Archive for the ‘Life Extension’ Category

NAD+ Cell Regenerator and Resveratrol Elite combines NIAGEN nicotinamide riboside and ultra-bioavailable forms resveratrol with quercetin and fisetin to create an innovative nutritional supplement for longevity and youthful cellular energy production.

Resveratrol is a well-known longevity and anti-aging supplement.1 Our Resveratrol Elite formulas contains trans-resveratrol, the form associated with beneficial biological effects.2-5 Resveratrol also promotes healthy insulin sensitivity, supports a healthy inflammatory response and has been shown to promote healthy endothelial function for a healthy cardiovascular system.4,6,7

A more bioavailable resveratrol

Weve combined resveratrol with galactomannan fibers from fenugreek seeds. This makes our Resveratrol Elite formulas up to 10 times more bioavailable. This means that the trans-resveratrol in our supplements reaches higher levels in your bloodstream and circulates longer than traditional, unformulated resveratrol.

Resveratrol and heart health

One way that resveratrol promotes heart health is by helping to shield the body from oxidative stress at the cellular level.8 By inhibiting oxidative stress in your cardiovascular system, resveratrol promotes endothelial healthan essential component of living a long, healthy life.9

Resveratrol and brain health

At the same time, resveratrols ability to support cerebrovascular blood flow may also make it good for your brain: there is clinical evidence that resveratrol can help encourage youthful neurological function and with it, things like cognition. Interestingly, this same trial showed that resveratrol promoted healthy glucose metabolismanother essential aspect of healthy longevity.10

Fight general fatigue with NIAGEN

Nicotinamide riboside increases your bodys levels of NAD+, a coenzyme critical to healthy cellular function.11 In a randomized controlled trial published in 2017, older adults taking a daily dose of 250 mg of nicotinamide riboside had a 40% increase in NAD+ levels after just 30 days.2 Studies in preclinical models have shown that increasing NAD+ also encouraged healthy metabolic and cognitive function.3,4

Fisetin and quercetin

Fisetin and quercetin are phytonutrient compounds that augment trans-resveratrols healthy effects, promote cardiovascular health, support healthy cellular function, fight oxidative stress, promote a healthy inflammatory response and more.9,10

Take the fight against aging to the cellular level with NAD+ Cell Regenerator and Resveratrol Elite.

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NAD+ Cell Regenerator and Resveratrol Elite - Life Extension

USAs Alcor Life Extension Foundation has claimed that it will soon develop the scientific way to rebirth. The company, in USAs Arizona, has preserved the dead bodies of around 199 people only with the hope that once the technique is developed, they will get respite from their illnesses, and they will come back to life. With this hope of these people getting their lives back, Alcor has reserved their dead bodies in nitrogen tanks and the company calls them patients who lost their lives because of illnesses like cancer, paralysis, amyotrophic lateral sclerosis, etc.

Dead bodies preserved this way are called cryopreserved. Among these bodies, the youngest is that of a Thai child, who had lost her life at the age of 2 because of brain cancer in the year 2015. Alcors CEO, Max Moor has said that both of the childs parents are doctors and despite getting multiple brain surgeries performed on her, nothing helped. Hal Finney, who pioneered bitcoin, is also a patient at Alcor. After he lost his life in 2014 due to paralysis, his body is being preserved here.

The process of cryopreservation is highly different, after the legal announcement of a persons death, the blood and other fluids from the body are ejected out, which are then replaced with special chemicals, which prevent the boy from getting damaged, after which the dead body is preserved in extremely cold temperatures like glass.

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Alcor Life Extension Foundation preserves 199 dead bodies in nitrogen - Goa Chronicle

Oct. 15Kauai County will give out thousands of free home test kits next week at various neighborhood centers.

The county, in partnership with the state Health Department, is offering about 6, 000 COVID-19 tests kits on a first-come, first-served basis, starting Wednesday. There will be a limit of five tests per person or household.

"Mahalo to our partners with the Kauai District Health Office, the Department of Parks and Recreation, and the Kauai Emergency Management Agency for making these free tests available to our community, " said Mayor Derek Kawakami in a news release. "Home test kits are one of the many tools at our disposal to reduce the risk of spreading COVID."

These COVID-19 tests have an expiration date of November 2022, officials said, but have received a seven-month shelf-life extension from the U.S. Food and Drug Administration. They are set to expire in June.

The distribution schedule will be as follows :

Wednesday9 a.m. to noon, Hanalei Neighborhood Center1 to 4 p.m., Kilauea Neighborhood Center Thursday9 a.m. to noon, Waimea Neighborhood Center1 to 4 p.m., Hanapepe Neighborhood Center Friday9 a.m. to noon, Bryan J. Baptiste Sports Complex1 to 4 p.m., Lihue Neighborhood Center COVID-19 testing is also available islandwide on Kauai, with sites listed at.

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Kauai County to hand out thousands of free COVID home test kits - Yahoo News

Cryobiology illustration generated using Midjourney generative AI

Have you ever thought about what would happen if you suddenly need organ transplantation, but no one you know who is willing to donate is a match? An integral part of organ transplantation is, of course, donors and recipients, or people who donate the organs for matching people in need. They are registered within the Organ Procurement and Transplantation Network, an organization that arranges everyone on donor-recipient lists taking into consideration the severity of their illnesses. Their database contains all detailed information on blood and tissue types, organ sizes, medical urgency, and the geographical distance between the donor and the recipient. As soon as there is a newly available organ, a match is found throughout their database and shipped as soon as possible. Or at least thats how the system aims to work.

But there is a hidden player - cold. From Ancient Greece and Rome to modern days, our society has utilized cold in many ways, mostly to preserve food. However, in modern medicine, cold was also found in quite a few applications, such as freezing human sperm and embryos in the process of in vitro fertilization. Intuitively, modern medicine also futuristically looks at cold as a useful agent that could save our lives many years ahead, in the sense of preserving (freezing) our bodies now, and reviving them once we find the cures for untreatable diseases that may have impacted us.

But, coming back to organ transplantation, cold plays a huge role in this process. Once the organ has been removed from the donor's body, it needs to come to the recipient in the exact same functional state. Several external and environmental conditions can severely damage the organ until it's no longer of use. One of the key factors is temperature, which needs to be low enough to slow down biochemical reactions happening in the organ after extraction to prevent further damage. To successfully transport and deliver organs, they need to be kept on ice (a term called hypothermic storage), with an average temperature of +4C. Unfortunately, the heart and lungs can survive on ice for only about 4-5 hours, after which theyre no longer usable. Human organ transplantation requires intense immunological screening of both the donor and the recipient, and this period is usually insufficient to perform it. Finally, 4-5 hours is not enough for an organ to travel from Europe to the United States, for example. It's not even enough to travel within the United States, depending on the ending location, and in many cases, when paired with other logistical constraints, not even sufficient to travel from hospital to hospital. Therefore, geographical location plays a huge role in organ transplantation, and organs that cannot be delivered in a timely manner in optimal conditions will simply be lost. And that's exactly what happens because about 28 thousand organs are wasted in the United States only per year, due to poor performance of currently available preservation methods.

French Blood Bank In Bordeaux. Blood Transfusion Center, Storage Room For Stem Cells In Nitrogen ... [+] 196C. Open Vat Containing Bags Of Stem Cells. Stock Room For Cellular Therapy. (Photo By BSIP/UIG Via Getty Images)

The field of science that investigates the application of cold on biological samples is called cryobiology, whereas the process of using cold to preserve those samples is called cryopreservation. There are quite a few scientific groups, working both in academia and industry, that keep expanding the knowledge in these fields every day. The process of cryopreservation entails many steps, mainly cooling, storage, and rewarming. Each one of these steps can be divided into multiple reactions, and all of them could be performed in multiple ways. It is, however, vital that all of them are performed in an optimal way such that the biological sample that's being preserved does not get damaged, or lose its functionality upon reviving. The main problem in cryopreservation is the formation of ice crystals, that can happen at any step of the way, but mostly when samples are being either cooled to or warmed from subzero temperatures. This is a major issue because the largest part of all biological samples is water. Therefore, many research groups in cryobiology are working on ways to avoid ice crystal formation.

If successful cryopreservation and reviving of complex biological samples, e.g. human organs, was made possible without the interference of ice crystals, organs could be easily transported throughout the world without considering the time it would take to get them to their final destination or be stored for a long time until somebody would need them, as opposed to discarding and losing hundreds of them on a daily basis. Similarly, even if their functionality could be prolonged to a few days instead of a few hours, tens of thousands of human lives could be saved every year. Some researchers dedicated their whole careers to making this happen, and today I will introduce you to one of them.

In my last article on cryopreservation, I had the pleasure of interviewing the group of Dayong Gao, that works on methods to improve reviving of frozen biological samples using single-mode electromagnetic resonance rewarming. Today, I'm interviewing Matthew J. Powell-Palm, an Assistant Professor of Mechanical Engineering and Materials Science at Texas A&M University, and a co-founder of BioChoric Inc. Following in the footsteps of his mentor Boris Rubinsky, he works on understanding the underpinnings of cryopreservation and manipulating the first major part of this process, i.e., freezing itself. The method they are establishing is called isochoric cryopreservation, a technique that could improve transplantation medicine immensely.

Cryobilogy in cancer

The History of Cryopreservation: Major Breakthroughs

By providing you a little bit of historical context, well have a look over the major breakthroughs that happened in the field of cryobiology, and that instigated the modern use of cold in medicine. The start of the modern field of cryobiology is thought to have happened in 1948, when Christopher Polge discovered the cryoprotective effects of glycerol, a cryoprotective agent (CPA) that prevents ice crystal formation through the creation of bonds with free water molecules. Since then, a huge aspect of cryobiology and cryopreservation technologies was that we can modulate a given system's chemistry by involving CPAs, which could, in theory, allow us to preserve a live biologic sample for a long time. Many more CPAs, like dimethyl sulfoxide (DMSO), appeared on the scene afterwards, revolutionizing the subfield of human sperm cryopreservation. In 1972, scientists Peter Mazur, Stanley Leibo, and David Whittingham published evidence of the first-ever successful cryopreservation of mammalian embryos using slow-freezing. Eleven years later, the first-ever human embryo was cryopreserved.

A turning point in cryobiology happened in the 1980s, the so-called golden era of cryopreservation. Building on seminal early work by Father Basile J. Luyet, a Catholic priest and professor who helped to establish the thermodynamic foundation of modern cryobiology, Gregory M. Fahy and William R. Fall introduced the process of vitrification to medical cryopreservation. Vitrification is a process of rapid cooling of liquid medium until it becomes a glass-like non-crystalline amorphous solid. It requires the protective effect of CPAs, which lower the freezing point of water, as a major part of biological systems. In its vitrified state, water is locked in place, preventing the formation of ice crystals, and the entire sample becomes a glass-like solid. Vitrification is used widely today in the cryopreservation of very small biological samples (specifically in in vitro fertilization and other reproductive applications), and many cryobiologists believe it could eventually be applied to freeze any biological materials, even organs and whole organisms.

Human kidney frozen in ice cube, 3D rendering isolated on white background

Using vitrification, many research groups have already been able to successfully preserve and revive different cells and tissues, showing that there is major potential in cryopreserving and reviving organs as well. One of the major focus in cryobiology research is, in fact, centered around the process of vitrification and how much and which CPAs to add during this stage, or how to remove them in the rewarming stages. But, so far, CPA-aided vitrification only enabled the routine preservation of cells and cell suspensions and failed to produce any clinically translatable technique on how to preserve any complex biological systems like organs outside of the human body.

Isochoric Cryopreservation: Out With the Old, In With the New?

Methods in cryopreservation havent changed much in the last few years but there is a different approach currently available called isochoric cryopreservation. The term stands for cryopreservation of biological tissues at a constant volume, versus the more traditional way of cryopreservation that's done at constant pressure, called isobaric cryopreservation. During isochoric preservation, the cooling process happens in a confined, constant-volume chamber, representing one of the biggest differences between isochoric and isobaric conditions. Another difference is minimized role of CPAs, which are very much needed in the classical isobaric cryopreservation, but not in several modes of isochoric cryopreservation. The advantage of isochoric freezing is that it completely avoids the question of the toxicity associated with CPA usage as well as the amount of CPAs needed to be present in the biological sample you might want to freeze. Even if there is a need to use CPAs, their concentrations would be dramatically decreased. Under isochoric conditions, a biological sample is confined within a container with high rigidity and strength, usually made out of titanium. The container is completely absent of the bulk gas phase, and is denied any access to the atmosphere, which changes both the thermodynamic equilibrium and the ice nucleation kinetics within the system inside.

Isochoric cryopreservation is a technique conceived initially by Boris Rubinsky, a Professor at the University of California at Berkeley. Prof. Rubinsky obtained his Ph.D. at MIT in 1981 and has been engaged in the field of cryobiology ever since. His major research interests include heat and mass transfer in biomedical engineering and biotechnology and, in particular, low-temperature biology, as well as the development of bio-electronics and biomedical devices for clinical purposes. He has also pioneered in the fields of medical imaging, cryoablation, and non-thermal electroporation. Prof. Rubinsky has been involved with more than 470 peer-reviewed scientific papers since the beginning of his career and holds more than 30 US-issued patents.

The aim of isochoric cryopreservation at Prof. Rubinsky's group is not strictly preservation of biological samples (to be revived) per se, but rather about further developing the technique to offer the world a chance for a more successful general process of cryopreserving biological samples and decreasing the using toxic CPAs. Some of their latest research includes the creation of a quantitative approach to develop a general framework for the design of metastable supercooling protocols which incorporate the phase transformation and biochemical kinetics of the system. You can find the paper here. The group has also played with carbohydrate polymer protectants, as opposed to the small-molecular weight chemical ones mostly in use nowadays, and found that they can be used to manipulate the metastable-equilibrium phase change kinetics of the system at subzero temperatures. This approach has revealed that a carbohydrate polymer can be used to help modulate the stochasticity of ice nucleation in the supercooling system, which is important to designing supercooled biopreservation protocols for practical use. This research can be read here.

It seems the group is really striving to develop and optimize an application of supercooling and freezing techniques that could be used in biomedical devices already today. Some of Prof. Boris Rubinsky's technologies were already used to treat tens of thousands of patients, and the companies he founded were acquired by the big fish, such as Cryomedical Sciences which became a $300 million NASDAQ company. A new name in the field of isochoric cryopreservation is eager to follow in these steps, and to further develop the field in his own way: Matthew J. Powell-Palm.

Future Players in Cryo-thermodynamics: Professor Matthew J. Powell-Palm

Matt Powell-Palm is one of Boris Rubinsky's former PhD students and a leader in the field of isochoric cryopreservation. He is currently an Assistant Professor of Mechanical Engineering and Materials Science at Texas A&M University, and a co-founder of BioChoric Inc. (along with his former PhD supervisor), a medtech startup that is working on transforming transplant medicine by developing methods to prolong organ preservation. He obtained his Master's degree in 2016 at Carnegie Mellon University under the supervision of Jon Malen, and his Ph.D. in 2020 at UC Berkeley.

Currently, a central focus of Matt's research is within the field of isochoric thermodynamics and cryopreservation. His expertise revolves around the applications of isochoric supercooling and vitrification protocols and devices to improve organ preservation, conserve endangered marine animals, and improve global food storage and transportation. Even though he completed his Ph.D. only two years ago, he's already established himself as one of the leaders in the field of isochoric thermodynamics and cryopreservation with more than 25 published peer-reviewed scientific papers and numerous patents. I was honored to share the online space for some time with Matt and pick his brain on all things cryo, plus ask some additional futuristic questions.

Alex Zhavoronkov, PhD interviewing professor Matthew Powell-Palm via Zoom, September, 2022

First, I wanted to see what Matt's perspective was on different terms in cryobiology, and what he considers the differences between them.

Alex: Can you describe the differences between cryonics, cryobiology, and cryopreservation?

Matt: Cryopreservation is the application of cryobiology, and the biggest difference between it and cryonics is the end goal. The field of cryopreservation is not particularly interested in existential or societal aspects of life prolongation and is solving daily problems in medicine, conservation biology, agriculture, and in any application where the elongated shelf life is important. Cryonics is the application of cryobiology where the end goal is to prolongate a human life by freezing and reviving it in the future.

Alex: Can you talk about your current research and, specifically, the concept of isochoric cryopreservation?

Matt: Looking back on the many successes and failures of modern cryopreservation, I have been asking myself the past few years if there are any new non-chemical ways in which we can manipulate the thermodynamic behaviors of water to achieve the goal of preventing ice crystal formation below the systems melting point, which is the main problem in cryopreservation.

The umbrella technique the Rubinsky Lab has come up with leverages the effect of confinement or constant volume thermodynamic properties to manipulate phase transitions and equilibria of water. In the world around us, we are always in communication with the atmosphere as this constant and infinite pressure reservoir, and the core premise of isochoric cryopreservation processes is that we may be able to affect the phase equilibria and kinetics of water and ice by denying them access to this constant atmospheric pressure. When we do that, the natural variables that describe their existence are now constant volume and temperature, not pressure and temperature. When we confine the volume of a given system, it has a huge effect on the relationship between water and ice. We all know water expands almost 10% upon freezing, and weve all left a bottle of water or beer in the freezer only to come back and find it exploded. So lets imagine what would happen if instead of having liquid in a glass bottle, we held it in an unbreakable titanium flask. Ice will form and try to expand, but now it can't break the container or push the water out. What happens? Ice will start to expand, but the flask won't break and will instead push back on the contents within, pressurizing the growing ice and the remaining water. As a result, only a small portion of the liquid will end up as ice, even at temperatures well below the freezing point.

And isochoric conditions affect not only the equilibrium between water and ice, but also the metastability of water, the vitrification process of water, and the ice nucleation and growth process. So we are working on a broad suite of thermodynamic techniques that arent dependent on chemical intervention but enable us to reach sub-zero temperatures without ice formation in a stored biologic, which opens up many new avenues for exploration in cryobiology.

Alex: Among the classical isobaric approaches used in cryopreservation with antifreeze agents, vitrification, and rapid reheating, how is isochoric preservation better?

Matt:

You can think of the isochoric effect as being a value-add to any system. Speaking generically, our data and research suggest that if you take any classical technique or system and conduct the same protocol not under atmospheric pressure, but instead under isochoric conditions, you will encounter a lower chance for ice crystal formation. For conventional vitrification for example, you need incredibly high concentrations of cryoprotectants, usually 7 to 10 mol/L, or up to 40-50 % of the weight ratio. By using isochoric conditions, we can relieve some of the work that the chemistry needs to do in aiding glass formation, facilitating the same process of vitrification using a lower concentration of cryoprotectants, but under isochoric conditions. Similarly we can supercool metastable systems with higher reliability by confining them, we can hold equilibrium systems in a passively pressurized ice-free state, and so on.

