Archive for the ‘Hormone Physician’ Category
Not going the Milky Way – The New Indian Express
Express News Service
HYDERABAD: Milk. The white nutritious liquid without which babies cant survive. Even several adults love to have a healthy milk and cereals breakfast, and festivals in India are incomplete without milk and desserts prepared from it. Until recently a lot of young adults included milk and milk products in their diet till they got to know through their dermatologists or dieticians that they need to exclude it from their diet given many had lactose intolerance.
What many of them especially women didnt know is that the contents in the milk can aggravate their acne giving them a major beauty worry which doesnt have instant fixes especially when theres a Big Day coming. Says Akansha Dhawal, 26, an aspiring model and a student at a fashion institute in the city, Its really annoying when on the day of a major shoot I wake up with pimples.
Though they can be hidden with make-up but it plays up in your mind and later you dread the marks. I have acne vulgaris and am still on medication. But ever since my dermatologist advised me to be completely off milk, they have substantially reduced. A knowledge report from Godrej Jersey done in August, 2019 says that only 16 per cent of adults in Hyderabad consume milk and acne can be one of the reasons why. Other reasons are of course, adulteration, and bad quality.
So is it just drinking milk that one has to stop or is it a total ban on milk related products like cheese, yogurt, fresh cream, ice cream, kheer etc? Says Dr. Syed Shazia Fatima, consultant cosmetic physician who practises at Livlife Hospitals, Jubilee Hills, There are ample studies which conclude that milk triggers acne severity. Now, though, there is no definite conclusion at the moment about milk being a direct trigger, it can progressively worsen acne in a lot of individuals, especially women with adult acne.
But how? Adds Dr Shazia, This could also be attributed to the fact, that milk contains hormones. These hormones can be both, the naturally occurring androgens in milk, or growth factors which are injected by farmers to enunciate faster maturation and milk production. Either can wreck havoc on the skin when interacting with ones natural hormones and worse for people with an ongoing hormonal imbalance.
The interesting part is that a lot of people consider milk harmful for acne because of the fat content. It is widely known that processed food, refined sugar and fatty foods, both trigger and worsen acne. Dr. Shazia further adds, But coming to dairy, skimmed milk or low fat milk was found to have a more profound effect than full fat milk.The major culprits being cheese, cottage cheese and milk.Ghee can be a potential aggravator too which is commonly ignored in Indian households.
A lot of doctors and I personally recommend going dairy free if you are someone dealing with persistent acne issues, while everything else has been evaluated and ruled out. Geetha Raman, 23, a research scholar at Osmania University was asked by her dermatologist to reduce the intake of milk so she was adding it just to her daily cup of tea but despite that precaution her acne turned inflammatory and red.
I completely gave up drinking milk and eating cheese, butter, yogurt and ice cream; now my skin is much better, she shares. To this adds Dr. AK Sirkar an independent dermatologist, Acne is known to get aggravated because of milk. But it aggravates more when certain drugs prescribed react with it thus causing more trouble. So can the young women say goodbye to milk and its health benefits? Sigh! Looks like. I can take supplements but cant afford to ruin my skin, sign off Akansha and Geetha.
NOT FOR ADULTSCows produce milk to feed their baby calves and help them grow. Whey and casein, the proteins in milk, stimulate growth and hormones in calves and in us when we drink their milk. When humans digest these proteins, they release a hormone similar to insulin, called IGF-1. This hormone is known to trigger breakouts. Sometimes the hormones in milk can also interact with our own hormones, confusing our bodys endocrine system and signaling breakouts.
NO TO LACTOSELactose is the natural sugar present in milk. After infancy, it becomes more difficult for humans to break lactose down and digest it. And if you belong to the 65 per cent of people who are lactose intolerant, your acne-related breakout could be due to a lactose sensitivity or allergic reaction.Source: https://www.healthline.com/health/dairy-and-acne#how-dairy-affects-skin
ACNE TRIGGERSMilk and dairy products cause an insulin spike in humans that cause the liver to produce even more IGF-1, leading to even more acne.Dairy causes your skin to produce excess sebum (oil), leading to you guessed it! more clogged pores, more acne, and a breeding ground for P. acnes bacteria, which feed on your sebum and spew out inflammatory by-products.Dairy glues together dead skin cells inside your pores, so they cant exit naturally, leading to clogged pores (and thus more acne).Source: https://www.clearskinforever.net/milk-acne-does-milk-cause-acne/
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Not going the Milky Way - The New Indian Express
Postmenopausal Hormone Therapy Market to Garner Brimming Revenues by 2024 – Statsflash
Post menopause is the period occurred after menopause followed by various syndromes like vaginal dryness, hot flashes, etc. During this period level of estrogen and progestin falls significantly leading to even serious complications like osteoporosis. The worldwide market for Postmenopausal Hormone Therapy is gaining moment substantially. This rising demand for Postmenopausal Hormone Therapy is due to increasing level of awareness about menopausal symptoms and its treatment. Another factor is growing population of post-menopausal women. Postmenopausal Hormone Therapy includes replenishment of body level of estrogen and progestin hormones in women through external intake of hormones. Thus, it help in treating the menopausal symptoms. It decreases the symptoms like vaginal dryness, hot flashes, disturbed sleep, night sweats and etc. The Postmenopausal Hormone Therapy helps in prevention of osteoporosis and hot flashes caused due to depletion of estrogen and progestin level in body. The Postmenopausal Hormone Therapy comprises of natural as well as synthetic estrogens. In order to enhance the menopausal treatment, it is also given in combination with progesterone.
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The treatment for post menopausal syndrome is generally treated with sequential or continuous schedules through various doses of estrogen, progestin or combination of both. Despite of existing controversy and confusion about the safety profile of the postmenopausal hormone therapy, the market for the postmenopausal hormone therapy has recorded positive inclining growth due to growing demand. The development of postmenopausal hormone therapy with respect to driving demand leads to introduction of highly safe treatment options to patients which include development of novel drug delivery system like vaginal estrogen drugs and transdermal estrogen patches. Low dose postmenopausal hormone therapy are used in order to address the backdrop caused due to safety issues. The non-hormonal treatment has comparatively least efficacy to produce optimum results, hence the postmenopausal hormone therapy market is observed to grow significantly.
However, the major retarding factors to the market include the affordability to the therapy. The cost for postmenopausal hormone therapy approximately revolves around US$ 10,000 per annum, and thus incurring a major burden on the patients pocket. Thus the population from developing and under developed countries faces a challenge of affordability for the postmenopausal hormone therapy. The post treatment risk of cervical cancer and coronary disease are another restraining factors for the market. Approved recognition of the products related to postmenopausal hormone therapy in compounding pharmacies particularly from developed countries is another deterring factor. However the opportunity for the market is the introduction of the product targeting the cardiovascular disease prevention.
The Postmenopausal Hormone Therapy market can be segmented by product, by therapy, by dosage form, by route of administration, by end-user and by geography. In the terms of product, the postmenopausal hormone therapy is classified into patches, tablets, creams, suppositories, and injections. The tablet formulation comprises the largest market share of the total postmenopausal hormone therapy market. However, due to growing concern of safety and long-term therapy the market for the patches are growing at much faster compound annual growth rate. Based on the therapy, the market is segmented into individual progestin, estrogen and combination therapies. The majority of market is occupied by estrogen therapy across the world.
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Based on the route of administration, the postmenopausal hormone therapy market is classified into oral, topical and subcutaneous implants. Due to high safety, oral administration has been the preferred choice of option for the patient. However, introduction of novel drug delivery system has driven the market for topical and subcutaneous products as well. In the terms of end-user, the target population are the women suffering from menopause. However, the treatment is influenced by the physician/ gynecologist, the target end-users are hospitals and specialty clinics.
Geographically, North America occupies the largest market share followed by other developed region like Europe. The United States accounts for a major share of the global market. The high awareness level and high purchasing power in this region led the market of postmenopausal hormone therapy for expansion significantly. However, the same factor of affordability has restrained the markets in developing regions. Despite of this, Asia Pacific has shown striking increase in its growth rate for the postmenopausal hormone therapy market. Rising population, increase in disposable income, and increase in awareness level are some key factors driving the Asia Pacific Market. Due to this factors, the Asian market is observing high number of new entrants compared to those in developed regions.
The Major players reported in the market include Abbott Laboratories, AbbVie, Inc., Bayer Pharma AG, Hisamitsu Pharmaceutical Co., Inc., Novartis AG, Novo Nordisk A/S, Orion Pharma AB, Pfizer, Inc., Meda pharmaceuticals, Teva Pharmaceutical Industries Ltd. and TherapeuticsMD, Inc., etc
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Postmenopausal Hormone Therapy Market to Garner Brimming Revenues by 2024 - Statsflash
Sleep 101: The importance of getting a good nights rest – The News Minute
While getting 6 to 8 hours of sleep is recommended by experts, some people may not necessarily need the same amount of sleep as others.
When you wake up after a good nights rest, it makes you feel alert, fresh and well-rested. In contrast, lack of a good nights sleep may leave you feeling grouchy, moody and irritable. Of course there are the peculiar individuals who get seven hours of sleep but still feel tired and others who seem to hardly sleep, but have so much energy. Getting a good amount of sleep is crucial to leading a healthy life. However with so many people having conflicting sleeping habits and patterns, what really makes for good sleep and what can you be doing to make sure that you are getting enough of your beauty sleep? As always science has the answers which TNM has sought out.
On average, an individual sleeps for a total of around 26 years in their entire lifetime, which amounts to over 200,000 hours of sleep. However, there are incredible discrepancies with the amount of sleep required from person to person. It is recommended that teens and young adults get between 6 and 7 hours of sleep, while older adults are advised to get at least 7 to 8 hours of sleep. In elderly individuals and newborn babies, more than 8 hours of sleep is recommended by experts.
Despite these guidelines, why are some individuals able to get better quality of sleep than others? Why do our individual sleep habits vary? As TNM found out, there are multiple factors which contribute to how much sleep is needed for each person.
While age and environmental factors definitely contribute to the amount of sleep an individual may need, practically speaking what we need to account for is the individuals sleep debt, explains Dr Samith Shetty, a physician from Bengalurus Sparsh Hospital.
Sleep debt is a term used by experts to explain the compounded effects of not getting enough sleep.
To put it simply, it is as though the body keeps track of every extra hour that you should be sleeping but instead are spending awake. These hours accumulate over a period of time and do take a toll on your health, adds the doctor. Lack of adequate sleep can take a serious toll on ones health.
What happens to the body when you dont get enough sleep?
Chronic sleep deprivation may put people at risk of developing significant health risks including heart disease, diabetes, obesity, early mortality. A report was recently published in the Journal of Experimental Psychology based on a study done at the Michigan State Universitys Sleep and Learning Lab which revealed that a chronic lack of sleep is more harmful than earlier thought.
Our research showed that sleep deprivation doubles the odds of making errors and triples the chances of lapsed attention, stated Kimberley M Fenn one of the researchers of the study to the media.
Another researcher noted that the latest findings proved the popular belief that only cognitive abilities were affected by sleep deprivation was wrong.
