Nanoparticle Therapy Shows Promise With Breast Cancer – UMB News
Posted: January 23, 2020 at 12:48 pm
Researchers at theUniversity of Maryland School of Medicine (UMSOM) developed a new nanoparticle drug formulation that targets a specific receptor on cancer cells and appears to be more effective than a standard nanoparticle therapy currently on the market to treat metastatic breast cancer, according to a study published today in the journal Science Advances. The new DART (decreased, non-specific adhesivity, receptor-targeted) nanoparticles bypass healthy cells and tissues and bind to tumor cells, dispersing evenly throughout the tumor while releasing the chemotherapy drug paclitaxel.
The marketed drug Abraxane, a nanoformulation containing paclitaxel that is currently used to treat women with aggressive breast cancer, is an effective agent, but it was not designed to selectively deliver paclitaxel to only the cancerous cells within the body, said study corresponding co-author Jeffrey Winkles, PhD, a professor of surgery at UMSOM. Our DART nanoparticle specifically targets the Fn14 receptor found abundantly on breast cancer cells; it uses this receptor to gain entry through the plasma membrane and deliver the drug to destroy the cancer. Winkles group discovered the Fn14 receptor and described its potential as a target for new therapeutics more than a decade ago.
For this study, UMSOM researchers engineered and tested a new therapeutic nanoparticle platform to deliver the drug paclitaxel to treat triple-negative breast cancer. About one in five women with breast cancer have this type of aggressive tumor, which is particularly difficult to treat; these cancers lack receptors commonly expressed by most breast cancer cells, like hormone receptors, for which effective drugs have been designed. But many triple-negative breast cancers express high levels of Fn14; indeed, most solid tumor types, including lung, prostate, and colorectal cancer, overexpress this cell surface receptor.
After much initial hype and some disappointments in the field, nanoparticle delivery systems for cancer treatment are starting to show real promise for patients, said study co-author Graeme Woodworth, MD, professor and interim chair in the Department of Neurosurgery at UMSOM. We established a proof-of-concept with this study, outlining the design of an optimized nanoparticle delivery system that balances the specific binding to cancer cells while minimizing non-specific, off-target binding to other cells in a very fine-tuned way.
To accomplish this, the research team attached a monoclonal antibody called ITEM 4 to the surface of the nanoparticle because it specifically binds to Fn14, providing a key to unlock entry into the cancer cell. The surface of the nanoparticles also was coated with polyethylene glycol to keep them circulating through the bloodstream and lymph system until they reached the tumor and to prevent them from being quickly flushed out of the body.
Many drug delivery carriers exhibit non-specific binding to healthy cells and tissues in addition to the diseased cells they are targeting, which often leads to unintended side effects or toxicities, said study corresponding co-author Anthony Kim, PhD, associate professor of neurosurgery and pharmacology at UMSOM. This DART nanoparticle platform has unique capabilities to improve therapeutic delivery to difficult-to-treat locations within the body while also allowing us to potentially increase the maximum tolerated dose of the encapsulated drug without increasing side effects to patients.
The researchers filled their optimized DART nanoparticle formulation with paclitaxel and tested it against Abraxane (the marketed nanoparticle that also contains paclitaxel) in animals with triple-negative breast cancer tumors. In one set of experiments, the nanoparticles were delivered to mice harboring breast tumors grown above the natural breast region. They found the DART formulation led to a significantly increased median overall survival (68 days) compared to Abraxane treatment (45 days). They also saw a clear benefit to using the DART nanoparticles when they compared the treatments again in animals that harbored breast tumors implanted in the brain (akin to a metastatic brain tumor).
This is a compelling finding and significant step forward in the use of nanoparticles to treat cancer, said UMSOM Dean E. Albert Reece, MD, PhD, MBA, the John Z. and Akiko K. Bowers Distinguished Professor and University of Maryland, Baltimore executive vice president for medical affairs. It fits squarely with our School of Medicines mission to advance the field of potentially lifesaving therapies for patients with the most difficult to treat cancers.
The UMSOM researchers are members of the University of Maryland Marlene and Stewart Greenebaum Comprehensive Cancer Center. A former PhD student, Jimena Dancy, PhD, and a former postdoctoral fellow, Aniket Wadajkar, PhD, are listed as co-first authors on the publication. Researchers from the Translational Genomics Research Institute in Phoenix, Ariz., and the Mayo Clinic Arizona in Scottsdale, Ariz., also contributed to the work.
This study was primarily funded by the National Institutes of Health.
