Archive for the ‘Regenerative Medicine’ Category

Prolotherapy has as its current primary applications in the treatment of:

With a precise injection of a mild irritant solution directly on the site of the torn or stretched ligament or tendon, Prolotherapy creates a mild, controlled injury that stimulates the bodys natural healing mechanisms to lay down new tissue on the weakened area. The mild inflammatory response that is created by the injection encourages growth of new ligament or tendon fibers, resulting in a tightening of the weakened structure. Additional treatments repeat this process, allowing a gradual buildup of tissue to restore the original strength to the area. Injection of varicose veins and other similar abnormalities creates a mild inflammatory response causing them to contract so that they become smaller or even vanish.

Each patient must be evaluated thoroughly with patient history, physical exam, X-ray exam, and full laboratory work up before treatment will be administered. With this information, your physician can evaluate your potential success with this therapy. Success depends on factors which include the history of damage to the patient, the patients overall health and ability to heal, and any underlying nutritional deficiencies that would impede the healing process.

This form of therapy can be used to treat dislocation of the joints, knee pain, shoulder pain, Temporal Mandibular Joint dysfunction, Carpal Tunnel Syndrome, and disc problems at any level of the spine. The therapy affects only the area treated and does not cause any problem in any other area. Spider veins, abnormal or bulging veins and other similar conditions can be treated on the legs, feet, hands, arms, breast, face, and most other areas.

The treatments should be administered every one, two, or three weeks, as determined by your treating physician. Vein treatments are usually scheduled four or more weeks apart. The American Osteopathic Association of Prolotherapy Regenerative Medicine, Inc. is dedicated toward improving the practice of, and disseminating knowledge about Prolotherapy. (Previously known as Sclerotherapy)

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American Osteopathic Association of Prolotherapy ...

Regenerative medicine is a multidisciplinary field involving biology, medicine and engineering. It combines the physical nature of a product with living cells.

"Tissue Regeneration," "Tissue Engineering" and "Regenerative Medicine" are related terms and are sometimes used interchangeably.

Where does regenerative medicine fit into modern medical practice? Current traditional approaches to treat medical diseases include:

These methods are all considered essential, but have their limitations. For example, drugs have unwanted side effects, prosthetics are not biologically active and do not integrate or remodel into the body, surgery is invasive, and organ transplantation is limited by donor availability and toxic immunosuppressive cocktails.

Regenerative medicine is an emerging approach in modern medicine as it delivers living tissue, stimulating the body's own natural healing process by activating the body's inherent ability to repair and regenerate. Innovative therapies are now available that aim to heal or reconstruct diseased tissue and support the regeneration of diseased or injured cells and organs.

Doctors use regenerative medicine to speed up healing and to help injuries that will not heal or repair on their own. Regenerative medicine may help heal broken bones, severe burns, chronic wounds, heart damage, nerve damage, and many other diseases.

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Organogenesis.com - Science - Regenerative Medicine

The Institute for Regenerative Medicine is based in the Smilow Center for Translational Research and extends across UPenns campus.

The links between medicine, engineering and veterinary science differentiate Penns Institute for Regenerative Medicine from other stem cell Institutes across the country.

The IRM promotes discoveries in stem cell biology and regeneration to generate new therapies that may alleviate suffering and disease.

When our interdisciplinary research and programs bring together individuals with broad interests and diverse backgrounds, our collaborations lead to greater advances.

Stem cell research is critical to developing new skin tissues and, ultimately, changing the way we care for devastating wounds.

At Penn, we're discovering real possibilities of future treatments for cardiac disease because we have the research and clinical expertise to make it happen.

Wednesday - March 23, 2016

This spring, the BioEYES program celebrates a major milestone: It will serve its 100,000th student. That means in the 14 years since BioEYES began, 100,000 elementary, middle, and high school students from Philadelphia and four

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Wednesday - February 10, 2016

A study from researchers at The Childrens Hospital of Philadelphia may add new lines to the textbook description of how cancer cells divide uncontrollably and develop into tumors. Their study, published in Nature Communications, identifies

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Wednesday - January 27, 2016

Scientists say gene editing holds the key to curing a host of intractable diseases, including cystic fibrosis, HIV, cancer, and cataracts, to name a few. Policymakers fear that, if this key fell into the wrong

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IRM at UPenn - Institute For Regenerative Medicine - Phila

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Regenerative Medicine

Regenerative Medicine is the process of engineering living, functional cell and tissue-based therapies and administering these to patients to repair or replace tissue or organ function lost due to age, disease, damage, or congenital defects. Target diseases include cancers, diabetes, heart disease, ALS and target disorders include spinal/movement, hearing loss, vision loss, and neurological (i.e., stroke).

Nearly all currently available and development stage regenerative medicine products and therapies utilize biopreservation processes and products in the acquisition of source material, isolation and manipulation of specific cells, and storage and shipment of a final product dose to a patient location. System optimization is critical and biopreservation economics greatly impact product commercialization potential through shelf life impact on distribution, and clinical dose efficacy following preservation.

This market is comprised of nearly 700 commercial companies and numerous other hospital-based transplant centers developing and delivering cellular therapies such as stem cells isolated from bone marrow, peripheral and umbilical cord blood as well as engineered tissue-based products. MedMarket Diligence, LLC, estimates that the current worldwide market for regenerative medicine products and services is growing at 20 percent annually. We expect pre-formulated biopreservation media products such as our HypoThermosol and CryoStor to continue to displace home-brew cocktails, creating demand for clinical grade preservation reagents that will grow at greater than the overall end market rate.

We have shipped our proprietary biopreservation media products to over 200 regenerative medicine customers. We estimate that our products are now incorporated into 30 to 40 regenerative medicine cell- or tissue-based products in pre-clinical and clinical trial stages of development. While this market is still in an early stage, we have secured a valuable position as a supplier of critical reagents to numerous regenerative medicine companies and university based centers.

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Regenerative Medicine - Biolife Solutions, Inc.

Cells are the building blocks of tissue, and tissues are the basic unit of function in the body. Generally, groups of cells make and secrete their own support structures, called extra-cellular matrix. This matrix, or scaffold, does more than just support the cells; it also acts as a relay station for various signaling molecules. Thus, cells receive messages from many sources that become available from the local environment. Each signal can start a chain of responses that determine what happens to the cell. By understanding how individual cells respond to signals, interact with their environment, and organize into tissues and organisms, researchers have been able to manipulate these processes to mend damaged tissues or even create new ones.

