Archive for the ‘Gene Therapy Research’ Category

Icelandic genetic research company deCODE together with scientists from the Landsptali National University Hospital of Iceland and researchers in Holland, Germany and the United States have discovered a second gene variant to confer a high risk of acquiring the more common, late-onset of Alzheimers disease.

The variant was also found to predict poorer cognitive function in older individuals who do not have Alzheimers disease. The results of the research were published in the New English Journal of Medicine on Wednesday.

According to CEO of deCODE and lead author Kri Stefnsson, the results will provide new focus for drug development. The discovery of variant TREM2 is important because it confers high risk for Alzheimers and because the genes normal biological function has been shown to reduce immune response that may contribute to the disease. These combined factors make TREM2 an attractive target for drug development, he said.

The researchers obtained the genome sequences of 2,261 Icelanders and identified sequence variants that were likely to affect protein function.

ZR

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Icelandic Genetic Research Company Find Alzheimer’s Gene Variant

Genetic Engineering Controversy HD
A presentation on genetic modification for our freshmen seminar at Penn State University. We discuss the issues and facts surrounding the controversy about genetically modified foods, animals, and plants.From:Benjamin FowlerViews:11 0ratingsTime:33:07More inScience Technology

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Genetic Engineering Controversy HD - Video

Transformers: Beast Wars Classic Deluxe Rhinox Action Figure
Special Price Link: http://www.demizzy.com Beast Wars Rhinox Action Figure Bio-genetic engineering has allowed the Transformers to create a perfect cybernetic fusion between ferocious animals and mechanical technology. The result: heroic Maximals vs. evil Predacons! Robot warriors disguised as wild animals in an explosive fight to the finish the Beast Wars have begun! Hasbro produced this line of action figures based on the animated hit. Beast Wars. Heroic Maximal Rhinox transforms from Defense Robot to Rhino and back and features SpinFrom:KieraARogerswViews:0 0ratingsTime:00:50More inPeople Blogs

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Transformers: Beast Wars Classic Deluxe Rhinox Action Figure - Video

Biology: Understanding Genetic Engineering
From Advanced Listening Comprehension Third EditionFrom:GeneJarvisViews:2 0ratingsTime:10:01More inPeople Blogs

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Biology: Understanding Genetic Engineering - Video

GMO babies now being engineered in labs
A genetically modified organism (GMO) is an organism whose genetic material has been altered using genetic engineering techniques. GMO babies now being engineered in labsFrom:extremumspiritumViews:0 0ratingsTime:01:10More inNews Politics

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GMO babies now being engineered in labs - Video

Fields of (un)certainty: some issues of genetic engineering in agriculture
A talk by Benson Issac, faculty, Azim Premji University at Azim Premji University September 26, 2012 About the Topic Debates around scientific, social, economic and environmental risk and uncertainities have been an integral part of the controversy around the introduction of GMOs in agriculture in India. After Bt cotton - the first crop that was cleared for commercial cultivation, all proposed genetically modified food crops have been stopped from receiving clearances at various stages of the regulatory process. The talk will discuss these uncertainties and the various stakeholder positions -- from organic farmers to corporations and the government. The talk will foreground the proposed changes to be introduced by the BRAI bill and the implications it has on the regulatory system, centre-state relations and linked issues of environmental governance and agricultural policy. About the Speaker Benson Issac , has been with the Azim Premji Univeristy for over a year. He is interested in issues of alternative livelihoods that bring together the agency of young people and their world of work, traditional skills, issues of social and economic sustainability. He is involved closely with a group of young organic farmers from around Bangalore Rural District. He is keenly interested in issues of traditional artisans and is exploring ways of working with them, that will look at artisans as not merely producers seeking a market but people with alternative worldviews and knowledge ...From:AzimPremjiUniversityViews:0 0ratingsTime:01:28:25More inScience Technology

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Fields of (un)certainty: some issues of genetic engineering in agriculture - Video

Inside Out By Cory Quirino Philippine Daily Inquirer

(Part I)

Confusion rules the day if you read up on too many approaches to living the wellness lifestyle, especially if the topic is dieting. The result: information overload. There are no fast and easy answers. Regarding your wellness issues, here are answers to some of your questions.