Ill note too that a lot of the classical cryobiology literature and techniques have focused on ultra-low temperature preservation that targets months or years-long preservation, but there are all kinds of pressing medical cryobiology problems that dont necessarily require that, the most obvious being full organ preservation, where shelf-life extension on the order of even a single day would be transformative. So theres been a notable shift in the last decade towards what the community calls high subzero methods, which operate in the 0 20C range and leverage processes that aim to be much less physically and chemically intensive on the biologic than something like vitrification. Were finding that isochoric techniques can be particularly useful in this domain too, because you enter the realm where totally-CPA free isochoric supercooling or isochoric freezing protocols are very possible.

Alex: What about rapid reheating by using microwaves? How does the isochoric approach help with this?

Matt: Our goal is to build our protocol so that we ultimately wont need rapid reheating, which is required to escape the high probability of ice crystal formation when rewarming biological samples. If we can decrease the probability of ice crystal formation across the board, we would decrease the need to use rapid reheating. For example, and although I can't talk about it in too much detail, we are collaborating with the Smithsonian Conservation Biology Institute on vitrifying whole fragments of endangered corals under isochoric conditions, which has never before been achievable. In preliminary data, we are able to reheat the system without problems at a ballpark rate of 100s of degrees C per minute. The more sophisticated electromagnetic heating techniques achieves warming up rates of thousands of degrees and up in small systems, and those methods are indeed very cool, but so far unneeded for our systems. Ill note too that another aspect of the rewarming challenge is heating the system without building up significant thermal stress, which can lead to cracking throughout the sample because of uneven heating. One advantage that the isochoric system appears so far to offer is that physically confining the volume can help stabilize the system against cracking. If your system is open to the atmosphere, as it warms, the outermost layer that's open to the environment can expand freely, and cracking can happen easily. In the isochoric system, the boundaries of the sample are constrained, and it can help with reducing thermal cracking.

Matt's answers really intrigued me. I have been looking at cryopreservation through the eyes of cryonics and improving medicine by being able to extend the time until we find cures for untreatable diseases, which would imminently save so many human lives. However, it seems one part of the field, which Matt is intensively developing with his colleagues, could help to save so many lives in the present time very soon. It seems like a real, graspable possibility.

However, this made me wonder about the field of cryopreservation I have been interested in for months now. We saw some major breakthroughs in the field a long time ago, but lately, it seems as if the progress has been really slow. Is it because the field has been focused on the complicated process of vitrification by using cryopreserving agents too much, or is there something else at play? I was interested in what Matt had to say about this.

Alex: Clearly, the field of cryopreservation has been around for quite soe time. Why did it not yet pick up?

Matt: This is a fascinating question thats obviously affected by many different factors both historical and contemporary, but one of the biggest as always is funding, plain and simple. In the 90s and early 2000s, there was vanishingly little money available for research on cryopreservation, and what money there was was sort of narrowly focused. In the last decade however, cryopreservation, which we now include under the larger umbrella of biopreservation, has become something of a space race, and funders as varied as NIH, USDA, DOD, and even NASA are now giving out money for low-temperature biopreservation research. For example, NASA is looking for ways to protect astronauts in the theoretical manned missions to Mars. Even though using cryopreservation techniques to achieve goals like that seemed like sci-fi only a few years ago, we are now seeing more and more adventurous cryopreservation ideas getting funded, and funded well, and this has enabled the modern cryobiology field to start operating at the pace expected of a cutting-edge, super-impactful branch of science.

Alex: What happened in the last 5 years in cryopreservation research that may result in a major breakthrough in industrial applications?

Matt: Oh yeah, the last 5 years have been huge. Im lucky to get to see watch this progress unfold from both the academic angle, as a professor, and the industrial and clinical angles, as a startup founder. The suite of core technologies driving cryopreservation these days has just exploded in the last half-decade or so, driven by key advances in our understanding of aqueous metastability and supercooling of bulk volume liquids, uses of electromagnetic effects and nanoparticles for rapid and uniform warming, new thermodynamic configurations like isochoric, and many more. These fresh approaches are driving work in all sorts of new applications, and bringing new interdisciplinary physical science angles to the field.

Supercooling alone is a potentially transformative technology for large clinical applications, e.g. to extend the shelf-lives of transplantable livers, hearts, kidneys, etc. Id put my money on that technique seeing the light of day in the clinic within the next 5 years, as some kind of self-contained supercooling device. In my company, we have an isochoric supercooling technique that I think can be ready for pre-clinical trials very soon, though I can't say too much there. But the potential public health benefit of stable supercooling is just tremendous. I mean, if you could extend the preservability of a heart by just 4-8 hours, you might save a thousand lives next year. Extend it by a day or two and you could potentially be saving tens of thousands of lives around the globe.

As a field, we don't need technologies that will take ten more years to develop and will enable indefinite storage of a human heartwe need technologies that will take ten more months to develop and will enable storage of a heart for just long enough to get it from the donor to the recipient!

Although Matthew didn't point it out now, he is also doing a lot of work on preserving and extending the shelf life of food, which is another pressing societal issue, given the rising problems of food waste in some regions of the world, and the lack of food in other regions at the same time. In one of the groups latest research papers, isochoric supercooling and freezing have been applied to freshly harvested pomegranate, with its shelf-life being successfully extended for a month. You can read the publication here.

At his young age, Matthew is already wearing two hats (as he candidly points out), one of an academic professor and researcher, and the other as a co-founder and owner of a start-up company called BioChoric Inc. The company carries on with its research on isochoric preservation and aims at putting applicable devices and methods on the medical market as soon as possible, with everything being rooted in peer-reviewed and solid-proof research. Matt shared with me what the first days of starting the company looked like, and what their main future goals are.

Alex: When did you start BioChoric Inc. and what drove you to it?

Matt: We started the company in 2020 during the COVID pandemic. It was a spinout out of UC Berkeley, with me and Boris Rubinsky as founders, and the impetus was a crop of data we got on the effects of isochoric conditions on the supercooling of water, which suggested to us that an isochoric supercooling approach may be immediately applicable to organ and tissue preservation. We have a couple of integral patents and papers that describe the premise that, by confining the system, we can stabilize water in a metastable supercooled state, and predict the behaviors of this state in a rigorous quantitative sense, which has so far proven very difficult in unconfined systems.

The underlying philosophy of BioChoric Inc. is the obligation we feel to make rapid if incremental progress in full organ preservation. The degree of donor organ waste and the number of people dying on organ transplanting lists every day is huge, and that made us look at everything with a more clinical perspective. That's what we're pushing forward with BioChoric, even though the company is very small for now. One unique thing about the company is that it represents most of the thermodynamic expertise surrounding isochoric systems in the world today, and we rely heavily on interdisciplinary academic collaborations to help us further build the confidence and evidence we need to start pushing our techniques to clinical markets. We haven't taken any outside funding and it's fully internal equity, even though we've been approached by investors several times. We want to make sure we are scientifically sterling, peer-reviewed, bullet-proof before we start trying for the clinic.

One of the side hats BioChoric wears is also building isochoric biopreservation platforms and devices for other labs interested in advancing the science, and the small profit we generate from that helps to sustain our early R&D efforts.

It seems Matt is fully focused on improving human lives in the sense of prolonging the time transplantation-ready organs can be preserved, and that's the main goal of BioChoric. However, Matt and Boris's company is not the only one out there that offers cryo-products, although it may be the only one with a focus on isochoric cryopreservation, at least for now. Let's see what Matt thinks about how his company compares to similar ones in the field of cryobiology.

Alex: How do you compare and compete with companies like Lorentz Bio or X-Therma? When do you think BioChoric Inc. will be ready to fundraise and go industrial-scale?

Matt: I think there are many great young companies popping up in this space, but I'm glad you bring up Lorentz Bio because it has sparked quite a bit of chatter in the community, and they're taking an approach opposite to ours I think. My generic observation is that they have tackled raising the big money first, presuming they can fill in the scientific blanks later. In our case, its the scientists who have built the company, and built it on a core piece of new science, and were presuming we can fill in the money blanks later! Both fine ways to approach the problem. But personally, Im not really in the business of speculation or gambling I'm here to make sure were producing rock-solid, air-tight science, and the fundraising aspects don't worry me as much. Maybe that's just my academic side coming out. I think historically though, companies with really high checkbook-to-scientist ratios often end up coming to companies with really high scientist-to-checkbook ratios, like ours, to license our scientifically-established techniques and products. So suffice it to say, were focused on the science first and everything else second, and we're shooting for both fundraising and expansion to industrial scale in the next two years.

As my final question, I asked Matt the same futuristic question I asked Dayong Gao's research group at the University of Washington's Center for Cryo-Biomedical Engineering and Artificial Organs in my first article on cryopreservation, which you can read here. Matt was brave enough to offer me a timeline in which we could see some real breakthroughs in cryonics, as opposed to only preservation.

Alex: When do you think we will be able to see isochoric cryopreservation being used to cryopreserve and revive a small mammal?

Matt: Interesting question! I would say within the next 5 years, we will certainly see isochoric preservation of endangered marine species. Marine biodiversity is such an unbelievably urgent problem, and we are thinking about expanding our research on coral to other marine organisms in the next few months. If things continue to go well, we may be looking at trying to deploy field-ready isochoric devices at every marine research station on Earth, as bombastic as that sounds! The problems there are just too pressing to wait. On the human organ scale, I think we will see the preservation of organs extended to at least single days within the next 5 years. And I also want to take this opportunity to give a shoutout to each and every research group working on this problem right now, because the many often divergent results from differing corners of the field each move us all forward.

I admittedly havent thought much about preserving small live mammals, so I cant speculate in a properly scientific fashion, but Ill speculate for fun! Current approaches would require us to preserve each organ of the mammal separately because the preservation process gets more complicated the more complex you go. Based on the progress in the last 5 years, we will probably see a supercooling approach to preserve every major organ separately within the next 5 years. I don't know what happens at one step higher if you would want to preserve a multiorgan construct, and what would be different about it in comparison to just one organ. The relationship of these animals with air is also more complex than with marine animals that live submerged in a liquid anyway. But as a cop-out, Ill go ahead and say that the timeline will once again depend really acutely on potential increases in funding, and it will depend on which aspects of the field will get the most funding. So, I would speculate we could see a small mammal preserved and revived in about 20 years if the funding goes in that direction. But in my opinion, there is much more pressing research to be done.

With such young and bright-minded scientists led by the field's giants, like the combination of Matthew J. Powell-Palm and Boris Rubinsky, cryopreservation is definitely looking at several major breakthroughs coming from all areas of the field in the next few years. Also, as Matt also smartly pointed out, progress coming from different areas of cryopreservation actually helps developing all areas of cryopreservation, as the complex process of cryopreservation itself is made of various tightly-bound and regulated steps that cannot work alone.

See more here:
Think Outside The (Titanium) Box: Isochoric Cryopreservation Could Save Lives - Forbes

In this article:

Everyone knows vitamin D -- it's the nutrient we get from the sun. Vitamin D is important for several bodily functions, the main ones being bone and muscle strength and immune function. Still, about 35% of Americans are vitamin D deficient. Research has found that vitamin D deficiencies and diseases like depression, diabetes and cancer are correlated.

Vitamin D is essential. But with winter coming and food source limitations, getting vitamin D isn't always as easy as walking out in the sun. Supplements are used to combat such deficiencies.

A note on units of measurement for vitamin D supplements -- different brands use different units in their marketing. Some measure in micrograms (mcg), while others use international units (IU). The nutritional label typically has both units and the percentage of the daily recommended value. It can get confusing.

Quick conversions that will help you read this list:

Vitamin D supplements span quality, dosage and price point. There are many options, but we narrowed it down to the top eight best vitamin D supplements.

Hum Nutrition Here Comes the Sun is the best overall vitamin D supplement because of its vitamin content and rigorous testing. According to the Hum Nutrition website, this vitamin D supplement boosts mood, maintains your immune system and aids calcium absorption.

It's a non-GMO and gluten-free vitamin D supplement free of artificial flavors, colors or sweeteners. With the serving size of one softgel, you get 250% of your recommended daily value of vitamin D. The vitamin D source was derived from lichen, which makes this vitamin D supplement great for vegans and vegetarians.

Hum Nutrition's vitamin D supplements are sustainably sourced and feature third-party testing.

Price: $19 for a 30-day supply

Vitamin D per serving: 50 mcg or 250% of the daily value

Serving size: One softgel, daily

Hum Nutrition's best features:

Things to consider:

Nature Made vitamin supplements are often my choice for budget shoppers because of the price, vitamin content and company reputation. The Nature Made Vitamin D3 Softgels are available in multiple dosages, so you can choose which works best for you. They have dosages from 25 mcg to a maximum of 250 mcg.

You really can't beat the price of Nature Made. You can get up to a 250-day supply for under $20. Not to mention that the softgels are small and easy to swallow -- and you only have to take one per day.

Price: $16.93 for a 250-day supply

Vitamin D per serving: 50 mcg or 250% of the daily value

Serving size: one softgel, daily

Nature Made's best features:

Things to consider:

If you have trouble swallowing pills, liquid vitamin D options are available the best of which is Pure Encapsulations Vitamin D3 liquid.

It's a small bottle that's easy to transport, which allows you to add it to food anywhere. It's also flavorless. Liquid supplements give you the flexibility that capsule or pill supplements can't. You can also alter the dosage based on seasons and needs. Remember to always pay close attention to how much you're ingesting.

This vitamin D supplement is sourced from lichen. It includes no artificial flavors and is gluten-free and non-GMO. Pure Encapsulation products are third-party tested by organizations like Advanced Laboratories, Eurofins and Intertek.

Price: $29.55 for 22.5 ml bottle

Vitamin D per serving: 25 mcg or 125% of vitamin D of the daily value

Serving size: One drop, daily

Pure Encapsulations' best features:

Things to consider:

For people who need a higher dose of vitamin D, -- those with malabsorption syndromes, osteoporosis or liver failure -- Life Extension Vitamin D3 supplement is a good choice. Most vitamin D supplements have 25 mcg to 50 mcg. The vitamin D supplement from Life Extension offers 125 mcg or 5,000 IU, which is significantly more than other brands.

Given this vitamin D supplement has such a high dosage, it's important to speak to your doctor before taking it. It shouldn't be taken by the average person who doesn't need a huge boost of vitamin D. Life Extension's bottle label advises you to meet with your doctor for regular blood tests to determine your vitamin D levels.

Price: $15.17 for a 120-day supply

Vitamin D per serving: 125 mcg or 625% of the daily value

Serving size: one softgel, daily

Life Extension's best features:

Things to consider:

Many vitamin D supplements happen to be vegan. However, Truvani is the best vegan vitamin D supplement. It's a plant-based and USDA-certified organic supplement sourced from organic lichens that doesn't include additives or processed ingredients. This vitamin D supplement has an average amount of vitamin D at 50 mcg. This vitamin D supplement comes in a small, uncoated tablet. It's easy to swallow, but you can also add it to smoothies or drinks and let it dissolve.

Price: $14.99 for a 30-day supply

Vitamin D per serving: 50 mcg or 250% of the daily value

Serving size: one tablet, daily

Truvani's best features:

Things to consider:

Nordic Naturals Vitamin D3 Gummies are an all-natural supplement free of artificial sugars or additives. With this vitamin D supplement, you get a solid dose of vitamin D without all the extras that gummy vitamins tend to have.

This gummy vitamin D supplement features a wild berry flavor with organic sucrose and fumaric acid sour berry coating. An important thing to note is that while the sugars included are not artificial (organic sugar cane and organic tapioca syrup), there are still two grams of added sugar in this product. It's not the highest I've seen, but it's something to consider if you watch your sugar intake closely. Added sugars are extremely common in the gummy industry -- that's how they get their delicious flavors. Unlike other brands, Nordic Naturals also offers a zero-sugar version sweetened with xylitol.

Price: $12.07 for a 30-day supply

Vitamin D per serving: 25 mcg or 125% of the daily value.

Serving size: 1 gummy, daily

Nordic Naturals' best features:

Things to consider:

Ritual is a well-known vitamin subscription service. It's the best multivitamin with vitamin D because of its traceable ingredients and dense nutrient content. According to Ritual, the Essential Multivitamin helps bone health, brain health and immune function.

Ritual multivitamins include a vegan D3 ingredient made from UK-sourced lichen. With each serving, you get 50 mcg of vitamin D, double what some supplements offer. Since it's a multivitamin, you get additional nutrients like folate and iron.

Ritual supplements are backed by a clinical study that found that the Ritual Essential Multivitamin for Women resulted in a 43% increase in vitamin D levels. It's worth noting that Ritual was involved in the study.

Price: $30 for a 30-day supply

Vitamin D per serving: 50 mcg or 250% of the daily value.

Serving size: two capsules, daily

Ritual's best features:

Things to consider:

Vitamin D is essential for pregnancy as it aids in the development of a baby's bones. Vitamin D deficiencies during pregnancy have been linked to newborns' disordered skeletal homeostasis or fractures. Experts recommend that pregnant women intake up to 4,000 IU (100 mcg) of vitamin D3 daily to prevent preterm births and infections.

Most vitamin D supplements don't offer that much vitamin D3 per serving. However, the FullWell Prenatal Multivitamin does. Developed by a fertility nutrition expert, FullWell supplements are non-GMO and free of common allergens like nuts, dairy, gluten and shellfish.

FullWell Prenatal Multivitamin includes the recommended 4,000 IU of vitamin D and all other nutrients a pregnant person needs -- like vitamins A, V, E and B6. This supplement also offers a hefty dose of pantothenic acid at 2,143% daily value and biotin at 1,429%.

Price: $49.95 for a 30-day supply

Vitamin D per serving: 100 mcg or 667% of the daily value

Serving size: eight capsules, daily

FullWell's best features:

Things to consider:

When choosing the best vitamin D supplements for this list, we considered factors like price, dosage and vitamin D source. We also paid close attention to third-party certifications that the products carry. Due to the limited FDA regulations in the vitamin and supplement industry, third-party testing and certifications are essential to determine product quality and purity. We did not test these products in-house. We relied on customer reviews for things like taste and ease of swallowing.

Our bodies need vitamin D, and as a result, there are a ton of supplements out there with vitamin D in them. From pure vitamin D supplements to multivitamins or prenatal supplements, there tends to be vitamin D in all of them. So which vitamin D supplement should you buy?

