Archive for the ‘Gene Therapy Research’ Category
5. Reproductive Key Performance Indicators – Video
5. Reproductive Key Performance Indicators
By: Alta Genetics
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1000 watt multi strain week 4ish? :) – Video
1000 watt multi strain week 4ish? 🙂
Quick look at progress in the experiment room. This round I #39;m using a microbial tea purchased at the cannabis cup from Kyle kushman. OG micro tea from Sonoma...
By: tdk74
Pascal Laforet – First National Congress GFB – April 19 2013 – Video
Pascal Laforet - First National Congress GFB - April 19 2013
A phase I trial of AAV1- gamma;-sarcoglycan gene therapy for limb girdle muscular dystrophy type 2C.
By: Beatrice Vola
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Pascal Laforet - First National Congress GFB - April 19 2013 - Video
Life Science Video Part 1 – Video
Life Science Video Part 1
Human Gene Therapy.
By: Regina Liu
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Life Science Video Part 1 - Video
Goodie Mob – Cell Therapy (Chopped and Screwed by King Koby) – Video
Goodie Mob - Cell Therapy (Chopped and Screwed by King Koby)
Goodie Mob - Cell Therapy Track #8 #GrewUpSCREWEDUP.
By: koby409
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Goodie Mob - Cell Therapy (Chopped and Screwed by King Koby) - Video
BBC iScience Stem Cell Therapy – Video
BBC iScience Stem Cell Therapy
A fun, engaging and relevant programme, inspiring the viewer to consider the science within and how scientific process can be used to test ideas and develop theories, rather than just looking...
By: Lammas Science
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BBC iScience Stem Cell Therapy - Video
Lewis County man hopes for stem cell therapy
VANCEBURG | A Lewis County man is working his way toward stem cell therapy in an attempt to help him walk again.
Jennifer Richardson, a long-time friend of Anthony Schumacher, said Schumacher was involved in an accident in December 2012, which left him paralyzed.
According to Richardson, Schumacher was in a comma for a few days and has no memory of the accident.
"He was going to work when his tire blew out and he wrecked the car," Richardson said. "He was in a coma for days and when he woke up he was paralyzed from the belly button down and couldn't remember anything."
Tammy Moore, Schumacher's mother, said he keeps a positive attitude about his situation.
"He's a happy person," she said. "He works out everyday and tries to learn new things about his situation and the procedure."
Moore said she would like to see Schumacher get the therapy.
"I don't know a lot about it. I'm still learning about it," she said. "But, from what I've seen, it's a good thing that can help him get at least some of the feeling back, if not all. I want to see him get it, if it can help."
Schumacher said he looks forward to the possibility of the procedure, too.
"I'm hopeful," he said. "I want to get it done. I've been trying to do my research and I would like to do this."
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Lewis County man hopes for stem cell therapy
Gearing Up to Make Waves Against Cancer – Video
Gearing Up to Make Waves Against Cancer
Watch more and discuss: http://greenwich.itsrelevant.com/content/14630/gearing-up-to-make-waves-against-cancer "Swim Across America is getting ready to make ...
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Gene-Based Blood Test Might Help Spot Colon Cancer
FRIDAY, June 7 (HealthDay News) -- Researchers in South Korea say they've developed a blood test that spots genetic changes that signal the presence of colon cancer.
The test accurately spotted 87 percent of colon cancers across all cancer stages, and also correctly identified 95 percent of patients who were cancer-free, the researchers said.
Colon cancer remains the second leading cancer killer in the United States, after lung cancer. According to the U.S. Centers for Disease Control and Prevention, nearly 137,000 Americans were diagnosed with the disease in 2009; 40 percent of people diagnosed will die from the disease.
Right now, invasive colonoscopy remains the "gold standard" for spotting cancer early, although fecal occult blood testing (using stool samples) also is used. What's needed is a highly accurate but noninvasive testing method, experts say.