Q: Heart disease runs in the family, and I fear the same fate as my fathers. What should I do?

While genetics plays a major role in your predisposition toward certain illnesses, positive lifestyle changes have the power to alter 50 percent of your outlook. So, fear not. You are not doomed to your genetic fate. Especially if you are taking charge of your health today.

To do:

1. See your cardiologist, nutritionist, fitness trainer.

2. Make immediate changes in your habits, especially if you have many bad ones, like drinking alcohol, smoking, not exercising and others.

We have all heard stories about people in their early 40s who are careful with their diets and exercise regularly yet suffer sudden heart attacks. Doctors have known that a healthy lifestyle can prevent heart disease. However, it has been discovered that a lack of certain nutrients can lead to heart problems.

There is the Nurses Health Study being conducted at Harvard Medical School, and Brigham and Womens Hospital in Boston. After following over 73,000 nurses, it was found that a diet rich in vitamin E reduced heart attack risk by 52 percent; vitamin C reduced risk of 43 percent and betacarotene reduced risk by 38 percent. These nutrients protect your arteries. The other nutrients are CoQ10 and selenium which nutrition-oriented doctors recommend. Garlic has been used for centuries to clean up the blood and the heart. Studies indicate that eating one clove of fresh garlic daily can significantly lower total cholesterol. If you develop indigestion, consider garlic oil capsules taken during meals.

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You are not doomed to your genetic fate

Genetic differences identified in children with sagittal craniosynostosis.

Sacramento, Calif. (PRWEB) November 18, 2012

"We have discovered two genetic factors that are strongly associated with the most common form of premature closure of the skull," said Simeon Boyadjiev, professor of pediatrics and genetics, principal investigator for the study and leader of the International Craniosynostosis Consortium.

"These findings may one day lead to prenatal screening and diagnostic tests for this condition or early interventions to prevent it," said Boyadjiev, who is a researcher affiliated with the UC Davis MIND Institute.

The study, "A genome-wide association study identifies susceptibility loci for non-syndromic sagittal craniosynostosis near BMP2 and within BBS9," is published online today in the journal, Nature Genetics.

During fetal and early child development, the skull is made of separate bony plates that allow for growth of the head. The borders between the plates do not normally fuse completely until a child is about 2 years old, leaving temporary "soft spots" at the intersection of the seams.

If the bones fuse too early the condition called craniosynostosis a child will develop an abnormally shaped head. Left untreated, the disorder causes complications due to brain compression, such as neurologic and visual problems and learning disabilities. Typically, craniosynostosis requires extensive neurosurgical correction.

About 20 percent of cases of craniosynostosis have previously been linked to a number of different genetic syndromes, but the vast majority of cases (not associated with a syndrome involving other birth defects) arise without any known family history or cause. The most common form of non-syndromic craniosynostosis affecting about 1 in 5,000 newborns involves the sagittal suture, the main seam that runs down the center of the top of the skull. These cases were the subject of the investigation.

Although the condition has long been thought to be partially determined by genes it is three times more common in boys than in girls, and identical twins are much more likely to both be affected than non-identical twins the exact basis was unclear.

To help determine the cause, the investigators conducted the first genome-wide association study for the disorder, which involves scanning the entire genome of a group of people with craniosynostosis and comparing it to a control group of people without the condition. The study searched for single nucleotide polymorphisms (abbreviated as SNPs and called "snips") that are associated with craniosynostosis. SNPs are DNA changes in which a single nucleotide differs from the usual one at that position. There are some three billion nucleotides, the basic building blocks of DNA, in the human genome.

