Archive for the ‘Gene Therapy Research’ Category

The Shell Collector - Book Trailer
Trailer for the novel by John Cosper, The Shell Collector. http://www.johncosper.com Collections may seem like an odd occupation for a special forces veteran, but there #39;s nothing normal about Max Rogan #39;s job. While most collection agents are after cars and tech toys, Max #39;s quarry is a little higher end: human shells, created and cloned in a genetics lab for the purposes of organ transplants. Max never gave a second #39;s thought to the ethical questions surrounding his employer #39;s activities. But when Max finds himself under suspicion after a shell he retrieves leads a daring escape, his only choice is to go undercover and bring the anti-cloning operation down. Max #39;s journey brings him face to face with the shells who want nothing more than the chance to live as humans, and Max soon finds himself wondering if they really are a collection of organs and tissues - or real, flesh and blood humans? A fast paced page turner filled with twists and turns, The Shell Collector balances science fiction action with questions about human cloning, genetic engineering, and the brave new world looming on our horizon!

By: John Cosper

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The Shell Collector - Book Trailer - Video

Reverse Mapping (branching line method)
My students had a hard time with this genetics question. When I was marking it, it occurred to me that it might be a good idea to show three ways which can be used to solve it. This example shows how to use a branching line method for the solution. You can view this on my blog at universitygenetics-mapping which is on blogspot dot com (YouTube won #39;t let me put in the proper URL!) I #39;ll also post the way that most students started to solve it - by working backward from the mapping equation (d=#recomb/total offspring x 100) as well as a solution suggested by the textbook. You do a trihybrid cross between two organisms: abc+a+b+c with abc/abc. If the distance between ab is 6 cM and there are 22 cM between b and c, what are the numbers of progeny that you would get of each phenotypic class? Assume there are 1800 offspring in total, and that there is zero interference in the double-crossover class. Round numbers to the nearest integer (ie don #39;t use decimals).

By: Todd Nickle

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Reverse Mapping (branching line method) - Video

Office Harlem Shake Malaysia.mov
DISCLAIMER: WE ARE NOT THE ORIGINAL ARTIST OF THIS TRACK AND THIS VIDEO DOES NOT REPRESENT ANY COMPANY OR BRANDS. THE FACES HAVE BEEN MASKED TO PROTECT INDIVIDUAL RIGHTS AND UGLY GENETICS. WHAT WE JUST SAID HERE IS NOT LEGAL ADVICE. WE PRESENT THIS INFORMATION IS FOR INFORMING FOR INFORMATIONAL PURPOSES ONLY.

By: ThePartyPossum

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Office Harlem Shake Malaysia.mov - Video

Harlem Shake Tongkat Ali
DISCLAIMER: WE ARE NOT THE ORIGINAL ARTIST OF THIS TRACK AND THIS VIDEO DOES NOT REPRESENT ANY COMPANY OR BRANDS. THE FACES HAVE BEEN MASKED TO PROTECT INDIVIDUAL RIGHTS AND UGLY GENETICS. WHAT WE JUST SAID HERE IS NOT LEGAL ADVICE. WE PRESENT THIS INFORMATION IS FOR INFORMING FOR INFORMATIONAL PURPOSES ONLY.

By: ThePartyPossum

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Harlem Shake Tongkat Ali - Video

