Archive for the ‘Gene Therapy Research’ Category

By Serena Gordon HealthDay Reporter

THURSDAY, Feb. 14 (HealthDay News) -- In news that might one day help humans who struggle with type 1 diabetes every day, Spanish researchers report that a single session of gene therapy injections cured five beagle puppies who had the blood sugar disease.

Even four years later, the dogs showed no signs of diabetes.

"Our data represent the first demonstration of long-term correction of diabetes in a large animal model using gene transfer," the scientists wrote in the Feb. 7 online issue of Diabetes.

However, the dogs all had a chemically induced version of diabetes that's meant to model human type 1 diabetes.

In humans, type 1 diabetes is an autoimmune disease, which means the body's own immune system mistakenly attacks healthy cells as though they were bacteria or viruses.

In the case of type 1 diabetes, the immune system destroys the insulin-producing beta cells located in the pancreas. Insulin is a hormone that's needed to transport glucose into the body's cells to be used as fuel. Glucose is sugar that comes from the carbohydrates you consume. Carbohydrates are nutrients found in a variety of foods, including fruits, vegetables, breads and sweets.

Once the beta cells are destroyed, the body no longer makes insulin (or makes very little of the hormone), and anyone with type 1 diabetes needs insulin injections or an insulin pump for the rest of their lives.

However, insulin needs change constantly, depending on the type and amount of food eaten and level of physical activity. Even emotions can affect insulin levels. Too little insulin can cause high blood sugar levels, while too much insulin can cause low blood sugar levels. Neither condition is healthy and, if severe enough, either can cause death.

In the current study, the researchers developed a gene therapy that served two purposes: one was to sense the amount of glucose in skeletal muscles and the other was to release insulin. This research group had already tested this therapy in mice, where it was found to be successful in controlling blood sugar levels.

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Lucky Dogs Get Shot at Diabetes Cure

Prof Claude C Tanouji at BIOTEC part 1
Nobel Laureate for Physics Prof. Claude C. Tannoudji #39;s keynote speech and dialogue "Manipulating atoms with light : Review of a few promising applications" on Wednesday, December 8, 200 at Thailand Science Park co-hosted by the National Genetic Engineering and Biotechnology Center of the Ministry of Science and Technology

By: PeaceFoundationNET

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Prof Claude C Tanouji at BIOTEC part 1 - Video

Prof Claude C Tanouji at BIOTEC part 2
Nobel Laureate for Physics Prof. Claude C. Tannoudji #39;s keynote speech and dialogue "Manipulating atoms with light : Review of a few promising applications" on Wednesday, December 8, 200 at Thailand Science Park co-hosted by the National Genetic Engineering and Biotechnology Center of the Ministry of Science and Technology

By: PeaceFoundationNET

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Prof Claude C Tanouji at BIOTEC part 2 - Video

Prof. Claude C. Tannoudji at BIOTEC
Nobel Laureate for Physics Prof. Claude C. Tannoudji #39;s keynote speech and dialogue "Manipulating atoms with light : Review of a few promising applications" on Wednesday, December 8, 200 at Thailand Science Park co-hosted by the National Genetic Engineering and Biotechnology Center of the Ministry of Science and Technology

By: PeaceFoundationNET

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Prof. Claude C. Tannoudji at BIOTEC - Video

Foods, Diet and Nutrition: Nutrient Density Pesticides and Genetically Engineered Foods
Arden B. Anderson, DO, Ph.D., MSPH presents a compelling presentation at the "12th Clinical Applications for Age Management Medicine Conference" May 2012, Hollywood, FL Foods, Diet and Nutrition: What a Clinician Needs to Know About Nutrient Density, Pesticides and Genetically Engineered Foods Arden B. Anderson, DO, Ph.D., MSPH Medical Director, Crossroads Healing Arts, Goshen, IN Professional Food Production Consultant / Author / Instructor Lecture objectives: bull; Describe the link between soil health and human health bull; Explain how genetic engineering of foods creates a snowball effect of health decline, nutrient deficiency and disease expansion in human and animal consumers

By: AgeManagmentMedicine

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Foods, Diet and Nutrition: Nutrient Density Pesticides and Genetically Engineered Foods - Video

