BIG WORDS | "Cell Therapy"
Long Live Hip Hop! BIG WORDS now playing! Tix + full tour at http://www.affrm.com/

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BIG WORDS | "Cell Therapy" - Video

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Stem cell therapy shows promise in repairing brain damage even hours after stroke occurs

Durham, NC Stroke is a major health concern and is a leading cause of death in the United States, according to the Center for Disease Control. Despite significant research efforts, developing treatments that ensure complete recovery for stroke patients poses an extreme challenge, especially when more than a few hours have passed between onset of the stroke and administration of treatment.

However, a new study released today in STEM CELLS Translational Medicine indicates that endothelial precursor cells, which are found in the bone marrow, umbilical cord blood, and as very rare cells in peripheral blood, could make a significant difference for these patients recovery even in the later stages of stroke. In animal studies, the treatment minimized the initial brain injury and helped repair the stroke damage.

Previous studies indicated that stem/progenitor cells derived from human umbilical cord blood (hUCB) improved functional recovery in stroke models, noted Branislava Janic, Ph.D., a member of Henry Ford Health Systems Cellular and Molecular Imaging Laboratory in Detroit and lead author of the study. We wanted to examine the effect of hUCB-derived AC133+ endothelial progenitor cells (EPCs) on stroke development and resolution in rats.

Dr. Janic and his team injected rats that had suffered strokes with the stem cells. When they later examined the animals using MRI, they found that the transplanted cells had selectively migrated to the injured area and that the stem cells stopped the tissue damage from spreading, instigated regeneration, and also affected the time course for stroke resolution. A significant decrease in lesion size also was observed, at a dose of 10 million cells, as early as seven days after the strokes onset.

This led us to conclude that cord blood-derived EPCs can significantly contribute to developing more effective treatments that allow broader time period for intervention, minimize the initial brain injury and help repair the damage in later post-stroke phases, Dr. Janic said.

The early signs of stroke are often unrecognized, and many patients cannot take advantage of clot-busting treatments within the required few hours after stroke onset, said Anthony Atala, M.D., editor of STEM CELLS Translational Medicine and director of the Wake Forest Institute for Regenerative Medicine. In this animal study, a combination of stem cells shows promise for healing stroke damage when administered 24 hours after the stroke.

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The full article, Intravenous administration of human umbilical cord blood derived AC133+ endothelial progenitor cells in rat stroke model reduces infarct volume magnetic resonance imaging (MRI) and histological findings, can be accessed at http://www.stemcellstm.com.

About STEM CELLS Translational Medicine: STEM CELLS TRANSLATIONAL MEDICINE (SCTM), published by AlphaMed Press, is a monthly peer-reviewed publication dedicated to significantly advancing the clinical utilization of stem cell molecular and cellular biology. By bridging stem cell research and clinical trials, SCTM will help move applications of these critical investigations closer to accepted best practices.

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Stem cell therapy shows promise in repairing brain damage

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Aug. 10, 2013 Results from a clinical trial of eteplirsen, a drug designed to treat Duchenne muscular dystrophy, suggest that the therapy allows participants to walk farther than people treated with placebo and dramatically increases production of a protein vital to muscle growth and health. The study, led by a team in The Research Institute at Nationwide Children's Hospital, is the first of its kind to show these results from an exon-skipping drug -- a class of therapeutics that allows cells to skip over missing parts of the gene and produce protein naturally.

"I've been doing this for more than 40 years and this is one of the most exciting developments we've seen," says Jerry Mendell, MD, lead author of the study and director of the Center for Gene Therapy at Nationwide Children's. "It offers great hope to patients with Duchenne muscular dystrophy and their families."

The research, which appears online Aug. 1 in the journal Annals of Neurology, is the first study from a double-blind controlled randomized trial of an exon-skipping agent to provide conclusive proof based on the standard six-minute walk test used to measure muscle function in patients with Duchenne muscular dystrophy (DMD), the most common form of muscular dystrophy in children.

About one in every 5,000 male births in the U.S. has the disorder, which usually leaves patients unable to walk on their own by age 12. Children with DMD have a mutation that cripples the body's ability to produce a protein called dystrophin, which helps absorb the shock or energy that's created when a muscle contracts. Without it, that released energy injures muscle fibers. Over time, the muscle degenerates, scar tissue builds up and fat slowly replaces the dead muscle.

