Archive for the ‘Gene Therapy Research’ Category

Cell Therapy Shows Promise for Acute Type of Leukemia

By: michael koons

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Cell Therapy Shows Promise for Acute Type of Leukemia - Video

Virgil discusses his combination cell therapy by Dr Harry Adelson
Virgil discusses his combination cell therapy from Dr Harry Adelson for arthritis of his knee. Dr Adelson practices in Park City, Utah. He has been performin...

By: Harry Adelson

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Virgil discusses his combination cell therapy by Dr Harry Adelson - Video

Stem Cell Therapy for Pets -- Midnight Before After
Amazing before and after footage of Midnight, a dog who received stem cell therapy for her arthritic joints. We discovered a side benefit of better skin and ...

By: NewmanVets

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Stem Cell Therapy for Pets -- Midnight Before

The Consumer By Linda Bolido Philippine Daily Inquirer

All the publicity about stem-cell therapy (SCT), including endorsements from some of the countrys most powerful people and brightest stars, has made it seem like a miracle cure, even a cure-all.

From the treatment of life-threatening medical problems to reversing the effects of aging, people are now beginning to look to SCTespecially if they can afford itfor salvation.

But, according to a doctor I know, there are actually only two proven applications for the therapy right now. The rest, at this stage, is really still experimental. People have, of course, volunteered for pioneering procedures, hoping for a cure for whatever ails them.

Education still needed

Thats well and good, as long as they are fully informed and give their unequivocal consent to being experimented on. The problem, however, is some people undergo the therapy without fully understanding it. And there are groups that seem to think that because they have Googled the therapy and read everything on the Net about it, they are capable of doing the procedure.

I mentioned in this column previously that even beauty parlors were offering to do SCT. Although it would be only for cosmetic purposes, the procedure is too new and complex to leave in the hands of beauticians.

Finally, the Department of Health has issued rules and regulations to regulate the SCT practice, a move warmly welcomed by the medical community, particularly the Philippine Medical Association and Philippine Society for Stem Cell Medicine, which expressed concern before that the popularity of SCT would lead to abuse and illegal practice if left unregulated.

Health Secretary Enrique Ona, in published reports, said the guidelines aimed to safeguard the welfare of our patients and the general public by making [sure] safe, effective and ethical stem-cell modalities and practices are within emerging international and global standards considering the very complex nature of this therapy.

Among other things, the rules restrict the use of genetically altered stem cells and tissues of human adults and the umbilical cord, fat-derived human stem cells and live animal stem cells.

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New rules will regulate stem- cell therapy use

Released: 3/20/2013 3:50 PM EDT Embargo expired: 3/27/2013 12:00 PM EDT Source Newsroom: Mayo Clinic

http://www.mayoclinic.org/news2013-rst/7384.html

Newswise ROCHESTER, Minn. -- Researchers at Mayo Clinic Cancer Center have identified a novel gene that can contribute to a womans susceptibility for developing ovarian cancer. Researchers identified the gene, called HNF1B, through large-scale analysis of more than 16,000 women with ovarian cancer and more than 26,000 healthy women. Results of the study are published in the current issue of the journal Nature Communications.

The study is one of 13 papers to be published simultaneously in five journals by the Collaborative Oncological Gene-environment Study (COGS), an international research collaboration involving investigators from Europe, Asia, Australia and North America, including Mayo Clinic. This landmark series of papers provides genotyping results from more than 250,000 individuals that look at DNA sequences involved in three hormone-related cancers: ovarian, breast and prostate.

Through the combined efforts of this consortium, and all the data sharing, we are much closer to understanding the inherited factors in these diseases, says Mayo Clinic investigator Ellen Goode, Ph.D., senior author of the HNF1B paper, and co-author of three additional papers among the 13, focusing on ovarian and breast cancer development. Ovarian cancer is the most common cause of death from gynecological cancers in the U.S.

In their study, Dr. Goode and her collaborators showed that variations in the HNF1B gene are overrepresented in one type of epithelial ovarian cancer and underrepresented in another type. They also found that variation in DNA methylation, a process that moderates the expression of genes such as HNF1B, correlates with different ovarian cancer subtypes. This finding suggests that the activation and inhibition of gene expression by DNA methylation can be as important a factor in cancer as genetic mutations.

The distinct methylation patterns suggest a molecular mechanism by which changes in this gene lead to increased cancer risk, says Dr. Goode. This has potential clinical implications for improving our understanding of how the disease begins, for better identification of ovarian cancer subtypes and for developing novel treatment approaches.

Celeste Leigh Pearce, Ph.D., of the Keck School of Medicine, University of Southern California, Los Angeles, is co-senior author of the study. Other co-authors of COGS papers include Fergus Couch, Ph.D.; Julie Cunningham, Ph.D.; Kimberly Kalli, Ph.D.; Janet Olson, Ph.D.; Susan Slager, Ph.D.; Stephen Thibodeau, Ph.D.; and Celine Vachon, Ph.D.; all of Mayo Clinic.

