Archive for the ‘Gene Therapy Research’ Category

Edward Lanphier of Sangamo on engineering genetic cures - at Stem Cells USA RM Congress 2012
Edward Lanphier, CEO of Sangamo, spoke at the Stem Cells USA Regenerative Medicine Congress 2012 on the topic, #39;Engineering genetic cures: employing zinc finger nucleases (ZFNs) in stem cells. #39; The Stem Cells Regenerative Medicine Congress is where pharma, biotech, academia, government and investors come to uncover the technologies, strategies and business models that will help get stem cell and regenerative medicine treatments to market faster and more cost effectively. For more information, go to http://www.terrapinn.com/stemcellsusa. Or, check out our blog at blogs.terrapinn.com/total-biopharma for up to date information on the stem cells, RM and cord blood banking and therapeutics sectors.From:biopharmachannelViews:74 0ratingsTime:24:15More inScience Technology

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Edward Lanphier of Sangamo on engineering genetic cures - at Stem Cells USA

NEW YORK, Dec. 26, 2012 /PRNewswire/ --Scientists from Beth Israel Medical Center and the Icahn School of Medicine at Mount Sinai have announced the discovery of a novel gene for primary torsion dystonia, a debilitating neurological disorder estimated to affect no fewer than 300,000 people in the US and Canada.

Published online December 9 in Nature Genetics, the findings describe the GNAL gene, the first primary torsion dystonia gene that directly points to pathways in the brain's dopamine system as the origin of pathophysiology. Genetic study in two extensively studied dystonia families revealed mutations in GNAL. Further screening of 39 additional affected families identified another six mutations in this gene. The research unveils a new potential therapeutic target and thus an opportunity for developing new treatments. This discovery will also help development of genetic tests to confirm diagnosis, identify unaffected adult carriers, and provide greater reproductive health options for affected families.

The discovery was made through the collaboration of a clinical research team of movement disorder specialists in the United States and Canada led by Susan Bressman, MD, Chair of the Mirken Department of Neurology at Beth Israel Medical Center and the work of the molecular genetic laboratory at the Icahn School of Medicine at Mount Sinai, led by Laurie Ozelius, PhD, Associate Professor in the Department of Genetics and Genomic Sciences there. "Ultimately, this work derived from the generosity of patients and families who participated in these studies for a 25 year period," says Dr. Bressman. "The study emphasizes the great utility of a truly long-term, collaborative study of patients and families and the importance of investing in the clinical and laboratory infrastructure to keep the study of these patients and families an ongoing venture."

Primary torsion dystonia is a movement disorder characterized by repetitive twisting muscle contractions and postures that can affect the face, neck, arms, legs, or torso. Common symptoms include tremors, voice problems, or a dragging foot. Adults and children of all backgrounds may be affected. The disorder is dominantly inherited with reduced penetrance, making it difficult to predict which family members may be at risk without genetic screening. Three additional genes associated with primary torsion dystonia have been identified.

"The technique used for the identification of the GNAL genecalled exome sequencingis a powerful and efficient tool that will accelerate the pace of dystonia gene discovery and, consequently, our understanding of the pathways involved in primary torsion dystonia," says Dr. Ozelius, who led the laboratory effort.

"Any new gene offers the potential to develop new therapeutics, but because GNAL belongs to a well studied pathway, other components in this pathway may also be targets for drug development" adds Tania Fuchs, PhD, Instructor in the Department of Genetics and Genomic Sciences of the Icahn School of Medicine at Mount Sinai, who is first author of the paper.

This research was funded in part by the Dystonia Medical Research Foundation, the Bachmann-Strauss Dystonia & Parkinson's Foundation, and the National Institute of Health (NIH).

Study authors also include scientists from Scripps Research Institute; Toronto Western Hospital, University of California, San Francisco; Emory University School of Medicine;, Jefferson Hospital for Neuroscience, Massachusetts General Hospital and Institute National de la Sante et la Recherche Medicale (INSERM).

