Archive for the ‘Hormone Clinic’ Category

Yes. Yes, probiotics have the potential to improve a persons sex life.

Whether or not they have the potential to improve your sex life, however, depends on your current gut health and your sex life.

When we talk about gut health, were typically talking about the composition of the billions of bacteria, archaea, and fungi inside the gut.

This is known as the microbiome, and it affects all sorts of things that contribute to your interest in sex and overall sexual satisfaction.

Did you know that the majority (about 95 percent!) of serotonin the happiness hormone in the body is produced in the gut? Yep!

But for the optimal amount of serotonin to be produced, the gut has to be in tip-top shape. When the gut is in suboptimal health, your serotonin and overall happiness levels can dip.

And according to Dr. Anna Cabeca, triple-board certified OB-GYN and author of The Hormone Fix: Low serotonin is associated with lower sex drives.

Makes sense. Few of us are jonesing to do anything in the sack other than sleep when were sad.

Belly bacteria helps create B vitamins, which are essential for the production of ATP (science-talk for energy). Less B vitamins = less energy.

Plus, some of the bacteria communicate with other cells in charge of blood sugar regulation, says Anthony Thomas, PhD, nutrition researcher and director of scientific affairs with probiotic brand Jarrow Formulas.

If your gut bacteria gets out of whack, your blood sugar levels can crash more easily. This can lead to more and longer lasting energy dips.

So, that too tired for sex feeling? Well, it might be linked to your gut health in more ways than one.

Fun fact: Serotonin is found in the genitals. Seriously!

Some research suggests that when your serotonin levels dip, your physical response to sexual feelings dips, too.

When our gut microbiome is unhealthy, it can lead to inflammation, says Dr. William W. Li, a physician, scientist, and author of Eat to Beat Disease: The New Science of How Your Body Can Heal Itself.

Sadly, inflammation is quite the c*ck-block.

For example, some research has found that sexual health dysfunction is common among folks with inflammatory arthritis.

Lets face it: Its pretty damn hard to be in the mood to bone when you cant leave the bathroom.

And there are certain gut conditions that cause bathroom troubles to rear their ugly heads. These include:

In addition to constipation and diarrhea, other common symptoms include:

Both the physical and emotional effects of these and other gastrointestinal (GI) conditions have the potential to affect your sex life.

The keyword here is potential.

If youve already received a diagnosis or suspect that your symptoms might be a sign of a GI condition, talk with a doctor or other healthcare provider about your concerns.

They can help you find the best management or treatment option for your individual symptoms or side effects.

By now you can probably tell that your microbiome is complicated. Well, so is your libido.

Libido in general is very complicated and is impacted by many different things, says Cabeca. Hormones, lifestyle, and relational factors also have to be considered.

So finding out if your libido fluctuations are related to your microbiome is similarly tricky. And no matter how well-intentioned, gut health mishaps can have a direct effect on your overall health.

Li recommends meeting a gastroenterologist, the medical specialist that focuses on the gut, if youre experiencing any of the below symptoms:

Note: That recommendation stands even if your libido isnt funked up.

A gastroenterologist will be able to recommend an endoscopy, colonoscopy, or a scan of your abdomen to find out whats up, explains Li.

They also may be able to check your microbiome for abnormalities by sending a stool sample for testing, he adds.

Please dont self-diagnose your gut symptoms or libido mishaps. Why? Well, because theyre both incredibly complex.

Dr. Kimberly Langdon, OB-GYN and medical advisor at telehealth provider Medzino, notes that mental health conditions like depression are often linked with low libido.

In these cases, for example, trying to course correct at home without talking to a healthcare provider may mean delaying access to helpful medications or other necessary treatment.

Many GI conditions are characterized by dysbiosis, which is medical speak for an imbalance of bacteria in your gut.

If your provider has diagnosed dysbiosis, Li says that probiotics helpful yeasts and bacteria often delivered via certain foods and supplements may help.

A word of caution: Not all probiotics are created equal.

As a general rule, probiotics that are stored in the refrigerator are higher quality than those stored on the shelf.

Cabeca adds that Lactobacillus strains are typically better than others.

Bacterial imbalance has been linked to increased inflammation, so its thought that probiotics may help alleviate symptoms associated with IBS, IBD, and other inflammatory conditions.

Probiotics may also be helpful for acute digestive conditions like gas, bloating, constipation, and diarrhea.

All that said, even if everything above sounds similar to your situation, you shouldnt start or increase your probiotic intake without first talking with a doctor or other healthcare provider.

There are two good reasons for this:

For example, if someone has small intestinal bowel overgrowth, adding probiotics can worsen gas and other symptoms, explains Cabeca.

If youve ever been probiotic shopping, youve likely stumbled across probiotics marketed for vaginas theyre all the rage, after all.

According to Langdon, these probiotics typically contain higher levels of Lactobacillus. Some research suggests that Lactobacillus helps support a healthy vaginal pH, as well as keep other pathogens at bay.

Now, if you scroll back up to the previous section, youll notice that Lactobacillus is the strain of bacteria thats best for both improving overall gut health and supporting vaginal health.

Thats why Li says, its just a marketing ploy. These probiotics are no different than any other probiotics on the market.

So do probiotics marketed for your genitals actually work? If you have a condition that can be remedied by consuming more Lactobacillus, they may.

But dont be tricked into thinking these probiotics are a one-stop solution for sexual dysfunction or the only option available.

Yep! In fact, there are quite a few things you should consider using in tandem or even instead of, in some cases.

Thats because (again, for the people in the back!) gut and sexual health conditions arent quick-fix problems.

The meds and antibiotics youre on or have been on can affect your gut microbiome, explains Thomas.

Its also widely known that antidepressant, antipsychotic, anti-epileptic, blood pressure, and cholesterol lowering meds can all impact sexual functioning.

Thats why Thomas recommends making sure your doctor knows what meds youre currently taking so they can help you troubleshoot if need be.

For gut conditions, most experts will recommend a diet shift, at least for a short period of time.

Cabeca, for example, recommends folks follow a healthy elimination diet to better understand what foods lead to their gut unrest. She also recommends incorporating gut-healing foods like bone broth and fermented veggies.

Regular exercise has been linked with higher serotonin levels.

Given serotonins relationship to both your gut and sex life, if youre currently on the sedentary side of things, moving your body more may be helpful.

If you have a condition that can be helped with a probiotic, Cabeca says, often, you can see a significant improvement of symptoms after 21 days.

And that includes symptoms related to your sex life.

Thomas, however, notes that probiotics need to be taken regularly. Benefits may ease if supplementation is discontinued, he adds.

Probiotics arent a one-size-fits-all treatment for all folks experiencing gut conditions or sexual dysfunction. But for some, they can be an incredibly beneficial part of a holistic treatment plan.

Gabrielle Kassel is a New York-based sex and wellness writer and CrossFit Level 1 Trainer. Shes become a morning person, tested over 200 vibrators, and eaten, drunk, and brushed with charcoal all in the name of journalism. In her free time, she can be found reading self-help books and romance novels, bench-pressing, or pole dancing. Follow her on Instagram.

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5 Ways Gut Health Affects Your Sex Life and How Probiotics Can Help - Healthline

According to a now-viral TikTok video posted on Dec. 8, 2020, as much as 95% of serotonin a key neurotransmitter that plays a role in regulating mood may be produced in the gastrointestinal tract:

#edutok #fyp #foryoupage #gut #serotonin Psychology #ThinkingAbout #til #discover

original sound Gianu System

The bacteria in your gut produce about 90% of the serotonin in your body, said social media user gianusystem, a self-identified online community dedicated to bringing awareness to dissociative identity disorder, or multiple personality disorder. The woman goes on to cite an article in Discover Magazine, adding that she was skeptical of new information that she hadnt heard before.

So, I went and looked this up. Thats the low number, said in the video, which at the time of writing had been shared more than 20,500 times.

Snopes also looked up the information and found that the claim is mostly true: Estimates suggest that up to 95% of the serotonin in the body is released in the gut through certain intestinal cells. But there is an important caveat to note: Most studies that link serotonin production to the gastrointestinal system have been conducted in animals. According to an article titled Gut Bacterias Role in Anxiety and Depression: Its Not Just in Your Head, which appeared in the November 2020 issue of the science magazine Discover, author Elizabeth Svoboda reported that about 90% of serotonin produced in the human body is done so in the gut.

Serotonin is a hormone and neurotransmitter responsible for sending chemical messages between cells to play a key role in stabilizing mood, feelings, and happiness. In the brain, serotonin allows cells of the nervous system to communicate with one another and when too little serotonin is produced, a person may experience anxiety, depression, and other emotional and behavioral disorders. Such conditions are typically treated with selective serotonin reuptake inhibitors (SSRIs), or antidepressants, that the Mayo Clinic said work by increasing levels of serotonin by blocking the reuptake of serotonin into some neurons, making the hormone more available to improve the transmission of messages.

While serotonin is most well-known for its role in the brain, the hormone is also found in the stomach and intestines where it helps to maintain bowel movements and function, noted the Hormone Health Network, an affiliate of the Endocrine Society. And some researchers postulate that a greater understanding of serotonin production in the gut may inform the treatment of certain mental health conditions in the brain.

In 2015, researchers at the California Institute of Technology demonstrated that bacteria normally present in the gut can stimulate the intestinal cells to produce serotonin as much as 90% of which is made in the digestive tract. In mice, a particular mixture of bacteria also found in the human gut produced molecules that signaled to gut cells to increase the production of serotonin. Modified mice that did not have the bacteria had more than 50% of their gut serotonin missing. Adding that bacterial mixture which contained Turicibacter sanguinis and Clostridia increased serotonin back to a normal level. Though the study was conducted on mice, the scientist wrote in the journal Cell that the findings lend important insight into how the gut microbiome can influence the nervous system.

Four years later, those same researchers set out to inform how the 100 trillion or so bacteria and hormones that live in the human intestinal system may produce serotonin. This time around, researchers added serotonin to the drinking water of some mice and raised others with a mutation that increased the levels of serotonin in their guts. An analysis of the mice microbiota showed that the presence of T. sanguinis and Clostridia increased significantly when there was more serotonin in the gut. As part of the study, mice were also given fluoxetine, or Prozac, which was shown to block the serotonin transporter in the T. sanguinis, which slowed the transport of serotonin.

Previous studies from our lab and others showed that specific bacteria promote serotonin levels in the gut, said study author Thomas Fung at the time in a news release. Our new study tells us that certain gut bacteria can respond to serotonin and drugs that influence serotonin, like anti-depressants. This is a unique form of communication between bacteria and our own cells through molecules traditionally recognized as neurotransmitters.

So while it is true that a large proportion of the bodys serotonin is produced in the guts and serotonin-targeting drugs can have a major effect on the guts microbiota the exact mechanisms behind the production are not yet known. Furthermore, it is important to consider that many of the studies have been conducted on mice and not necessarily in humans.

Regardless, because most treatments for depression deal with serotonin receptors in the brain, understanding how and where the hormone is produced may help to inform future treatments into emotional and behavioral disorders such as anxiety and depression.

Read the original post:
Is 90% of Serotonin Found in the Gut? - Snopes.com

Medication abortion usestwo types of pills: mifepristone, which interrupts the flow of the hormone progesterone that sustains the pregnancy; and misoprostol, which causes contractions to expel the contents of theuterus. (VAlaSiurua, licensed underCC BY-SA 4.0)

This post originally appeared in the Hampshire Gazette. It has been republished with permission.

The COVID-19 pandemic is transforming many aspects of our lives, and abortion is no exception. Telemedicine is expanding access to abortion health care in ways that are likely to persist long after the pandemic is over.

Telemedicine abortioncombinesmedication abortionwhich uses pills to end a pregnancyandtelemedicinewhich allows health providers to supervise the use of abortion pills via videoconferencing or telephone consultations.

Approved by the FDA for use during the first 10 weeks of gestation, medication abortion usestwo types of pills: mifepristone, which interrupts the flow of the hormone progesterone that sustains the pregnancy; and misoprostol, which causes contractions to expel the contents of theuterus.

This combination of pills is 95 percent effective and is anextremely safe wayto end an early pregnancy. In fact, medication abortion accounts for over 60 percent of abortions in the first 10 weeks, according to the Guttmacher Institute.

Despite the safety of medication abortion, politically-motivated restrictions on mifepristone have blocked easy access to the pill. After years of anti-abortion resistance, the FDA approved the drug in 2000, but placed it in the Risk Evaluation and Mitigation Strategy (REMS) drug safety program. Under this restriction, the FDA prohibited retail pharmacies from stocking and distributing mifepristone, insteadrequiringdoctors to register with the drug manufacturer and distribute the medication themselves in person to patients, who then take most of the pills at home.

Whereas the REMS program is meant to restrict dangerous drugs, mifepristone is in fact anextremely safe drugsix times safer than Viagra, which is not similarly restricted.This FDA restriction was based on politics,not medical evidence.

Here atMs., our team is continuing to report throughthis global health crisisdoing what we can to keep you informed andup-to-date on some of the most underreported issues of thispandemic.Weask that you consider supporting our work to bring you substantive, uniquereportingwe cant do it without you. Support our independent reporting and truth-telling for as little as $5 per month.

Earlier this year, the American College of Obstetricians and Gynecologists (ACOG) and SisterSong Women of Color Reproductive Justice Collective brought a lawsuit challenging the FDA requirement of an in-person appointment for patients to receive the abortion pill during the pandemic.

In July,a Maryland federal courttemporarily suspended the requirement. The Trump administration challenged the decision but it was upheld earlier this month. Reproductive rights advocates are now pressing Biden to ask the FDA to review and permanently remove the REMS restriction on mifepristone.

The other barrier to telemedicine abortion is the standard medical protocol that recommends an ultrasound to determine the number of weeks a patient is pregnant and an Rh blood test, which require an in-person visit. On March 30, 2020, however, ACOG issuedguidance stating that an ultrasound and Rh testing are often not necessary because patients can reliably tell their doctors when their last period began and their blood type. The new no-test medication abortion protocol eliminates the need for in-person visits and tests in most cases.

As a result of the lawsuit lifting the FDA restriction on medication abortion and the new no-test medical protocol, telemedicine abortionstartups are springing up across the country. These new virtual clinics screen patients remotely, then mail abortion pills to them, often using newonline pharmacies. In total, 20 states and Washington D.C. now offer legal access to telemedicine abortion from doctors within their state.

These startups are revolutionizing abortion care by offering convenient services, especially for people living in rural areas far away from reproductive health clinics. They are also making abortion health care more affordable. Whereas in-clinic care with testing can cost $500-700, telemedicine abortion costs as little as $95.

Another advantage of medication abortion is that patients can take the pills immediately after missing a period: they dont have to wait until a fetus is visible on an ultrasound (approximately 6 weeks). In fact, some health care providers are prescribing medication abortion as missed period pills, without requiring a pregnancy test, which some patients prefer.

The organization Plan C has a comprehensivewebsiteat plancpills.org with information on medication abortion. The website includes all the new avenues for pill access that now exist in the US, including telemedicine services, online pharmacies, and reliable websites selling the abortion pill from abroad. Searchable by state, the website offers patients information about all of their options wherever they live, as well as information about financial support, legality, and legal resources. Plan C also offers atoolkit for medical professionalswith a step-by-step guide on how to become a medication abortion provider.