When shopping for vitamin D supplements, keep these key factors in mind:

What's the difference between vitamin D and D3?

Vitamin D is broken down into two main forms -- vitamin D2 and D3. The difference is where they come from. Vitamin D2 (ergocalciferol) is found in plant sources like mushrooms or fungi. Vitamin D3 (cholecalciferol is derived from animal sources.

How often should you take vitamin D supplements?

Unlike other nutrients, our bodies store vitamin D in fat cells, which allow them to release it when needed. Many supplements with higher doses of vitamin D are not designed to be taken each day since there likely already is some stored in the body. Taking too much vitamin D can result in stomach discomfort, weight loss and kidney issues. A lower vitamin D supplement is considered safe, particularly if you're deficient in vitamin D.

The information contained in this article is for educational and informational purposes only and is not intended as health or medical advice. Always consult a physician or other qualified health provider regarding any questions you may have about a medical condition or health objectives.

Excerpt from:
8 Best Vitamin D Supplements to Take This Winter - CNET

ProLynx LLC

SAN FRANCISCO, Sept. 20, 2022 (GLOBE NEWSWIRE) --

ProLynx, Inc., a biotechnology company with a novel platform technology for half-life extension of therapeutics, enabling novel and potentially best-in-class treatments to be developed, today announced that Richard King, MBA, has been appointed as Chief Executive Officer and as a member of the Board of Directors. Additionally, Chris Ehrlich, MBA, has joined the company as a member of the Board of Directors.

As a seasoned executive in the industry with a track record of success in partnering, Richard is an excellent fit forProLynx,saidBill Rutter,a ProLynx Board member. The ProLynx Board looks forward to working with Richard and the executive team to realize the promise of our innovative technology for the betterment of patient and caregiver lives. Additionally, I am delighted to welcome Chris to the Board. His expertise in venture capital, business development and financing strengthen the capabilities of our Board.

Richard King is an accomplished executive with over 35 years of leadership experience in the biotechnology and pharmaceutical industries. He has raised over $1bn in private and public capital, completed multiple business transactions, including the sale of Tercica, Inc., the partnership of AcelRx and Grunenthal regarding a novel pain management system, and the strategic affiliation of CALIBR with the Scripps Research Institute.

I am delighted to join ProLynx at this time, saidRichard King. The ProLynx technology is incredibly unique, enabling half-life extension of proteins, peptides and small molecules. This advancement can make existing medications more effective, better tolerated and require less frequent administration. The ProLynx technology can also be applied to molecules in development that might otherwise never be advanced due to efficacy or toxicity issues, allowing these product candidates to move forward and possibly become life-altering treatments for patients.

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Chris Ehrlich began his career with consulting firm LEK before becoming a business development executive in the pharmaceutical industry. Subsequently he was Managing Director at venture capital firm InterWest, serving on multiple company Boards. He joined Locust Walk, a life sciences transaction firm, where, as Global Head of Biotechnology and Head of Strategic Transactions, he sourced and lead multiple transactions for emerging biopharmaceutical companies.

ProLynx is in a great position with its lead development program in clinical trials to treat various cancers, as well as multiple other programs having demonstrated proof of concept across a variety of disease areas, said Chris Ehrlich. I am delighted to join the Board to help bring this novel half-life extension technology forward to advance treatment options for patients in need.

AboutProLynx

ProLynx is a biotechnology company located in San Francisco, CA, developing proprietary drug delivery technologies for half-life extension of therapeutics. The ProLynx pipeline centers on a long-acting oncology drug, PLX038, in Phase 2 clinical trials, a long-acting interleukin 15, PLX015, for immuno-oncology and a very long-acting C-type natriuretic peptide, PLX138, for achondroplasia, together with several other early-stage programs.

Contact

Richard KingRichard@prolynxinc.com

Read more:
ProLynx appoints Richard King as Chief Executive Officer and Chris Ehrlich as Board Director - Yahoo Finance

As the world gets warmer, the use of power-hungry air conditioning systems is projected to increase significantly, putting a strain on existing power grids and bypassing many locations with little or no reliable electric power. Now, an innovative system developed at MIT offers a way to use passive cooling to preserve food crops and supplement conventional air conditioners in buildings, with no need for power and only a small need for water.

The system, which combines radiative cooling, evaporative cooling, and thermal insulation in a slim package that could resemble existing solar panels, can provide up to about 19 degrees Fahrenheit (9.3 degrees Celsius) of cooling from the ambient temperature, enough to permit safe food storage for about 40 percent longer under very humid conditions. It could triple the safe storage time under dryer conditions.

The findings are reported today in the journal Cell Reports Physical Science, in a paper by MIT postdoc Zhengmao Lu, Arny Leroy PhD 21, professors Jeffrey Grossman and Evelyn Wang, and two others. While more research is needed in order to bring down the cost of one key component of the system, the researchers say that eventually such a system could play a significant role in meeting the cooling needs of many parts of the world where a lack of electricity or water limits the use of conventional cooling systems.

The system cleverly combines previous standalone cooling designs that each provide limited amounts of cooling power, in order to produce significantly more cooling overall enough to help reduce food losses from spoilage in parts of the world that are already suffering from limited food supplies. In recognition of that potential, the research team has been partly supported by MITs Abdul Latif Jameel Water and Food Systems Lab.

This technology combines some of the good features of previous technologies such as evaporative cooling and radiative cooling, Lu says. By using this combination, he says, we show that you can achieve significant food life extension, even in areas where you have high humidity, which limits the capabilities of conventional evaporative or radiative cooling systems.

In places that do have existing air conditioning systems in buildings, the new system could be used to significantly reduce the load on these systems by sending cool water to the hottest part of the system, the condenser. By lowering the condenser temperature, you can effectively increase the air conditioner efficiency, so that way you can potentially save energy, Lu says.

Other groups have also been pursuing passive cooling technologies, he says, but by combining those features in a synergistic way, we are now able to achieve high cooling performance, even in high-humidity areas where previous technology generally cannot perform well.

The system consists of three layers of material, which together provide cooling as water and heat pass through the device. In practice, the device could resemble a conventional solar panel, but instead of putting out electricity, it would directly provide cooling, for example by acting as the roof of a food storage container. Or, it could be used to send chilled water through pipes to cool parts of an existing air conditioning system and improve its efficiency. The only maintenance required is adding water for the evaporation, but the consumption is so low that this need only be done about once every four days in the hottest, driest areas, and only once a month in wetter areas.

The top layer is an aerogel, a material consisting mostly of air enclosed in the cavities of a sponge-like structure made of polyethylene. The material is highly insulating but freely allows both water vapor and infrared radiation to pass through. The evaporation of water (rising up from the layer below) provides some of the cooling power, while the infrared radiation, taking advantage of the extreme transparency of Earths atmosphere at those wavelengths, radiates some of the heat straight up through the air and into space unlike air conditioners, which spew hot air into the immediate surrounding environment.

Below the aerogel is a layer of hydrogel another sponge-like material, but one whose pore spaces filled with water rather than air. Its similar to material currently used commercially for products such as cooling pads or wound dressings. This provides the water source for evaporative cooling, as water vapor forms at its surface and the vapor passes up right through the aerogel layer and out to the environment.

Below that, a mirror-like layer reflects any incoming sunlight that has reached it, sending it back up through the device rather than letting it heat up the materials and thus reducing their thermal load. And the top layer of aerogel, being a good insulator, is also highly solar-reflecting, limiting the amount of solar heating of the device, even under strong direct sunlight.

The novelty here is really just bringing together the radiative cooling feature, the evaporative cooling feature, and also the thermal insulation feature all together in one architecture, Lu explains. The system was tested, using a small version, just 4 inches across, on the rooftop of a building at MIT, proving its effectiveness even during suboptimal weather conditions, Lu says, and achieving 9.3 C of cooling (18.7 F).

The challenge previously was that evaporative materials often do not deal with solar absorption well, Lu says. With these other materials, usually when theyre under the sun, they get heated, so they are unable to get to high cooling power at the ambient temperature.

The aerogel materials properties are a key to the systems overall efficiency, but that material at present is expensive to produce, as it requires special equipment for critical point drying (CPD) to remove solvents slowly from the delicate porous structure without damaging it. The key characteristic that needs to be controlled to provide the desired characteristics is the size of the pores in the aerogel, which is made by mixing the polyethylene material with solvents, allowing it to set like a bowl of Jell-O, and then getting the solvents out of it. The research team is currently exploring ways of either making this drying process more inexpensive, such as by using freeze-drying, or finding alternative materials that can provide the same insulating function at lower cost, such as membranes separated by an air gap.

While the other materials used in the system are readily available and relatively inexpensive, Lu says, the aerogel is the only material thats a product from the lab that requires further development in terms of mass production. And its impossible to predict how long that development might take before this system can be made practical for widespread use, he says.

This work "represents a very interesting and novel system integration approach of passive cooling technologies," says Xiulin Ruan, a professor of mechanical engineering at Purdue University, who was not associated with this research. Ruan adds, "By combining evaporative cooling, radiative cooling, and insulation, it has a better cooling performance and can be effective in a wider range of climates than evaporative cooling or radiative cooling alone. The work could attract significant practical applications, such as in food preservation, if the system can be made at reasonable cost."

The research team included Lenan Zhang of MITs Department of Mechanical Engineering and Jatin Patil of the Department of Materials Science and Engineering.

Read the original here:
Passive cooling system could benefit off-grid locations - MIT News

Anderson, South Carolina--(Newsfile Corp. - September 20, 2022) - JZZ Technologies Inc.'s (OTC Pink: JZZI) ("JZZ" or the "Company")newly created digital marketing division has added 28 million new records to its database for marketing to U.S. healthcare products consumers.

JZZ Technologies, Inc. has acquired marketing data for more than 28 million U.S. healthcare product consumer records as part of its ongoing data acquisition efforts. These new records will be offered to Active Lifestyle Marketing customers as part of the Company's emerging marketing suite of products that includes 30+ million seniors, medical professionals, B2B contacts, 17 million metaverse users and now, 28 million healthcare products consumers.

The deal with a third-party provider requires that JZZ Technologies participate in a structured data sharing plan whereby JZZ and the data provider exchange records.

Email direct marketing is still considered among the most effective forms of digital advertising and the medical consumer segment offers one of the best yields in the industry. According to the digital marketing analysis group Wordstream, healthcare advertisers pay an average cost per click of $3.17 for ads through digital platforms. That compares to the average across all industries which is just $2.32 per click.

Using the comparable models for pricing, JZZ expects that its new record set can potentially generate up to an average of $315,000 per send. That is based on delivering a .5% click rate utilizing the entire new database with a 75% in-box delivery rate. The click rate may be higher or lower depending on individual marketing messages and other factors.

Charles Cardona, CEO of JZZ technologies, Inc. stated, "We will continue to broaden our product selection for Active Lifestyle Digital Media products as possible. The medical products consumers segment is naturally aligned with our audience of adults 55+ and it's a great source for digital income. We plan to focus on this segment as much as possible to maximize our potential for revenue."

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"We are beginning to generate revenue from our database with major digital service providers and that will start to really bear fruit in the next quarter," Cardona adds.

JZZ currently holds data sets for active adults age 55+, medical professionals, veterans, B2B contacts and many other segments. The total database of records owned and/or licensed by JZZ Technologies now equals roughly 70 million records. The Active Lifestyle Marketing division is continuing to segment the targeted data to include specific verticals such as individuals with diabetes, aging issues, and insurance consumers, among others.

About JZZ Technologies, Inc.

JZZ Technologies, Inc. is a diversified technology company engaged in digital media business which includes online media and apps (activelifestylemedia.com), content creation, and digital marketing, targeted to active adults 55+, strategic biotechnology and bioscience related to Human Life Extension and quality of life businesses that support improved quality of life for the aging population. For more information, please visit http://www.jzztechnologies.com.

Press Contacts:JZZ Technologies, Inc.Charles Cardona, CEOccardona@jzztechnologies.com

DISCLAIMER and FORWARD-LOOKING STATEMENTS

Certain statements contained herein are "forward-looking" statements (as such term is defined in the Private Securities Litigation Reform Act of 1995). Because such statements include risks and uncertainties, actual results may differ materially from those expressed or implied by such forward-looking statements. This press release may contain certain forward-looking statements within the meaning of Section 27A of the Securities and Exchange Act of 1933, as amended, and Section 21E of the Securities and Exchange Act of 1934, as amended, and such Forward-Looking Statements are intended to be covered by the safe harbors created thereby. Investors are cautioned that all forward-looking statements involve risks and uncertainties. All statements other than statements of historical fact in this announcement are forward-looking statements, including but not limited to the viability of the Company's business plans, the effect of acquisitions on our profitability, the effectiveness, profitability, and the marketability of the Company's products; the Company's ability to protect its proprietary information; general economic and business conditions; and the volatility of the Company's operating results and financial condition. These forward-looking statements involve known and unknown risks and uncertainties and are based on current expectations, assumptions, estimates, and projections about the Company and the industry. The Company undertakes no obligation to update forward-looking statements to reflect subsequent occurring events or circumstances or to changes in its expectations, except as may be required by law. Although the Company believes that the expectations expressed in these forward-looking statements are reasonable, management cannot assure the public that their expectations will turn out to be correct. Investors are cautioned that actual results may differ materially from the anticipated results.

To view the source version of this press release, please visit https://www.newsfilecorp.com/release/137718

Link:
JZZ Technologies, Inc. Adds 28 Million Healthcare Products Consumer Records to Its Active Lifestyle Media Marketing Database - Yahoo Finance

NorthStar Earth & Space

NorthStar Earth & Space

NorthStar Earth & Space (NorthStar) and Astroscale announce today, at the 2022 International Astronautical Congress (IAC) in Paris, that they are forming a strategic partnership to further support space sustainability by combining NorthStars precise space-based resident space object tracking with Astroscales enhanced spacecraft navigation and capture capability for on-orbit servicing.

Under this agreement, Astroscale and NorthStar will leverage their respective know-how, expertise, and unique services to highlight their shared commitment to space sustainability. Together, NorthStar and Astroscale will cooperate to demonstrate the benefits of combining precise In-Space Situational Awareness (ISSA) services to support reliable on-orbit servicing in low Earth orbit.

In 2023, NorthStar will launch the first commercial Space Situational Awareness service to deliver higher precision detection, tracking, and coverage for all near-Earth orbital regimes. NorthStars Space Information and Intelligence (Si2) services will serve all satellite operators to better manage their fleets, enhance spaceflight safety, and ensure space sustainability.

Astroscale is advancing its End-of-Life Services, most recently tested during its ELSA-d mission, which successfully magnetically captured its demonstration client spacecraft in August 2021. The latest ELSA-M servicer is in rapid development for launch in 2024 in partnership with OneWeb, the UK Space Agency and the European Space Agency. The state-of-the-art ELSA-M servicer will capture and retire multiple client spacecraft during a single mission. This collaboration will advance specific ISSA services required to support the tracking and capture of the Client spacecraft, as well as provide essential space-safety information about other space objects in orbit. Astroscale will endeavour to partner with NorthStar as a supplier of SSA services for future Astroscale missions.

NorthStar is proud to join forces with Astroscale as part of an essential community that is committed to advancing innovation and commercial services for space sustainability, said Stewart Bain, CEO & Founder of NorthStar Earth & Space. Combining NorthStars space-based coverage with Astroscales impressive on-orbit servicing capabilities is a very powerful response to immediate challenges in all near-Earth orbits

Were delighted to announce this partnership with NorthStar to develop our in-space situational awareness technology and data, said Nick Shave, Managing Director of Astroscale Ltd. We see an opportunity to enhance our spacecraft servicer and client satellite navigation & tracking capability with support from Northstars Space Information and Intelligence Services. Were keen to leverage our Rendezvous and Proximity Operations (RPO) and satellite capture expertise and advance our commercial on-orbit debris removal services with the benefit of both ground derived and in-space data. This is a great partnership that we look forward to harnessing with our forthcoming ELSA-M mission to clean up space and protect our orbital environment for future generations.

About NorthStarNorthStar seeks to empower humanity to preserve our planet through a unique Space and Earth information & intelligence platform using space-based sensors. NorthStar strives to help transform the way governments, industry and institutions assess risk, enforce regulations and make decisions to foster the sustainable development of our earth and space environment.

NorthStars unique space-based commercial Space Situational Awareness services address many of the critical and immediate challenges facing all satellite operators. Striving to see every object in every orbit, NorthStar will deliver more frequent and precise observations of resident space objects than any current system. Through a suite of high-speed decision quality information services derived from its unparalleled coverage, object custody, and enhanced predictive analytics NorthStar generates its Space Information & Intelligence services.

NorthStars investors comprise a global coalition of strategic partners, including Telesystem Space (a co-enterprise of the Sirois family office, Telesystem and the Rogers Family Trust of Canada), the Space Alliance of Europe (Thales Alenia Space and Telespazio), the Government of Quebec, the Government of Canada and the Luxembourg Future Fund. NorthStar Earth & Space head offices are located in Montral, Canada, its U.S. subsidiary, NorthStar Earth & Space Systems, Inc. is headquartered in McLean, Virginia and its European subsidiary, NorthStar Earth & Space Europe S. r.l. is headquartered in Luxembourg.

https://northstar-data.com/

About AstroscaleAstroscale is the first private company with a vision to secure the safe and sustainable development of space for the benefit of future generations, and the leading company dedicated to on-orbit servicing across all orbits.

Founded in 2013, Astroscale is developing innovative and scalable solutions across the spectrum of on-orbit servicing, including in-space situational awareness, end-of-life, and active debris removal and life extension, to create sustainable space systems and mitigate the growing and hazardous build-up of debris in space. Astroscale is also defining business cases and working with government and commercial stakeholders to develop norms, regulations, and incentives for the responsible use of space.

Headquartered in Japan, Astroscale has an international presence with subsidiaries in the United Kingdom, the United States, Israel, and Singapore.

Astroscale is a rapidly expanding venture company, working to advance safe and sustainable growth in space and solve a growing environmental concern.