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UC Davis Researchers Find Likely Genetic Basis of Premature Skull Closure in Infants

Researchers at Mount Sinai School of Medicine have validated new genetic links for sagittal craniosynostosis, a common birth defect in which the bones that form the sides and top of the skull, fuse prematurely.

New York, NY (PRWEB) November 18, 2012

Craniosynostosis is one of the ten most common birth defects, occurring in about 1 out of every 2,500 live births. The sagittal form of craniosynostosis, which impedes growth of the skull so that the shape becomes elongated, occurs in about half the cases, or 1 in 5,000 live births. Unless it is treated surgically to release pressure on the brain within the first year of life, it interferes with brain growth causing neurologic deficits. Non-syndromic sagittal craniosynostosis is not associated with other abnormalities.

Until now, efforts to improve the health outcomes of infants born with sagittal craniosynostosis have been limited to surgery performed by neurosurgical and plastic surgery teams. But researchers have been focusing on the contribution of genetics, as well as environmental triggers.

To investigate the genetic associations, the International Craniosynostosis Consortium studied 130 trios (the affected child and both parents). Very strong associations for genetic markers near the BMP2 [bone morphogenetic protein] gene on chromosome 7 and also within the BBS9 [Bardet-Biedel syndrome 9] gene on chromosome 20 were found, and we replicated it with 172 cases and 548 controls said Ethylin Wang Jabs, MD, PhD, Professor of Genetics and Genomic Sciences, Developmental and Regenerative Biology, and Pediatrics at Mount Sinai School of Medicine. This association suggests that individuals carrying these genetic markers may have more than a four-fold risk of having sagittal craniosynostosis, added Inga Peter, PhD, Associate Professor of Genetics and Genomic Sciences. To find so much power, this is a big breakthrough.

The findings open the door to more genetic research. Investigators will pursue sequencing studies, perhaps finding other loci and genes of interest, Dr. Jabs added.

Other Mount Sinai coauthors include Monica Erazo, Xiaoqian Ye, Edmond Ainehsazan, Lisong Shi, and Peter J. Taub.

The National Institutes of Health and Centers for Disease Control and Prevention supported this research. Genotyping was performed at the Center for Inherited Disease Research at the National Institutes of Health. Participants were recruited and evaluated through the collaborative effort of the International Craniosynostosis Consortium.

One of the first of its kind in the New York area, Mount Sinais Congenital Anomalies and Craniofacial Program led by Dr. Jabs has been at the forefront of genetics and clinical research in congenital abnormalities, especially those of the head, neck, and limbs. Patients are seen by clinical geneticists that are experts in dysmorphology as well as by the Craniofacial and Cleft Clinic with a multidisciplinary team of geneticists, pediatricians, speech therapists, dentists, otolaryngologists, plastic surgery, maxillofacial surgeons, neurosurgery, and ophthalmologists, co-directed by Drs. Lester Silver and Peter Taub. The research focus of Dr. Jabs' laboratory at Mount Sinai has been to increase our understanding of the molecular basis of human malformation disorders and to develop new preventive and therapeutic interventions.

About The Mount Sinai Medical Center

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Common Cranial Birth Defect: Mount Sinai Researchers Validate Genetic Links

November 19, 2012

redOrbit Staff & Wire Reports Your Universe Online

A new study of stem cells derived from skin tissue has challenged the commonly held notion that a persons cells all share the same DNA sequence, arguing instead that genetic variation may occur to a greater extent than experts had previously believed.

Researchers at the Yale School of Medicine set out to challenge the theory that human cells are comprised of identical genetic material, and that a bodys functions are governed by that blueprint. They set out to test a competing hypothesis that as DNA is copied from mother to daughter cells, deletions, duplications, and alternations to the sequence of the DNA could occur, and could affect entire groups of genes.