Many people choose telemedicine abortion because it is more private and convenient than in-clinic medication abortion or procedural abortion by aspiration. Instead of having to drive to a provider and wait hours for an office visit, missing work or paying for child care, you can have your appointment from wherever you are without waiting, and take the pills when its convenient, like over the weekend or on your day off. Especially in states with few abortion clinics, or where protesters yell and scream at women entering reproductive health clinics, telemedicine abortion can increase access and reduce the stress of accessing abortion health care.

I suspect that these COVID-inspired innovations in abortion health care will persist beyond the pandemic. The cat is out of the bag. The obstacle course of expensive, burdensome and delayed abortion care should be a thing of the past. Accessible, affordable, early abortion care is possible. We just need the political will to make it happen.

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Telemedicine Is Revolutionizing Abortion Health Carein Ways Likely To Persist Long Past COVID - Ms. Magazine

VERU-111, a next-generation form of chemotherapy, has shown promising signs of efficacy as a treatment option for men with metastatic castration-resistant prostate cancer (mCRPC) whose disease has progressed while receiving androgen receptor (AR)-targeting therapy.

Investigators are planning a phase 3 trial that will test VERU-111 against an alternative AR-blocking agent in men with mCRPC who have developed resistance to abiraterone acetate (Zytiga) or enzalutamide (Xtandi), which typically are administered in this treatment setting (Figure). Veru Inc, the company developing the agent, plans to launch the trial during the first quarter of 2021, pending discussions with the FDA.1

Figure. Proposed Phase 3 Trial of VERU-111 in mCRPC

VERU-111 is an oral therapy that binds to the colchicine binding site on the microtubule to crosslink and tubulin, thus inhibiting microtubule polymerization. Preclinical findings show that the agent induces apoptosis in taxane-resistant and enzalutamide-resistant CRPC cell lines.2

Findings from a phase 1b/2 study (NCT03752099) showed that daily chronic administration of VERU-111 was feasible and safe in men with previously treated mCRPC, according to data presented at the European Society for Medical Oncology (ESMO) Virtual Congress 2020.2

Investigators enrolled 39 patients across 7 sites in the United States. Eligible men with mCRPC had to have received 1 prior AR-targeted therapy; those who had received 1 line of taxane-based chemotherapy for mCRPC were included. The median age of participants was 74 years (range, 61-92), the median Gleason score was 8 (range, 5-10), and 95% had ECOG performance status scores of 0 or 1.2

In the first part of the study, investigators tested a 2-part dosing schedule using a standard 3 x 3 dose-escalation strategy across 10 dosing levels ranging from 4.5 mg to 81 mg daily. The recommended phase 2 dose was established as 63 mg daily.2

Outcomes were reported for a subset of 10 men who received VERU-111 monotherapy continuously at the recommended dose for 4 or more cycles. Of these patients, 6 had a decrease in prostate-specific antigen (PSA) levels, including 4 with a decrease of 30% or more and 2 with a decrease of 50% or more. The best objective tumor response comprised 2 patients with partial responses and 8 with stable disease. The median duration of treatment without radiographic progression was more than 11 months (range, 6-17) and half of the 10 men remained on study therapy at the time of presentation.2

Additionally, investigators presented results from 1 patient, an 88-year-old man with Gleason 9, node-only mCRPC who had previously received sipuleucel-T (Provenge), enzalutamide, and abiraterone. After VERU-111 therapy, a CT scan showed a 33% decrease in size to a nonpathologic node.2 Further, the patient experienced a 63% reduction in PSA level within the first cycle of treatment and remained in the study for over 16 months.

In the safety population of 25 patients who had been treated with the recommended dose for at least 1 cycle, the most frequently observed drug-related adverse effects (AEs) included diarrhea (56%), nausea (24%), and decreased appetite, fatigue, dysgeusia, and weight loss (all, 12%). Most AEs were of grade 1 or 2 severity. An instance of fatigue that was resolved with a dose reduction was the only drug-related AE of grade 3 or worse at the 63-mg dose. Investigators did not record any reports of neurotoxicity in the study and no incidence of neutropenia at the 63-mg dosing level.2

The trials early findings are generating interest among experts in prostate cancer. One impressive aspect of this study was the PSA declinations of 50% or more, said Neal D. Shore, MD, medical director of Carolina Urologic Research Center in Myrtle Beach, South Carolina, in an interview with OncLive.

Shore said VERU-111s oral route of administration could make it an attractive choice compared with traditional taxanes such as docetaxel and cabazitaxel (Jevtana), which are given intravenously. Especially during the time of a pandemic, one recognizes the advantage for using an oral medication not requiring a clinic visit for administration, he said. The oral-based delivery may also appeal to clinicians who are not offering infusions within their clinics.

Oral delivery of a taxane or microtubule- or tubulin-inhibitor mechanism of action would be a significant addition to our therapeutic armamentarium, Shore added.

Although microtubule-targeting agents (MTAs), including taxanes and vinca alkaloids, are effective and widely used for treating a variety of cancers, resistance and toxicity can limit their clinical efficacy. In prostate cancer, resistance also builds up in patients who receive AR-targeting therapies. Approximately 15% to 25% of men do not respond to AR inhibitors and 75% to 85% progress within 9 to 15 months.3

Furthermore, as AR-targeting agents such as enzalutamide, darolutamide (Nubeqa), apalutamide (Erleada), and abiraterone are approved for earlier lines of treatment, patients with metastatic disease who progress on these agents need new options, according to Philip W. Kantoff, MD, chair of the Department of Medicine and George J. Bosl Chair at Memorial Sloan Kettering Cancer Center in New York, New York.

According to Kantoff, a 2014 Giants of Cancer Care award winner in the genitourinary cancer category, novel therapies such as VERU-111 may allow patients to overcome acquired resistance to AR inhibitors. Androgen-blocking agents are either introduced in the context of metastatic hormone-sensitive prostate cancer, nonmetastatic CRPC, or mCRPC, he said in an interview with OncLive. It is leaving a void where we dont have many drugs right now, so there is still a need for new therapies in mCRPC.

The phase 2 portion of the study reported at ESMO 2020 is fully enrolled with 40 patients, Veru announced in September.4 The open label, single-arm trial will evaluate VERU-111 for efficacy and safety in patients who have become resistant to at least 1 AR-targeting therapy but who have not received intravenous (IV) chemotherapy in the metastatic setting. The key efficacy end point of the phase 2 portion is radiographic imaging of progression-free survival (rPFS).

Looking ahead, Veru is making plans for a phase 3 trial that would enroll 250 men with mCRPC who have rising PSA levels and tumor progression while receiving AR-targeting therapy. Participants would be randomized to receive either VERU-111 continuously at 63 mg daily or standard therapy with either abiraterone or enzalutamide, depending upon their prior treatment. The primary end point would be rPFS, with secondary end points of overall survival, time to IV chemotherapy, pain progression, and PSA responses.5

VERU-111 also has demonstrated antitumor activity in preclinical models of other tumor types, including taxane-resistant triple-negative breast cancer and lung cancer, pancreatic cancer, and melanoma.5 Additionally, the agent is currently undergoing testing as a potential treatment for coronavirus disease 2019 (COVID-19) in a phase 2 trial (NCT04388826). Investigators are seeking to randomize 40 patients with COVID-19 who are at high risk for acute respiratory distress syndrome to either 18 mg of VERU-111 or placebo. The primary efficacy end point for the 62-day study is the proportion of patients alive and without respiratory failure at day 29.

More:
Next-Generation Cytotoxic Therapy Moves Forward in mCRPC - OncLive

50 N. Medical Drivetransgenderhealth@hsc.utah.edu801.213.2195 | uofuhealth.org/transhealth

At the core of each story in SLUGs My Body and Me issue lies the powerful force of bodily autonomy. Here, Ariel Malan, the Program Coordinator of the Master of Healthcare Administration and the Transgender Health Program at the University of Utah, talks the physical, social and emotional changes surrounding this identity-affirming body transformation.

SLUG: Can you please fill us in on the history of the Transgender Health Program? How has it changed/grown since its inception?

Malan: Thanks to the work of several dedicated healthcare providers, our Program was officially launched in 2017. Prior to this date, many meetings were held between providers and hospital leadership about the need for more coordinated care for transgender and gender-diverse patients. Since then, we have seen volumes dramatically increase across all of our specialties. We believe that this is predominantly due to the fact that there has been a gap in providing this care to patientsnot just in Utah, [but] across the nation. We are the only multidisciplinary program in the Mountain West, and although we serve primarily Utahs communities, we also see 12% of our patients from other states.

In addition to our growth, we have defined our mission and vision to better serve our communities and continue to hold the Program and our University system accountable for health outcomes:

Vision (where we are going): A patient-centric, multi-disciplinary gender health program for all gender journeys across the lifespan.

Mission (what we do): The Transgender Health Program is committed to providing comprehensive, compassionate, evidence-based care for gender-diverse individuals in a supportive, affirming environment.

Intersectionality: We will recognize the unique social and political identities that exist within gender-diverse individuals and advocate to remove inequalities within healthcare.

Coordinated Care: We will provide coordinated care through patient navigation and provider communication on all aspects of care.

Research: We will engage in research to advance knowledge and well-being for the care of gender-diverse individuals.

Education: We seek to educate providers, trainees and the public on the needs and health of gender diverse individuals.

SLUG: What are the range of services offered at the Program?

Malan: Our Program spans across eight different specialties that coordinate care for all gender-affirming services a patient might need on their gender journey. Patients and families can access the [following] range of services at our website, uofuhealth.org/transhealth: primary care and HRT, plastic surgery, fertility and family planning, voice therapy, physical therapy, laser hair removal, adolescent medicine [and] gynecologic care.

SLUG: Can you please elaborate on the range of staff at the Program? What types of professionals are available?

Malan: Currently, we have three dedicated administrative staff to our Program. This includes two Patient Coordinator roles that assist patients in navigating care and scheduling appointments, and a Program Coordinator role that manages marketing and outreach, education, strategy and other programmatic projects.

Our clinical staff is not dedicated to our Program alone in that they serve in multiple capacities. For example, we have plastic surgeons that are specially trained in gender-affirming surgery, but they also deliver other types of plastic surgery to patients that are not our transgender patients. The range of professional clinical positions include physical therapists, plastic surgeons, family-medicine providers, speech-language pathologists, endocrinologists, adolescent medicine physicians, aestheticians, physician assistants, reproductive specialists, OBGYNs and urologists.

We have high hopes that our hospital system will continue to support us in providing us with more dedicated positions both clinical and administrative.

SLUG: I read in your FAQ a bit about opening up your services to be more inclusive toward nonbinary identities and others. Can you please elaborate on the types of changes the Program is undertaking in this regard?

Malan: Transgender is an umbrella term that encompasses many gender-diverse identities, including those who identify as nonbinary. Its important that our Program is able to serve all of these identities by not assuming what someones gender journey looks like based on how they identify. This is why all of our providers consider every patients journey as unique and discusses with them what options exist. Not all transgender people pursue medical transition, and some are only interested in a handful of gender-affirming options.

We are working closely with our new Patient and Family Advisory Board to identify ways that our Program can be more inclusive to gender fluid/nonbinary identities.

SLUG: I saw a section on your website regarding events. While those are (likely) on pause right now, what are the types of events that the Program typically holds or appears at?

Malan: Many of the events we offer are educational either for patients or providers. Every month, we offer a patient-education seminar on various transgender health topics. Our providers are present to talk about the services and what to expect, and we offer a panel of patients who have had that particular service. This is free and open to the community to attend and ask questions. Since COVID, we have hosted these virtually via Zoom and will continue to do this until it is safe to resume back in person. [In these cases,] these are offered at the Utah Pride Center. Patients can visit uofuhealth.org/seminartransgenderhealth to see a list of upcoming seminars.

For our providers, we hosted our first annual conference on transgender health this year and plan to offer this and more educational offerings to community providers.

SLUG: In addition to the medical services you offer, it seems like there are a lot of other areas (counseling, voice therapy, etc.) deal with more intangible things. Can you please talk about how these areas interact with things such as surgeries, hormones, etc.?

Malan: For many of our patients, counseling or mental-health therapy may be their first point of contact in a healthcare system in talking about their gender journey. For many folks in the beginning of their journey, they may still be in whats called their social transition, finding what is most authentic to them in their own expression through body language, adjusting their voice, changing hair or clothing styles, or a legal name change.

These are reversible and fluid things that people are figuring out for themselves, so medical and surgical changes may or may not be on their list to pursue.

An unfortunate barrier that still exists to this day in accessing gender-affirming medical and surgical options are the WPATH (World Professional Association for Transgender Health) requirements. Although these guidelines provide evidence-based practices for providers offering these services, there is a list of criteria, including living in your desired gender role for at least one year, before many things can happen. These guidelines can be interpreted loosely by providers to make sure patients get the care they need, but health-insurance companies sometimes have stricter standards they go by in order to cover any services that someone may need as part of their journey.

SLUG: A significant offering at the Program are the youth and teen Transgender Health Services. Can you please elaborate on the breadth of these services and their place in the Transgender Health Program?

Malan: More and more youth are identifying under the transgender umbrella, so the services offered at our Adolescent Medicine Clinic, [such as the] Gender Management and Support are critically important for families and youth.

We have physicians who specialize in adolescent transgender medicine [and] can provide options for puberty blockers, hormone therapy, behavioral health and nutrition wellness, and coordinate care with our adult providers so the transition to those services can be seamless.

SLUG: How does the Transgender Health Program interact with other aspects of the Utah LGBTQ+ community?

Malan: We are heavily reliant [on] and grateful our community partners. We cannot do the work we do without their help and feedback. A couple of our community partnerships include:

Genderbands: Every year we partner with Genderbands to offer a top surgery grant for those who are uninsured in the community.

Utah Pride Center: Pre-COVID, we used their space to offer our patient-education seminars and refer patients to them for their mental health services and support groups. Every year, we also participate in the annual Utah Pride Festival and Genderevolution conference.

We have been present at many other community organization events through outreach booths, presentations and referring patients directly to them for resources. As mentioned previously, we also have created our own Patient and Family Advisory Board made up of community patients and family members They are helping us shape the strategy and direction of our Program, which will ensure our services are patient-centric.

SLUG: Whats one thing youd like the readers to know about the work you do and the communities you work with?

Malan: We are a new and growing Program! This means that we have a long way to go in making sure our Program is remedying the historical trauma that our community has experienced directly by healthcare providers. But this also means we have many exciting opportunities to engage with our community and integrate their feedback into how we provide these services. For our allied healthcare providers, we hope to be a resource in providing education for you and your staff to better serve transgender patients. For our patients, we thank you for your continued vulnerability during our growth and aim to be [a] safe space that can meet your healthcare needs.

SLUG: If a reader is interested in obtaining services, how can they get in touch or schedule an appointment?

Malan: Call us directly at 801.213.2195, option 1, and leave us a voicemail. We receive many phone calls a day, so leaving a voicemail will make sure we can get back to you. Also, emailing us at transgenderhealth@hsc.utah.edu.

SLUG: What does the Transgender Health Program have planned for the future?

Malan: So many things! We are looking forward to creating our first five-year business plan, which will include direct patient feedback from our Advisory Board, and both clinical and administrative input on ensuring the sustainability of our services. We also are launching our first educational-needs assessment that will guide us in delivering needs-based education on LGBTQ+ communities to our providers and staff. A few others to mention: a community photoshoot to use representative photos of our community marketing materials; improving the accessibility of our patient education seminars and other patient education materials; identifying our underserved communities so we can better reach them; creating a development plan to bring fundraising dollars into the Program to fund important initiatives like scholarships for patients and research; work toward requiring standardized education for our system on LGBTQ+ people and get all of our inpatient facilities designated under the Healthcare Equality Index.