Find out more at http://www.astroscale.com

The rest is here:
Astroscale and NorthStar Partner to Develop In-Space Technology to Support Space Sustainability - Space Ref

Proactive

Sydney, Sept. 16, 2022 (GLOBE NEWSWIRE) -- Proactive, provider of real-time news and video interviews on growth companies listed in Australia, has covered the following companies:

EQ Resources Ltd (ASX:EQR) has delivered a significant increase in its Mt Carbine ore reserve and a substantial decrease in strip ratio, which improves mine life extension potential for Australias only primary tungsten producer.Click here

Radiopharm Theranostics Ltd (ASX:RAD) shares were trading 9% higher intra-day, at 18 cents, after securing a rare paediatric disease (RPD) designation for its DUNP19 technology for treating osteosarcoma by the US Food & Drug Administration (FDA).Click here

West Wits Mining Ltd (ASX:WWI)s preliminary trade-off studies as part of the Witwatersrand Basin Project (WBP) Project 200 initiative have confirmed the merits of progressing to a further scoping study.Click here

SenSen Networks Ltd (ASX:SNS, OTCQB:SNNSF) has delivered accelerating growth over the 2022 financial year, with operating results reflecting continued investments to support the companys rapid, ongoing vertical and geographic expansion, according to a report by Edison Research.Click here

Anson Resources Ltd (ASX:ASN) has added $50 million to the coffer for its Paradox Lithium Project in Utah, USA after securing binding commitments from institutional and sophisticated investors for a single tranche placement.Click here

Nova Minerals Ltd (ASX:NVA, OTCQB:NVAAF) and its 37%-owned affiliate Snow Lake Lithium have completed a further 20,000 metres of drilling at the Snow Lake Lithium Project in Manitoba, Canada, tripling the amount of drilling data that can be leveraged for an upcoming resource upgrade.Click here

New Century Resources Ltd (ASX:NCZ) has enhanced its board and management skillset with the appointment of senior resource industry professional Robert Cooper as its new managing director and CEO.Click here

Ora Banda Mining Ltd (ASX:OBM) will lose Keith Jones as a member of its board of directors as he plans to retire at the end of the month after more than three years with the company.Click here

Galena Mining Ltd (ASX:G1A) has achieved 83% construction progress as of August 31, 2022 at its Abra Base Metals Mine, situated in the Gascoyne region of Western Australia.Click here

Antipa Minerals Ltd (ASX:AZY) will receive a further $1 million boost to its capital-raising exercise as major shareholder Newcrest Mining Ltd intends to exercise its top-up right to maintain its 9.9% shareholding in the mineral exploration company.Click here

Lanthanein Resources Ltd (ASX:LNR)'s maiden drill campaign at the Lyons rare earths project, which started this week, is partially complete.Click here

ioneer Ltd (ASX:INR, OTC:GSCCF) has successfully completed a Technology System Supply Agreement with Caterpillar, the worlds largest manufacturer of construction and mining equipment and a leader in developing autonomous technology.Click here

Euro Manganese Ltd (ASX:EMN, TSX-V:EMN, OTCQX:EUMNF) has now filed two important instruments in the development of its Chvaletice Manganese Project in the Czech Republic.Click here

Strickland Metals Ltd (ASX:STK) has secured $1.225 million in funding in this latest share purchase plan (SPP), taking the company a step closer to its capital raising goal of $7 million.Click here

Duke Exploration Ltd (ASX:DEX) has received final assays from the reverse circulation (RC) drilling program it started in February at its flagship Bundarra Project.Click here

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About Proactive

Proactive is a unique tech-enabled platform providing companies globally with a comprehensive investor engagement solution across their business lifecycle.

With six offices on three continents, Proactive works with innovative growth companies quoted on the worlds major stock exchanges, helping executives to engage intelligently with investors.

In 2020, Proactive featured in 809 million search results, our content was viewed over 165 million times and our readers spent over 10 million hours on our websites. Proactive has produced over 300,000 articles and 20,000 executive interviews since it was established in 2006.

For more information on how Proactive can help you make a difference, email us at action@proactiveinvestors.com

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Proactive news headlines including EQ Resources, Radiopharm Theranostics, West Wits Mining and SenSen Networks - Yahoo Finance

VANCOUVER, BCandTORONTO, Sept. 16, 2022 /PRNewswire/ - Agnico Eagle Mines Limited (TSX: AEM) (NYSE: AEM) ("Agnico Eagle") and Teck Resources Limited (TSX: TECK.A) (TSX: TECK.B) (NYSE: TECK) ("Teck") announced today that Agnico Eagle has agreed to subscribe for a 50% interest in Minas de San Nicols, S.A.P.I. de C.V. ("MSN"), a wholly-owned Teck subsidiary which owns the San Nicols copper-zinc development project located in Zacatecas, Mexico (the "Transaction"). As a result of the Transaction, Teck and Agnico Eagle will become 50/50 joint venture partners at San Nicols.

"San Nicols is a high-quality project, located in a leading mining jurisdiction, with high grades, extremely competitive capital intensity, and first quartile costs," said Don Lindsay, President and CEO of Teck. "The opportunity to add the operating and development experience of Agnico Eagle should generate substantial benefits for the project including for all stakeholders throughout the project life cycle."

"This is a unique opportunity to create a long-term partnership between two high quality mining companies working together to de-risk and optimize a world class VMS deposit in a premier mining jurisdiction," added Ammar Al-Joundi, President and CEO of Agnico Eagle. "Agnico Eagle's project development, permitting and construction experience in Mexico, combined with Teck's base metals expertise, operating excellence and marketing leadership, are complementary skillsets and will contribute to the timely and successful development and operation of San Nicols."

Transaction Highlights

San Nicols Project Highlights

San Nicols Study Status

A detailed plan to complete a feasibility study, permitting, and community engagement has been developed, with initial work underway since January 2022. Further, an environmental and social baseline survey, including in-depth archaeological surveys and clearances, was carried out by Teck from 2018 to 2021. Well-developed community engagement and investment programs have resulted in strong support for development from stakeholders near the project and more broadly in Zacatecas.

The feasibility study is expected to be completed early in 2024 with project sanction thereafter subject to receipt of permits.

About the Transaction

Agnico Eagle will subscribe for US$580 million in MSN shares, through a wholly-owned Mexican subsidiary of Agnico Eagle, giving Agnico Eagle a 50% interest in MSN. The subscription proceeds received from Agnico Eagle will be used by MSN to fund the first US$580million of post-closing costs with subsequent funding to be contributed according to each partner's ownership percentage. Agnico Eagle's contributions will be made as study and development costs are incurred there is no up-front payment from Agnico Eagle. The US$580million share subscription implies a notional US$290million acquisition cost to Agnico Eagle for 50% of the San Nicols project plus the contribution by Agnico Eagle of 50% of the first US$580million of project costs for its own account.

Funding requirements beyond this initial subscription amount will be funded by Teck and Agnico Eagle in proportion to their shareholdings in MSN. The shareholders' agreement will include provisions typical in a transaction of this nature, as well as remedies for material breach that include accelerated dilution and forced sale of a defaulting shareholder's ownership interest. For governance purposes, Agnico Eagle will be deemed a 50% shareholder of MSN from closing, regardless of the number of shares that have been issued to Agnico Eagle.

Closing of the Transaction is subject to customary conditions precedent, including receipt of necessary regulatory approvals, and is expected to occur in the first half of 2023.

Additional Information on the San Nicols Project

For further details on the San Nicols project, please refer to the Supplemental Information slides in the Investors section of Teck's website (https://www.teck.com/investors/events-&-presentations/presentations-webcasts/supplemental-information-for-investors).

About Teck

As one of Canada's leading mining companies, Teck is committed to responsible mining and mineral development with major business units focused on copper, zinc, and steelmaking coal, as well as investments in energy assets. Copper, zinc, and high-quality steelmaking coal are required for the transition to a low-carbon world. Headquartered in Vancouver, Canada, Teck's shares are listed on the Toronto Stock Exchange under the symbols TECK.A and TECK.B and the New York Stock Exchange under the symbol TECK. Learn more about Teck atwww.teck.comor follow@TeckResources.

About Agnico Eagle

Agnico Eagle is a senior Canadian gold mining company, producing precious metals from operations in Canada, Australia, Finland, and Mexico. It has a pipeline of high-quality exploration and development projects in these countries as well as in the United States and Colombia. Agnico Eagle is a partner of choice within the mining industry, recognized globally for its leading environmental, social and governance practices. The Company was founded in 1957 and has consistently created value for its shareholders, declaring a cash dividend every year since 1983.

Forward Looking Statements

This news release contains certain forward-looking statements within the meaning of the United States Private Securities Litigation Reform Act of 1995 and forward-looking information as defined in the Securities Act (Ontario). Forward-looking statements and information can be identified by statements that certain actions, events or results "could", "may", "might", "should", "will" or "would" be taken, occur or achieved. Forward-looking statements in this news release include statements regarding the expectation that the Transaction will close and the timing of closing; the expectation that the San Nicols project will be developed into production; the expected timing of first production; the estimated mine life; the expectation that there is meaningful mine life extension and regional exploration potential; the expected ownership interests of Teck and Agnico Eagle in the joint venture at any time; the expected production over the first five years of operation; all San Nicols project economics included in this news release, including head grades, average C1 operating costs, development capital cost estimate, payback period and IRR; the expectations as to results of the feasibility study, including development capital cost estimate, payback period and IRR; the statement that the project has been de-risked; and timing of project sanction decision.

Forward-looking statements involve known and unknown risks, uncertainties and other factors, which may cause the actual results, performance or achievements of Teck, Agnico Eagle or the joint venture to be materially different from any future results, performance or achievements expressed or implied by the forward-looking statements. Factors that may cause actual results to vary include, but are not limited to, changes in general economic conditions or commodity prices, unanticipated permitting, development or construction issues including delays in receiving permits or other regulatory approvals, or withdrawal or suspension of permits, unanticipated geotechnical conditions or other factors affecting construction plans and budgets including supplier, transportation, logistics or labour issues, adverse weather or natural disaster, community unrest, access issues, failure of plant and equipment, disruption of financial markets, the accuracy of our mineral estimates (including with respect to size, grade and recoverability) and the geological, operations and price assumptions on which these are based, other circumstances interfering with the closing of the Transaction, including an inability to satisfy the conditions to closing, including receipt of any regulatory approvals and failure by Teck or Agnico Eagle to fund as required by the agreements. Economic projections for the San Nicols project are presented on a 100% basis and, except as otherwise noted, assume US$3.50/lbcopper, US$1.15/lbzinc, US$1,550/oz gold, and US$20/oz silver.

Teck and Agnico Eagle caution you that the foregoing list of important factors and assumptions is not exhaustive. Other events or circumstances could cause actual results to differ materially from those estimated or implied by these forward-looking statements. Certain of these risks are described in more detail in the Annual Information Form of Teck and/or Agnico Eagle and in their respective subsequent quarterly report filings with Canadian securities administrators and the US Securities and Exchange Commission. Neither Teck nor Agnico Eagle assumes the obligation to revise or update these forward-looking statements after the date of this news release or to revise them to reflect the occurrence of future unanticipated events, except as maybe required under applicable securities laws.

SOURCE Agnico Eagle Mines Limited

Original post:
Teck and Agnico Eagle Announce Agreement on the San Nicols Copper-Zinc Project located in Zacatecas, Mexico - PR Newswire

Russias cutting-edge war machine, the MiG-31, capable of firing deadly hypersonic missiles, demonstrated its firing capabilities in the upper reaches of the atmosphere.

Russian Su-35 Fighter Demolished Ukrainian Air Defense Radar By Firing Anti-Radiation Missile, Moscow Says

Officials in the Russian Navys Baltic Fleet recently announced that Russian MiG-31 fighter jets practiced missile attacks during maneuvers in the stratosphere on September 13, Russian media Pravda reported. The Baltic fleet is headquartered at Kaliningrad.

The pilots of MiG-31 aircraft practiced flight maneuvers in the stratosphere, trained their skills to escape attacks from mock enemy aircraft and relocate to operational airfields of the region, said the statement from the Baltic Fleet.

In February, EurAsian Times reported that Russia had reportedly stationed a MiG-31K Foxhound fighter jet armed with a Kinzhal hypersonic land-attack missile in Kaliningrad along the Baltic Coast. The deployment was made days before the Russian troops launched their so-called special military operations.

Later, the Russian Ministry of Defense announced on August 18 the deployment of three MiG-31 fighters armed with Kinzhal hypersonic missiles to Chkalovsk airfield in the Kaliningrad Region as part of additional strategic deterrence measures.

According to reports, the three aircraft were moved to the Kaliningrad area for the exercises, where they simulated strikes on mock-up enemy command centers as part of training flights. The flights of the MiG-31 aircraft took place under the cover of Su-27 fighters.

It is pertinent to note that the Baltic region in Eastern Europe has seen hyper-vigilance from Moscow and the West in the aftermath of the invasion. When the Russian invasion began, the US sent its fighter jets to the Baltic for NATOs air policing missions.

MiG-31s are not frequently stationed at Russias Kaliningrad location. Some of the 50 aircraft stationed at the facility are older Su-27 and Su-24 fighters, with some newer Su-30SM and Su-35S jets on the way. According to reports, Iskander missiles are also housed in the enclave.

Besides the MiG-31 fighter jet, Russian reports indicated that the crews of the Eleron and Orlan-10 unmanned aerial vehicles of the Baltic Fleet practiced the tactics to overcome the air defense zone of a mock enemy at the Kaliningrad enclave.

While the MiG-31 drills are significant as they come during a surprising counter-offensive by Ukraine, it is not the first time this mighty warplane conducted exercises in the stratosphere. The MiG-31 had practiced in the stratosphere as early as 2017.

Further, in August 2019, the crews of upgraded MiG-31BM fighter jets held their first-ever dogfight in the stratosphere at an altitude of over 20 kilometers, as previously reported by TASS.

The two-seat MiG-31, known as the Foxhound under its NATO designation, is Russias primary fighter-interceptor aircraft. It has two D-30F6 engines, which help the aircraft have a base range of 1900 miles and a top speed of Mach 3 at high altitudes.

The MiG-31 is equipped with the SBI-16 Zaslon fixed phased array antenna radar, one of the most advanced in the world, to support its long-range and high-altitude air defense duty. The MiG-31 can engage air targets with various long and short-range missile combinations in addition to its Gsh-6-23 23mm gun.

The Russian Defense Ministry announced its plans to fund a MiG-31 Foxhound interceptor modernization and life extension program in July 2020. The MiG-31 can fly at high speeds and low altitudes, thanks to its sleek and aerodynamic body. The aircraft is built to track several targets at high altitudes simultaneously.

Despite Russias claims that it is developing the MiG-41 to replace the MiG-31, there is little evidence that the plane will be operational soon. Therefore, Russia has decided to develop several updated MiG-31 variants that will enable the Foxhound to continue service for many years. The MiG-31BM is the most notable of these.

The MiG-31BM is one of the MiG-31s most potent variants. It is a multipurpose, fast, long-range fighter with the power to destroy air and ground targets.

The MiG-31BM includes upgraded avionics, hands-on-throttle-and-stick (HOTAS) controls, liquid-crystal color multifunction displays (MFDs), a robust onboard computer system, digital data linkages, and phased array radar. It has the capability of intercepting 24 targets at once.

The MiG-31BM was initially intended to carry Kinzhal hypersonic missile, but MiG-31K was later selected as the carrier, according to Russian Defense Minister Sergei Shoigu. MiG-31Ks were used to strike targets early in Russias 2022 invasion of Ukraine with Kinzhals. Only 10 to 20 MiG-31Ks have beenupgradedto fire Kinzhals.

These Russian interceptor fighters have also intercepted NATO spy planes and fighter jets and will potentially continue to be deployed for a long time. In January,China-based Sohu publication had referred to the Russian MiG-31 interceptor fighter as a mysterious killer.

Read more:
Russias MiG-31 Fighter That Fired Hypersonic Missiles On Ukraine Conducted Drills In The Stratosphere - EurAsian Times

New York, Sept. 20, 2022 (GLOBE NEWSWIRE) -- Reportlinker.com announces the release of the report "Space In-Orbit Refueling Market - A Global and Regional Analysis: Focus on Application, End User, Capability, and Country - Analysis and Forecast, 2022-2032" - https://www.reportlinker.com/p06317753/?utm_source=GNW 8 million by 2032 at a compound annual growth rate (CAGR) of 103.85% during the forecast period 2022-2032 (CAGR:2026-2032). The major factor driving the market growth is expected to be the increase in demand for sustainable and reusable space systems.

With the increasing number of satellites going into space, the demand for satellite servicing has been rising.In the future years, refueling capabilities are expected to become a need rather than an option for satellite operators.

Several market players have already started demonstrations and some have been successful. Commercial players are expected to extract the maximum benefit of the space in-orbit refueling technologies.

Market Lifecycle Stage

Space in-orbit refueling has been on the wishlist of satellite operators for decades, however, even though the concepts existed, no company was able to materialize the technology.However, in the past 5 years, multiple established players and startups have entered the market and are now full-fledged working on the refueling capabilities.

Massive amounts of investments are pouring into the industry and multiple collaborations are happening in order to co-develop new technologies.

Over 15 years of research and development on satellite refueling technologies have bought us to a stage where key players are performing successful demonstrations of in-orbit refueling and services in-orbit.Additionally, commercial players with large constellation sizes or heavy communication satellites are expected to adopt the market first.

Following this, government agencies like NASA and ESA are also stepping forward to develop technologies and fund startups in the in-orbit refueling industry.

Applications, such as site earth observation, communication, and navigation, are some of the areas where satellites are expected to be refueled in the coming years. Moreover, newer technologies, such as advanced docking systems, fueling ports, and artificial intelligence software are expected to support the growth of the space in-orbit refueling market over the 2022-2032 forecast period.

Market Segmentation:Segmentation 1: by Application Earth Observation Communication Navigation

Based on application, the space in-orbit refueling market is expected to be dominated by the communication segment owing to its technological and economic feasibility. Communication and Earth observation applications are expected to see the first initial missions for refueling.

Segmentation 2: by End-User Commercial Other End Users

Based on end-user, the space in-orbit refueling market is expected to be dominated by commercial end-users.Commercial end-users are expected to garner significant share and growth due to their priority requirement and economic feasibility.

Commercial satellite operators with large satellite constellations and heavy communication satellites are expected to adopt the technologies faster compared to any other segment.

Segmentation 3: by Region North America Europe Asia-Pacific

During the forecast period, North America is expected to dominate the space in-orbit refueling market (by region).The significant presence of key companies engaged in developing space in-orbit refueling services is a major factor responsible for the regions growth.

A higher number of collaborations between various service providers, satellite operators, and enabling technology providers is another factor driving the market growth. An increasing number of start-ups and emerging players and successful demonstrations and increasing investments by key players in the market are also contributing to the market growth.

