Report by Mott Center researchers named NIEHS Extramural Paper of the Month – The South End
Posted: October 27, 2021 at 1:44 am
The National Institutes of Environmental Health Sciences has selected a study published by Wayne State University School of Medicine researchers as an Extramural Paper of the Month.
The paper, Paternal preconception phthalate exposure alters sperm methylome and embryonic programming, published in in the October issue of the journal Environment International by J. Richard Pilsner, Ph.D., professor and Robert J. Sokol, M.D., Endowed Chair of Molecular Obstetrics and Gynecology, and director of Molecular Genetics and Infertility for the C.S. Mott Center for Human Growth and Development; and Stephen Krawetz, Ph.D., the Charlotte B. Failing Professor of Fetal Therapy and Diagnosis, and associate director of the Mott Center, was selected by the NIEHS as a paper of the month for September.
The Extramural Papers of the Month are selected based on their important findings and potential for public health impact.
The researchers reported that male mice exposed to phthalates before conception had DNA methylation changes in sperm, which can be transferred to the next generation as altered gene expression in embryos. DNA methylation occurs when a chemical compound, called a methyl group, attaches to DNA, affecting whether a gene is turned on or off.
They exposed male mice to either a low or high level of di(2-ethylhexyl) phthalate for two sperm production cycles, or 67 days. Following exposure, they mated the mice with unexposed females. They then assessed genome-wide methylation in sperm, embryos and extra-embryonic tissues, which support the developing embryo.
Compared with unexposed controls, paternal preconception DEHP exposure altered methylation in 704 sperm gene regions, 1,716 embryo gene regions, and 3,181 extra-embryonic gene regions. Of these, 29 gene regions overlapped between sperm and embryonic tissues, suggesting methylation changes related to paternal DEHP exposure may be transmitted to the next generation. The researchers also identified changes in gene expression in embryos in both exposure groups compared with controls. Many of the altered genes were related to pathways important in development.
The researchers said their results indicate that preconception is a sensitive window in which phthalate exposure alters sperm methylation and embryo gene expression in ways that may influence offspring health and development.
Others involved in the research and subsequent publication include Oladele Oluwayiose, a doctoral student at the University of Massachusetts Amherst; Chelsea Marcho, Department of Environmental Health Sciences, University of Massachusetts Amherst; Haotian Wu, Department of Environmental Health Sciences, Mailman School of Public Health, Columbia University; Alexander Suvorov, Department of Environmental Health Sciences, University of Massachusetts Amherst; Emily Houle, Department of Environmental Health Sciences, University of Massachusetts Amherst; and Jesse Mager, Department of Veterinary and Animal Sciences, University of Massachusetts Amherst.
See the article here:
Report by Mott Center researchers named NIEHS Extramural Paper of the Month - The South End
- HitXP Science of Genetics behind the Hindu Gotra System ... [Last Updated On: May 4th, 2015] [Originally Added On: May 4th, 2015]
- Size Genetics - Male Enhancement Reviews [Last Updated On: May 4th, 2015] [Originally Added On: May 4th, 2015]
- Male Infertility | Genetic Abnormalities or Male ... [Last Updated On: May 4th, 2015] [Originally Added On: May 4th, 2015]
- Male infertility - Wikipedia, the free encyclopedia [Last Updated On: May 4th, 2015] [Originally Added On: May 4th, 2015]
- Androgenic alopecia - Wikipedia, the free encyclopedia [Last Updated On: May 7th, 2015] [Originally Added On: May 7th, 2015]
- Difference Between Male and Female BirdsGenetics and ... [Last Updated On: May 7th, 2015] [Originally Added On: May 7th, 2015]
- URNotAlone Profile for Lynda Flores, Genetic Male Straight ... [Last Updated On: May 21st, 2015] [Originally Added On: May 21st, 2015]
- Understanding Genetics [Last Updated On: May 31st, 2015] [Originally Added On: May 31st, 2015]
- Male - Wikipedia, the free encyclopedia [Last Updated On: May 31st, 2015] [Originally Added On: May 31st, 2015]
- WHO | Gender and Genetics [Last Updated On: May 31st, 2015] [Originally Added On: May 31st, 2015]
- The Genetics of Male Infertility - The Turek Clinic [Last Updated On: June 13th, 2015] [Originally Added On: June 13th, 2015]
- Male Hair Loss All You Need To Know - The Belgravia Centre [Last Updated On: June 29th, 2015] [Originally Added On: June 29th, 2015]
- Male-pattern hair loss - Wikipedia, the free encyclopedia [Last Updated On: August 1st, 2015] [Originally Added On: August 1st, 2015]