The new blood test looks at the "methylation" of genes, a biochemical process that is key to how genes are expressed and function. Investigators from Genomictree Inc. and Yonsei University College of Medicine in Seoul said they spotted a set of genes with patterns of methylation that seems to be specific to tissues from colon cancer tumors. Changes in one gene in particular, called SDC2, seemed especially tied to colon cancer growth and spread.
As reported in the July issue of the Journal of Molecular Diagnostics, the team tested the gene-based screen in tissues taken from 133 colon cancer patients. As expected, tissues taken from colon cancer tumors in these patients showed the characteristic gene changes, while samples taken from adjacent healthy tissues did not.
More important, the same genetic hallmarks of colon cancer (or their absence) "could be measured in [blood] samples from colorectal cancer patients and healthy individuals," the researchers said in a journal news release.
The test was able to detect stage 1 cancer 92 percent of the time, "indicating that SDC2 is suitable for early detection of [colorectal cancer] where therapeutic interventions have the greatest likelihood of curing the patient from the disease," study lead author TaeJeong Oh said in the news release.
Oh said the test could be used either in addition to conventional colonoscopy or perhaps as an alternative.
Experts were cautious about the potential utility of the new test.
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Gene-Based Blood Test Might Help Spot Colon Cancer
Scientists ID Gene Behind Early Onset Puberty
WEDNESDAY, June 5 (HealthDay News) -- Scientists say they've identified a gene mutation behind a condition that causes children to undergo puberty before the age of 9.
The condition, known as central precocious puberty, appears to be inherited via a gene passed along by fathers, say researchers reporting online June 5 in the New England Journal of Medicine.
Besides helping children with central precocious puberty, "these findings will open the door for a new understanding of what controls the timing of puberty" generally, co-senior study author Dr. Ursula Kaiser, chief of the endocrinology, diabetes and hypertension division at Brigham and Women's Hospital in Boston, said in a hospital news release.
According to the authors, the mutation leads to the start of puberty before age 8 in girls and before age 9 in boys. That's earlier than the typical onset of puberty, which begins in girls between ages 8 and 13 and in boys between ages 9 and 14.
The study included genetic analyses of 40 people from 15 families with a history of early puberty. In five of the 15 families, the researchers discovered four mutations in the MKRN3 gene. A mutation in the MKRN3 gene can lead to premature activation of reproductive hormones and trigger early puberty, the study authors explained in the news release.
All of the people with the MKRN3 mutations inherited them from their fathers.
One expert who reviewed the research said the finding should be a great advance for children with central precocious puberty.
Testing children for the MKRN3 mutation "may help in the diagnosis, preventing the use of extensive testing and procedures such as MRI of the head," explained Dr. Patricia Vuguin, pediatric endocrinologist at Steven & Alexandra Cohen Children's Medical Center of New York, in New Hyde Park, N.Y.
She said better diagnostic tests would help spot patients at risk for early puberty and problems that often accompany it, such as short stature, psychological issues and other possible health issues. More generally, "the diagnosis will also help understand the role of this gene and other associated genes on how and when kids go into puberty, an area that is currently not clear," Vuguin said.
The findings will also be presented June 17 at the Endocrine Society's annual meeting.
WADA optimistic about gene-doping detection research
Beijing, Jun 7 (IANS): Terming researches in gene-doping detection as promising, the World Anti-Doping Agency (WADA) has hoped that a reliable test could be ready for the Rio summer Olympic Games.
WADA vice president Arne Ljungqvist said Thursday that they were on path to detect gene-doping, a side-door of gene therapy to enhance athletes' sports performance by manipulating their genes, reports Xinhua.
"It is always difficult to predict when something is ready, validated and possibly used. Sometimes it goes much quicker than expected, sometimes you meet obstacles that are not foreseen," said the Swede after the fourth Gene and Cell Doping Symposium.
WADA has invested about $15 million into research since it first held a gene-doping symposium in 2002, when gene therapy had just taken its first step.