The process often begins with building a scaffold from a wide set of possible sources, from proteins to plastics. Once scaffolds are created, cells with or without a cocktail of growth factors can be introduced. If the environment is right, a tissue develops. In some cases, the cells, scaffolds, and growth factors are all mixed together at once, allowing the tissue to self-assemble.

Another method to create new tissue uses an existing scaffold. The cells of a donor organ are stripped and the remaining collagen scaffold is used to grow new tissue. This process has been used to bioengineer heart, liver, lung, and kidney tissue. This approach holds great promise for using scaffolding from human tissue discarded during surgery and combining it with a patients own cells to make customized organs that would not be rejected by the immune system.

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Tissue Engineering and Regenerative Medicine | National ...

At Mayo Clinic, an integrated team, including stem cell biologists, bioengineers, doctors and scientists, work together and study regenerative medicine. The goal of the team is to treat diseases using novel therapies, such as stem cell therapy and bioengineering. Doctors in transplant medicine and transplant surgery have pioneered the study of regenerative medicine during the past five decades, and doctors continue to study new innovations in transplant medicine and surgery.

In stem cell therapy, or regenerative medicine, researchers study how stem cells may be used to replace, repair, reprogram or renew your diseased cells. Stem cells are able to grow and develop into many different types of cells in your body. Stem cell therapy may use adult cells that have been genetically reprogrammed in the laboratory (induced pluripotent stem cells), your own adult stem cells that have been reprogrammed or cells developed from an embryo (embryonic stem cells).

Researchers also study and test how reprogrammed stem cells may be turned into specialized cells that can repair or regenerate cells in your heart, blood, nerves and other parts of your body. These stem cells have the potential to treat many conditions. Stem cells also may be studied to understand how other conditions occur, to develop and test new medications, and for other research.

Researchers across Mayo Clinic, with coordination through the Center for Regenerative Medicine, are discovering, translating and applying stem cell therapy as a potential treatment for cardiovascular diseases, diabetes, degenerative joint conditions, brain and nervous system (neurological) conditions, such as Parkinson's disease, and many other conditions. For example, researchers are studying the possibility of using stem cell therapy to repair or regenerate injured heart tissue to treat many types of cardiovascular diseases, from adult acquired disorders to congenital diseases. Read about regenerative medicine research for hypoplastic left heart syndrome.

Cardiovascular diseases, neurological conditions and diabetes have been extensively studied in stem cell therapy research. They've been studied because the stem cells affected in these conditions have been the same cell types that have been generated in the laboratory from various types of stem cells. Thus, translating stem cell therapy to a potential treatment for people with these conditions may be a realistic goal for the future of transplant medicine and surgery.

Researchers conduct ongoing studies in stem cell therapy. However, research and development of stem cell therapy is unpredictable and depends on many factors, including regulatory guidelines, funding sources and recent successes in stem cell therapy. Mayo Clinic researchers aim to expand research and development of stem cell therapy in the future, while keeping the safety of patients as their primary concern.

Mayo Clinic offers stem cell transplant (bone marrow transplant) for people who've had leukemia, lymphoma or other conditions that have been treated with chemotherapy.

Mayo Clinic currently offers a specialty consult service for regenerative medicine within the Transplant Center, the first consult service established in the United States to provide guidance for patients and families regarding stem cell-based protocols. This consult service provides medical evaluations for people with many conditions who have questions about the potential use of stem cell therapy. The staff provides guidance to determine whether stem cell clinical trials are appropriate for these individuals. Regenerative medicine staff may be consulted if a doctor or patient has asked about the potential use of stem cell therapies for many conditions, including degenerative or congenital diseases of the heart, liver, pancreas or lungs.

People sometimes have misconceptions about the use and applications of stem cell therapies. This consult service provides people with educational guidance and appropriate referrals to research studies and clinical trials in stem cell therapies for the heart, liver, pancreas and other organs. Also, the consult service supports ongoing regenerative medicine research activities within Mayo Clinic, from basic science to clinical protocols.

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Regenerative Medicine - Transplant Center - Mayo Clinic

Colorado Clinic offers multiple regenerative medicine stem cell treatments. These treatments are provided as an outpatient by a Double Board Certified Doctor. Each treatment maintains minimal risk, with the possibility of providing repair and healing of injured tendons, ligaments, cartilage and muscle.

Click on the Treatments on the Left Tabs for more information.

Stem Cell Treatments at Colorado Clinic

Traditional therapies for osteoarthritis, ligament injury and tendonitis maintain certain commonalities. They help provide excellent pain relief, however, they do not alter the condition or help with the healing process. They act as an excellent band aid, but they do not REPAIR the problem!

The newest treatments for helping repair the damage involve Regenerative Medicine. The therapies are cutting edge and include stem cells, platelets, growth factors and cytokines.

Here is an example of what regenerative medicine offers. When a football player sustains a rotator cuff tendon injury, it may heal by itself in six to 10 weeks. Healing of damaged tendons or ligaments may occur naturally. However, it does not reach 100% strength like it was before.

With regenerative medicine, this situation may be very different. Healing of the rotator cuff injury may occur much faster, and it may reach 100% normal strength. This can help prevent future injury and get patients back on the field faster.

Regenerative treatments may permit patients to avoid or delay the need for surgery when it comes to all sorts of injury. The most common of these is degenerative arthritis. Joint replacement surgery is not without risk, therefore, stem cell treatments may help repair some of the cartilage damage while providing substantial pain relief.

With minimal risk, outpatient stem cell treatments offer a substantial upside. Make your appointment at Colorado Clinic today!

Amniotic Stem Cell Injections

Life comes from birth. Its one of the most commonly accepted rules in our society. But can the birth process offer even more? As research and science evolved over time, studies have shown that amniotic stem cells can have a revolutionary effect on the human recovery process.

First, lets look at what amniotic stem cells are. Stem cells are the basic components (cells) of our human body. One of their most amazing characteristic is that they can become almost any type of cell, from muscle to bone or skin cell.