The abstract may be found at: http://www.nature.com/ng/journal/vaop/ncurrent/full/ng.2496.html

About the Dystonia Medical Research Foundation:Founded in 1976, the Dystonia Medical Research Foundation (DMRF) is a 501(c)3 non-profit organization dedicated to serving people with dystonia and their families. The DMRF has grown from a small family-based foundation into a dynamic membership-driven organization led by a Board of Directors and network of volunteers with personal connections to dystonia. For over 36 years, the DMRF has supported and stimulated the field of dystonia research. Work supported by the DMRF has led to an overall better understanding of dystonia as well as breakthroughs in genetics and therapeutics. In addition to funding investigators, the scientific program of the DMRF includes contracts with pharma/biotech companies on targeted projects, scientific meetings and workshops, a clinical fellowship program, brain bank collective, international medical symposiums, and serving as an administrative center for the Dystonia Coalition. The Medical and Scientific Advisory Council (MSAC) is comprised of pre-eminent researchers and clinicians from various scientific disciplines. The members are responsible not only for grant review but also for setting the direction of the research to find more effective treatments and ultimately a cure.

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Researchers at Beth Israel Medical Center and the Icahn School of Medicine at Mount Sinai Discover New Genetic Basis ...

Does Humanity Have a Future? (Interlude)
What was different in the 20th century? Certainly, the technologies underlying the weapons of mass destruction (WMD) - nuclear, biological, and chemical (NBC) - were powerful, and the weapons an enormous threat. But building nuclear weapons required, at least for a time, access to both rare - indeed, effectively unavailable - raw materials and highly protected information; biological and chemical weapons programs also tended to require large-scale activities. The 21st-century technologies - genetics, nanotechnology, and robotics (GNR) - are so powerful that they can spawn whole new classes of accidents and abuses. Most dangerously, for the first time, these accidents and abuses are widely within the reach of individuals or small groups. They will not require large facilities or rare raw materials. Knowledge alone will enable the use of them. Thus we have the possibility not just of weapons of mass destruction but of knowledge-enabled mass destruction (KMD), this destructiveness hugely amplified by the power of self-replication. I think it is no exaggeration to say we are on the cusp of the further perfection of extreme evil, an evil whose possibility spreads well beyond that which weapons of mass destruction bequeathed to the nation-states, on to a surprising and terrible empowerment of extreme individuals. Bill Joy, Why the Future Doesn #39;t Need UsFrom:DerivedEnergyViews:0 5ratingsTime:02:44More inEducation

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Does Humanity Have a Future? (Interlude) - Video

The O #39;Brien sisters: Battling cancer together
Meet Kathleen, Angel and Brenda O #39;Brien. From the outside looking in, they look like three sisters who are fiercely close. Take a closer look, and you learn what bonds them together is much more than childhood memories and genetics. The O #39;Brien sisters have all heard the painful news: Yes, you have breast cancer. They all have undergone painful surgeries and they all know every last treatment option. For more informaton please visit http://www.hlntv.comFrom:HLNViews:8 1ratingsTime:04:51More inNews Politics

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The O'Brien sisters: Battling cancer together - Video

What Is Genetics?
Gene ScienceScience expert Emerald Robinson explains what genetics is and how scientists study genes, heridity, and variation in living organisms.To view over 15000 other how-to, DIY, and advice videos on any topic, visit http://www.monkeysee.comFrom:monkeyseevideosViews:1 0ratingsTime:02:07More inHowto Style

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What Is Genetics? - Video

Non-surgical treatments for wrinkles and dark circles; puffy eyes require surgery
This woman is looking for non-surgical options to treat dark circles and wrinkles under her eyes. Dr. Prasad uses non-surgical treatments for wrinkles with fractional CO2 lasers, and dark circles can be helped with platelet-rich plasma treatment. Platelet-rich plasma involves drawing blood from the patient, and spinning it to concentrate the platelets, which are the healing factors of the blood. Once injected into the skin, platelet-rich plasma stimulates collagen and new blood supply. Wrinkles and dark circles under the eyes are caused by a number of factors, including genetics, ethnicity, and being around smoke. From the photo the woman submitted, Dr. Prasad noticed that there is puffiness in the under eye area. To treat puffy eyes, which is called lower eyelid fat prolapse, there are no options aside from surgery. In Dr. Prasad #39;s over 20 years of experience as an oculofacial cosmetic surgeon, he has seen people treat different areas in isolation to avoid surgery, but in the end they aren #39;t happy with the results. Lower eyelid fat prolapse is caused by fat behind the lower eyelids being pushed forward and creating a puffy appearance. In this case, Dr. Prasad recommends traditional lower eyelid blepharoplasty or transconjunctival blepharoplasty to reduce and sculpt the fat pockets for a more natural contour. As a leading specialist in cosmetic surgery in the eyes and face, Dr. Prasad does these procedures with such finesse that eye doctors can #39;t tell they were ever done ...From:Amiya Prasad, M.D.Views:0 0ratingsTime:06:46More inScience Technology