Recent Developments in the Space In-Orbit Refueling Market

In January 2022, Astroscale Holdings Inc. and Orbit Fab, Inc signed a commercial agreement for refueling LEXI in the GEO orbit. LEXI is the first satellite that is designed to be refueled. As per the agreement, Orbit Fab, Inc will refuel Astroscales fleet of LEXI Servicers with up to 1000 kgs of Xenon Propellant. To develop technologies for cryogenic propellant storage and transfer, with these awards, NASA is investing in technologies for the storage and transfer of cryogenic propellants in space. Four awards worth more than $250 million went to companies working on cryogenic fluid management. To demonstrate refueling a GEO satellite, Northrop Grummans Mission Extension Vehicle-1 (MEV-1) docked with Intelsat 901 on 25th February 2020 and pushed the satellite back to its normal orbit. Northrop Grummans MEVs are expected to give more than 15 years of life extension to these satellites along with providing spacecraft inspections, inclination changes, and orbit repair. In April 2022, Washingtons Defense Innovation Unit (DIU) is planning to provide commercial refilling services in near the prime space real estate of Geosynchronous Orbit, commonly referred to as GEO. Its also planning on creating a bulk fuel depot in the orbits. DIU is looking for companies with the capability for bulk liquid and gas propellant storage (>5,000 kg) in orbit. Two of the propellants include hydrazine and liquid oxygen. In April 2022, Orbit Fab, Inc and Neutron Star Systems have announced a partnership for the co-development of sustainable propulsion capability and satellite refueling technologies. The agreement will help to increase the range of refuellable propellants by combining NSS propellant-agnostic electric propulsion technology with Orbit Fabs refueling interfaces and tankers.

Demand - Drivers and Limitations

Following are the drivers for the Space In-Orbit Refueling market: Increase in Demand for Sustainable and Reusable Space Systems Life Extension Services to Enable Other In-Orbit Services in Future

Following are the challenges for the Space In-Orbit Refueling market: High Operational Cost of Refueling Interface and Docking Regulatory Challenges Spacecraft Design Compatibility for Refueling Operations Storage and Transfer of Cryogenic Propellants in Space

Following are the opportunities for the Space In-Orbit Refueling market: Increase in Investments for Startups Rise in Demand for In-Space Services Advancement of New Space Technologies for Storage, Refueling, and Receiving Propellants

How can this report add value to an organization?

Product/Innovation Strategy: The product section will help the reader understand the different solutions for the space in-orbit refueling and services market, such as the type of capabilities and emerging technologies.It will also help readers understand the potential of the services at a global level and learn about their progress.

The players operating in these markets are developing innovative offerings and are deeply engaged in long-term agreements and contracts with commercial and government agencies. Moreover, the study also examines the investment scenario in the space in-orbit refueling and services market.

Growth/Marketing Strategy: The players operating in the space in-orbit refueling market are engaged in several strategies, including strategic partnerships, contracts, agreements, and business expansion. The marketing strategies will help the readers understand the revenue-generating strategies adopted by the in-orbit service providers operating in the space in-orbit refueling market.

For instance, Orbit Fab, Inc and the U.S. Air Force Research Laboratory have signed a technology-sharing agreement to share details regarding RAFTI. The company markets its products to all different layers of the military, intelligence, and commercial satellite community. The Air Force will help Orbit Fab review some of the technologies that aided in developing them. More specifically, they are going to advise on requirements and design elements, as well as provide testing and qualification access at several governmental facilities throughout the country.

In February 2022, Northrop Grumman-owned SpaceLogictics has signed a launch agreement with SpaceX and a contract with Optus for the sale of its Mission extension pod. Under the agreement, SpaceX will be responsible for providing launch services for the 2024 MRV and MEP launches.

Competitive Strategy: The study has analyzed and profiled the key service providers, start-ups, and emerging players in the space in-orbit refueling market.These companies capture the maximum share in the global space in-orbit refueling market.

Additionally, a detailed competitive benchmarking of the companies and organizations operating in the space in-orbit refueling market has been carried out, which will help the reader to understand the performance of the players, exhibiting a clear market landscape. In addition to this, comprehensive competitive strategies such as partnerships, agreements, and collaborations will aid the reader in understanding the potential revenue opportunities in the market.

Key Market Players and Competition Synopsis

The companies profiled in the study have been selected based on inputs gathered from primary experts and analysis of the companies product portfolios, key developments, and market penetration.

Space in-orbit refueling as a technology is still in the development and demonstration phase.However, there are several established players and startups that have entered the market and have made considerable progress.

Considering the present market scenario and future forecasts, the market is expected to grow at a CAGR of 103.85% by 2032.

Some prominent established names in this market are: Astroscale Holdings Inc. Altius Space Machines, Inc. D-Orbit SpA Lockheed Martin Corporation LMO Space Maxar Technologies Inc. Momentus Space Orbit Fab, Inc. Obruta Space Solutions Orbit Recycling SpaceX SpaceLogistics (a subsidiary of Northrop Grumman Corporation) Space Machines Company Starfish Space Inc. Tethers Unlimited, Inc.

Countries Covered North America U.S. Canada Europe Germany Russia France U.K. Rest-of-Europe Asia-Pacific India Japan Rest-of-Asia-PacificRead the full report: https://www.reportlinker.com/p06317753/?utm_source=GNW

About ReportlinkerReportLinker is an award-winning market research solution. Reportlinker finds and organizes the latest industry data so you get all the market research you need - instantly, in one place.

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Originally posted here:
Space In-Orbit Refueling Market - A Global and Regional Analysis: Focus on Application, End User, Capability, and Country - Analysis and Forecast,...

On August 28, the United States sent two Ticonderoga-class guided-missile cruisers through the Taiwan Strait, the first such freedom-of-navigation mission since House Speaker Nancy Pelosis visit to Taiwan was met by a large-scale show of force by China. Beijing, of course, protested the sailing. On June 13, the Chinese foreign ministry declared, There is no such thing as international waters in international maritime law. Beijing claims that Taiwan is a renegade province, thus making all the waters between it and the mainland an internal waterway.

The United States usually only sends one warship at a time, a destroyer. Sending both the USS Antietam and USS Chancellorsville, the largest surface warships in the fleet except for aircraft carriers was meant to be a strong demonstration of resolve in the wake of Beijings live-fire exercises around the self-governing island. Chinas state media, however, tried to downplay this, arguing the US is fully aware of and fear of the PLA's capability so that it needs two warships to accompany with each other to embolden themselves But the Ticonderoga-class cruiser is a very old warship, and the PLA's Type 055 is much more advanced. Beijing is also aware that nine Ticonderoga-class ships are slated to be decommissioned. The USS Vella Gulf was in fact taken out of service three weeks before its sister ships sailed through the Taiwan Strait. It had served only twenty-nine years out of its designed thirty-five-year lifespan.

The Navy has tried to justify retiring the cruiser force early because it costs more to maintain older ships, putting a strain on maintenance funding and the capacity of the ship repair industry. Seven of the cruisers are in some phase of a service-life extension and modernization program, which is requiring significant manpower at repair yards, running years late, and costing more than the service budgeted for. Theyre eating us alive in terms of our ability to get maintenance back on track, which is where we need to be, Chief of Naval Operations Adm. Mike Gilday told a recent conference.

So, the real problem is an inadequate naval industrial base to support a fleet large enough to carry out its global missions and meet the challenge of a fast-growing Chinese navy that seeks to control the Pacific Rim. At risk are the territories and trade of every nation in the region, not just Taiwan. The collapse of the American commercial shipbuilding industry decades ago denies the U.S. Navy mobilization capacity, whereas China has created the largest shipbuilding industry in the world.

The most cited target number for the size of the Navy comes from its 2016 goal of 355 manned ships. Of these, only 104 were Large surface combatants (cruisers and destroyers), which at the time included the Ticonderoga-class cruisers. The Navy currently has 300 battle force ships (up from a low of 279 in 2007, which was less than half as many as at the end of the Cold War). In April, the Navy issued a new plan with alternatives based on funding. Under Alternative 1, the Navy would have 300 manned ships in 2035 and grow to 316 manned ships by fiscal year (FY) 2052. Under Alternative 2, the Navy would have 300 manned ships in 2035 and grow to 327 manned ships by FY2052. These two options assume no real increase in funding. Under Alternative 3, which hopes for a very modest 3-5 percent real growth in funding, the Navy would still have 300 manned ships in 2033 but would grow to 367 manned ships by FY2052. These figures do not provide much solace for those who believe there will be crises in the Indo-Pacific involving China well before 2035.

According to the recently released Chief of Naval Operations Naval Plan 2022, To simultaneously modernize and grow the capacity of our fleet, the Navy will require 3-5% sustained budget growth above actual inflation. Short of that, we will prioritize modernization over preserving force structure. This will decrease the size of the fleet until we can deploy smaller, more cost-effective, and more autonomous force packages at scale. The Nation cannot afford to cede influence to China or Russia. Nor can it afford to lose combat credibility. And that decrease already calls for decommissioning of twenty-four ships in the FY2023 budget, more than just the cruisers. The autonomous force packages will be unmanned vehicles, some with significant firepower, but they will not begin to join the fleet until after 2027.

The Navy has estimated to Congress that expanding the fleet even at the modest pace of Alternative 3, would require an additional $13 billion per year to build, man, and operate a larger fleet. When President Biden issues an Executive Order canceling $300 billion or more in student loans, after enacting a series of spending bills amounting to some $3.8 trillion in additional spending for pandemic recovery, infrastructure, green industry development, and other projects, the Navys request seems hardly noticeable. Yet its legislative prospects are uncertain despite the bipartisan consensus on the China threat.

Warships are not just procured; they need to be built, which brings the industrial base back to the center of discussion. In 2019, I wrote a piece for the U.S. Naval Institute that went beyond concern for backlogs in repair and maintenance to point out that there was no excess capacity to handle battle damage if the Navy actually had to engage in sea battles for the first time since World War II. None of these problems have been remedied in the years since and there is even now a question of whether a larger fleet can be built, let alone maintained.

On August 25, Admiral Gilday stated that We have an industrial capacity thats limited. In other words, we can only get so many ships off the production line a year. My goal would be to optimize those production lines for destroyers, for frigates, for amphibious ships, for the light amphibious ships, for supply ships. Gilday noted that he wanted to produce three destroyers and two or three submarines a year, but there are doubts that there is room for a third destroyer or submarine at U.S. shipyards. This is not a new problem. Much work was done in 2017 calling for new investment in shipyard capacity for construction and maintenance. Human capital is also needed as the shipyard workforce is aging. Shortages in skilled labor are an economy-wide problem but deserve special public attention when it impacts national security.

Newport News Shipbuilding and Virginia Peninsula Community College have teamed up to offer a program to foster solid careers in a strategic field that can provide satisfaction beyond a paycheck. More such programs should follow across the country as the supply chains for the defense industry are national. Yet, even if the needed increases in training, innovation, and funding are forthcoming, it will take years to send more warships to sea.

This is why it seems so risky to decommission major warships when short-term dangers loom. Beijing is watching closely for a moment when the balance of power in the Indo-Pacific shifts enough to offer an opportunity to strike. Peace depends on deterrence and deterrence depends on the capabilities that exist each day, not a decade or two from now. The Ticonderoga-class cruisers may not be the most modern warships but they still pack a punch with 122 missile cells plus additional launchers for Harpoon anti-ship missiles and torpedoes. Its Aegis radar needs an upgrade but is still better than most of what anyone else has afloat. Best of all, it exists and can hold the line until something better comes along to take its place rather than leave a void the Chinese will try to exploit.

William R. Hawkins is a former economics professor who served on the professional staff of the U.S. House Foreign Affairs Committee. He has written widely on international economics and national security issues for both professional and popular publications.

Image: Flickr/U.S. Navy.

Read the original post:
Build to Deter: The Navy Needs More Ships to Take on China - The National Interest Online

Spacecraft running low on fuel could get a refill from an orbital station by the year 2025, according to a startup named Orbit Fab that reckons it can charge $20 million to top up your tank.

The American upstart believes there's a market for its planned service because the growing number of companies launching satellites want their hardware to have longer working lives. One way to achieve lengthier missions is orbital refueling.

Orbit Fab is therefore hoping to build, for want of a better word, a depot 300 km from Earth in geostationary orbit that can send out shuttles each containing, say, 100kg of hydrazine to visiting satellites and potentially other spacecraft that need a refill and can plug into the tanks.

And suitably capable spacecraft could dock with the depot to pick up fuel for themselves or to take to satellites and other craft, SpaceNews reported.

Orbit Fab's rendering of its refueling station ... Click to enlarge

Co-founder and chief development officer Jeremy Schiel said government agencies and private operators have "expressed explicit interest to get refueled in the next three to five years." He also said that the design of the fuel depot system is "basically done," and that the company is now working on designing its fuel shuttles.

"It's much easier to come up with a price for GEO [geostationary orbits] because it's one orbit," Schiel explained. "You're going to have to have a different price point on each different orbit in low earth orbit because of how you're going to get there. We're tackling the easy commercial price of GEO first and then we'll start working our way down."

Astroscale, an orbital debris removal biz, is the only customer that has publicly signed up for the satellite refueling service. Orbit Fab has committed to supplying 1,000 kilograms of xenon propellant to top up Astroscale's Life Extension In-Orbit (LEXI) satellites, which are capable of being refueled in space and are scheduled to launch in 2026 into geostationary orbit.

These satellites, and other future craft, need to include Orbit Fab's Rapidly Attachable Fluid Transfer Interface (RAFTI) ports that the fuel shuttles will use to top up visiting craft.

Spacecraft in geostationary orbits today won't have RAFTI ports, and Orbit Fab will need to come up with another method of refueling them. Schiel said the startup will have to rely on third-party vehicles that are compatible with what's already in space as well as Orbit Fab's hardware, such servicing spacecraft built by Northrop Grumman or Astroscale.

"They can go service the legacy satellites and we can service the servicing vehicles that are coming online," Schiel said. "Eventually, when everyone's flying a RAFTI fueling port, we can start going directly to them."

The Register has sought further comment from Orbit Fab.

See original here:
Startup wants to build a space station that refuels satellites by 2025 - The Register

A 4.2 million refurbishment scheme will refurbish or renew mechanical and electrical components in Dunball Sluice. This sluice controls flood flows in the Kings Sedgemoor Drain (KSD) and the River Sowy, which is also known as the River Parrett Flood Relief Channel.

Dunball Sluice is a critical structure in the defence of the Somerset Levels and Moors and became operational in 1971. It sits at the location where the Kings Sedgemoor Drain (KSD) meets the tidal River Parrett. 4 gated culverts control water levels by releasing water into the Parrett when the tide permits while preventing the tide from bringing saltwater into the KSD. This would impact nationally and internationally designated freshwater habitats.

The refurbishment will also make environmental improvements to encourage the migration of eels and improve access for otters between the KSD and the River Parrett. Health and safety improvements for Environment Agency staff and contractors who operate and maintain the sluice will also be completed as part of the scheme.

Rachel Burden of the Environment Agency said:

The project will extend the life of Dunball Sluice. Reducing the potential for failure and mitigate the risk of flooding to properties and internationally and nationally important freshwater habitats.

The scheme, funded by the Department for Environment, Food and Rural Affairs (Defra) with 650,000 partnership funding provided by Somerset Rivers Authority. The scheme will begin at the end of July 2022 and is programmed to be completed by 2024.

Work begins on creating Dunball Sluice which opened in 1971

Cllr Mike Stanton, Chair of Somerset Rivers Authority (SRA), said:

Im delighted that the SRA is helping to make this work possible. Dunball Sluice is a crucial facility. Refurbishing it boosts the SRAs own major scheme to increase the floodwater-carrying capacity of the River Sowy and Kings Sedgemoor Drain.

Sowy-KSD works are being delivered for the SRA by the Environment Agency up until the end of October. As partners were working together to reduce flood risks across a large part of the Somerset Levels and Moors.

The work will not have an impact on the continuing operation of the sluice and all refurbishment works will be undertaken within the compound area.

If there is a need to move water out of the system into the Parrett but the tidal gates cant be used due to the state of the tide. Then temporary pumps can be set up at the sluice to pump water over the structure and into the river. This was last done in 2014 and upgrades have been made since to better accommodate temporary pumps deployed from the nearby Bradney depot.

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Dunball Sluice to get 25 year life extension - GOV.UK

Researchers report that when young and old mice were surgically joined such that they shared blood circulation for three months the old mice did not significantly benefit in terms of lifespan. In contrast, the young mice that were exposed to blood from old animals had significantly decreased lifespan compared to mice that shared blood with other young mice.

The study Three Month Heterochronic Parabiosis Has a Deleterious Effect on the Lifespan of Young Animals, Without a Positive Effect for Old Animals appears in Rejuvenation Research, published by Mary Ann Liebert, Inc.

Our previous study showed that an exchange of blood between heterochronic parabionts for 3 months did not rejuvenate the immune system of the old partners. Moreover, the young immune system became more aged and began to function according to the old principle. Does this forced aging affect all systems of the organism in this model, write the investigators.

We checked the levels of corticosterone, testosterone, insulin-like growth factor 1 (IGF-1), insulin, and thyroxine in the blood of heterochronic parabionts, but did not find significant changes compared with age-related controls. Since numerous data support the possibility of rejuvenation of the brain, muscles, and other tissues using the model of heterochronic parabiosis, as well as opposite data, we planned to assess the overall effect of this long-term blood exchange on the rate of organism aging.

We measured the life span of animals whose blood was exchanged for 3 months and then were disconnected. Median and maximum life expectancy decreased in young heterochronic parabionts compared with the isochronic control. Old heterochronic parabionts showed only a small trend toward an increase in the median life span, but it was not statistically significant, and the maximum life span did not change compared with the isochronic parabionts.

These data support our assumption that old blood contains factors capable of inducing aging in young animals. The mechanism of selective suppression of aging factor production in the organism could be a key research field for life extension.

Heterochronic parabiosis is a research tool used to assess the effect of organs and of blood-borne factors on young and old animals. Less controlled than direct blood exchange, parabiosis is a model of blood sharing between two surgically connected animals.

Iryna Pishel, from Kyiv National Taras Shevchenko University and Bienta Ltd. in Kyiv, Ukraine, where she serves as head of laboratory applied pharmacology, and coauthors used heterochronic parabiosis between young and old mice and the isochronic controls for three months. They then disconnected the animals and studied the effects of being joined on the blood plasma and animal lifespan.

The most robust and interesting result of this study is the fact of a significant decrease in the lifespan of young mice from heterochronic parabiotic pairs, say the scientists. These data support our assumption that old blood contains factors capable of inducing aging in young animals. Finding and selective suppression of aging factor production in the organism could be the key research field for life extension.