The exact mutation varies from patient to patient but in 65 percent of cases, the dystrophin gene is missing large sections of DNA called exons, which carry the instructions for protein production. Accompanying this type of mutation is a spontaneously occurring reaction that enables muscle cells to skip over the deleted sections and produce smaller -- but functional -- versions of protein.

Eteplirsen, manufactured by Sarepta Therapeutics in Cambridge, Mass., mimics this naturally occurring phenomenon, allowing cells to skip over exon 51 in the dystrophin gene. About 13 percent of patients with the disorder have this mutation. Nationwide Children's began the phase II trial of eteplirsen in August 2011, enrolling 12 boys age 7 to 12 years.

Participants received the drug via weekly IVs, with one group getting a 30 mg/kg dose and another group receiving 50 mg/kg. A control group received a placebo. Participants completed a six-minute walk test at the outset and again at weeks 12, 24 and 48. Muscle biopsies were also taken when the study began and again at those intervals to measure for dystrophin-positive muscle fibers.

Although there was no dystrophin production at 12 weeks, participants showed a 23 percent increase in dystrophin-positive muscle fibers by the 24-week mark. The striking improvement and lack of side effects prompted researchers to switch participants in the placebo group to the drug. By week 48, participants had a 52 percent increase in dystrophin-positive muscle fibers and were able to walk 67.3 meters farther than the placebo group on the six-minute walk test.

Although the results are promising, Dr. Mendell is quick to note that the small study leaves many questions unanswered. For example, researchers would like to know how the drug affects dystrophin production in muscles throughout the limbs and whether some muscles may get a bigger boost than others.

"We know that if you have an area that is not expressing dystrophin, the membrane will be fragile and vulnerable to activity-related degeneration," says Dr. Mendell, who also is director of the Neuromuscular Disorders program at Nationwide Children's and a professor of pediatrics in The Ohio State University College of Medicine. "There may be factors that lead to preferential localization of the dystrophin production. That's one of many issues we'd like to investigate further."

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Combined therapy could repair and prevent damage in Duchenne muscular dystrophy, study suggests

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Toronto, ON (PRWEB) August 10, 2013

Bel Marra Health, who offers high-quality, specially formulated vitamins and nutritional supplements, reports on a recent study revealing that the mutation in the SLC26A4 gene causing hearing loss could be restored.

As Bel Marra Health reports in its article, (http://www.belmarrahealth.com/general-health-2/could-a-gene-restore-your-hearing/) hearing loss is a problem that affects roughly 13 percent of the United States this means 38.2 million people in the country suffer from partial or total loss of hearing. Whether it's noise-related hearing loss, age-related deafness, or even genetic hearing impairment, the loss of one of the most important senses we have can impact many aspects of one's life. Fortunately, the results of a new research study suggest that these effects may not have to be permanent after all, locating a specific gene that may hold the key to restoring hearing loss for good.

The journal PLoS Genetics has recently published an article detailing the success of a project at Kansas State University. The researchers at the university attempted to restore balance and hearing. Their findings show promise for great things in the future of auditory exploration.

The study examined hereditary or genetic hearing loss, specifically deafness caused by a mutation in the SLC26A4 gene. The mutation of this gene can cause pendrin (a protein that is found in the cells of your inner ear) expression to be reduced, which can lead to swelling in the inner ear. This swelling can not only lead to loss of balance, but also hearing loss. Thus, the goal of the study was fairly simple: fix the genetic mutation problem, and the ear should start working properly once again.

During the study, the first problem researchers encountered was that the SLC26A4 gene was produced in so many parts of the body, therefore it became impossible to eliminate it all. Their solution was to simply remove the gene from the inner ear and cochlea. The study - conducted on mice - resulted in the mice having their hearing restored for the duration of the test period, as there was no swelling of the inner ear that was responsible for their hereditary hearing loss. The correction of this simple gene mutation proved to be enough to restore the hearing in mice, which shows much potential as further studies need to be conducted for the future of treating deafness in humans.