The Sandy Hook Village and Children of the Damned Theory
This video is a speculative journey into an evolving theory involving the Sandy Hook shooting incident and the many residents and officials of Sandy Hook and the Newtown area. If the Super Bowl black out and the Christopher Dorner affair not been more pressing at the time, I would have continued in a Sandy Hook discussion about the odd and strangeness of the people of Newtown and Sandy Hook. Now that I am transitioning to the Pope, I wanted to provide this report to help finish out some Sandy Hook thoughts. While I am the first to realize that I cannot prove any of what I speculate about, there are times in any conspiracy when we run into a wall or when we think we can learn no more. If however; there are unanswered questions, then at times like this, I am the first to step outside of the box and look for more fantastic reasons and or motivations. This video is in no way a concise, historical or investigative effort, it is but a theory that brings together the many elements of Sandy Hook and attempts to connect them with what binds the whole group to silence and a loyalty to something unseen. I am discussing what I think and why I think it. Since I only present what I offer with no expectation of your belief or acceptance, I do hope that if you are one of those that has been puzzled why the people of Newtown and Sandy Hook could be so odd, well then, have I got a theory for you. I am also in no way claiming that all of the residents and or children of Sandy Hook are part ...

By: MrCati

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The Sandy Hook Village and Children of the Damned Theory - Video

How to lose fat without losing muscle | How to cut properly
Cutting is one of the hardest aspects of bodybuilding. It is very tough to lose fat and try and maintain the muscle you gained on your bulk, and at the same time stay motivated while seeing results come very slowly. I have recently completed a cut, and I only did it simply just to see what my physique looks like at a low bodyfat percentage. In particular I found that I need to work on my lower lats, my forearms, and the back of my legs (hamstrings and calves). Some positive things I found after I cut was that my chest turned out great and looks big and has a nice shape to it (thank you genetics) and my arms turned out pretty well too, having good definition and relatively good size (17.25 inches pumped) my quads turned out well and my upper back looks good also. In this quick video I #39;ll share my cutting experience and what I learned from it. Please like, comment and subscribe for more great informative videos and I #39;ll be sure to have a posing video out very soon 🙂

By: RippedAndJacked

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How to lose fat without losing muscle | How to cut properly - Video

Blueberry Buds (Outdoor) Unknown Genetics
These Blueberry Buds are outdoor grown, not really sure what the genetics are but buds are nice and smells great. Taste is very sweet I give it a rating of 6/10.

By: kay G

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Blueberry Buds (Outdoor) Unknown Genetics - Video

Tik Tok Genetics Bloopers
Note: Do not own music We failed at rapping and singing but hey we got an A on it Starring Big Black and Mac Attack feat. Mix Master Reese #39;s Puffs Lyrics: Wake up in the morning feeling like meiosis Got diploid cells, need some haploids This process aint mitosis (Fo shizzle) Because I need more gametes, with half the chromosomes Cause when I reproduce tonight, my gametes wont be alone Im talking - ova and some sperm, sperm When youre sexually mature, -ure A zygote is what you earn, earn You know it, got my favorite mate, mate Before I procreate, ate Trying to have a baby... So just reproduce Gametes, come on, keep it loose Its a fight, get it right Gotta pass on genes tonight Thats sex, its success When your children pass on your chromosomes Chromosomes You know success Depends on sex Meiosis means Lots of babies With mixed up genes Were all unique That #39;s why we need All our gametesx3 We got that sister chromtid My personality is heredity We make offspring by fertilization Recessive genetics are not dominant Chromosome Chromosome Chromosome Chromosome Chromosome Chromosome

By: maccers2196

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Tik Tok Genetics Bloopers - Video