According to the university, that notion has been incredibly difficult to test, but Dr. Flora Vaccarino, a professor of child psychology at Yale, and colleagues did so by using whole genome sequencing to analyze induced pluripotent stem cells (iPS) taken from the upper, inner arms of a pair of different families.

They spent 24 months characterizing those iPS cell lines and comparing them to the skin cells from which they originated, and while the genomes of each cell group were similar, Dr. Vaccarinos team was able to pinpoint multiple deletions or duplications that involved thousands of base pairs of DNA, the university explained.

Additional research showed that at least half of the variations they observed pre-existed in a small percentage of skin cells. Those differences were noticeable in the iPS cells because each line of those stem cells originated from either a single or an extremely limited number of skin cells.

We found that humans are made up of a mosaic of cells with different genomes, Dr Vaccarino said in a statement. We saw that 30 percent of skin cells harbor copy number variations (CNV), which are segments of DNA that are deleted or duplicated. Previously it was assumed that these variations only occurred in cases of disease, such as cancer. The mosaic that weve seen in the skin could also be found in the blood, in the brain, and in other parts of the human body.

In the skin, this mosaicism is extensive and at least 30 percent of skin cells harbor different deletion or duplication of DNA, each found in a small percentage of cells, she added. The observation of somatic mosaicism has far-reaching consequences for genetic analyses, which currently use only blood samples. When we look at the blood DNA, its not exactly reflecting the DNA of other tissues such as the brain. There could be mutations that were missing.

Vaccarinos team, which also included fellow researchers Mark Gerstein, Sherman Weissman, Alexander Eckehart Urban, Alexej Abyzov, Jessica Mariani, Dean Palejev, Ying Zhang, Michael Seamus Haney, Livia Tomasini, Anthony Ferrandino, Lior A. Rosenberg Belmaker, Anna Szekely, Michael Wilson, Arif Kocabas, Nathaniel E. Calixto, Elena L. Grigorenko, Anita Huttner, and Katarzyna Chawarska, published their findings in Sundays edition of the journal Nature.

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Study Reveals Genetic Variations Occur At The Cellular Level

Public release date: 18-Nov-2012 [ | E-mail | Share ]

Contact: Karen N. Peart karen.peart@yale.edu 203-432-1326 Yale University

The prevailing wisdom has been that every cell in the body contains identical DNA. However, a new study of stem cells derived from the skin has found that genetic variations are widespread in the body's tissues, a finding with profound implications for genetic screening, according to Yale School of Medicine researchers.

Published in the Nov. 18 issue of Nature, the study paves the way for assessing the extent of gene variation, and for better understanding human development and disease.

"We found that humans are made up of a mosaic of cells with different genomes," said lead author Flora Vaccarino, M.D., the Harris Professor of Child Psychiatry at the Yale Child Study Center. "We saw that 30 percent of skin cells harbor copy number variations (CNV), which are segments of DNA that are deleted or duplicated. Previously it was assumed that these variations only occurred in cases of disease, such as cancer. The mosaic that we've seen in the skin could also be found in the blood, in the brain, and in other parts of the human body."

The longstanding belief has been that our cells have the same DNA sequence and this blueprint governs the body's functions. The Yale team's research challenges this dogma. Some scientists have hypothesized that during development, when DNA is copied from mother to daughter cells, there could be deletions, duplications and changes in the sequence of the DNA, and an entire group of genes could be affected. This premise has been incredibly difficult to test, but Vaccarino and colleagues have done so in this new study.

The team used whole genome sequencing to study induced pluripotent stem cells lines (iPS), which are stem cells developed from a mature-differentiated cell. The team grew cells taken from the inner upper arms of two families. The team spent two years characterizing these iPS cell lines and comparing them to the original skin cells.

