ACGT is the only public charity in the nation exclusively funding cancer cell and gene therapy research. By supporting research in discovery and translational research, we stimulate both innovation and progress.

2014 Young Investigator Award, Posted: August 27, 2014 Abstract Deadline: September 16, 2014 at 4 pm E.S.T. Invitation to Submit Application: October 10, 2014 Deadline for Completed Application: November 6, 2014at1 pm E.S.T.

View the RFA (pdf) here.

All applications are to be uploaded atAltum Proposal Central.

The Investigators Award in Clinical Translation of Gene Therapy for Cancer distributes funds over 3-5 years, inclusive of a maximum of 10% indirect costs. Funds may be used at the recipients discretion for salary, technical assistance, supplies, animals or capital equipment, but may not support staff not directly related to the project, e.g. secretaries or administrative assistants. Purchase of equipment is not allowed in the final year of the grant.

A number of cell and gene therapy approaches for cancer have been shown to be efficacious and safe in laboratory animal models in the recent years, but their translation into clinical trials has been hindered by a lack of resources. Recognizing this critical need, ACGT is accepting grant applications to produce and release-testing of the clinical trial agents under cGMP, conduct the necessary pre-clinical pharmacological and toxicological studies in appropriate animal models, and/or conducting the clinical translational trials in patients in support of an Investigative New Drug (IND) application to the FDA. While the unambiguous demonstration of preclinical efficacy in cancer treatment by cell and gene therapy is a pre-requisite, entering into the clinical trial during the funding period is also a requirement. Applications that do not include this specific aim will be deemed unresponsive to the RFA.

Candidates must hold an MD, PhD, or equivalent degree and be a tenure-track or tenured faculty. The investigator must be conducting original research as an independent faculty member. ACGT has no citizenship restrictions; however, research supported by the award must be conducted at medical schools and research centers in the United States and Canada. Entering into clinical translation during the funding period is a requirement. Continued support is contingent upon submission and approval of a non-competitive renewal application each year.

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