This work clarifies the question whether the young blood or old blood controls longevity, which has been debated [for some time]. Are there lasting effects of heterochronic parabiosis and if so, is it a rejuvenation or aging? The work by the Pishel group established that thelifespanof the old mice does not increase after being parabiosed to young mice. In contrast, the young animals that were joined with the old mice suffer a shortened lifespan, even after being disconnected, noted Irina Conboy, PhD, professor, college of engineering, University of California, Berkeley, and editor-in-chief of Rejuvenation Research.

This discovery is important in establishing the accurate direction for clinical anti-aging approaches and in providing key scientific evidence against the potency of the young blood factors in an aged organism. This work neatly follows the previously published by this group report that infusions of young blood plasma into mice, does not increase their lifespan.

On an important note, Pishel conducted these seminal studies as the head of the department at Kyiv National Taras Shevchenko University, yet composed the paper as a refugee, from data collected before the outbreak of war. Such important studies were interrupted by the war, and it is hoped that they will soon continue and yield more breakthroughs.

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Old Blood Found to Contain Factors That Induce Aging in Young Animals - Genetic Engineering & Biotechnology News

HOUSTON, Aug. 9, 2022 /PRNewswire/ -- RESA Power, LLC, a market leader in power systems electrical testing, transformer services and life extension solutions for power distribution equipment, has announced the acquisition of Advanced Electrical Services, Ltd.

Based in Alberta, Canada, Advanced Electrical Services (AES) is a NETA accredited company that has two locations in Calgary and Edmonton from which it has been providing electrical testing services since 2008 throughout Western Canada. AES specializes in providing medium and high voltage services and products into the renewable energy, mining, commercial, utility, and oil & gas market segments in Western Canada. RESA Power was acquired by Investcorp, a leading global alternative investment firm, in December 2021 and this marks the first add-on acquisition under their ownership.

Mark Angus, Chief Growth Officer at RESA Power, commented on the acquisition, "RESA Power has worked closely with the team at AES for several years and successfully collaborated on many projects, both in the USA and Canada. This long history of teamwork has deepened the relationship between RESA and AES to the point where this was the next logical step for both companies. Kevin Noonan, Zak Houk, Mark MacHattie, and the rest of the AES team have built a high-quality business that has earned the trust and respect of many customers who operate in the Western Canada marketplace. We view this alliance as providing a robust platform, along with our existing RESA business in Vancouver, to broaden our reach into the Canadian marketplace as well as adding an impressive roster of 30+ highly skilled technicians to the 200+ field technicians already in the RESA Power family."

Kevin Noonan, President, and co-owner of Advanced Electrical Services, added, "We are delighted to formally partner with RESA Power, and feel that our combined expertise and resources will enable us to provide our existing customers not only an enhanced portfolio of products and services, but also broaden our geographic reach, enabling us to meet our customers' requests to service more of their locations from a local base of operations. Additionally, we look forward to partnering with RESA Power on larger projects in both Canada and the USA."

About RESA Power, LLC

RESA Power, a portfolio company of Investcorp, a global alternative investment firm, is a market leader in power systems services and life extension solutions for power distribution equipment used in mission critical environments. With locations across the United States and Canada, RESA Power is uniquely capable of ensuring our customers' critical power systems are safe, reliable, and operating at peak efficiency. The technicians and engineers at RESA Power are experts in testing and servicing transformers, relays, breakers and other key components of power distribution and control systems. RESA Power also provides quick turn-around custom manufactured or retrofit switchgear and breaker solutions and maintains an extensive inventory of obsolete and hard-to-find components. For more information about how to join the RESA Power group, visit http://www.resapower.com or follow us @RESAPower on LinkedIn

Media Contact:RESA PowerJulia BaranavaMarketing Manager832-900-8343342079@email4pr.com

Cision

View original content to download multimedia:https://www.prnewswire.com/news-releases/resa-power-bolsters-its-presence-in-canada-with-the-acquisition-of-advanced-electrical-services-ltd-301601587.html

SOURCE RESA Power

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RESA Power Bolsters Its Presence in Canada With the Acquisition of Advanced Electrical Services, Ltd. - Yahoo Finance

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Much of the anti-aging focus isnt about radical life extension or ageless bodies, but rather about dodging the bad stuff until the final years of life

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Aging is getting so old.

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Paul McCartney, who turned 80 in June, likes to cap his workouts by balancing on his head, feet in the air, for five minutes and credits yoga ocular exercises (look up, centre, down, diagonally, and then around and around) for keeping his eyesight sharp.

Gloria Steinem, 88, is offering American women seeking abortions the guest room in her Manhattan home. Dont agonize. Organize, the feminist icon told pro-choice supporters after the overturning of Roe v. Wade. Harrison Ford, who turned 80 in July, has a fifth Indiana Jones film scheduled for release next year. Beloved British actor Patrick Stewart, 82, who shares a birthday with Ford, recently wrapped up shooting season three of his series Star Trek: Picard and was still rocking a toned midsection and biceps at 75. I dream of Jeannie star Barbara Eden (91 in August) does resistance training and eats like a carnivore. I like steak.

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In Canada, Jean Chrtien, 88, is funny and sharp as ever and recently scored as the most popular prime minister in modern Canadian history. Gordon Lightfoot, 83, who has a piece of steel and 10 pins in his right wrist after fracturing the joint last fall is among the scheduled headliners at this summers Canadian National Exhibition in Toronto. None of us is getting any younger, the legendary octogenarian singer-songwriter told the Toronto Sun last fall. Were all aware of that. And if we can be doing it, we might as well be doing it.

And, yeah, theyre doing it. Eighty is the new 60, or so the buzzy trope goes. The extension of life is one of the great medical and social miracles of the last century. Life expectancy in Canada in the year 1900 was 51. When parliament passed the Medical Care Act in 1966, men could expect to see their high 60s, women 75. Were now sitting at just under 80 for men, and 84 for women. Nearly one in five of us are 65 or older. Centenarians, the 100 and older, are the fastest-growing age demographic in the country.

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Its the triumph of aging, said Dr. Samir Sinha, director of geriatrics at Mount Sinai and the University Health Network hospitals in Toronto. Were seeing lots more people, an incredible number, who are living at much older ages and surviving to those ages in relatively good health.

Its true that people who make it to 100 and beyond dont necessarily make it there in perfect health; half will be living with some form of cognitive impairment, though they do manage problems like heart troubles or stroke remarkably well. And yes, people are living longer, but not universally or uniformly so.

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Its largely a benefit of the rich and the middle class, said bioethicist Arthur Caplan. In some countries, if you make it to 50 youre lucky. The poor do not live longer, said Caplan, head of medical ethics at NYU Grossman School of Medicine. Almost eight million adults in Canada are obese. Moderate obesity takes, on average, three years off a persons life. Severe obesity, 10 years.

Women generally outlive men. Those kinds of demographics get lost in the 80 is the new 60 buzz, Caplan said. Are you getting first-rate health care? Do you have access to a good, varied, nutritious diet? Do you exercise? Are you in a situation where theres not a lot of stress and worry?

There are hints about whats going on diet, decent health care, more healthy habits, more years in school, it helps to be rich that dont involve any big mysteries.

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Fewer children dying from infant infections and diseases, more women surviving childbirth, sanitation, vaccines, antibiotics, surgeries, earlier and better management of high blood pressure and coronary artery disease and strides in cancer care also brought us here. In the 60s and 70s we started realizing smoking was really bad for you, said Dr. Thomas Perls, director of the large and long-running New England Centenarian Study. Make it to 65 in Canada today, and you can expect about 20 years of life expectancy ahead of you, Sinha said. The good news is fewer numbers of those extra years are going to be spent in poor health. Things that would have killed us decades ago like a heart attack or stroke now Ive had people whove had multiple heart attacks and strokes and are still ticking along and youre like, wow, because of the advent of medical science.

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Dementia is among the most dreaded diseases of the old. But because of efforts to identify and modify risk factors like high blood pressure and elevated cholesterol we actually have fewer people living with dementia today than we thought wed have 10 or 20 years ago, Sinha said.

Much of the anti-aging focus isnt about radical life extension or ageless bodies envisioned by immortalists, but rather about compressing morbidity, dodging the bad stuff until the final years of life and slowing the onset of age-related dysfunction, so that people live well, and then die suddenly. Youre here, and then youre not.

The oldest human on record is Jeanne Calment, a French woman who died at age 122 in 1997 and who was still riding a bike at 100 and chain-smoking until the age of 117. A Japanese woman, Kana Tanaka, died in April, aged 119. She was chatty, liked soft drinks and board games and worked until she was 103.

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In the aging and longevity spheres, many millions are being sunk into regenerative medicine using cell-based therapies to reprogram cells and wind them back to more youthful states to repair or replace damaged tissue, from battered joint cartilage to scarred heart muscle. Researchers are testing the potential of metformin, the most widely prescribed anti-diabetes drug in the world, and other senolytic drugs to clear out undead senescent cells, so-called zombie cells that are haggard and old and have stopped proliferating but that refuse to die off. Instead, they loiter, oozing inflammatory molecules that drive age-related damage to tissues throughout the body.

Another movement is to push out the lifespan through genetic enhancement, finding ways to manipulate or mimic survival genes that increase longevity. Forget the free radicals and lets all pop antioxidants theory, says Harvard molecular biologist David Sinclair. We have the technology, Im telling you today, to be able to go into our hundreds without worrying about getting cancer in your 70s, heart disease in your 80s, and Alzheimers in your 90s, Sinclair told a recent 2022 Life Itself conference. This is the world thats coming. Its not really a question of if. Its literally a question of when. And for most of us, its gonna happen in our lifetime.

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Why do we even age? Sinclair uses an analogy about a nicked compact disc to explain what he calls his information theory of aging. Were not so much losing the digital music in the cell, the genes, he said, but the epigenetic information, the systems in the body that read the DNA, and tell genes whether to switch on or off. A skin cell doesnt want to turn on the same genes as a brain cell. That would be a problem. Genes that arent needed are bundled up. But, like a scratched up CD, the epigenome get messed up over time from DNA damage, and those bundles start to unravel. Genes that should be switched on get turned off, and vice versa. Cells lose their identity and function, Sinclair told his audience. That is why we age, why we get sick and why most of us die. His team is working on a way to polish the CD to get cells working properly again and reverse age-related diseases like glaucoma. In one experiment, they made blind mice see again.

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Inflammaging, or inflamm-aging, a chronic, low-grade inflammation that accumulates over time through diet, infections and environmental exposures, has also been implicated. Still, theres no one, tidy biological mechanism to explain biological aging, said Parminder Raina, a professor at McMaster University and lead principal investigator of the Canadian Longitudinal Study on Aging. His team has a new paper, not yet published but under review, that found people with early childhood adversity sexual, physical, or emotional abuse, parental conflicts age faster. They have faster epigenetic clocks than kids who werent exposed to those traumas.

We need to understand what normal aging looks like. Once we understand that, it might give us some sense of what early interventions might help, said Raina who, at 62, is in better physical shape than he was in his 30s.

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In some countries, if you make it to 50 you're lucky

He jogs, runs, walks, swims, eats healthy, plays golf. Social engagement is important to him. But he doesnt like the 80 is the new fill in the blank. It implies a certain level of ageism. Theres a tremendous amount of heterogeneity in the way we age, he says. Some age well, despite challenges, others, free of disease, not so well. Having a sense of purpose is critical. Loss of purpose is a deadly phenomenon, Raina said. Above everything else if we can get people to think about how they live, how they engage, how they participate in their communities, what creates purpose, that will take us a longer way on the healthy lifespan path than any drug or medication or biological pathway discoveries will ever do.

The human body is like any machine. It has wear and tear with time, no matter what we do. And that is going to catch up.

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Our life expectancy isnt increasing as fast as it once did. There are more centenarians. But, on average, we arent becoming 90-year-olds as rapidly as we saw earlier in the last 20, 30 years, Raina said. COVID-19 already has cut the life expectancy in dozens of countries. In Canada, deaths due to COVID reduced life expectancy at birth by about half a year in 2020, dropping it to what it was six years earlier.

Without some form of physiological or genetic engineering, Caplan pegs the upper limit at about 110 to 115 years max. But one recent paper set the fundamental or absolute limit of the human lifespan at 120 to 150 years, at which point the body simply runs out of resilience. For now, how to live longer and healthier comes down to the basics. The biggest contributor to a rather aptly named molecule known as GrimAge acceleration thought to drive a range of age-related disease is smoking, while a healthy diet has an inverse effect.

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In a recent virtual chat, Perls appealed to his centenarians and their families to send his team samples of their feces. Perls thinks its a pretty sure bet that different populations of bacteria in the gut and the substances those bacteria produce are playing a role in slowing or accelerating aging.

Some of his centenarians are also being asked if they might be willing to donate their brains upon death. Perls explained that the brain is removed at the funeral home, then quickly transported to a brain pathology lab at UCLA where a huge amount of study is performed to try to understand, for example, why the person, when alive, had zero signs of cognitive impairment, but had evidence of Alzheimers disease at autopsy. We call those people resistant, and we want to find out how resistance happens. Understand those biological mechanisms, and it may be possible to develop a strategy or drug to slow down the progression of the big ones, like Alzheimers, stroke, heart disease, diabetes and even some cancers.

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With age the brain shrinks in volume by one to two per cent a year. Others are showing how exercise reduces inflammation in the brain and induces the birth of new neurons in the hippocampus, the area involved in memory. Resistance training seems to have the biggest impact on cognitive function for older adults.

Why isnt entirely clear, but it seems resistance training is more mentally taxing. It includes a cognitive component, said Lindsay Nagamatsu an assistant professor at Western University. Learning to use new machines and the proper form, keeping track of weight loads and reps. Its more of a mentally stimulating activity compared to aerobic training.

On average, we arent becoming 90-year-olds as rapidly as we saw earlier in the last 20, 30 years

What else is good for the brain? A Mediterranean style diet, Nagamatsu said, so a lot of fish and nuts. Alcohol in moderation. Anything that increases inflammation obesity, heart disease, diabetes will affect the brain and increase the risk of dementia. Humans have evolved to the point that, rather remarkably, most of us should be able to live to about age 90, provided we dont squander our bodies, Pearls said in an interview with National Post. Average life expectancies are less than 90 years, and I think thats because people are taking their bodies for granted and can do some pretty harmful things, whether that be smoking or being obese or not getting enough sleep.

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Pearls also thinks avoiding, or at least limiting, red meat is a good idea. Sinclairs tips for keeping body and mind in optimal shape include exercising between 10 to 30 minutes three times a week at an intensity that causes you to pant, a little fasting (he eats one main meal a day) and good sleep. Personality traits also seem to matter. Centenarians tend not to be neurotic they tend not to worry about things they cant change, which presumably translates to lower stress, Boston University centenarian researcher Stacy Andersen said on the virtual update with Perls and high in extroversion.

Most, about 90 per cent, are disability free up to their early to mid-90s. It doesnt mean no diseases, ever, along the way, he said. But they have a history of managing these problems much, much better. The goal is about how to age better, which is different from aging longer, Caplan said. For many, their worst nightmare would be living a lot longer but with a devastating brain disease like Alzheimers or Lewy body dementia.

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But neither should older people be considered dependent beings past their due dates. Older workers could be one solution to Canadas labour shortage. We are starting to realize, why are we pushing people out the door at 65? We can probably get another five, 10 good years out of people, Sinha said.

There are some grumblings about inter-generational tensions, that younger people will be denied jobs or advancements if they have to wait for older people to get out of the way. But countries with aging populations like Canada have low unemployment rates relative to younger populations, Raina said, because older people create wealth.

He and others said we need new ways of thinking about policies and social programs, like old age pensions. We assume everybody over 65 is declining. Thats not the case. It is a way more heterogeneous population than their kids.

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But how old is too old to keep working? U.S. President Joe Biden, who turns 80 in November, is showing signs of frailty and loss of energy, said Caplan, even though hes not cognitively limited, and people, I think, politically want a dynamic leader. Part of Donald Trumps magic was that he could come off as dynamic, energetic, and tireless, Caplan said, even though he was obese and taking a nap all the time.

Age is going to hurt Biden, Caplan said. My prediction is he wont run again. Trump may fall to the same problem.

Brain processes like attention, memory, executive function, decision making, planning and judgment are critical core functions in high-risk activities or jobs like flying a plane, or leading a country, Nagamatsu, of Western U, said.

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But its an individual, case-by-case thing. The degree and rate of decline varies widely and isnt just determined by age, she said. Theres no magical age that says time to stop. Im sure that you know some individuals who are much younger that would not be fit to lead a country.

The market is responding to aging consumers with devices to help them stay healthy and independent longer. Some of Sinhas patients refuse to wear the clunky pendants that come with some personal emergency response systems, or PERS. I dont want to wear that cowbell, one told him. But bundle a PERS in a sleek smart watch, and there you have it. We have to remember that older people, like younger people theyre vain, Sinha said.

Why wear something that makes you feel old?

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Why 80 is the new 60: 'It's the triumph of aging' but not for everyone - National Post

By Peter LoewiThe Nome Census Area returned to the CDCs high community transmission level last week after a small infection surge was detected in Nome and five surrounding villages.As of press time on Tuesday, there are 19 active cases in the region: Twelve in Nome, three in Elim, two in Wales, one in Golovin and one in Unalakleet.While statewide hospital capacity remains available, the case rates have been among the highest in the nation. Also last week, Alaska reached the unfortunate distinction of being the state with the highest per-capita rates of COVID-19 overall since the start of the pandemic.Current hospitalizations in Alaska are the highest they have been since mid-February.The City of Nome continues to provide masks and at-home tests free of charge. They can be picked up at the City Hall, the Nome Recreation Center and the Richard Foster Building at the Kegoayah Kozga Public Library.The original batches of at-home tests distributed by the City list an expiration date of June, but in July, the Food and Drug Administration granted a three-month shelf-life extension to both the iHealth Antigen Rapid Tests and the AccessBio Antigen Home Tests. As the tests are under Emergency Use Authorization, the actual efficacy over time is still being studied. According to a FDA factsheet, Once the test manufacturer has more stability testing results, such as 12 or 18 months, the test manufacturer can contact the FDA to request that the FDA authorize a longer shelf-life. When a longer shelf-life is authorized, the expiration dates will be extended and the test manufacturer may send a notice to customers to provide the new authorized expiration dates, so the customers know how long they can use the tests they already have.Of the 22 authorized at-home over-the-counter diagnostics tests listed on the FDA website, nine have had their original expiration dates extended by several months.On Saturday, President Joe Biden again tested positive for COVID-19, in what is being called a COVID rebound case. In late May, the U.S. Centers for Disease Control and Prevention issued a health alert about people testing positive a second time shortly after receiving a course of Pfizers antiviral drug Paxlovid. Rebounds do not appear to lead to serious illness, and after mild symptoms the first time, the president is said to be asymptomatic.As cases rose across the country, the FDA had debated allowing younger adults to get a second booster, as the immunity granted by the shots wane. However, as even the single booster provides robust protection against hospitalization and death, the plan for summer boosters has been delayed until the fall, by which point an Omicron-specific booster is expected to be available.