- Genetics - biology [Last Updated On: August 2nd, 2015] [Originally Added On: August 2nd, 2015]
- Are People Born Gay? Genetics and Homosexuality [Last Updated On: August 20th, 2015] [Originally Added On: August 20th, 2015]
- Hormone and genetic study in male to female transsexual ... [Last Updated On: September 21st, 2015] [Originally Added On: September 21st, 2015]
- Cloning Myths - Learn Genetics [Last Updated On: September 25th, 2015] [Originally Added On: September 25th, 2015]
- Sensorineural deafness and male infertility - Genetics ... [Last Updated On: October 17th, 2015] [Originally Added On: October 17th, 2015]
- Workable male sterility systems for hybrid rice: Genetics ... [Last Updated On: October 22nd, 2015] [Originally Added On: October 22nd, 2015]
- Proband - Wikipedia, the free encyclopedia [Last Updated On: October 26th, 2015] [Originally Added On: October 26th, 2015]
- Y chromosome - Genetics Home Reference [Last Updated On: October 29th, 2015] [Originally Added On: October 29th, 2015]
- Genetics - NHS Choices [Last Updated On: November 1st, 2015] [Originally Added On: November 1st, 2015]
- Genetics / Does the male or female carrier the gene for twins. [Last Updated On: March 13th, 2016] [Originally Added On: March 13th, 2016]
- The Genetics of Balding | Understanding Genetics [Last Updated On: April 25th, 2016] [Originally Added On: April 25th, 2016]
- Male Infertility - Genetics & IVF Institute [Last Updated On: May 21st, 2016] [Originally Added On: May 21st, 2016]
- Scientist Explains the Genetics of Male Pattern Baldness [Last Updated On: June 16th, 2016] [Originally Added On: June 16th, 2016]
- Definitions for Terms in Genetics Problems [Last Updated On: August 24th, 2016] [Originally Added On: August 24th, 2016]
- Genetics of human male infertility. [Last Updated On: August 24th, 2016] [Originally Added On: August 24th, 2016]
- BEHAVIORAL GENETICS: THE SCIENCE OF ... - PubMed Central (PMC) [Last Updated On: September 13th, 2016] [Originally Added On: September 13th, 2016]
- Review of the Status of Aquaculture Genetics [Last Updated On: September 13th, 2016] [Originally Added On: September 13th, 2016]
- Genetics of Skin Cancer (PDQ)Health Professional Version [Last Updated On: September 22nd, 2016] [Originally Added On: September 22nd, 2016]
- Genetics of Prostate Cancer (PDQ)Health Professional ... [Last Updated On: September 22nd, 2016] [Originally Added On: September 22nd, 2016]
- Genetics of Breast and Gynecologic Cancers (PDQ)Health ... [Last Updated On: September 28th, 2016] [Originally Added On: September 28th, 2016]
- Evolution - Wikipedia [Last Updated On: October 27th, 2016] [Originally Added On: October 27th, 2016]
- Human - Wikipedia [Last Updated On: November 12th, 2016] [Originally Added On: November 12th, 2016]
- Genetics - Wikipedia [Last Updated On: November 23rd, 2016] [Originally Added On: November 23rd, 2016]
- Beefalo - Wikipedia [Last Updated On: December 4th, 2016] [Originally Added On: December 4th, 2016]
- Drosophila melanogaster - Wikipedia [Last Updated On: December 26th, 2016] [Originally Added On: December 26th, 2016]
- Breast CancerPatient Version - National Cancer Institute [Last Updated On: January 6th, 2017] [Originally Added On: January 6th, 2017]
- Sex - Wikipedia [Last Updated On: January 24th, 2017] [Originally Added On: January 24th, 2017]
- The 44 Chromosome Man | Understanding Genetics [Last Updated On: February 5th, 2017] [Originally Added On: February 5th, 2017]
- Binary thought suppresses identity - The Daily Evergreen [Last Updated On: February 8th, 2017] [Originally Added On: February 8th, 2017]
- Tortoiseshell cat - Wikipedia [Last Updated On: February 8th, 2017] [Originally Added On: February 8th, 2017]
- Entrepreneurship Is Genetic, And South Africa Is The Ideal Environment For Young Entrepreneurs To Thrive - Huffington Post South Africa (blog) [Last Updated On: February 8th, 2017] [Originally Added On: February 8th, 2017]
- Women in Data Science conference highlights female participation in male-dominated field - Daily Free Press (subscription) [Last Updated On: February 11th, 2017] [Originally Added On: February 11th, 2017]
- Male Contraceptives Have A Messy History And A Bright Future - Yahoo News [Last Updated On: February 11th, 2017] [Originally Added On: February 11th, 2017]
- The impact of RABL2B gene (rs144944885) on human male infertility in patients with oligoasthenoteratozoospermia ... - UroToday [Last Updated On: February 11th, 2017] [Originally Added On: February 11th, 2017]
- More Than 200 Baldness-Linked Genetic Markers Found - Yahoo News [Last Updated On: February 21st, 2017] [Originally Added On: February 21st, 2017]
- Can Your Anxiety Impact How Long You Last In Bed? - Men's Health [Last Updated On: February 21st, 2017] [Originally Added On: February 21st, 2017]
