Archive for the ‘Gene Therapy Research’ Category

Akaushi bred for healthy marbling
The Akaushi breed, which is known for exceptional marbling, is relatively new to the United States. At the National Western Stock Show, Bubba Bain, executive director for the American Akaushi Association describes the breed #39;s attributes and how commercial producers are using Akaushi genetics in crossbreeding programs.

By: CattleNetwork

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Akaushi bred for healthy marbling - Video

Teleseminar Announcement - Rise In Love and Abundance Riding The Eternal Cycle of Creation
February 23, 2013 is the day when we start the 4 part teleseminar series accessible to registered multiversity students of the Genetics Of Divinity, where the following topics will be covered : 1. Understand the Cycle Of Creation as defined by the Genetics Of Divinity 2. Understand the TRUE Law of Attraction and why it appears to be dysfunctional 3. Learn never before revealed information about the function of the 6 pairs of Human DNA and their role to define the life experience 4. Learn about brainwaves and their role to define the life experience 5. Learn to cleanse out physical and neuro-toxins to re-charge the DNA 6. Learn about Parallel Universes and define a life experience in them 7. Set specific targets of desire and how to leverage the Cycle of Creation to manifest those desires in the life experience. 8. Learn how to make the process of manifestation of logical and ethically feasible desires consistently repeatable If you want to attend this first of its kind teleseminar, please visit multiversity.info and click on the Register tab to complete the registration formalities

By: Joy Ghosh

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Teleseminar Announcement - Rise In Love and Abundance Riding The Eternal Cycle of Creation - Video

ANNUNAKI DREAMZ
I do believe they Created the DINOSAURS, they LOVE playing with GENETICS, and also they were very Good in DnA manipulation.

By: Tuna Dave

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ANNUNAKI DREAMZ - Video

Double stranded break repair model
For more information, log on to- shomusbiology.weebly.com Download the study materials here- shomusbiology.weebly.com In genetics, the initial processes involved in repair of a double-strand break by synthesis-dependent strand annealing (SDSA) are identical to those in the double Holliday junction model, and have been most extensively studied in yeast species Saccharomyces cerevisiae. Following a double-stranded break, a protein complex (MRX) binds to either end of the break, working with DNA nucleases to carry out resection, resulting in 5 #39; end digest to produce 3 #39; overhangs of single-stranded DNA. These overhangs are then bound to form a nucleoprotein filament, which can then locate DNA sequences similar to one of the 3 #39; overhangs, initiating a single-stranded strand invasion into the DNA duplex containing these sequences. Once strand invasion has occurred, a displacement loop, or D-loop, is formed, at which point either SDSA or a double Holliday junction occurs.[1] Homologous recombination via the SDSA pathway occurs in both mitotic and meiotic cells as an important mechanism of non-crossover recombination, and was first suggested as a model in 1976,[2] acquiring its current name in 1994.[3] As the double Holliday junction model was the first posited in order to explain this phenomenon,[4] various versions of the SDSA model were later proposed to explain heteroduplex DNA configurations that did not match predictions of the double Holliday junction model. Studies in S ...

By: Suman Bhattacharjee

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Double stranded break repair model - Video

Mechanism of competence generation
For more information, log on to- shomusbiology.weebly.com Download the study materials here- shomusbiology.weebly.com In microbiology, genetics, cell biology and molecular biology, competence is the ability of a cell to take up extracellular ("naked") DNA from its environment. Competence may be differentiated between natural competence, a genetically specified ability of bacteria which is thought to occur under natural conditions as well as in the laboratory, and induced or artificial competence, which arises when cells in laboratory cultures are treated to make them transiently permeable to DNA. This article primarily deals with natural competence in bacteria. Information about artificial competence is provided in the article Transformation (genetics). In the natural world DNA usually becomes available by death and lysis of other cells, but in the laboratory it is provided by the researcher, often as a genetically engineered fragment or plasmid. During uptake, DNA is transported across the cell membrane(s), and the cell wall if one is present. Once the DNA is inside the cell it may be degraded to nucleotides, which are reused for DNA replication and other metabolic functions. Alternatively it may be recombined into the cell #39;s genome by its DNA repair enzymes. If this recombination changes the cell #39;s genotype the cell is said to have been transformed. Artificial competence and transformation are used as research tools in many organisms (see Transformation (genetics)).[1 ...