The week in numbers:On Tuesday, July 26, Norton Sound Health Corporation identified 12 new cases of COVID-19 in the region. Seven cases were in Nome, two were in Elim. Brevig Mission, Shishmaref and Unalakleet each had one case.This meant that the number of active cases in the region reached 42. Twenty-four of the active cases were in Nome, seven were in Unalakleet, five in Elim, three in Brevig Mission, two in Wales and one in Shishmaref.On Wednesday, July 27, NSHC identified six new cases of COVID-19 in the region. Three of the new cases were in Nome. Brevig Mission, Shaktoolik and Shishmaref each had one.The number of active cases across the region dropped to 37. There were 24 in Nome, five in Unalakleet, three in Brevig Mission, and one in each of Shaktoolik, Shishmaref and Wales.On Thursday, July 28, NSHC identified eight new cases of COVID-19: Five in Unalakleet, two in Nome, and one in Brevig.On Friday, July 29, NSHC identified three new cases: One in each of Golovin, Nome and Wales.On Saturday, July 30, NSHC identified two new cases: One in each of Nome and Wales.On Sunday, July 31, NSHC identified four new cases all in Nome.The weekend releases brought the number of active cases in the region down to 16. There were nine active cases in Nome, four in Unalakleet, two in Wales, and one in Golovin.On Monday, August 1, NSHC identified seven new cases. Four of them were in Nome and three were in Elim. There are 19 active cases in the region: 12 in Nome, three in Elim, two in Wales, one in Golovin, and one in Unalakleet.Since the start of the pandemic the USA has had 91,485 officially reported cases of COVID-19 and 1,030,564 associated deaths.Alaska has had at least 271,101 cases of COVID-19, 3,826 hospitalizations and 1,275 deaths. There are currently 83 people hospitalized due to COVID-19.Nome, the Bering Strait and Norton Sound region has had at least 6,235 cases, 46 hospitalizations and six deaths.

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COVID infection numbers are slightly rising - The Nome Nugget

The Role

Do you seek a tree change or an opportunity to earn a big city salary and live the country life? Our ideal candidate will be suited to working on a relatively small Defence site located in Scottsdale, Tasmania. A small rural community - where the air is cleaner, the grass is greener, the food is fresher and nature abounds with serenity and adventure. We will cover all reasonable relocation costs.

We provide opportunities for a long standing career where you can be supported to grow your expertise through on-going formal and informal learning and development activities.

We are seeking an enthusiastic and resourceful food scientist to join our niche team of food scientists, in partnering with academia, Government and industry, to conduct world-class collaborative research and development on shelf-stable foods. You will find creative solutions for complex technical problems across a range of food science and technology fieldsinvestigating, interpreting and transforming knowledge and technology into Defence capabilities. You will have the opportunity to understand challenges, analyse problems and deliver food and feeding solutions with immediate and enduring positive impact to Defence; as well as opportunity for further training and career development.

In this your role as a Food Science Researcher you will:

At times, the role may require significant hands-on effort at the laboratory bench and in the food research pilot plant, including preparation, experiment execution and clean-up activities. At times, the role may involve significant desk-based effort to review the literature, analyse data and write reports, and to perform other computer-based tasks. The role also includes experimentation and data collection in military environments, for example during field training exercises.

About The Food & Nutrition (F&N) Team

Our team consists of a diverse team of Defence scientists who come together to provide impartial food and nutrition-related advice and innovative solutions to the Australian Defence Force (ADF). Our mission is to ensure that the nutritional status of ADF personnel is optimal for the achievement of their military tasks across a range of challenging training and operational environments. Our work involves a broad range of F&N science activities, including food processing, food safety systems, new product development, specification writing, food chemistry, microbiology, packaging, supply chain/logistics, sensory and consumer science, nutrition and dietetics.

Our Ideal Candidate

Our ideal candidate will be an optimistic, proactive and highly motivated person who is comfortable working within an agile environment with continually evolving requirements. You will have relevant technical knowledge and/or experience in one or more food science capabilities, which may include food formulation, processing (e.g. retorting) and packaging, food safety, shelf life extension (of shelf-stable foods), nutrient stabilisation and fortification, test and evaluation of food safety and quality, and sensory and consumer science.

You will be able to work productively both as an individual and as a team member. You will be confident in investigating and addressing issues impacting achievement of outcomes. You value strong trust-based relationships and stakeholder engagement and are willing to share and receive learnings and support of/to others. You will be a proven communicator at a technical and non-technical level. To be successful you will require academic qualifications in one or more relevant areas of food science and/or equivalent demonstrated research skills and work experience appropriate to the duties of this position.

Application Closing Date: Thursday 18 August, 2022

For further information please review the job information pack, reference DSTG/03985/22 on https://defencecareers.nga.net.au/?jati=AE17B89F-7958-AA00-216C-C8BB62DAD497

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Food Science Researcher job with Department of Defence | 304261 - Times Higher Education

WALTHAM, Mass., Aug. 08, 2022 (GLOBE NEWSWIRE) -- Viridian Therapeutics, Inc. VRDN, a biotechnology company advancing new treatments for patients suffering from serious diseases underserved by current therapies, today announced it will report its financial results from the second quarter ended June 30, 2022, before the financial markets open onMonday, August 15, 2022.

The Company's management team is scheduled to host a conference call at8:00 a.m. ETonMonday, August 15, 2022. To access the call, please dial 1-877-407-0789 in theU.S.or 1-201-689-8562 outside theU.S.and ask for the Viridian call. To access the live webcast, please visit the "Events" page in the Investors section of the Viridian Therapeutics, Inc. website. Following the live webcast, an archived version of the call will be available on the website.

Monday,August 15@8:00 a.m. ET

About Viridian Therapeutics

Viridian Therapeuticsis a biotechnology company advancing new treatments for patients suffering from serious diseases but underserved by today's therapies. Viridian's most advanced program, VRDN-001, is a differentiated monoclonal antibody targeting insulin-like growth factor-1 receptor (IGF-1R), a clinically and commercially validated target for the treatment of thyroid eye disease (TED). Viridian's second product candidate, VRDN-002, is a distinct anti-IGF-1R antibody that incorporates half-life extension technology and is designed to support administration as a convenient, low-volume, subcutaneous injection.TED is a debilitating autoimmune disease that causes inflammation and fibrosis within the orbit of the eye which can cause double vision, pain, and potential blindness. Patients with severe disease often require multiple remedial surgeries to the orbit, eye muscles and eyelids. Viridian is based inWaltham, Massachusetts.

Investor and Media Contact:John JordanViridian TherapeuticsVice President, Investor Relations& Corporate Communications617-272-4691IR@viridiantherapeutics.com

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Viridian Therapeutics to Report Second Quarter 2022 Financial Results and Host Conference Call on August - Benzinga

A non-nuclear mock B61-12 Joint Test Assembly (JTA) being prepared for test loading inside the B-2A Spirit stealth bombers bombs bay. (U.S. Air Force photo by Airman 1st Class Devan Halstead)

The U.S. Air Force recently released on the Defense Visual Information Distribution Service (DVIDS) website a series of interesting photos from Whiteman Air Force Base, Missouri. The photos, taken on June 13, 2022, show a high-fidelity, non-nuclear mock B61-12 Joint Test Assembly (JTA) being prepared for test loading inside the B-2A Spirit stealth bombers bombs bay. To our knowledge, these should be the first public photos of the weapon with the Spirit since testing aboard the aircraft has begun few years ago.

The Air Force did not provide many details and did not even mention the name of the bomb, simply stating the 72nd Test and Evaluation Squadron test loads a new nuclear-capable weapons delivery system for the B-2 Spirit bomber. The 72nd TES, a geographically separated unit of Eglin AFBs 53rd Wing based at Whiteman, is in charge of all testing and evaluation of new equipment, software and weapons systems for the B-2 Spirit stealth bomber.

It is not clear what the caption refers to with the term nuclear-capable weapons delivery system. The unofficial Nuclear Matters Handbook of the office of the Deputy Assistant Secretary of Defense for Nuclear Matters, gives us the following definition:

A nuclear weapon delivery system is the military platform and delivery vehicle by which a nuclear weapon is delivered to its intended target in the event of authorized use (by the President of the United States, who retains sole authority to employ nuclear weapons). Most nuclear weapons have been designed for a specific delivery system, making interoperability potentially challenging.

In addition to the mix of silo-based Minuteman III (MMIII) ICBMs, Trident II D5 Life Extension (LE) SLBMs carried on Ohio-class SSBNs, and B-2A and B-52H nuclear-capable heavy bombers, the U.S. nuclear force includes dual-capable aircraft (DCA), that can carry conventional or nuclear weapons.

Judging by this definition, the weapon delivery system in question should be the B-2A bomber, however the fact that the caption mentions the test loading aboard the aircraft might mean that this system is a new weapon rack inside the bombs bay designed to work with the new B61-12. Available public info states that the Spirit was designed to employ a Bomb Rack Assembly (BRA) for conventional munitions and a Rotary Launcher Assembly (RLA) for the delivery of conventional or nuclear weapons.

The BRA was later upgraded between 2003 and 2006 and became a Smart Bomb Rack Assembly capable of carrying as many as 80 independently targeted, JDAM GPS-guided weapons. So, since the new B61-12 in equipped with a guidance kit, it is possible that also the RLA is now being upgraded to use the new bomb. The new bomb variant will replace the B61-7 and B61-11 currently available for the B-2 fleet.

As we already reported, The B61 entered service 50 years ago and has undergone a Life-Extention Program (LEP) to consolidate and replace four legacy bomb variants, the B61 -3, -4, -7, and -11 mods, into the B61-12. The refurbished B61-12 will allow the retirement of the larger B83, becoming the only remaining gravity delivered nuke in the inventory. The bomb will carry a low-yield nuclear warhead with four yield options, reportedly 0.3 kilotons, 1.5 kilotons, 10 kilotons and 50 kilotons, instead of larger warheads like the models it is replacing (which can reach 400 kilotons depending on the variants).

The 12-foot, 825-pound bomb is designed to be delivered from the air in either ballistic or guided-gravity drop modes, thanks to a new Boeing-built tail assembly that includes an Inertial Navigation System (INS) precision-guidance package and two spin rocket motors that improve the bombs stability on its longitudinal axis during the descent. The LEP is said to be increasing the B61s accuracy so much (with a reported 30 m Circular Error Probability instead of the original 100 m) that it will have the same capability against hardened targets as the much more powerful weapons it is replacing.

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U.S. Air Force Releases Photos Of Mock B61-12 Nuclear Bomb Test Loaded On B-2A Bomber - The Aviationist

Global Wellness Supplements Market Continuous Trend, Recent Events, Competitive Scenarios And Regional Forecast To 2029

DBMR added a comprehensive research document of 350+ pages on Global Wellness Supplements Market Share, Size, Industry Trends and Forecast 2029 with detailed insights on growth factors and strategies. Wellness Supplements report has been structured after a thorough study of various key market segments like market size, share, growth, demand, latest trends, market threats and key drivers which drives the market. Strategically analyzed facts and figures of the market and keen business insights covered in this industry analysis report would be a key aspect in achieving enduring business growth. The report offers steadfast knowledge and information of revolutionizing market landscape, what already exists in the market, future trends or what the market expects, the competitive environment, and strategies to plan to outshine the competitors.

Market Analysis and Insights: Wellness Supplements Market

The Wellness Supplements market is expected to witness market growth at a rate of 6.95% in the forecast period of 2022 to 2029. Data Bridge Market Research report on wellness supplements market provides analysis and insights regarding the various factors expected to be prevalent throughout the forecast period while providing their impacts on the markets growth. The rise in the awareness towards healthy lifestyles among the people worldwide is escalating the growth of wellness supplements market.

Wellness supplements are known to be substances that are projected to add further nutritional value to the diet for boosted health. Wellness supplements are vital for upholding a healthy life. Supplements contain all the minerals in sufficient amount to meet the daily need for the healthy life. Food supplement frequently contain calcium, folic acid, vitamin D and vitamin b12.

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Life Extension, OPTAVIA LLC, Beachbody LLC, Natures Sunshine Products, Inc., Organo Gold., Thrive Life, LLC, Phytoscience Trvo, Oriflame Cosmetics AG, Melaleuca Inc, Shaklee Corporation, Arbonne International, LLC., Forever Living.com, L.L.C, Juice Plus+, Herbalife International of America, Inc, and Isagenix Worldwide LLC, Nikken Inc., Wellness Resources, Inc., The Daily Wellness Company, Otsuka Holdings Co. Ltd, Glanbia plc, Nestle, Nuskin, and USANA Health Sciences, Inc.

By Type:

By Application

Academic Institutes, Clinical and Diagnostic Laboratories, Pharmaceutical and Biotechnology Companies and Others

3) Geographically, this report is located on several key regions with sales, revenue, and market share as well as growth rate of Wellness Supplements covered in these regions, 2021-2029.

Countries covered by Global Wellness Supplements Market are Argentina, Australia, Austria, Belgium, Brazil, Canada, Chile, China, Colombia, Czech Republic, Denmark, Egypt, Germany, Finland, France, Hong Kong, India ., Indonesia, Ireland, Israel, Italy, Japan, Malaysia, Mexico, Netherlands, New Zealand, Nigeria, Norway, Peru, Philippines, Poland, Portugal, Romania, Russia, Saudi Arabia, Singapore, South Africa, South Korea, Spain, Sweden, Switzerland, Thailand, Turkey, United Arab Emirates, United Kingdom, United States, Venezuela, Vietnam.

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Global Wellness Supplements Market Will Record Significant Revenue Growth During The Forecast Period 2022-2029 Designer Women - Designer Women

This is an audio transcript of the FT Weekend podcast episode: How to live forever

Lilah RaptopoulosHello FT Weekend listeners, its Lilah. Im away on vacation this week so weve reached into the vault to bring you one of our favourite episodes. My team and I talk about this episode a lot. Its about living forever and the ethics of radical life extension. Its also about defying death on this outrageous family summer vacation, which feels relevant for the season. One quick note: this episode first published in November. So in the beginning, when I say last year, I mean March of 2020. Okay, enjoy the show.

Did I ever tell you about the time Ira Glass almost gave me coronavirus? It was the last day of going about our normal lives in March of 2020, and everything was starting to shut down and my office was closing, so I packed up my laptop and my keyboard and some of my notebooks into these kind of unwieldy tote bags and I slung them over my shoulder and headed home. But my last stop was this one final interview with the iconic radio host in the studios of This American Life. So Ira and I sat together in the small audio booth for an hour, and we talked about the art of storytelling, and then I left. The next day his assistant emailed me to say that I might have coronavirus because Ira might have coronavirus because he had shaken hands with someone who had coronavirus. And I remember thinking, this cannot be how I go. And that was my first brush with mortality during the pandemic and the first of many. For the next few months, mortality and I became friends. We, like, encountered each other very regularly, going to the grocery store, passing a neighbour in the hallway, taking a walk. We all encountered it, all the time. There are some people who come face to face with death early because theyve had loved ones get sick and pass. And it happens more often to us as we get older. But these past 18 months, its been different. We have a new relationship with death. Weve had to face it either as a reality or as a real possibility.

[MUSIC PLAYING]

Lilah RaptopoulosThis is FT Weekend, the podcast. Im Lilah Raptopoulous. This weekend, were thinking about mortality. Do we look death in the face or do we avoid it altogether? Were going to the extreme ends. One of the worlds top climbers defies death by scaling treacherous mountains with his kids. And FT science writer Anjana Ahuja takes us through the science of living for hundreds of years.

[CLIP PLAYING]

Leo HouldingWhat did you do today, Jackson?

Jackson HouldingWe climbed up the Pingora Peak.

Leo HouldingWhich ones that? You point to it.

Jackson HouldingThat one.

Lilah RaptopoulosThats Leo Houlding, an outdoor adventurer and a guest writer for FT weekend, chatting with his four-year-old son, Jackson.

[CLIP PLAYING]

Leo HouldingWas it hard?

Jackson HouldingUmm, not very, but a bit.

Leo HouldingWas it were you scared at all?

Jackson HouldingNo.

Lilah RaptopoulosLeo recently took his family on a vacation that would leave most of us fearing for our lives. Thats them climbing up Pingora Peak, a mountain described by the first Europeans who saw it as impossible. It was a 14-day trek deep in Wind River Country in the wilderness of Wyoming. He and his wife, Jessica, took their two kids scrambling up isolated technical terrain. Theyre four and eight. Heres Leo with his daughter, Freya, climbing Wolfs Head, a 12,000-foot summit that would be hard for most adults.

[CLIP PLAYING]

Leo HouldingWhats happening, Freya?

Freya HouldingAh, well, Ive just gone up that ridge and Im, whoo! That ridge.

Leo HouldingAwesome. [Freya making sounds while climbing] There goes Freya, heading up that east ridge of the Wolfs Head. Pretty epic. One of the more epic features youre ever likely to see anywhere in the world.

Lilah RaptopoulosOn this trip, there was no cell service. They slept in tents and they brought all their food. Some of the climbing was almost vertical roped climbing and full harnesses. Leo talks about all of this in his piece, which Ive linked to in the show notes, but it sounded so outrageous that I wanted to talk to him about it.

Leo HouldingI think discomfort is underrated and our lives are so comfortable these days. Were all kind of obsessed with making everything as comfortable as possible, whereas actually a good dose of discomfort just makes you appreciate a little bit of comfort so much more.

Lilah RaptopoulosIt should be said that Leo is sort of a climbing celebrity. Hes considered one of the best in the world. You may have seen him. Hes been in documentaries like The Wildest Dream, an Imax film that documents a climb up Everest. And hes been on TV shows like Top Gear. Hes been to Antarctica twice to climb some of the most secluded mountains in the world. So it isnt just that he wants to torture his kids. He believes in this stuff for himself, too. So off they went into the wilderness, the whole family, and two unexpected hired hands.

Leo HouldingThe problem is to do that as a family of four, you need quite a lot of stuff. Aside from the climbing gear, you need all the camping gear, sleeping gear, cooking gear and, most of all, you need food for 14 days. Total was about 100 kilos of equipment. And thats where the llamas came in. (Laughter)

Lilah Raptopoulos(Laughter) Right. Okay. So in your story, youre talking about your van getting stuck and your kids being kind of like unsure about it and youre waiting for someone to help you out. And then this groan comes from the trailer behind you.