In contrast, getting adequate rest and sleep keeps people alert and active. It also aids in various metabolic processes. Research has also shown that sticking to an established routine for sleep aids in learning, comprehension and memory.
Breaking down the science behind sleep
There is not one mechanism which is at play to ensure that a person sleeps. Sleep occurs as a combination of biological factors and environmental ones. There exists a natural system in all of us called the circadian rhythm which is an internal clock of sorts that maintains the sleep-wake cycle.
A part of the brain called the hypothalamus interprets signals from the external environment (such as sunlight) and relays this to another part of the brain which tells the body what hormones and chemicals to suppress or release depending on the time of day.
During the day time, the eyes perceiving light will be interpreted in this manner by the hypothalamus to relay to the body that it is time to be awake. Whereas at night time, lack of light in the environment contributes to the secretion of a hormone called melatonin, which allows you to sleep. Melatonin remains in the bloodstream for about 9 to 12 hours, following which melatonin levels begin to decrease. There is almost no melatonin traceable in the bloodstream during the daytime.
Infants and young children require more sleep than adolescents. Elderly individuals also require more sleep than the average adult.
There are certain steps you can take to ensure that you are getting adequate sleep.
First, it is crucial to set a bedtime. This will help you get into the habit of ensuring that you go to sleep and wake up at a regular time daily. By doing so, it will help maintain your natural circadian rhythm without disturbing it too much. Get off electronic devices at least 30 minutes before getting to bed. Ensure that you are sleeping on a comfortable mattress that supports your back. Turn off lights, this will help ensure that melatonin is released appropriately. Some people might want certain sounds, scents or maybe a night light, which is ok as long as it is keeping them comfortable, says the doctor.
He also advises that people avoid smoking or drinking prior to sleeping as it may have negative consequences on the brain.
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Sleep 101: The importance of getting a good nights rest - The News Minute
The common health problems behind dry, thinning and shedding hair – Herald Publicist
A number one hair knowledgeable has revealed how widespread hair and scalp issues suffered by girls might be linked to well being points likedehydration and a hormonal imbalance.
Trichologist Simone Lee, from Perth, stated hairloss might be triggered by sudden hormonal modifications, whereas an irritated scalp is an indication of extended dehydration and a poor food plan.
Ms Lee advised Each day Mail Australia the power and vitality of hair is immediately linked to general well being, and revealed the key to rising a lustrous mane all comes all the way down to food plan.
Widespread hair complaints like thinning, shedding and dry, flaky scalps might be traced again to basic well being points from dehydration to poor diet
DRY SCALP
Dry, irritated scalps develop when the pores and skin is disadvantaged of moisture over a chronic time period.
Ms Lee stated a wide range of components contribute to dehydration of the scalp, together with extreme publicity to chilly air or air-con, repeated use of heated styling instruments which strip moisture from the pores and skin, low consumption of water and poor diet.
Applicable consumption of water is crucial for all times two thirds of our pores and skin tissues are made up of water, she stated.
The human physique loses roughly two litres of physique fluids every day, which is changed via consumption of water and different liquids.
Ingesting at the very least two litres of water on daily basis will hydrate each your hair and scalp, stopping flakiness and irritation.
Zinc deficiency also can trigger dry, irritated pores and skin, so enhance your consumption of zinc-rich meals like shellfish, legumes, fruit and nuts.
Medical situations like dermatitis, eczema, dandruff and hormone imbalances also can contribute to a dry, dehydrated scalp and ought to be handled in session with a certified physician or dermatologist.
Australian trichologist Simone Lee (pictured) stated the key to rising wholesome hair begins together with your food plan
THINNING ANDHAIR LOSS
The commonest reason behind hair loss in girls is Androgenic Alopecia, extra generally often called feminine sample hair thinning.
Genetics is without doubt one of the main causes of feminine Alopecia, with thinning normally beginning on the crown of the top, leaving the hairline unaffected.
However hormonal imbalances are one other widespread reason behind hair loss for girls.
Overproduction of the intercourse hormone dihydrotestosterone often called DHT causes hair follicles on the scalp to shrink, which ends up in thinner strands and infrequently everlasting hair loss.
Fortunately, hormonally triggered Androgenic Alopecia might be handled with prescription medicine and hormone balancing lotions, which cut back the quantity of DHT that reaches follicles and causes thinning.
Proteins
Hair is comprised of the protein keratin, so a food plan missing in protein will finally result in hair loss.
There are 4 key amino acids needed to provide hair keratin cysteine, lysine, arginine and methionine.
Up your consumption of proteinby consuming lean meats like hen, fish, beef, pork or lamb, or dairy merchandise together with eggs, milk, cheese and yoghurt.
Carbohydrates
Carbohydrates are important for a balanced food plan, regulating protein and fats metabolism which is crucial for wholesome hair progress.
Easy carbs might be present in unprocessed wholefoods together with fruit, honey, milk, beans, lentils and peas.
Fat
Wholesome fat assist the physique to soak up nutritional vitamins and minerals, whereas polyunsaturated fat assist to maintain hair lustrous and glossy.
Good fat, wealthy in Omega three, are present in fish like salmon, tuna and sardines, in addition to avocado and linseed oil.
Nutritional vitamins
Water soluble nutritional vitamins like Vitamin A, B (thiamine), C, D, E and Ok are important to keep up wholesome hair and a hydrated scalp.
Contemporary fruit, inexperienced greens and entire grains are good sources of water soluble nutritional vitamins.
Minerals
Minerals together with cobalt, copper, iodine, iron and zinc are all linked to robust, wholesome hair.
Cobalt is present in broccoli, copper in cereals and nuts, iodine in shellfish and iron in liver and egg yolks.
Zinc, which is immediately linked to hair loss and dry scalps, is present in oysters, wheatgerm and bran.
Water
Ingesting at the very least two litres of water on daily basis will hydrate pores and skin and nourish hair, stopping thinning, shedding and dry scalps.
Supply: Simone Lee
Water soluble nutritional vitamins like Vitamin A, B (thiamine), C, D, E and Ok are important to keep up wholesome hair and a hydrated scalp
As a result of hair is comprised of the protein keratin, a food plan missing in protein and related amino acids also can set off hair loss.
There are 4 key amino acids needed to provide hair keratin cysteine, lysine, arginine and methionine.
Of those amino acids lysine and methionine are categorised as important, that means they dont seem to be fashioned by the physique and should be made accessible via our diets, Ms Lee stated.
She really helpful boosting your consumption of protein by consuming lean meats like hen, fish, beef, pork or lamb, or dairy merchandise together with eggs, milk, cheese and yoghurt.
SHEDDING
The typical hair progress cycle lasts from three to 5 years, with hair rising round half an inch every month.
However well being situations and intense medical remedies, like chemotherapy, may cause main disruptions to this course of, resulting in extreme shedding and short-term hair loss.
Sudden shedding scientifically often called Telogen Effluvium, a type of short-term hair loss is normally attributable to stress or traumatic experiences.
Dramatic weight reduction or a fast, uncommon shift in food plan also can trigger hair to shed, as can medicine, abroad journey and overexposure to ultraviolet mild.
Rising your consumption of iron after a sudden shock or trauma may help regulate the hair progress cycle and strengthen brittle hair.
Iron-rich meals embrace purple meat, darkish inexperienced greens like spinach and kale, lentils, fish and darkish chocolate.
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The common health problems behind dry, thinning and shedding hair - Herald Publicist
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November 19, 2019 Cover
Pam Tillis keeps busy touring, making appearances and forever moving forward to her next musical project. Just last week she was a presenter for the Country Music Association awards with Women of Country Music as the theme.Country music is lucky to have her in their genre. But it wouldnt have mattered what Tillis chose to record and perform, she has one of those rare voices that lends itself to anything she wants to sing. She can easily move from classic country, to pop, to a bluesy torch singer wherever her heart, her soul and the lyrics lead.
Its rare when the puzzle pieces just seem to fit the first time a person opens the jigsaw box, but when Norm Stulz had the ability to make people laugh as early as the second grade in Detroit, there was no denying opening the comedy box was his lifes calling.Just a few years later in the seventh grade, he met the girl of his dreams and to this day, he and his wife Sharon, continue to build on a life together as two crazy kids in love. Laughter has been the glue for the relationship and the career path that has sustained Stulz for nearly 40 years.
Hosting a holiday dinner for your family is an undertaking in itself, but resorts are tasked with preparing the perfect menu for thousands of guests at multiple restaurants.Which items do guests want on the menu? How much food to order? When to start cooking? How many guests to prepare for? These are all questions the food and beverage departments must consider when planning for a holiday.
This time of year box stores are filled to the brim with every electronic device and latest phone known to man, but are there people on your list who already have all that stuff? Everyone has that one relative who is a challenge when comes to finding the perfect gift. Unique people require unique items and thinking outside the traditional box store offerings. Maybe that difficult-to-buy-for person is yourself because you never know what might strike your fancy.
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November 19, 2019 Cover
Pam Tillis keeps busy touring, making appearances and forever moving forward to her next musical project. Just last week she was a presenter for the Country Music Association awards with Women of Country Music as the theme.Country music is lucky to have her in their genre. But it wouldnt have mattered what Tillis chose to record and perform, she has one of those rare voices that lends itself to anything she wants to sing. She can easily move from classic country, to pop, to a bluesy torch singer wherever her heart, her soul and the lyrics lead.
Its rare when the puzzle pieces just seem to fit the first time a person opens the jigsaw box, but when Norm Stulz had the ability to make people laugh as early as the second grade in Detroit, there was no denying opening the comedy box was his lifes calling.Just a few years later in the seventh grade, he met the girl of his dreams and to this day, he and his wife Sharon, continue to build on a life together as two crazy kids in love. Laughter has been the glue for the relationship and the career path that has sustained Stulz for nearly 40 years.
Hosting a holiday dinner for your family is an undertaking in itself, but resorts are tasked with preparing the perfect menu for thousands of guests at multiple restaurants.Which items do guests want on the menu? How much food to order? When to start cooking? How many guests to prepare for? These are all questions the food and beverage departments must consider when planning for a holiday.
This time of year box stores are filled to the brim with every electronic device and latest phone known to man, but are there people on your list who already have all that stuff? Everyone has that one relative who is a challenge when comes to finding the perfect gift. Unique people require unique items and thinking outside the traditional box store offerings. Maybe that difficult-to-buy-for person is yourself because you never know what might strike your fancy.
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MEDICAL MATTERS: Two Balls and Two Strikes – Odessa American
Sorry this isnt your typical sports story with a line score, but now that I have your attention, I have some important information to share with you. Its Movember, and besides shaggy facial hair, it brings awareness and support for testicular cancer, prostate cancer and suicide.
So, if its Mens Health Awareness, you may be asking yourself, why is a female writing this article? Well, women have been saving men for centuries now. As a physician, I can tell you if it wasnt for wives and girlfriends, I wouldnt have any male patients. Im sure that a couple hundred years ago a pilgrim wife told her pilgrim husband, Thou hast a most foul spot on thy back! Get thee to the physician! In all seriousness though, men are 24 percent less likely to have seen a physician within the last year.