"I hope we are not very far from it. It is a very vague promise but we had a hope that for the next edition of the Games, we will have a proper method in place," said Ljunquivst, who also chairs International Olympic Committee's medical commission. "That is the message we are sending and a mission we are working hard on."
Theodore Friedmann, WADA's gene and cell doping panel head, said scientists involved in the project are making "major breakthroughs in lab level" but a test must be "accurate and fair and avoid too many false positives" before application.
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WADA optimistic about gene-doping detection research
Genetic Engineering – A-Level (A2) Biology Revision – Video
Genetic Engineering - A-Level (A2) Biology Revision
Genetic Engineering. A2 Biology. OCR Exam Board. Unit 5.2.3. F215. The "You need to know..." section has come from the OCR specification.
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Genetic Engineering - A-Level (A2) Biology Revision - Video
Genetic Engineering Smart Test 1 , sample papers for NEET exam – Video
Genetic Engineering Smart Test 1 , sample papers for NEET exam
Napellus Edutech #39;s Biology Smart Test Demos.
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Genetic Engineering Smart Test 1 , sample papers for NEET exam - Video
Genetic tests offer both opportunites and dilemmas
Marla Dansky is scheduled for two rounds of surgery this summer, shortly after she completes chemotherapy treatments for a tumor in her left breast.
Her first operation at Duke Cancer Center will remove both breasts. A second will take out her ovaries and uterus, which are not cancerous but are likely to develop the disease, based on genetic tests that show she carries a faulty BRCA1 gene.
"It's the best pre-emptive strike that I have," Dansky, 40, said of her decision to undergo a complete hysterectomy in addition to bilateral breast surgery. "My plan is to 'do cancer' once, and do it right the first time."
The strong link between the BRCA1 gene and cancer, as well as the option to sidestep much of the risk through elective surgery, grabbed headlines recently when actress Angelina Jolie made public her decision to undergo a double mastectomy.
But the procedure isn't only available to movie stars. More than a third of women who test positive for BRCA1 are choosing preventative surgeries -- largely because the gene mutation raises the typical 10 percent risk of female breast cancer to something closer to 80 percent, according to the National Cancer Institute.
Screening for breast cancer is now one of more than 1,000 genetic tests available to evaluate health risks. Such tests offer unprecedented opportunities to take steps to avoid serious illness in many cases, but they pose dilemmas for patients facing a high risk for diseases with no known cure.
Individuals seeking more general clues to their genetic profiles, for example, are turning to direct-to-consumer testing companies. A number of companies offer to scan blood or saliva samples for indications of risk for common diseases such as macular degeneration or diabetes, as well as more serious conditions such as cancer or Parkinson's disease.
One such testing company, the Web-based 23andMe, evaluates genetic indicators for health, ancestry and other traits using saliva samples sent in by customers, said company spokeswoman Catherine Afarian.
In 2007, when the testing was first offered, the service produced 14 reports for $999. Now more than 240 reports are available for $99, Afarian said.
"It's a reflection of the amount of research that is being done in the field of genetics," she said.
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Genetic tests offer both opportunites and dilemmas
Common genetic disease linked to father's age
Public release date: 6-Jun-2013 [ | E-mail | Share ]
Contact: Robert Perkins perkinsr@usc.edu 213-740-9226 University of Southern California
Scientists at USC have unlocked the mystery of why new cases of the genetic disease Noonan Syndrome are so common: a mutation that causes the disease disproportionately increases a normal father's production of sperm carrying the disease trait.
When this Noonan syndrome mutation arises in a normal sperm stem cell it makes that cell more likely to reproduce itself than stem cells lacking the mutation. The father then is more likely to have an affected child because more mutant stem cells result in more mutant sperm. The longer the man waits to have children the greater the chance of having a child with Noonan syndrome.
Noonan Syndrome is among the most common genetic diseases with a simple inheritance pattern. About one of every 4,000 live births is a child with a new disease mutation. The disease can cause craniofacial abnormalities, short stature, heart defects, intellectual disability and sometimes blood cancers.