By: Suman Bhattacharjee

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Mechanism of competence generation - Video

Forestry and Forest Industries 1946 Vocational Guidance Films
more at quickfound.net "Forest rangers at work and people engaged in harvesting, processing, and distributing forest products." Public domain film from the Prelinger Archive, slightly cropped to remove uneven edges, with the aspect ratio corrected, and mild video noise reduction applied. The soundtrack was also processed with volume normalization, noise reduction, clipping reduction, and/or equalization (the resulting sound, though not perfect, is far less noisy than the original). creativecommons.org en.wikipedia.org Forestry is the science, art, and craft of creating, managing, using, conserving, and repairing forests and associated resources in a sustainable manner to meet desired goals, needs, and values for human benefit. Forestry is practiced in plantations and natural stands. The main goal of forestry is to create and implement systems that allows forests to continue a sustainable provision of environmental supplies and services. The challenge of forestry is to create systems that are socially accepted while sustaining the resource and any other resources that might be affected. Silviculture, a related science, involves the growing and tending of trees and forests. Modern forestry generally embraces a broad range of concerns, including assisting forests to provide timber as raw material for wood products, wildlife habitat, natural water quality management, recreation, landscape and community protection, employment, aesthetically appealing landscapes, biodiversity ...

By: Jeff Quitney

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Forestry and Forest Industries 1946 Vocational Guidance Films - Video

Forearm Workouts | Palms Down Wrist Curls
Forearm workouts are essential to making the forearms grow especially if you don #39;t have naturally well developed forearms like I do. Doing the seated palms down wrist curl will help develop the forearms, especially top of them, the extensor muscles. Forearm exercises can only help you reach the physique that you want. If you do have good genetics for the forearms, it would still help to do exercises to make them look even bigger. http://www.rippedandjacked.com http

By: RippedAndJacked

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Forearm Workouts | Palms Down Wrist Curls - Video

DNA Transcription and Translation
The DNA is transcribed to RNA and RNA is translated to an amino acid sequence. This is the dogma of genetics.

By: mrphysh

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DNA Transcription and Translation - Video

Blue Dawg Star Haze - Titan Genetics Test Grow Ep. 5
Hey guys... just a little update vid on the Titan Genetics. 10/10 Star Haze are up thru the soil and 8/9 Blue Dawgs are up thru the soil. We got a couple stragglers but they should be up thru the soil in no time.

By: PNWGardenOfFunk

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Blue Dawg

Ophthalmology: Gene Therapy Research -- Katherine Wert, MS
Katherine Wert, Ph.D. Candidate at the Columbia University College of Physicians and Surgeons, discusses the role that gene therapy will play in the future to help patients suffering from eye disorders.

By: newyorkpresbyterian

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Ophthalmology: Gene Therapy Research -- Katherine Wert, MS - Video

Ophthalmology: Gene Therapy Clinical Trials -- Katherine Wert, MS
Katherine Wert, Ph.D. Candidate at the Columbia University College of Physicians and Surgeons, discusses the gene therapy clinical trials being run at NewYork-Presbyterian.

By: newyorkpresbyterian

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Ophthalmology: Gene Therapy Clinical Trials -- Katherine Wert, MS - Video

GE Free NZ is calling for intervention by the new Minister of Food Safety, Nikki Kaye, to direct the Food Standards Authority (FSANZ) to halt its assessment of a new GE soybean resistant to three herbicides, RoundUp, glufosinate and 2,4-D.

The latest scientific discovery of possible unexpected genetic consequences in GE crops being sold already has cast an even darker shadow over the flawed approval process for GE foods. The new 2,4-D-resistant crop (application A1073), must be kept out of the food chain.

