Newswise Bethesda, MDOctober 1, 2012 Listed below are the selected highlights for the October 2012 issue of the Genetics Society of Americas journal, GENETICS. The October issue is available online at http://www.genetics.org/content/current. Please credit GENETICS, Vol. 192, October 2012, Copyright 2012.

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ISSUE HIGHLIGHTS

Energy-dependent modulation of glucagon-like signaling in Drosophila via the AMP-activated protein kinase, pp. 457466 Jason T. Braco, Emily L. Gillespie, Gregory E. Alberto, Jay E. Brenman, and Erik C. Johnson How organisms maintain energetic homeostasis is unclear. These authors show that the actions of a known cellular sensor of energythe AMP-activated protein kinase (AMPK)cause release of a glucagon-like hormone in Drosophila. They further show that AMPK regulates secretion of adipokinetic hormone. This suggests new roles and targets for AMPK and suggests metabolic networks are organized similarly throughout Metazoa.

The relation of codon bias to tissue-specific gene expression in Arabidopsis thaliana, pp. 641649 Salvatore Camiolo, Lorenzo Farina, and Andrea Porceddu This article reports systematic differences in usage of synonymous codons in Arabidopsis thaliana genes whose expression is tissue specific. The authors propose that codon bias evolves as an adaptive response to the different abundances of tRNAs in different tissues. Integrity and function of the Saccharomyces cerevisiae spindle pole body depends on connections between the membrane proteins Ndc1, Rtn1, and Yop1, pp. 441455 Amanda K. Casey, T. Renee Dawson, Jingjing Chen, Jennifer M. Friederichs, Sue L. Jaspersen, and Susan R. Wente Budding yeast face an unusual challenge during cell division: they must segregate their chromosomes while the nuclear envelope remains intact. Consequently, mitosis begins with insertion of the duplicated spindle pole body (a.k.a. centrosome) into the nuclear envelope, a process that parallels the generation of new nuclear pore complexes. These authors report data that suggest new mechanisms for linking nuclear division and transport.

Cellular memory of acquired stress resistance in Saccharomyces cerevisiae, pp. 495505 Qiaoning Guan, Suraiya Haroon, Diego Gonzlez Bravo, Jessica L. Will, and Audrey P. Gasch Cells can retain memory of prior experiences that influence future behaviors. Here, the authors show that budding yeast retains a multifaceted memory of prior stress treatment. Cells pretreated with salt retain peroxide tolerance for several generations after removal of the initial stressor. This is due to long-lived catalase, produced during salt treatment and distributed to daughter cells. These cells also display transcriptional memory dependent on the nuclear pore subunit Nup42 that functions to promote reacquisition of stress tolerance in future stress cycles.

Genomic variation in natural populations of Drosophila melanogaster, pp. 533598 Charles H. Langley, Kristian Stevens, Charis Cardeno, Yuh Chwen G. Lee, Daniel R. Schrider, John E. Pool, Sasha A. Langley, Charlyn Suarez, Russell B. Corbett-Detig, Bryan Kolaczkowski, Shu Fang, Phillip M. Nista, Alisha K. Holloway, Andrew D. Kern, Colin N. Dewey, Yun S. Song, Matthew W. Hahn, and David J. Begun This article greatly extends studies of population genetic variation in natural populations of Drosophila melanogaster, which have played an important role in the development of evolutionary theory. The authors describe genome sequences of 43 individuals taken from two natural populations of D. melanogaster. The genetic polymorphism, divergence, and copy-number variation revealed in these data are presented at several scales, providing unprecedented insight into forces shaping genome polymorphism and divergence.

Estimating allele age and selection coefficient from time-serial data, pp. 599607 Anna-Sapfo Malaspinas, Orestis Malaspinas, Steven N. Evans, and Montgomery Slatkin The relative importance of the four fundamental processes driving evolutiongenetic drift, natural selection, migration, and mutationremains undetermined. These authors propose a new approach to estimate the selection coefficient and the allele age of time serial data. They apply their methodology to ancient sequences of a horse coat color gene and demonstrate that the causative allele existed as a rare segregating variant prior to domestication. This illuminates the debate on the relative importance of new vs. standing variation in adaptation and domestication. DNA replication origin function is promoted by H3K4 di-methylation in Saccharomyces cerevisiae, pp. 371384 Lindsay F. Rizzardi, Elizabeth S. Dorn, Brian D. Strahl, and Jeanette Gowen Cook What defines a DNA replication origin? It is becoming increasingly apparent that post-translational modifications of nucleosomes near replication origins help mark them and control their activity. The genetic analysis presented in this article implicates di-methylated histone H3 lysine 4 (stimulated by histone H2B monoubiquitination) as part of the definition of active replication origins. Since these histone modifications are highly conserved, these findings are relevant to genome organization in other eukaryotes.

Comparative oncogenomics implicates the Neurofibromin 1 gene (NF1) as a breast cancer driver, pp. 385396 Marsha D. Wallace, Adam D. Pfefferle, Lishuang Shen, Adrian J. McNairn, Ethan G. Cerami, Barbara L. Fallon, Vera D. Rinaldi, Teresa L. Southard, Charles M. Perou, and John C. Schimenti This study of a mouse model of genomic instability indicates that NF1 (Neurofibromin 1) deficiency can drive breast cancer. ~ 63,000 people in the United States annually will develop breast cancer with an NF1 deficiency. Together with evidence that NF1 depletion confers resistance of human breast cancer cells to tamoxifen, these findings suggest therapeutic strategies for patients with NF1-deleted tumors.

ABOUT GENETICS: Since 1916, GENETICS (http://www.genetics.org/) has covered high quality, original research on a range of topics bearing on inheritance, including population and evolutionary genetics, complex traits, developmental and behavioral genetics, cellular genetics, gene expression, genome integrity and transmission, and genome and systems biology. GENETICS, a peer-reviewed, peer-edited journal of the Genetics Society of America is one of the world's most cited journals in genetics and heredity.

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GENETICS Journal Highlights for October 2012

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