The average life expectancy in the U.S. of men is 76.2 years, while for women it is 81 years. Approximately 12 percent of men over the age of 18 are in poor health. So, why is that? There are multiple factors, but there is a reluctance of men to admit they have a problem and need help, whether that is from an injury to mental health. We live in a society where men are expected to suck it up and not discuss any chinks in their armor. Admitting they have a problem is perceived as weakness. Im not attacking masculinity, but not seeking routine health care is a detriment to both physical and mental health, and ultimately overall survival. So, how do we change that? As G.I. Joe always said, Knowing is half the battle.
Testicular cancer is the most commonly diagnosed cancer in young men. It can occur at any age, but it is more frequent from age 20 to 45. The average age of diagnosis in the U.S. is 33 years old. About 1 in every 250 men will be diagnosed with testicular cancer during their lifetime. Fortunately, there is a 95 percent five-year survival rate, even at advanced stages. As with all cancers, the earlier the diagnosis, the better the survival. Approximately 9,500 men will be diagnosed every year with around 400 deaths.
Risk factors for testicular cancer include family history (especially in a brother), history of undescended testicle (even surgically corrected), personal history of testicular cancer and white males. HIV infection also carries an increased risk of developing testicular cancer. Testicular cancer is rare in black men, but they are more likely to die from it if it develops. Treatment is mainly surgical removal of the affected testicle, but it may include chemotherapy and radiation depending on stage.
Having a single orchiectomy does not affect a mans ability to have sex or conceive children. The main tool against testicular cancer is early diagnosis and treatment. Men should perform routine self-testicular exams, beginning in their teens and continuing throughout their life.
The best time to perform a testicular exam is either in the shower or just after getting out of the shower. The technique is simple: grasp each testicle between the thumb and fingers and gently roll it. You are looking for anything out of the ordinary for you: change in size or shape, a lump or tenderness. If you find anything, make an appointment with your doctor to get it checked out ASAP.
Prostate cancer is the second most common cause of cancer death in men (lung cancer is number one for both men and women). Approximately 1 in 9 men will be diagnosed with prostate cancer in their lifetime. The incidence of prostate cancer goes up with age, with the average age of diagnosis being 66.
Though there is a 98 percent five-year survival rate if discovered early, 88 men die of prostate cancer every day. There are approximately 175,000 new cases every year with over 30,000 deaths. Risk factors for prostate cancer include family history, obesity, diet high in saturated fats and high testosterone levels (including testosterone replacement therapy). Black men have a 74 percent higher rate of prostate cancer than other races and the death rate is twice as high.
There is a link to the BRCA and HER2 genes causing prostate cancer and men with that history should begin screening at age 40. For most men, we recommend beginning screening at age 50 with a PSA (prostate-specific antigen) level. The PSA has faced a lot of controversy recently, but it is still a good test for screening for prostate cancer.
The trend of the PSA is more important because the PSA typically doubles when prostate cancer is present. We recommend men with a family history of prostate cancer and black men begin screening at age 45. Signs and symptoms of prostate cancer are often the same as symptoms of enlargement of the prostate (BPH, or benign prostatic hypertrophy).
These symptoms include increased frequency of urination at night (nocturia), decreased force of the urine stream, pain with urination, having to strain to begin the stream, erectile dysfunction, painful ejaculation, blood in the urine or sperm and pain/stiffness in your lower back, hips or upper thighs. Treatment options vary from surgery (prostatectomy) to chemotherapy, radiation, hormone therapy and even just surveillance.
Suicide is the 10th leading cause of death in the U.S. and 11th in Texas. Texas ranks 40th in the nation in suicide rate per 100,000 people. Unfortunately, its not that we have less suicides but more people. There were about 1.4 million suicide attempts in the U.S. in 2017 and 47,000 deaths (almost 3,800 in Texas). Men are three and a half more likely to die from suicide than women, though women attempt suicide more often.
The main reason for this difference is men choose more deadly methods of suicide, mainly firearms. There are 129 suicides per day, and in Texas one person dies every two hours from suicide. White males account for almost 70 percent of suicide deaths, with middle-aged white men (45-54) having the highest rate. Men account for 75 of suicides in the U.S. Worldwide, a man dies every minute by suicide.
The VA released a report in September that 17 veterans die every day from suicide. This does not include active duty suicides, reservists or service members who did not have overseas duty (which explains the reduction from the oft quoted 22/day numbers). Its still too high, no matter how you cook the numbers.
In conclusion, find yourself a good doctor that you trust and see them regularly. Dont be afraid to speak up and seek help when something is wrong. Stay in contact with your friends and family members and talk with them. Know the facts and be aware of your own body. We women want you guys around for the long hauleven if you do hog the remote control.
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MEDICAL MATTERS: Two Balls and Two Strikes - Odessa American
Tips for making the holiday meal that is higher on the flavor, lighter on the calories – KENS5.com
SAN ANTONIO San Antonio is gearing up for food coma season, which often results in feasting ourselves silly over the holidays. However, one San Antonio doctor says if you shop smart it's possible to make holiday meals that are equal parts delicious and healthy.
Cynthia Cantu is a primary care physician at UT Health San Antonio. The majority of her patients are adults living with diabetes, high blood pressure or coronary artery disease. She says their nutrition is a big factor in keeping them out of the hospital.
A doctor-approved shopping list can be beneficial to anyone with an appetite for holiday favorites.
For the main dish, Cantu recommends sticking to turkey. Start with a hormone-free bird. Check the label for salt and seasoning additives and refrain from adding additional spices from your cabinet.
People don't realize (the turkey) already has sodium, so that hurts you a lot. So please pay attention to those things," she said. "(Use) a little bit of low-fat butter and don't fry it. Just (bake) in the oven and you're good to go.
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Heading to the produce section, Cantu recommends serving fresh sides.
You can make a cauliflower mash and it will taste delicious. You really cannot tell the difference. You just need one (head of cauliflower) and it makes a good quantity. You just add a little bit of butter and cheese and that's a very good substitution,she said.
Green beans are another go-to menu item. But instead of canned soup, opt for turkey bacon and glazed pecans.
To satisfy your sweet tooth, make a cheesecake with evaporated milk or cookies with almond flower and Stevia.
To keep your healthy shopping trip within budget, seek out the store brand.
You can use the Walmart brand. If you look at the back it's the same thing, Cantu said.
If you need help planning that flavorful meal for your family without all the calories, Cantu recommends searching online for low-carb and low-sodium recipes.
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Tips for making the holiday meal that is higher on the flavor, lighter on the calories - KENS5.com
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November 19, 2019 Cover
Pam Tillis keeps busy touring, making appearances and forever moving forward to her next musical project. Just last week she was a presenter for the Country Music Association awards with Women of Country Music as the theme.Country music is lucky to have her in their genre. But it wouldnt have mattered what Tillis chose to record and perform, she has one of those rare voices that lends itself to anything she wants to sing. She can easily move from classic country, to pop, to a bluesy torch singer wherever her heart, her soul and the lyrics lead.
Its rare when the puzzle pieces just seem to fit the first time a person opens the jigsaw box, but when Norm Stulz had the ability to make people laugh as early as the second grade in Detroit, there was no denying opening the comedy box was his lifes calling.Just a few years later in the seventh grade, he met the girl of his dreams and to this day, he and his wife Sharon, continue to build on a life together as two crazy kids in love. Laughter has been the glue for the relationship and the career path that has sustained Stulz for nearly 40 years.
Hosting a holiday dinner for your family is an undertaking in itself, but resorts are tasked with preparing the perfect menu for thousands of guests at multiple restaurants.Which items do guests want on the menu? How much food to order? When to start cooking? How many guests to prepare for? These are all questions the food and beverage departments must consider when planning for a holiday.
This time of year box stores are filled to the brim with every electronic device and latest phone known to man, but are there people on your list who already have all that stuff? Everyone has that one relative who is a challenge when comes to finding the perfect gift. Unique people require unique items and thinking outside the traditional box store offerings. Maybe that difficult-to-buy-for person is yourself because you never know what might strike your fancy.
See the original post:
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It’s a Great Day to Thrive – Curetoday.com
New therapies approved following innovative research are increasing survival rates for patients with advanced lung cancer.
BY Mike Hennessy, Sr.
In the face of cancer, she chose to understand the biology of her disease and how it influenced her treatment options, eventually leading her to a clinical trial.
Warmerdam is not alone when it comes to outliving the disease she thought would claim her life, like it did her fathers. New thera- pies approved following innovative research are increasing survival rates for patients with advanced lung cancer.
In one of our feature stories, we hear from longtime lung cancer thrivers. Youll read more about Warmerdam and two other survivors; one is 15 years past diagnosis; the other, seven. Although these individ- uals endured lots of treatment, side effects and struggles along the way, firsthand accounts from them and others continue to inspire and offer hope to other patients and survivors, as well as researchers and health care providers who daily strive to eradicate cancer.
Also inside, CURE takes a deeper look at the latest therapies for treating patients whose non-small cell lung cancer (NSCLC) has spread to the brain, also known as brain metastases. The cover story examines the role of surgery and radiation, as well as how tumor mutation may affect individual treatment plans. Experts weigh in on how they approach patients with this type of disease.
And for years, the treatment of small cell lung cancer remained stagnant, mainly because of a lack of clinical trials in this disease state. But in recent years, researchers have begun looking into newer techniques that are proving successful in early clinical trials. These trials investigated PARP inhibitors, which are often used in gynecologic cancers, and a combination of immunotherapy with chemotherapy. Earlier this year, the results of one study led to the Food and Drug Administration approval of Tecentriq (atezolizumab) in the first-line setting. The results have many excited about the future, but for now, the standard of care remains the same.
This issue also covers a recent drug approval for metastatic NSCLC, the disparities that exist in the care of people with the disease and as described by a patient the silver linings of having cancer.
As always, thank you for reading.
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It's a Great Day to Thrive - Curetoday.com
Living with Lung Cancer: The Silver Linings – Curetoday.com
How a cancer diagnosis leaves one woman feeling humbled.
I know this question makes a lot of people angry. I used to get angry whenasked that is, until I came to realize that its not the askers fault. I would have asked the same thing before I actually got lung cancer. Society often teaches us that the only way you can get lung cancer is from smoking. This isnt true. There are so many contributing factors that people are unaware of, such as radon, air pollution, genetics and just good old-fashioned bad luck.
But in any case, no one deserves lung cancer. Most of us have bad habits, but Ive seen some of the healthiest people I know acquire lung cancer and pass away from it. This month marks seven years that Ive been living with it. I received my diagnosis less than a month after my 33rd birthday, during lung cancer awareness month. I wasnt even aware it had its own month.
In the beginning, I had no hope and no faith. I felt helpless. I no longer had control over my body. I was told I had 12 to 18 months to live. Being the single mom of a 7-year-old little girl didnt help with my depression. I quickly got on antidepressants. There is no shame in that; I had to be strong for my girl.
Its now been seven years since that fateful day when I learned my life would never be the same. Ive come a long way in personal growth and have learned that sometimes the best of Gods blessings can come from the worst of circumstances.
First, my appreciation for life was renewed. I had a second chance, and I could choose to be a better person. Before cancer, I was a workaholic. I never stopped to smell the roses, walk the beach at sunset, watch my daughter and her friends just be kids, and teach her so much by being able to be home with her. All the smells, the sounds, the beauty of this life I now appreciated.