Future research includes testing the DART therapy in other cancer types, including an aggressive form of brain cancer called glioblastoma and developing a similar version of the nanoparticle designed to work specifically in humans. This would involve using a humanized antibody on the surface of the nanoparticle and scaling up the formulation. The researchers recently received a grant from the TEDCO Maryland Innovation Initiative Commercialization Program to move forward with efforts to adapt their nanoparticle system and eventually test the treatment in cancer patients.
Read this article:
Nanoparticle Therapy Shows Promise With Breast Cancer - UMB News
- Hormone therapy: Is it right for you? - Mayo Clinic [Last Updated On: May 4th, 2015] [Originally Added On: May 4th, 2015]
- LifeXmd :: Bioidentical Hormone Replacement Therapy Center [Last Updated On: May 4th, 2015] [Originally Added On: May 4th, 2015]
- Bioidentical hormones: Are they safer? - Mayo Clinic [Last Updated On: May 4th, 2015] [Originally Added On: May 4th, 2015]
- Diabetes and Hormone Center of the Pacific [Last Updated On: May 4th, 2015] [Originally Added On: May 4th, 2015]
- Hormone Replacement Clinic | Topeka & Lawrence KS [Last Updated On: May 4th, 2015] [Originally Added On: May 4th, 2015]
- Integrative Health and Hormone Clinic Cedar Rapids, IA [Last Updated On: May 31st, 2015] [Originally Added On: May 31st, 2015]
- Hormone Center - Home [Last Updated On: May 31st, 2015] [Originally Added On: May 31st, 2015]
- How Are Hormones And Anxiety Related? - Calm Clinic [Last Updated On: June 13th, 2015] [Originally Added On: June 13th, 2015]
- Women's Mood & Hormone Clinic / Moms Program | UCSF ... [Last Updated On: July 3rd, 2015] [Originally Added On: July 3rd, 2015]
- Dallas Anti Aging Clinic for Men | Male Hormone ... [Last Updated On: July 3rd, 2015] [Originally Added On: July 3rd, 2015]
- Hormone clinic to open - News Sentinel Story [Last Updated On: July 10th, 2015] [Originally Added On: July 10th, 2015]
- Male Hormone Replacement - Testosterone - The Turek Clinic [Last Updated On: August 1st, 2015] [Originally Added On: August 1st, 2015]
- Bio-Identical Hormones & Women's Services at Dr. Wright's ... [Last Updated On: August 21st, 2015] [Originally Added On: August 21st, 2015]
- HGH Therapy | HGH Clinics | Human Growth Hormone Therapy [Last Updated On: August 24th, 2015] [Originally Added On: August 24th, 2015]
- Long Island Hormone Therapy Clinic NY, Anti-Aging Clinics ... [Last Updated On: September 25th, 2015] [Originally Added On: September 25th, 2015]
- Home - Seattle Hormone Replacement Clinic for Men [Last Updated On: September 25th, 2015] [Originally Added On: September 25th, 2015]
- Medical Weight Loss Clinic of Utah - Hormone Replacement ... [Last Updated On: September 29th, 2015] [Originally Added On: September 29th, 2015]
- What are Hormones? - Hormone Replacement Therapy Denver [Last Updated On: October 4th, 2015] [Originally Added On: October 4th, 2015]
- Human growth hormone (HGH): Does it slow aging? - Mayo Clinic [Last Updated On: October 9th, 2015] [Originally Added On: October 9th, 2015]
- Bioidentical Hormone Replacement Therapy - Amen Clinics [Last Updated On: October 12th, 2015] [Originally Added On: October 12th, 2015]
- HD Medspa & Clinic | Lakeview Neighborhood, Chicago, for ... [Last Updated On: October 18th, 2015] [Originally Added On: October 18th, 2015]
- Denver Hormone Therapy | Denver Hormone Health [Last Updated On: April 8th, 2016] [Originally Added On: April 8th, 2016]
- Bioidentical Hormone Replacement Therapy for Men and Women ... [Last Updated On: April 29th, 2016] [Originally Added On: April 29th, 2016]
- The Endocrine Clinic | Singapore Hormone Specialists [Last Updated On: June 5th, 2016] [Originally Added On: June 5th, 2016]
- San Antonio Natural Hormone Therapy Clinic | Bio-Identical ... [Last Updated On: June 16th, 2016] [Originally Added On: June 16th, 2016]
- Does hormone replacement medication ... - Lindora Clinic [Last Updated On: June 30th, 2016] [Originally Added On: June 30th, 2016]