Funding for the study came from the Ovarian Cancer Research Fund, the Genetic Associations and Mechanisms in Oncology (GAME-ON) Network (U19 CA148112), the European Union Seventh Framework, Cancer Research UK, the Mayo Clinic Ovarian Cancer SPORE (P50 CA136393), and the National Cancer Institute (R01 CA122443), the Fred C. and Katherine B. Andersen Foundation, and the Minnesota Ovarian Cancer Alliance.

About Mayo Clinic Cancer Center As a leading institution funded by the National Cancer Institute, Mayo Clinic Cancer Center conducts basic, clinical and population science research, translating discoveries into improved methods for prevention, diagnosis, prognosis and therapy. For information on cancer clinical trials, call 507-538-7623.

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Novel Gene Drives Development of Different Types of Ovarian Cancer

SAN DIEGO--(BUSINESS WIRE)--

Illumina, Inc. (ILMN) announced that its iCOGS custom array was used to identify genetic variants related to breast, ovary and prostate cancer as part of the Collaborative Oncological Gene-Environment Study (COGS), the results of which were published today in Nature Genetics and other leading journals.1 Developed in collaboration with four large consortia2 involved in the study, the iCOGS array enables significant advances in understanding the genetic basis of cancer.

Specifically, the iCOGS array identifies single-nucleotide polymorphisms (SNPs) across selected regions of DNA associated with cancer.Its 200,000 SNPs were drawn from previous genome-wide association studies of the different cancer types and subtypes; associations with disease survival or other traits that are associated with risk of cancer; and functional candidates. The technology was used to test more than 200,000 individuals participating in the COGS.

This groundbreaking study demonstrates how genomic technology is advancing cancer research, said Jay Flatley, Illuminas President and Chief Executive Officer. We applaud the efforts of the consortia, and are pleased the iCOGS array played a role in enabling this research that ultimately will help patients.

The COGS findings include a striking increase in the number of genetic associations for breast, ovarian and prostate cancer nearly doubling the number of known susceptibility regions. The findings also provide insights into the differences between subtypes of cancer, including those revealed from comparisons of Estrogen Receptor+ and Estrogen Receptor- breast cancers, as well as the pathways and mechanisms involved in susceptibility to these common cancers.

David Bentley, Vice President and Chief Scientist at Illumina added, The partnership of the consortia and their work with us unified an enormous depth of knowledge to create a single, specialized array for application to the entire study cohort. Ultimately, we believe the results of the COGS have significant implications in the understanding and management of cancer.

To read the papers, visit: http://www.nature.com/icogs/.

About Illumina

Illumina (www.illumina.com) is a leading developer, manufacturer, and marketer of life science tools and integrated systems for the analysis of genetic variation and function. We provide innovative sequencing and array-based solutions for genotyping, copy number variation analysis, methylation studies, gene expression profiling, and low-multiplex analysis of DNA, RNA, and protein. We also provide tools and services that are fueling advances in consumer genomics and diagnostics. Our technology and products accelerate genetic analysis research and its application, paving the way for molecular medicine and ultimately transforming healthcare.

Forward-Looking Statements

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Illumina Technology Enables Findings of the Collaborative Oncological Gene -Environment Study (COGS)

Public release date: 27-Mar-2013 [ | E-mail | Share ]

Contact: Joe Dangor newsbureau@mayo.edu 507-284-5005 Mayo Clinic

ROCHESTER, Minn. -- Researchers at Mayo Clinic Cancer Center have identified a novel gene that can contribute to a woman's susceptibility for developing ovarian cancer. Researchers identified the gene, called HNF1B, through large-scale analysis of more than 16,000 women with ovarian cancer and more than 26,000 healthy women. Results of the study are published in the current issue of the journal Nature Communications.

The study is one of 13 papers to be published simultaneously in five journals by the Collaborative Oncological Gene-environment Study (COGS), an international research collaboration involving investigators from Europe, Asia, Australia and North America, including Mayo Clinic. This landmark series of papers provides genotyping results from more than 250,000 individuals that look at DNA sequences involved in three hormone-related cancers: ovarian, breast and prostate.

"Through the combined efforts of this consortium, and all the data sharing, we are much closer to understanding the inherited factors in these diseases," says Mayo Clinic investigator Ellen Goode, Ph.D., senior author of the HNF1B paper, and co-author of three additional papers among the 13, focusing on ovarian and breast cancer development. Ovarian cancer is the most common cause of death from gynecological cancers in the U.S.

In their study, Dr. Goode and her collaborators showed that variations in the HNF1B gene are overrepresented in one type of epithelial ovarian cancer and underrepresented in another type. They also found that variation in DNA methylation, a process that moderates the expression of genes such as HNF1B, correlates with different ovarian cancer subtypes. This finding suggests that the activation and inhibition of gene expression by DNA methylation can be as important a factor in cancer as genetic mutations.

"The distinct methylation patterns suggest a molecular mechanism by which changes in this gene lead to increased cancer risk," says Dr. Goode. "This has potential clinical implications for improving our understanding of how the disease begins, for better identification of ovarian cancer subtypes and for developing novel treatment approaches."

###

Celeste Leigh Pearce, Ph.D., of the Keck School of Medicine, University of Southern California, Los Angeles, is co-senior author of the study. Other co-authors of COGS papers include Fergus Couch, Ph.D.; Julie Cunningham, Ph.D.; Kimberly Kalli, Ph.D.; Janet Olson, Ph.D.; Susan Slager, Ph.D.; Stephen Thibodeau, Ph.D.; and Celine Vachon, Ph.D.; all of Mayo Clinic.