By examining the testes from 15 unaffected men, a team led by USC molecular and computational biologists Norman Arnheim and Peter Calabrese found that the new mutations were highly clustered in the testis, and that the overall proportion of mutated stem cells increased with age. Their computational analysis indicated that the mutation gave a selective edge over non-mutated cells.
"There is competition between stem cells with and without the mutation in each individual testis," said Arnheim, who has joint appointments at the USC Dornsife College of Letters, Arts and Sciences and the Keck School of Medicine of USC. "But what is also unusual in this case is that the mutation which confers the advantage to testis stem cells is disadvantageous to any offspring that inherits it."
The new findings also suggest an important new molecular mechanism to explain how certain genetic disease mutations can alter sperm stem cell function leading to exceptionally high frequencies of new cases every generation.
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The Arnheim and Calabrese team included USC postdoctoral research associates Song-Ro Yoon, and Soo-Kung Choi, graduate student Jordan Eboreime and Dr. Bruce D. Gelb of the Icahn School of Medicine at Mount Sinai in New York City. A paper detailing their research will be published on June 6 in The American Journal of Human Genetics.
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Common genetic disease linked to father's age
Genetic quirks identified with a unique blueprint
Empowered: Howard Jacob can tackle problems before they arrive. Photo: Joe Armao
American geneticist Howard Jacob has glimpsed the future. Without medical motivation, he has had his genome sequenced and now carries his genetic profile around with him via an app on his tablet.
''Within a decade this is going to be common,'' Professor Jacob said. ''And if you want to get the most bang for your buck, you'd do it on the day that a baby is born.''
Genomics involves the study of the genome: the body's genetic blueprint. How a genome is assembled is different for every person.
After having his genome sequenced last year, Professor Jacob learnt of the genetic quirks that lurked in his family tree, including a predisposition to breast cancer for his female relatives.
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The genetics field is developing so rapidly that, like any other app on his tablet, Professor Jacobs needs to update the data.
On Wednesday, not long after arriving in Melbourne from Wisconsin, he learnt he was susceptible to Creutzfeldt-Jakob disease - also known as mad cow disease.
It sounds grim, but for Professor Jacob the information is empowering. It allows problems to be tackled before they arrive and for lifestyle choices to be made to reduce risk.
He also points out that the presence of a genetic variation doesn't guarantee a disease will develop.
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Genetic quirks identified with a unique blueprint
pathophysiology 12 Molecular genetics overview – Video
pathophysiology 12 Molecular genetics overview
By: itskind alike
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pathophysiology 12 Molecular genetics overview - Video
Carmichael C (2013): Leukaemia genetics – Video
Carmichael C (2013): Leukaemia genetics
Walter and Eliza Hall Institute Postgraduate lecture 6 May 2013 Dr Catherine Carmichael Postdoctoral Fellow, Kile Laboratory Walter and Eliza Hall Institute.
By: WalterandElizaHall
Genetics – Mendelian 1 of 2 – Video
Genetics - Mendelian 1 of 2
Genetics - Mendelian 1 of 2.
By: T. Heath Ogden
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Genetics - Mendelian 1 of 2 - Video
Genetics Smart Test 8 , best book for NEET – Video
Genetics Smart Test 8 , best book for NEET
Napellus Edutech #39;s Biology Smart Test Demos.
By: NEET
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Genetics Smart Test 8 , best book for NEET - Video
lyrics- Genetics Rap – Video
lyrics- Genetics Rap
here is the lyric video.
By: Cindy Lay
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lyrics- Genetics Rap - Video
Laflamme Genetics mystery – Video
Laflamme Genetics mystery
Using science and genetics to determine rightful parents.
By: Penoblafs
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Laflamme Genetics mystery - Video
All Out Warfare at Apex Genetics – Video
All Out Warfare at Apex Genetics
Normally I won #39;t upload videos this long but this fight on Apex Genetics was so intense I decided to just do the whole thing.
By: zoid34
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All Out Warfare at Apex Genetics - Video