Human Treg Responses Allow Sustained Recombinant Adeno-Associated VirusMediated Transgene Expression Recombinant adeno-associated virus (rAAV) vectors have shown promise for the treatment of several diseases; however, immune-mediated elimination of transduced cells has been suggested to limit and account for a loss of efficacy. To determine whether rAAV vector expression can persist long term, researchers administered rAAV vectors expressing normal, M-type ?-1 antitrypsin to AAT-deficient subjects at various doses by multiple i.m. injections. [J Clin Invest] Abstract | Press Release

SUMO-1 Gene Transfer Improves Cardiac Function in a Large-Animal Model of Heart Failure Toward clinical translation, scientists evaluated the effects of small ubiquitin-related modifier 1 (SUMO-1) gene transfer in a swine model of ischemic heart failure. After gene delivery, there was a significant increase in the maximum rate of pressure rise that was most pronounced in the group that received both SUMO-1 and SERCA2a. [Sci Transl Med] Abstract | Press Release

Aldehyde Dehydrogenase Expression Drives Human Regulatory T Cell Resistance to Posttransplantation Cyclophosphamide Scientists studied early T cell reconstitution in patients undergoing allogeneic blood or marrow transplantation with posttransplantation cyclophosphamide and the effects of mafosfamide, a cyclophosphamide analog, on CD4+ T cells in allogeneic mixed lymphocyte reactions in vitro. [Sci Transl Med] Abstract | Press Release

Hypoxic Mesenchymal Stem Cells Engraft and Ameliorate Limb Ischemia in Allogeneic Recipients Investigators evaluated the therapeutic potential of mesenchymal stem cells cultured under a different environment in ameliorating limb ischemia in allogeneic recipients. [Cardiovasc Res] Abstract

Guidance of In Vitro Migration of Human Mesenchymal Stem Cells and In Vivo Guided Bone Regeneration Using Aligned Electrospun Fibers Scientists tested their hypothesis that cell migration and bone tissue formation can be guided and facilitated by microscale morphological cues presented from a scaffold. [Tissue Eng Part A] Abstract

Allogeneic Human Mesenchymal Stem Cell Therapy (Remestemcel-L, Prochymal) as a Rescue Agent for Severe Refractory Acute GvHD in Pediatric Patients Investigators evaluated the risk/benefit profile of remestemcel-L (Prochymal), a third party, off-the-shelf source of human mesenchymal stem cells, as a rescue agent for treatment-resistant acute graft versus host disease (GvHD) in pediatric patients. [Biol Blood Marrow Transplant] Abstract | Press Release

MSCs vs. MSCs Combined with CB for Engraftment Failure Following Autologous Hematopoietic Stem Cell Transplantation: A Pilot Prospective, Open-Labeled, Randomized Trial Researchers prospectively evaluated the effects and safeties of mesenchymal stem cells (MSCs) alone and combined with cord blood (CB) for engraftment failure. Twenty two patients were randomized to receive MSCs or MSCs plus CB. If patients did not response to MSCs, they would receive the therapeutic schedule in CB group, and those patients with partial response in MSCs group and those without complete response in CB group would continue another cycle of MSCs treatment. [Biol Blood Marrow Transplant] Abstract

Extrahepatic Stem Cells Mobilized from the Bone Marrow by the Supplementation of BCAA Ameliorate Liver Regeneration in an Animal Model Researchers report that liver repopulation could be achieved with hepatocytes that bone marrow derived from stem cells proliferated. The treatment by oral supplementation of beanched-chain amino acids (BCAA) resulted in higher levels of CD34+SDF+c-kit+ stem cells in the blood and liver after liver transplantation. [J Gastroenterol Hepatol] Abstract

A Novel Three-Dimensional Adipose-Derived Stem Cell Cluster for Vascular Regeneration in Ischemic TissueThe authors describe an innovative three-dimensional cell mass (3DCM) culture that is based on cell adhesion (basic fibroblast growth factor-immobilized substrate) and assess the therapeutic potential of 3DCMs composed of human adipose tissue-derived stromal cells. [Cytotherapy] Abstract

Human Salivary Gland Stem Cells Ameliorate Hyposalivation of Radiation-Damaged Rat Salivary Glands Researchers isolated tissue-specific stem cells from the human submandibular salivary gland (hSGSCs). Transplantation of hSGSCs to radiation-damaged rat salivary glands rescued hyposalivation and body weight loss, restored acinar and duct cell structure, and decreased the amount of apoptotic cells. [Exp Mol Med] Abstract | Full Article

Continued here:
CellTherapyNews — Cell Therapy News Home

Comments are closed.