The new research just published has detected an overlap of the introduced transgenic gene construct into an active viral region (Gene VI). This has the potential to seriously harm those who eat the foods containing this engineered event. Viral genes invade their host by disabling the protective defence of a cell to incorporate their infectious genes, and some plant viruses have similarities to those that affect humans)

The European Food Safety Authority has been alerted to the viral gene overlap that is a product of the genetic engineering process. Gene VI was found to be in 54 of the 86 GE/transgenic crops, which also contain a gene from the Cauliflower Mosaic virus (CaMV35S) gene to make a crop resistant to the RoundUp herbicide.

The call for intervention by the new Minister follows the failure to act by former Minister Kate Wilkinson when she held the food safety portfolio in cabinet.

"This is extremely concerning as the public rely on the purported expertise of food regulatory bodies," said Claire Bleakley president of GE Free NZ.

In September 2012, a paper by Professor Seralini and colleagues reported that there were serious deleterious effects including organ damage and tumour development in rats fed on GE corn that contained the CaMV 35S gene (Monsantos NK603).

There are few studies to monitor the effects of GE food when eaten. There are no diagnostic tools for health practitioners, no post-monitoring has ever been done and labelling of products is inadequate. This is in the context of a rising epidemic of digestive related cancers and illnesses with no as-yet identified cause.

"It is no good relying on industry studies: science must be unbiased and on the side of the public health. Those who are assessing GE food must be trained on the complex risks of GE/transgenic food and must stop dismissing all studies that go against the data supplied by industry," said Claire Bleakley.

"It is time that our Food Standards Authority (FSANZ) required rigorous long term feeding studies and assessed applications using independent published science rather than unpublished industry opinions," said Jon Carapiet, national spokesman for GE-Free NZ in food and environment.

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Intervention urged after viral gene found in GE crops

Newswise ANN ARBOR, Mich. University of Michigan research sheds new light on why certain people are more likely to suffer from rheumatoid arthritis paving the way to explore new treatments for both arthritis and other autoimmune diseases.

The new UMHS research in mice identifies how a specific group of genes works behind the scenes to activate the bone-destroying cells that cause severe rheumatoid arthritis, a debilitating health issue for millions of Americans.

We believe this could be a significant breakthrough in our understanding of why certain genes are associated with higher risk of rheumatoid arthritis and other autoimmune diseases a link that has been a mystery in the field for decades, says lead author Joseph Holoshitz, M.D., professor of internal medicine and associate chief of research in the division of rheumatology at the U-M School of Medicine.

We hope that this improved understanding will open the door to future design of drugs to treat this crippling disease and autoimmune disease in general.

The research appeared in The Journal of Immunology and was highlighted by Nature Reviews Rheumatology.

Rheumatoid arthritis is a chronic inflammatory disorder that damages the lining of joints and causes bone erosion, joint deformity and disability. The disease is an autoimmune disorder, characterized by the bodys immune system mistakenly attacking the body's tissues.

Researchers have long studied the phenomenon of why certain versions of an inherited group of genes known as human leukocyte antigen (HLA) are associated with autoimmune disorders. One subset of these HLA genes that codes a protein sequence called shared epitope represents the most significant genetic risk factor for rheumatoid arthritis, affecting disease susceptibility and severity. However, until now, the reason for this strong link has been unclear.

A common theory in the field has been that the association between particular HLA genes and autoimmune diseases is a result of mistakenly identifying body tissues as foreign making the body the target of the immune system and setting off an attack on self-tissues, which results in disease.

The UMHS research challenges this long-held theory. The study shows, for the first time, how this subset of HLA genes causes arthritis by activating inflammation-causing cells, as well as bone-destroying cells (known as osteoclasts). This leads to severe arthritis and bone erosion.

We showed how the shared epitope is directly triggering osteoclasts, the very cells that are responsible for joint destruction in people with the disease, says Holoshitz.