Amniotic stem cells are obtained from the amniotic fluid, which is produced during a caesarean birth. During pregnancy, the amniotic fluid protects the fetus and it feeds it with the necessary supplements needed to sustain life and development. A while back, this fluid was normally discarded, but once researchers got to understand its amazing therapeutic benefits, now its collected and stored because of its high concentration of pluripotent stem cells.

Amniotic derived stem cell fluid comes from consenting donors and is processed at an FDA regulated lab. It is checked for all sorts of diseases prior to being accepted for use in others.

Although stem cells have been used for decades, regenerative therapy is fairly new, and sometimes pushes the boundaries of human imagination and perception. Following the use of amniotic stem cell injections, more evidence reveals exciting results in muscle repair and pain relief which has made amniotic stem cells possibly the holy grail in treatment.

Amniotic stem cell injections offer the ability to heal damaged tissue naturally. The tissue regeneration and repair properties of the amniotic stem cell fluid are an effective anti-inflamatory that relieves pain and contains natural growth factors that assist in healthy tissue growth. Moreover, the hyaluronic acid that is also in amniotic fluid is an important component of the joint fluid that helps cartilage growth. Amniotic fluid is also a great source of stem cells, found in a much higher concentration than the adult bone marrow. And just like when one uses their own stem cells, the use of amniotic fluid doesnt cause rejection or allergic reaction when injected into a patient.

Amniotic stem cell injections have been getting more attention since they have been openly used by prominent athletes with impressive results and even a few saved careers! The ability to safely and effectively treat painful and debilitating injuries and conditions of the knees, elbows, and shoulders without lengthy rehabilitation or recovery time isnt just appealing to professional athletes, but to anyone who wants relief from pain and to return to their favorite activities.

Initial small studies are showing that amniotic stem cell injections work well for the following indications: 1) Tendonitis 2) Ligament Injury 3) Arthritis 4) Sports Medicine Injuries 5) Cartilage Defects

Dr. Sisson at Colorado Clinic is an expert in regenerative medicine treatments. Call the practice today for an appointment!

Bone Marrow Derived Stem Cell Injections for Musculoskeletal Problems

What are Bone Marrow Derived Stem Cell Injections?

There are many types of stem cell injections that are currently in research mode. One type of stem cell injection currently used for many types of degenerative conditions is the bone marrow derived stem cell injection. This type of stem cell treatment is excellent for degenerative disc disease, joint arthritis, ligament injuries, spinal arthritis, and tendonitis. Studies have shown that therapy using regenerative treatment, such as bone marrow stem cell injections, work well for degenerative conditions.

Bone Marrow Derived Stem Cell Collection and Injection

Bone marrow derived stem cell injections are an outpatient procedure where a patients bone marrow is harvested. It is then processed and injected into the area of concern in the same setting. In bone marrow derived stem cell injections, collection is done in an outpatient procedure which takes about 30 minutes. The bone marrow derived stem cells are collected using a catheter and local anesthetic.

The bone marrow derived stem cells are removed from the body in the blood, circulated through a machine with the filtered blood, and returned to the patients body in the same procedure. The stem cells are filtered out of the blood using the aspheresis machine, which retains only the stem cells.

What is the Future of Bone Marrow Derived Stem Cell Injections?

The future of bone marrow derived stem cell injections is a bright one. There are two types of bone marrow stem cells that can be derived from the tissue composing the middle of the bones, mesenchymal, and hematopoietic stem cells. It is the hematopoietic stem cells that differentiate back into blood cells among other things, and the mesenchymal cells that differentiate into skeletal and vertebral tissues.

Bone marrow derived stem cell injections are showing excellent results for tendonitis, ligament injuries and degenerative arthritis. This can help produce great results for athletes and individuals who desire to avoid or delay the need for joint replacement surgery.

Dr. Sisson at Colorado Clinic is at the forefront of regenerative medicine treatments with stem cells. You will be in good hands!

PRP Therapy at Colorado Clinic

The Facts about PRP Injections

Platelet-rich (PRP) therapy is a form of therapy that is used for damage that occurs within the tendons, ligaments, and joints. This type of therapy works by stimulating repair within the areas that are damaged, while also providing pain relief for the area where the therapy is used. PRP therapy has been around for quite some time, but has only recently become a more common method of treatment for musculoskeletal conditions.

Due to the ease of application, and the very few side-effects present with PRP therapy, it is commonly replacing other treatments that are more invasive, such as surgical procedures.

What exactly is PRP Therapy?

PRP therapy is often called platelet-rich plasma therapy, and this type of therapy is provided in the form of an injection. Initially, about 30-60cc of blood is drawn from the patients arm. It is placed into a centrifuge machine and separates into several layers. The middle layer contains concentrated platelets and growth factors and is used in the treatment for injection into the problem area.

Your blood is composed of several different parts, and when the blood is put into a medical machine that spins it at a fast rate, the platelets are separated from the blood, collected, and then put into a vial in a concentrated amount. The collected platelets are then injected into the area that is damaged, which provides the pain relief and repairing effects for the area. This allows the patient to get the platelets and growth factors needed for healing, while also using the bodys own resources, which eliminates the possibility of side-effects occurring due to the body rejecting the injection that is made.

The platelets that are removed from the blood are the same ones within the blood that stick to one another when we are injured and the blood clots. While the blood as a whole is known to have great healing powers, the platelets are one of the most effective healing components of the blood. When injected into the different damaged areas of the body, they are able to call in stem cells, and also allow for regeneration of the soft tissue.

How does PRP Therapy Work?

When the PRP injection is made, the solution goes directly into the area that is damaged, and also into the areas surrounding the damage. The therapy is known to provide pain relief within a week for patients in up to 80% of cases, due to the ability ofthe injections to stimulate healing in the area at a much faster rate than what your body is able to provide. Platelet rich plasma also contains significant amounts of growth factors, and even severe damage can be healed over time with the use of this form of therapy.

Where can PRP be Used?

PRP therapy can be used in all of the joints within the body, and even areas of soft tissue that are damaged such as the shoulder, elbow, achilles, etc. This may include tendonitis, ligament injury or degenerative arthritis.

Platelet-rich plasma therapy at Colorado Clinic is offered by the top pain management and regenerative medicine doctor in Northern Colorado, Dr. Sisson. He has extensive experience with regenerative medicine including PRP therapy, make your appointment today!