ForeBears will be released the 10th of March
The ForeBears film will be available from the 10th of March on http://www.AncestralCult.com , and NOT from Amazon as we had originally envisaged. If you wish to order 6 or more DVDs for resale, you should know that you can order from the 1st of March. SYNOPSIS : Varg VIKERNES embarks on a spiritual journey back in time, to the Stone Age (around 30 000 BC) to a previous life. He sees the distant past through the eyes of his former self, and doing so understands the meaning of the forgotten bear cult rituals, that still influences the modern mind. He discovers that these age-old rituals are the roots to all philosophies, traditions and religions. A cultural and biographical film by Marie CACHET and Varg VIKERNES With unpublished music by Varg VIKERNES In English only. Run time : 100 min approx. PAL DVD (You may have trouble playing the DVD in some DVD-players in America, where the standard is NTSC) © 2013 Marie CACHET All music by Varg VIKERNES http://WwW.AncestralCult.Com Tags : ForeBears, Varg Vikernes, Burzum, Gullaldr, Marie Cachet, Film, Movie, Atala, Stone age, European, Europe, Prehistory, Bear cult, Divje Babe, Rock carvings, Rock Art, Rock paintings, Hand, Cave, Cavern, Anthropology, Paleontology, Archeology, Population genetics, Species, Race, Neanderthal, Neandertal, Homo Sapiens, Out of Africa, Cro Magnon, DNA, Genome, Max Planck, Pääbo, Hublin, Pathou-Mathis, Humans interbred, Non-African, Autism, Asperger syndrom, Atlantis, Plato, Philosophy, Metaphysics, Darwinism, Origin ...

By: Marie Cachet

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ForeBears will be released the 10th of March - Video

fightsanfilippo. We won #39;t leave you behind
Video to denounce Goverments attitude with Sanfilippo Syndrome and other Rare Diseases. Please, help us save children lifes. Help us fund the first American Gene Therapy clinical trial to cure Sanfilippo types A and B and the next one to cure Sanfilippo C

By: fightsanfilippo

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fightsanfilippo. We won't leave you behind - Video

Baylie Faella Pre-Stem Cell Therapy at Abbott Animal Hospital in Rehoboth, MA
Baylie Faella, a 7 year old Lab pre-stem cell therapy who underwent a torn ACL repair. She also suffered from atopy (allergies) and had lesions on her body.

By: Ashraf Gomaa

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Baylie Faella Pre-Stem Cell Therapy at Abbott Animal Hospital in Rehoboth, MA - Video

Feb. 21, 2013 Cell therapy is a promising alternative to tissue and organ transplantation for diseases that are caused by death or poor functioning of cells. Considering the ethical discussions surrounding human embryonic stem cells, a lot is expected of the so-called 'induced pluripotent stem cells' (iPS cells). However, before this technique can be applied effectively, a lot of research is required into the safety and efficacy of such iPS cells. VIB scientists associated to the UGent have developed a mouse model that can advance this research to the next step.

Lieven Haenebalcke (VIB/UGent): "iPS cells have enormous therapeutic potential, but require more thorough testing before they can be used for such purposes. Using our new mouse model, we can study which mechanisms determine the identity of a cell. This knowledge is essential before we can use cell therapy for regenerative medicine."

Jody Haigh (VIB/UGent): "If we want to give cell therapy a future, then we must continue this type of research and invest in the further development of such technologies. This will result in an improved insight into cellular identity and -- in the long term -- safer options of applying iPS cells or cells derived from iPS cells in clinical studies."

Cell therapy -- replacing cells to provide a cure

Cell therapy is the replacement of lost or poorly functioning cells in patients. For example, such cell therapies could be used to repair the heart muscle after a heart attack, joints affected by arthritis, the pancreas in diabetes or the spine in certain forms of paralysis. This requires cells that are able to multiply in the laboratory and that can be converted to healthy cells of the desired cell type. Human embryonic stem cells meet these criteria, but they are ethically controversial.

iPS cells -- a promising alternative to embryonic stem cells

Shinya Yamanaka recently developed a fairly simple method to reprogram differentiated cells -- such as skin cells -- back to stem cells, so-called "induced pluripotent stem cells" (iPS cells). This earned him the Nobel Prize for Medicine in 2012 (shared with John Gurdon). These iPS cells can be generated using only 4 "reprogramming factors."

As is the case with embryonic stem cells, these iPS cells can be used to produce other cell types, such as heart muscle cells or nerve cells. They can also be cultured indefinitely and there are no ethical objections as they are not obtained from human embryos left over after IVF, but from adult individuals. Furthermore, iPS cells are obtained from the patient and this reduces the risk of rejection during therapeutic applications.