Funding for the study came from the Ovarian Cancer Research Fund, the Genetic Associations and Mechanisms in Oncology (GAME-ON) Network (U19 CA148112), the European Union Seventh Framework, Cancer Research UK, the Mayo Clinic Ovarian Cancer SPORE (P50 CA136393), and the National Cancer Institute (R01 CA122443), the Fred C. and Katherine B. Andersen Foundation, and the Minnesota Ovarian Cancer Alliance.

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Novel gene drives development of different types of ovarian cancer, Mayo-led study finds

A microscopic image of prostate cancer. Researchers have found new genetic markers that flag a person's susceptibility to the disease, as well as breast and ovarian cancer.

A microscopic image of prostate cancer. Researchers have found new genetic markers that flag a person's susceptibility to the disease, as well as breast and ovarian cancer.

The largest gene-probing study ever done has fished out dozens of new genetic markers that flag a person's susceptibility to breast, ovarian and prostate cancer.

The 74 newly discovered genetic variants double the previously known number for these malignancies, all of which are driven by sex hormones.

Underscoring the sheer magnitude of the findings, they're contained in 15 scientific papers published simultaneously by five different journals. The Nature group of journals has collected them all here.

But while the discovery is a landmark in cancer genetics, knowing these susceptibility markers won't translate into much for patients for now.

The nearest hope is that the growing catalog of markers will allow researchers to fine-tune screening tests for these cancers. They might be able to identify which people to screen using existing tools such as mammography, PSA blood tests or ultrasound. And a patient's genetic profile could help determine what to do when a screening test comes back positive.

For instance, one paper suggests that if a woman's genes contain one of four newly discovered variants, she's at risk for a more aggressive type of breast cancer called ER-negative, which accounts for about one in four cases. So she might be advised to have earlier or more frequent mammograms.

But Douglas Easton of Cambridge University, an author of one new paper, cautions that there are "many hurdles" before these genetic signals can be incorporated into breast cancer screening. "If you're 40-years-old, I think it would be in your lifetime," Easton told reporters on a conference call. "It will take some time."

The same is true for men with prostate cancer, who are currently bedeviled by the ambiguities of a screening test called PSA. Right now, a test that finds an elevated PSA doesn't indicate if a man actually has prostate cancer, or whether it's a slow-growing or aggressive type.

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Catalog Of Gene Markers For Some Cancers Doubles In Size

Mar. 26, 2013 Pediatric researchers, investigating the biology of brain tumors in children, are finding that crucial differences in how the same gene is mutated may call for different treatments. A new study offers glimpses into how scientists will be using the ongoing flood of gene-sequencing data to customize treatments based on very specific mutations in a child's tumor.

"By better understanding the basic biology of these tumors, such as how particular mutations in the same gene may respond differently to targeted drugs, we are moving closer to personalized medicine for children with cancer," said the study's first author, Angela J. Sievert, M.D., M.P.H., an oncologist in the Cancer Center at The Children's Hospital of Philadelphia.

Sievert, working with co-first author Shih-Shan Lang, M.D., in the translational laboratory of neurosurgeon Phillip Storm, M.D., and Adam Resnick, Ph.D., published a study ahead of print today in the Proceedings of the National Academy of Sciences.

The study, performed in cell cultures and animals, focused on a type of astrocytoma, the most common type of brain tumor in children. When surgeons can fully remove an astrocytoma (also called a low-grade glioma), a child can be cured. However, many astrocytomas are too widespread or in too delicate a site to be safely removed. Others may recur. So pediatric oncologists have been seeking better options -- ideally, a drug that can selectively and definitively kill the tumor with low toxicity to healthy tissue.

The current study focuses on mutations in the BRAF gene, one of the most commonly mutated genes in human cancers. Because the same gene is also mutated in certain adult cancers, such as melanoma, the pediatric researchers were able to make use of recently developed drugs, BRAF inhibitors, which were already being tested with some success against melanoma in adults.

The current study provides another example of the complexity of cancer: in the same gene, different mutations behave differently. Sievert and her colleagues at Children's Hospital were among several research groups who reported almost simultaneously in 2008 and 2009 that mutations in the BRAF gene were highly prevalent in astrocytomas in children. "These were landmark discoveries, because they suggested that if we could block the action of that mutation, we could develop a new, more effective treatment for these tumors," said Sievert.

However, follow-up studies in animal models were initially disappointing. BRAF inhibitors that were effective in BRAF-driven adult melanomas made brain tumors worse -- via an effect called paradoxical activation.

Further investigation revealed how tumor behavior depended on which type of BRAF mutation was involved. The first-generation drug that was effective in adult melanoma acted against point mutations in BRAF called V600E alterations. However, in most astrocytomas the mutation in the BRAF gene was different; it produced a fusion gene, designated KIAA1549-BRAF. When used against the fusion gene, the first-generation drug activated a cancer-driving biological pathway, the MAPK signaling cascade, and accelerated tumor growth.