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Regenerative Medicine - Colorado Clinic

MetroMD Institute of Regenerative Medicine provides consumers and Healthcare Providers opportunities to benefit from uniquely effective services and products belonging to a new branch of Twenty-First Century medicine called Regenerative Medicine.

The evidenced-based, new technologies of Regenerative Medicine address health & Cosmetic problems currently unresolved by conventional medical-surgical approaches.

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Stem cell therapy is the utilization of stem cells to prevent or treat a condition or a disease. A weekend warrior is a person who tries to fit in all the fitness activities of the week into a session or two usually on the weekend. In most cases, they do more that their bodies can[]

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I had spent two years in physical therapy while being bounced from Specialist to Specialist, all who repeatedly told me they did not know what was wrong or how to fix my lower back pain. The problem was that my right SI joint would slip out of place, causing severe pain and considerable restriction. It seemed the only solution would be to fuse the joint, but every Doctor refused because I was only 25 years old. I was close to giving up when I was finally referred to Dr. Scott Horn. He was the first Doctor to tell me that he could help. He told me about a procedure known as Prolotherapy. He described the process to me and told me he felt it was my best bet. I was hesitant because it involved needles and I've never been very good with it. Nonetheless, I was close to desperation and Dr. Horn was the first Doctor to tell me he could help. So I agreed.

To my utter relief, Prolotherapy worked! After the third session I started to notice a difference. My SI joint slipped less and was easier to manipulate back in when it did. I did five sessions total and by the fifth one, I was already able to walk around the block with no pain! The change was amazing, I was vacuuming, sweeping, even dancing a little, all with no slipping of my SI joint. This was a major difference from the point where I'd bend over to pick up a pencil and it would slip out.

Prolotherapy was a blessing! It gave me back my life, letting me live like a 25 year old should! I'm active again and it's all thanks to the patience of Dr. Horn and his staff! Dr. Horn and his nurses were phenomenal! They were all professional, courteous and just a pleasure to interact with. They were always quick to greet me and even keep me distracted during the session. I've never been good with needles, but Dr. Horn and his group worked wonders! If ever I need any pain management in the future, I would return to Dr. Horn in a heartbeat. I truly cannot say enough good things about him or his staff and the work they do!

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Biologic Healing Regenerative Medicine

Dr.DorisTayloris involved in both laboratory and clinical studies using cell therapy to treat disease. Almost5 million Americans are living with heart failure and more than half a million new cases are diagnosed annually. Almost 50,000 people die each year while awaiting a heart transplant and, for a decade or more, only about 2,200 heart transplants have been performed in the entire United States. The need is dwarfed by the availability of donor organs.

This is one of the reasons there is such hope placed in the promising field of regenerative medicine. The groundbreaking work of Dr. Taylor and her team has demonstrated the ability in the lab to strip organs, including the heart, of their cellular make-up leaving a decellularized "scaffold." The heartcan then be re-seeded with cells that, when supplied with blood and oxygen, regenerate the scaffold into a functioning heart. Dr. Taylor calls this using nature's platform to create a bioartificial heart.

The hope is that this research is an early step toward being able to grow a fully functional human heart in the laboratory. Dr. Taylor has demonstrated that the process works for other organs as well, such as kidney, pancreas, lung, and liver where she has already tested the same approachopening a door in the field of organ transplantation.

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About Regenerative Medicine Research at the Texas Heart ...

Journal of Regenerative Medicine Journal of Regenerative Medicine (JRGM) is a peer-reviewed scholarly journal and aims to publish the most complete and reliable source of information on the discoveries and current developments in the mode of original articles, review articles, case reports, short communications, etc. in all areas of stem cells and regenerative medicine and making them available online freelywithout any restrictions or any other subscriptions to researchers worldwide. Journal of Regenerative Medicine focuses on the topics include regenerative medicine therapies, stem cell applications, tissue engineering, gene and cell therapies, translational medicine and tissue regeneration. The Journal is using Editorial Manager System for quality in review process. Editorial Manager is an online manuscript submission, review and tracking system. Review processing is performed by the editorial board members ofJournal Regenerative Medicine or outside experts; at least two independent reviewers approval followed by editor approval is required for acceptance of any citable manuscript. Authors may submit manuscripts and track their progress through the system, hopefully to publication. Reviewers can download manuscripts and submit their opinions to the editor. Editors can manage the whole submission/review/revise/publish process. Interested authors can submit manuscript through Online Submission System or Editorial Manager or send as an e-mail attachment to the Editorial Office ateditor.jrgm@scitechnol.com oreditor.jrgm@scitechnol.org Journal of Regenerative Medicine is organizing & supporting3rd International Conference on Tissue Science & Regenerative Medicine during September 24-26, 2014 Valencia, Spain with the theme ofBreakthrough Strategies for Tissue Engineering, Repair & Regeneration.

*Unofficial 2014 Impact Factor was established by dividing the number of articles published in 2012 and 2013 with the number of times they are cited in 2014 based on Google search and the Scholar Citation Index database. If X is the total number of articles published in 2012 and 2013, and Y is the number of times these articles were cited in indexed journals during 2014 than, impact factor = Y/X.

Heterogeneity of Stem Cells in Human Amniotic Fluid

Amniotic fluid contains a mixture of cells with capacity to differentiate into all germ layers. These cells are present in large numbers in midtrimester samples obtained for cytogenetic diagnosis, and have been identified by stem cell surface markers and transcription factors. We studied cultured samples from patients who had both direct cultures and matched cultures obtained 2 weeks later from the cytogenetics laboratory as well as patients with cytogenetics material only. Samples were cryogenically frozen, thawed, expanded in culture with excellent viability. There was considerable individual variation unrelated to gestational age or telomere length. Phenotype for embryonic markers was assessed by flow cytometry and by quantitative polymerase chain reaction. The most consistently present stem cell markers in substantial amounts were CD90, SSEA-4, & TRA-1-60. Cells with CD90, SSEA-4 & TRA-1-60 double and triple labeled also could be identified and subcultured, confirming the heterogeneity of the amniotic fluid stem cell population.

