: Hobbes Rolfien

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Orchestral Maneouvres in the Dark Tribute (8-bit) - Video

DNA - Science Cover of "My Oh My" by Macklemore
By J-Hi May 2013 Bio Review Hip-Hop Series #3 of 4 **This is a first draft. I plan to produce a better version this summer, but I couldn #39;t find an instrument...

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DNA - Science Cover of "My Oh My" by Macklemore - Video

World Wide March Against Monsanto - Spokane - 25 May 2013
Spokane #39;s 800 plus, part of the 2 million people, 52 countries and 436 cities March Against Monsanto. Speakers, music and more for a better world for everyon...

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World Wide March Against Monsanto - Spokane - 25 May 2013 - Video

Preimplantation Genetics Diagnosis (PGD) Laboratory at Genetics IVF Institute
This video describes how the Genetics IVF Institute #39;s PGD Laboratory processes embryo biopsy samples and interprets the results.

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Preimplantation Genetics Diagnosis (PGD) Laboratory at Genetics

Genetics Smart Test 4 , NEET biology 2013 test paper
Napellus Edutech #39;s Biology Smart Test Demos.

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Genetics Smart Test 2 , exam paper for NEET biology
Napellus Edutech #39;s Biology Smart Test Demos.

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Genetics Smart Test 2 , exam paper for NEET biology - Video

Genetics Smart Test 5 , how to prepare for NEET
Napellus Edutech #39;s Biology Smart Test Demos.

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