By examining the molecular mechanisms behind drug resistance and working with the pharmaceutical industry, the current study's investigators identified a new, experimental second-generation BRAF inhibitor that disrupted the cancer-promoting signals from the fusion gene, and did not cause the paradoxical activation in the cell cultures and animal models.

This preclinical work result lays a foundation for multicenter clinical trials to test the mutation-specific targeting of tumors by this class of drugs in children with astrocytomas, said Sievert. As this effort progresses, it will benefit from CHOP's commitment to resources and collaborations that support data-intense research efforts.

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Details of gene pathways suggest fine-tuning drugs for child brain tumors

NEW YORK (AP) A huge international effort involving more than 100 institutions and genetic tests on 200,000 people has uncovered dozens of signposts in DNA that can help reveal further a person's risk for breast, ovarian or prostate cancer, scientists reported Wednesday.

It's the latest mega-collaboration to learn more about the intricate mechanisms that lead to cancer. And while the headway seems significant in many ways, the potential payoff for ordinary people is mostly this: Someday there may be genetic tests that help identify women with the most to gain from mammograms, and men who could benefit most from PSA tests and prostate biopsies.

And perhaps farther in the future these genetic clues might lead to new treatments.

"This adds another piece to the puzzle," said Harpal Kumar, chief executive of Cancer Research U.K., the charity which funded much of the research.

One analysis suggests that among men whose family history gives them roughly a 20 percent lifetime risk for prostate cancer, such genetic markers could identify those whose real risk is 60 percent.

The markers also could make a difference for women with BRCA gene mutations, which puts them at high risk for breast cancer. Researchers may be able to separate those whose lifetime risk exceeds 80 percent from women whose risk is about 20 to 50 percent. One doctor said that might mean some women would choose to monitor for cancer rather than taking the drastic step of having healthy breasts removed.

Scientists have found risk markers for the three diseases before, but the new trove doubles the known list, said one author, Douglas Easton of Cambridge University. The discoveries also reveal clues about the biological underpinnings of these cancers, which may pay off someday in better therapies, he said.

Experts not connected with the work said it was encouraging but that more research is needed to see how useful it would be for guiding patient care. One suggested that using a gene test along with PSA testing and other factors might help determine which men have enough risk of a life-threatening prostate cancer that they should get a biopsy. Many prostate cancers found early are slow-growing and won't be fatal, but there is no way to differentiate and many men have surgery they may not need.

Easton said the prospects for a genetic test are greater for prostate and breast cancer than ovarian cancer.

Breast cancer is the most common malignancy among women worldwide, with more than 1 million new cases a year. Prostate cancer is the second most common cancer in men after lung cancer, with about 900,000 new cases every year. Ovarian cancer accounts for about 4 percent of all cancers diagnosed in women, causing about 225,000 cases worldwide.

Link:
Scientists find new gene markers for cancer risk

By Ben Hirschler

LONDON (Reuters) - New research has nearly doubled the number of genetic variations implicated in breast, prostate and ovarian cancer, offering fresh avenues for screening at-risk patients and, potentially, developing better drugs.

The bumper haul of 74 gene changes that can increase risks for the three hormone-related cancers, announced by scientists on Wednesday, is the result of the largest ever study of its kind.

It follows an international project to analyze the DNA of more than 200,000 people - half of them with cancer and half from the general population - to find alterations that are more common in individuals with the disease.

Although each gene variation increases cancer risk by only a small amount, scientists calculate that the 1 percent of men carrying lots of the alterations could have a 50 percent increased risk of developing prostate cancer.

Women with multiple variants could see their risk of breast cancer increase by 30 percent.

Doug Easton of the University of Cambridge, one of the cancer researchers who led the work, said the batch of new genetic discoveries meant medical experts would be able to develop new cancer screening programs.

This will take time, since more research is needed to develop diagnostic tools.

"I would think that within five to 10 years this might be being used commonly, if not in a very widespread population base," said Paul Pharoah, also of the University of Cambridge.

Initially, the additional screening is likely to be targeted at patients with established cancer risk factors, such as carriers of BRCA gene faults. Women with BRCA faults are known to be at greater risk of developing breast and ovarian cancer.

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Record gene haul points to better cancer screening

Nephilim History part3
The truth about the demon host.

By: shieldoftheson

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Nephilim History part3 - Video

Gene modification
For more information, log on to- http://shomusbiology.weebly.com/ Download the study materials here- http://shomusbiology.weebly.com/bio-materials.html Genet...

By: Suman Bhattacharjee

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Gene modification - Video

Public release date: 27-Mar-2013 [ | E-mail | Share ]

Contact: Jordi Morato comunicacio@idibell.cat IDIBELL-Bellvitge Biomedical Research Institute

The Bellvitge Biomedical Research Institute (IDIBELL) has signed a licensing agreement with the Spanish biotech company Histocell to make use of a patent for the treatment of acute pulmonary diseases with mesenchymal stem cells. These cells, administered intravenously, have the ability to go directly to the damaged lungs, acting as a "smart drug".

To enhance the effect, researchers have modified this cells by genetic engineering. The studies have been developed by a team led by Josep Maria Aran, researcher at the Human Molecular Genetics group of IDIBELL, in collaboration with researchers of the Pneumology group at Vall d'Hebron Research Institute (VHIR) and the Biomedical Research Network Centre for Respiratory Diseases (CIBERES). The outcomes of the research have supposed an international patent application managed by the Technology Transfer Office (TTO) at IDIBELL.