Patent Knowledge and Stem Cell Scientists

The knowledge economy is progressing at a rapid pace and increasingly relying on intangible assets as a form of recoupling its investments. Intangible assets include intellectual capital and intellectual property, with an emphasis on patents here. Due to the unawareness about intellectual property rights, researchers, very often, are flying blind unaware of opportunities and threats posed by patents to their research projects. Although, the business acumen of many (private and public) scientists has markedly increased in recent years, large numbers are still left outside the patent loop of opportunities and knowledge of obstacles to their research. Knowledge about patents carries important implications for all researchers and those responsible for science and technology policy making.

Platelet-Rich Plasma Therapies:In the Right Pathway to Find their Regulatory Niche

The Spanish Agency of Medicines and Medical Devices (AEMPS) has recently regulated the use of platelet-rich plasma (PRP), that is,patients own plasma enriched in platelets and therefore in proteins and growth factors, as a human use drug. It is the first time that one regulatory agency worldwide categorizes these types of therapeutic therapies. According to AEMPS, PRP approaches cannot be considered as an advanced-therapy medicinal product. PRPs are classified as non-industrial biological medicines, being subjected to a strict regulation in terms of production, validation, efficacy and safety.

Understanding Somatic (Adult)Stem Cells: Potential vs. Reality

In the adult mammal, reserve stem cells, both active and quiescent, serve as primary precursors for differentiated cells. They often provide replacement cells as needed during normal cell homeostasis or serve as residual stem cell sources during periods of stress, trauma or disease. Adult stem cells have a defined level of maturity, accompanied by stability of differentiation, are less likely to invoke an immune response and are often readily derived from reservoirs in bone marrow, blood, adipose tissue and a variety of placental related tissues. While certain adult stem cells are well established as normal cell precursors and used in the treatment of diseases, an expanding array of specific adult stem cells from muscle, heart, nervous tissue, etc. are being discovered and posited as cell progenitors for regenerative therapy. Current preclinical and clinical tests are designed to test the identity, safety, efficacy, and methodology of harvested stem cells or derived cell lines for therapy of specific disorders. Contemporary therapeutic venues, bio-cell, drug and treatment centers have proposed the use of specific adult stem cells for human therapy in regenerative medicine.

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Regenerative Medicine Journals | Stem Cell Articles List

AGENDA PROCEEDINGS

Congratulations to trainees who won prizes!From left: Marissa Scavuzzo (RU), Gautham Yepuri (HMRI), Samantha Paulsen (RU), Danielle Wu (RU), and John Leach (BCM). Not pictured: Alexander Tatara (RU)

Stem Cell Category: Trainee Speakership and Award: John Leach, Baylor College of Medicine Hippo signaling deletion in heart failure reverses functional declineLeach J, Heallen T, Zhang M, Rahmani M, Martin J

1st Place Poster Award: Marissa Scavuzzo,Baylor College of Medicine Isl1 Directs Cell Fate Decisions in the Pancreas by Specifying Progenitor Cells Towards Different Endocrine LineagesScavuzzo MA, Yang D, Sharp R, Wamble K, Chmielowiec J, Mumcuyan N, Borowiak M

2nd Place Poster Award: Gautham Yepuri, Houston Methodist Research Institute Proton Pump Inhibitors Impair Vascular Function By Accelerating Endothelial SenescenceYepuri G, Sukhovershin R, Nazari-shafti TZ, Ghebremariam YT, Cooke JP

Tissue Engineering Category: Trainee Speakership and Award: Samantha Paulsen, Rice University 3D printing vascularized tissues: Closing the loop between computational and experimental models Paulsen SJ, Miller JS

1st Place Poster Award: Alexander Tatara, Rice University Using the Body to Regrow the Body: In vivo Bioreactors for Craniofacial Tissue EngineeringTatara AM, Shah SR, Lam J, Demian N, Ho T, Shum J, Wong ME, Mikos AG

2nd Place Poster Award: Danielle Wu, Rice University Building Salivary Cell Mini-Modules: A First Step Toward Reconstruction of the Human Salivary GlandWu D, Pradhan-Bhatt S, Cannon K, Chapela P, Hubka K, Harrington D, Ozdemir T, Zakheim D, Jia X, Witt RL, Farach-Carson MC

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2015 Cluster for Regenerative Medicine Symposium

An International Leader in Regenerative Medicine

The Wake Forest Institute for Regenerative Medicine (WFIRM) is a leader in translating scientific discovery into clinical therapies.

Physicians and scientists at WFIRM were the first in the world to engineer laboratory-grown organs that were successfully implanted into humans. Today, this interdisciplinary team is working to engineer more than 30 different replacement tissues and organs and to develop healing cell therapies-all with the goal to cure, rather than merely treat, disease.

Regenerative medicine has been called the "next evolution of medical treatments," by the U.S. Department of Health and Human Services. With its potential to heal, this new field of science is expected to revolutionize health care.

"We have many challenges to meet, but are optimistic about the ability of the field to have a significant impact on human health. We believe regenerative medicine promises to be one of the most pervasive influences on public health in the modern era."- Anthony Atala, MD, Director

Why is public education on regenerative medicine important?Watch the videos below from leaders in the field of regenerative medicine to get this answer and learn more.The Regenerative Medicine Network is a newly formed collaboration between the Regenerative Medicine Foundation and MDTV Inc. The network will be a digital information and education hub available to the public through participating web portals such as the Wake Forest Institute for Regenerative Medicine.

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Wake Forest Institute for Regenerative Medicine - Official Site

When injured or invaded by disease, our bodies have the innate response to heal and defend. What if it was possible to harness the power of the body to heal and then accelerate it in a clinically relevant way? What if we could help the body heal better?

The promising field of Regenerative Medicine is working to restore structure and function of damaged tissues and organs. It is also working to create solutions for organs that become permanently damaged. The goal of this medicine is to find a way to cure previously untreatable injuries and diseases.

1

Some patients must manually empty their bladder but the complications dont end there. The inability to urinate at will, or even to regulate the build up of urine, could cause back up into the kidneys, creating life-threatening damage.

But wait, a revolutionary event has occurred! A series of child and teenage patients have received urinary bladders grown from their own cells! This is the first ever laboratory-grown organ transplant placed into a human, all made possible by Regenerative Medicine.

