The association between endothelial dysfunction and late onset hypogonadism (LOH) in patients with vasculogenic erectile dysfunction (ED) is not yet well settled. Our objective was to assess the association between LOH and endothelial dysfunction in patients with vasculogenic ED. Throughout 2014-2015 a total of 90 men were enrolled in this cross-sectional observational study. Of them 60 patients with a clinical diagnosis of ED were further subdivided into two equal groups: patients with vasculogenic ED and LOH (A); patients with vasculogenic ED and euogonadal (B). Thirty age-matched men with no ED or hypogonadism were enrolled as control group (C). All patients were subjected to detailed medical and sexual history, total testosterone (TT), calculated free (FT) and bioavailable testosterone (BT), flow cytometric evaluation for endothelial progenitor cells (EPCs) (CD45negative/CD34positive/CD144positive) and endothelial microparticles (EMPs) (CD45negative/CD144positive/annexin V positive). The mean age SD of the three groups A, B and C were 51.311.1, 53.610.6 and 48.35years, respectively, with insignificant age differences (p=0.089). The diagnostic criteria of LOH were adapted according to European male aging study, 2010. The means of TT(ng/mL) were 2.320.21, 6.430.36 and 5.370.30 in groups A, B and C, respectively. There were highly significant differences between group A and groups B and C (p<0.001 for each). The means of EPCs were 0.430.070, 0.220.05 and 0.0320.013 in groups A, B and C, respectively. The means of EMPs were 0.150.029, 0.056 .013 and 0.0140.002 in groups A, B and C, respectively. There were significant differences between group C and groups A and B (p<0.05 for each). This study clearly demonstrated that there is a significant association between LOH and the higher expression of EPCs and EMPs in patients with vasculogenic ED.

Andrology. 2017 May [Epub]

Y A Omar, S E Younis, I Y Ismail, A I El-Sakka

Department of Urology, Suez Canal University, Ismailia, Egypt., Department of Clinical Pathology, Suez Canal University, Ismailia, Egypt.

PubMed http://www.ncbi.nlm.nih.gov/pubmed/28409902

Excerpt from:
Testosterone level and endothelial dysfunction in patients with vasculogenic erectile dysfunction. - UroToday

Comments are closed.