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Researchers Uncover Gene's Role in Rheumatoid Arthritis, Findings Pave Way for New Treatments

St. Jude Childrens Research Hospital Washington University Pediatric Cancer Genome Project takes new approach to measuring the repetitive DNA at the end of chromosomes and opens new window on mechanisms fueling cancer

Newswise (MEMPHIS, Tenn. January 24, 2013) Genome sequencing data once regarded as junk is now being used to gain important clues to help understand disease. The latest example comes from the St. Jude Childrens Research Hospital Washington University Pediatric Cancer Genome Project, where scientists have developed an approach to mine the repetitive segments of DNA at the ends of chromosomes for insights into cancer.

These segments, known as telomeres, had previously been ignored in next-generation sequencing efforts. That is because their repetitive nature meant that the resulting information had defied analysis and the data were labeled as junk. But researchers have now traced changes in the volume of telomeric DNA to particular types of cancer and their underlying genetic mistakes. Investigators found that 32 percent of pediatric solid tumors carried extra DNA for telomeres, compared to just 4 percent of brain tumors and none of the leukemia samples studied. The findings were published recently in the journal Genome Biology.

Using this new approach, the investigators have linked changes in telomeric DNA to mutations in the ATRX gene and to longer telomeres in patients with a subtype of neuroblastoma, a cancer of the sympathetic nervous system. Telomere length limits how many times cells can divide. Mechanisms that maintain or lengthen telomeres contribute to the unchecked cell division that is a hallmark of cancer.

This paper shows how measuring the DNA content of telomeres can enhance the value of whole- genome sequencing, said Matthew Parker, Ph.D., the papers first author and a St. Jude postdoctoral fellow. In the case of the ATRX mutation, the telomere findings gave us information about the mutations impact that would have been hard to get through other means.

The results stem from the largest study yet of whole-genome sequencing to measure the content of telomeric DNA. The effort involved whole-genome sequencing of normal and tumor DNA from 235 pediatric patients battling 13 different cancers. For comparison, normal DNA from 13 adult cancer patients was included in the research.

Theres been a lot of interest among cancer researchers into telomere length, said Richard Wilson, Ph.D., director of The Genome Institute at Washington University School of Medicine in St. Louis. While more research remains, we think its important to begin to characterize the genetic sequences that make up the telomeres. Thats a crucial first step to understanding more precisely any role they may play in cancer.

The Pediatric Cancer Genome Project sequenced the complete normal and cancer genomes of more than 600 children and adolescents with some of the most aggressive and least understood cancers. Investigators believe the projects findings will lay the foundation for a new generation of clinical tools. Despite advances, cancer remains the leading cause of death by disease of U.S. children age 1 and older.

The human genome is stored in the four-letter chemical alphabet of DNA, a molecule that stretches more than 3 billion characters in length and provides the instructions for building and sustaining life. Those instructions are the genes that are organized into the 46 chromosomes found in almost every cell.

Each chromosome ends with the same six-letter DNA sequence that is associated exclusively with telomeres. The DNA sequence does not vary, but the number of times it is repeated does, affecting the length of the telomeres. Telomeres shorten each time cells divide, which explains why their length declines naturally with age.

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Gene Sequencing Project Mines Data Once Considered 'Junk' for Clues About Cancer

Public release date: 25-Jan-2013 [ | E-mail | Share ]

Contact: Sibylle Kohlstdt s.kohlstaedt@dkfz.de Helmholtz Association of German Research Centres

About ten percent of all cases of malignant melanoma are familial cases. The genome of affected families tells scientists a lot about how the disease develops. Prof. Dr. Rajiv Kumar of the German Cancer Research Center (Deutsches Krebsforschungszentrum, DKFZ) together with Prof. Dr. Dirk Schadendorf from Essen University Hospital studied a family where 14 family members were affected by malignant melanoma.