In a previous study, published in the July 2012 edition of the journal, Neuron, another cause of hearing loss was tackled: damage to the hairs of the inner ear. These hairs are responsible for picking up all the little vibrations that are translated into sounds by the brain, but genetic defects in these hairs can lead to hearing impairment and hearing loss.

Dr. Lawrence Lustig and a team of doctors at the University of California in San Francisco, injected a protein named VGLUT3 directly into mice suffering from hereditary deafness. The result showed all of the mice in the study were able to hear once again. There was no damage to the ear, and the injections actually helped to correct structural defects in the cells making up the inner ear hairs.

So, what do both of these studies mean to the future of hearing aid technology? Some speculate that a brand new phone app could render hearing aids a thing of the past, while others believe that these studies could lead to serious strides of progress towards curing genetic deafness. While these studies were only done on mice, the success of the studies will lead to human testing - which may eventually lead to discoveries that will help mankind to cure hearing loss once and for all.

(SOURCE: Xiangming Li, et al. SLC26A4 Targeted to the Endolymphatic Sac Rescues Hearing and Balance in Slc26a4 Mutant Mice. PLoS Genetics, 2013.)

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Bel Marra Health Reports on Recent Research Revealing A Gene To Restore Hearing Loss

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Paul Root Wolpe: Kurzweil #39;s Singularity Prediction is Wrong (YouTube Geek Week!)
Bioethicist Paul Root Wolpe argues that the Singularity envisioned by Ray Kurzweil isn #39;t quite right. SUBSCRIBE to Big Think: http://goo.gl/cZlhxI Watch more...

By: Big Think

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Paul Root Wolpe: Kurzweil's Singularity Prediction is Wrong (YouTube Geek Week!) - Video

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3 Cool Materials That Mimic Shark Skin
Sharks are built to be the perfect killers, swimmers, and survivors. And we lowly humans are finally realizing the genius of their design. And their skin is ...

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3 Cool Materials That Mimic Shark Skin - Video

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If Initiative 522 passes, raw agricultural products that are genetically engineered, and processed foods with such ingredients, will have to be labeled beginning July 1, 2015.

Agricultural products would be labeled genetically engineered. Processed foods would carry a label on the front of packages saying partially produced with genetic engineering or may be partially produced with genetic engineering.

Although the measure refers to genetic engineering, such crops are more commonly called genetically modified organisms, or GMOs.

Here are some key details:

Food sold in restaurants is exempt, as are alcoholic beverages.

Certified organic food, which by law cant contain any deliberately added GE ingredients, is also exempt.

Meat from animals that are genetically engineered must be labeled, but not meat from animals that ate genetically engineered feed.

Food produced with processing aids or enzymes is exempt if those are its only genetically engineered ingredients. Until July 1, 2019, there is an exemption for processed food in which genetically engineered ingredients are 0.9 percent or less of the total weight.

Genetically engineered seeds sold at retail also would be labeled.

Retailers, farmers and anyone else in the food business could be protected from liability if they have statements from either suppliers or an independent testing organization saying ingredients are not genetically engineered.

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What I-522 would require

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Public School Supporter Hollywood Hypocrite Matt Damon sends kids to private school
Matt Damon, whose mom is a public school teacher, has long been a vocal advocate of public schools. And yet, as he moves to LA, he #39;s sending his four daughte...

By: LSUDVM

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Public School Supporter

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Horrible Drunk People Play Borderlands 2! 1x30: Drunks Argue Genetics
Rob from http://flailthroughs.blogspot.com plays through Borderlands 2 along with Isstvan82 and AngeliqueDaemon! This session I was slightly lit and they wer...

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Horrible Drunk People Play Borderlands 2! 1x30: Drunks Argue Genetics - Video

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A lesson in basic genetics
FIRST member and former biology teacher gives a unique lesson in basic genetic mutation.

By: firstskinfoundation

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A lesson in basic genetics - Video

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Empire Farm Days Polled Genetics Panel Part I

By: TheHolsteinWorld

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Empire Farm Days Polled Genetics Panel Part I - Video

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The molecular genetics of down syndrome
The molecular genetics of down syndrome by Kevin M. Windisch MD, FAAP and Sparks Pediatric and Adolescent Medicine.