- FEMME CLINIQUE - Bio-Identical Hormone Therapy Clinic ... [Last Updated On: June 30th, 2016] [Originally Added On: June 30th, 2016]
- Dr Colin Holloway | Managing hormone imbalances [Last Updated On: July 2nd, 2016] [Originally Added On: July 2nd, 2016]
- melatonin hormone - University of Maryland Medical Center [Last Updated On: July 7th, 2016] [Originally Added On: July 7th, 2016]
- Human chorionic gonadotropin - Wikipedia, the free ... [Last Updated On: July 20th, 2016] [Originally Added On: July 20th, 2016]
- Talk to Nurse Rita - Health, Nursing & Clinic Matters [Last Updated On: July 24th, 2016] [Originally Added On: July 24th, 2016]
- NATESTO (testosterone) Nasal Gel CIII | Prescriber Site [Last Updated On: August 24th, 2016] [Originally Added On: August 24th, 2016]
- Home : Cleveland Clinic Journal of Medicine [Last Updated On: September 18th, 2016] [Originally Added On: September 18th, 2016]
- Ageing - Wikipedia, the free encyclopedia [Last Updated On: September 21st, 2016] [Originally Added On: September 21st, 2016]
- Melatonin - Wikipedia, the free encyclopedia [Last Updated On: September 24th, 2016] [Originally Added On: September 24th, 2016]
- Hormone Replacement Clinic in NJ | Healthy Aging Medical ... [Last Updated On: October 11th, 2016] [Originally Added On: October 11th, 2016]
- UT Southwestern, Dallas, Texas - UTSW Medicine (Patient ... [Last Updated On: October 15th, 2016] [Originally Added On: October 15th, 2016]
- Clinical Guidelines and Recommendations | Agency for ... [Last Updated On: November 15th, 2016] [Originally Added On: November 15th, 2016]
- Hormone Replacement Therapy | Born Clinic [Last Updated On: November 22nd, 2016] [Originally Added On: November 22nd, 2016]
- Medical Weight Loss | Endocrinology & Hormone Replacement [Last Updated On: November 25th, 2016] [Originally Added On: November 25th, 2016]
- West Coast Womens Clinic - Vancouver Womens Health Clinic [Last Updated On: November 28th, 2016] [Originally Added On: November 28th, 2016]
- Prolactin - Wikipedia [Last Updated On: December 11th, 2016] [Originally Added On: December 11th, 2016]
- Worrying about Anti Mullerian Hormones? | Baby Hopeful [Last Updated On: December 19th, 2016] [Originally Added On: December 19th, 2016]
- Risk of Pregnancy Loss in Subclinical Hypothyroidism - Endocrinology Advisor [Last Updated On: February 7th, 2017] [Originally Added On: February 7th, 2017]
- Public invited to women's clinic opening in New Albany - Evening News and Tribune [Last Updated On: February 7th, 2017] [Originally Added On: February 7th, 2017]
- Thyroid Hormone Therapy for Subclinical Hypothyroidism in Pregnancy - Medical News Bulletin [Last Updated On: February 7th, 2017] [Originally Added On: February 7th, 2017]
- Transgender youth in Alberta need more than 1 part-time clinic, says new campaign - CBC.ca [Last Updated On: February 7th, 2017] [Originally Added On: February 7th, 2017]
- BRUCKNER: UNL a national model for trans, LGBT care - Daily Nebraskan [Last Updated On: February 8th, 2017] [Originally Added On: February 8th, 2017]
- Hospital in Somerset becomes first in NJ to open LGBTQ health center - New Jersey 101.5 FM Radio [Last Updated On: February 8th, 2017] [Originally Added On: February 8th, 2017]
- Four NIH-backed projects aim to advance the artificial pancreas - MobiHealthNews [Last Updated On: February 10th, 2017] [Originally Added On: February 10th, 2017]
- In Transition: Physical transitions can include hormone treatment, surgery - The Baylor Lariat [Last Updated On: February 10th, 2017] [Originally Added On: February 10th, 2017]
- Amphetamine use may 'speed up' heart aging - Medical News Today [Last Updated On: February 11th, 2017] [Originally Added On: February 11th, 2017]
- Nationwide Planned Parenthood protests energize patients, opponents - SFGate [Last Updated On: February 11th, 2017] [Originally Added On: February 11th, 2017]
- Women's wellness: Understanding hypothyroidism and pregnancy - The Killeen Daily Herald [Last Updated On: February 12th, 2017] [Originally Added On: February 12th, 2017]