Leo HouldingNot many people know that llama trekking is a thing in the western states. There are a couple of outfitters who rent you llamas unguided. Theyre extremely easy animals to look after, unlike horses, which, you know, you kind of have to know stuff to handle horses.

Lilah RaptopoulosSo Leo, his wife, two kids, two llamas, 14 days worth of food and gear. They avoid a moose almost immediately as they get into the backwoods. And at this point, theyre going upwards, but not climbing just yet. On the walk to their camping spot, they meet a hiker who shows them an edible mushroom the size of a football. So they take that with them. And then when they set up camp, Leos wife, Jessica, casts her fishing rod out and immediately pulls back a perfect fish. Like in the movies.

At that stage, what were you thinking? Were you thinking, okay, were good. This is going to be an easy trip?

Leo HouldingI knew it wasnt going to be an easy trip because going into the backcountry is never easy. In fact, its very hard, but its simple. You know, you dont have all the complications of modern life. Its much more about shelter and food and looking after each other. I mean, we went into the Wind Rivers with a couple of objectives in mind, some big cliffs. But for most people that go there, they go there simply to experience the wilderness. Thats something that I would recommend to absolutely everyone.

Lilah RaptopoulosBut Leo and his family arent everyone. Jessica is also an experienced mountain climber, so on that third day, they take their kids out to climb some serious, bare-faced rocks.

Leo HouldingWe did this peak called Pingora, the east ledges of Pingora, which is Jacksons first big climb where he didnt get carried. And I mean, it is a big climb. Its 1,000 feet of climbing, but the face is 2,000 feet high. You kind of come in from the side. So its, its incredibly spectacular.

Lilah RaptopoulosThe following day, Leo takes Freya on a climb thats too hard for Jackson, so they go with one of his climbing buddies.

Leo HouldingIts definitely one of the best kind of easier climbs in North America, if not the world. Its this knife-edge ridge, you know, no more than a metre wide with pretty much 300m drops on both sides, outrageously exposed. Its quite complicated terrain. You have to squirm through chimneys and you have to rappel a bit and you have to go sideways. Going sideways in climbing is actually more difficult to protect than going straight up, and watching my little girl, she got scared, you know. Of course she got scared. But she faced her fear, she controlled her breathing and she absolutely loved it. She was just grinning from ear to ear the whole day.

Lilah RaptopoulosYeah, I have to say, as you tell the story, my heart is beating fast. I imagine that, like a lot of it. And tell me if Im wrong, that a lot of it is just deciding kind of not to be scared.

Leo HouldingThats a big part of it for sure. You know, kids, whatever you introduce them to is normal for them. So Jackson, whos only five, he was only four this summer when when we did some big climbs out in America. Hes just picking his nose, eating his sweets, looking at the birds, wittering away like any other four-year-old would in any other situation. Freya is extremely confident. Shes grown up in the mountains so shes way better than most adults in that terrain. In fact, we actually overtook a couple of adult teams and they were polite about it. But it must have been a little disheartening seeing a cute little eight-year-old skipping past you (laughter) on your big adventure.

Lilah RaptopoulosAll along, Leo had planned to go on an even more serious climb right at the end of their two weeks. Just him and his climbing partner. Theyre gone for just 24 hours. And when they get back nursing cramps and muscle spasms, they find out that the rest of his family had to fend off a bear. Did I not mention? The story also includes a bear.

Leo HouldingShe tried the old banging pans together to scare it off. She did have a kind of bear spray and a hiking pole, but it was snuffling around for, you know, a few hours through the night. And then she realised there was still some food in the pots, in one of these stuff sacks. So she gingerly pushed it out from underneath the tent and ironically, the noise of that scared it off.

Lilah RaptopoulosIf you have kids at this point, you might be asking yourself, is this a little too dangerous? Why is this guy putting his kids at risk? Going into the backcountry with two little kids is one thing, but treacherous climbs, foraged food, bears?

Leo HouldingI mean, theres no question that going into the mountains, going into the backcountry is dangerous. But sometimes people think of me as a professional climber, as an adventurer, as a risk-taker. But the truth is, its very much about risk management. Its about reducing the risks as much as possible. Any idiot can roll the dice a couple of times and get away with it. But when you do it professionally and you do high-risk stuff all the time, you have to do it with a very high degree of safety. But, you know, risk is an inherent part of all life, not just lives of adventure and life in the mountains. You kind of have to accept risk in life to be able to go out and make the most of it.

Lilah RaptopoulosBut Leo says thats the point.

Leo HouldingYou know, we had a couple of pretty serious storms and there was a lot of tears and screaming, as there is in many situations with kids. But actually, sometimes its the, its the low points, its the negative experiences which are the most memorable and most formative. Now, when you get to the top of the mountain, its all smiles and high fives and sunshine. Thats great. But when youre being pelted by hail, thats kind of leaving bruises. And, you know, my wife and I were literally stooped over the kids protecting them from this vicious hail storm. And thats when they learn, as we do, that, you know, you can survive, you can endure, you can push on through, dont give up. And you just have to kind of stay on top of the situation. And then when the sun does come out, you can dry off and live to fight another day.

[MUSIC PLAYING]

Lilah RaptopoulosAnd from looking death in the eye to trying to delay it forever. If you had the chance to undergo a therapy that would let you live for 200 years in your prime body, would you do it? Im talking 200 years in the body of a 35-year-old. Not just a longer life, but a longer life thats actually good. There are scientists working hard on making that possible right now, thanks in part to funding from billionaires like Jeff Bezos. But if Bezoss space launch was criticised for wasting money, how do we feel about his quest for eternal life? Should we consider it urgent medical research? Or is this just rich mans folly? Do we really want a hacker biology to live to 200? Think about it.

[MUSIC PLAYING]

Anjana AhujaYou know, if a woman could reset her biology and have the biology of a, you know, perpetually of a 30-year-old, then what happens to the concept of generations? Are we all going to be living you know, when we talk about multigenerational households, are we talking about instead of the three at the moment, maybe four, five, six?

Lilah RaptopoulosThats Anjana Ahuja, a contributing science writer for the FT. Anjana recently wrote the cover story for Life & Arts on this radical idea. It was called, Can we defeat death? And it asks just that. Can we actually live for hundreds of years or forever? And yeah, thats a real headline from a real newspaper, not a sci-fi novel, written by a real, distinguished journalist who actually has a PhD in space physics. So heres where we are. We arent close yet to making humans age in reverse. But scientists have been able to de-age cells in living organisms. There are mice that go blind from ageing. And we can manipulate their genes so that they can see again. Were close enough to a Benjamin Button situation that philosophers are now publishing books about the morality of extending the human lifespan.

So I cant stop thinking about your piece. (Laughter) Im just like, yeah, and Im wondering, like, where this started for you. Where did you start reporting it?

Anjana AhujaBack in September, I wrote a column about Altos Labs. I found out that it was being set up, it was being funded by Jeff Bezos. And to me, it seemed like a really serious outfit in terms of the money that was going into it, the people they were recruiting. And Ive always thought this, that actually somebody, sooner or later, is going to look at ageing as a technological problem because there is so much research into kind of interfering, trying to hack the ageing process.

Lilah RaptopoulosAltos is a Silicon Valley start-up and Anjana says it expands on the work of Shinya Yamanaka, a Nobel Prize-winning physiologist who heads Altoss scientific board. In 2006, Yamanaka made a discovery that some people consider even more important than the discovery of the DNAs double helix.

News clipThe Nobel Assembly at Karolinska Institute has today decided to award the Nobel Prize in physiology or medicine 2012 to Shinya Yamanaka.

Lilah RaptopoulosHis research showed that if you take an adult mouse cell and bathed in a mixture of four proteins, you can reset that cells age back to its embryonic state. In 2007, he proved that it could be done with human skin cells. Let me say that again. If you dunk individual cells in this particular cocktail of proteins, you can make those cells not just stop ageing. You can make them younger. And we, of course, are made entirely of cells.

Im curious what, like, the practical implications would be of these findings? Like, would it be just that individual parts of your body, those cells, could kind of Benjamin Button themselves backwards and yet you still would look old? Like, is there is there a way to sort of make the entire body young? Thats a very dumb question. But is there a way to make the whole body younger?

Anjana AhujaNo, its not a dumb question at all. I think thats really what these billionaires are hoping for, isnt it, to kind of freeze themselves in some kind of eternally youthful state? I think thats a very good question. The key is how you translate from individual cells up to whole organisms.

Lilah RaptopoulosThe name for what happens when you bathe cells in the Yamanaka Factor proteins is cellular reprogramming. Scientists try to reprogramme the cells of an entire body on mice, but when they did, the mice grew these horrible malignant tumours. Anjana put it like this. She said once you bring the cells back to their embryonic state, they lose their life plan. They dont know what to do next, so they grow into cancers. But there are companies right now working to see if you can apply these factors incrementally to de-age cells as far as you can without them developing cancer and then to do it again.

Anjana AhujaI suspect people will be quicker to apply it to individual organs first, individual tissues. You know, when you think about the number of people whose organs just wear out, they need transplants. So that might be an option.

Lilah RaptopoulosThis research, it isnt the only path to reverse ageing. A California scientist has been giving a small group of middle-aged men this cocktail of drugs that includes diabetes medication. Its made their thymus glands, which is a key part of the immune system, younger by two-and-a-half years. David Sinclair, a Harvard geneticist and one of the biggest names in anti-ageing. Hes doing a lot to experiment on his own body, including only eating one or two meals a day to put his body into survival mode. But Yamanakas discovery and where its going, thats whats really changing the game for longevity research. And to tell you the truth, thinking about it really pushed me on my assumptions about scientific progress, especially progress driven by Jeff Bezos.

These stories can look a little like the stories of men with too much money in Silicon Valley (laughter) just trying to like, kind of like, still be young and cool, right? Like, kind of suspend reality and like, isnt there something, even if its hard, comforting about the fact that we understand that, like, theres a limit to our lives and we understand the arc of it and, and we all die.

Anjana AhujaYeah, I mean, why dont these billionaires put their money to solving climate change and starvation and, you know, giving us clean drinking water and that kind of thing? You know, whats really interesting to me, I think, is when you think about what healthcare is.

Lilah RaptopoulosMmhmm.

Anjana AhujaIts about postponing death.

Lilah RaptopoulosYeah.

Anjana AhujaYou know, if you say to someone, you know, if you could not have cancer, not have heart disease, not have Alzheimers, not have dementia, if you could find a therapy that did that, would you take it? And I think there would be a lot of people that would say yes.

Lilah RaptopoulosMmhmm.

Anjana AhujaAnd what the scientists are saying, well, actually, you know, ageing is the common factor in lots of these diseases.

Lilah RaptopoulosMmhmm.

Anjana AhujaSo instead of, you know, kind of waiting till Alzheimers or heart disease or diabetes hits, why dont we make an upstream intervention and stop the root cause, or one root cause, which is ageing?

Lilah RaptopoulosAt the moment, though, most people seem to be sceptical of radical life extension. Anjana quotes the survey in her piece that only four per cent of Americans recently said theyd want to live past 120. Statistically, thats pretty close to no Americans wanting to live past 120. And Anjanas right! Part of that scepticism is that we cant imagine our world without Alzheimers, cancer and heart disease because the image we have is of old age as we know it now, one that is inextricably linked to disease and frailty and loneliness. But even if we could get rid of the negative consequences of ageing, if we can have lives that arent just longer but good till the end, should we? Have we really thought this through? What about the climate crisis and overpopulation and burning through our limited resources? What about marriage? Can you stay married to one person for 150 years? How many careers should we have over 200 years? What about dictators who dont ever die? Supreme Court justices? What about the House of Lords?

Anjana AhujaWhat do you do in the judicial system? You know, what does a life sentence mean, if youre living for 150, 200 years?

Lilah RaptopoulosYeah.

Anjana AhujaAnd just this idea that kind of a lot of institutions in society are set up with finite life spans in mind.

Lilah RaptopoulosAs we ended this conversation, I held two opposing feelings at once. One is, if this discovery happened today, it would be a nightmare on a macro scale, and we are not ready for it. And the other is, if I could give someone I love whos suffering from degenerative disease a pill to stop their pain or to reverse the damage, I would in a heartbeat, no question. And to not feel that way is kind of to be against progress.

Anjana AhujaI think there are some really important issues that may well become more important in the decades ahead. I dont know how close any of this is to fruition, this work about, you know, radical life extending. Could I live to 200? I dont know. And Im not sure that I would necessarily be able to make that decision today.

Lilah RaptopoulosYeah.

Anjana AhujaI think I would want to see what state the science was in, what state the research was in, what state I was in, and what kind of life I felt I could have, how I felt psychologically about it, what my family feel about it. You know, do they want me hanging around for a hundred years (laughter)?

Lilah RaptopoulosWould the people around you also be hanging around for an extra 100 years?

Anjana AhujaExactly. You know, we are going to get horribly bored with each other. So who knows? I mean, these are really big issues, but I hope that the piece is open to debate and we should talk about these things. Theyre always good because you never know how fast science is going to progress. Yeah. And sometimes, as weve seen with, you know, gene editing and CRISPR, sometimes these things hit before weve had a chance to think about them.

Lilah RaptopoulosMmhmm.

Anjana AhujaAnd I think its always really useful for us to just take a step back and reflect on how we live, how science might change things, and on what we feel comfortable with and, and, you know, the future of our species and our society.

Lilah RaptopoulosAnjana, youve given me so much to think about and probably our listeners too. Thank you so much for being on the show.

Anjana AhujaOh, its been my pleasure, Lilah. Thank you for having me!

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Lilah RaptopoulosAnd a final thought. We may be doing some of this life extension work already. We do live in a world of optimisation. We have apps to help us meditate. Our phones count our steps. We have strange little tools we attach to the back of our necks to help our posture. My watch tells me to stand up and breathe. My friends have a bed that heats up and cools down according to their optimal body temperature. There are start-ups that make vitamins specifically for your personal constitution. This isnt just scientists in a lab testing proteins on mice. This is kind of already happening.

Tiffany DarkeSo actually, what these tools, all the good tools for longevity that are coming into the market do is they help increase your health span as opposed to your life span.

Lilah RaptopoulosThats Tiffany Darke. Shes a regular contributor to the FTs luxury magazine, How to Spend It. She just wrote a piece on what the really rich are doing now to optimise their health. And shes pretty into it.

Tiffany DarkeIm a bit of a luxury junkie. Ive always, like, appreciated fashion. And I think that the science and the thought leadership around the luxury wellness industry has sort of increased exponentially in recent years.

Lilah RaptopoulosLets be clear. Living long is a luxury. The difference between being wealthy and poor can translate to living 10 or 20 years longer or shorter. And living long well, thats an even bigger luxury. In the UK, 20 per cent of mens lives are spent in poor health, a number thats increasing. And for women, thats even higher. Its 23 per cent. But for those that can afford it, there are a lot of new options. Were going to take you through a few of them here. The first is called RoseBar. Its a destination longevity programme and its marketing offers you a pretty bold promise.

Tiffany DarkeIt says a year from now, you can be younger. So they are promising reversal of ageing.

Lilah RaptopoulosThe RoseBar programme is a year-long programme. First they run longevity diagnostics and your bloodwork to see if youre on any negative health trajectories. And if you are, they put you on antidotes, which could be plasma treatments or even stem cell manipulation. From there, they give you fitness and diet advice and monthly check-ins. And the first programme launches this month at a resort in Ibiza. Its got a hyperbaric chamber, cryotherapy and IV facilities and literal shamans. Its like buying a souped-up life coach.

Tiffany DarkeYes, yes, life coach but with lots of kind of doctors and clinicians and all the sort of fun toys that surround the longevity industry as well.

Lilah RaptopoulosThe cost is, base, 15,000.

Tiffany DarkePlus the actual residential costs, plus getting there, plus the cost of the nutraceuticals, plus all the treatments.

Lilah RaptopoulosIf thats a bit too steep for you, theres a start-up called Thriva. Its an app that sends you a blood sample kit. The cost starts around $30 and can go as high as almost $200 per test, depending on your add-ons.

Tiffany DarkeIm warning you, its totally addictive. So you download this app on to your phone and then they send you a blood test and you do your blood test every three months. And its really easy at home, pinprick in the end of your finger.

Lilah RaptopoulosThey test what your doctor does at a normal check-up: your cholesterol, kidney and liver function, testosterone, vitamin levels. But they test it way more frequently and they put the results in an app, gamified. Next are the supplements. Lima sells supplements with nine scientifically backed ingredients: D3, keratin, ashwagandha, turmeric, stuff like that, but branded to look cool. You may have heard them referred to as the supermodel supplements: four pills a day, $300 a month, and you even get a luxe copper vessel to store them in.

Tiffany DarkeTheres a lot of hocus-pocus in the supplement market and, you know, a lot of good marketing, but actually there are supplements out there that do use good, patented adaptive medicines and at the dosages that your body needs to really thrive.

Lilah RaptopoulosWhich begs the question, are these just high-tech tools reminding us to do the obvious? Eat vegetables, avoid processed foods, take your vitamins, drink water, get sleep, exercise. Its all advice thats as old as time, but its a lot easier to follow when you can afford to get real-time data. And it doesnt hurt to have a shaman reminding you on a beach in Ibiza.

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Lilah RaptopoulosThats it for this week. Youve been listening to FT Weekend, the podcast from the Financial Times. Please keep in touch, say hi, tell me what you like, what issues you want to hear us explore. You can email us at ftweekendpodcast@ft.com. Were on Twitter @FTWeekendPod and Im on Instagram and Twitter @LilahRap. Ill put some photos of Leos family adventure on my feeds and, really, reach out. We love to put listeners on the show. In our show notes, as always, are links to everything mentioned. Theres also a special discount there on an FT Weekend subscription or even an FT.com trial. Weve got the best discounts collected for you in that link, which you can also get to at ft.com/weekendpodcast. Please leave us a review and share the show on your Twitter or Instagram story or with a few friends. This really is the best way you can help support the show.

Im Lilah Raptopoulos. Katya Kumkova and George Drake Jr are our senior producers. Lulu Smyth and Josh Gabert Doyan are our assistant producers, and Breen Turner is our sound engineer, with original music by Metaphor Music. Cheryl Brumley and Manuela Saragosa are our executive producers, and we have editorial direction from ReneKaplan. Well find each other again next week.

See the article here:
How to live forever - Financial Times