Essential research possible

Before iPS cells can be used effectively and safely as a therapy, it is essential that we gain clear insight into which molecular mechanisms determine the identity of a cell; why and how a cell develops into -- for example -- a heart muscle cell, a nerve cell or a blood cell. In order to do so, Lieven Haenebalcke and Jody Haigh have developed a mouse model that will enable them to conduct this research. They succeeded in creating iPS cells from a variety of mouse cells. Furthermore, the new model allows the investigators to replace the 4 reprogramming factors in these iPS cells efficiently with specific genes in order to create targeted different cell types, such as functional heart muscle cells.

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Cell therapy: New mouse model promises to advance research on induced pluripotent stem cells

Feb. 21, 2013 In the first human study of its kind, researchers activated heart failure patients' stem cells with gene therapy to improve their symptoms, heart function and quality of life, according to a study in the American Heart Association journal Circulation Research.

Researchers delivered a gene that encodes a factor called SDF-1 to activate stem cells like a "homing" signal.

The study is unique because researchers introduced the "homing" factor to draw stem cells to the site of injury and enhance the body's stem cell-based repair process. Generally, researchers extract and expand the number of cells, then deliver them back to the subject.

"We believe stem cells are always trying to repair tissue, but they don't do it well -- not because we lack stem cells but, rather, the signals that regulate our stem cells are impaired," said Marc S. Penn, M.D., Ph.D., Director of Research at Summa Cardiovascular Institute in Akron, Ohio, and lead author and professor of medicine at Northeast Ohio Medical University in Rootstown, Ohio.

SDF-1 is a naturally occurring protein, secreted by cells, that guides the movement of other cells. Previous research by Penn and colleagues has shown SDF-1 activates and recruits the body's stem cells, allowing them to heal damaged tissue. However, the effect may be short-lived. For example, SDF-1 that's naturally expressed after a heart attack lasts only a week.

In the study, researchers attempted to re-establish and extend the time that SDF-1 could stimulate patients' stem cells. Study participants' average age was 66 years.

Researchers injected one of three doses of the SDF-1 gene (5mg, 15mg or 30mg) into the hearts of 17 patients with symptomatic heart failure and monitored them for up to a year. Four months after treatment, they found:

"We found 50 percent of patients receiving the two highest doses still had positive effects one year after treatment with their heart failure classification improving by at least one level," Penn said. "They still had evidence of damage, but they functioned better and were feeling better."

The findings indicate people's stem cells have the potential to induce healing without having to be taken out of the body, Penn said.

"Our study also shows gene therapy has the potential to help people heal their own hearts."

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Stem cell 'homing' signal may help treat heart failure patients

Genetically Engineered Babies Lead to Evil Eugenics
Lord Robert Winston, Professor of Science and Society and Emeritus Professor of Fertility Studies at Imperial College, argues genetic engineering is a slippery slope that will lead to the return of the evil eugenics practices by the Nazis. Full video available for free at: fora.tv

By: ForaTv

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Genetically Engineered Babies Lead to Evil Eugenics - Video

Public release date: 21-Feb-2013 [ | E-mail | Share ]

Contact: Vicki Cohn vcohn@liebertpub.com 914-740-2100 x2156 Mary Ann Liebert, Inc./Genetic Engineering News

New Rochelle, NY, February 21, 2013By targeting the specific mutation that causes the hereditary neuromuscular disease myotonic dystrophy, it is possible to neutralize the mutant RNA toxicity and minimize or even eliminate the disabling symptoms of the disease. New classes of drugs called antisense oligonucleotides are being designed to achieve this. Innovative work to develop a modified antisense drug that can be administered intravenously and achieve the desired therapeutic effect is described in an article in Nucleic Acid Therapeutics, a peer-reviewed journal from Mary Ann Liebert, Inc., publishers. The article is available free on the Nucleic Acid Therapeutics website.