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Non-surgical treatments for wrinkles and dark circles; puffy eyes require surgery - Video

Genetic Engineering, Stem Cell Research, and Human Cloning
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Genetic Engineering, Stem Cell Research, and Human Cloning - Video

Cybertronica Obscura Episode 6
Weekly show; movies about #39;the future, #39; cyborgs, computers, artificial intelligence, robots, androids, clones, genetic engineering, cybernetics, dystopias, cyberpunks, virtual reality, and related subjects.From:SternwiseViews:14 0ratingsTime:52:48More inEducation

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Zeus, wrapped around my leg.
My pet Boa, Zeus, who at last shed, is 59 3/4 " long. Not even 2 years old yet. A bit small for about a 2 year old, but he just like to "camp",as I call it, wrapped around my leg or on the arm of my chair. He will stay there for hours,if you let him. I didn #39;t think, snakes liked to,"cuddle".LOL. I have 2 ball pythons. One is 5 years old.(abut 55" long), and the "baby ball", who is 2 years old, is about 36" long. And have 3 Corn snakes, each about 30" long. But Zues, is the "big baby",of them all. Had him sense he was a week old. And raised him on my "lap", so to speak. A good snake,*imo. But not for a beginner snake lover. This guy will grow to over 6 feet, easy. If not more. Depending on genetics. Will post more videos, as time goes by. "Merry Christmas"From:chemox706Views:0 0ratingsTime:01:41More inEntertainment

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Zeus, wrapped around my leg. - Video

Get muscles workout exercise - Moscow fitness clubs. Moskva gym. Downtown
Moscow fitness clubs. Moskva gym. Downtown ______________________________________________________________ Yurii Spasokukotskyi, a personal trainer and bodybuilding champion came into the sport in 1994. Initialy he used to have narrow shoulders, weak muscles and a big fat belly. But even after 7 years of regular gym training 3-4 times a week didn #39;t bring hime good results. The reason was that regular and hard workout vs bad genetics was not cool enough without a competent training system. Then Yurii has developed his own system which works 100% and may ba suitable for everybody. And he himself got much greater results in bodybuilding during that one year than during those 7 years of training before. Now all people, who want to get a significant progress in bodybuilding and fitness are getting success with Yurii. He gives personal trainings in Skype and has thousands of happy clients around the world. Build muscle really fast: biceps.com.ua In today #39;s episode, it #39;s time to build some MONSTER BICEPS! I #39;ve gotten a lot of questions lately in the comments about what I do for my arms, and how to develop a big biceps . In this video I #39;m going to show you two of the exact exercises I use to get big arms myself. Building a biceps "peak" will make a HUGE difference in how big your biceps appear. If they #39;re shaped right, your biceps will appear much bigger than someone whose are the same size, but whose biceps do not have a dramatic peak. Developing your bracs (muscles outside your ...From:YuryfromUkrainViews:3 0ratingsTime:03:47More inShows

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Rushed or Sloppy Training, Lesson Two
Video lesson from WalkenStrutt Protection Dogs. Lesson focuses on the necessity of training dogs for a "failed" scenario and choosing good genetics.From:FocusDog7911Views:0 0ratingsTime:02:54More inPets Animals