Incipit of Middlesex by Jeffrey Eugenides - Incipit di Middlesex di Jeffrey Eugenides
Middlesex is a Pulitzer Prize-winning novel by Jeffrey Eugenides published in 2002. " So begins Jeffrey Eugenides #39;s second novel, Middlesex, the story of Calliope Stephanides, who discovers at the age of 14 that she is really a he. Cal traces the story of his transformation and the genetic condition that caused it back to his paternal grandparents, who happen also to be brother and sister, and the Greek village of Bithynios in Asia Minor. In 1922, Desdemona Stephanides and her brother, Lefty, whose parents were killed in the recent war with the Turks, are living alone in their nearly abandoned village. Pulled together by isolation, sympathy, and, perhaps, fate, Lefty and Desdemona become husband and wife, and a recessive genetic condition begins its journey toward eventual expression in their grandchild Calliope. Middlesex is a story about what it means to occupy the complex and unnamed middle ground between male and female, Greek and American, past and present. For Cal, caught between these identities, the journey to adulthood is particularly fraught. Jeffrey Eugenides #39;s epic portrayal of Cal #39;s struggle is classical in its structure and scope and contemporary in its content mdash;a tender and honest examination of a battle that is increasingly relevant to us all. Trad. Italiana del incipit : Sono nato due volte : bambina, la prima, un giorno di gennaio del 1960 in una Detroit straordinariamente priva di smog , e maschio adolescente, la seconda, nell #39;agosto 1974, al pronto ...

By: NinotchkaAndMe

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Incipit of Middlesex by Jeffrey Eugenides - Incipit di Middlesex di Jeffrey Eugenides - Video

High-Quality Organic Wheat and Ancient Grain Production
To take advantage of the rapidly growing market for locally grown modern and heritage wheat and the specialty grains emmer, spelt, and einkorn, farmers must meet buyers #39; expectations for high quality. Researchers from the NIFA OREI project Value-added grains for local and regional food systems will overview grain quality indicators and discuss critical steps in producing high-quality grain mdash;from sourcing appropriate seed through planting and harvesting practices to seed-cleaning, dehulling, and storage. This webinar is for farmers, ag professionals, grain buyers and processors, and others seeking to optimize grain quality. While focused on production in the Northeast, many of the management practices discussed will be applicable to other regions of the country. This webinar was recorded on February 12, 2013. David Benscher is a Research Support Specialist in the Small Grains Breeding Program, Department of Plant Breeding Genetics, Cornell University. For the last 16 years, he has been managing the field research portion of the program and varietal trials for spring and fall planted grains under conventional practices. Most recently, he has been trialing heritage wheat and ancient grains under organic practices. Greg Roth is a professor of agronomy at Penn State University where he works on grain crops research and extension and focuses on management of grain crops like corn, wheat, barley and soybeans to improve the yield, quality, and value in the marketplace. Elizabeth ...

By: eOrganic

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High-Quality Organic Wheat and Ancient Grain Production - Video

Taimur Khan Introduces #39;The Flying Pigeon #39; Written By Ikhalq Ahmad Khan
QUALIFICATIONS: i) M. Sc. ( Botany), ii) B.Sc.(Forestry) iii) 100 Credit Courses each in Genetics and Plant Breeding at the University of Minnesota, USA. iv) A 3-month Forestry Research Course at the Common Wealth Forestry Institute, Oxford, UK. v) A 3-month Forestry Research Course at the Washington State University, USA. EXPERIENCE: Over 60 years of uninterrupted Pigeon Fancy. Have taken part in annual Flying Competitions since 1973 and have won scores of Cups and Shields. PRESIDENTSHIPS: i) Punjab Flying Tipplers, Club, Lahore since 1973. ii) Pakistan Racing and Show Pigeons Association since 1995. iii) Hakim Shehzada Daff, the oldest and biggest Party of Lahore Fanciers. Acted as MODERATOR for the defunct TIPPLER TOPPICS, an international Forum. I am the CHIEF MODERATOR for the prestigious and biggest Pigeon Forum, the Pakistan Pigeons. I am a MEMBER of AUSSIETIPPLERS, TIPPLERS-CHAT and some other International Forums. I am not only utilising my knowledge and experience for myself but am extending it to help hundreds of Fanciers all over Pakistan and rest of the World including India, Middle East, Europe. North America, etc.