Since the diagnosis, my child has become very empathetic of others, an advocate for lung cancer, and gave her life to Christ at the age of 8. We didnt push her; the faith just bloomed. I love her more than anything in this world, and I couldnt be more proud of the 14-year-old freshman she is now.
Ive also made some incredible friends from all over the world through the lung cancer community. We are united in a hunger and new appreciation for a life that most take for granted. Yes, Ive lost many of those friends. And yes, it hurts whenI do, but thats how I know I truly loved them and will see them again one day. No one can be replaced when they are a part of your heart.
Let me just say that getting lung cancer at such a young age was a humbling experience. I was so self-centered and uncaring before. I was cutthroat at myjob. Im happy to say Im not that way anymore. I once was blind, but now I see.
I see that we have this one life, one chance to make a difference in others and maybe make this world a better place. Evil didnt win. Cancer hasnt won and will never win because I already have. I wouldnt take it back for a second. This is my life and this is my purpose helping others.
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Living with Lung Cancer: The Silver Linings - Curetoday.com
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November 19, 2019 Cover
Pam Tillis keeps busy touring, making appearances and forever moving forward to her next musical project. Just last week she was a presenter for the Country Music Association awards with Women of Country Music as the theme.Country music is lucky to have her in their genre. But it wouldnt have mattered what Tillis chose to record and perform, she has one of those rare voices that lends itself to anything she wants to sing. She can easily move from classic country, to pop, to a bluesy torch singer wherever her heart, her soul and the lyrics lead.
Its rare when the puzzle pieces just seem to fit the first time a person opens the jigsaw box, but when Norm Stulz had the ability to make people laugh as early as the second grade in Detroit, there was no denying opening the comedy box was his lifes calling.Just a few years later in the seventh grade, he met the girl of his dreams and to this day, he and his wife Sharon, continue to build on a life together as two crazy kids in love. Laughter has been the glue for the relationship and the career path that has sustained Stulz for nearly 40 years.
Hosting a holiday dinner for your family is an undertaking in itself, but resorts are tasked with preparing the perfect menu for thousands of guests at multiple restaurants.Which items do guests want on the menu? How much food to order? When to start cooking? How many guests to prepare for? These are all questions the food and beverage departments must consider when planning for a holiday.
This time of year box stores are filled to the brim with every electronic device and latest phone known to man, but are there people on your list who already have all that stuff? Everyone has that one relative who is a challenge when comes to finding the perfect gift. Unique people require unique items and thinking outside the traditional box store offerings. Maybe that difficult-to-buy-for person is yourself because you never know what might strike your fancy.
Read this article:
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November 19, 2019 Cover
Pam Tillis keeps busy touring, making appearances and forever moving forward to her next musical project. Just last week she was a presenter for the Country Music Association awards with Women of Country Music as the theme.Country music is lucky to have her in their genre. But it wouldnt have mattered what Tillis chose to record and perform, she has one of those rare voices that lends itself to anything she wants to sing. She can easily move from classic country, to pop, to a bluesy torch singer wherever her heart, her soul and the lyrics lead.
Its rare when the puzzle pieces just seem to fit the first time a person opens the jigsaw box, but when Norm Stulz had the ability to make people laugh as early as the second grade in Detroit, there was no denying opening the comedy box was his lifes calling.Just a few years later in the seventh grade, he met the girl of his dreams and to this day, he and his wife Sharon, continue to build on a life together as two crazy kids in love. Laughter has been the glue for the relationship and the career path that has sustained Stulz for nearly 40 years.
Hosting a holiday dinner for your family is an undertaking in itself, but resorts are tasked with preparing the perfect menu for thousands of guests at multiple restaurants.Which items do guests want on the menu? How much food to order? When to start cooking? How many guests to prepare for? These are all questions the food and beverage departments must consider when planning for a holiday.
This time of year box stores are filled to the brim with every electronic device and latest phone known to man, but are there people on your list who already have all that stuff? Everyone has that one relative who is a challenge when comes to finding the perfect gift. Unique people require unique items and thinking outside the traditional box store offerings. Maybe that difficult-to-buy-for person is yourself because you never know what might strike your fancy.
Read more here:
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Brookwood Baptist Health Doctors: What to Know During Diabetes Awareness Month – Birmingham Times
By Ameera StewardFor the Birmingham Times
November is Diabetes Awareness Month, a time to raise understanding about diabetes, an illness that affects millions of Americans of all ages.
There are two types of diabetes: Type 1 and Type 2.
Type 1, once known as juvenile diabetes or insulin-dependent diabetes, is a chronic condition in which the pancreas, an organ located in the abdomen that plays an essential role in converting food into fuel for the body, produces little or no insulin, the hormone needed to allow sugar (glucose) to enter the bodys cells to produce energy.
Type 2 diabetes is a chronic condition that affects the way the body metabolizes glucose, an important source of fuel for the body. With Type 2, the body either resists the effects of insulin or doesnt produce enough of the hormone to maintain normal glucose levels.
The Birmingham Times recently sat down with two physicians from Brookwood Baptist Healthinternal medicine physician Erin Townsley, MD, and interventional cardiologist Hutton Brantley, MDto discuss and get advice about dealing with diabetes.
Family and Food
People with a family history of Type 2 diabetes are at an increased risk for developing the illness, Townsley said.
If you have a family history of diabetes and then have the environmental or lifestyle factors that also play a role, thats going to increase your risks, she said. Just because its in your genetics and just because you have a family history doesnt mean youre going to definitely get it; it just means youre at increased risk, compared with someone who doesnt have a family history and lives that same kind of lifestyle.
Townsley recommends that those who have diabetes avoid foods high in carbohydrates (sugars, starches, and fibers found in fruits, grains, vegetables, and milk products), such as bread and pasta, as well as limit daily intake of foods with added sugars and excess caloriesall of which increase the risks of obesity and diabetes. The other thing to watch is being sedentary or not exercising, which also can increase the risks for being obese and having diabetes.
There is no cure, per se, but I have seen diabetes essentially resolve with dramatic lifestyle changes [and] weight loss, Townsley explained. Now, that risk will always be there for [some] people, so that never goes away. But if you can change your lifestyle, lose weight, change your eating habits, and increase your physical activity, you can potentially come off diabetes medications [and] dramatically reduce your risk for developing complications [from the illness].
And there are several potential complications. According to the American Diabetes Association, diabetes can increase the risk for many serious health problems, including skin disorders and infections; eye and vision problems, such as glaucoma and cataracts; neuropathy, or nerve damage, particularly in the legs and feet; kidney disease and failure, which can result in the need for dialysis; hypertension, or high blood pressure; and stroke and heart disease.
Symptoms to Watch For
Symptoms associated with diabetes might include tiredness and increased hunger. If blood sugar is really high, it can cause a catabolic reaction (a process in which the body breaks down large molecules for energy) and lead to weight loss. Also, high blood sugar is almost like a diuretic (a substance that causes increased urination), so it can have a water-pill effect and make patients urinate frequently.
Townsley wants people to understand how important it is to recognize diabetes and get it treated early.
If you know you struggle with being overweight or obese and you have a strong family history of type 2 diabetes, even if you feel like youre young, you need to see a physician about it and get tested, she said. I think thats the biggest thingearly detection.
Sometimes patients with Type 2 diabetes dont necessarily feel bad or realize that they feel bad, Townsley added. Their blood sugar may be elevated, and they may be slowly developing problems from diabetes, but they dont feel it on a day-to-day basis.
Some patients have a hard time understanding the importance of treating [diabetes], so [some] constantly have elevated blood sugar and dont necessarily have a lot of symptoms, or at least symptoms they recognize. Diabetes is sort of a slow process, and patients may not really realize that theyre having issues from it, she said.
Complications may not happen tomorrow, next month, or even in three to five years, but they eventually will happen, and it can be 20 years from when [someone] is diagnosed. Its really sometimes hard for me to get patients to look at the long goal, so I spend a lot of time educating patients about the importance of [monitoring diabetes]. The bottom line is most people dont want to take a lot of medicines, especially when they get to the point of having to inject insulin, [which is] a really big hurdle for patients to get used to. Its a lifestyle change to have to do that every day.
Heart Disease
Brantley said diabetes is considered the highest risk factor development of one particular complication: heart disease higher than smoking or high blood pressure.
Diabetes with elevated blood glucose damages nerves and blood vessels, making people with diabetes vulnerable to the risk factors for cardiovascular disease: smoking, high blood pressure, abnormal cholesterol levels and triglycerides, he said. People with Type 1 and Type 2 [diabetes] are both at risk for early-onset heart disease.
The heart specialist added that maintaining a healthy weight is best for people with diabetes because being overweight tends to increase blood glucose, blood pressure, and blood fat levels.
Even a modest 10- to 20-pound weight loss can improve your levels, he said.
Additionally, regular physical activity is not only associated with better blood glucose levels but also can help reduce blood pressure.
Aim for at least 30 minutes of moderate-intensity aerobic exercise most days of the week and at least two strength-training sessions per week, he said.
Brantley also emphasized the importance of not smoking.
If you have diabetes, youre already at risk for heart and blood vessel problems. Nicotine only exacerbates the problem by damaging and tightening blood vessels, and raising blood pressure and blood glucose, he said.
I recommend that patients talk to their health-care provider and discuss specific risk factors for diabetic heart disease to come up with an individualized treatment plan, including further cardiac evaluation.
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New guideline, created with input from U of T researchers, calls for end to routine screening for thyroid disorders – News@UofT
Screening for thyroid dysfunction in patients without symptoms does not improve health and creates unnecessary expenses for the health-care system, according to a new guideline from the Canadian Task Force on Preventive Health Care.
Family doctors commonly order thyroid screening tests during routine patient visits. But the task force found no evidence of a benefit to patients in a systematic review of 22 studies on the effectiveness of treatment for abnormal thyroid stimulating hormone (TSH) levels in adults without symptoms. Moreover, harms of unnecessary testing include the need to take medication unnecessarily and have regular medical visits as well as follow-up blood tests to check TSH levels.
The message to family doctors: Stop routinely checking that box on blood test requisition forms for patients without symptoms or risk factors.
Family doctors thought they were helping the patient by hopefully identifying thyroid disorder early on and preventing negative health outcomes, saysDonna Reynolds, a member of the task force working group who is an assistant professor in the University of Torontos department offamily and community medicine and at theDalla Lana School of Public Health.
Now weve found that we werent necessarily helping the patient and were potentially causing harm not necessarily physical harms, but turning a person into a patient when they otherwise didnt have to be one.
The Canadian Medical Association Journal published the guideline this week.
Symptoms of thyroid disorder can be quite vague, so the relationship that doctors form with patients over time can give insight into whether certain symptoms are starting to look more like a pattern, says Reynolds, who is also a family physician at Scarborough Health Network.
The longer you practice, the more you start to see patients with similar complaints, and we put patients on a routine to make sure we dont miss anything, says Reynolds. I think thats good clinical care, but its also important to know if were over-treating and over-diagnosing people.
The Canadian Institute for Health Information and Choosing Wisely Canada have found that up to 30 per cent of medical tests, treatmentsand procedures in some areas of health care may be unnecessary.