Find here a list of additional local resources for transgender individuals, compiled with the invaluable assistance ofRiver Jude August:

Read the original:
Transgender Health Program at the University of Utah - SLUG Magazine

Premature menopause is the permanent end of menstrual periods before age 40. It occurs because the ovaries no longer release eggs (ovulation) regularly and become less able to produce hormones.

Some women have no symptoms except being unable to become pregnant, and others have the same symptoms as those of natural menopause (such as hot flashes or night sweats). To become pregnant, women with premature menopause can have eggs from another woman implanted in their uterus.

Blood tests can confirm the diagnosis, and other tests are done to identify the cause. Various measures, including estrogen (typically taken until about age 51, when menopause occurs on average), can relieve or reduce symptoms.

Premature menopause and early menopause, whether spontaneous or induced, are associated with long-term health risks which may include premature death, cardiovascular disease, neurologic disease, osteoporosis, psychosexual dysfunction, and mood disorders.

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Major Key Players of the Market:

Novo Nordisk A/S (Denmark), Pfizer Inc. (US), Allergan (Ireland), Eli Lily and Company (US), Emcure Pharmaceuticals Ltd (India), Novartis AG (Switzerland), Cipla Inc. (India), Teva Pharmaceuticals (Israel), Merck & Co., Inc. (US), Abbott Laboratories (US), and others.

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This study also covers company profiling, specifications and product picture, sales, market share and contact information of various regional, international and local vendors of Global Premature Menopause Market. The market opposition is frequently developing greater with the rise in scientific innovation and M&A activities in the industry. Additionally, many local and regional vendors are offering specific application products for varied end-users. The new merchant applicants in the market are finding it hard to compete with the international vendors based on reliability, quality and modernism in technology.

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Premature Menopause Market 2021-28 healthcare leads to shooting revenues with Novo Nordisk A/S, Pfizer, Allergan, Eli Lily and Company, Emcure...

After treating over 35,000 men, we understand their needs and we know what works.

GREENVILLE, S.C. (PRWEB) December 29, 2020

Greenville Mens Clinic, a local mens health company, has announced today an exciting merger & rebranding campaign that will better reflect its mission and dedication to mens health. The announcement of the new brand comes with a new patient-centric website that is solely focused on mens health from a global perspective.

With COVID-19 pushing many companies to the brink of closure, MHP and GMC saw an opportunity to meet mens health needs at the local and national level. By joining with Mens Health Partners, Greenville Mens Clinic is able to transition from a local mens health presence to one that is able to serve clients nationwide.

Our vision is to become a national leader in mens health, said Shauli Greenspan, CEO of Mens Health Partners, treating patients is what we do best, and this merger and rebranding allows us to address our patients needs more globally. This is not just cosmetic; weve taken this opportunity to evolve our service line and our treatment pathways to better address our clients needs.

Mens Health Partners is changing the way mens health is done in Greenville, South Carolina. They offer affordable, custom treatments to resolve Erectile Dysfunction & Peyronies. MHP also provides weight loss, solutions for hormone deficiencies, and provides STD testing.

We have always offered a discreet and confidential approach to our clients, said Ty Hopkins, COO of Mens Health Partners, after treating over 35,000 men, we understand their needs and we know what works. A vast majority of our clients have tried online pills to remedy a pretty complex disease, these pills often fail with time. We have achieved a 95% success rate with our clients, and we want to close that gap even more.

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The Men's Health Partners and Greenville Men's Clinic Merger Changes the Way Men's Healthcare is done in South Carolina - PR Web

Before this year, I thought that you could be either pregnant or not pregnant. As it happens, its not always that simple. Last August, two weeks after an embryo was transferred to my uterus in the basement of a Harley Street fertility clinic, I held a pregnancy test up to the strong sunlight at my bedroom window. The control line, which indicated whether or not the test was working, was clear and dark pink. The test line, which indicated whether or not I was pregnant, was faint, like a shadow. In some light it was impossible to discern in some light but standing at the window, there it was: hope.

The embryo had been in a freezer for the best part of the year before it was transferred. It had been created using my egg and my husbands sperm at our local hospital in east London because, due to illness, conceiving naturally was no longer possible for us. We had commenced treatment after almost a year on an NHS waiting list: I injected myself with hormones and doctors retrieved eggs from my ovaries; they were injected with my husbands sperm and became embryos. Due to a complication, it wasnt safe for them to be transferred straight away so they were frozen. On New Years Eve 2019, we toasted our three frozen embryos as we looked ahead to 2020: this would be the year I became pregnant, this would be a good year.

In February 2020, the first of the frozen embryos was transferred. My husband was there with me, holding my hand, as the doctor placed it in my uterus. She reeled off instructions afterwards: no sex for seven days, no alcohol, no smoking, do an at-home pregnancy test in 13 days.

The test was negative; the transfer had failed. And in those 13 days, the world had changed. It was clear that coronavirus had spread to Europe. Soon, Downing Street announced that the virus was likely to spread in the UK in a significant way. The fertility clinic we were being treated at closed shortly afterwards; staff were deployed to other parts of the hospital as the NHS buckled under the strain of the pandemic. At the end of March, all fertility treatment in NHS and private clinics was cancelled. IVF became just another part of life that would not happen now: no parties, no theatre, no babies that feel like miracles, no leaving the country, no hugs.

To live with infertility and to undergo fertility treatment is to live with constant uncertainty. Often, it is unclear why pregnancy doesnt occur in the first place: unexplained infertility is a common diagnosis. As a patient, you offer yourself up in the quest for certainty. You are probed, an ultrasound wand inserted into your body, manoeuvred inside you, as a sonographer counts the little sacs in your ovaries. Blood is drawn and hormone levels are measured. Still, no one can say what you want to hear, no one can say that you will definitely have a baby.

By the summer, fertility clinics were authorised to resume treatment but our clinic remained shut: I dont know when it will reopen, a receptionist told me when I called the hospital switchboard. My husband and I arranged to have both the remaining embryos transferred to a private clinic, at a cost of thousands. I imagined myself with twins, what a handful they would be. On the day of the transfer, the embryologist told me that one of the frozen embryos hadnt survived the thaw.

Isnt that rare? I asked.

Its uncommon but not rare, he said. It happens.

The last embryo of the three transferred in clinic basement as my husband waited on the street because Covid regulations meant he couldnt come inside was the one that created that shadow line on a pregnancy test back in August. It nearly made it. It was a sort-of pregnancy; an almost pregnancy; what is known, officially, as a chemical pregnancy or early miscarriage. By then we knew 2019s three embryos werent going to become our future children.

We moved to Ireland, where I am from, and started a new cycle, at a new clinic. All was going well with the process until it wasnt. There will be so many eggs, I was told by a doctor on a Monday. Then, on a Wednesday, I was told that, actually, there will be very few eggs.

It is now the end of the year and the uncertainty is ongoing. I live alongside the unknowing. And after so much uncertainty, I find that I can just about tolerate it. I got good practice this year, we all did this was the year that certainty evaporated, the word plan became more or less meaningless. And without the sturdy reliability of a plan, I had to turn to gratitude instead. Before this year, I thought it was cheesy to be thankful for things that are common or easily won, but when you witness the unravelling of the way life has always been, when you look on as industries and livelihoods are destroyed, when you know families who have been bereaved suddenly, that changes how you see things. Amid so much loss, it becomes clear that you are lucky and it becomes easier to feel grateful.

I still feel anger, despair and, sometimes when I see somebody elses huge bump, a terrible envy. I still use Google to search for answers to weirdly specific queries, hoping that somebody, somewhere, on some fertility forum, will tell me that it will all work out. I still long for certainty but, in the absence of it, I get by on hope and gratitude.

When the weather forecast predicts rain, but they were wrong and it stays dry, that is something to be grateful about. When the heron might not be there, but then he is, standing proud by the riverbank as you walk home from the IVF clinic, that is something to be grateful about. When it doesnt work this time, but there is always next time, that is something to be grateful about.

Lynn Enright is a journalist and the author of Vagina: A Re-education

Read the original post:
My fertility treatment failed three times in 2020 and I discovered how to live with uncertainty - The Guardian

Breakfast may be the "most important meal of the day," but lunch is certainly a huge deal as well. A good, healthy lunch can help keep your energy levels high and prevent you from mindless mid-afternoon snacking later. But what would be considered the healthiest lunches to have? We reached out to a few registered dietitians and asked them their recommendations for the healthiest lunches you can possibly have.

Here are the meals they say are the best-of-the-best, and for more healthy tips, be sure to check out our list of the 100 Easiest Recipes You Can Make.

"One of the healthiest lunches you can have is grilled salmon over a colorful salad," says Lisa Young, PhD, RDN, and author of Finally Full, Finally Slim. "Salmon is high in protein which helps you to feel full and rich in heart-healthy omega 3 fatty acids (known as "good fats"). A colorful salad contains an assortment of veggies, which are high in antioxidants, vitamins, and minerals and the different colors ensure that you are getting a mix of different nutrients. I love a blend of romaine lettuce, spinach, carrots, tomatoes, red peppers, and cucumbers."

Or try ourHoney-Mustard Glazed Salmon With Roasted Asparagus Recipe.

"Did you know that seafood is one of the best dietary sources of animal protein? It's packed with vital nutrients, such as heart-healthy omega-3s, and has less saturated fat and cholesterol than other protein options," says Rima Kleiner MS, RD, a Registered and Licensed Dietitian and Nutritionist at Dish on Fish. "Protein may help our brains recognize the hormone leptin, which helps us feel fuller longer and provides energy for our bodies."

An easy way to get seafood into your lunch routine is prepping a tuna melt! This healthy tuna and veggie melt is a filling lunch that's still low in calories but packed with nutrients.

"I love putting veggies and grain bowl together because you can use up what you've got in the fridge and create endless variations," says Frances Largeman-Roth, RDN. "I like starting with a base of high fiber barley or quinoa and adding whatever colorful veggies I have on hand. This time of year it's probably roasted Brussels sprouts and carrots, plus a bit of kimchee for probiotics and then a packet of tuna for high-quality protein. I like the ones from Bumble Bee because they come in tasty flavors like Thai Chili, they require no prep, and they offer important vitamins and minerals, like vitamin D (so important for winter!), iron, and selenium."

Here'sHow to Make a Delicious Buddha Bowl for Weight Loss.

"I am a huge fan of packing my lunch like you would your kid's for school," says Amy Goodson, MS, RD, CSSD, LD, and author of The Sports Nutrition Playbook. "One of my go-to's is the 'Adult Lunchable' that includes cheese, whole grain crackers, grapes, turkey, veggie like mini sweet peppers, baby carrots or cherry tomatoes, and some nuts. With fiber, protein, and healthy fat, you will get full faster and stay full longer, plus get tons of nutrients!"

"So many people get protein and veggies on their salad, but then find themselves sluggish mid-afternoon because they did not get carbohydrates at lunch," says Goodson. "The ultimate salad is one with all the food groups. As a dietitian, one of my favorites is a pan-seared salmon salad with mixed greens, goat cheese, berries, pecans, and a grain like quinoa or farro. The best part of the 5-Food Group salad lunch is that you can mix and match your proteins, cheese, nuts, fruit, and grains to make all kinds of combinations to keep it interesting and flavorful. Including all five food groups will help you feel more satisfied and less likely to go grazing on snack foods a few hours later."

Or try our Warm-Kale Quinoa Salad, which includes all of the food groups Goodson recommends!

"Soup and salad lunches offer an opportunity to get lots of healthy foods such as veggies, beans, lentils, nuts, and seeds," says MyNetDiary's Registered Dietitian and MS, Brenda Braslow. "These plant-based meals offer loads of protein, vitamins, minerals, antioxidants, and fiber to keep our bodies healthy and immune systems strong."

Try our Veggie-Packed Minestrone Pesto Soup with a simple green salad for lunch!

"A quick and easy lunch I rely on quite a bit is what I call [the] Egg Scramble Whole Wheat Tortilla Wrap," says Cheryl Mussatto MS, RD, LD of Eat Well To Be Well RD. "Scramble two eggs with black beans along with diced cherry tomatoes and diced avocado. When cooked, place in the whole wheat wrap with a sprinkle of pepper jack cheese topped with fresh salsa and you're done. Protein-packed, fiber-filled, rich in monounsaturated fat, and simply delicious, this keeps me satiated for hours until dinner. I'll also include a side of fruit such as a few apple slices, grapes, or a small pear for a more well-balanced meal and for extra fiber."

Try our version with this Fiber-Filled Breakfast Burrito recipe!

"Lunch is an important meal of the day. You want to go for, not only what keeps you full, but also what gives you the energy to go about the next five or so hours of school, work, or any other day's activity," says Edie Reads, RD and chief editor at healthadvise.org. "You also want to avoid [processed] carbs. These are unhealthy, will easily lead to weight gain and digestive issues such as constipation, diarrhea, and bloating."

Reads says salads, in particular, are a great choice for lunch.

"Make yours with lots of proteins, and greens," says Reads. "If you want, you can top it up with some dressing. Try out the Mediterranean-style salad."

This Greek Salad Recipe is a great place to start!

"Some vegetable curry will also do," says Reads. "it comes packed with lots of vitamins and antioxidants. You'll also feel full for longer and may not need to snack."

Try our version with this Cauliflower and Butternut Squash Curry Stir Fry!

Rachel Paul, PhD, RD, CDN, recommends making a stuffed avocado salad for an easy, filling, low-carb lunch idea.

"[To make], slice an avocado in half and take out the pit," says Paul. "Mix a can of tuna with 1/4 cup diced grape tomatoes. Add the tuna to the avocado halves and sprinkle with everything but the bagel seasoning. Have 1 to 2 cups of baby carrots on the side. This meal is full of protein, fat, and high fiber veggies, making it very fillingit will keep you full for hours."

Or try our version with this Light Avocado Crab Salad!

Breakfast sandwiches make for great lunch sandwiches, too!

"It consists of carbohydrates, protein, and sodium that are healthy and also can help in weight loss," says Shannon Henry, RD for EZCare Clinic.

To make this particular sandwich, cook up two eggs. Spread a little bit of butter on your bread and add a slice of Swiss cheese, fried egg, avocado, cheddar cheese, and the remaining bread slice. Grill on the stove for a few minutes on each side until golden brown!

For more lunch ideas, try one of these 73+ Best Healthy Lunch Recipes.

Read more from the original source:
The 11 Healthiest Lunches to Have, According to Dietitians | Eat This Not That - Eat This, Not That

Here's a little history lesson: Pepsi, Coca Cola, and Dr. Pepperthe oldest sodas in the worldwere all invented by pharmacists. In fact, these soft drinks were originally intended to serve as remedies for nausea, headaches, heartburn, and other ailments. Considering the fact that the most common ingredients found in soda these days include high fructose corn syrup, artificial flavorings, and food colorings, and phosphoric acidall of which can have negative health effects when consumed in excessthat's pretty surprising. While the occasional can of soda may not have dangerous implications, doctors say drinking it even semi-regularly is one of the dangerous soda habits you can get into from a health standpoint.

"There's a risk to develop oral cavity problems, kidney malfunction, decreased blood flow to the brain, heart disease, osteoporosis, and ulcers, among many other diseases that can be exacerbated by a soda addiction," says Dr. Ava Williams, a board-certified Primary Care doctor at Doctor Spring. "You may not know it, but each can you drink already brings you a step closer to any of those illnesses."