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Taimur Khan Introduces 'The Flying Pigeon' Written By Ikhalq Ahmad Khan - Video

Public Lecture with Roger Leakey: Living with the trees of life.
Roger Leakey was Professor of Agroecology and Sustainable Development of the James Cook University, in Cairns, Australia (2001-2006); Head of Tropical Ecology at the Centre for Ecology and Hydrology in Edinburgh, UK (1997-2001) and Director of Research at the International Centre for Research in Agroforestry (now the World Agroforestry Centre 1993-1997). Currently he is Vice Chairman of the International Tree Foundation, a UK registered charity and Vice President of the International Society of Tropical Foresters. He was born in Kenya and educated at Marlborough College in England before becoming an agriculturalist (NDA and CDA from Seale Hayne Agricultural College (1964-67 including 18 months practical farm work in England, Sweden and Scotland); B.Sc. Hons. in Agricultural Botany (University of Wales 1967-1970), Ph.D. in the physiology of perennial weeds while working at the ARC Weed Research Organization (University of Reading 1970-1974). He was awarded a D.Sc. by the University of Wales in 1998 for his research on the domestication of tropical trees, working at the interface of many disciplines (agronomy, plant physiology, genetics, ecology, forestry, horticulture, social science, food science). He holds fellowships from the Institute of Biology (FIBiol, CBiol), Royal Geographical Society (FRGS), Edinburgh University Faculty of Science, and the World Agroforestry Centre. Between 2006 and 2008, he was a Coordinating Lead Author in the International Assessment of ...

By: zefbonn

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Public Lecture with Roger Leakey: Living with the trees of life. - Video

Mobile Upload 28 - YHWH #39;s GENETICS WAR
This video was uploaded from an Android phone. UFO playlist: http://www.youtube.com

By: endtimes777

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Mobile Upload 28 - YHWH's GENETICS WAR - Video

Dihybrid Crosses
Genetics: Dihybrid Crosses

By: mrtimothyteacher

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Dihybrid Crosses - Video

567
567 Deep South Rodeo Genetics

By: Summerrain411

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567 - Video

Fish Genetics Promo
Sample Video of Fish Genetics online course

By: crwphotography1

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Fish Genetics Promo - Video

Davinci #39;s Last Supper Painting Is Copied Off Biotto Painting Betrayal Kiss Of Judas
Through my ongoing paranomal experience-encounter I discovered that Davinci #39;s Last Supper Painting which I discovered is genetic blueprint to the bridging, manipulation, and contamination of mankinds genetics is a spin off of Biotto #39;s 1304-06 Painting at the Scrovehi Chapel. Both paintings have remarkable encrpytion styles which both factually conclude that both artist enjoyed a higher knowledge as to manskind true origins, genetic alterings, and controlledgenetic evolution.

By: Geroneification

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Davinci's Last Supper Painting Is Copied Off Biotto Painting Betrayal Kiss Of Judas - Video

Diabetes Cured In Dogs
Researchers at the University of Barcelona have succeeded in completely curing type 1 diabetes in dogs with a single session of gene therapy. This is the first time that the disease has been cured in large animals, a fundamental step towards applying the therapy in humans. The study, based on introducing a "glucose sensor" into muscle, has been published in the journal Diabetes. Video courtesy of the University of Barcelona. For complete story: http://www.33rdsquare.com

By: 33rdSquareVideos

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Diabetes Cured In Dogs - Video

Mitchell Joachim: Ecological Future Cities
On what would you base the city centers of tomorrow? Religion and churches or capitalism and skyscrapers? Hear innovator Mitchell Joachim share his predictions and the role genetic engineering and synthetic biology will play in the urban communities of the future. About Chicago Ideas Week Chicago Ideas Week is an annual seven-day celebration of ideas, innovation and community, aiming to become the platform for ideas, created for innovators, thinkers, doers. CIW #39;s goal is to stimulate new initiatives and ventures, create new connections and collaborations, and establish a community of people who have the desire to achieve great things. Learn more: http://www.chicagoideas.com

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Mitchell Joachim: Ecological Future Cities - Video

Andrew Hessel: The Next #39;IT #39; Industry: Biology
What lies at the intersection of genetic engineering and computing? Andrew Hessel has spent his career exploring that intersection with some amazing results -- hear why biology is the next "IT" industry and genetic engineering is for everyone. About Chicago Ideas Week Chicago Ideas Week is an annual seven-day celebration of ideas, innovation and community, aiming to become the platform for ideas, created for innovators, thinkers, doers. CIW #39;s goal is to stimulate new initiatives and ventures, create new connections and collaborations, and establish a community of people who have the desire to achieve great things. Learn more: http://www.chicagoideas.com