By: Kevin Windisch

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The molecular genetics of down syndrome - Video

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Lawsuits Californias Ambry Genetics shoots back with dueling lawsuit over gene testing.

A California company sued by Myriad Genetics over its competing test for genes related to breast cancer is striking back with allegations that the patents the Utah-based company is relying on are invalid and that it is illegally monopolizing the market for such products.

The allegations by Ambry Genetics of Aliso Viejo, Calif., were filed in U.S. District Court for Utah in response to a lawsuit against it by Myriad shortly after Ambry announced it had begun offering genetics tests that compete with Myriads.

Ambry and another company, Gene by Gene of Houston, began offering tests that compete with Myriads after the U.S. Supreme Court in June struck down parts of five patents Myriad holds related to genes called BRCA1 and BRCA2. Mutations of those genes indicate a high probability a patient will suffer from hereditary breast or ovarian cancer and detection of them can guide efforts to prevent the cancers or treatment of them.

Myriad also sued Gene by Gene last month, asserting that the Utah company still holds valid patents that Gene by Gene is infringing upon.

Now Ambry is countersuing, saying some of Myriads patents are invalid under the Supreme Court decision in the Myriad case and another gene-related case.

Ambry contends Myriad is merely relying on standard lab practices to copy and sequence genetic materials and those methods are not eligible to be patented.

"As a result, Myriad now seeks to wrongfully enforce a de facto monopoly on the unpatentable genes to the detriment of women in the United States," Ambrys attorneys write in the companys counterclaim.

They also claim Myriad filed the lawsuit in part because Ambry was depositing patient test results in a public data base that could help researchers develop competing tests.

Myriad did not return an email Friday afternoon seeking comment on the allegations.

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Company claims Utah’s Myriad Genetics maintains illegal monopoly

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Stem Cell Therapy Treatment for Stroke by Dr Alok Sharma, Mumbai, India.
Improvement seen in just 5 day after Stem Cell Therapy Treatment for Stroke by Dr Alok Sharma, Mumbai, India. After Stem Cell Therapy 1. Voluntary control of...

By: Neurogen Brain and Spine Institute

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Stem Cell Therapy Treatment for Stroke by Dr Alok Sharma, Mumbai, India. - Video

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By: InterAksyon.com August 9, 2013 10:02 AM

InterAksyon.com The online news portal of TV5

MANILA, Philippines - The controversy over unregulated stem cell procedures in the country, including the role of unlicensed foreign doctors, has reached Congress, from where several alleged victims of malpractice came. The vice chairman of the House blue-ribbon panel is set to deliver a privileged speech Monday ahead of hearings on the current state of things in the stem cell therapy practice in the country, where experts warned earlier the "fad-like" atmosphere poses serious threat to public health and safety.

Rep. Doy Leachon of Oriental Mindoro is expected to train his sights on, among others: the unethical practice of stem cell therapy without Food and Drug Administration (FDA) approval and on unapproved indications; the charging of exorbitant fees for still-experimental procedures; the criminal liabilities of doctors who prey on the miseries of desperate sick patients; a review of the potential conflict of interest, unethical conduct of self-promotion and violation of FDA rules in pushing stem cell therapy and charging of fees involving the Philippine Medical Association (PMA) and Philippine Society for Stem Cell Medicine (PSSCM).

Leachon wants the academe, ethics experts and the Philippine College of Physicians to shed light on the multidimensional controversy.

The House inquiry may also focus on the deaths of two congressmen who allegedly died after undergoing stem cell therapy; and the case of Dangerous Drugs Board chairman Antonio Villar, who developed adverse reactions.

Expected to be summoned to the House hearings, besides representatives of the PMA and PSSCM are officials of the FDA, Department of Health, PRC, Securities and Exchange Commission, Bureau of Immigration, Bureau of Internal Revenue and other stakeholders.

Earlier this week, the Professional Regulations Commission (PRC) served notice it would require special permits from foreign doctors who conduct stem cell procedures in the country. It warned that those failing to do so, as well as their local partners, face criminals charges for medical malpractice.

For his part, Leachon--saying a class suit is possible against doctors in cases where the stem cell therapy was found to have caused deaths and adverse reactions--encouraged patients victimized by "unscrupulous con artists and who developed side effects" to report to his office.