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How Oncolytic Viruses Kill Cancer Cells: research, trials, cancer treatment, cure for cancer?
More: http://www.virttu.com . How oncolytic viruses work to kill cancer cells in melanoma, head and neck, prostate cancer and glioblastoma brain timours. Replication of oncolytic viruses inside tumours. Pre-clinical trials. Phase I, Phase II and Phase III clinical trials on oncolytics. Use of oncolytic viruses to treat advanced malignant melanoma and mestatases -- Amgen research using an oncolytic virus developed from HSV (Herpes Simplex Virus). Problems with traditional chemotherapy -- side effects. Why Amgen bought an oncolytic viruse for $500m in cash and $500m to be paid if oncolytic trials are fully successful. Investor interest in oncolytic viruses. Lessons from the history of research and development in monoclonal antibodies in cancer treatment. Why targeted cancer therapy -- a so-called "magic bullet" is so needed. How oncolytic viruses have been modified so that they cannot replicate in normal cells, but are still able to divide in a wide variety of human cancer cells. History of oncolytic viruses. Arming oncolytic viruses. Using viruses like Seprehvir (HSV-1716), adapted to carry an additional payload extra genes which teach infected cancer cells to take up a compound containing radioactive iodine from the blood, delivering a micro-dose of radiation inside individual cancer calls. Or adding a gene which teaches cancer cells how to split a harmless pro-drug into two, inside the cell, releasing a very toxic chemo (alkylating agent). Targetting oncolytic viruses -- by ...From:pjvdixonViews:46 3ratingsTime:22:35More inEducation

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How Oncolytic Viruses Kill Cancer Cells: research, trials, cancer treatment, cure for cancer? - Video

Dan Civa interview, Species Gallery - June 1997 for VLTV
Human Animal in paintings and drawings with the combination of human being and animal, referring to coming possibilities in the future of genetic engineering. Ideas and inspiration comes from personal interest in experiments and new ways of thinking by results in science and research, today and tomorrow. Oil paintings and drawings, in realistic style, are reflecting portrait examples of xenotransgenetic manipulation with human beings and animals. Probably a hypothetical, imaginary development of today, but a foreseeable realistic possibility of tomorrowFrom:Dan CivaViews:2 0ratingsTime:06:56More inScience Technology

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Geoengineering Through Aerial Dispersion in Brevard County, Florida / Aerial Acoustic Acclimation
Unknown dispersion over Brevard County, Florida on February 23, 2009. It has been discovered that multiple variations of biological, chemical, synthetic acoustical engineering types of dispersions have been documented in the atmosphere over Florida by scientists. It is not known exactly what these parasitic Rockefeller cartel scientists are trying to accomplish. Geo-engineering, weather modification, acoustic acclimation, population control, genetic engineering terraforming of the planet have all been documented potentials probabilities.From:Geoengineering101Views:0 0ratingsTime:01:58More inScience Technology

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Geoengineering Through Aerial Dispersion in Brevard County, Florida / Aerial Acoustic Acclimation - Video

Plug Lay: Krisz Deak live @ RTS.FM 31.03.2012 - visual art by Thief
Krisz Deak live act at RTS.FM Budapest recorded and streamed live 31.03.2012 at http://www.rts.fm under our Plug Lay showcase . Visuals are provided by Thief. Enjoy! The full audiovisual set can watched online and download in mp3 format also available for registered users from: http://www.rts.fm Plug Lay showcase on RTS.FM http://www.rts.fm http://www.facebook.com Krisztian Deak (1979) Music has been an essential part of his life since his childhood. It probably has something to do with genetics since his father was also a musician and Krisztian grew up with synthesizers, organs and other instruments around him. At the age of 17, he started to work with music on a more serious level. At first, he performed in his hometown in local pubs and Sky Music Radio, which is a local cable radio, also played his music. He moved to Budapest in 2001 where he started a job in a store selling musical instruments. At this very store, he met his future partner and friend, Kalman Nemeth (aka Father Omichron) who was playing in Radio Tilos back then. In 2004, he got his degree in sound engineering, which helped him improving his skills. From that point, making music became the most important thing in his life. Around 2005, they created the formation called Hardtek Production with Father Omichron. They made experimental dance music with a classic techno sound. After a few years of experimenting, they made deeper and clearer sounds. In 2011, Zoltan Solomon joined this formation as well now performing under the name ...From:RTSfmbudapestViews:59 3ratingsTime:01:00:48More inMusic