Choosing Wisely Canada has introduced several measures to reduce over-testing, and a recent effort to limit thyroid tests proved successful in a U of Tstudy published last week. Associate ProfessorMichelle Greiver and other researchers in U of Ts department of family and community medicine led that work, which found a 13 per cent reduction in thyroid tests over two years among family health teams participating in the Choosing Wisely Canada effort. Thatscompared to a minor reduction among teams that did not participate.
The group estimated $1.5 million in yearly savings from the reduced number of thyroid tests.
Reynolds and other members of the task force emphasize that the new thyroid screening guideline is for adults with no symptoms or risk factors for thyroid dysfunction.
The guideline does not apply to pregnant women, those who have exhibited symptoms or have been diagnosed with thyroid dysfunction,those who have had thyroid surgery, those who are taking medications that can affect the thyroidor those undergoing radiotherapy that could affect the thyroid.
Its good to have a critical eye on what were doing and why were doing it, and to practise evidence-based medicine to ensure were doing the best for our patients, says Reynolds.
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New guideline, created with input from U of T researchers, calls for end to routine screening for thyroid disorders - News@UofT
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November 19, 2019 Cover
Pam Tillis keeps busy touring, making appearances and forever moving forward to her next musical project. Just last week she was a presenter for the Country Music Association awards with Women of Country Music as the theme.Country music is lucky to have her in their genre. But it wouldnt have mattered what Tillis chose to record and perform, she has one of those rare voices that lends itself to anything she wants to sing. She can easily move from classic country, to pop, to a bluesy torch singer wherever her heart, her soul and the lyrics lead.
Its rare when the puzzle pieces just seem to fit the first time a person opens the jigsaw box, but when Norm Stulz had the ability to make people laugh as early as the second grade in Detroit, there was no denying opening the comedy box was his lifes calling.Just a few years later in the seventh grade, he met the girl of his dreams and to this day, he and his wife Sharon, continue to build on a life together as two crazy kids in love. Laughter has been the glue for the relationship and the career path that has sustained Stulz for nearly 40 years.
Hosting a holiday dinner for your family is an undertaking in itself, but resorts are tasked with preparing the perfect menu for thousands of guests at multiple restaurants.Which items do guests want on the menu? How much food to order? When to start cooking? How many guests to prepare for? These are all questions the food and beverage departments must consider when planning for a holiday.
This time of year box stores are filled to the brim with every electronic device and latest phone known to man, but are there people on your list who already have all that stuff? Everyone has that one relative who is a challenge when comes to finding the perfect gift. Unique people require unique items and thinking outside the traditional box store offerings. Maybe that difficult-to-buy-for person is yourself because you never know what might strike your fancy.
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Not Just Weight Loss Intermittent Fasting Can Help You Lead Longer, Healthier Life Too; Know Other Health Benefits Of Following This Diet – NDTV News
Intermittent fasting is a popular weight loss diet which is loaded with amazing health benefits other than weight loss. When you consume fewer calories you lose weight. Intermittent fasting also reduces your calorie consumption along with time management. It is a quite popular diet which involves a cycle of fasting and eating. Intermittent fasting makes you follow a protocol that helps you fast in the proper way. Intermittent fasting has been widely used for weight loss. Following this diet is associated with more health benefits. A recent study has highlighted that intermittent fasting may lead to a longer and healthier life.
Intermittent fasting may sound like another diet fad but researchers have conclusively found that the practice of routinely not eating and drinking for short periods of time resulted in longer life in heart patients.
"It's another example of how we're finding that regular fasting can lead to better health outcomes and longer lives," said Benjamin Horne, principal investigator of the study.
Fasting affects a person's levels of hemoglobin, red blood cell count, human growth hormone, and lowers sodium and bicarbonate levels, while also activating ketosis and autophagy - all factors that lead to better heart health and specifically reduce risk of heart failure and coronary heart disease.
Also read:Intermittent Fasting: Know How To Practice It And The Benefits And Drawbacks That Follow
Type-2 diabetes is the most common type of diabetes which is affecting a huge population. Intermittent fasting has shown improvement in insulin resistance which lowers the risk of type-2 diabetes.
Intermittent fasting can help you control the risk of type-2 diabetesPhoto Credit: iStock
Many studies have shown that intermittent fasting can help in naturally fighting inflammation. Inflammation is a part of many health conditions. Intermittent fasting also helps in reducing oxidative stress.
As per the study mentioned above, intermittent fasting can help in reducing the risk of heart diseases and it can help you promote a healthy heart. It controls various risk factors which can lead to heart diseases like high blood pressure, bad cholesterol levels, inflammation and many more.
Studies have shown that intermittent fasting can help in boosting brain health. It also reduces the risk of Alzheimer's.
Intermittent fasting also helps on controlling the risk of Alzheimer's and improve brain healthPhoto Credit: iStock
Also read:Intermittent Fasting: Is It A Healthy Way To Lose Weight? Find Out Here
Fasting is not for everyone. Researchers cautioned that pregnant and lactating women should not fast, as well as young children and frail older adults. People diagnosed with chronic diseases - especially those who take medications for diabetes, blood pressure, or heart disease - should not fast unless under the close care and supervision of a physician.
Also read:Not Just Weight Loss But Intermittent Fasting Can Also Reverse Type 2 Diabetes: Here's The Right Way To Follow It
(With inputs from IANS)
Disclaimer: This content including advice provides generic information only. It is in no way a substitute for qualified medical opinion. Always consult a specialist or your own doctor for more information. NDTV does not claim responsibility for this information.
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The Women’s Health Issue That’s Finally Starting to Get Recognition – Worth
Long overlooked, menopause starts to get noticed as doctors and entrepreneurs see a market ripe for disruption.
Women are desperate to figure out why they dont feel good. By the time they come to see me, theyve been dismissed so many times, says Heather Hirsch, lead physician of Brigham and Womens Hospitals Menopause and Midlife clinic, set to open early next year. When we think about womens health, we talk about puberty, pregnancy and postpartum. The menopause transition is really important, and it gets no attention.
Hirsch, 37, is part of a new generation of doctors, tech developers and investors determined to change that, and aiming to replace stigma with public conversation, better medical research and more accessible training. Research for treatment of common symptoms like hot flashes, low libido, sleep disruption and weight gain is notoriously underfunded, they note, even as an estimated 38 million American women are menopausal and account for approximately 20 percent of the American work force.
The lack of medical research is coupled with a lack of clinical training, even for gynecologists.
In many family medicine, internal medicine and OB/GYN residency programs, there is perhaps an hour of instruction on menopause, at best, says Stephanie Faubion, medical director of the North American Menopause Society (NAMS) and director of the Mayo Clinic Center for Womens Health, where she co-authored the report Menopause Management Knowledge in Postgraduate Family Medicine, Internal Medicine, and Obstetrics and Gynecology Residents.
Anna Barbieri
Frustrated by misconceptions and shame surrounding the topic, doctors have found new ways to communicate with the women they say are deeply underserved. Hirsch has her own podcast series, Health by Heather Hirsch, with accessible and irreverent segments like Perimenopause, what the HEL! [sic]. In New York, a new telemedicine start-up called Elektra Health is recruiting doctors like Anna Barbieri and hosting frequent salon discussions with titles like Hormonal Harmony: Thriving in Perimenopause and Beyond.
Its important to provide current and valid information about symptoms and their management, and to discuss how this phase of life is so strongly related to other health factors, says Barbieri, 46, an assistant clinical professor of OB/GYN at Mount Sinai. We know, for example, that the time of menopause marks an increase in cardiovascular risk, diabetes risk and risk of dementia for women. How can we optimize this transition, and by doing so optimize other aspects of health? Menopause can vary widely from woman to woman, and were interested in how to practice patient-centered medicine based in evidence and rational treatments.
A reasonable approach, to be sure, but one hampered by myths and misunderstandings.
Among them, Hirsch says, is the fear of hormone replacement, largely stemming from media reporting on the early closure of a 2002 Womens Health Initiative study. That study, which examined one combined oral dose of estrogenand progesteronein a population of women whose average age was 63.5, was widelyandincorrectly interpreted as indicating that the hormones led to a significant increase in the risk of breast cancer and heart attacks.
WHI was an incredible research study with lots of information, but it was a skewed population of older, non-symptomatic women, Hirsch says. When the media spun the results, it made a huge impact in most peoples mind that estrogen is dangerous and harmful, and this idea is still very much ingrained into society.
Today, NAMS-trained providers say that hormone therapy, given to symptomatic women within 10 years of menopause (typically starting in their 50s), often has benefits.
Recent studies, Hirsch notes, say that women who take estrogen and progesterone within 10 years of menopause have a tendency to live longer, die less from all causes and have less heart disease. These are results from several large clinical trials ofdifferent preparations ofhormone therapy in women who start within 10 years of their last menstrual period.
Even when women are willing to take hormones, they are often confused about the best sources, struggle to find well-informed doctors and are susceptible to marketing of unregulated, compounded hormones, Hirsch says.
The compounded hormone therapy industry is extremely profitable, as they are preying off the insecurities of patients and then providers who are otherwise uncomfortable discussing the risks and benefits of FDA-approved hormone therapy, with the risks being overestimated, she notes. There are approximately 15 million women on hormone therapy, of which about two-thirds use unregulated and one-third use FDA-approved medications. However, this number could be larger if there are women using compounded HT we cannot account for. Therein lies another risk of inadequate education and counseling: women taking unregulated HT with the idea that it is safer.
Theres confusion, too, about how to use and source supplements like Chasteberry and Vitex, which some women take for PMS and irregular periods; silymarin, which supports liver function; and melatonin and valerian, which may help with sleeplessness and anxiety.
I find that the use of supplements in the U.S. can be controversial and polarizing, similar to hormone therapy, with many sharing either the extreme view that no FDA oversight means that herbs and supplements are mostly ineffective and can be dangerous, and others believing the opposite, that anything that is natural is safer and gentler than regular medications, says Barbieri. I fall in the middle and believe we should apply regular scientific principles to both drugs, many of which have botanical origins, and herbs/supplements.
This fraught climate, investors say, is ripe for growth.
Last year, market research firm Frost & Sullivan predicted that the market for femtechtechnology products that focus on female wellness, everything from reproductive health to general wellnesswill be $50 billion by 2025.
Jill Angelo
Women control the majority of healthcare dollars spent, and are so influential in their spending power, but I was really taken by the lack of attention to womens health in the second half of life, says former Microsoft executive Jill Angelo, 46. This is a huge opportunity, and in terms of how much is capitalized or consumed, were just getting started.
In September 2016, Angelo launched the online platform Gennev, initially focused on selling hygiene products geared toward easing menopausal symptoms. With her partner Jacqueline Brandwynne, a retired Neutrogena executive, Angelo has branched out to providing services to its 16,000 registered users. It now offers $35 telemedicine appointments with NAMS-certified physicians and a $10 monthly subscription to unlimited consultations with health coaches, dietitians and nutritionists specifically trained to counsel menopausal women. Gennev currently partners with physicians in 30 states and expects to cover all 50 states and the District of Columbia by the end of 2020.
