Regulated information December 23, 2013

TiGenix secures EUR 10 million in financing from Kreos Capital Company ends year in strong position to fully leverage leading cell therapy platform

Leuven (BELGIUM) - December 23, 2013 - TiGenix (Euronext Brussels: TIG) announced today that it has signed a structured debt financing agreement of up to EUR10 million with Kreos Capital (Kreos), Europe's largest and leading provider of growth debt to high-growth companies.

The funds will supplement the EUR 12 million in equity financing TiGenix recently secured from Gri-Cel SA, and will be used for general growth purposes as TiGenix advances the development of its expanding pipeline of cell therapy products.

"In combination with the recent strategic investment by Gri-Cel/Grifols this funding significantly strengthens our financial position and allows us to aggressively expand our pipeline of proprietary cell therapy products," said Eduardo Bravo, CEO of TiGenix. "Importantly, it enables us to independently finalize the Phase III trial with our lead product Cx601 and file for European registration, and thus capture significantly more value from a potential partnering agreement. The addition of debt financing represents an attractive and, except for a limited warrant component, non-dilutive complement to our existing capital structure. We are delighted to finish the year with a solid balance sheet and additional resources to optimally leverage our world-leading cell therapy technology platform as we move forward."

"Kreos is very pleased to be able to support TiGenix as it further builds its strong cell therapy portfolio," said Maurizio PetitBon, General Partner of Kreos. "TiGenix constitutes one of our first investments in the public market, and we have been very impressed by the quality of the team, the technology platform and the underlying business."

About the loan agreement Draw down: three tranches at the Company's discretion: EUR 5 million in early February 2014; EUR 2.5 million by end of May, 2014; EUR 2.5 million by end of September, 2014 Term: four years Amortization: starts at first anniversary Interest: 12.5% fixed annual interest rate Structure: security over certain assets; no financial covenants Warrants:approximately 2 million warrants to be granted to Kreos, subject to shareholder approval; exercise price to equal 30-day average closing price of TiGenix share at date of issue of warrants; if shareholders do not approve the issue of warrants, Kreos is entitled to a payment of EUR 890,000 over 3 years

For more information: Eduardo Bravo Chief Executive Officer eduardo.bravo@tigenix.com

Claudia D'Augusta Chief Financial Officer claudia.daugusta@tigenix.com

Hans Herklots Director Investor & Media Relations hans.herklots@tigenix.com +32 16 39 60 97

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TiGenix : TiGenix secures EUR 10 million in financing from.

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