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Plug

Grow update,tga genetics g13 labs
Third dimension and blue OGFrom:bababludrawzViews:5 6ratingsTime:04:08More inPeople Blogs

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Grow update,tga genetics

Own the Street
Herd Sires: http://www.alianzaherdsires.com Alpaca Genetics: http://www.aplpacagenetics.comFrom:SixthDayFarmViews:0 0ratingsTime:02:48More inPets Animals

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The Revolution of the Pig - Production Trailer
Smiling Pig Productions presents its yearly production trailer for 2013 - "The Revolution of the Pig"! Over the past year, we #39;ve brought up our production quality significantly to match our ambitions and style of cinema. As a look-back on 2012 #39;s amazing projects, the "Revolution" production trailer highlights some of the sweetest shots, most dramatic moments, and most spectacular visual effects. The Official Smiling Pig Productions website is down for renovations until late December, but when it #39;s up again, it #39;ll be your destination for upcoming trailers, blog posts, and neat production materials: smilingpigproductions.com Be sure to like us on Facebook for exclusive trailers, updates, and more: http://www.facebook.com Featuring actors and clips from: English Meal Time - Michael Langford, Si Duo Fan Comm Tech IRL - Varun Mittal Shit Happens Again - Mack Biduk, Conor Rolland, Matthew Acton Ryan vs Wild: Rugged Rockies - Ryan Conrad Solar Puns - Kiran Rao, Ryan Conrad Defection - Michael Langford, Denis Velikzhanin, Matthew Acton, Conor Rolland The Making of Defection - Chris Diec President Madagascar: Shut Down Everything - Michael Langford, Daniel Yang, Mack Biduk, Alexander Wen, Chris Diec, Matthew Findley, Conor Rolland, Kiran Rao Shit Keeps Happening - Conor Rolland, Mack Biduk, Matthew Acton Five - Conor Rolland, Daniel Yang, Danny Luo, Melissa Donaldson Five: Behind the Scenes - Michaela White, Charlie Wang, Nikita Gupta, Kelvin Cheung, Alexander Wen, Andriy Predmyrskyy ...From:smilingpigproductionViews:4 0ratingsTime:02:09More inFilm Animation

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The UTI Show: Unrelated Clips I
A series of unrelated, never before seen clips from the UTI Show days, back when we were still in high school. Today we revisit a very late night at Joe #39;s house with guest star the infamous finger-destroying shock game. I think this must have been around 2009, when rationality was a thing only rumoured of in conspiratorial whispers. Here #39;s a little run down on what we #39;ve all been up to since The UTI Show went on #39;hiatus #39;. Next year I will be doing my third year of uni, in genetics, zoology and a little biochemistry. Haven #39;t been filming because everyone disappeared into the void that is uni/work, instead I #39;ve been working on music which I will now shamelessly advertise. deathinadreamscape.bandcamp.com Joe is working as a baker #39;s assistant, also starting his first year at uni with computer science. His hair is exactly the same, on head and back, and he is as angsty as ever. Daniel is working as a bartender at Twelve Below. He is also as the drummer of the band The Fu King, which I will now shamelessly advertise. http://www.youtube.com Rory is contemplating changing his philosophy/psychology degree at uni because it is the equivalence of polytech, and no one wants to be associated with that FILTHY PLACE. He enjoys gardening and romantic sea food dinners. Nike is working full time at a pharmaceutical company, delivering thousands of dollars worth of goods in little breakable boxes. We #39;re still not sure where he lives. Trollhammaren Lute Cover http://www.youtube.comFrom:FaithlessFate87Views:2 0ratingsTime:04:20More inComedy