The scientists analyzed the genomes of family members and found an identical mutation in the gene for telomerase, an enzyme often called 'immortality enzyme', in all persons studied. Telomerase protects the ends of chromosomes from being lost in the process of cell division and, thus, prevents that the cell ages and dies. The inherited gene mutation leads to the formation of a binding site for protein factors in the controlling region of the telomerase gene, causing it to become overactive. As a result, mutated cells overproduce telomerase and hence become virtually immortal.

This spectacular finding of the family analysis prompted the scientists to also look for mutated telomerase genes in non-inherited (sporadic) melanoma, which is much more common than the familial variant. In most of the tissue samples of melanomas of all stages they found alterations in the telomerase gene switch, which the researchers clearly identified as typical consequences of sun exposure. Even though these mutations were not identical to those found in the melanoma family, they had the same effect: overactive telomerase.

"We don't believe that the telomerase gene in melanoma is mutated by pure chance, but that it is a so-called driver mutation that drives carcinogenesis," says Rajiv Kumar. This is also confirmed by the surprising incidence of this alteration: The telomerase gene is the most frequently mutated gene in melanoma. "This is something we hadn't expected, because malignant melanoma has been genetically analyzed thoroughly. But this mutation always seems to have been overlooked," says Kumar.

Rajiv Kumar, Dirk Schadendorf and their teams are hoping that the alterations in the telomerase gene may be a starting point for developing novel treatment methods for malignant melanoma. A very recent development targeting a specific alteration in the B-RAF gene, which characterizes about half of all melanomas, has shown that this is possible. The mutation gave rise to the development of a targeted drug that can arrest cancer growth. "Substances inhibiting telomerase have already been developed and some of them have even been tested in phase III clinical trials," said Rajiv Kumar. Inhibition of the immortality enzyme might also be able to arrest growth in melanoma.

###

Susanne Horn, Adina Figl, P. Sivaramakrishna Rachakonda, Christine Fischer, Antje Sucker, Andreas Gast, Stephanie Kadel, Iris Moll, Eduardo Nagore, Kari Hemminki, Dirk Schadendorf and Rajiv Kumar: TERT Promoter Mutations in Familial and Sporadic Melanoma. Science 2013, DOI: 10.1126/science.1230062

The German Cancer Research Center (Deutsches Krebsforschungszentrum, DKFZ) with its more than 2,500 employees is the largest biomedical research institute in Germany. At DKFZ, more than 1,000 scientists investigate how cancer develops, identify cancer risk factors and endeavor to find new strategies to prevent people from getting cancer. They develop novel approaches to make tumor diagnosis more precise and treatment of cancer patients more successful. The staff of the Cancer Information Service (KID) offers information about the widespread disease of cancer for patients, their families, and the general public. Jointly with Heidelberg University Hospital, DKFZ has established the National Center for Tumor Diseases (NCT) Heidelberg, where promising approaches from cancer research are translated into the clinic. In the German Consortium for Translational Cancer Research (DKTK), one of six German Centers for Health Research, DKFZ maintains translational centers at seven university partnering sites. Combining excellent university hospitals with high-profile research at a Helmholtz Center is an important contribution to improving the chances of cancer patients. DKFZ is a member of the Helmholtz Association of National Research Centers, with ninety percent of its funding coming from the German Federal Ministry of Education and Research and the remaining ten percent from the State of Baden-Wrttemberg.

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Gene mutation immortalizes malignant melanoma

BioTalk Episode 2: Three Parent Embryos and the Brave New United States
In October of last year, scientists in Oregon made embryos with genes from one man and two women: lacrossetribune.com Rebecca and I discuss this kind of genetic engineering and the "Brave New" United States where there are no restrictions on this or other once unthinkable kinds of human experimentation currently in practice. We also discuss the impact this kind of experimentation has on women. Please leave us feedback at http://www.BioTalkBlog.com Chelsea #39;s website http://www.ReflectionsofaParalytic.com Rebecca #39;s website http://www.MaryMeetsDolly.com

By: Chelsea Zimmerman

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BioTalk Episode 2: Three Parent Embryos and the Brave New United States - Video

By Arthur Caplan, Special to CNN

updated 12:54 PM EST, Thu January 24, 2013

A display of a reconstruction of a Neanderthal man and boy at the Museum for Prehistory in Eyzies-de-Tayac, France.