The researchers use adult mesenchymal stem cells extracted from adipose tissue obtained from liposuction. These cells are capable of enhancing the regeneration of the damaged lung tissue and secrete inflammatory proteins therein when injected into the blood.

Improvements

The novelty patented by IDIBELL and VHIR researchers has been the insertion of improvements through genetic engineering that can significantly enhance the anti-inflammatory and regenerative power of the mesenchymal cells. Specifically, researchers have modified the antagonist to secrete interleukin 33, a regulatory protein (cytokine) that has a fundamental role in the inflammatory process.

The treatment has proven to be very effective given intravenously, although it could be considered the option of administering it by inhalation.

In the administered dose, these stem cells do not involve immune rejection, because the body removes them after their function is performed. This makes them particularly useful for treating acute diseases.

Good results

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IDIBELL licenses Histocell, a patent for acute respiratory diseases with stem cells

SHANGHAI, March 27, 2013 /PRNewswire/ --Life Technologies Corporation (LIFE) today announced that its Applied Biosystems 3500xL Dx Genetic Analyzer has been approved by China's State Food and Drug Administration (SFDA) for clinical diagnostic use in China and the launch of 10 Assays from its joint venture with Daan Gene. The development marks a major extension of Life Technologies' capabilities to serve the clinical end market in China with Sanger-based solutions.

The 3500xL Dx is an automated 24 capillary-based Sanger Sequencer designed for a wide range of sequencing applications. It delivers high quality performance, higher throughput and increased productivity for clinical laboratories around the world.

Together with Life Technologies' genetic analyzer 3500 Dx that was approved by SFDA for IVD use in 2011 in China, the 3500 series genetic analyzers are intended for use in a wide range of applications in the process of clinical research, including de novo sequencing and mutational profiling as well as HLA typing. The newly expanded offering of both the 3500 Dx and the 3500xL Dx provides hospitals of all sizes the flexibility they need to meet their unique throughput demands.

Based on the 3500 Dx series platform, ten assays have been developed or licensed by Guangzhou Life Technologies DaAn Diagnostics Co. Ltd, a joint venture that established in 2012 between Life Technologies and Daan Gene Co. Ltd. of Sun Yat Sen University. These assays will be used for genotypic and drug resistance testing, cancer mutation identification and the prenatal chromosome disorder detection. Currently, nine out of the ten assays are Research Use Only kits and the other one that can be used in Trisomy 21 prenatal screening for Down syndrome is SFDA registered. The company is currently conducting clinical trials and is actively seeking the SFDA approval for the remaining nine kits.

"The current approval of the 3500xL Dx by SFDA emphasizes Life Technologies' success in pursuing regulatory pathways for our diagnostics laboratory instruments as well as our vision to becoming a global leader in the molecular diagnostics industry," said Ronnie Andrews, president of Medical Sciences at Life Technologies.

"As in other countries, China is facing the challenges of fighting with infectious diseases like HBV, TB, HCV and HIV, as well as various genetic-based diseases like lung cancer, breast cancer, and ovarian cancers, etc. The early detection and treatment of these diseases will greatly increase the recovery and survival rate of patients," said Dr. Siddhartha Kadia, president of Life Technologies Greater China. "Life Technologies is committed to bring more medical diagnostic products, like the 3500xL Dx genetic analyzer to support clinical research and diagnostics, which are expected to lead to a higher quality of life for Chinese people and more economical healthcare solutions."

Applied Biosystems Sanger Sequencers supplied the technology that powered the Human Genome Project, and Sanger instruments remain the sequencing "gold-standard" for accuracy, reliability and ease of use. The participation of the sequencing technologies in clinical diagnostics is reshaping the disease treatment paradigm worldwide.

Additional products offered by Life Technologies for the molecular diagnostics lab market in China include: the Applied Biosystem 7500, 7500 Fast Dx, StepOne, StepOne Plus, ViiA7 Dx qPCR series. Veriti Dx Thermal Cycler is in the process of SFDA registration in China.

About Life Technologies Life Technologies Corporation(NASDAQ:LIFE) is a global biotechnology company that is committed to providing the most innovative products and services to leading customers in the fields of scientific research, genetic analysis and applied sciences. With a presence in more than 180 countries, the company's portfolio of 50,000 end-to-end solutions is secured by more than 5,000 patents and licenses that span the entire biological spectrum -- scientific exploration, molecular diagnostics, 21stcentury forensics, regenerative medicine and agricultural research. Life Technologies has approximately 10,000 employees and had sales of $3.8 billion in 2012.

Life Technologies' Safe Harbor Statement This press release includes forward-looking statements about Life Technologies' anticipated results that involve risks and uncertainties. Some of the information contained in this press release, including, but not limited to, statements as to industry trends and Life Technologies' plans, objectives, expectations and strategy for its business, contains forward-looking statements that are subject to risks and uncertainties that could cause actual results or events to differ materially from those expressed or implied by such forward-looking statements. Any statements that are not statements of historical fact are forward-looking statements. When used, the words "believe," "plan," "intend," "anticipate," "target," "estimate," "expect" and the like, and/or future tense or conditional constructions ("will," "may," "could," "should," etc.), or similar expressions, identify certain of these forward-looking statements. Important factors which could cause actual results to differ materially from those in the forward-looking statements are detailed in filings made byLife Technologies with the Securities and Exchange Commission.Life Technologies undertakes no obligation to update or revise any such forward-looking statements to reflect subsequent events or circumstances.