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Andrew Hessel: The Next 'IT' Industry: Biology - Video

ARTICULATE - Prometheus Engineer Suit
The Engineers, also called Pilots, Space Jockeys, Ossians or Mala #39;kak, are an ancient extraterrestrial species of unknown origin. They possess among the most advanced technology in the galaxy, this has made them masters of genetic engineering, such as seeding many primordial celestial bodies with life. The name "Engineer" was given by Elizabeth Shaw and Charles Holloway due to the lifeform being responsible for "engineering" the human race. Before the release of Prometheus, the Engineers were originally dubbed as the "Space Jockeys". The nickname was attached to it during production on Alien. Scott has stated he has no idea who christened the creature. People needed something to call this creature, and somehow Space Jockey stuck. But the creature has also had a host of other names including The Pilot (Giger #39;s original nickname for it), Pilots, James Cameron called it the "Big Dental Patient," and later in the novel Aliens: Original Sin as Mala #39;kaks. Their "scientific" name is "Mundus gubernavi" (Universal Pilot). The Engineers are extremely pale-white, hairless and humanoid due to their subterranean nature, with two arms and legs, and said to have staring, "dead seeming" eyes. The veins underneath their skin are visible, and their pupils are in the shape of oblong plus-symbols. The Engineers are 7 feet tall and breathe oxygen just like human beings but are also able to survive on LV-223 prime;s surface. Though not much is known about the Engineers, it is shown that the ...

By: Sean loke

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ARTICULATE - Prometheus Engineer Suit - Video

[ Video 1 ] | [ Video 2 ]

Alan McStravick for redOrbit.com Your Universe Online

The mammalian retina is a masterful example of genetic engineering. Each moment our eyes are open, we take in mountains and mountains of data that has to be pored over, interpreted and processed by a specific cortical region within our brains. Despite their seemingly endless capabilities, even our retinas have their limits. That is, until today, with the release of a new study by researchers led by Duke University neurobiologist Miguel Nicolelis. In their study, the team was able to give laboratory rats the ability to touch infrared light. Infrared light is typically invisible to mammalian retinas.

A professor of neurobiology, biomedical engineering, and psychology and neuroscience, Nicolelis is also the co-director of the Center for Neuroengineering. Assisting him with his study were Eric Thomson and Rafael Carra. Thomson is a post-doctoral research associate. Carra, visiting from the University of Sao Paulo in Brazil, is studying medicine in his home country. Grant support for the study was provided by the National Institutes of Health.

The rats were able to detect the infrared light after the team fitted them with an infrared detector that was wired to microscopic electrodes implanted in the part of the mammalian brain that processes tactile information. It was the connection to this region of the brain responsible for the sense of touch that, at first, made the initial interaction with the infrared beam feel as though it was touching the rat subjects.

Another first celebrated by this study demonstrated how, for the first time, a sensory input could be implanted into a cortical region specialized for reception of information involving another of our senses, altogether without actually hijacking the region for the newly chosen function. According to Nicolelis, the suggestion made by this discovery is that if an individuals visual cortex were damaged, negating their ability to see, it might now be possible to aid in their regaining the sense of sight by implanting a neuroprosthesis in another cortical region.

In Search of Infrared Vision

The initial experiments with the laboratory rats were conducted to determine whether or not they could even detect infrared light. Team leader Nicolelis has claimed, however, he sees no reason why, in the future, animals couldnt be given full-fledged infrared vision. In fact, with the use of a neuroprosthesis, there is no reason why animals and humans couldnt be given the ability to see in any region of the electromagnetic spectrum.

Nicolelis even believes we might one day be able to see magnetic fields.

We could create devices sensitive to any physical energy. It could be magnetic fields, radio waves or ultrasound. We chose infrared initially because it didnt interfere with our electrophysiological recordings, he said.

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Brain-Machine Interface Allows Rat To 'Touch' Infrared Light

Synthetic DNA can perform logic operations such as NAND and give out the answer by lighting up the cell with green fluorescent protein, or GFP.

Ref. 1

Synthetic biologists have developed DNA modules that perform logic operations in living cells. These genetic circuits could be used to track key moments in a cells life or, at the flick of a chemical switch, change a cells fate, the researchers say. Their results are described this week in Nature Biotechnology1.