One of the reasons why soda is considered so unhealthy is that it contains virtually no nutrientsmeaning it's basically just empty calories. Not to mention, the typical can of soda contains about 7 to 10 teaspoons of sugar. According to Harvard Health, if you were to drink just one serving of soda a day and not cut back on calories in other areas of your diet, you could gain 5 pounds a year. In part, this is because your liver turns fructose (sugar) into fat when you consume too much of it.

But beyond potentially gaining weight, research has repeatedly proven that these syrupy sweet beverages can also increase your risk of many chronic diseases, including type 2 diabetes, metabolic syndrome, and gout. One study even found that a higher soft drink intake was associated with an increased risk of death from any causeregardless of whether it contained sugar or artificial sweetener.

In case you need a little more motivation to nix soft drinks from your diet once and for all, here are how some of the most dangerous soda habits could impact your health. And for more healthy tips, be sure to check out our list of 15 Underrated Weight Loss Tips That Actually Work.

You may want to think twice before guzzling down a soda on the daily.

"The high amount of sugars (fructose) that are present in sodas can make you gain weight without fulfilling your hunger," says Dr. Amber O'Brien, MD, a health expert for Mango Clinic.

The average can of soda contains It's not just the excess sugar and calories in soda itself that poses an issue when it comes to weight gain. There have been dozens of studies that have explored the link between soft drink consumption and weight, and the consistent finding is that the more soda you drink, the more likely you are to consume more calories from other sources as well.

"It can also lead to vitamin or mineral deficiencies, as you are no longer hungry after drinking these empty calories," says Dr. Leann Poston MD, a licensed physician with Invigor Medical.

That's not all. Dr. Poston and Dr. O'Brien both note that sugary beverages like soda can also cause insulin resistance.

"Insulin is a hormone that ushers sugar into body cells," explains Dr. Poston. "If cells are resistant to the effects of insulin, glucose (sugar) increases in the blood and leads to Type 2 diabetes. Weight gain from soda consumption can also lead to insulin resistance, which can ultimately lead to type 2 diabetes."

Here are the 28 Unhealthiest Sodas That Are Never Worth Drinking.

Soda contains certain acidsincluding phosphoric acid and carbonic acidwhich can make your teeth more vulnerable to decay.

"If your tooth enamel is weak, you should avoid consuming sodas as they can cause cavities and tooth enamel destruction," says Dr. O'Brien.

Dr. Poston adds that the sugar in soda can lead to a plaque buildup on your teeth by feeding the bacteria in your mouth.

"Soda is highly acidic and therefore can increase the risk of cavities and gum disease," she says.

Basically, regularly drinking soda could ultimately lead to more dentist office visits.

Dr. Williams also points out that the phosphoric acid content can raise your risk of developing osteoporosis because when it gets digested in your stomach, it binds to calcium and therefore prevents your body from absorbing it for bone strength.

Here are 12 Foods and Drinks to Avoid If You Have Sensitive Teeth.

When those afternoon hungerpangs hit at the office, experts say one of the worst things you can do is grab a soda from the vending machine. In fact, while the bubbles may make you feel a temporary sense of fullness, soda could also cause an upset stomach if you haven't eaten anything recently.

"It's most dangerous to drink soda on an empty stomach because when your stomach receives something for digestion, it releases acid," says Dr. Williams. "When you drink soda, an acidic drink, you're just releasing extra acid into your stomach. It disrupts the acid-alkaline balance in your stomach and linings of your gastrointestinal system, causing you to feel tummy aches and pains."

Instead, sip on one of these 12 Healthiest Teas on Grocery Store Shelves.

Think diet soda is healthier for you? Think again. Just because these alternatives are calorie- and sugar-free doesn't mean they don't come with their own risks.

"Diet sodas contain more chemicals than regular sodas," says Dr. Poston. "These chemicals can adversely affect gut bacteria and insulin sensitivity. There are even some scientific studies that show that artificial sweeteners can cause insulin resistance and weight gain, just like sugar, but the jury is still out on this."

Not only that, but Dr. Williams adds that diet soda is just as addicting as regular soda, and contains nearly all of the same questionable ingredients with the exception of the type of sweetenermeaning it comes with many of the same negative health implications. In fact, research has found that consuming high amounts of diet soda and artificial sweeteners is associated with an increased risk of obesityand metabolic syndrome. Additionally, studies have linked diet soda to an increase in the risk of stroke, kidney disease, osteoporosis, tooth decay, high blood pressure, type 2 diabetes, and even depression.

It's no secret that consuming caffeine can make it more difficult for you to fall asleep. Once it enters the bloodstream, it causes your body to ramp up adrenaline production while increasing your blood pressure and simultaneously blocking the chemicals in your brain that allow you to feel sleepy. That's why Dr. Williams strongly advises against drinking sodas that contain caffeine late in the day.

Even in moderate doses, it can cause insomnia, headaches, nervousness, anxiety, irritability, sleep disturbances, rapid heartbeat, and excessive urination.

It's also worth mentioning that caffeine can have diuretic propertiesby causing you to urinate more frequently, it may put you at a higher risk for dehydration.

Insufficient sleep is associated with a whole slew of health concerns, and since drinking soda at night or even in the late afternoon can inhibit your ability to sleep at night, that's one habit that's best to ditch.

Ready to give up soda for good? Here are 6 Surprising Reasons to Finally Give Up Soda.

Excerpt from:
The Most Dangerous Soda Habits You Need to Kick, Say Doctors - Eat This, Not That

Blurred vision

Blurred vision is one of the earliest warning signs of diabetes, warned Specsavers clinical spokesman, Dr Nigel Best.

Those most at risk are people whose vision swaps between blurry and perfectly normal.

Its caused by blood sugar levels being unstable, Best exclusively toldExpress.co.uk.

Fluctuating blurred vision is the main symptom people with diabetes get in their eyes, he said.

People may find that one day they have blurred vision but another day they can see perfectly fine, this is down to their sugar levels not being stable.

Blurred vision is also a warning sign of diabetic retinopathy, a complication caused by damage to the blood vessels at the back of the eye.

Diabetes patients are more at risk of developing blurred vision and changes to the eyes, according to Ophthalmic Consultants of London's retinal surgeon, Mr Shahram Kashani.

When the condition is advanced, it can cause abnormal blood vessels to develop at the back of the eye.

These can lead to a number of complications, including floaters.

Floaters are dark spots in your vision that may appear as black or grey specks or strings.

See more here:
Type 2 diabetes: Blurred vision and floaters in the eyes are signs of high blood sugar - Express

I've been dealing with acne for so long that oftentimes, I forget what my clear, baby-faced skin once looked like back in middle school. If you, too, have been dealing with acne for most of your adult life (according to the American Academy of Dermatology, acne occurring in adults is steadily increasing), you've probably tried every over-the-counter (OTC) and prescription treatment available in an attempt to keep your breakouts at bay.

As you probably already know, benzoyl peroxide and salicylic acid are the two most widely used ingredients within the dermatology field, and have been proven to kill acne-forming bacteria underneath the skin. The vast majority of skin-care products feature these two powerhouses within their acne-focused formulas, and while they do work for some folks, they arent the cure-all for everyone.

No, the list of ingredients below are not all necessarily new to the dermatology world, but they are all new developments in recent acne-fighting formulas many scientists and dermatologists are just now discovering the potential efficacy that these ingredients can have in treating and minimizing breakouts, without the added irritation that comes along with ingredients like salicylic acid and benzoyl peroxide. If these powerhouse ingredients aren't working for you, it might be time to try something new.

Whether it's adding probiotics, thyme and oregano, monk's pepper, honey, or clascoterone to your skin-care regimen, read on to discover the multiple alternatives research has suggested have the potential to also fight against acne, each in their own unique way.

The connection between your gut health and skin health only seems to be growing, and many probiotic-focused skin-care brands, including Aurelia Skincare and Ellis Day Skin Science, are developing products to create balance outside the gut microbiome, onto the skin microbiome.

"An imbalance of bacteria in the gut can lead to leaky gut, but an imbalance of bacteria on the skin can lead to something I call 'leaky skin,'" explains Whitney Bowe, a board-certified dermatologist in the greater New York City area and author of the book The Beauty of Dirty Skin. "When your skin microbiome is off-balance, meaning that the healthy balance of good bacteria on your skin is not intact, this can compromise your skin's natural barrier. This leads to inflammation, which, in turn, results in chronic skin conditions like acne, eczema, rosacea, and psoriasis."

An unhealthy skin microbiome can not only trigger chronic, ongoing inflammation in the skin, but it can also allow unhealthy, inflammatory microbes to take hold and thrive. "Specifically, in the case of acne, microbial balance on the skin is critical because it helps prevent inflammation, helps maintain a healthy skin barrier (which is so important in preventing acne), and it keeps inflammatory microbes like P. acnes from overgrowing and exacerbating papules and pustules in the skin," explains Bowe.

Read the original here:
7 New Acne-Treating Ingredients Alternative Acne Treatments - Allure Magazine

This week we experienced the shortest day of the year well if youre a cup half-empty type of person. Or, if you tend to be more positive (something I strive to be), it was the longest night of the year! Stating the obvious, that we are not seeing the sun as much, is clearly that, stating the obvious. It is no wonder people start feeling lethargic, moody and stuck in a rut.

Nothing says, lets get energized and have a productive day like heading in to work when it is pitch black outside, your car needs to be plugged in and you are buried in winter gear.

MORE FROM KRISTEN ASLESON:

For as many as one out of five people, winter means much more than having to deal with unruly hair and dry skin. Those people suffer from a disorder called Seasonal Affective Disorder, or SAD. According to the American Psychiatric Association, 75 percent of those people are women.

SAD is a type of depression that occurs every year at the same time. Most peoples symptoms begin in the early fall and continue throughout the winter months. And for most, once the sunnier days of spring and summer break through, the symptoms disappear.

SAD begins to appear in myriad of ways, including:

Depression.

Hopelessness.

Anxiety.

Heavy, leaden feeling in the arms or legs.

Social withdrawal.

Oversleeping.

Loss of interest in activities you once enjoyed.

Appetite changes, especially craving foods high in carbohydrates

Weight gain.

Difficulty concentrating.

I am sure reading this list of is causing a lot of readers to evaluate their feelings. Keep in mind it is normal to have some days when you are feeling more down than others. Even the happiest of people struggle to keep their attitudes on the perky side during the dreary days of winter. But, if you feel down for long stretches at a time, and the activities that normally you enjoy cant seem to get you motivated, then maybe it is time to see a doctor.

According to Mayo Clinic, the specific cause of SAD is unknown. However, as with many mental health conditions, genetics, age and your bodys chemical makeup all play a role in the development of this condition.

There are a few specific factors to attribute to the development of this condition. For instance, the reduced level of sunlight in fall and winter may disrupt your bodys internal clock, leading to feelings of depression.

Feelings of depression can also be caused by a drop in levels of serotonin. Serotonin is a brain chemical that affects ones mood, and it may have a role in seasonal affective disorder.

Lastly, the changes in the season can disrupt the balance of the natural hormone melatonin. This disruption in balance can interrupt sleep patterns and cause moodiness.

If you are having severe symptoms, you may need medications, light therapy or other treatments. However, here are some ideas that will help you battle those down in the dumps days better.

Make your environment sunnier and brighter by opening blinds, trimming tree branches that block sunlight or adding skylights to your home. Sit closer to bright windows while at work or home.

As cold as it is, get outside, even if only for a few seconds at a time. The best time to do this is within two hours of getting up.

Regular exercise! Getting physical helps relieve stress and anxiety. Being more fit can make you feel better about yourself, which also helps lift your mood.

If you suffer from SAD, you are not alone. There are thousands of people who experience the winter blues and blahs. If you are one who experiences more serious symptoms, seek help. The good news is that there are ways to cope and other plans that can help you get through the winter months.

Kristen Asleson is owner of Midwest Virtual Assistants. Send comments and ideas to news@postbulletin.com.

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Winter got you down? It could be Seasonal Affective Disorder - PostBulletin.com

The report titled Global Thyroid Stimulating Hormone Test Kit Market is one of the most comprehensive and important additions to QY Researchs archive of market research studies. It offers detailed research and analysis of key aspects of the global Thyroid Stimulating Hormone Test Kit market. The market analysts authoring this report have provided in-depth information on leading growth drivers, restraints, challenges, trends, and opportunities to offer a complete analysis of the global Thyroid Stimulating Hormone Test Kit market. Market participants can use the analysis on market dynamics to plan effective growth strategies and prepare for future challenges beforehand. Each trend of the global Thyroid Stimulating Hormone Test Kit market is carefully analyzed and researched about by the market analysts.The market analysts and researchers have done extensive analysis of the global Thyroid Stimulating Hormone Test Kit market with the help of research methodologies such as PESTLE and Porters Five Forces analysis. They have provided accurate and reliable market data and useful recommendations with an aim to help the players gain an insight into the overall present and future market scenario. The Thyroid Stimulating Hormone Test Kit report comprises in-depth study of the potential segments including product type, application, and end user and their contribution to the overall market size.

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In addition, market revenues based on region and country are provided in the Thyroid Stimulating Hormone Test Kit report. The authors of the report have also shed light on the common business tactics adopted by players. The leading players of the global Thyroid Stimulating Hormone Test Kit market and their complete profiles are included in the report. Besides that, investment opportunities, recommendations, and trends that are trending at present in the global Thyroid Stimulating Hormone Test Kit market are mapped by the report. With the help of this report, the key players of the global Thyroid Stimulating Hormone Test Kit market will be able to make sound decisions and plan their strategies accordingly to stay ahead of the curve.

Competitive landscape is a critical aspect every key player needs to be familiar with. The report throws light on the competitive scenario of the global Thyroid Stimulating Hormone Test Kit market to know the competition at both the domestic and global levels. Market experts have also offered the outline of every leading player of the global Thyroid Stimulating Hormone Test Kit market, considering the key aspects such as areas of operation, production, and product portfolio. Additionally, companies in the report are studied based on the key factors such as company size, market share, market growth, revenue, production volume, and profits.

Key Players Mentioned: Innodx, Bioscience, Daan, Ying Sheng Biology, Easydiagnosis, Tellgen, Bioscience, BGI, Chivd

Market Segmentation by Product: Time-resolved ImmunofluorescenceChemiluminescence Immunoassay

Market Segmentation by Application: HospitalClinic

The Thyroid Stimulating Hormone Test Kit Market report has been segregated based on distinct categories, such as product type, application, end user, and region. Each and every segment is evaluated on the basis of CAGR, share, and growth potential. In the regional analysis, the report highlights the prospective region, which is estimated to generate opportunities in the global Thyroid Stimulating Hormone Test Kit market in the forthcoming years. This segmental analysis will surely turn out to be a useful tool for the readers, stakeholders, and market participants to get a complete picture of the global Thyroid Stimulating Hormone Test Kit market and its potential to grow in the years to come.