Regenerative Medicine is working to improve the quality of life for patients all over the world. Scientists work with this powerful technology to create new body parts from a patients own cells and tissues. Success of these efforts will eliminate the concept of tissue rejection.

Learn more about the study of artificial organs and how scientists are working to replace damaged or diseased tissue with synthetic devices (fully artificial organs) or synthetic and cellular components (biohybrid organs).

Also find out how medical devices provide the ability to sustain patients during their long wait for a donor organ, and occasionally eliminate the need for a transplant altogether.

2

Heart disease affects many Americans and the only current solution requires a heart transplant. Even if a patient is able to survive long enough to receive a heart, there is no promise that the body will not reject the foreign organ.

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RegenerativeMedicine.net - What is regenerative medicine?

regenerative medicine,cartilage: bronchus repair using bioartificial tissue transplantationHospital Clinic of Barcelona/APthe application of treatments developed to replace tissues damaged by injury or disease. These treatments may involve the use of biochemical techniques to induce tissue regeneration directly at the site of damage or the use of transplantation techniques employing differentiated cells or stem cells, either alone or as part of a bioartificial tissue. Bioartificial tissues are made by seeding cells onto natural or biomimetic scaffolds (see tissue engineering). Natural scaffolds are the total extracellular matrixes (ECMs) of decellularized tissues or organs. In contrast, biomimetic scaffolds may be composed of natural materials, such as collagen or proteoglycans (proteins with long chains of carbohydrate), or built from artificial materials, such as metals, ceramics, or polyester polymers. Cells used for transplants and bioartificial tissues are almost always autogeneic (self) to avoid rejection by the patients immune system. The use of allogeneic (nonself) cells carries a high risk of immune rejection and therefore requires tissue matching between donor and recipient and involves the administration of immunosuppressive drugs.

A variety of autogeneic and allogeneic cell and bioartificial tissue transplantations have been performed. Examples of autogeneic transplants using differentiated cells include blood transfusion with frozen stores of the patients own blood and repair of the articular cartilage of the knee with the patients own articular chondrocytes (cartilage cells) that have been expanded in vitro (amplified in number using cell culture techniques in a laboratory). An example of a tissue that has been generated for autogeneic transplant is the human mandible (lower jaw). Functional bioartificial mandibles are made by seeding autogeneic bone marrow cells onto a titanium mesh scaffold loaded with bovine bone matrix, a type of extracellular matrix that has proved valuable in regenerative medicine for its ability to promote cell adhesion and proliferation in transplantable bone tissues. Functional bioartificial bladders also have been successfully implanted into patients. Bioartificial bladders are made by seeding a biodegradable polyester scaffold with autogeneic urinary epithelial cells and smooth muscle cells.

Another example of a tissue used successfully in an autogeneic transplant is a bioartificial bronchus, which was generated to replace damaged tissue in a patient affected by tuberculosis. The bioartificial bronchus was constructed from an ECM scaffold of a section of bronchial tissue taken from a donor cadaver. Differentiated epithelial cells isolated from the patient and chondrocytes derived from mesenchymal stem cells collected from the patients bone marrow were seeded onto the scaffold.

There are few clinical examples of allogeneic cell and bioartificial tissue transplants. The two most common allogeneic transplants are blood-group-matched blood transfusion and bone marrow transplant. Allogeneic bone marrow transplants are often performed following high-dose chemotherapy, which is used to destroy all the cells in the hematopoietic system in order to ensure that all cancer-causing cells are killed. (The hematopoietic system is contained within the bone marrow and is responsible for generating all the cells of the blood and immune system.) This type of bone marrow transplant is associated with a high risk of graft-versus-host disease, in which the donor marrow cells attack the recipients tissues. Another type of allogeneic transplant involves the islets of Langerhans, which contain the insulin-producing cells of the body. This type of tissue can be transplanted from cadavers to patients with diabetes mellitus, but recipients require immunosuppression therapy to survive.

Cell transplant experiments with paralyzed mice, pigs, and nonhuman primates demonstrated that Schwann cells (the myelin-producing cells that insulate nerve axons) injected into acutely injured spinal cord tissue could restore about 70 percent of the tissues functional capacity, thereby partially reversing paralysis.

embryonic stem cell: scientists conducting research on embryonic stem cellsMauricio LimaAFP/Getty ImagesStudies on experimental animals are aimed at understanding ways in which autogeneic or allogeneic adult stem cells can be used to regenerate damaged cardiovascular, neural, and musculoskeletal tissues in humans. Among adult stem cells that have shown promise in this area are satellite cells, which occur in skeletal muscle fibres in animals and humans. When injected into mice affected by dystrophy, a condition characterized by the progressive degeneration of muscle tissue, satellite cells stimulate the regeneration of normal muscle fibres. Ulcerative colitis in mice was treated successfully with intestinal organoids (organlike tissues) derived from adult stem cells of the large intestine. When introduced into the colon, the organoids attached to damaged tissue and generated a normal-appearing intestinal lining.

In many cases, however, adult stem cells such as satellite cells have not been easily harvested from their native tissues, and they have been difficult to culture in the laboratory. In contrast, embryonic stem cells (ESCs) can be harvested once and cultured indefinitely. Moreover, ESCs are pluripotent, meaning that they can be directed to differentiate into any cell type, which makes them an ideal cell source for regenerative medicine.

Studies of animal ESC derivatives have demonstrated that these cells are capable of regenerating tissues of the central nervous system, heart, skeletal muscle, and pancreas. Derivatives of human ESCs used in animal models have produced similar results. For example, cardiac stem cells from heart-failure patients were engineered to express a protein (Pim-1) that promotes cell survival and proliferation. When these cells were injected into mice that had experienced myocardial infarction (heart attack), the cells were found to enhance the repair of injured heart muscle tissue. Likewise, heart muscle cells (cardiomyocytes) derived from human ESCs improved the function of injured heart muscle tissue in guinea pigs.