Synthetic biology seeks to bring concepts from electronic engineering to cell biology, treating gene functions as components in a circuit. To that end, researchers at the Massachusetts Institute of Technology (MIT) in Cambridge have devised a set of simple genetic modules that respond to inputs much like the Boolean logic gates used in computers.

These developments will more readily enable one to create programmable cells with decision-making capabilities for a variety of applications, says James Collins, a synthetic biologist at Boston University in Massachusetts who was not involved in the study.

Collins developed the genetic toggle switch that helped to kick-start the field of synthetic biology more than a decade ago2. A wide range of computational circuits for cells have been developed since, including a simple counter that Collins and his team devised in 20093.

But to make this a really rigorous engineering discipline, we need to move towards frameworks that allow you to program cells in a more scalable fashion, says Timothy Lu, a synthetic biologist at MIT who led the latest research. We wanted to show you can assemble a bunch of simple parts in a very easy fashion to give you many types of logical functions.

Lus logic modules are based on plasmids, circular strings of DNA, that are inserted into Escherichia coli cells. He and his colleagues devised 16 plasmids one for each of the binary logic functions allowable in computation. Each variant comprises promoter and terminator DNA sequences, which start or halt gene transcription, and an output gene that encodes a green fluorescent protein.

The key to the system is the use of recombinase enzymes, which cut and rearrange promoter and terminator DNA sequences to turn them on or off. In other words, recombinase enzymes are the inputs that determine whether the output gene is transcribed.

An electronic AND gate, for example, gives a positive output only when voltage is applied to both of its inputs. In the genetic version, the output gene is transcribed only when both terminator sequences between it and the promoter sequence are neutralized by two inputs in the form of recombinase enzymes.

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How to turn living cells into computers

Public release date: 12-Feb-2013 [ | E-mail | Share ]

Contact: Vicki Cohn vcohn@liebertpub.com 914-740-2100 Mary Ann Liebert, Inc./Genetic Engineering News

New Rochelle, NY, February 12, 2013About 1 in 150 children are affected by an autism spectrum disorder (ASD), a group of neurodevelopmental disorders characterized by difficulty with language, communication, and social interaction. A critical review of several published studies evaluating the potential for therapy or assistance dogs to help children with ASD overcome some of these challenges is published in The Journal of Alternative and Complementary Medicine, a peer-reviewed journal from Mary Ann Liebert, Inc., publishers. The article is available free on the Journal website at http://www.liebertpub.com/acm.

Interactions with therapy dogs, or the introduction of an assistance dog into a household with a child who has an ASD, may help the child develop emotional attachments and interaction in a social setting based on simple and predictable patterns, without having to interpret verbal cues. The enhanced capability for social interaction they would achieve may then carry over to interpersonal communication and relationships.

In the article "Use of Assistance and Therapy Dogs for Children with Autism Spectrum Disorders: A Critical Review of the Current Evidence," Alessandra Berry, PhD and coauthors from Istituto Superiore di Sanit, Rome, Italy, describe the body of published study results as encouraging. They emphasize the need for larger, better designed studies in the future to confirm and build on these findings.

###

About the Journal

The Journal of Alternative and Complementary Medicine is a monthly peer-reviewed journal publishing observational, clinical, and scientific reports and commentary intended to help healthcare professionals and scientists evaluate and integrate therapies into patient care protocols and research strategies. Complete tables of content and a sample issue may be viewed on the Journal website at http://www.liebertpub.com/acm.

About the Publisher

Mary Ann Liebert, Inc., publishers is a privately, held, fully integrated media company known for establishing authoritative peer-reviewed journals in many promising areas of science and biomedical research, including Alternative and Complementary Therapies, Medical Acupuncture, and Journal of Medicinal Food. Its biotechnology trade magazine, Genetic Engineering & Biotechnology News (GEN), was the first in its field and is today the industry's most widely read publication worldwide. A complete list of the firm's 70 journals, books, and newsmagazines is available on the Mary Ann Liebert, Inc., publishers website at http://www.liebertpub.com.

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Can therapy dogs be beneficial for children with autism spectrum disorder?