We interviewed 1,500 women, and they said, I have no idea who to go see. My doctor brushes me off, Angelo says. Were still growing our product line into dietary supplements but have also expanded to telemedicine and on-demand coaching. Theres a lot you can do from a lifestyle perspective to alleviate symptoms.
Amy Domangue
Amy Domangue, cofounder and CEO of the virtual medical care aggregator Jessie, calls Angelo a pioneer. The opportunity for virtual care for menopause and perimenopause is finally giving women a place so they know exactly where to turn. The way our healthcare system works is outdated, Domangue says. We have primary care and OB/GYN doctors, but what if instead of general doctors you have specialists uniquely trained to your gender and age? How can we segment healthcare better, so people know where to turn?
And while some women in their 50s and 60s may be wary of virtual visits, Domangue and other menopause entrepreneurs predict the approach will soon become normalized.
Alessandra Henderson
Telemedicine has been around for a very long time, so the technology itself is nothing new, but user behavior is very much a consideration. How do you onboard women in a way that feels comfortable and natural and that builds trust from the get-go? As we grow over time, and continue to get more women on to the platform, well continue to see more digitally native women join, says Alessandra Henderson, 34, the cofounder and CEO of Elektra Health, a new company set to debut telemedicine services in 2020, starting with a beta test group of 30 women in New York state.
Elektras model is to focus on building a virtual care practice with a dedicated care team of gynecologists on staff.We believe dedicated Elektra providers trained in our proprietary care protocol is the best way to deliver an optimal customer experience, real healthcare results, as well as to foster a long-term relationship over the seven-to-10-year menopause journey, says Henderson. Another focus for Henderson: fostering community and accountability.
Elektra checks in regularly with women in the first week, month and beyond on not only their health goals but also their symptoms. Well then use that information to inform their next meeting with the gynecologist. We also plan to add women to private, curated groups for support and accountability, she says. One hundred percent of women go through this. Its nothing to be ashamed about. Its a natural, universal experience. We want to give women the tools to live really well during this time.
This perspective is long overdue, says Faubion, noting that despite the fact that most menopausal women will suffer symptoms, theres not a great deal of new research. One area that does look promising: phase three trials on drugs inhibiting receptors in the hypothalamus that are linked to brain pathways responsible for hot flashes and night sweats. They block the NK3 receptors believed to be in the hot flash neural pathway, but an exact mechanism hasnt been determined, Faubion explains.
Doctors emphasize that menopause should also be assessed in terms of how it may relate to other health issues, particularly cardiovascular disease and dementia.
There is basically a disruption in brain energy metabolism during the menopausal transition linked to decline in estrogen, Barbieri says, adding that the decline can leads symptoms like insomnia, disturbed sleep, hot flashes, depression and short-term memory impairment. It is this metabolic change, as well as recognized vascular changes that occur with menopause, including the impact on the brains vascular system, that may be linked to higher risk of dementia for women.
Ideally, Barbieri says, technology will help researchers target womens symptoms more precisely.
Id love to see research that focuses more on precision medicine for menopause and the choice of intervention based on ones particular genetic makeup and individual situation. That could translate to different types of medicines, dosing or modalities, she says. Id also love to see more research devoted to non-pharmaceutical approaches, including natural and mind-body approaches.
These are exactly the possibilities inspiring entrepreneurs like Elektras Henderson.
The more women that we treat, the faster we can help identify what is and is not going to work, she says. We have a lot of independent research studies on diet, acupuncture and meditation, but we are aiming to build an incredibly rich data set to help informwith hard, science-based evidencewhat has helped treat symptoms, as well as what are best practices.
An indispensable guide to finance, investing and entrepreneurship.
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The Women's Health Issue That's Finally Starting to Get Recognition - Worth
Are We Pretending Donald Trump Wasnt Secretly Rushed to the Hospital? – The Root
Pick one: Donald Trump was rushed to the hospital to visit a sick child because he is such a caring person... Or Donald Trump is the only president in history to break their physical examinations into two parts Or Donald Trump and the White House staff is lying.
Only one of those makes sense.
Trump is famous for eschewing presidential protocol, for instance, winning the popular vote; hiring competent people; and not soliciting Americas sworn enemies to undermine American democracy. But previously, he had adhered to the tradition of announcing the presidential physical and placing it on his public schedule.
But on Saturday, something strange happened.
Even though a letter from a quack physician reportedly called him the healthiest individual ever elected to the presidency, on Saturday, a presidential motorcade took Trump to Walter Reed National Military Hospital for an unannounced screening, according to NBC. Unlike his two previous exams, this surprise exam wasnt on his public schedule and no oneeven the staff at the hospitalseemed to know about it.
Furthermore, the medical visit came only nine months after Trumps last examination. Accompanied by the presidential physician and a weird yellow envelope attached to his curiously bulging coat, the colostomy bag of presidents insisted that he was visiting a sick child and undertaking an unprecedented two-part exam.
CNN reports:
His two previous physical exams in office were announced ahead of time by the White House and noted on his daily public schedule, but a source with knowledge of the matter told CNN Saturday that the Presidents unannounced trip to the medical center was not even on the Presidents internal schedule as of Saturday morning.
The Presidents motorcade drove to the medical center unannounced, with reporters under direction not to report his movement until they arrived Saturday at Walter Reed. Trump typically takes the Marine One helicopter to Walter Reed, but on Saturdays clear-skied day, the President opted for the motorcade.
Aside from intelligence briefings that usually includeand this is not a jokecolors and stories, Trumps calendar was cleared all day Saturday, Sunday and Monday.
While speculating on medical issues is an ill-advised practice, The Root has spoken with several medical professionals who offered a number of diagnoses, including:
While the impromptu medical visit reportedly took two hours, sources say that 45 minutes was spent in the hospital waiting room as the president read knock-knock jokes and staged a valiant but unsuccessful attempt at connecting the dots in the latest issue of Highlights magazine.
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Are We Pretending Donald Trump Wasnt Secretly Rushed to the Hospital? - The Root
What is a C-Section? Everything You Need to Know About the Procedure – Glamour
In the United States one third of women give birth by cesarean (aka C-section), a surgical procedure whereby your baby is delivered via an incision in your abdomen and uterus.
For being such a common (and medically necessary) procedure, people have a lot of feelings about ityou might have heard that its worse, a shameful alternative to delivering vaginally. Theres a lot of mommy shaming that occurs around C-sections, but the truth is C-sections can be a safer alternative for both mom and babyit all depends on your pregnancy and your history.
Since knowledge is power, we asked doctors to help explain when C-sections are typically used, what happens during the procedure, what recovery after a C-section looks like, and how they compare to vaginal births.
Its true that you can schedule a C-section to avoid having to worry about going into labor. Sometimes the hardest part of labor and vaginal delivery is the uncertainty, says Ashely Brant, D.O., an ob-gyn at the Cleveland Clinic. Its important for all parties to be flexible and open to changing the plan as labor unfolds.
Thats not lazy. There are a lot of medically valid reasons that your doctor might recommend going this route, says Costa Sousou, M.D., chair of the department of obstetrics and gynecology at Mayo Clinic Health System. Some of the reasons your doctor might suggest planning a C-section:
You have a condition called placenta previa.
Placenta previa is a condition that occurs when the placenta, an organ that develops during pregnancy to provide your baby with nutrients, covers the cervix (the tissue that connects your vagina to your uterus and opens during labor). That can lead to severe bleeding during pregnancy and delivery, says Sousou, meaning a C-section can be the safer alternative.
Youre pregnant with twins or triplets.
Depending on the babies positioning, a C-section may be the safer option.
Youve had a C-section before.
If you had a C-section with a previous delivery, there can be a small increased risk of uterine rupture (if you have prior uterine scars), explains Tajh R. Ferguson, M.D., an ob-gyn at Beth Israel Deaconess Medical Center in Boston.
Of course, just because you had a C-section once doesnt mean its 100% certain youll need to have one again. Deciding whether you want to schedule a repeat C-section or if you want to try vaginally calls for very individualized counseling with your physicianmuch of which is driven by patient preference if all else is healthy, Ferguson says.
Your baby is breech.
If your baby is not head-down (maybe hes butt-down, i.e., breech), vaginal delivery is dangerous if not impossible. Your doctor can try a procedure to turn the baby's head down, but if that doesnt work, a C-section may be the only option.
You have a history of trauma.
In rare cases, women may want to avoid vaginal delivery due to other circumstances, for example, a history of sexual assault that makes vaginal exams very difficult, says Brant. In cases like these, the patient should have a thorough discussion with her doctor about the risks and benefits of elective C-section."
Of course, there are plenty of scenarios for which your doc might order an unexpected C-section too. Some of those situations include:
Babys heartbeat dropping (which may indicate fetal distress).
Youre not progressing in labor (read: pushing for a long time without any progress).
Your doctor is worried about your health or your babys health. Oftentimes multiple factors contribute to the decision to have a C-section, says Brant. A doctor will recommend a C-section if the risks of vaginal delivery are thought to outweigh the risks of C-section.
If youre lined up for a C-section, first a nurse will prep you for the operation in an operating room, putting an IV in your arm or hand so that you can get fluids and medications such as antibiotics during the surgery.
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What is a C-Section? Everything You Need to Know About the Procedure - Glamour
Is There A Clinical Benefit To Asymptomatic Thyroid Function Screening? – MedicalResearch.com
MedicalResearch.com Interview with:
Dr. Richard Birtwhistle, ProfessorDepartments of Family Medicine and Community Health and EpidemiologyDirector of the Centre for Studies, Primary Care, Department of Family MedicineQueens University
MedicalResearch.com: What is the background for this study?
Response: Testing for thyroid dysfunction is a commonly done by primary care practitioners. While the Thyroid stimulating hormone (TSH) test is an easy blood test to perform results outside the normal range are often found and will revert to normal over time without treatment in patients without symptoms.
We wanted to see if there was any clinical benefit to patients by screening for thyroid dysfunction.
MedicalResearch.com: What are the main findings? What are the potential harms of over-testing for thyroid dysfunction?
Response: We did a systematic review of studies related to screening for thyroid dysfunction. We found no trials of screening for thyroid dysfunction. We analyzed studies (19 randomized trials and 3 cohort studies) of treatment of apparently screen detected patients. We looked for differences in mortality (total and cardiovascular), cardiovascular events (fatal and nonfatal MI, atrial fibrillation), fractures, thyroid specific quality of life, cognitive function and some intermediate outcomes such as blood pressure and cholesterol. Overall, the studies found no differences in these outcomes.
The potential harms of screening for thyroid dysfunction are related to the need for patients to have repeated followup blood tests, medical appointments and potentially unnecessary lifelong treatment. These potential harms can result in unnecessary worry for the patient, and use of resources (time and money) for both patients and the single payer health system.
We did not do any formal assessment of cost benefit because there appears to be no clinical benefit to patients.
MedicalResearch.com: What should readers take away from your report?
Response: We found several gaps in knowledge.
MedicalResearch.com: What recommendations do you have for future research as a result of this work?
