Coronavirus: What are the different types of COVID-19 tests? – Sky News
Posted: September 11, 2020 at 3:59 am
As the government considers plans to carry out mass coronavirus testing, Sky News looks at the different types of tests available.
There are two different strands of testing - one is to find out if a person currently has COVID-19 and the other determines if they have had it and have built up antibodies.
PCR testing and antigen testing (often confused as the same kind of test) are different methods of testing, but both ascertain whether a person has COVID-19 at the time.
PCR testing
Polymerase chain reaction (PCR) testing is currently the most common form of testing in the UK and is seen as fairly reliable.
A swab is used to collect an RNA sample (the nucleic acid that converts DNA into proteins) from the patient's tonsils and inside their nose.
RNA is collected as it carries the genetic information of this specific virus.
This is then sent to a laboratory where the sample is heated and cooled so it multiplies into larger quantities of DNA.
Bioscientists can then see whether the SARS-CoV-2 virus (the virus that causes COVID-19) is present.
Because of the process, PCR tests are taking about two days and are currently only available to people with symptoms, those in households with symptoms, and key workers.
90-minute PCR test
Machines that can deliver on-the-spot genetic testing are being used to collect RNA for PCR testing, which can also detect the common flu.
The RNA, taken using swab samples placed into a cartridge, is inserted into the machine which carries out a PCR test and then identifies if the virus is present.
A successful pilot test across eight London hospitals using British start-up DnaNudge's machines is being rolled out to NHS hospitals, with the plan to deliver 5.8m tests in the next few months.
20-minute saliva test
Loop-mediated Isothermal Amplification (LAMP) is a similar process to PCR testing but produces many more viral RNA copies at a constant temperature instead of heating and cooling.
A swab is used to take samples from the nose or throat, or mucus from hard coughing can also be used.
The samples are then placed in vials of reagents (substances that produce a chemical reaction to detect the RNA), then heated in a special machine for 20 minutes.
The machine then analyses the sample and confirms if there is any SARS-CoV-1 RNA.
Health Secretary Matt Hancock announced on 3 September that the LAMP test would be part of a 500m funding boost after a successful pilot across Hampshire hospitals, GP test hubs and care homes.
No-swab saliva test
Patients can do this test at home by collecting about two millimetres of saliva into a sample pot, then sending it off to a laboratory.
The sample gets tested using LAMP technology in a lab and the result is then texted to the person.
It still takes about 48 hours but there is no need for a patient to leave their home or stick a swab down their throat or up their nose.
A government-funded trial in Southampton has been expanded from GPs to the city's university staff and students, and four schools.
Antigen testing
These tests look for antigens - proteins that are produced by the body when it recognises a foreign structure, such as the COVID-19 virus.
Antigens can easily be detected in saliva and laboratory testing is not necessary, so can be done in places such as care homes and without a medical professional.
Results can be provided more quickly than PCR tests, with some systems already available and dozens more being developed.
20-second test
Released this week, the Virolens system uses a portable machine which creates a microscopic holographic image to detect the virus in saliva samples in 20 seconds.
Developed by British companies iAbra and TT Electronics, it uses a digital camera attached to a microscope, which then runs data through a computer that can identify the virus from other cells.
The device has been trialled at Heathrow Airport, whose chief executive, John Holland-Kaye, has urged the government to fast-track the technology to be used across the UK.
Antibody testing
Not currently available to the general public on the NHS, antibody testing looks at whether your body has produced any antibodies to fight against the virus.
A blood test is taken from a person who has had COVID-19 symptoms that have disappeared three to four weeks before.
A lab test then takes a unique protein the virus makes and tests whether any antibodies in the blood bind to that protein.
There are pin-prick tests in development which would allow a person to submit their own blood test, but these have not been rolled out yet.
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Unlike other diseases, the UK government and the World Health Organisation agree there is currently no evidence that someone with antibodies will not catch COVID-19 again in the future.
This is why the government has not rolled antibody testing out to the general public, although tests are available privately.
NHS staff, care staff and some people in care homes and in hospital are having antibody tests.
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Coronavirus: What are the different types of COVID-19 tests? - Sky News
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