- Genetic data show mainly men migrated from the Pontic steppe to Europe 5000 years ago - Phys.Org [Last Updated On: February 21st, 2017] [Originally Added On: February 21st, 2017]
- Men inherit male pattern baldness from their mum's side of the family ... - Metro [Last Updated On: February 21st, 2017] [Originally Added On: February 21st, 2017]
- Experts Are One Step Closer To Predicting A Man's Risk For Hair Loss - Huffington Post [Last Updated On: February 21st, 2017] [Originally Added On: February 21st, 2017]
- Baldness linked to over 280 genes - BioNews [Last Updated On: February 21st, 2017] [Originally Added On: February 21st, 2017]
- Genetic basis for male baldness identified in large-scale study - Medical News Today [Last Updated On: February 21st, 2017] [Originally Added On: February 21st, 2017]
- Genetic data show mainly men migrated from the Pontic steppe to ... - Science Daily [Last Updated On: February 23rd, 2017] [Originally Added On: February 23rd, 2017]
- Thousands of horsemen may have swept into Bronze Age Europe, transforming the local population - Science Magazine [Last Updated On: February 23rd, 2017] [Originally Added On: February 23rd, 2017]
- Cohen wins Gates grant for her new take on male contraception - Cornell Chronicle [Last Updated On: June 23rd, 2017] [Originally Added On: June 23rd, 2017]
- A Florida higher-ed official said women's genetics may be keeping ... - Washington Post [Last Updated On: June 23rd, 2017] [Originally Added On: June 23rd, 2017]
- Florida higher education official said women may earn less than men because of genetics - New York Daily News [Last Updated On: June 23rd, 2017] [Originally Added On: June 23rd, 2017]
- Twins Separated at Birth Reveal Staggering Influence of ... [Last Updated On: June 23rd, 2017] [Originally Added On: June 23rd, 2017]
- Scientific studies favor male miceand that could hurt a lot of humans - Popular Science [Last Updated On: July 1st, 2017] [Originally Added On: July 1st, 2017]
- So Cal mountain lions' low genetic diversity threatens population - Davis Enterprise [Last Updated On: July 1st, 2017] [Originally Added On: July 1st, 2017]
- Horse Tale: Oriental Stallions Dominate Horse DNA, Gene Study Shows - NBCNews.com [Last Updated On: July 1st, 2017] [Originally Added On: July 1st, 2017]
- sex chromosome | genetics | Britannica.com [Last Updated On: July 1st, 2017] [Originally Added On: July 1st, 2017]
- The problematics of genetics and the Aryan issue - The Hindu [Last Updated On: July 3rd, 2017] [Originally Added On: July 3rd, 2017]
- Scientists arming new weapon against dengue, malaria mosquitoes - The Indian Express [Last Updated On: July 3rd, 2017] [Originally Added On: July 3rd, 2017]
- Fertility and Genetics - Affordable High Quality Fertility ... [Last Updated On: July 5th, 2017] [Originally Added On: July 5th, 2017]
- Aryan Invasion May Have Transformed India's Bronze-Age Population - Live Science [Last Updated On: July 6th, 2017] [Originally Added On: July 6th, 2017]
- How Masculinity Can Be Bad For Men's Health - WUNC [Last Updated On: July 6th, 2017] [Originally Added On: July 6th, 2017]
- Nilgiris pale tiger an 'aberrant genetic mutation' - The Hindu [Last Updated On: July 8th, 2017] [Originally Added On: July 8th, 2017]
- Evolution and war: The 'deep roots' theory of human violence - Genetic Literacy Project [Last Updated On: July 8th, 2017] [Originally Added On: July 8th, 2017]
- Hair loss in men: THIS shower habit could be why you're going bald - Express.co.uk [Last Updated On: July 10th, 2017] [Originally Added On: July 10th, 2017]
- Don't Blame Your Mom's Dad for Male Pattern Baldness - Inverse [Last Updated On: July 13th, 2017] [Originally Added On: July 13th, 2017]
- Falling sperm counts are linked to endocrine-disrupting chemicals - MinnPost [Last Updated On: July 31st, 2017] [Originally Added On: July 31st, 2017]
- Should genetic engineering be used as a tool for conservation? - chinadialogue [Last Updated On: July 31st, 2017] [Originally Added On: July 31st, 2017]
- Trinity Researchers Lead Analysis of Portugal and Spain's Genetic History - The University Times [Last Updated On: July 31st, 2017] [Originally Added On: July 31st, 2017]
- Williams Professor Wins Grants to Study Evolutionary Genetics - iBerkshires.com [Last Updated On: July 31st, 2017] [Originally Added On: July 31st, 2017]
- History News of the Week: The Biblical Canaanites' Modern Descendants - New Historian [Last Updated On: July 31st, 2017] [Originally Added On: July 31st, 2017]
- When the male fruit fly gets a headache - Haaretz [Last Updated On: July 31st, 2017] [Originally Added On: July 31st, 2017]
- Genetics LadyFrontbum [Last Updated On: July 31st, 2017] [Originally Added On: July 31st, 2017]