By Jim Dryden - Part of the risk for alcohol dependence is genetic, and the same is true for eating disorders. Now, researchers at Washington University School of Medicine in St. Louis have found its likely some of the same genes are involved in both.

In clinical practice, its been observed that individuals with eating disorders also have high rates of alcohol abuse and dependence, said Melissa A. Munn-Chernoff, PhD, the studys first author. Other studies have focused on the genetic connections between alcohol dependence and eating disorders, but all of those studies looked only at women. Ours was the first to include men as well.

According to Munn-Chernoff, a postdoctoral research scholar in psychiatry, thats important because although eating disorders tend to be thought of as a female problem, they affect men, too.

By studying twins, the researchers used statistical methods to determine the odds that certain traits result from the same genes. Those statistical insights are based on the fact that identical twins share 100 percent of their genetic makeup while fraternal twins share about half.

By comparing the findings in identical and fraternal twins, we can develop estimates of how much of the difference in particular traits is due to genes or environment, Munn-Chernoff explained. We found that some of the genes that influence alcohol dependence also influence binge eating in men and women.

Even with the growing awareness and more frequent diagnoses of problems such as anorexia nervosa and bulimia nervosa, rates of the full-blown forms of these disorders are relatively low, and theyre rare in populations of twins. So the researchers surveyed study subjects about whether they suffered from eating-disorder symptoms.

The symptoms can cut across multiple eating disorder diagnoses, said Munn-Chernoff. And several past studies have suggested that the particular behavior of binge eating, as well as purging and other practices that we call compensatory behaviors, may be closely associated with alcohol dependence, which is why we focused on those symptoms.

All of the men and women in the study were surveyed about their alcohol use and binge eating, but because the researchers were analyzing data that had been gathered previously for a different study, not everyone was asked about compensatory behaviors, such as purging or using laxatives and diuretics. Only the female twins were asked about those symptoms.

In all, nearly 25 percent of the men and 6 percent of women had been alcohol dependent at some point. Almost 11 percent of these same men and 13 percent of the women had experienced problems with binge eating. In addition, about 14 percent of the women had engaged in purging or abuse of laxatives or diuretics.

On a statistical scale that runs from zero (no shared genes) to 1 (all genes shared), the researchers found that the genetic correlation between binge eating and alcohol dependence was statistically significant at .26.

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Genetic Link Between Alcohol Abuse and Eating Disorders

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