STORY HIGHLIGHTS

Editor's note: Arthur Caplan is the Drs. William F and Virginia Connolly Mitty professor and director of the Division of Bioethics at New York University Langone Medical Center.

(CNN) -- So now we know -- there won't be a Neanderthal moving into your neighborhood.

Despite a lot of frenzied attention to the intentionally provocative suggestion by a renowned Harvard scientist that new genetic technology makes it possible to splice together a complete set of Neanderthal genes, find an adventurous surrogate mother and use cloning to gin up a Neanderthal baby -- it ain't gonna happen anytime soon.

Nor should it. But there are plenty of other things in the works involving genetic engineering that do merit serious ethical discussion at the national and international levels.

Arthur Caplan

Some thought that the Harvard scientist, George Church, was getting ready to put out an ad seeking volunteer surrogate moms to bear a 35,000-year-old, long-extinct Neanderthal baby. Church had to walk his comments back and note that he was just speculating, not incubating.

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Opinion: Don't clone a Neanderthal baby

By Arthur Caplan, Special to CNN

updated 12:54 PM EST, Thu January 24, 2013

A display of a reconstruction of a Neanderthal man and boy at the Museum for Prehistory in Eyzies-de-Tayac, France.

STORY HIGHLIGHTS

Editor's note: Arthur Caplan is the Drs. William F and Virginia Connolly Mitty professor and director of the Division of Bioethics at New York University Langone Medical Center.

(CNN) -- So now we know -- there won't be a Neanderthal moving into your neighborhood.

Despite a lot of frenzied attention to the intentionally provocative suggestion by a renowned Harvard scientist that new genetic technology makes it possible to splice together a complete set of Neanderthal genes, find an adventurous surrogate mother and use cloning to gin up a Neanderthal baby -- it ain't gonna happen anytime soon.

Nor should it. But there are plenty of other things in the works involving genetic engineering that do merit serious ethical discussion at the national and international levels.

Arthur Caplan

Some thought that the Harvard scientist, George Church, was getting ready to put out an ad seeking volunteer surrogate moms to bear a 35,000-year-old, long-extinct Neanderthal baby. Church had to walk his comments back and note that he was just speculating, not incubating.

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Don't clone a Neanderthal baby

Sixty years after scientists described the chemical code of life an interweaving double helix called DNA researchers have found four-stranded DNA is also lurking in human cells.

The odd structures are called G-quadruplexes because they form in regions of deoxyribonucleic acid (DNA) that are full of guanine, one of the DNA molecule's four building blocks, with the others being adenine, cytosine, thymine. The structure comprises four guanines held together by a type of hydrogen bonding to form a sort of squarelike shape. (The DNA molecule is itself a double strand held together by these building blocks and wrapped together like a helix.)

The new visualization of the G-quadruplex is detailed this week in the journal Nature Chemistry.

"I think this paper is important in showing directly the existence of this structure in vivo in the human genome, but it is not completely unexpected," said Hans-Joachim Lipps, of the University of Witten in Germany, who was not involved in the study. [See Images of the 4-Stranded DNA]

Scientists had shown in the past that such quadruplex DNA could form in test tubes and had even been found in the cells of ciliated protozoa, or single-celled organisms with hairlike appendages. Also there were hints of its existence in human cells, though no direct proof, Lipps said.

But scientists still didn't have concrete evidence for its existence in the human genome. In the new study, researchers, including chemist Shankar Balasubramanian, of the University of Cambridge and Cambridge Research Institute, crafted antibody proteins specifically for this type of DNA. The proteins were marked with a fluorescent chemical, so when they hooked up to areas in the human genome packed with G-quadruplexes, they lit up.

Next, they incubated the antibodies with human cells in the lab, finding these structures tended to occur in genes of cells that were rapidly dividing, a telltale feature of cancer cells. They also found a spike in quadruplexes during the s-phase of the cell cycle, or the phase when DNA replicates just before the cell divides.

