Video Link: https://www.youtube.com/watch?v=08rWaqewyN4

06-06-2012 19:15 A research team led by Dr. Seung Hoon Lee took part in a multinational genome research project, consisting of researchers from fifty different nations. The project's findings identifying 56 genes involved in osteoporosis and fracture risk were published on April16th in Nature Genetics. In the largest-scale genetic research project to date, genetic testing was done on 210000 individuals from around the world. The study included clinical data from Korea, such as bone density measures and DNA samples from fourteen hundred patients. The study was able to identify 56 genetic variants, including WNT16, that influence bone density, of which 14 were associated with fracture risk. Dr. Seung Hoon Lee / Dept. of Endocrinology/Metabolism If individuals with high fracture risk can be identified by detecting this kind of high-risk gene, in addition to other clinical risk factors and bone density measurements in accordance with current treatment standards, the study suggests that prevention and treatment using individually-tailored drugs will be possible. Osteoporosis is a skeletal disease of increased risk of fracture due to weakened bone strength. Although this age-related disease is silent and asymptomatic until fractures occur, it has a high incidence and devastating consequences. By identifying genes related to osteoporosis and fracture risk, this multinational genetic study is expected to lead to new breakthroughs in the treatment of osteoporosis.

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Genes associated with osteoporosis and fracture risk identified - Video

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