Key questions answered in the report:

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Table of Contents:

1 Thyroid Stimulating Hormone Test Kit Market Overview1.1 Thyroid Stimulating Hormone Test Kit Product Overview1.2 Thyroid Stimulating Hormone Test Kit Market Segment by Type1.2.1 Time-resolved Immunofluorescence1.2.2 Chemiluminescence Immunoassay1.3 Global Thyroid Stimulating Hormone Test Kit Market Size by Type (2015-2026)1.3.1 Global Thyroid Stimulating Hormone Test Kit Market Size Overview by Type (2015-2026)1.3.2 Global Thyroid Stimulating Hormone Test Kit Historic Market Size Review by Type (2015-2020)1.3.2.1 Global Thyroid Stimulating Hormone Test Kit Sales Market Share Breakdown by Type (2015-2020)1.3.2.2 Global Thyroid Stimulating Hormone Test Kit Revenue Market Share Breakdown by Type (2015-2020)1.3.2.3 Global Thyroid Stimulating Hormone Test Kit Average Selling Price (ASP) by Type (2015-2020)1.3.3 Global Thyroid Stimulating Hormone Test Kit Market Size Forecast by Type (2021-2026)1.3.3.1 Global Thyroid Stimulating Hormone Test Kit Sales Market Share Breakdown by Type (2021-2026)1.3.3.2 Global Thyroid Stimulating Hormone Test Kit Revenue Market Share Breakdown by Type (2021-2026)1.3.3.3 Global Thyroid Stimulating Hormone Test Kit Average Selling Price (ASP) by Type (2021-2026)1.4 Key Regions Market Size Segment by Type (2015-2020)1.4.1 North America Thyroid Stimulating Hormone Test Kit Sales Breakdown by Type (2015-2020)1.4.2 Europe Thyroid Stimulating Hormone Test Kit Sales Breakdown by Type (2015-2020)1.4.3 Asia-Pacific Thyroid Stimulating Hormone Test Kit Sales Breakdown by Type (2015-2020)1.4.4 Latin America Thyroid Stimulating Hormone Test Kit Sales Breakdown by Type (2015-2020)1.4.5 Middle East and Africa Thyroid Stimulating Hormone Test Kit Sales Breakdown by Type (2015-2020)

2 Global Thyroid Stimulating Hormone Test Kit Market Competition by Company2.1 Global Top Players by Thyroid Stimulating Hormone Test Kit Sales (2015-2020)2.2 Global Top Players by Thyroid Stimulating Hormone Test Kit Revenue (2015-2020)2.3 Global Top Players Thyroid Stimulating Hormone Test Kit Average Selling Price (ASP) (2015-2020)2.4 Global Top Manufacturers Thyroid Stimulating Hormone Test Kit Manufacturing Base Distribution, Sales Area, Product Type2.5 Thyroid Stimulating Hormone Test Kit Market Competitive Situation and Trends2.5.1 Thyroid Stimulating Hormone Test Kit Market Concentration Rate (2015-2020)2.5.2 Global 5 and 10 Largest Manufacturers by Thyroid Stimulating Hormone Test Kit Sales and Revenue in 20192.6 Global Top Manufacturers by Company Type (Tier 1, Tier 2 and Tier 3) (based on the Revenue in Thyroid Stimulating Hormone Test Kit as of 2019)2.7 Date of Key Manufacturers Enter into Thyroid Stimulating Hormone Test Kit Market2.8 Key Manufacturers Thyroid Stimulating Hormone Test Kit Product Offered2.9 Mergers & Acquisitions, Expansion

3 Global Thyroid Stimulating Hormone Test Kit by Region (2015-2026)3.1 Global Thyroid Stimulating Hormone Test Kit Market Size and CAGR by Region: 2015 VS 2020 VS 20263.2 Global Thyroid Stimulating Hormone Test Kit Market Size Market Share by Region (2015-2020)3.2.1 Global Thyroid Stimulating Hormone Test Kit Sales Market Share by Region (2015-2020)3.2.2 Global Thyroid Stimulating Hormone Test Kit Revenue Market Share by Region (2015-2020)3.2.3 Global Thyroid Stimulating Hormone Test Kit Sales, Revenue, Price and Gross Margin (2015-2020)3.3 Global Thyroid Stimulating Hormone Test Kit Market Size Market Share by Region (2021-2026)3.3.1 Global Thyroid Stimulating Hormone Test Kit Sales Market Share by Region (2021-2026)3.3.2 Global Thyroid Stimulating Hormone Test Kit Revenue Market Share by Region (2021-2026)3.3.3 Global Thyroid Stimulating Hormone Test Kit Sales, Revenue, Price and Gross Margin (2021-2026)

4 Global Thyroid Stimulating Hormone Test Kit by Application4.1 Thyroid Stimulating Hormone Test Kit Segment by Application4.1.1 Hospital4.1.2 Clinic4.2 Global Thyroid Stimulating Hormone Test Kit Sales by Application: 2015 VS 2020 VS 20264.3 Global Thyroid Stimulating Hormone Test Kit Historic Sales by Application (2015-2020)4.4 Global Thyroid Stimulating Hormone Test Kit Forecasted Sales by Application (2021-2026)4.5 Key Regions Thyroid Stimulating Hormone Test Kit Market Size by Application4.5.1 North America Thyroid Stimulating Hormone Test Kit by Application4.5.2 Europe Thyroid Stimulating Hormone Test Kit by Application4.5.3 Asia-Pacific Thyroid Stimulating Hormone Test Kit by Application4.5.4 Latin America Thyroid Stimulating Hormone Test Kit by Application4.5.5 Middle East and Africa Thyroid Stimulating Hormone Test Kit by Application5 North America Thyroid Stimulating Hormone Test Kit Market Size by Country (2015-2026)5.1 North America Market Size Market Share by Country (2015-2020)5.1.1 North America Thyroid Stimulating Hormone Test Kit Sales Market Share by Country (2015-2020)5.1.2 North America Thyroid Stimulating Hormone Test Kit Revenue Market Share by Country (2015-2020)5.2 North America Market Size Market Share by Country (2021-2026)5.2.1 North America Thyroid Stimulating Hormone Test Kit Sales Market Share by Country (2021-2026)5.2.2 North America Thyroid Stimulating Hormone Test Kit Revenue Market Share by Country (2021-2026)6 Europe Thyroid Stimulating Hormone Test Kit Market Size by Country (2015-2026)6.1 Europe Market Size Market Share by Country (2015-2020)6.1.1 Europe Thyroid Stimulating Hormone Test Kit Sales Market Share by Country (2015-2020)6.1.2 Europe Thyroid Stimulating Hormone Test Kit Revenue Market Share by Country (2015-2020)6.2 Europe Market Size Market Share by Country (2021-2026)6.2.1 Europe Thyroid Stimulating Hormone Test Kit Sales Market Share by Country (2021-2026)6.2.2 Europe Thyroid Stimulating Hormone Test Kit Revenue Market Share by Country (2021-2026)7 Asia-Pacific Thyroid Stimulating Hormone Test Kit Market Size by Region (2015-2026)7.1 Asia-Pacific Market Size Market Share by Region (2015-2020)7.1.1 Asia-Pacific Thyroid Stimulating Hormone Test Kit Sales Market Share by Region (2015-2020)7.1.2 Asia-Pacific Thyroid Stimulating Hormone Test Kit Revenue Market Share by Region (2015-2020)7.2 Asia-Pacific Market Size Market Share by Region (2021-2026)7.2.1 Asia-Pacific Thyroid Stimulating Hormone Test Kit Sales Market Share by Region (2021-2026)7.2.2 Asia-Pacific Thyroid Stimulating Hormone Test Kit Revenue Market Share by Region (2021-2026)8 Latin America Thyroid Stimulating Hormone Test Kit Market Size by Country (2015-2026)8.1 Latin America Market Size Market Share by Country (2015-2020)8.1.1 Latin America Thyroid Stimulating Hormone Test Kit Sales Market Share by Country (2015-2020)8.1.2 Latin America Thyroid Stimulating Hormone Test Kit Revenue Market Share by Country (2015-2020)8.2 Latin America Market Size Market Share by Country (2021-2026)8.2.1 Latin America Thyroid Stimulating Hormone Test Kit Sales Market Share by Country (2021-2026)8.2.2 Latin America Thyroid Stimulating Hormone Test Kit Revenue Market Share by Country (2021-2026)9 Middle East and Africa Thyroid Stimulating Hormone Test Kit Market Size by Country (2015-2026)9.1 Middle East and Africa Market Size Market Share by Country (2015-2020)9.1.1 Middle East and Africa Thyroid Stimulating Hormone Test Kit Sales Market Share by Country (2015-2020)9.1.2 Middle East and Africa Thyroid Stimulating Hormone Test Kit Revenue Market Share by Country (2015-2020)9.2 Middle East and Africa Market Size Market Share by Country (2021-2026)9.2.1 Middle East and Africa Thyroid Stimulating Hormone Test Kit Sales Market Share by Country (2021-2026)9.2.2 Middle East and Africa Thyroid Stimulating Hormone Test Kit Revenue Market Share by Country (2021-2026)

10 Company Profiles and Key Figures in Thyroid Stimulating Hormone Test Kit Business10.1 Innodx10.1.1 Innodx Corporation Information10.1.2 Innodx Description, Business Overview10.1.3 Innodx Thyroid Stimulating Hormone Test Kit Sales, Revenue and Gross Margin (2015-2020)10.1.4 Innodx Thyroid Stimulating Hormone Test Kit Products Offered10.1.5 Innodx Recent Developments10.2 Bioscience10.2.1 Bioscience Corporation Information10.2.2 Bioscience Description, Business Overview10.2.3 Bioscience Thyroid Stimulating Hormone Test Kit Sales, Revenue and Gross Margin (2015-2020)10.2.4 Innodx Thyroid Stimulating Hormone Test Kit Products Offered10.2.5 Bioscience Recent Developments10.3 Daan10.3.1 Daan Corporation Information10.3.2 Daan Description, Business Overview10.3.3 Daan Thyroid Stimulating Hormone Test Kit Sales, Revenue and Gross Margin (2015-2020)10.3.4 Daan Thyroid Stimulating Hormone Test Kit Products Offered10.3.5 Daan Recent Developments10.4 Ying Sheng Biology10.4.1 Ying Sheng Biology Corporation Information10.4.2 Ying Sheng Biology Description, Business Overview10.4.3 Ying Sheng Biology Thyroid Stimulating Hormone Test Kit Sales, Revenue and Gross Margin (2015-2020)10.4.4 Ying Sheng Biology Thyroid Stimulating Hormone Test Kit Products Offered10.4.5 Ying Sheng Biology Recent Developments10.5 Easydiagnosis10.5.1 Easydiagnosis Corporation Information10.5.2 Easydiagnosis Description, Business Overview10.5.3 Easydiagnosis Thyroid Stimulating Hormone Test Kit Sales, Revenue and Gross Margin (2015-2020)10.5.4 Easydiagnosis Thyroid Stimulating Hormone Test Kit Products Offered10.5.5 Easydiagnosis Recent Developments10.6 Tellgen10.6.1 Tellgen Corporation Information10.6.2 Tellgen Description, Business Overview10.6.3 Tellgen Thyroid Stimulating Hormone Test Kit Sales, Revenue and Gross Margin (2015-2020)10.6.4 Tellgen Thyroid Stimulating Hormone Test Kit Products Offered10.6.5 Tellgen Recent Developments10.7 Bioscience10.7.1 Bioscience Corporation Information10.7.2 Bioscience Description, Business Overview10.7.3 Bioscience Thyroid Stimulating Hormone Test Kit Sales, Revenue and Gross Margin (2015-2020)10.7.4 Bioscience Thyroid Stimulating Hormone Test Kit Products Offered10.7.5 Bioscience Recent Developments10.8 BGI10.8.1 BGI Corporation Information10.8.2 BGI Description, Business Overview10.8.3 BGI Thyroid Stimulating Hormone Test Kit Sales, Revenue and Gross Margin (2015-2020)10.8.4 BGI Thyroid Stimulating Hormone Test Kit Products Offered10.8.5 BGI Recent Developments10.9 Chivd10.9.1 Chivd Corporation Information10.9.2 Chivd Description, Business Overview10.9.3 Chivd Thyroid Stimulating Hormone Test Kit Sales, Revenue and Gross Margin (2015-2020)10.9.4 Chivd Thyroid Stimulating Hormone Test Kit Products Offered10.9.5 Chivd Recent Developments

11 Thyroid Stimulating Hormone Test Kit Upstream, Opportunities, Challenges, Risks and Influences Factors Analysis11.1 Thyroid Stimulating Hormone Test Kit Key Raw Materials11.1.1 Key Raw Materials11.1.2 Key Raw Materials Price11.1.3 Raw Materials Key Suppliers11.2 Manufacturing Cost Structure11.2.1 Raw Materials11.2.2 Labor Cost11.2.3 Manufacturing Expenses11.3 Thyroid Stimulating Hormone Test Kit Industrial Chain Analysis11.4 Market Opportunities, Challenges, Risks and Influences Factors Analysis11.4.1 Thyroid Stimulating Hormone Test Kit Industry Trends11.4.2 Thyroid Stimulating Hormone Test Kit Market Drivers11.4.3 Thyroid Stimulating Hormone Test Kit Market Challenges11.4.4 Porters Five Forces Analysis

12 Market Strategy Analysis, Distributors12.1 Sales Channel12.2 Distributors12.3 Downstream Customers

13 Research Findings and Conclusion

14 Appendix14.1 Methodology/Research Approach14.1.1 Research Programs/Design14.1.2 Market Size Estimation14.1.3 Market Breakdown and Data Triangulation14.2 Data Source14.2.1 Secondary Sources14.2.2 Primary Sources14.3 Author Details14.4 Disclaimer

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Thyroid Stimulating Hormone Test Kit Market In-Depth Analysis Of Competitive Landscape, Executive Summary, Development Factors 2026 | Innodx,...

Tremendous progress has been made to understand the strategies that can be used to overcome ESR1 mutations in estrogen receptor (ER)positive breast cancer, said Debu Tripathy, MD, who added that potent selective ER modulators (SERMs) may be the key to combat these mutations.

Selective [ER] modulators can probably, to some extent, be effective [against] ESR1-mutant cells, said Tripathy. The effect to which they can reverse resistance probably depends on many aspects of the agent. These need to be formally studied not just in the lab, but in clinical trials. We are starting to get some hints of that [work], but its just the beginning.

ESR1 mutations generally arise following treatment with an aromatase inhibitor (AI), explained Tripathy, so acquiring genomic information after a patient progresses is critical to inform treatment selection.

The novel SERM lasofoxifene is currently being investigated in combination with the CDK4/6 inhibitor abemaciclib (Verzenio) in the phase 2 ELAINEII trial (NCT04432454) in patients with advanced or metastatic ER-positive, HER2-negative breast cancer whose tumors harbor an ESR1 mutation. Moreover, in May 2019, the FDA granted a fast track designation to lasofoxifene for the treatment of female patients with ER-positive, HER2-negative metastatic, ESR1-mutant breast cancer.

In an interview with OncLive, Tripathy, professor of medicine and chair of the Department of Breast Medical Oncology at The University of Texas MD Anderson Cancer Center, discussed the role of CDK4/6 inhibitors in ER-positive, HER2-negative breast cancer, the emergence of SERMs, and the growing understanding of ESR1 mutations in this space.

Tripathy: When patients progress on a CDK4/6 inhibitor, I will generally discontinue the use of CDK4/6 inhibitors. No clear data [show] that patients who become resistant [to a CDK4/6 inhibitor] may be sensitive to other [CDK4/6] inhibitors; however, some anecdotal datafrom individual hospital series suggest there could be some non-overlapping sensitivity.

However, we have many other options, which is why I will generally move on to another form of therapy. We need to formally study the impact of 1 CDK4/6 inhibitor after progression on another because we may find that some of these agents perform better in that setting.