While observing that the genome of iPS cells closely resembles the genome of skin cells from which they originated, the team could identify several deletions or duplications involving thousands of base pairs of DNA. The team then performed additional experiments to understand the origin of those differences, and showed that at least half of them pre-existed in small fractions of skin cells. These differences were revealed in iPS cells because each iPS line is derived from one, or very few, skin cells. Vaccarino said these iPS lines could act as a magnifying glass to see the mosaic of genomic differences in the body's cells.

"In the skin, this mosaicism is extensive and at least 30 percent of skin cells harbor different deletion or duplication of DNA, each found in a small percentage of cells," said Vaccarino. "The observation of somatic mosaicism has far-reaching consequences for genetic analyses, which currently use only blood samples. When we look at the blood DNA, it's not exactly reflecting the DNA of other tissues such as the brain. There could be mutations that we're missing."

"These findings are shaping our future studies, and we're doing more studies of the developing brains of animals and humans to see if this variation exists there as well," Vaccarino added.

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Skin cells reveal DNA's genetic mosaic

McCabe Genetics 1071
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Genetics of Bipolar Disorder - Recovery May Be Possible
Bipolarecovery.wordpress.com This is a presentation on genetic causes for bipolar disorder from the standpoint of the bipolar individual who wishes to recover. Unfortunately, genetic causes would likely be incurable. However, such causes are currently only "beliefs", not "facts". Thus, it is logical to conclude that recovery may be possible. The goal of this video is to show that there is still hope for those who wish to fully recover from bipolar disorder. If there are no genetic causes, then this so-called illness may actually be something that can be cured.From:IanReynirViews:1 1ratingsTime:07:52More inEducation

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Genetics of Bipolar Disorder - Recovery May Be Possible - Video

McCabe Genetics 164
From:Flinton McCabeViews:0 0ratingsTime:00:22More inPets Animals

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McCabe Genetics 164 - Video

The Reason I #39;ve Been Gone
Hey friends ... Not long ago the Alf got his home broken into.. Everything was lost and I haven #39;t had the heart to post a video, but I got love for all my great friends out there.. So this is the reason I #39;ve been away.. We got a small bit of life found from outside. Update to follow.. In life friends, you #39;ll have bad people flock to good hearted souls, especially if your a caregiver.. Sucks people can #39;t just ask for help they have to thief and take parts of people #39;s life #39;s they will never get back.. 10 years of genetics collected gone in a moment.. And most likely in a trash pile someplace, cause it didn #39;t mean a damn thing to them.. Sorry for the rant.. But just feel comfortable enough to share with ya.. Stay green AlfFrom:PlanetGreenToeViews:16 1ratingsTime:00:52More inEducation

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New geneticS
Runnin Humboldt seed org #39;s Blue Dream and Sour Diesel #2. TGA #39;s Dairy Queen, THSeeds Darkstar. Also phono hunting seven different Mr. Nice females...(Sensi Seeds) should be good! 1080p sorry for the blinding HPS, picking up some Method 7s asap In compliance with my states medical mmj laws. All legal medicineFrom:TheRealLuMpKiNgViews:9 4ratingsTime:08:26More inNonprofits Activism

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Lysenkoism - Wiki Article
Lysenkoism, or Lysenko-Michurinism was the centralized political control exercised over genetics and agriculture by Trofim Lysenko and his followers. Lysenko was the director of the Soviet Lenin All-... Lysenkoism - Wiki Article - wikiplays.org Original @ http All Information Derived from Wikipedia using Creative Commons License: en.wikipedia.org Author: Duncharris Image URL: en.wikipedia.org ( This work is in the Public Domain. )From:WikiPlaysViews:0 0ratingsTime:15:26More inEducation

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Luna Genetics - Spinal Fluids
Psy-trance track I made around 2003-04.From:acidperplexerViews:0 0ratingsTime:03:32More inMusic

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Luna Genetics - Spinal Fluids - Video