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Life Technologies Announces SFDA Clearance for its 3500xL Dx Genetic Analyzer in China and the Launch of 10 Assays ...

NEW YORK (AP) A huge international effort involving more than 100 institutions and genetic tests on 200,000 people has uncovered dozens of signposts in DNA that can help reveal further a person's risk for breast, ovarian or prostate cancer, scientists reported Wednesday.

It's the latest mega-collaboration to learn more about the intricate mechanisms that lead to cancer. And while the headway seems significant in many ways, the potential payoff for ordinary people is mostly this: Someday there may be genetic tests that help identify women with the most to gain from mammograms, and men who could benefit most from PSA tests and prostate biopsies.

And perhaps farther in the future these genetic clues might lead to new treatments.

"This adds another piece to the puzzle," said Harpal Kumar, chief executive of Cancer Research U.K., the charity which funded much of the research.

One analysis suggests that among men whose family history gives them roughly a 20 percent lifetime risk for prostate cancer, such genetic markers could identify those whose real risk is 60 percent.

The markers also could make a difference for women with BRCA gene mutations, which puts them at high risk for breast cancer. Researchers may be able to separate those whose lifetime risk exceeds 80 percent from women whose risk is about 20 to 50 percent. One doctor said that might mean some women would choose to monitor for cancer rather than taking the drastic step of having healthy breasts removed.

Scientists have found risk markers for the three diseases before, but the new trove doubles the known list, said one author, Douglas Easton of Cambridge University. The discoveries also reveal clues about the biological underpinnings of these cancers, which may pay off someday in better therapies, he said.

Experts not connected with the work said it was encouraging but that more research is needed to see how useful it would be for guiding patient care. One suggested that using a gene test along with PSA testing and other factors might help determine which men have enough risk of a life-threatening prostate cancer that they should get a biopsy. Many prostate cancers found early are slow-growing and won't be fatal, but there is no way to differentiate and many men have surgery they may not need.

Easton said the prospects for a genetic test are greater for prostate and breast cancer than ovarian cancer.

Breast cancer is the most common malignancy among women worldwide, with more than 1 million new cases a year. Prostate cancer is the second most common cancer in men after lung cancer, with about 900,000 new cases every year. Ovarian cancer accounts for about 4 percent of all cancers diagnosed in women, causing about 225,000 cases worldwide.

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Scientists find new genetic markers for cancer

NEW YORK, N.Y. - A huge international effort involving more than 100 institutions and genetic tests on 200,000 people has uncovered dozens of signposts in DNA that can help reveal further a person's risk for breast, ovarian or prostate cancer, scientists reported Wednesday.

It's the latest mega-collaboration to learn more about the intricate mechanisms that lead to cancer. And while the headway seems significant in many ways, the potential payoff for ordinary people is mostly this: Someday there may be genetic tests that help identify women with the most to gain from mammograms, and men who could benefit most from PSA tests and prostate biopsies.

And perhaps farther in the future these genetic clues might lead to new treatments.

"This adds another piece to the puzzle," said Harpal Kumar, chief executive of Cancer Research U.K., the charity which funded much of the research.

One analysis suggests that among men whose family history gives them roughly a 20 per cent lifetime risk for prostate cancer, such genetic markers could identify those whose real risk is 60 per cent.

The markers also could make a difference for women with BRCA gene mutations, which puts them at high risk for breast cancer. Researchers may be able to separate those whose lifetime risk exceeds 80 per cent from women whose risk is about 20 to 50 per cent. One doctor said that might mean some women would choose to monitor for cancer rather than taking the drastic step of having healthy breasts removed.

Scientists have found risk markers for the three diseases before, but the new trove doubles the known list, said one author, Douglas Easton of Cambridge University. The discoveries also reveal clues about the biological underpinnings of these cancers, which may pay off someday in better therapies, he said.

Experts not connected with the work said it was encouraging but that more research is needed to see how useful it would be for guiding patient care. One suggested that using a gene test along with PSA testing and other factors might help determine which men have enough risk of a life-threatening prostate cancer that they should get a biopsy. Many prostate cancers found early are slow-growing and won't be fatal, but there is no way to differentiate and many men have surgery they may not need.

Easton said the prospects for a genetic test are greater for prostate and breast cancer than ovarian cancer.

Breast cancer is the most common malignancy among women worldwide, with more than 1 million new cases a year. Prostate cancer is the second most common cancer in men after lung cancer, with about 900,000 new cases every year. Ovarian cancer accounts for about 4 per cent of all cancers diagnosed in women, causing about 225,000 cases worldwide.

The rest is here:
Scientists ID genetic markers tied to breast, prostate, ovarian cancer; no quick payoff seen

NEW YORK A huge international effort involving more than 100 institutions and genetic tests on 200,000 people has uncovered dozens of signposts in DNA that can help reveal further a person's risk for breast, ovarian or prostate cancer, scientists reported Wednesday.