As such, the researchers think the four-stranded DNA could be a target for personalized medicine in the future. If they could block these odd ducks perhaps they could stop the rapid cell division of cancer cells.

"We are seeing links between trapping the quadruplexes with molecules and the ability to stop cells dividing, which is hugely exciting," Balasubramanian said in a statement.

The finding "is certainly a technical (not scientific) breakthrough in designing antibodies sensitive enough to demonstrate this structure in vivo in the human genome," Lipps wrote.

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New Genetic Twist: 4-Stranded DNA Lurks in Human Cells

Public release date: 24-Jan-2013 [ | E-mail | Share ]

Contact: Bill Hathaway 203-432-1322 Yale University

Nearly the entire genetic landscape of the most common form of brain tumor can be explained by abnormalities in just five genes, an international team of researchers led by Yale School of Medicine scientists report online in the Jan. 24 edition of the journal Science. Knowledge of the genomic profile of the tumors and their location in the brain make it possible for the first time to develop personalized medical therapies for meningiomas, which currently are only managed surgically.

Meningioma tumors affect about 170,000 patients in the United States. They are usually benign but can turn malignant in about 10 percent of cases. Even non-cancerous tumors can require surgery if they affect the surrounding brain tissue and disrupt neurological functions.

Approximately half of the tumors have already been linked to a mutation or deletion of a gene called neurofibromin 2, or NF2. The origins of the rest of the meningiomas had remained a mystery.

The Yale team conducted genomic analyses of 300 meningiomas and found four new genetic suspects, each of which yields clues to the origins and treatment of the condition. Tumors mutated with each of these genes tend to be located in different areas of the brain, which can indicate how likely they are to become malignant.

"Combining knowledge of these mutations with the location of tumor growth has direct clinical relevance and opens the door for personalized therapies," said Murat Gunel, the Nixdorff-German Professor of Neurosurgery, professor of genetics and of neurobiology, and senior author of the study. Gunel is also a member of Yale Cancer Center's Genetics and Genomics Research Program.

For instance, two of the mutations identified SMO and AKT1 have been linked to various cancers. SMO mutations had previously been found in basal cell carcinoma and are the target of an already approved drug for that form of skin cancer. Another, KLF4, activates a suite of genes and is known for its role in inducing stem cell formation, even in cells that have fully differentiated into a specific tissue type. Mutations in a TRAF7, a gene not previously associated with cancer, were found in approximately one-fourth of tumors. Meningiomas with these mutations are found in the skull base and are unlikely to become cancerous. In contrast, NF2 mutant tumors that flank the brain's hemispheres are more likely to progress to malignancy, especially in males.

Doctors may be able to use targeted chemotherapy on patients with non-NF2 mutations, especially those with recurrent or invasive meningiomas and those who are surgically at high risk. Individualized chemotherapies could also spare patients irradiation treatment, a risk factor for progression of these generally benign tumors. Gunel said it may also be possible to extend these approaches to more malignant tumors.

###

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Genetic landscape of common brain tumors holds key to personalized treatment

Marfan Syndrome
Genetic Disorder Project assigned by Mr. Leal. Citations: medicalnewstoday.com, marfan.com, nhlbi.nih.gov, mayoclinic.com/marfan-syndrome/, genetics.emedtv.com/marfan-syndrome