Andrew Leger and coauthors from Genzyme, a Sanofi Company (Framingham, MA) added a peptide to an oligonucleotide strand designed to bind to and inactivate the mutated RNA region associated with myotonic dystrophy type 1 (DM1). The disease can affect function of the heart, central nervous system, and gastrointestinal tract, and a characteristic symptom is myotonia, in which muscles are slow to relax following contraction.

In the article "Systemic Delivery of Peptide-Linked Morpholino Oligonucleotide Neutralizes Mutant RNA Toxicity in a Mouse Model of Myotonic Dystrophy," the authors describe how the peptide is intended to enable systemic delivery of the drug, protecting it from being damaged or destroyed in the body before it can reach its target, the muscles. They report that intravenous introduction of the drug in a mouse model of DM1 led to good biodistribution of the drug, evidence that the problems previously caused by RNA toxicity were corrected, and complete elimination of myotonia in the treated mice.

"One of the greatest challenges to the therapeutic use of nucleic acids is effective and safe delivery," says Executive Editor Fintan Steele, PhD, SomaLogic, Inc., Boulder, CO. "The work of Leger and his colleagues demonstrates a potentially powerful way to meet that challenge for many diseases."

###

Nucleic Acid Therapeutics is under the editorial leadership of Co-Editors-in-Chief Bruce A. Sullenger, PhD, Duke Translational Research Institute, Duke University Medical Center, Durham, NC, and C.A. Stein, MD, PhD, City of Hope National Medical Center, Duarte, CA; and Executive Editor Fintan Steele, PhD (SomaLogic, Boulder, CO).

About the Journal

Nucleic Acid Therapeutics is an authoritative, peer-reviewed journal published bimonthly in print and online that focuses on cutting-edge basic research, therapeutic applications, and drug development using nucleic acids or related compounds to alter gene expression. Nucleic Acid Therapeutics is the Official Journal of the Oligonucleotide Therapeutics Society. Complete tables of content and a free sample issue may be viewed on the Nucleic Acid Therapeutics website.

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Drug delivery strategy eliminates myotonia symptoms in mice with myotonic dystrophy

Part of the ancient mystery of the makeup of the modern Western dog has been solved by a team led by researchers at the University of California, Davis, School of Veterinary Medicine.

Several thousand years after dogs originated in the Middle East and Europe, some of them moved south with ancient farmers, distancing themselves from native wolf populations and developing a distinct genetic profile that is now reflected in todays canines.

These findings, based on the rate of genetic marker mutations in the dogs Y chromosome, supply the missing piece to the puzzle of when ancient dogs expanded from Southeast Asia. The study results are published online this month in the journal Molecular Biology and Evolution.

Our findings reconcile more than a decade of apparently contradictory archaeological and genetic findings on the geographic origins of the dogs, said Ben Sacks, lead study author and director of the Canid Diversity and Conservation Group in the Veterinary Genetics Laboratory at the UC Davis School of Veterinary Medicine.

Considerable archaeological evidence indicates that the first dogs appeared about 14,000 years ago in Europe and the Middle East, while dogs did not appear in Southeast Asia until about 7,000 years later. Scientists have been puzzled, though, because growing genetic evidence suggests that modern Western dogs, including modern European dogs, are derived from a Southeast Asian population of dogs that spread throughout the world.

The problem: If dogs originated in Europe, why does genetic evidence suggest that modern European dogs are originally from Southeast Asia? Sacks and his team think theyve found the answer.

Data from our study indicate that about 6,000 to 9,000 years ago, during what is known as the Neolithic age, ancient farmers brought dogs south of the Yangtze River, which runs west to east across what is now China, Sacks said.

While dogs in other parts of Eurasia continued to readily interbreed with wolves, the dogs that moved into Southeast Asia no longer lived near wolves, and so they developed a totally different evolutionary trajectory, influenced by the agriculture of Southeast Asia, he said. Those ancient dogs apparently underwent a significant evolutionary transformation in southern China that enabled them to demographically dominate and largely replace earlier western forms.