Derivatives of human ESCs are likely to produce similar results in humans, although these cells have not been used clinically and could be subject to immune rejection by recipients. The question of immune rejection was bypassed by the discovery in 2007 that adult somatic cells (e.g., skin and liver cells) can be converted to ESCs. This is accomplished by transfecting (infecting) the adult cells with viral vectors carrying genes that encode transcription factor proteins capable of reprogramming the adult cells into pluripotent stem cells. Examples of these factors include Oct-4 (octamer 4), Sox-2 (sex-determining region Y box 2), Klf-4 (Kruppel-like factor 4), and Nanog. Reprogrammed adult cells, known as induced pluripotent stem (iPS) cells, are potential autogeneic sources for cell transplantation and bioartificial tissue construction. Such cells have since been created from the skin cells of patients suffering from amyotrophic lateral sclerosis (ALS) and Alzheimer disease and have been used as human models for the exploration of disease mechanisms and the screening of potential new drugs. In one such model, neurons derived from human iPS cells were shown to promote recovery of stroke-damaged brain tissue in mice and rats, and, in another, cardiomyocytes derived from human iPS cells successfully integrated into damaged heart tissue following their injection into rat hearts. These successes indicated that iPS cells could serve as a cell source for tissue regeneration or bioartificial tissue construction.

Scaffolds and soluble factors, such as proteins and small molecules, have been used to induce tissue repair by undamaged cells at the site of injury. These agents protect resident fibroblasts and adult stem cells and stimulate the migration of these cells into damaged areas, where they proliferate to form new tissue. The ECMs of pig small intestine submucosa, pig and human dermis, and different types of biomimetic scaffolds are used clinically for the repair of hernias, fistulas (abnormal ducts or passageways between organs), and burns.

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regenerative medicine | Britannica.com

Regenerative medicine is a branch of translational research[1] in tissue engineering and molecular biology which deals with the "process of replacing, engineering or regenerating human cells, tissues or organs to restore or establish normal function".[2] This field holds the promise of engineering damaged tissues and organs via stimulating the body's own repair mechanisms to functionally heal previously irreparable tissues or organs.[3]

Regenerative medicine also includes the possibility of growing tissues and organs in the laboratory and safely implanting them when the body cannot heal itself. If a regenerated organ's cells would be derived from the patient's own tissue or cells, this would potentially solve the problem of the shortage of organs available for donation, and the problem of organ transplant rejection.[4][5][6]

Attributed to William Haseltine (founder of Human Genome Sciences),[7] the term "regenerative medicine" was first found in a 1992 article on hospital administration by Leland Kaiser. Kaisers paper closes with a series of short paragraphs on future technologies that will impact hospitals. One paragraph had Regenerative Medicine as a bold print title and stated, A new branch of medicine will develop that attempts to change the course of chronic disease and in many instances will regenerate tired and failing organ systems.[8][9]

Regenerative medicine refers to a group of biomedical approaches to clinical therapies that may involve the use of stem cells.[10] Examples include the injection of stem cells or progenitor cells obtained through Directed differentiation (cell therapies); the induction of regeneration by biologically active molecules administered alone or as a secretion by infused cells (immunomodulation therapy); and transplantation of in vitro grown organs and tissues (tissue engineering).[11][12]

From 1995 to 1998 Michael D. West, PhD, organized and managed the research between Geron Corporation and its academic collaborators James Thomson at the University of Wisconsin-Madison and John Gearhart of Johns Hopkins University that led to the first isolation of human embryonic stem and human embryonic germ cells.[13]

Dr. Stephen Badylak, a Research Professor in the Department of Surgery and director of Tissue Engineering at the McGowan Institute for Regenerative Medicine at the University of Pittsburgh, developed a process for scraping cells from the lining of a pig's bladder, decellularizing (removing cells to leave a clean extracellular structure) the tissue and then drying it to become a sheet or a powder. This extracellular matrix powder was used to regrow the finger of Lee Spievak, who had severed half an inch of his finger after getting it caught in a propeller of a model plane.[14][15][16][dubious discuss] As of 2011, this new technology is being employed by the military on U.S. war veterans in Texas, as well as for some civilian patients. Nicknamed "pixie-dust," the powdered extracellular matrix is being used to successfully regenerate tissue lost and damaged due to traumatic injuries.[17]

In June 2008, at the Hospital Clnic de Barcelona, Professor Paolo Macchiarini and his team, of the University of Barcelona, performed the first tissue engineered trachea (wind pipe) transplantation. Adult stem cells were extracted from the patient's bone marrow, grown into a large population, and matured into cartilage cells, or chondrocytes, using an adaptive method originally devised for treating osteoarthritis. The team then seeded the newly grown chondrocytes, as well as epithileal cells, into a decellularised (free of donor cells) tracheal segment that was donated from a 51 year old transplant donor who had died of cerebral hemorrhage. After four days of seeding, the graft was used to replace the patient's left main bronchus. After one month, a biopsy elicited local bleeding, indicating that the blood vessels had already grown back successfully.[18][19]

In 2009 the SENS Foundation was launched, with its stated aim as "the application of regenerative medicine defined to include the repair of living cells and extracellular material in situ to the diseases and disabilities of ageing." [20]

In 2012, Professor Paolo Macchiarini and his team improved upon the 2008 implant by transplanting a laboratory-made trachea seeded with the patient's own cells.[21]

On Sep 12, 2014, surgeons at the Institute of Biomedical Research and Innovation Hospital in Kobe, Japan, transplanted a 1.3 by 3.0 millimeter sheet of retinal pigment epithelium cells, which were differentiated from iPS cells through Directed differentiation, into an eye of an elderly woman, who suffers from age-related macular degeneration.[22]

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Regenerative medicine - Wikipedia, the free encyclopedia

Stem Cells, Regenerative Medicine, and Tissue Engineering

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Treatments classed as regenerative medicine help our natural healing processes work more rapidly and more effectively. These technologies can enable regeneration in missing or damaged tissue that would not ordinarily regrow, producing at least partial regeneration, and in some promising animal studies complete regeneration.

Strategies presently either under development, in clinical trials, or available via medical tourism include stem cell transplants, manipulation of a patient's own stem cells, and the use of implanted scaffold materials that emit biochemical signals to spur stem cells into action. In the field of tissue engineering, researchers have generated sections of tissue outside the body for transplant, using the patient's own cells to minimize the possibility of transplant rejection. Regenerative therapies have been demonstrated in the laboratory to at least partially heal broken bones, bad burns, blindness, deafness, heart damage, worn joints, nerve damage, the lost brain cells of Parkinson's disease, and a range of other conditions. Less complex organs such as the bladder and the trachea have been constructed from a patient's cells and scaffolds and successfully transplanted.