I tend to get genomics at the very beginning when patients are newly diagnosed, although I may not use that information in the first-line setting. However, it is good to have [the genomic information], especially for truncal mutations. [Truncal mutations] tend to be prevalent in most of the cells, such asPIK3CAmutations.ESR1mutations tend to be subclonal and may not be present [up front] but may arise later after the patient has been on an [AI].

If I havent gotten [genomic information] at the beginning, I will certainly get it at the time of progression on first-line therapy.

ESR1 mutations tend to arise in the presence of pretreatment, particularly with estrogen-deprivation therapy, which pharmacologically, would be AIs. The Cancer Genome Atlas published that ESR1 mutation rates were very low, at perhaps 1% or so at diagnosis and based on the patients primary tumor. However, [ESR1mutations] really [arise] after exposure to AIs.

That makes sense because AIs work by depriving estrogen from the environment. To be activated, ERs need to bind to estrogen. So, [AIs] select for any mutations that may occur where a mutation [is present] in the ER that allows it to be activated without the presence of estrogen; that is what most activating ESR1mutations do. Specifically, upon exposure to AIs, is when we start to see these mutations arise.

The PADA-1 trial showed that ESR1 mutations can be acquired and they can be subclonal, meaning that you can see a very low fraction of all the tumor DNA that has that mutation. However, you cant underestimate that power of a small fraction of activated ESR1-mutant cells. We do see that pattern of resistance. [Additionally, the trial showed] that patients can have multiple clones.

How do you combat ESR1 mutations? One way is to totally take them out of the equation and to target them for downregulation or proteasomal degradation, which is what selective ER downregulators like fulvestrant [Faslodex] do. However, they dont do it completely; these drugs dont completely circumvent resistance. Another way is to use [SERMs] that may not necessarily inactivate the ER, but instead, modulate the ER in the way it behaves, the conformation of it, and how it binds to co-activators, co-receptors, and co-repressors. [Doing this], ultimately, mediates the expression of genes that guide what estrogen does, which is generally a growth signal.

Lasofoxifene does have the ability to downregulate the transactivating nature of the ER, including ESR1mutations. In the lab, we can study how well an ER is able to activate the genes it targets. ERs are known to target numerous genes of interest that lead to cell growth. We can measure to what extent a drug will interact with ESR1 so that it negatively regulates it. In other words, the genes that are normally transcribed by estrogen are not transcribed. More importantly, growth is arrested. That has been demonstratedin vitroandin vivousing ESR1-mutant models.

Those data are compelling. They show that we can get growth inhibition in ESR1mutations and that it can be potentially aided with CDK4/6 inhibitors. Although I dont have the exact data at hand, I have seen examples of this and other data that show [tumor growth] can be reversed in cell-line models.

What we see in those cell-line modelseven in animal models, which are more accurate but may not be the whole storymay not turn out to be the case in the tumor microenvironment and all of the other factors involved. Therefore, although this is very supportive and raises enthusiasm for getting these types of drugs into clinical trials, we need to wait to see what happens when patients are taking these drugs.

The ELAINE trial is comparing fulvestrant with lasofoxifene in patients with ESR1 mutations. Its a direct test of the hypothesis that [lasofoxifene] may be more favorable than [fulvestrant], which we now consider a reasonable drug to use when we see ESR1 mutations or in the second line in general.

ELAINEII is designed to move [lasofoxifene] further, combining it with a CDK4/6 inhibitor. It will allow patients who have seen prior CDK4/6 inhibitors [to enroll].There is some anecdotal evidence that responses have been seen with abemaciclib after progression on other CDK4/6 inhibitors.

The approval of abemaciclib was based on a trial that showed responses in refractory hormone receptorpositive disease as a single agent, but those patients had not been previously exposed to CDK4/6 inhibitors. We believe that the combination of these 2 different strategies could bring about more responses and longer time to progression.

One of the issues is pairing CDK4/6 inhibitors with different endocrine therapies; we havent formally compared that. We do know from the FALCON trial that, when using endocrine therapies alone, fulvestrant is slightly better than AI therapy, particularly in patients who havent been treated before or have non-visceral disease. Then, the MONALEESA-3 study was a trial that took advantage of the FALCON findings and compared treatment with fulvestrant alone versus fulvestrant plus ribociclib [Kisqali] regardless of first- or second-line therapy. That study showed a significant improvement in outcomes with a hazard ratio of around 0.5, which has been seen before.

The PARSIFAL trial, on the other hand, was a direct comparison with palbociclib. Patients received an AI or fulvestrant. The trial did not show a difference in progression-free survival.We are left without knowing what population fulvestrant might be best for, but certainly fulvestrant is a reasonable option in the first- or second-line setting. We have less data regarding what to do in the second line for patients who received fulvestrant up front, but the PARSIFAL and MONALEESA-3 studies showed that [ribociclib and palbociclib] are both reasonable agents to use and could be building blocks for [combinations] with other targeted agents.

The sub-classification of the breast cancer subtypes is very important in general. In breast cancer, not all patients with luminal A or luminal B [disease] are the same. There may be certain aspects about the different pathways involved in growth and other cellular functions, such as invasion and apoptosis that may vary depending on different gene profiling. Gene profiling is basically a way to categorize cancers, but if we can categorize them in functionally relevant ways, then we are really making advances.

This takes studying large numbers of patients, ideally in the context of a clinical trial where they are being treated similarly or we are comparing 1 treatment with another. Then, we can dissect the different molecular profiles that may predict a benefit. More importantly, we can use that information about the molecular profiles to identify mechanisms of resistance that could inform newer strategies.

Not all mutations are the same. There may be certainESR1mutations that are generated in certain situations and under certain treatments that we need to understand better. What is really fascinating is trying to understand the functional consequences of ESR1 mutations, not only in terms of proliferation, but in terms of many other phenotypes that we are interested in targeting, such as metabolic activity, DNA repair, or other hallmarks of cancer. Whether it is invasion, the ability to resist apoptosis, or immunogenicity is critical. Studies in the basic aspects of what ERS1 mutations do [are important]. [Also, evaluation of] the nitty gritty molecular structure and how the ER interacts with co-activators, co-repressors, and other aspects of the transcriptional machinery that make the ER work [is needed] to understand what ESR1 does.

Of course, we are aware of many other mutational isoforms, such asRASmutations and growth factor mutations, like exon 20. We need to understand the inner workings of what these mutations cause. When you think about it, cancer is selection of the fittest. Cancer cells do have a higher mutational rate. Many of the mutations that arise out of accident lead to cell death. However, it is those that lead to cell advantage that perpetuate. By understanding the most common driver mutations that arise over time, we can start to develop therapies against each one. Although, there will always be rare mutations that are going to be more difficult to understand and target.

Link:
Lasofoxifene Emerges as Understanding of ESR1 Mutations Expands in ER+/HER2- Breast Cancer - OncLive

PLATTSBURGH We have all experienced grief and loss this year, Bonnie Black says.

That ranges from loss of junior prom and vacations, to not working in your office and having to give up typical holiday experiences due to the COVID-19 pandemic.

This is all new; it isnt a choice we made, said Black, director of Employee Assistance Services at Behavioral Health Services North.

It was foisted upon us due to the pandemic, and there wasnt much notice.

NEED HUMAN CONNECTION

Remote learning, contemplation of what defines essential workers and isolation have been part of this shared human experience brought on by the coronavirus, Black said.

Look at these holidays: Hanukkah, Christmas, Kwanzaa, New Years. A good number of us connect physically with family or friends. We have not had the human touch, the human hug in so long.

Were social animals, we need a human connection.

Studies conductedthis year demonstrate the resulting negative impacts on human lives, such as increased anxiety, depression and substance misuse.

We are all empathizing with loss, grief, uncertainty, and all of that produces stress, which produces cortisol, Black said. When our cortisol hormone is increased, we have very negative physiological impacts on our heart, kidneys, brain function.

So we need to look at how do we stay resilient.

SLEEP, REDUCE SUBSTANCES

Black first recommends ensuring quality sleep; adults should get seven to nine hours most nights.

Our brains do their work when were sleeping. Thats why we need sleep, to let the brain reorganize itself.

Over the holidays especially, people should reduce the amount of substances they choose to use, perhaps subbing in something like sparkling grape juice, Black said.

We have to be very careful because our bodies and brains are really experiencing an immense of amount of stress that theyre not used to.

GRATITUDE, EXERCISE

Black additionally advised looking for moments of gratitude and joy, even if its just two squirrels playing in your backyard.

Smiling and laughter results in the release of endorphins, which help destroy the cortisol produced by stress.

Apps like Headspace or Calm, a podcast that you enjoy and exercise can also do the trick, Black said.

And exercise helps people to connect with nature.

We did it almost instinctively last spring: everyone went to Lowes or Aubuchon and bought landscaping materials, tools and made plans," Black said.

We got out into nature, the dirt under the fingernails that made us feel good.

CONTROL, SYSTEMS

Looking ahead to maintaining those yard projects and just starting to plan and make lists are helpful tools, Black said.

We believe weve lost control, and we have lost some.

What do you have control over? What is very important every day?

Control may look as simple as getting dressed and going downstairs for breakfast each day, deciding which days are laundry or trash days, or taking time to reach out to one person one day a week, Black said.

We havent had to think of life like that, but when we have a system and have control, whatever the system may be, our brains and our bodies can actually relax and be in a less stressed state.

That also involves monitoring consumption of news media, which largely does not create endorphins that reduce stress, she added.

Because we cant control our external world much, we need to find ways to control our internal world. When we put our head to the pillow, whats the one thing we can be grateful for, how many people smiled at me, how many people did I smile at.

REACH OUT

Black said suicide rates are going up, even though they normally go down this time of year. She noted in particular increases in attempts and deaths by suicide among first responders, firefighters and police.

We have to be very, very aware that there are some people under some really undue stress, stressors they never really signed up for."

Reaching out to people feeds into the human connection that everyone needs, Black said.

If you havent seen somebody at work or school or they havent been on the Zoom call, shoot an email, shoot a text.

You be the one to reach out. You could bring that moment of joy to their life that they havent been able to find or see.

Zoom or Facetime conversations, or short emails, videos or messages can say many things.

I like you. I remember you. I want to be connected with you, Black said.

Thats the gift we can give that, monetarily, does not cost us anything but fulfills that need for human connection.

Email Cara Chapman:

cchapman@pressrepublican.com

Twitter: @PPR_carachapman

WHERE TO GET HELP

Seek help if youre considering suicide.

For emotional crises:

National Crisis Text Line: 74141

Text: GOT5 to reach a crisis counselor in New York State.

The toll-free 24-hour North Country Crisis Helpline number is (866) 577-3836. That number is answered by members of the Clinton County Mobile Crisis Team Monday through Friday from 8:30 a.m. to 7:30 p.m. Outside those hours, it is answered by an on-call crisis service.

Out-of-county calls are accepted but other options are:

The National Suicide Prevention Lifeline, (800) 273-TALK (8255). Press 1 for confidential help for veterans and their families.

The Essex County Mental Health Association Hope Line, (800) 440-8074. That number is staffed 24-7; leave a message and your call will be returned within 10 minutes.

Visit the Clinton County NY Coalition to Prevent Suicides Facebook page for education and resources.

If a friend of yours posts suicidal content on Facebook, let someone know an adult, the police. And visit http://tinyurl.com/nuvnm29 to report it.

National Alliance on Mental Illness: Champlain Valley is a resource for suicide-survivor support. Call (518) 561-2685.

For counseling, contact:

Clinton County Mental Health, (518) 565-4060.

Behavioral Health Services North Adult Clinic, (518) 563-8000 (staffed around the clock).

Essex County Mental Health Clinic, (518) 873-3670; after-hour emergencies, (888) 854-3773.

In northern Franklin County, around the clock, (518) 483-3261; southern Franklin County, (518) 891-5535.

Additional resources, such as for parents and educators, are available on the Mental Health Association of New York State's website,mhanys.org.

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Tips for mental health resilience in the time of COVID - Plattsburgh Press Republican

Testosterone is an important hormone in males, contributing to many aspects of development, which is why low testosterone can be so noticeable.

During your teenage years, testosterone initiated your facial hair to start growing, your voice to deepen, your muscles to strengthen, and your sperm to start producing. As you reached adulthood, your testosterone production plateaued and began to decline.

While the decline is normal, your testosterone may have dropped lower than expected, leading to some unwanted symptoms.

Understanding low testosterone

Low testosterone, also known as Testosterone Deficiency Syndrome, happens when testosterone production dips below what your body needs to function normally.

In healthy males, a normal level of testosterone in the blood is between 350 and 1,000 nanograms per deciliter, according to viTal4men testosterone replacement therapy clinic.

So, how will you be clued into low testosterone levels? Here are a few symptoms you may have noticed, according to the American Urology Association:

Low testosterone is not the only culprit behind these symptoms, as other issues such as diabetes, drug use, and obesity may be at play.

To help narrow it down, some specific symptoms are associated with low testosterone, according to WebMD:

Another term for the natural decline in testosterone over the years is andropause which, like menopause, can affect your mental state, as well. For example, you may be moody or depressed and have a hard time concentrating. You may also have trouble sleeping and low energy and motivation during the day.

What you can do

When your low testosterone is connected to a medical or lifestyle issue, treating those causes can improve testosterone production. In other cases, low testosterone may not have an easily identifiable cause.

Fortunately, diagnosing low testosterone is as simple as taking a blood test, which viTal4men offers for free, along with a 10-to-15-minute consultation with a medical practitioner who specializes in treating low testosterone.

At the viTal4men Clinic, we treat low testosterone levels with testosterone replacement therapy to get you back to your optimum level, viTal4men says.

Testosterone replacement therapy will help raise and maintain your testosterone levels with options that you and your provider will choose, based on what works best for you. These may include gels, patches, injections, oral medication, or surgically implanted pellets.

Injections are one of the most common and effective methods, as the right dosage will lead to improvements in energy, muscle mass, sexual desire, and verbal memory, along with a decrease in body fat about three weeks after treatment. Your depressive symptoms may improve as well, although that can take about 18 to 30 weeks to kick in. Throughout the process, youll need to continue receiving injections every 7 to 9 days at 15-minute consultations.

In addition to testosterone therapy, viTal4men offers discount erectile disfunction medication; services for diabetes, cholesterol, and blood pressure management; fat-burning B12/MIC injections; flu vaccines; wellness exams; and other general health care. The clinic accepts most major medical insurances.

For more information and to make an appointment for your free testosterone level test, visit Vital4Men.com.

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Do you have symptoms of low testosterone? - KTAR.com

At the onset of the COVID-19 pandemic, now-familiar symptoms like diarrhea and a loss of smell or taste hadnt yet been confirmed; now, theyre hallmark signs of the illness. Although we know much more about the novel coronavirus now than we did months ago, doctors are still discovering new side effects of infection, including hair loss and lingering fatigue. The latest discovery? Research points to a surprising link between COVID-19 and erectile dysfunction (ED), the inability to obtain and/or maintain an erection for satisfactory sexual function.

A review of research published earlier this year was the first to note a correlation between survivors of COVID-19 and ED, plus evidence of other sexual and reproductive issues in recovered men, both short- and long-term.

The virus causes your body to have a very strong [immune] response, which can impact the cardiovascular system, circulation, and the heart, explains Anthony Harris, M.D., M.B.A., M.P.H., CIO and associate medical director for WorkCare.