To calculate when the modern European and Southeast Asian dogs diverged, the researchers calculated the mutation rate of genetic markers on the Y chromosome in a sample of 100 Australian dingoes, a dog population known to have appeared about 4,200 years ago. Knowing the rate at which these genetic mutations occur, the researchers were able to backtrack through history and estimate the point when dogs of Eurasia and Southeast Asia parted company as being roughly 7,000 years ago.

So, in a sense, both of the original hypotheses are true: Dogs did originate in Europe and the Middle East, but modern dogs trace their ancestry most recently to the East and specifically Southeast Asia, Sacks said.

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Agriculture and parting from wolves shaped dog evolution, study finds

biology undiscovered: episode 4 - legos of life
hey 🙂 here #39;s a short commentary for our biology class. this episode focuses on the topic of the DNA and the concept of genetics and heredity. its not much, but we did our best. special thanks to mrs. mary jean sabanal for sharing her knowledge to us 🙂 all rights reserved: One-Natomy group; II- Aristotle PACITA COMPLEX NATIONAL HIGH SCHOOL

By: Seandale Rodrichson Vista

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biology undiscovered: episode 4 - legos of life - Video

breast implants choosing the right size breast implant
mybreastimplants.net.au Breast Implants -- Factors to Consider Before Deciding on Having Breast Implants Not all women are gifted with the right size of breasts they want. Some have smaller that the tendency is it cannot even be noticed while others may have as big as watermelon, that #39;s just a description made by men who are so much interested with big breasted women and also by women who are, well, insecure about the size of breast they have. Sizes of breast are actually genetics. Either way, no matter how hereditary the size of breast can be passed from one generation to generation, those who are not gifted with the size of breast they want can now be able to have exactly that. With all the developments that have been made in our generation, especially in the field of science and technology, enlarging breasts is one of the simplest tasks any doctors would be happy to perform on you. Breast enlargement or otherwise known as breast augmentation surgery is a surgical placement of breast implants to increase its fullness and its projection. This is the process or method cosmetic surgeons perform to produce the size of breast their clients desired. Before any women should decide on taking breast implant procedure, they should think about some few factors first. These factors include deciding about the size of breast implant depending on their body size, the size of breast that they find attractive, and the shape of the breast implant they want. The first factor is the ...

By: Gary Eldridge

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breast implants choosing the right size breast implant - Video

Gun Bros 2 - Universal - HD Gameplay Trailer
Gun Bros 2 by Glu Games Inc. Optimized for the iPhone 5 and iPad 3rd Gen 4th Gen. Gun Bros 2 does not support the iPhone 3GS, iPod Touch (4th generation) or iPad 1. Untold years after the first TOOL wars, the Tyrannical Oppressors Of Life have returned to finish the job. Only the Freakishly Rugged Advanced Genetics Galactic Enforcement Division (FRAGGED) agents Percy and Francis Gun stand in their way. Armed with a new array of highly advanced and ridiculously destructive weapons, the Gun Bros are once again defending the galaxy from the TOOL insurgency. It is a time to innovate and eradicate. The last conflict has left both sides scrambling to rebuild their armories. Old Xplodium mines have been reopened and even decommissioned factories are once again roaring to life as the conflict escalates. It is up to Percy and Francis to stop this threat from reemerging with an even more devastating arsenal of killing machines. The Gun Bros are back and, once again, responsible for defending the galaxy. Luckily, they #39;ve got access to a host of new gear that will help them defeat TOOL REAL-TIME MULTIPLAYER! Battle the TOOL hordes with your Gamecenter friends, head over to the all-new Endless Mode and check it out! NEW GUNS MODS! Choose from a broad range of weapons; from pistols rocket launchers to new and improved laser weapons shotguns. Collect MODS and strap them on your weapon to gain secondary, tertiary and even quaternary fire modes! Players can even unleash multiple ...