Work continues to bring these advances to patients. Many forms of treatment are offered outside the US and have been for a decade or more in some cases, while within the US just a few of the simple forms of stem cell transplant have managed to pass the gauntlet of the FDA in the past few years.

What Are Stem Cells?

Some of the most impressive demonstrations of regenerative medicine since the turn of the century have used varying forms of stem cells - embryonic, adult, and most recently induced pluripotent stem cells - to trigger healing in the patient. Most of the earlier successful clinical applications were aimed at the alleviation of life-threatening heart conditions. However, varying degrees of effectiveness have also been demonstrated for the repair of damage in other organs, such as joints, the liver, kidneys, nerves, and so forth.

Stem cells are unprogrammed cells in the human body that can continue dividing forever and can change into other types of cells. Because stem cells can become bone, muscle, cartilage and other specialized types of cells, they have the potential to treat many diseases, including Parkinson's, Alzheimer's, diabetes and cancer. They are found in embryos at very early stages of development (embyonic stem cells) and in some adult organs, such as bone marrow and brain (adult stem cells). You can find more information on stem cells at the following sites:

Embryonic and adult stem cells appear to have different effects, limitations and abilities. The current scientific consensus is that adult stem cells are limited in their utility, and that both embryonic and adult stem cell research will be required to develop cures for severe and degenerative diseases. Researchers are also making rapid progress in reprogramming stem cells and creating embryonic-like stem cells from ordinary cells.

Progress in Stem Cell Research

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Stem Cells, Regenerative Medicine, and Tissue Engineering

Though great progress has been made in medicine, current evidence-based and palliative treatments are increasingly unable to keep pace with patients' needs, especially given our aging population. There are few effective ways to treat the root causes of many diseases, injuries and congenital conditions. In many cases, clinicians can only manage patients' symptoms using medications or devices.

Regenerative medicine is a game-changing area of medicine with the potential to fully heal damaged tissues and organs, offering solutions and hope for people who have conditions that today are beyond repair.

Regenerative medicine itself isn't new the first bone marrow and solid-organ transplants were done decades ago. But advances in developmental and cell biology, immunology, and other fields have unlocked new opportunities to refine existing regenerative therapies and develop novel ones.

The Center for Regenerative Medicine takes three interrelated approaches:

Rejuvenation. Rejuvenation means boosting the body's natural ability to heal itself. Though after a cut your skin heals within a few days, other organs don't repair themselves as readily.

But cells in the body once thought to be no longer able to divide (terminally differentiated) including the highly specialized cells constituting the heart, lungs and nerves have been shown to be able to remodel and possess some ability to self-heal. Teams within the center are studying how to enhance self-healing processes.

Replacement. Replacement involves using healthy cells, tissues or organs from a living or deceased donor to replace damaged ones. Organ transplants, such as heart and liver transplants, are good examples.

The center aims to expand opportunities for transplants by finding ways to overcome the ongoing donor shortage, the need for immunosuppression and challenges with organ rejection.

Regenerative medicine holds the promise of definitive, affordable health care solutions that heal the body from within.

Stem cells have the ability to develop through a process called differentiation into many different types of cells, such as skin cells, brain cells, lung cells and so on. Stem cells are a key component of regenerative medicine, as they open the door to new clinical applications.

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About Regenerative Medicine - Mayo Clinic

Regenerative Medicine in the News...

Designing a Synthetic Gel that Changes Shape and Moves via Its Own Internal Energy

By developing a new computational model, McGowan Institute for Regenerative Medicine affiliated faculty member Anna Balazs, PhD, and Pitts Olga Kuksenok, PhD, have designed a synthetic polymer gel that can utilize internally generated chemical energy to undergo shape-shifting and self-sustained propulsion.

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Clifford Brubaker to End 25-Year Tenure as Dean of Health and Rehabilitation Sciences

Clifford E. Brubaker, PhD, who has served as professor and dean of the University of Pittsburgh School of Health and Rehabilitation Sciences for nearly 25 years, will step down from the deanship on July 1. Dr. Brubaker, a Distinguished Service Professor of Health and Rehabilitation Sciences, also holds appointments in the McGowan Institute for Regenerative Medicine, the Department of Neurological Surgery, and the Clinical and Translational Science Institute.

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Dr. Krzysztof Matyjaszewski Wins Dreyfus Prize

Krzysztof Matyjaszewski, PhD, the J.C. Warner University Professor of Natural Sciences at Carnegie Mellon University, has won the 2015 Dreyfus Prize in the Chemical Sciences, an international prize given every 2 years to recognize accomplishments in different areas of chemistry. Dr. Matyjaszewski is also a McGowan Institute for Regenerative Medicine affiliated faculty member.

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Regenerative Medicine at the McGowan Institute

Meet the Researcher: David Lott, M.D.
David Lott, M.D., Assistant Professor of Otolaryngology, presents Harnessing the Power of Regenerative Medicine for Head and Neck Reconstruction. This informal presentation was given...

By: Mayo Clinic

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Meet the Researcher: David Lott, M.D. - Video

Download The California Institute for Regenerative Medicine PDF
Download PDF here: http://bit.ly/1ImXWc2.

By: Scotty Chapin

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Download The California Institute for Regenerative Medicine PDF - Video

Download Cord Blood Stem Cells and Regenerative Medicine PDF
Download PDF Here: http://bit.ly/1GSodzZ.

By: Monet Siler

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Download Cord Blood Stem Cells and Regenerative Medicine PDF - Video

PRP from Queenstown Regenerative Medicine helps Ice Blacks Captain
This Interview with Ice Blacks Captain Bert Haines on his experience with PRP. Do you suffer from chronic pain or injury to ligaments, tendons and joints? Queenstown Regenerative Medicine...

By: Queenstown Regenerative Medicine

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PRP from Queenstown Regenerative Medicine helps Ice Blacks Captain - Video

Dr. Reuben Gobezie on regenerative medicine
Dr. Reuben Gobezie of Regen Orthopedics describes regenerative medicine in orthopedics. This non-surgical therapy has been shown to repair injured tissues with new, functioning tissues ...

By: Regen Orthopedics

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Dr. Reuben Gobezie on regenerative medicine - Video