It's the latest mega-collaboration to learn more about the intricate mechanisms that lead to cancer. And while the headway seems significant in many ways, the potential payoff for ordinary people is mostly this: Someday there may be genetic tests that help identify women with the most to gain from mammograms, and men who could benefit most from PSA tests and prostate biopsies.

And perhaps farther in the future these genetic clues might lead to new treatments.

"This adds another piece to the puzzle," said Harpal Kumar, chief executive of Cancer Research U.K., the charity which funded much of the research.

One analysis suggests that among men whose family history gives them roughly a 20 percent lifetime risk for prostate cancer, such genetic markers could identify those whose real risk is 60 percent.

The markers also could make a difference for women with BRCA gene mutations, which puts them at high risk for breast cancer. Researchers may be able to separate those whose lifetime risk exceeds 80 percent from women whose risk is about 20 to 50 percent. One doctor said that might mean some women would choose to monitor for cancer rather than taking the drastic step of having healthy breasts removed.

Scientists have found risk markers for the three diseases before, but the new trove doubles the known list, said one author, Douglas Easton of Cambridge University. The discoveries also reveal clues about the biological underpinnings of these cancers, which may pay off someday in better therapies, he said.

Experts not connected with the work said it was encouraging but that more research is needed to see how useful it would be for guiding patient care. One suggested that using a gene test along with PSA testing and other factors might help determine which men have enough risk of a life-threatening prostate cancer that they should get a biopsy. Many prostate cancers found early are slow-growing and won't be fatal, but there is no way to differentiate and many men have surgery they may not need.

Easton said the prospects for a genetic test are greater for prostate and breast cancer than ovarian cancer.

Breast cancer is the most common malignancy among women worldwide, with more than 1 million new cases a year. Prostate cancer is the second most common cancer in men after lung cancer, with about 900,000 new cases every year. Ovarian cancer accounts for about 4 percent of all cancers diagnosed in women, causing about 225,000 cases worldwide.

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Genetic Markers For Cancer Risk Identified In Huge International Effort

Mar. 27, 2013 An international research collaboration has found five new regions of the human genome that are linked to increased risks for developing ovarian cancer. Duke Medicine researchers played a leading role analyzing genetic information from more than 40,000 women.

The findings are published in four studies, two appearing in the journal Nature Communications and two in Nature Genetics on March 27, 2013. The research is being published as part of a coordinated release of new data from the Collaborative Oncological Gene-environment Study (COGS), an international effort to identify genetic variations that make certain people susceptible to developing breast, prostate and ovarian cancers.

According to the National Cancer Institute, ovarian cancer accounts for 3 percent of all cancers in women and is the leading cause of death among cancers of the female reproductive system. This is due to the lack of early symptoms or effective screening tests.

Inherited mutations in the BRCA1 and BRCA2 genes dramatically increase ovarian cancer risk. Genetic testing for BRCA1 and BRCA2 mutations can identify women who would benefit most from surgery to prevent ovarian cancer, but this is relevant to less than 1 percent of the population. Other genetic variants that are more common may also affect ovarian risk. The Ovarian Cancer Association Consortium previously described six such genetic differences and now the COGS project has found five more.

"Because ovarian cancer is relatively uncommon, it is critically important to identify subsets of women at increased risk," said senior coauthor Andrew Berchuck, MD, director of the division of gynecologic oncology at Duke Cancer Institute. "Although the common genetic risk variants for ovarian cancer discovered thus far are not strong enough to use in practice, this may become a reality as additional variants are discovered. This could facilitate development of ovarian cancer screening and prevention strategies directed towards women most likely to benefit."

"Our hope is that these genetic variants, along with established epidemiologic factors, such as reproductive history, will not only enhance our ability to predict which women are at increased risk for developing this highly fatal disease, but will also provide new insight into the underlying biology and pathogenesis of ovarian cancer," said epidemiologist Joellen Schildkraut, PhD, director of the Cancer Control and Population Sciences program at Duke Cancer Institute. She is a senior coauthor of one of the Nature studies and the principal investigator of the North Carolina Ovarian Cancer Study, one of the studies that contributed data to this discovery.

"Because of the large number of study subjects, we were able to determine that some genetic variants were important to specific subgroups of ovarian cancer, suggesting possible differences in the underlying cause of these subtypes," Schildkraut said.

Additional studies on the biology of these genetic variants could help researchers develop new tests to predict which women are at risk of developing ovarian cancer, and potentially lead to therapies that better treat the disease.

In addition to Berchuck and Schildkraut, Duke study authors include Rachel Palmieri Weber of the Department of Community and Family Medicine and Edwin Iversen of the Department of Statistical Science and Cancer Prevention, Detection and Control Research Program.

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Five genetic variations increase risk of ovarian cancer

By Duke Medicine News and Communications

DURHAM, N.C. -- An international research collaboration has found five new regions of the human genome that are linked to increased risks for developing ovarian cancer. Duke Medicine researchers played a leading role analyzing genetic information from more than 40,000 women.