By: touchgameplay

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Gun Bros 2 - Universal - HD Gameplay Trailer - Video

DungeCraft: Feed the Beast - Automating Bees - S3 E35
DungeCraft: Feed the Beast - Automating Bees Welcome to another episode of DungeCraft, the minecraft Feed the Beast (FTB) multiplayer survival server running Direwolf20 modpack! In this episode I go over genetics for the first line of bees up to cultivated, and then show you how to automate your apiaries. Good bee links: forum.feed-the-beast.com damnedsky.blogspot.com http://www.minecraftforum.net feed-the-beast.wikia.com My world download link, FTB pack download, and questions can be found and asked all in this thread: http://www.minecraftforum.net DungeCraft is a whitelisted Feed the Beast (FTB) server for youtubers only. If you #39;re a youtuber, and you want to join the project read the thread above to see if you qualify. Server seed: DCSeason3Seed23 Extrabiomes disabled: Snowyforest, Snowyrainforest == Other tubers on the server == Andrewpunk: http://www.youtube.com TheLMNOSteve: http://www.youtube.com Max (Thunder_Funk): http://www.youtube.com SilentMystification (Dadrewster): http://www.youtube.com Pyrostasis: http://www.youtube.com Finbar: http://www.youtube.com == Connect with me! == DG.net forums: http://www.dungeonguru.net Twitch.tv livestream: http://www.twitch.tv Facebook: http://www.facebook.com Twitter: twitter.com Minecraft / Feed the Beast (FTB) is a sandbox building game where you build impressive things from a blank world. You can play minecraft solo or on a multiplayer server. For PC and XBOX.

By: dungeongurunet

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DungeCraft: Feed the Beast - Automating Bees - S3 E35 - Video

OMICS Group-Hereditary Genetics Current research-2161-1041-1-109
OMICS Group is an Open Access publication model that enables the dissemination of research articles to the global community. Thus, all articles published under Open Access can be accessed by anyone.

By: OMICSGroup I Articles

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OMICS Group-Hereditary Genetics Current research-2161-1041-1-109 - Video

Obama Pledges $3 Billion to Map the Brain
The Brain Activity Map project will cost about $3 billion. But we might benefit twenty times more! Anthony shows us where the future of brain science is headed. "Obama Seeking to Boost Study of Human Brain" http://www.nytimes.com "The Obama administration is planning a decade-long scientific effort to examine the workings of the human brain and build a comprehensive map of its activity, seeking to do for the brain what the Human Genome Project did for genetics." "The Brain Activity Map Project and the Challenge of Functional Connectomics" arep.med.harvard.edu "The function of neural circuits is an emergent property that arises from the coordinated activity of large numbers of neurons. To capture this, we propose launching a large-scale, international public effort, the Brain Activity Map Project, aimed at reconstructing the full record of neural activity across complete neural circuits." "OBAMA #39;S BRAIN" http://www.newyorker.com "What will Obama #39;s proposed investment in neuroscience look like? Few details have been announced." Brain Mind Institute: bmi.epfl.ch The Blue Brain Project bluebrain.epfl.ch "Are you maximizing your DNA potential?" http://www.themakingsofme.com Image Credit © John Lund/Blend Images/Corbis DNews is a show about the science of everyday life. We post two new videos every day of the week. Watch More http://www.youtube.com Subscribe http://www.youtube.com DNews Twitter twitter.com Anthony Carboni Twitter: twitter.com Laci Green Twitter twitter.com Trace Dominguez Twitter twitter.com ...