Humans Getting Dumber Emotionally Intellectually As Species?
GO TO: goo.gl Please watch the HILARIOUS videos in this play list, read the rest of this too please. "Study suggests humans are slowly but surely losing intellectual and emotional abilities" November 12th, 2012 in Genetics In the following article, please replace the word "evolution[ary]" with "natural selection", thank you. If you have noticed the same trend, now you know others have too. Please read the entire article, as there is a silver lining, just as GD would have it of course. Human intelligence and behavior require optimal functioning of a large number of genes, which requires enormous evolutionary pressures to maintain. A provocative hypothesis published in a recent set of Science and Society pieces published in the Cell Press journal Trends in Genetics suggests that we are losing our intellectual and emotional capabilities because the intricate web of genes endowing us with our brain power is particularly susceptible to mutations and that these mutations are not being selected against in our modern society. "The development of our intellectual abilities and the optimization of thousands of intelligence genes probably occurred in relatively non-verbal, dispersed groups of peoples before our ancestors emerged from Africa," says the papers #39; author, Dr. Gerald Crabtree, of Stanford University. In this environment, intelligence was critical for survival, and there was likely to be immense selective pressure acting on the genes required for intellectual development ...From:roboecoViews:16 0ratingsTime:01:14More inEducation

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Humans Getting Dumber Emotionally

Minecraft Mods Episode 433 GENETICS iPodmail 1 2 5 YouTube
Download your copy from here (Limited Time Only) http://www.mediafire.com Minecraft cracked server 1.4, NO hamachi is required to join this minecraft server. Lag Free! IP below! Tons of mods, area protections, locked chests, NPC, antigrief, giants, bonus drops, random drops, etc Lot #39;s of things are going on in this minecraft server! We have players from all over! USA, Holland, Canada, Australia, UK, etc You will have to ro sign up on the forums and post your in game name to the correct forum thread to play. Update. Sorry people. Bonuscraft server is closed. Minecraft cracked server 1.4, NO hamachi is required to join this minecraft server. Lag Free! IP below! Tons of mods, area protections, locked chests, NPC, antigrief, giants, bonus drops, random drops, etc Lot #39;s of things are going on in this minecraft server! We have players from all over! USA, Holland, Canada, Australia, UK, etc You will have to ro sign up on the forums and post your in game name to the correct forum thread to play. Update. Sorry people. Bonuscraft server is closed.From:minemaincraft1Views:0 0ratingsTime:02:42More inGaming

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Crested Gecko Genetics
some things about crested gecko geneticsFrom:Reptile KidViews:0 0ratingsTime:06:41More inPets Animals

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Genetics - three20south
November 16, 2012 Sneakin Otto Through The GrottoFrom:GeneticstunesViews:1 0ratingsTime:21:16More inMusic

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Generic Genetics, Gaming PC and DAD #39;S OKAY! (UABP vlog 5)
Derp. Herpidy derp, derp. Derp. That is all for the description (that isn #39;t copy and pasted from all the others) Please leave a comment of what you think about it, I love replying to your opinions! Your support is both greatly needed and greatly appreciated! And share me my lovely UABPians! under-a-blue-pen.co.uk that #39;s where I keep all my short stories, you can request one for me to write for you, honestly I like doing it 🙂 Facebook: http://www.facebook.com Twitter: twitter.com Gmail: underabluepen@gmail.comFrom:UABPViews:0 0ratingsTime:11:12More inPeople Blogs

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Generic Genetics, Gaming PC and DAD'S OKAY! (UABP vlog 5) - Video

The Forever Family
There are many ways to define the word "family." For some, it #39;s a bond based on shared genetics or a last name. For the Wallin family, it #39;s much more than that. Aired Nov. 15, 2012 on WKBT News 8.From:JennaTroumReporterViews:0 0ratingsTime:04:29More inPeople Blogs

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Viral Vectors Genetics Project
Wolfmother - Joker and the TheifFrom:D SchwartzViews:3 0ratingsTime:01:36More inScience Technology

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Viral Vectors Genetics Project - Video