Response: The task force uses the GRADE approach to assessing the evidence and making recommendations. No members of the working group had competing interests and one member of the task force reported developing an educational video on thyroid dysfunction but did not vote on the
Citation:
Recommendation on screening adults for asymptomatic thyroid dysfunction in primary care
Richard Birtwhistle,Kate Morissette,James A. Dickinson,Donna L. Reynolds,Marc T. Avey,Francesca Reyes Domingo,Rachel RodinandBrett D. Thombs;for the Canadian Task Force on Preventive Health Care
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Last Modified: Nov 18, 2019 @ 5:54 pm
The information on MedicalResearch.com is provided for educational purposes only, and is in no way intended to diagnose, cure, or treat any medical or other condition. Always seek the advice of your physician or other qualified health and ask your doctor any questions you may have regarding a medical condition. In addition to all other limitations and disclaimers in this agreement, service provider and its third party providers disclaim any liability or loss in connection with the content provided on this website.
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Is There A Clinical Benefit To Asymptomatic Thyroid Function Screening? - MedicalResearch.com
Everything You’ve Heard About Viral Texas Custody Case Is Wrong – Dallas Observer
If you happen to follow any of Texas' Republican leadership on Twitter and God bless you if you do you've likely encountered the state GOP's latest causeclbre: a child-custody dispute in Dallas County between a mom who says that one of her two 7-year-old twins is a trans girl and a dad who insists that the child chooses to dress and live as a boy when they're at the father's house.
A family court jury in the case initially awarded sole custody to the child's mother,Anne Georgulas, in late October before a state district judge overruled their decision and gave Georgulas and the child's father, Jeffrey Younger, joint custody, including joint responsibility over medical decisions affecting the child.
In the wake of the judge and jury's decisions, conservative media outlets like the Washington Examiner, The Texan and The Daily Wirepounced on the story, suggesting that Georgulas' and Younger's child might be "chemically castrated" or "mutilated" if left in Georgulas' care.
Politicians like Sen. Ted Cruz and Gov. Greg Abbott hopped on the bandwagon.
Comments like Cruz's are representative of the backlash against Georgulas. They're also screaming to be corrected.
Georgulas does not, as her representatives are careful to point out, intend to have her child placed on hormone blockers. Seven-year-olds don't go on hormone blockers, because they don't have sex hormones to block unless they're going through premature puberty, a condition for which doctors commonly prescribe hormone blockers.
"There are no medical interventions for prepubescent gender diverse children. The only thing to do at this stage is love and support your child,"Dr. Jack Turban, resident physician in psychiatry at Massachusetts General Hospital, where he researches the mental health of transgender youth, told the Observervia email.
Even for pubescent kids who do take hormone blockers, the drugs' effects can hardly be described as a medical transition. The drugs have been used for decades, according to Turban, and are safe.
"The risks associated with dysphoria toward puberty are typically much higher," he says.
If a kid elects to go off the blockers, they simply go through puberty.
"The only significant side effect is that the adolescent may fall behind on bone density. For this reason, doctors will regularly check bone density while the patient is on the medication," Turban wrote in an article published by Vox in October 2018. "If the medication is stopped, bone density catches up to normal after a few years as the child goes through the puberty of their gender assigned at birth."
Sex hormones if they are administered to teenagers at all are rarely started before a patient is 16, Turban says.
"Endocrine Society guidelines recommend age 16. In some instances where the gender history is very clear, estrogen or testosterone may be started as early as age 14," Turban says.
The only irreversible effects of sex hormone therapy, for teenagers or anyone else, are cosmetic changes like body fat redistribution and changes in body hair, Turban says.
"The greatest predictor of these kids doing well is when their parents love and accept them. Support your child and do not try to change them," Turban says. "If your child has questions about gender-affirming medical interventions, take them to a doctor who is knowledgeable about these options. Do not rely on information online, as much of it is misinformation."
Stephen Young has written about Dallas news for the Observer since 2014. He's a Dallas native and a graduate of the University of North Texas.
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Everything You've Heard About Viral Texas Custody Case Is Wrong - Dallas Observer
Ascendis Pharma Expands TransCon PTH Phase 2 PaTH Forward Clinical Trial to Expedite Enrollment of Subjects Previously Treated with NATPARA in the…
- Reflects company values and commitment to patients living with hypoparathyroidism -
- Top-line data from expanded PaTH Forward Trial expected in first quarter of 2020 -
- Company expects to exceed targeted enrollment of 40 subjects -
COPENHAGEN, Denmark, Nov. 14, 2019 (GLOBE NEWSWIRE) -- Ascendis Pharma A/S (ASND), a biopharmaceutical company that utilizes its innovative TransCon technology to address unmet medical needs, today announced a protocol addendum designed to facilitate enrollment of subjects previously treated with NATPARA (parathyroid hormone) for Injection in the United States (US) in PaTH Forward, a global phase 2 trial evaluating the safety, tolerability and efficacy of TransCon PTH in adult subjects with hypoparathyroidism (HP). TransCon PTH is an investigational long-acting prodrug of parathyroid hormone (PTH) in development as a potential once-daily replacement therapy for HP.
Previously, patients treated with NATPARA were required to undergo a long washout period prior to entering screening in PaTH Forward. In response to the recent recall of NATPARA in the US, Ascendis has been evaluating pathways to help enroll patients affected by the recall. Under the protocol addendum, patients previously treated with NATPARA in the US will now have an expedited pathway to enroll in PaTH Forward. As a result, the company expects to exceed targeted enrollment of 40 subjects in the trial.
This has been one of the most challenging times in the history of the hypoparathyroidism community, as we have navigated both the emotional and physical impact of the only PTH replacement therapy available being recalled in the US, said Deb Murphy, President and Vice Chair of the Board of Trustees of the HypoPARAthyroidism Association, Inc. We are grateful and very excited about Ascendis Pharmas efforts to expedite participation in the PaTH Forward Trial for additional patients.
Patients interested in participating in PaTH Forward in the US should discuss it with their physician, or visit pathforwardtrial.com, where they may contact a clinical representative who will refer them to a participating clinical investigator.
The unexpected recall of NATPARA in the US has had a major impact on my patients who have not been optimally controlled on standard of care with vitamin D and calcium supplements, said Mishaela Rubin, M.D., a PaTH Forward investigator. Patients living with hypoparathyroidism have an acute need to manage both their short-term symptoms and reduce risk of long-term complications. The PaTH Forward Trial is an opportunity for patients to participate in evaluation of a new potential treatment option for this debilitating disease.
PaTH Forward is a global, phase 2, randomized, double-blind, placebo-controlled, parallel group trial that will evaluate safety and efficacy of three fixed doses of TransCon PTH. The goal of PaTH Forward is to evaluate TransCon PTH control of serum and urinary calcium, and identify a titration regimen for complete withdrawal of standard of care (i.e., active vitamin D and calcium supplements). The trial will include adult subjects with HP who are currently receiving standard of care or were previously treated with parathyroid hormone therapies at up to 40 sites worldwide. The PaTH Forward Trial will introduce a ready-to-use pre-filled pen device and assess disease-specific patient-reported outcomes. After four weeks of dosing, all subjects may enter an open-label extension period with the opportunity to receive TransCon PTH to evaluate long-term safety and efficacy.
About TransCon Technology
TransCon refers to transient conjugation. The proprietary TransCon platform is an innovative technology to create new therapies that optimize therapeutic effect, including efficacy, safety and dosing frequency. TransCon molecules have three components: an unmodified parent drug, an inert carrier that protects it, and a linker that temporarily binds the two. When bound, the carrier inactivates and shields the parent drug from clearance. When injected into the body, physiologic pH and temperature conditions initiate the release of the active, unmodified parent drug in a predictable release manner. Because the parent drug is unmodified, its original mode of action is expected to be maintained. TransCon technology can be applied broadly to a protein, peptide or small molecule in multiple therapeutic areas, and can be used systemically or locally.
Story continues
About Hypoparathyroidism (HP)
Hypoparathyroidism (HP) is a rare endocrine disorder characterized by insufficient levels of parathyroid hormone (PTH), resulting in low calcium and elevated phosphate levels in the blood. HP affects approximately 80,000 patients in the United States, the majority of whom develop the condition following damage or accidental removal of the parathyroid glands during thyroid surgery. Patients often experience decreased quality of life. In the short term, symptoms include weakness, severe muscle cramps (tetany), abnormal sensations such as tingling, burning and numbness (paresthesia), memory loss, impaired judgment and headache. Over the long term, this complex disorder can increase risk of major complications, such as extraskeletal calcium depositions occurring within the brain, lens of the eye, and kidneys, which can lead to impaired renal function.
Until recently, HP remained among the few hormonal insufficiency states not treated by replacement of the missing hormone. Standard of care with active vitamin D analogs and calcium supplementation do not fully control the disease and may contribute to risk of renal disease. As a result, patients with HP have an estimated 4-fold to 8-fold greater risk of renal disease compared to healthy controls.
About Ascendis Pharma A/S
Ascendis Pharmais applying its innovative platform technology to build a leading, fully integrated biopharma company focused on making a meaningful difference in patients lives. Guided by its core values of patients, science and passion, the company utilizes its TransCon technologies to create new and potentially best-in-class therapies.
Ascendis Pharma currently has a pipeline of three independent endocrinology rare disease product candidates in clinical development and has established oncology as its second therapeutic area of focus. Additionally,Ascendis Pharma has multi-product collaborations withSanofiin diabetes and Genentech in the field of ophthalmology and continues to expand into additional therapeutic areas for both internal and external development.
Ascendis is headquartered in Copenhagen, Denmark, with offices in Heidelberg, Germany and Palo Alto, California.
For more information, please visit http://www.ascendispharma.com.
Forward-Looking Statements
This press release contains forward-looking statements that involve substantial risks and uncertainties. All statements, other than statements of historical facts, included in this press release regarding our future operations, plans and objectives of management are forward-looking statements. Examples of such statements include, but are not limited to, statements relating to (i) the timing of the topline data from the PaTH Forward Trial, (ii) our ability to apply our platform technology to build a leading, fully integrated biopharma company, (iii) our expectations regarding our ability to create new and potentially best-in-class therapies and (iv) our product pipeline. We may not actually achieve the plans, carry out the intentions or meet the expectations or projections disclosed in the forward-looking statements and you should not place undue reliance on these forward-looking statements. Actual results or events could differ materially from the plans, intentions, expectations and projections disclosed in the forward-looking statements. Various important factors could cause actual results or events to differ materially from the forward-looking statements that we make, including the following: unforeseen safety or efficacy results in our TransCon hGH, TransCon PTH and TransCon CNP or other development programs; unforeseen expenses related to the development and potential commercialization of TransCon hGH, TransCon PTH and TransCon CNP or other development programs, general and administrative expenses, other research and development expenses and our business generally; delays in the development of TransCon hGH, TransCon PTH and TransCon CNP or other development programs related to manufacturing, regulatory requirements, speed of patient recruitment or other unforeseen delays; dependence on third party manufacturers to supply study drug for planned clinical studies and potential commercial sale, if approved; and our ability to obtain additional funding, if needed, to support our business activities. For a further description of the risks and uncertainties that could cause actual results to differ from those expressed in these forward-looking statements, as well as risks relating to our business in general, see our current and future reports filed with, or submitted to, theU.S. Securities and Exchange Commission(SEC), including our Annual Report on Form 20-F for the year endedDecember 31, 2018, which we filed with theSEConApril 3, 2019. Forward-looking statements do not reflect the potential impact of any future in-licensing, collaborations, acquisitions, mergers, dispositions, joint ventures, or investments we may enter into or make. We do not assume any obligation to update any forward-looking statements, except as required by law.