Any major stressor can disrupt your normal hormone function, which can, in turn, completely obliterate the libido, says Amin Herati, M.D., director of male infertility and mens health at the Brady Urological Institute and assistant professor of urology at Johns Hopkins University. Since COVID-19 infiltrates so many different parts of the body, from the skin to the brain, experts say its no surprise that ED could be a lingering effect, even post-recovery.

The causes of ED vary widely. Psychologically, there must be arousal; physiologically, the brain and body need to release the proper compounds to initiate an erection; and physically, the penis must be able to become erect.

Its like a car, Dr. Herati says. There has to be a desire to get in the car, plus a key in the ignition and gas in the tank. Long story short: Lots can go wrong along the way. And when the novel coronavirus starts to replicate in the body, the resulting illness can mess with every piece of this system, from blood vessels to testosterone levels, resulting in ED.

Any major illness that affects the body can [cause ED], but COVID-19 has this strong systemic, inflammatory response that really drives the hormones down, Dr. Herati notes. When hormone levels drop, guys will notice reduced spontaneous nocturnal and morning erections. That loss of desire for intercourse, and also the diminished spontaneous erection, is something that some guys have noticed with COVID-19.

Remember that strong immune response? Dr. Harris says it also affects your blood vessels, heart, and lungs, and that impact can affect your erection. (In this case, the driver might want to get moving, but the car wont start.)

COVID-19 attacks blood vessels, and symptoms caused by this complication of the virus have been well-documented over the past few months. Blood clots in the lungs, for example, can cause intense breathing issues, while clots closer to the skins surface can cause COVID toes. If blood flow is weakened or blocked by COVID-19, ED could be one of the ways that underlying issue presents itselfafter all, a healthy erection requires healthy blood flow.

And in a more general sense, weaker overall health caused or aggravated by the virus could also play a role. Men with poor health are at greater risk for developing ED and also for having a severe reaction to COVID-19, per the Cleveland Clinic. For instance, ED could point to underlying issues with the heart or circulation, especially when combined with COVID-19. If youre barely getting enough blood to other parts of your body because of clotting or a weakened heart, achieving an erection will be difficult.

Beyond the physical effects, the mental toll of recovering from the virus might play a role in suppressing libido. There is a very strong association with [ED] and the psychological effects from COVID, Dr. Harris says. We have to be aware of that.

For certain people, recovery is not so simple. So-called long-haulers, or people who have technically recovered from COVID-19, but still experience long-term symptoms or side effects, could be particularly at risk for ED caused by psychological distress. Depression, anxiety, and fatigue can all destroy the sex drive, leading to reproductive issues.

Until COVID-19 has been around long enough to study its long-term effects, experts cant be sure which symptoms are most likely to lingeror who is most at risk for prolonged illness.

But there is some hope. Testosterone levels often rebound to their normal levels once a temporary illness has passed. To my knowledge, there is no data that says that COVID-19 affects the [structures of the penis], Dr. Herati says. With hormones replaced and blood vessels intact, ED could be a short-term issue.

Still, there is no guarantee. I can give you a solid I dont know, Dr. Harris says. We dont know how long these effects will last prospectively, but weve seen them last for three months, six months, or even longer. Like with neurological and cardiovascular symptoms, there simply isnt enough research yet to determine how long patients can expect ED to last after COVID-19.

Whether or not COVID-19 directly causes ED, the two conditions are at least correlated. (Other adverse effects like permanent lung damage, chronic fatigue, and even death, however, are confirmed side effects of the illness.)

But it is crucial to note that theres no evidence that the COVID-19 vaccine causes ED. Its side effects are akin to those of the annual flu shot, which is also encouraged by medical experts. Avoiding ED could be reason enough to seek out the vaccine. This is why men should go get vaccinated, Dr. Harris says with a laugh. Its worth it.

COVID-19 is a serious illness, and your first step should be addressing serious symptoms and side effects, like shortness of breath or heart problems. Compared to these complications, ED should hit the bottom of the priority list. (Keep in mind that when youre sick, you might not be in the right mental state to maintain an erection, either.)

But if youve recovered and youre still experiencing ED, its a good idea to chat with your doctor. They will be able connect you with a urologist, who can help determine the cause of your ED and offer potential solutions.

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Why COVID-19 Might Lead to Erectile Dysfunction in Some People, According to Doctors - Prevention.com

Irving, Texas. December 17, 2020

Las Colinas Cancer Center is a recognized leader in clinical research and personalized cancer care with their state-of-the-art equipment, facilities and specialists dedicated to providing the utmost cancer care to patients. The center provides cancer care to patients with various types of cancer, including colon, breast, and lung cancer.

The team at Las Colinas Cancer Center is committed to providing the personalized, compassionate cancer treatment that will make all the difference in cancer care. Their state-of-the-art facility located in North Texas provides those battling cancer and blood disorders a haven to get professional care from some of the nations most experienced oncology specialist in a supportive, caring environment with an integrated approach to treatment.

Las Colinas Cancer Care offers customized treatment programs integrating the most sophisticated therapies, including hormone therapy, chemotherapy, external beam radiation therapy, radiation therapy, such as MammoSite therapy, a five-day targeted radiation therapy that results in a much lower recurrence rate and improved cosmetic results. Professionals at the cancer center work together with patients to design a specialized treatment plan.

The center ensures that their patients care is unmatched with its cutting-edge technology,diagnostic and cancer treatment equipment. The clinic provides various cancer treatment options. They understand that cancer therapy can include multiple modalities that work together to fight cancer and improve life depending on the particular situation. The cancer treatment options include; cancer surgery, radiation therapy, spiritual support, complementary and integrative medicine, and more.

Las Colinas Cancer Center has built a long-standing reputation as an exceptional medical oncology cancer treatment center committed to delivering their patients with the best, modern, and advanced cancer care that includes state-of-the-art radiation oncology treatment using high precision stereotactic radiosurgery. The clinic also offers prostate seed implant therapy, a non-invasive method where seeds are placed directly into the patients prostate to target cancer. The procedure is fast and comes with very few side effects, allowing patients to recover faster and resume their everyday routines.

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Las Colinas Cancer Center is Recognized as a Leader in Clinical Research and Personalized Cancer Care - Irving Weekly

In a year upended by COVID-19, it seems like our immune systems have received more attention than ever before. But many unhealthy behaviors brought on by the pandemic make it harder for our bodies to fight off infections.Here are some tips on maintaining a balanced immune system that can protect you this winter:

The first line of defense is a healthy lifestyle. These factors can put you at risk:

Eating too much, or too little, can be harmful. Make sure that you include enough healthy foods in your diet, and avoid consuming too many items that are low in fiberor high in fat, salt and/or sugar. Unhealthy eating can contribute to the risk of developinghealth problems and even some illnesses:

No supplement will cure or prevent disease. However, aproper diet can help prepare the body to better fight disease.

"The thing about foods is that they combine a bunch of nutrients and vitamins into a complete package," said Sandra Darling, a preventive medicine physician at Cleveland Clinic."You can't extract one compound like antioxidant green tea and just take that one compound and expect to have benefits. It doesn't work like that."

Make sure to include fresh fruits and vegetables in your daily diet. Don't forget about whole grains and nuts.

Vitamin C can stimulate the production of white blood cells, which are key to fighting infections.Citrus fruits, strawberries, red bell peppers and kiwis are richin vitamin C.With such a variety to choose from, its easy to addfoods high in this nutrientto any meal. However, high doses of some vitaminscan be toxic, especially when taken regularly.

Beta carotenefunctions as anantioxidant, a compoundthathelps defend your cells from damage caused by potentially harmful molecules called free radicals. Eating a diet rich in antioxidants can help reduce risk of chronic diseases and boost health. Carrots, sweet potatoes, spinach, and broccoli contain high amounts of beta carotene. Vitamin A, which the body creates from beta carotene,helpsthe lungs work properly in addition to other benefits.

Studies have shown that compounds in garliccan boost the disease-fighting response of some types of white blood cells in the body when they encounter viruses. Eating it while you are sick can help decreasehow long you stay sick and reduce the severity of symptoms. Garlic can also lowerthe risk of becoming sick in the first place.

Ginger may help decrease inflammation andrelieve congestion. It may alsosoothe nausea and digestive issues. Don't focus too much on the particular foods or supplements, but make sure are getting a sufficient amount of all the necessary nutrients from healthy foods in your diet.

Health-promoting bacteria in the colon are also animportant part of the immune system, Darling said. Focus on high-fiber foods, and specifically foods that contain the type of fiber called inulin. Good sources of inulin include artichoke, asparagus, and chicory root. Yogurt contains live and active cultures or probiotics. Try to choose the low-fat plain kindrather than theflavored varieties that can be loaded with sugar.

Don't forget to drink plenty of water.Try to avoid snacking irregularly. If you do snack, choosefresh fruits and raw vegetables rather than foods that are high in sugar, salt or fat.

"Pack carrot sticks, pack almonds,"said Erin Michos, preventive cardiologist at the Johns Hopkins Hospital."I'm a snacker, so I'm not going to tell you not to snack. I am just going to say snack on things that are good for your body, that boost your immunity."

It's important to maintain yourweight within healthy ranges. One of the measures that can help in measuring and interpreting yourweight is body mass index(BMI).BMI from18.5 to 24.9 is considered to bewithinhealthy range. Fat cells are not justpassive reservoir of energy, but canactually secretehormones thatincrease inflammation making overweight people more vulnerable to diseases. Making meal plans and schedulingfood intakesin advance can help to keep weight under control, especially if you are working remotely.

Studies indicate that sleep plays a crucial role in the functioning of the immune system. Breathing and muscle activity slows down, freeing up energy for the body to fight off illness. Sleep is important forimprovingT cellfunctioning. T cellsrespond to viral infections and boost the immune function of other cells. Cytokines, a type of protein in theimmune system that target infections,are also produced and released during sleep.Studies have also shown that sleep even improves the effects of vaccines.

The American Academy of Sleep Medicine and the Sleep Research Society recommend that adults aged 1860 years sleep at least sevenhours each night. According to the Centers for Disease Control and Prevention, 1 in 3adults dont get enough sleep.

Insufficient sleep makes it more likely one willcatch the common cold or the flu. A study showed that people whosleep less than six or seven hours per night have a higher risk of infection in a short term.

Researchshows creating a good sleep routineis essential for a good nightsleep and helping your immune system. Limit the amount of caffeine and alcoholyou consume before bed. Alcohol can make you sleepy, but can affect your sleep cycle. Caffeine can cause you to you feel wired, making it hard to fall asleep. Darling recommends avoiding electronic screens for at least 60 minutes before sleep.

Create a sleep schedule. Havingconsistent cues before bed can playa large role in your nighttimeroutine. Brushing your teeth, readinga bookand other activities can give your body signsit's time foryou to wind down for the day.

Moderate exercise improves cardiovascular health, lowers blood pressure andhelps control body weight. It also promotescirculation of the cells and substances of the immune system, which allows them to move through the body freely and do their job efficiently. It may reduce inflammation and help your immune cells regenerate regularly.

Unfortunately, only about 1 in 5 adults and teens get enough exercise to maintain good health, according to American Heart Association.Here is how lack of activity can affect the body and lower your immune response:

Moderatephysical activityis recommended during the pandemic and can also combat obesity, heart disease and diabetes. Health experts recommend a moderate-intensity exercise routine, two to three times a week,for up to 45-minutesfor good immune health. Try to aim for at least 150 minutes of moderate exercise per week, or 30 minutes, five days a week. Maintaining continued exercise routinemight be particularly essential for the elderly.

However, avoid pushing yourself too hard for too long.Prolonged (more than 1.5 hours) intense exerciseperformed without food intake can temporarilysuppress your immune system,providing the opportunity for infections to take hold. To determine whether the exercise is moderate or vigorous, you can use the "talk test."

"When you're doing a moderate activity like brisk walking, you can talk but you can't sing," Darling said."And then if you are doing vigorous physical activity, likeswimming laps, or jogging or playing tennis, you would not be able to talk or sing."

As the pandemic continues, many people have been experiencingvarious levels of continued stress. Nearly 8 in 10 adults say the coronavirus pandemic is amajor source of stress in their life.

Stress causes your body to release cortisol, the body's primary stress hormone. Increased cortisol levels in the bloodstream can cause inflammation, which altershow your body's immune system responds toinfections. Moreover, long-term inflammation promotes imbalances in immune cell function and can evensuppress immune response. Children and the elderly are particularly vulnerable to the effects of stresson immune system.

According to Johns Hopkins Medicine,controlling your stress is key to improving your immune system. Here's a look the impact stress has on the body:

Once you know your triggers workloads, kids or relationships you can makesmall changes can help manageyour stress levels. Here are a few modification to help reduce your stress:

If you can't minimize stress, make sure to have acoping mechanism that works for you, says Michos, the preventive cardiologist from Johns Hopkins. Some of the activitiesthat may help you manage your stress includemeditation, exercise, journaling, yoga, and other mindfulness practices. Stay away from adverse coping mechanisms like smoking or drinking too much alcohol. Smoking can actually weaken your body's defenses.

Ifyoure experiencing a mental health crisis or having thoughts of suicide, go to an emergency room, call the National Suicide Prevention Lifeline at 1-800-273-8255or visit the National Alliance on Mental Illness site,nami.org,for additional resources.

Overall, maintaining a balanced diet, getting enough sleep, engaging in regular physical activity, and keeping stress down are some of the most important ways to help keep your immune system healthy and reduce your chances of infection and disease. Take it easy, take a walkand put down those smokes.

However, don't go overboard. Too muchimmune response can causeimmune system to malfunction as well.

"You've probably heard about autoimmune diseases like lupus or rheumatoid arthritis, or even in COVID, where the immune system might go overdrive," Michos said."So, we don't wanthyperimmunity either. What you're talking about is trying to have overall balance, so everything is working in check."

It's also important to keep wearing mask in public, maintaining social distancing and sanitizinghands before touching face. These measures will help you to avoid exposure to novel coronavirus and flu viruses, among others.

SOURCE Healthline.com; John Hopkins Medicine; Mayo Clinic; Stress.org and USA TODAY research

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How to strengthen your immune system this winter - USA TODAY

Vitamin D is certainly enjoying its moment in the sun. Not only has the vitamin been highlighted lately for its potential role in COVID-19 severity, but now new research suggests it may be linked to a healthier gut microbiomea critical part of your immune system function, hormone regulation, and bone health.

Published in the journal Nature Communications, the research looked at data from 567 men participating in a larger study on osteoporotic fracture risk.

Researchers used rRNA sequencing to identify the types of bacteria present in stool samples, and compared it to vitamin D levels in blood serum samples. Those researchers found that participants with more active vitamin D also had higher overall microbiome diversitywhich is considered essential for better gut health.

So, whats the connection? According to senior study author Deborah Kado, M.D., director of the Osteoporosis Clinic at UC San Diego Health, its all about a substance called butyrate. If you have a healthy gut, Kado said, your beneficial bacteria produce more butyrate, which is basically the by-product made when fibers are broken down by those happy bacteria. Butyrate leads to an increase of vitamin D. So, the more you have, the more D you absorb.

But heres the catch: The word active is more important than it might seem, because you can be getting enough vitamin D from sunlight and supplements (the National Institutes of Health recommends 600 international units [IU] per day), but if your body isnt metabolizing that, you wont get the benefits the vitamin providessuch as building and maintaining bones, increasing lean body mass, boosting aerobic fitness, and improving your immune systemaccording to Kado.

The good news is that its likely you can boost how much vitamin D youre absorbing through healthy habits, she told Runners World.