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Catherine Malabou. Epigenetics and Plasticity. 2012
#8234;www.egs.edu Catherine Malabou, philosopher and author, talking about the relationship between genetics and the philosophical concept of life. In this lecture Catherine Malabou discusses the mechanization of life, Derrida #39;s concept of the trace as bare life, epigenetics as the transformation of genetic code and the development of the brain in relationship to Michel Foucault, Girogio Agamben, Jacques Derrida, Martin Heidegger, François Jacob, Daniel Dennet and Thomas Jenuwein focusing on determinism, fragility, zoe, bios, dasein, stem cells, the passage from genotype to phenotype, interfering RNA, neural plasticity, symbolic life and biology. Public open lecture for the students and faculty of the European Graduate School EGS Media and Communication Studies department program Saas-Fee Switzerland Europe. 2012. Catherine Malabou. Catherine Malabou, Ph.D., born in 1959, was a student at the École normal supérieure (ENS) and Sorbonne University in France. She wrote her dissertation on Georg Wilhelm Friedrich Hegel under the direction of the French philosopher Jacques Derrida, completing it in 1994. The thesis was published in 1996 under the title L #39;Avenir de Hegel, plasticité, temporalité, dialectique (The Future of Hegel: Plasticity, Temporality, and Dialectic). Catherine Malabou has taught at Nanterre University in Paris, the University of California at Berkeley, the New School for Social Research in New York City and currently is a full-time professor at the Centre for ...From:egsvideoViews:1 0ratingsTime:01:36:54More inEducation

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WAS -IL Association: Prof. Adrian T., From Laboratory to Clinic
#1492; #1506; #1502; #1493; #1514; #1492; #1492; #1497; #1513; #1512; #1488; #1500; #1497; #1514; #1500; #1514; #1497; #1505; #1502; #1493; #1504; #1514; #1493; #1493; #1497; #1505; #1511; #1493; #1496; #1488; #1493; #1500; #1491; #1512; #1497; #1509; #39; - #1506;" #1512; The Israeli Wiskott Aldrich Syndrom Association (RA) office@was.org.il The First Israeli Wiskott Alrich Syndrom meeting - June 1st 2012 Wiskott Aldrich Syndrom: From Laboratory to Clinic Prof. Adrian Thrasher, MB BS PhD MRCPCH FRCP FM edSCi Consultant Immunologist GOSH, Director of Center for Immunodeficiency Director of Gene Therapy Program ICH/GOSHFrom:WASISRAELViews:0 0ratingsTime:28:04More inNonprofits Activism

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WAS -IL Association: Prof. Adrian T., From Laboratory to Clinic - Video

WAS -IL Association: Prof. Adrian T., Case study- treating XLT, options and opinions
#1492; #1506; #1502; #1493; #1514; #1492; #1492; #1497; #1513; #1512; #1488; #1500; #1497; #1514; #1500; #1514; #1505; #1502; #1493; #1504; #1514; #1493; #1493; #1497; #1505; #1511; #1493; #1496; #1488; #1493; #1500; #1491; #1512; #1497; #1509; #39; - #1506;" #1512; The Israeli Wiskott Aldrich Syndrom Association (RA) office@was.org.il The First Israeli Wiskott Alrich Syndrom meeting - June 1st 2012 Wiskott Aldrich Syndrom: The question of treating XLT boys , options and opinions Prof. Adrian Thrasher, MB BS PhD MRCPCH FRCP FM edSCi Consultant Immunologist GOSH, Director of Center for Immunodeficiency Director of Gene Therapy Program ICH/GOSHFrom:WASISRAELViews:2 0ratingsTime:21:43More inNonprofits Activism

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GeneX (2012) full movie RESYNCED .mp4
This short movie has been made by a group of M. Sc Biotechnology students, as part of our "creativity assignment" for the Genetic Engineering subject. The work is purely fiction, and made only for entertainment. Do not try to find any scientific logic in the movie, just sit back, relax, watch, and enjoy!! Thanks!! - M. Sc Biotechnology (2011-13) VIT University, India PS- Feel free to comment your views on our humble effort..From:stillscrewingyouViews:16 0ratingsTime:28:44More inEducation

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[BIOS 332] DNA: How it Can Store Information and How it is Shaped - Jason Tresser
BIOS 332: Genetics How it Can Store Information and How it is Shaped September 7, 2012From:BiolaUniversityViews:3 0ratingsTime:50:18More inEducation

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[BIOS 332] DNA: How it Can Store Information and How it is Shaped - Jason Tresser - Video

[BIOS 332] Origins of Life and Hereditary Genetics - Jason Tresser
BIOS 332: Genetics Origins of Life and Hereditary Genetics September 26, 2012From:BiolaUniversityViews:2 0ratingsTime:49:35More inEducation

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