A New York Times story this week about tennis legend Chris Everts battletwicewith ovarian cancer painted a simple and powerful picture: Fearing for her own risk after her sister died of the disease, Evert got tested, caught it early, as stage 1, and treated it successfully in 2022. And though it returnedstage 1 again, meaning it had not spreadshe was able to catch that, too, and treat it again. Now the 69-year-old has been declared cancer-free a second time.

As with her original diagnosis, the story notes, early testing was criticala message Ms. Evert shares zealously.

Except for just one problem: When it comes to ovarian cancer, there is no such thing as early testing.

There is no approved screening. There is no method of early detection, Sarah DeFeo, chief program officer at the Ovarian Cancer Research Alliance (OCRA), tells Fortune. Its a rare disease, with a one-in-87 over-lifetime risk, so its not something that happens as part of a well-woman checkup, whether with a gynecologist or regular internal medicine.

Thats because, says Dr. Gillian Hanley, a member of OCRAs scientific advisory committee and an associate professor of obstetrics and gynecology at the University of British Columbia, all of the screening methods that have been tried have failed to decrease mortality rates to date, which is how we determine whether or not a screening method is effective.

While there are some standard ways of surveilling for ovarian cancer if it is suspectedincluding a CA-125 blood test that could possibly indicate tumor markers and a transvaginal ultrasound that could help identify massesthey are imprecise. Plus, they are not indicated or available to women in the absence of either symptomswhich tend to only reveal themselves once the cancer has progressed significantlyor a high-risk factor, meaning the patient has already tested positive for carrying genetic markers that significantly raise the possibility of getting ovarian cancer.

If youre just a regular, average-risk person walking around in the world, a doctor may be like, [a routine scan is] not medically indicated. Theres no need for that Theres no evidence to suggest that ultrasounds are effective,' says DeFeo. So thats not something that is recommended. Its not neutral its like, No, dont do it.

Instead, what women should consider, she says, is getting tested for genetic markers. Its something Evert has talked about previouslyhaving tested positive for the BRCA-1 gene after her sisters death, then undergoing a preventative hysterectomy with removal of her ovaries and fallopian tubes. It was only then, through the pathology report, that she learned she had stage 1 ovarian cancer (which returned, even after the surgery, due to the fact that microscopic cancer cells can sometimes remain in the abdomen).

None of those details were mentioned in the most recent New York Times articlebut they are actually the most vital, says DeFeo.

She has talked a lot about getting tested early, but to me, the real story is about the importance of knowing your risk and about risk management, she says. I think that thats the important takeaway from her story.

Much of the current wisdom around screening comes out of the disappointing 2021 results of a U.K.-based clinical trial that followed 200,000 women for more than 20 years, concluding that screening and symptom awareness do not save lives.

The trial, which was the largest of its kind in the world, randomized patients into three groups: 1) no screening, 2) annual screening with ultrasound, and 3) annual screening with ultrasound and CA-125 blood test. It found no evidence of lives saved in the groups that were tested. We therefore cannot recommend ovarian cancer screening for the general population using these methods, lead investigator Dr. Usha Menon noted at the time.

This is whats tricky and devastating about ovarian cancer, that it needs to be caught so much earlier, we think, in order for it to impact mortality, says DeFeo. Its not about catching it three months earlier We need to find a way to catch this disease years earlier.

But as of now, thats not possible. The technology doesnt exist, she says. Plus, adds Hanley, most cases of ovarian cancer appear to originate in the fallopian tubeswhich are not easily reached or biopsied.

Its why OCRAs recommendation officially switched last year from symptom awareness and early detection to something else entirely: the preventative removal of ones fallopian tubes, called a salpingectomy. Its an approach that has been endorsed by the American College of Obstetricians and Gynecologists (ACOG) since 2015.

The recommendation applies not only to those who test positive for high genetic risk, such as with BRCA-1 or BRCA-2 gene mutations, but also for all women planning to undergo another pelvic surgery (such as with a hysterectomy, endometriosis, or removal of cysts) if they are finished or not planning on having kids. (For women with the higher risk, an oophorectomy, or prophylactic removal of ovaries, is also recommended.)

So again, were not saying that your regular woman on the street needs to go in and have this elective surgery, says DeFeo. But we know that hundreds of thousands of women are having surgery every year anyway, for a different reason, where they could take the opportunity to take out their tubes at the same time, potentially. Its something that they should talk to their doctor about, and its something that doctors should be thinking about.

Besides salpingectomy, the other most powerful tool in ovarian cancer prevention is genetic testing, which you can begin by looking at your family history. I know that in many families that can be hard, says DeFeo. But to the extent that you can look at your family history, and if you have a family history of cancer, especially breast and ovarian cancers, and especially at a young agethose are red flags.

Hanley adds that it is important to look at both sides of your family. There is a misconception that family history is only relevant on your mothers side, but you can inherit a BRCA mutation from your father as well, she says. So on either side of your family, if there is a history of breast or ovarian cancer, potentially even prostate or pancreatic cancers, then getting a BRCA test is a very good idea.

Then, talk to your doctor about getting it started.

DeFeo notes that genetic testing is more accessible than ever. A lot of insurance covers it. It really depends on each persons situation, but the cost of testing has come down dramatically over the course of the years, she says. So it is increasingly accessible. And OCRA, for example, offers a free genetic testing program.

From there, if you are positive, prophylactic surgeries would be recommended, as was the case with Evert.

She would never have been symptomatic, says Hanley. Theres no screening method that would have picked that up. The only reason that cancer was diagnosed is because her fallopian tubes were removed and then they were very, very carefully analyzed by a pathologistand that doesnt occur outside of the case of a BRCA mutation.

But Hanley, like others in the field, is counting on that to change. Were all hopeful that with technology and better understanding, we may still one day be able to develop a screening method that works, she says. But were a long way away from that.

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Ovarian cancer and Chris Evert: Why early detection doesn't help - Fortune

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