Gallery: 13 Healthy Foods That Boost Your Memory, According to Nutritionists (Eat This, Not That!)

It seems plausible that we can make lifestyle changes to maximize our gut bacterial health that will, in turn, help our overall health.

In addition, as your gut function improves, your vitamin D absorption will, too.

There are many aspects of good health that can optimize vitamin D signaling, Kado said. The easiest is ensuring you get plenty of fresh fruits and vegetables of many different colors in your daily diet. Not only will this provide important vitamins and minerals, but will also promote a nourishing environment for healthy gut bacteria.

Although the study results only included older menand Kado cannot say for certain that women and younger people would have similar outcomesshe does believe that based on previous research, its likely everyone would experience the same association between vitamin D and gut health.

The takeaway? Feed your gut rightand that includes regular exercise, research findsand youll strengthen that vitamin D absorption.

The health of the bacteria in our gut relate to being able to maximize vitamin D metabolism in our bodies, Kado said, and thats important for a range of health benefits, including osteoporosis and immune function.

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You Might Not Absorb as Much Vitamin D as You ThinkHere's How to Maximize the Process - msnNOW

WRIGHT-PATTERSON AIR FORCE BASE, Ohio The COVID-19 pandemic has led to implementation of unprecedented physical distancing strategies crucial to limiting the spread of the virus. While the most immediate threat from COVID-19 is the physical health of those infected, the pandemic will also have wide-ranging effects on the social and mental health of others living through the crisis.

Social isolation occurs when an individual does not have adequate opportunities to interact with others. Physical distancing and isolation can present certain challenges, such as spending days or weeks at home with limited resources, stimulation, and social contact.

According to the Centers for Disease Control and Prevention, social isolation can threaten health, and regular social interactions and having a strong personal network are important to a persons mental and physical health, resilience, and longevity. Health concerns stemming from social deprivation include high blood pressure, sleeplessness or less restful sleep, anxiety, depression, and thoughts of suicide. In addition, lack of human interaction may increase hormone levels that contribute to inflammation and weakened immunity, thereby increasing the risk of diseases.

Although it remains critical that we follow physical distancing requirements to combat the spread of COVID-19, it is equally important that we remain socially connected with our family, friends, colleagues, and community to prevent the negative health outcomes caused by being socially isolated and lonely. The following are some strategies for feeling more socially connected during this time.

If you are struggling with chronic loneliness, hopelessness, anxiety, or depression, you are not alone. With professional support, you can improve your mental wellbeing and enjoy life again.

Professional counseling services are available for the AFMC workforce and their families.

Civilian employees may contact the Employee Assistance Program for free, confidential counseling services at 866-580-9078 or visit the EAP website at AFPC.af.mil/EAP.

Military members can contact their local mental health clinic for services. Military OneSource is another option for military and their families. For more information, call 800-342-9647 or visit militaryonesource.mil.

For more information on coping with social isolation and loneliness, visit the Civilian Health Promotion Services video library at USAFwellness.com. Substance Abuse and Mental Health Services Administration also has an informative PDF Taking Care of Your Behavioral Health with advice for managing social isolation under quarantine.

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Coping with social isolation | News | standard.net - Standard-Examiner

During a breast self-exam two months ago, I felt a lump. This month, the lump seems to have disappeared. My cousin, who had breast cancer, is suggesting I get it checked anyways. I'm nervous to go to the doctor because of COVID-19. Is it safe to get a mammogram and other breast cancer screenings, or is it OK to wait, even with a family history?

As a woman, you know your body better than anyone, including your health care provider, so taking time to do breast self-exam is important. Finding a lump in your breast can be scary and cause anxiety. And with the COVID-19 pandemic continuing, I can appreciate your concerns about safety.

Mayo Clinic is taking many precautions related to COVID-19, and we are committed to ensuring the safety of our patients and visitors. The risk of contracting COVID-19 from coming in for a screening, such as a mammogram, is very low. Though many people may tell you that waiting a week or two for a breast cancer screening will not cause significant issues, I believe that delaying screening or delaying seeking medical attention can make a difference in terms of treatment if cancer is detected.

Keep in mind that a self-exam of the breast can be difficult for some women, depending on their breast consistencies. Some women might have lumpy breasts, and it might be difficult to discern which lump is cancer and which one is not. So a breast self-exam is good, but it's not enough. In my opinion, it is important to see a health care professional for diagnosis.

It is also important to note that different ethnic groups get different kinds of breast cancer. Young African American women and Latinas more commonly get the aggressive form of breast cancer called triple-negative breast cancer. Unfortunately, there are not a lot of targeted treatments that can be used with these women. So if you are an African American or Latina woman, that is another reason for you to seek medical attention as early as possible.

If breast cancer is detected early, such as in stage 1 or stage 0, the likelihood is that the cancer is highly curable. But if you wait until the cancer starts to grow, especially if it starts to spread to the lymph nodes, then the cure rate is much lower. If it starts to spread somewhere else in the body, then it may become incurable. In addition, treatments for patients with stage 0 or stage 1 breast cancer are often simpler. These patients often only require surgery, radiation and endocrine therapy. Chemotherapy usually is required for patients with more advanced disease, with a larger tumor or lymph node involvement.

In the past few months, I have seen a few women who reported finding a lump in their breast back in February or March at the beginning of the pandemic. Due to their concerns about COVID-19, they decided to wait to seek medical attention. In one patient, the mass continued to grow. She now has cancer growing through her skin, and it has become difficult to treat. I would encourage you if you feel anything different in your breast compared to what it was previously to seek medical attention right away.

Depending upon your situation, in addition to the traditional mammogram, there also is tomosynthesis, which is the 3D mammogram that can provide clearer images for women with dense breast tissue. Additionally, your health care professional also might order a breast MRI, which is the most sensitive test and looks at all of the breast area, including regional lymph nodes around the breasts.

The other benefit to visiting a health professional sooner rather than later is to discuss your personal risk and what, if any, preventive measures might be valuable based on your family history.

There are ways that we can calculate the risk of breast cancer in each patient. Currently, there are multiple models used. Some of these models include Gail's model and another called the Tyrer-Cuzick model. These models take into account your age at menarche, how many children you have and if you had a previous breast biopsy. All of those things can be plugged into the calculation. Then it will come up with your estimated lifetime risk of breast cancer and the best screening mechanisms for you.

If you meet certain criteria, such as in the Gail's model, and if your risk is more than 1.66% in five years, that would qualify some patients to receive medication to prevent breast cancer. In other words, the hormone blockers that are used to treat patients who already have breast cancer also can prevent breast cancer from happening in high-risk patients. These medications can cut down the risk up to almost 70%.

Being proactive and doing a monthly breast self-exam is a great first step for maintaining overall health. Regardless of COVID-19, I would encourage you to reach out to your primary health care provider to set up a screening appointment and get an answer about the lump you found.

Dr. Saranya Chumsri, Medical Oncology, Mayo Clinic, Jacksonville

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Breast cancer screening and COVID-19 | Feeling Fit - yoursun.com

By Dr. Mary Jane Minkin, Clinical Professor, Department of Obstetrics, Gynecology and Reproductive Sciences, Yale University School of Medicine

In so many of my daily conversations with patients, colleagues, and friends, there is almost always a moment when someone exclaims I wish men knew how to support their female partners better when it comes to menopause. From those conversations, Ive discovered a constant theme: women living through menopause just want to know they are not alone, that they can speak about their experiences openly with their partners, and that they will be supported and loved. Normalizing menopause is the most important way a man (or anyone, really) can support a partner or the women in their life going through it, and there are myriad ways to treat many of the infamous symptoms caused by menopause that have unnecessarily and unjustly shrouded mid-life women in silence and shame.

For too long, the word menopause was whispered or quietly referred to as the change or the m worda phase of life when women were said to be irrational, irritable, cold, and sexless, some of the worst of the false stereotypes. Archie Bunker famously referred to menopause on national TV as Ediths Problem. It was certainly groundbreaking material for the 70s, but attitudes havent changed enough with the times. Recent studies show that despite plenty of progress, only 30% of women report talking about their menopausal symptoms with their healthcare provider, and 50% of women feel that the topic is taboo. It often takes women and their partners a while to acknowledge that changes to their mental health, sex drive, and body as they reach mid-life may be due in large part to the menopausal transition and not necessarily the relationship.

Little research has been done around mens attitudes or understanding of female menopause but studies are emerging. A 2019 survey, published in the Menopause: the Journal of the American Menopause Society, found that 63% of survey respondents reported that their partners menopausal symptoms had affected them personally, including emotional strain (34%), reduced frequency of sex/intimacy (33%), and trouble sleeping (10%). This proves male partners are aware of their female partners menopausal transition, but they are less aware of how to be supportive. In the same survey, less than half of the respondents knew there were treatments available for menopausal symptoms.

Destigmatizing menopause starts with knowing the facts. According to the Mayo Clinic, menopause is a natural biological process that a woman officially reaches when she has gone 12 months without her period, signaling the end of her reproductive years. In the years leading up to menopause, called perimenopause, the ovaries produce less and less estrogen, the hormone that regulates the female reproductive system, until the ovaries are no longer active. As a result of declining estrogen and other biological changes, women in perimenopause may experience a range of uncomfortable symptoms like hot flashes, difficulty sleeping, brain fog and other cognitive challenges, depression, and loss of sex drive. Women also often experience vaginal dryness, pain with sex, and other changes to their pelvic health. They will also be at higher risk for osteoporosis, heart disease, and other health problems.

The good news is that there are many safe hormonal and non-hormonal treatments and lifestyle changes that can mitigate menopausal symptoms and help women and their partners maintain a healthy relationship. The biggest barrier to these treatments is STIGMA. For a start, men can tell their partners that they love them unconditionally and will support them as they speak with their doctor or medical providers about treating their symptoms. They can also offer to join their partner for an appointment or telehealth conversation or help them develop a list of questions to ask. Regular exercise; holistic practices like yoga and meditation; eating a healthy and balanced diet; and taking calcium and vitamin D can also help to ease menopausal symptoms and create mutually beneficial opportunities for partners to spend time together and reconnect.

And yes, aging will change sex for both partnersregardless of gender!but there are many ways to keep things vibrant. Most importantly, men should let their partners know how much they love them and keep the lines of communication open. Be aware that intercourse may become painful or uncomfortable for a perimenopausal or menopausal woman through no fault of her own. Reassuring your partner that its okay is crucial to her self-confidence. A womans medical provider can recommend hormonal and non-hormonal treatments, medications, and devices to help with arousal and desire, and potentially refer her to a pelvic floor specialist if the pain is severe. There are many over-the-counter lubricants and vaginal moisturizers available as well.

Most importantly, find ways to have amazing sex that honor your partners body where it is. Most womenage notwithstandinghave their best orgasms without intercourse. And remember, it does take two to tangomen will endure changes to their sex drive as they age too. There is increasing evidence that men go through their own menopause of sorts. Both partners need to be open with their doctors for guidance on how they can address aging-related issues like erectile dysfunction and decreased energy and desire.

Menopause is not a time to check out and be afraid to broach the topic or become resentful. Ideally, a man who is involved and supportive can make a big difference for his partner going through the menopausal experience and in the relationship. Reducing the stigma about menopause and normalizing the conversation and the experience will go a long way.

Dr. Mary Jane Minkin is a practicing gynecologist, with a special interest in menopause. She is a North American Menopause Society Certified Menopause Clinician. Dr. Minkin is also the co-director of the Sexuality, Intimacy and Menopause for cancer survivors program at the Smilow Cancer Center. She has taught at Yale University School of Medicine for over 41 years, and is a clinical professor of obstetrics, gynecology and reproductive sciences.

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A Time to Man-Up: Supporting the Menopausal Women in Your Life - The Good Men Project

Ever feel like you have an endless craving for all the junk food salty, sweet or both that you can get your hands on?

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You just cant seem to give it up and keep eating, especially during times of heavy stress. And theres certainly been plenty of stress to keep us hitting the bags of chocolate the last several months.

Especially when were stressed, junk food often soothes us with the least amount of fuss and effort. We look for sugary and fatty foods to make us feel good, says registered dietitian Beth Czerwony, RD. But there are ways to get control of your food cravings, instead of them controlling you.

Junk food is food that is unhealthy for you, just as the word junk implies. It runs the gamut from sickly sweet (think: cookies, candy and cake) to heavy on saturated fats (think: fried and processed foods). Eating too much junk food can have short- and long-term consequences for your body thanks to these ingredients.

Eating foods rich in saturated fats can increase your cholesterol levels and the amount of plaque in your blood vessels. If you have blood vessels that are stiffening and not moving blood effectively, you have a higher risk for heart disease, including heart attacks and strokes, says Czerwony.

Too much sugar in your diet can lead to weight gain, a risk factor for diabetes. Some animal studies also suggest that artificial sweeteners make our bodies resist insulin. This may also increase the likelihood of developing prediabetes, diabetes and heart disease.

Most Americans are walking around with prediabetes, putting them at risk for developing Type 2 diabetes, Czerwony adds. Once you have diabetes, doctors treat you as if youve already had a heart attack because the rate of heart disease is so much higher. All of these health issues affect all the organs, so its important to get a handle on them.

Czerwony lists four reasons you may be craving sweets and other junk food.

Unfortunately, our bodies are hard-wired to crave junk food. When you eat foods you enjoy, you stimulate the feel-good centers in your brain, triggering you to eat even more.

Especially in patients with excess weight and obesity, the brains reward processing system for food is like its mechanisms related to substance abuse. Sugar makes us want to eat more sugar. Fat makes us want to eat more fat, notes Czerwony. Our brains are chasing that pleasurable state of food euphoria.

Studies suggest that sleep deprivation is associated with increased hunger (especially snack and sweet cravings). And you can blame it on your hormones. Lack of sleep causes hormone shifts:

If its normal for you to eat junk food, it can be hard to break that cycle, explains Czerwony. Youre used to not cooking, preparing or planning. You eat whatevers on hand because thats what youve always done.

Stress, or emotional, eating really is a thing and its the result of both nature and nurture.Some people find food helps distract them from negative thoughts and feelings. Others learned as children to use food to cope.

Hormones are also responsible. Like lack of sleep, ongoing stress causes the body to increase levels of cortisol and other hormones connected to hunger. Studies show this hormone tsunami increases appetite along with your desire for sugary and fatty foods.

Czerwony says these strategies can help you master your food cravings:

Czerwony also emphasizes that its OK to ask for help when youre feeling stuck. Talk with your primary care physician or a registered dietitian. Thats what were here for: to educate and empower you to make better decisions. We can help you choose healthier options and modifications rather than focusing on things you have to cut.

When you make an effort to understand what flavors you do and dont like, its easier to find healthier alternatives. Czerwony offers a few ideas to get you started:

Try changing up the style of food instead of the food itself.

Figure out a great switch to keep you going.

Resisting food cravings is important if youre trying to lose weight or reduce blood pressure or cholesterol. But there is such a thing as being too restrictive. If youre relatively healthy, at a healthy weight, and your blood pressure and blood sugar are on point, feel free to indulge if you plan for it, Czerwony says.

Many of my patients eat around their craving. When they want something chocolatey, they eat a piece of fruit that doesnt hit the spot. Then they go for an ice pop with the same result and it goes on, Czerwony says.

Just eat what youre craving, really enjoy it and be done with it, she suggests. That way, youll be satisfied and wont need to go back for more.

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Heres the Deal With Your Junk Food Cravings - Health Essentials from Cleveland Clinic