The findings are published in four studies, two appearing in the journal Nature Communications and two in Nature Genetics on March 27, 2013. The research is being published as part of a coordinated release of new data from the Collaborative Oncological Gene-environment Study (COGS), an international effort to identify genetic variations that make certain people susceptible to developing breast, prostate and ovarian cancers.

According to the National Cancer Institute, ovarian cancer accounts for 3 percent of all cancers in women and is the leading cause of death among cancers of the female reproductive system. This is due to the lack of early symptoms or effective screening tests.

Inherited mutations in the BRCA1 and BRCA2 genes dramatically increase ovarian cancer risk. Genetic testing for BRCA1 and BRCA2 mutations can identify women who would benefit most from surgery to prevent ovarian cancer, but this is relevant to less than 1 percent of the population. Other genetic variants that are more common may also affect ovarian risk. The Ovarian Cancer Association Consortium previously described six such genetic differences and now the COGS project has found five more.

"Because ovarian cancer is relatively uncommon, it is critically important to identify subsets of women at increased risk," said senior coauthor Andrew Berchuck, MD, director of the division of gynecologic oncology at Duke Cancer Institute. "Although the common genetic risk variants for ovarian cancer discovered thus far are not strong enough to use in practice, this may become a reality as additional variants are discovered. This could facilitate development of ovarian cancer screening and prevention strategies directed towards women most likely to benefit."

"Our hope is that these genetic variants, along with established epidemiologic factors, such as reproductive history, will not only enhance our ability to predict which women are at increased risk for developing this highly fatal disease, but will also provide new insight into the underlying biology and pathogenesis of ovarian cancer," said epidemiologist Joellen Schildkraut, PhD, director of the Cancer Control and Population Sciences program at Duke Cancer Institute. She is a senior coauthor of one of the Nature studies and the principal investigator of the North Carolina Ovarian Cancer Study, one of the studies that contributed data to this discovery.

"Because of the large number of study subjects, we were able to determine that some genetic variants were important to specific subgroups of ovarian cancer, suggesting possible differences in the underlying cause of these subtypes," Schildkraut said.

Additional studies on the biology of these genetic variants could help researchers develop new tests to predict which women are at risk of developing ovarian cancer, and potentially lead to therapies that better treat the disease.

In addition to Berchuck and Schildkraut, Duke study authors include Rachel Palmieri Weber of the Department of Community and Family Medicine and Edwin Iversen of the Department of Statistical Science and Cancer Prevention, Detection and Control Research Program. A full list of researchers and their affiliations can be found in the manuscripts.

Read the rest here:
Five Genetic Variations Found to Increase Risk of Ovarian Cancer

Public release date: 27-Mar-2013 [ | E-mail | Share ]

Contact: Rachel Harrison rachel.harrison@duke.edu 919-419-5069 Duke University Medical Center

DURHAM, N.C. -- An international research collaboration has found five new regions of the human genome that are linked to increased risks for developing ovarian cancer. Duke Medicine researchers played a leading role analyzing genetic information from more than 40,000 women.

The findings are published in four studies, two appearing in the journal Nature Communications and two in Nature Genetics on March 27, 2013. The research is being published as part of a coordinated release of new data from the Collaborative Oncological Gene-environment Study (COGS), an international effort to identify genetic variations that make certain people susceptible to developing breast, prostate and ovarian cancers.

According to the National Cancer Institute, ovarian cancer accounts for 3 percent of all cancers in women and is the leading cause of death among cancers of the female reproductive system. This is due to the lack of early symptoms or effective screening tests.

Inherited mutations in the BRCA1 and BRCA2 genes dramatically increase ovarian cancer risk. Genetic testing for BRCA1 and BRCA2 mutations can identify women who would benefit most from surgery to prevent ovarian cancer, but this is relevant to less than 1 percent of the population. Other genetic variants that are more common may also affect ovarian risk. The Ovarian Cancer Association Consortium previously described six such genetic differences and now the COGS project has found five more.

"Because ovarian cancer is relatively uncommon, it is critically important to identify subsets of women at increased risk," said senior coauthor Andrew Berchuck, MD, director of the division of gynecologic oncology at Duke Cancer Institute. "Although the common genetic risk variants for ovarian cancer discovered thus far are not strong enough to use in practice, this may become a reality as additional variants are discovered. This could facilitate development of ovarian cancer screening and prevention strategies directed towards women most likely to benefit."

"Our hope is that these genetic variants, along with established epidemiologic factors, such as reproductive history, will not only enhance our ability to predict which women are at increased risk for developing this highly fatal disease, but will also provide new insight into the underlying biology and pathogenesis of ovarian cancer," said epidemiologist Joellen Schildkraut, PhD, director of the Cancer Control and Population Sciences program at Duke Cancer Institute. She is a senior coauthor of one of the Nature studies and the principal investigator of the North Carolina Ovarian Cancer Study, one of the studies that contributed data to this discovery.

"Because of the large number of study subjects, we were able to determine that some genetic variants were important to specific subgroups of ovarian cancer, suggesting possible differences in the underlying cause of these subtypes," Schildkraut said.

Additional studies on the biology of these genetic variants could help researchers develop new tests to predict which women are at risk of developing ovarian cancer, and potentially lead to therapies that better treat the disease.

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5 genetic variations increase risk of ovarian cancer

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