By: Anna Green

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Marfan Syndrome - Video

Nancy Drew: Shadow at the Water #39;s Edge- Part 5, I fail at finding my room and Origami
Yeaaah, so I keep on forgetting that there are certain times that I can and can NOT upload my videos. So I think that #39;s one of the many ways that gets me discouraged...don #39;t be like me and start something and just fail to finish it. This is not only a habit but literally a family trait...LITERALLY!!! (GENETICS!) XD Honestly, I have NO idea as to why the music is dominating everything. I can #39;t tell you how many times I have adjusted this...it just won #39;t listen! Since my fail to complete the first game, I #39;m going to go ahead and see if I can possibly- seriously- REALLY- complete this one. (Seeing as how I have done it already) One my biggest challenges of complete the last one (Phantom of Venice) were those dog #39;on lock picking puzzles and the very last ones. (Even though I have "cheat notes") A big thing that will be getting me by today will be Arglefumph #39;s videos and research from the internet. Anyone who is watching, if you are anything like me in this, do not be ashamed, for it is a weird/sad thing, but yet probably a normal thing. 🙂 Thank you for watching This game has been created by HER INTERACTIVE, clearly not me. This has been purchased through STEAM. (I believe.) As the others have been purchased through Amazon and BigFish games. THANK YOU!!! Phantom of Venice-(Most likely to be continued...) Shadow at the Water #39;s Edge... (MYSTERIOUS GAME CHOSEN BY THE UPLOADER. Should be coming soon as well...) TAGS: nancy drew her interactive dare to play ryokan hiei japan lol ...

By: IceInMySnowCone

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Nancy Drew: Shadow at the Water's Edge- Part 5, I fail at finding my room and Origami - Video

New Vision: Kontstantin Severinov at TEDxSkolkovo
Konstantin Severinov Professor of Biology at the Waksman Institute, Department of Molecular Biology and Biochemistry at Rutgers University, USA. He is also the Head of Laboratory of genetic regulation of prokaryotic mobile genetic elements at the Institute of Molecular Genetics of the Russian Academy of Sciences. He has also produced over 169 peer-reviewed publications and holds 6 patents in the US In thespirit of ideas worth spreading, TEDx is a program of local, self-organized events that bring people together to share a TED-like experience. At a TEDx event, TEDTalks video and live speakers combine to spark deep discussion and connection in a small group. These local, self-organized events are branded TEDx, where x = independently organized TED event. The TED Conference provides general guidance for the TEDx program, but individual TEDx events are self-organized.* (*Subject to certain rules and regulations)

By: TEDxTalks

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New Vision: Kontstantin Severinov at TEDxSkolkovo - Video

Kinnordy Domina
Sire: Danzante (imp) (De Niro / Weltmeyer) Dam: Gymnastic Star (imp) / Graf Landau (imp) A mature looking 3 year old filly with an absolutely faultless temperament. Domina has recently been started under saddle and has wisdom beyond her years. She is aso a breeding gold mine, a combination of highly sought-after dressage genetics, making her an excellent future breeding prospect. Currently in training with Brent Eastwell. More information at http://www.willowdowns.com.au

By: Brent Eastwell

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Kinnordy Domina - Video

Treating Cancer - Cancer Treatment
Treating Cancer. http://www.CancerUncensored.com. Welcome to today #39;s issue of cancer uncensored. Hi, I #39;m Chris, and I am the author of cancer uncensored, a step-by-step guide to cancer prevention, early detection and cancer survival. In today #39;s video,I would like to present you with an overview of cancer. I #39;m going to briefly talk about what cancer is, what triggers it, what symptoms there are, how you can avoid it. We #39;ll also go over current treatment methods and alternative treatment. I #39;ll also show you where you can go to get the most up-to-date news and breakthroughs. Before we get stuck in, I would like to address two points Firstly, most people are terrified of cancer. I can understand that, as my wife has cancer, but as a society, we mustn #39;t let the dread of the disease prevent us from taking steps to understand it, because that way we can actively prevent it. One in three of us will be diagnosed with cancer within our lifetimes, yet 85% of cancer is avoidable! This video, and my book, cancer uncensored, can tell you how. So absorb as much of this data as you can, because it could save your life. Secondly, you must understand that cancer isn #39;t fully understood. We have a number of very solid theories, and plenty of study data, but if cancer was fully understood, we #39;d be closer to a cure. To quote Thomas Edison, "The doctor of the future will no longer treat the human frame with drugs, but rather will cure and prevent disease with nutrition." But as things stand at the ...

By: CancerUncensored

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Treating Cancer - Cancer Treatment - Video