Leachon, a lawyer, was a TOYM awardee in public service in 2011.

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House panel trains sights on unregulated stem-cell therapy in PH

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By Rick Nauert PhD Senior News Editor Reviewed by John M. Grohol, Psy.D. on August 8, 2013

Researchers for years have been on a tantalizing quest to developa drug to slow age-related memory loss.

Biochemical researchers from the Linus Pauling Institute at Oregon State University say memory loss with aging is a biological process associated with brain subunits and neurotransmitters areas and substances that could be replaced or revived with drug, nutritional or genetic therapy.

For example, if you forget where you put your car keys and you cant seem to remember things as well as you used to, the problem may well be with the GluN2B subunits in NMDA receptors.

These brain regions help you remember things, but youve been losing them almost since the day you were born, and its only going to get worse. An old adult may have only half as many of them as a younger person.

Research on these biochemicals is making it clear that cognitive decline with age is a natural part of life, and scientists are tracking the problem down to highly specific components of the brain.

Separate from some more serious problems like dementia and Alzheimers disease, virtually everyone loses memory-making and cognitive abilities as they age. The process is well under way by the age of 40 and picks up speed after that.

But of considerable interest: It may not have to be that way.

These are biological processes, and once we fully understand what is going on, we may be able to slow or prevent it, said neuroscientistKathy Magnusson, Ph.D.

There may be ways to influence it with diet, health habits, continued mental activity or even drugs.

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Mouse Study Uses Gene Therapy to Bolster Memory

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Joy Lee

The China Post/Asia News Network

Friday, Aug 09, 2013

TAIPEI - Linkou Chang Gung Memorial Hospital yesterday published research showing that aristolochic acid is a carcinogen that can cause gene mutation.

Science Translational Medicine, an interdisciplinary medical journal established in October 2009 by the American Association for the Advancement of Science, published the research as the cover story of its most recent issue.

Linkou Chang Gung Memorial Hospital worked with National Cancer Centre Singapore to discover all the damage aristolochic acid can have on human bodies, including causing cancer and gene mutation.

According to the research, aristolochic acid, a natural product of aristolochia plants found in herbal remedies and health supplements, is the strongest source of carcinogens thus far discovered.

The Department of Health (DOH), now named the Ministry of Health and Welfare, banned use of any herbal medicines that contain aristolochic acid in 2003 due to potential kidney damage. However, the research also found that aristolochic acid can not only cause lasting damage to kidneys but also to livers.

Linkou Chang Gung Memorial Hospital's research team said that people should not try any herbal remedies that contain aristolochic acid and if they start to develop symptoms like feeling pain or bumps around waist area, they should go to a doctor immediately for professional consultation.

In April 2001, the US Food and Drug Administration issued a consumer health alert against consuming botanical products that were sold as traditional medicines or as ingredients in dietary supplements that contained aristolochic acid.

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Herbal medicine ingredient linked to cancer

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Latest Diet & Weight Management News

WEDNESDAY, Aug. 7 (HealthDay News) -- Researchers have identified a gene associated with overweight and obesity in both psychiatric patients and people in the general population.

It was known that the CRTC1 gene is involved in obesity and energy balance (calories taken in by eating and drinking versus calories burned through physical activity) in animals, but its role in human weight was unknown.

In this study, researchers examined whether different versions of the CRTC1 gene were associated with weight in psychiatric patients and people in the general population.

"Our results suggest that CRTC1 plays an important role in the high prevalence of overweight and obesity observed in psychiatric patients. Besides, CRTC1 could play a role in the genetics of obesity in the general population, thereby increasing our understanding of the multiple mechanisms influencing obesity," wrote Eva Choong, of Lausanne University Hospital in Switzerland, and colleagues.

The study was published online Aug. 7 in the journal JAMA Psychiatry.

The researchers also found a strong association between CRTC1 variants and fat levels in women younger than 45. This finding shows the need for further research on the link between fat levels and reproduction, the researchers said in a journal news release.

-- Robert Preidt

Copyright 2013 HealthDay. All rights reserved.