- How This Police Officer Is Helping Trans Patients Get Better Care - Refinery29 [Last Updated On: February 13th, 2017] [Originally Added On: February 13th, 2017]
- Most cases of thyroid cancer are curable - Post-Bulletin [Last Updated On: February 13th, 2017] [Originally Added On: February 13th, 2017]
- Is hormone melatonin the link between sleep and breast cancer? - Knowridge Science Report [Last Updated On: February 15th, 2017] [Originally Added On: February 15th, 2017]
- In West Africa, clinics confront suspicion, and husbands, one IUD at a time - STAT [Last Updated On: February 15th, 2017] [Originally Added On: February 15th, 2017]
- 'Speed' and other recreational stimulants tied to heart damage - Fox News [Last Updated On: February 16th, 2017] [Originally Added On: February 16th, 2017]
- Research shows balancing hormones can aid weight loss - WLS-TV [Last Updated On: February 18th, 2017] [Originally Added On: February 18th, 2017]
- These transgender patients now have a place to change their lives all at once - Miami Herald [Last Updated On: February 20th, 2017] [Originally Added On: February 20th, 2017]
- Healthy eating, the Hyman way - Durham Herald Sun [Last Updated On: February 21st, 2017] [Originally Added On: February 21st, 2017]
- Balancing hormones and weight loss - UPMatters.com [Last Updated On: February 23rd, 2017] [Originally Added On: February 23rd, 2017]
- Have You Heard of These 5 Heart Attack Risk Factors? - Health Essentials from Cleveland Clinic (blog) [Last Updated On: February 23rd, 2017] [Originally Added On: February 23rd, 2017]
- Feeling stressed? Try these proven methods for chilling out - Los Angeles Times [Last Updated On: February 23rd, 2017] [Originally Added On: February 23rd, 2017]
- Mother & Son Swap Sexes At The Same Time! - Radar Online [Last Updated On: February 23rd, 2017] [Originally Added On: February 23rd, 2017]
- The truth about why some men get sleepy after sex | Fox News - Fox News [Last Updated On: February 25th, 2017] [Originally Added On: February 25th, 2017]
- Wellness experts use hormone balancing to fight obesity - WNDU-TV [Last Updated On: February 25th, 2017] [Originally Added On: February 25th, 2017]
- These transgender patients now have a place to change their lives all at once - San Angelo Standard Times [Last Updated On: February 25th, 2017] [Originally Added On: February 25th, 2017]
- Obese couples may take longer to conceive - Fox News [Last Updated On: March 1st, 2017] [Originally Added On: March 1st, 2017]
- Even More Reason to Kick That Sedentary Lifestyle - LifeZette [Last Updated On: March 1st, 2017] [Originally Added On: March 1st, 2017]
- What Happens When Your Immune System Gets Stressed Out? - Health Essentials from Cleveland Clinic (blog) [Last Updated On: March 1st, 2017] [Originally Added On: March 1st, 2017]
- Boutique Egg Freezing Clinics Are the Latest Trend for Those Looking to Delay Parenthood - Babble (blog) [Last Updated On: March 2nd, 2017] [Originally Added On: March 2nd, 2017]
- Municipal Hospital System Opens NYC's First Public Clinic Offering Gender-Reassignment Surgery - NY1 [Last Updated On: March 2nd, 2017] [Originally Added On: March 2nd, 2017]
- Walking has many Health Benefit - Plainview Daily Herald [Last Updated On: March 3rd, 2017] [Originally Added On: March 3rd, 2017]
- Isoflavones in food associated with reduced mortality for women with some breast cancers - Tufts Now [Last Updated On: March 6th, 2017] [Originally Added On: March 6th, 2017]
- Planned Parenthood New York Now Offers Transgender Hormone Replacement Therapy - The Mary Sue [Last Updated On: March 6th, 2017] [Originally Added On: March 6th, 2017]
- Doctor Allie International Hormone Success Doctor Joins the ... - Satellite PR News (press release) [Last Updated On: March 6th, 2017] [Originally Added On: March 6th, 2017]
- Hormone Therapy Clinic | Human Growth Hormone ... [Last Updated On: March 6th, 2017] [Originally Added On: March 6th, 2017]
- Dubai clinic offering free fertility tests for women throughout March ... - Emirates 24|7 [Last Updated On: March 8th, 2017] [Originally Added On: March 8th, 2017]