ABCA7, a minor gene variant in whites, is major player in African-Americans

Newswise NEW YORK African-Americans with a variant of the ABCA7 gene have almost double the risk of developing late-onset Alzheimers disease compared with African-Americans who lack the variant. The largest genome-wide search for Alzheimers genes in the African-American community, the study was undertaken by the Alzheimers Disease Genetics Consortium and led by neurologists from Columbia University Medical Center. It will be published in the April 10 issue of the Journal of the American Medical Association. The study was primarily funded by the National Institutes of Health (NIH).

Our findings strongly suggest that ABCA7 is a definitive genetic risk factor for Alzheimers disease among African-Americans, said study senior author, Richard Mayeux, MD, MS, professor and chair of Neurology at CUMC. Until now, data on the genetics of Alzheimers in this patient population have been extremely limited.

The ABCA7 gene is involved in the production of cholesterol and lipids, which suggests that lipid metabolism may be a more important pathway in Alzheimers disease in African-Americans than in whites. Because cholesterol and lipid imbalances (which eventually lead to vascular disease and heart attacks and strokes) are more common in African-Americans, treatments that reduce cholesterol and vascular disease may potentially be an effective way to reduce or delay Alzheimers in this population.

While we need to conduct research to determine whether reducing cholesterol will lower the chance of Alzheimers in African-Americans, maintaining healthy cholesterol levels always has the benefit of lowering ones risk of heart attack and stroke, said Dr. Mayeux.

The study involved nearly 6,000 African-American participants, most of whom are volunteers from 18 NIH-funded Alzheimers Disease Centers. The Centers and other researchers contributed samples to the Alzheimers Disease Genetics Consortium, an NIH-supported research program led by Gerard D. Schellenberg, PhD, at the University of Pennsylvania. Approximately 2,000 of the volunteers were diagnosed with probable Alzheimers disease and 4,000 were cognitively normal. The purpose of the study was to look for genetic variants among African-Americans, who are known to have a higher incidence of late-onset Alzheimers than whites living in the same community. Ninety percent of all cases of Alzheimers, which affect an estimated 5 million Americans aged 65 and older, are described as having the late-onset form of the disease.

ABCA7 is the first major gene implicated in late-onset Alzheimers among African Americans, and it has an effect on disease risk comparable to that of APOE-e4which has been known for two decades to be a major genetic risk factor in whites, said Christiane Reitz, MD, PhD, assistant professor of neurology, who conducted the studys genetic analyses as first author on the paper. Both genes raise the risk of Alzheimers in this population twofold. The extent of the role of APOE-e4 in African-Americans had been uncertain because of inconsistent results from previous, smaller studies.

Based on these results, we now know that both APOE-e4 and ABCA7 are major genetic risk factors for African-Americans, whereas for whites, only one of the twoAPOE-e4confers a similar degree of risk, said Dr. Mayeux, who is also co-director of the Taub Institute for Research on Alzheimers Disease and the Aging Brain and the Gertrude H. Sergievsky Center at CUMC. He is the Gertrude H. Sergievsky Professor of Neurology, Psychiatry and Epidemiology.

Several other genes that had recently been linked to Alzheimers in white populations were also confirmed in the current study to play a role in African-Americans. Because they cross ethnic groups, the likelihood increases that these genes are very important in the development of Alzheimers, said Dr. Reitz, who is a member of both the Sergievsky Center and the Taub Institute. And that gives us clues in our search for the cellular pathways associated with the disease.

These findings suggest that the genetic underpinnings of Alzheimers disease may vary among different populationsand so should not be treated homogeneously, said Dr. Reitz.

See the rest here:
Gene Linked to Nearly 2x Alzheimer's Risk in African-Americans

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