Ascendis, Ascendis Pharma, the Ascendis Pharma logo, the company logo and TransCon are trademarks owned by the Ascendis Pharma group.November 2019 Ascendis Pharma A/S.
Internal contact: Scott T. Smith Chief Financial Officer (650) 352-8389ir@ascendispharma.com
Media contact:Ami KnoeflerHead of Global Communications(650) 739-9952 ack@ascendispharma.com
Investor contact:Patti BankWestwicke Partners(415) 513-1284patti.bank@westwicke.com
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Ascendis Pharma Expands TransCon PTH Phase 2 PaTH Forward Clinical Trial to Expedite Enrollment of Subjects Previously Treated with NATPARA in the...
What to anticipate from Intercourse After Having A Baby – ESPBR
What to anticipate from Intercourse After Having A Baby
Pregnancy and distribution modification great deal regarding the human anatomy, along with your sex-life.
Postdelivery hormone changes will make tissue that is vaginal and much more sensitive and painful. Your vagina, womb, and cervix have actually to return to size that is normal too. And when youre nursing, that may reduce libido.
Theres no timeline that is definitive says just how long you really need to wait to possess intercourse after having a baby. Nonetheless, many health practitioners suggest ladies wait 4 to 6 months carrying out a genital distribution.
After your medical professional has provided you the all clear to resume intimate tasks, you might still have to take things gradually. Keep in mind: as well as recovery that is physical youll also be adjusting up to a brand new member of the family, less rest, and a modification of your regular routine.
Its also possible to need certainly to wait much longer when you yourself have a perineal episiotomy or tear. An episiotomy is really a medical cut to widen the canal that is vaginal. Going back to intercourse too quickly may raise your chance of problems, such as for example postpartum hemorrhage and uterine infection.
Keep reading to find more info on the results of being pregnant and distribution on intercourse, and just how to possess a healthy, satisfying sex life after infant.
Intercourse after distribution shall feel various. One study that is small 2005 discovered that 83 % of females skilled sexual dilemmas in the 1st 90 days after their very very first distribution.
Nonetheless, that quantity will continue to fall due to the fact months that are post-pregnancy.
Hormones perform a large role in postdelivery data recovery and a come back to normal sexual intercourse.
When you look at the days childbirth that is immediately following estrogen falls to pre-pregnancy amounts. If nursing, estrogen levels might sink below pre-pregnancy levels. Estrogen helps provide natural lubrication that is vaginal therefore lower levels associated with hormone raise the probability of vaginal dryness.
Dry muscle can cause discomfort, also bleeding, while having sex. This increases your chance of illness.
Genital delivery can temporarily extend the muscle tissue associated with the canal that is vaginal. These muscles require time and energy to recover their stability and strength.
You may have a longer recovery if you had a perineal tear or episiotomy during vaginal birth. Making love too early can boost your threat of an infection.
A cesarean distribution also can impact sensation that is vaginal your brides website. Equivalent hormone problems could make the cells for the vagina dry and thin, perhaps resulting in painful intercourse.
Plus, youll be coping with stomach surgery, therefore youll desire to ensure that the incision web site has precisely healed before resuming intercourse.
You may get expecting interestingly quickly after delivering an infant. One research discovered the first ovulation for women that werent nursing is about six days. Some females ovulated even early in the day.
If youre nursing, the hormonal advantages of medical can behave as a natural type of contraceptive when it comes to first 4 to 6 months after distribution.
But, no more than 1 in 4 ladies who utilize this lactational amenorrhea method (LAM), or nursing as birth prevention, do therefore properly. That increases their danger for maternity.
If youre going to possess intercourse after pregnancy but dont want to risk another child therefore soon, intend to make use of a dependable approach to birth control.
A barrier technique, such as for instance a condom, might be good to use in the beginning. An implant or IUD can be used also. But, hormone choices may impact nursing and that can additionally have particular dangers, such as for example an increased danger for bloodstream clots.
Consult with your medical professional concerning the right selection for you.
Getting pregnant too rapidly after one maternity can place you at an elevated danger for premature birth or delivery defects.
Healthcare experts encourage ladies to place their pregnancies. Any office of Womens wellness suggests waiting at the least one year between each maternity. In addition to March of Dimes suggests waiting eighteen months.
If youre reasoning about another child, speak to your medical care pro. Theyll certainly be many acquainted with your wellbeing history and provide more recommendations that are personalized.
Some regular bleeding as your uterus heals in the weeks immediately following childbirth, youll likely experience. Intercourse could potentially cause some blood loss that is additional.
Likewise, your vagina may be drier and more sensitive and painful in the early days after childbirth. This is why the muscle tissue slimmer, that may lead to tearing or damage. The vagina may also become inflamed and swollen. During these cases, bleeding is not uncommon.
In the event that bleeding during intercourse does stop within four nt to six months or it worsens, see your medical practitioner. Youve probably an irritation or tear that needs treatment before starting having sex once again.
The hormones estrogen and progesterone are necessary to your babys development that is healthy maternity. Additionally they are actually crucial to your sexual interest.
Quantities of these hormones are extremely high during maternity. When the child is born, they decrease considerably, back again to levels that are pre-pregnancy.
Which means you might not feel any desire that is sexual a couple of months. However you ought to be waiting 4 to 6 months anyhow, as the human body recovers.
After your medical professional has offered you the all clear to resume activities that are sexual you may possibly opt to wait much longer before reigniting your sex-life. One research unearthed that 89 per cent of females had resumed sexual intercourse within 6 months of pregnancy.
If youre nursing, it may simply simply take additional time for the libido to go back than it might for females whom arent nursing. Thats because nursing keeps estrogen levels low.
Estrogen supplements are discouraged if youre nursing as it may affect milk manufacturing.
You and your partner may not feel like intimacy is even on the books when you couple changes in hormones with the fatigue of being a parent to a newborn.
As the human body adjusts to its brand brand new normal or once you stop breastfeeding, the hormones will start working once again, along with your libido should get back.
Pregnancy contributes to large amount of real modifications to your system. Thats why it is crucial to offer your self 4 to 6 days after distribution just before have sexual intercourse once again.
Throughout your recovery duration, the womb will shrink, hormones will come back to pre-pregnancy amounts, and muscle tissue will regain power and security.
Once youve been because of the go-ahead by the medical practitioner, be sure to simply take returning to intercourse to your time.
If any pain is experienced by you or symptoms that persist, consult with your physician. Painful intercourse may be an indicator of other conditions unrelated to pregnancy data data recovery.
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What to anticipate from Intercourse After Having A Baby - ESPBR
‘Conscience rule’ that puts providers’ personal beliefs ahead of patient’s emergency needs deemed unlawful – Northern Kittitas County Tribune
SPOKANE A federal judge in Spokane today ruled that the White House Administrations conscience rule is unlawful, granting summary judgment in Attorney General Bob Fergusons legal challenge. The rule would have given health care professionals broad discretion to refuse lawful and medically necessary care to patients for religious or moral reasons, even when the patients life is at risk.
This case represents the Washington Attorney Generals 25th consecutive legal victory against the Administration.
The court agreed that all Washingtonians deserve to receive the full range of health care services, Ferguson said. This rule would have disproportionately harmed rural and working poor Washington families, who have no alternatives to their local health care providers, as well as LGBTQ individuals, who already face discrimination when they seek medical care.
The lawsuit, filed in U.S. District Court for the Eastern District of Washington, argued that the rule would jeopardize access to reproductive health care, particularly for low-income, rural and working poor patients and allow providers to discriminate against LGBTQ individuals.
The conscience rule would have allowed health care workers to deny a patient access to medical care and services including reproductive care, end-of-life decisions, and care for transgender patients for moral or religious reasons, with no exception for medical emergencies. Under the rule, if the federal government believed Washington, its health care institutions, or other recipients of federal health care funds violated the rule, the federal government would be allowed to cut off all health care funding to the state more than $10 billion per year.
Ferguson filed the lawsuit in federal court in Spokane because rural communities, including those in Eastern Washington, have fewer health care providers and would be more likely to be harmed by the rule.
On Nov. 6, a federal judge in New York found the rule was unlawful and struck it down nationwide. Todays ruling provides an extra layer of protection against appeal by the Administration.
The conscience rule
The rule would have significantly expanded the number of individuals eligible to make refusals based on religious or moral beliefs. The rule applies to any employee providing any service to any patient, from ambulance drivers to receptionists to customer service representatives at insurance companies.
Some examples of potential impacts under the rule:
-A woman experiencing a life-threatening miscarriage calls an ambulance to her home. The EMT or paramedic who arrives could refuse to transport her to the hospital because they may terminate the pregnancy, despite the risk to the health of the mother and the fact that the pregnancy is not viable.
-A patient in need of an IUD to treat a condition such as endometriosis could be denied coverage by her insurance company on moral grounds because an IUD is also birth control. The patient would be responsible for the entire cost of her treatment.
-A patient who suffers debilitating pain with menstruation, or constant menstruation, could be cured with a surgery to remove her uterus. Her doctor could refuse to tell her about that option if he or she personally opposed sterilization.
-An employer could offer unmarried employees only health coverage that does not cover birth control, or choose to provide only plans that do not cover birth control at all.
-A receptionist, citing religious or moral objections, could refuse to schedule an appointment for an LGBTQ patient.
-A pharmacist could refuse to fill a prescription for hormone therapy for a transgender person.
-If a doctor who objects to physician-assisted suicide on religious grounds treats a patient with a painful, terminal disease who wants to use Washingtons Death with Dignity Act, the doctor may refuse to transfer that patients medical records to a participating provider.
Impacts on Washington
The rule threatened severe sanctions on states that do not comply. Any failure or apparent failure to follow the rule would jeopardize all federal health care funding, which states rely on to provide critical and often life-saving care.
Washington receives $8.2 billion annually for its Medicaid and Childrens Health Insurance programs, and more than $10.5 billion every year in federal funding from the U.S. Department of Health and Human Services. Washington relies on those funds for essential public health programs, including the Childrens Health Insurance Program, HIV/AIDS and STD prevention and education, and substance abuse and mental health treatment.
The rule provided no information on how the federal government will determine the rule has been violated.
The rule would have substantially increased the risk of discrimination against patients on the basis of sex, sexual orientation or gender identity. Transgender patients already face discrimination in the health care industry, including denial of routine medical care, like physicals, diabetes treatments and flu shots. The rule would give providers more leeway to refuse to provide care to transgender patients and discriminate based on gender identity.
Washington has a network of laws that balances patients right to health care treatment with respect for personal conscience. These laws allow medical professionals to refuse to provide certain services based on conscience, except in an emergency to save a human life. They also require health care institutions and providers to ensure that no one is denied information about or timely access to health care, by, for example, advising patients of all options required by todays medical standards.
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'Conscience rule' that puts providers' personal beliefs ahead of patient's emergency needs deemed unlawful - Northern Kittitas County Tribune