MOUNTAIN VIEW, CALIF. In Silicon Valley, the line between computing and biology has begun to blur in a way that could have enormous consequences for human longevity.

Bill Banyai, an optical physicist at Complete Genomics, has helped make that happen. When he began developing a gene sequencing machine, he relied heavily on his background at two computer networking startup companies. His digital expertise was essential in designing a factory that automated and greatly lowered the cost of mapping the three billion base pairs that form the human genome.

The promise is that low-cost gene sequencing will lead to a new era of personalized medicine, yielding new approaches for treating cancers and other serious diseases. The arrival of such cures has been glacial, however, although the human genome was originally sequenced more than a decade ago.

Now that is changing, in large part because of the same semiconductor industry manufacturing trends that opened up consumer devices such as the PC and the smartphone: exponential increases in processing power and transistor density are accompanied by costs that fall at an accelerating rate.

As a result, both new understanding and new medicines will arrive at a quickening pace, according to the biologists and computer scientists.

For all of human history, humans have not had the readout of the software that makes them alive, said Larry Smarr, director of the California Institute of Telecommunications and Information Technology, a research centre that is jointly operated by the University of California, San Diego, and the University of California, Irvine.

Once you make the transition from a data poor to data rich environment, everything changes, said Smarr, who is a member of the Complete Genomics scientific advisory board.

Complete Genomics, based in Mountain View, is one of more than three dozen firms hastening to push the cost of sequencing an entire human genome below $1,000. The challenge is part biology, part chemistry, part computing, and in Complete Genomics case, part computer networking.

Complete Genomics is a classic Silicon Valley startup story. Even the gene sequencing machines, which are housed in a 4,000-square-foot room bathed in an eerie blue light, appear more like a traditional data centre than a biology lab.

In 2005, when Clifford Reid, a successful Silicon Valley software entrepreneur, began to assemble his team, he approached Banyai and asked if he was interested in joining a gene sequencing startup. Reid, who was also trained in physics and math, had spent a year as an entrepreneur-in-residence at the Massachusetts Institute of Technology, where he had become a convert to bioinformatics, the application of computer science and information technologies to biology and medicine.

The rest is here:
Gene sequencing falls to $5,000

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