SOURCE: JAMA Psychiatry, news release, Aug. 7, 2013

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Gene Tied to Obesity in Humans

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Joy Lee

The China Post

Publication Date : 09-08-2013

Linkou Chang Gung Memorial Hospital yesterday published research showing that aristolochic acid is a carcinogen that can cause gene mutation.

Science Translational Medicine, an interdisciplinary medical journal established in October 2009 by the American Association for the Advancement of Science, published the research as the cover story of its most recent issue.

Linkou Chang Gung Memorial Hospital worked with National Cancer Centre Singapore to discover all the damage aristolochic acid can have on human bodies, including causing cancer and gene mutation.

According to the research, aristolochic acid, a natural product of aristolochia plants found in herbal remedies and health supplements, is the strongest source of carcinogens thus far discovered.

The Department of Health (DOH), now named the Ministry of Health and Welfare, banned use of any herbal medicines that contain aristolochic acid in 2003 due to potential kidney damage. However, the research also found that aristolochic acid can not only cause lasting damage to kidneys but also to livers.

Linkou Chang Gung Memorial Hospital's research team said that people should not try any herbal remedies that contain aristolochic acid and if they start to develop symptoms like feeling pain or bumps around waist area, they should go to a doctor immediately for professional consultation.

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Taiwan research links herbal medicine ingredient to cancer

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ARLINGTON, Va.--(BUSINESS WIRE)--

One of the most common techniques used by anti-biotech campaigners on the Web is the circulation of Top 10 type lists, which purport to unmask the biotech industry and top scientists and regulators for churning out lies about genetically modified (GM) foods that will lead to the destruction of the global food supply.

The Genetic Literacy Project (GLP) put the search terms myths about GM foods in Google and came up with more than 1.6 million entries and thousands of articles with titles like 10 reasons why we dont need GM foods. It is a compilation of the most egregious (and easily debunked) claims by advocacy groups.

To inject reason and logic into the debate, GLP is launching a new project. The Genetic Literacy Project will release occasional infographics to represent what the science says about crop biotechnology.

The first infographic 10 Reasons We Need Biotech Foods and Cropsis included in the GLP Weekly Newsletter, and is also available on the GLP website. It comes complete with source links to international foundations, research organizations, major science journals and leading newspapers.

Agricultural and human biotechnology are reshaping farming, food and medicine. The GLP explores the intersection of DNA research, media and policy to disentangle science from ideology. The Genetic Literacy Project is a non-profit organization funded by grants from non-partisan foundations. GLP also accepts donations from individuals. GLP does not accept funding from any industry or corporation. The GLP is affiliated with the non-profit Statistical Assessment Service (STATS) based at George Mason University in Virginia, which supplies administrative support for the GLP, and with the Center for Health & Risk Communication at GMU.

Photos/Multimedia Gallery Available: http://www.businesswire.com/multimedia/home/20130808006230/en/

MULTIMEDIA AVAILABLE:http://www.businesswire.com/cgi-bin/mmg.cgi?eid=50688169&lang=en

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Genetic Literacy Project Infographic: 10 Reasons We Need Biotech Foods and Crops

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Clin Med 7 31 13 Genetics 1

By: Evilstockboy

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Clin Med 7 31 13 Genetics 1 - Video

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Clin Med 8 1 13 Genetics 2

By: Evilstockboy

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Clin Med 8 1 13 Genetics 2 - Video

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Empire Farm Days Polled Genetics Panel Part II

By: TheHolsteinWorld

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Empire Farm Days Polled Genetics Panel Part II - Video

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Empire Farm Days Polled Genetics Panel
DairyBusiness Communications in partnership with the NY Holstein Association is sponsoring a free Polled Genetics Panel at Empire Farm Days.

By: dairylineradio

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Empire Farm Days Polled Genetics Panel - Video

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#39;Spiritual Genetics - Part 2 #39; by Pastor Apollo C. Quiboloy on Powerline - SMNI
Powerline: August 6, 2013 What is Spirit and truth? The Spirit that we talk about here is the spirit of obedience to His Will that makes us connected to the...

By: Sonshine Media Network International

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'Spiritual Genetics - Part 2' by Pastor Apollo C. Quiboloy on Powerline - SMNI - Video

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