By: DNewsChannel

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Obama Pledges $3 Billion to Map the Brain - Video

Strainhunters Live Thread - Smoking with Donfrom DNA @ Spannabis 2013
First dab of the expo the first day with Don From DNA genetics, when it comes to extraction, you know those guys will have some of the best taste around 😉 Check the Full report pictures and videos on Strainhunters.com

By: strainhunterslive

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Strainhunters Live Thread - Smoking with Donfrom DNA @ Spannabis 2013 - Video

Genetics Video: Brain Cancer

By: Jed Olano

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Genetics Video: Brain Cancer - Video

Dr. Mark Green on Migraines and Genetics
Menstrual migraines, cluster headaches, basilar migraines, and tension-type headaches all can be debilitating, painful and difficult to diagnose, but the Mount Sinai Center for Headache and Pain Medicine is especially equipped with the latest technology and experience to provide diagnosis and treatment in even the most complicated cases. Treatment options include biofeedback, Botox, and other interventional procedures. Dr. Green considers all available options and medical alternatives to offer the highest level of medical treatment and care.

By: MountSinaiNY

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Dr. Mark Green on Migraines and Genetics - Video

Ponderosa Ridge Ranch Flip Red Bluff Bull Sale
Flip is an incredible dog.He sold at Red Bluff Bull Sale 2012 for $11500. He is a full litter mate to Zeke. These 2 dogs as well as the entire litter are a prime example of genetics at their finest!!

By: Tanya williams

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Ponderosa Ridge Ranch Flip Red Bluff Bull Sale - Video

Seconds to none- Animation with After Effects
hello everybody, this is a After Effects Animation that i have done together with my girl for the Design School Munich Bonus 2013 Project. i hope you like it. feel free to get in touch with me if you have any questions and pls check out my other videos 😉 Music by Savage Genetics (Silent Hill Remix) Directed by Marco Reinhardt and Jessica Drechsler All Rights Reserved http://www.facebook.com/eitelartworks

By: eiteldesign

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Seconds to none- Animation with After Effects - Video

Hair loss Encyclopedia
also increased over the last five years, #39; DM Mahajan, dermatologist at Delhi #39;s Apollo Hospital. The nature of hair problems is usually varied, from hair fall, thinning and baldness to dandruff and scalp problems. Depending on the age group, some problems are more common than others. #39;The most common problem that inflicts people across all age groups is hair loss. This is a big concern for women and young males. The second most common problem is dandruff. This is usually related to climate, type of water and soap and shampoo used, Concerns about hair loss are usually more in men and at a younger age, starting as early as in their 20s #39;, Mohan Thomas, cosmetic surgeon at Mumbai #39;s Breach Candy Hospital. The reason for hair loss could be anything -- bad lifestyle, poor diet, pollution, hormones or even genetics. But stress is the big culprit behind the increasing hair woes among people, doctors say.

By: bhaskban

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WebMD News from HealthDay

By Amy Norton

HealthDay Reporter

THURSDAY, Feb. 21 (HealthDay News) -- When it comes to treating heart failure, the ultimate hope is to develop a therapy that repairs the damaged heart muscle.

Now, an early study hints at a way to do that by harnessing the body's natural capacity for repair.

Heart failure is a chronic, progressive condition where the heart cannot pump blood efficiently enough to meet the body's needs, which leads to problems like fatigue, breathlessness and swelling in the legs and feet. Most often, it arises after a heart attack leaves heart muscle damaged and scarred.

In the new study, researchers were able to use gene therapy to modestly improve symptoms in 17 patients with stage III heart failure -- where the disease is advanced enough that even routine daily tasks become difficult.

What is novel about the tactic, the researchers said, is that the gene therapy is designed to attract the body's own stem cells to the part of the heart muscle that's damaged. The hope is that the stem cells will then get some repair work done.

The findings, published Feb. 21 in the journal Circulation Research, are preliminary, and much more research needs to be done.

"This is a proof-of-concept study," explained lead researcher Dr. Marc Penn, a professor at Northeast Ohio Medical University in Rootstown, and director of research at Summa Cardiovascular Institute in Akron. But Penn and other heart failure experts said they were cautiously optimistic about the therapy's potential for at least some patients.

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Gene Therapy Shows Early Promise for Heart Failure