Genetics, Epigenetics, Biology and the Emotions. Chris Astill-Smith - Chapter 9 of 9

By: Clive Bingham

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Genetics and Plant Breeding in Interwar Britain: A Double Forgetting of History
This is a paper I presented at the 24th International Congress of History of Science, Technology and Medicine, held in Manchester. A huge thank you to all th...

By: Dominic Berry

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Genetics and Plant Breeding in Interwar Britain: A Double Forgetting of History - Video

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Don #39;t Fight Your Genetics
Video reveals the best diet to lose weight http://www.thephysiqueformula.com Want to build muscle? Hire jimmy http://www.jimmysmithtraining.com What suppleme...

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How genetics and environment work together to shape our destiny: Milena Georgieva at TEDxAUBG
A young scientist in Bulgaria with lots of prestigious awards for best scientific excellence practices I put my all energy in revealing the secrets of the wa...

By: TEDxTalks

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Add productivity and profitability with Balancer genetics
Scott Hamilton, a cow-calf producer in South Dakota, uses Balancer bulls to add productivity and profitability in his calves as well as his cow herd. For more information, visit http://www.gelbvieh.org.

By: AmericanGelbvieh

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Macular Degeneration And Acupuncture: Gene Therapy and Stem Cell for AMD Safe?
http://www.MacularDegenerationSupport.com or (908) 264-5484 Download the FULL webinar for free by clicking the link. Dr. Andy Rosenfarb conducted an hour lon...

By: Dr. Andy Rosenfarb

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Macular Degeneration And Acupuncture: Gene Therapy and Stem Cell for AMD Safe? - Video

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OMICS Group Gene Therapy 2012 Opening Ceremony

By: Srinu Babu Gedela

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OMICS Group Gene Therapy 2012 Opening Ceremony - Video

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Gene Therapy for the Eyes is Coming of Age
Dr. Joe talks more about gene therapy. http://online.liebertpub.com/doi/full/10.1089/hum.2013.050.

By: Joe Prendergast

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The Personalized Medicine project and the Trial Outline Builder tool
Prof. Yuzuru Tanaka, a professor of the Department of Computer Science in Hokkaido University talks about his role in the Personalized Medicine project helpi...

By: ecancer medicalscience

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The personalized medicine project and improving user interfaces for clinicians and patients
Dr. Dieter Wallach, the managing director of Ergosign discusses the collaboration between Ergosign and p-medicine in creating user interfaces for clinicians and patients. He also talks about...

By: ecancer medicalscience

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The Personalized Medicine project: How semantic interoperability will improve treating patients
David Perez-Rey discusses his involvement with semantic interoperability and data model issues in the Personalized Medicine project, the main differences tha...

By: ecancer medicalscience

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The Personalized Medicine project and the Clinical Decision Support tool
Dr. Anca Bucur of Royal Philips Electronics of the Netherlands discusses Philips involvement in the Personalized Medicine project in helping create the Clini...

By: ecancer medicalscience

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Everybody #39;s Doing It! Aging with a Spinal Cord Injury
People with SCI are living longer after injury than ever before. Consequently, they can now expect to live long enough to develop the same kinds of age-relat...

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Training Day mit Querschnittslhmung - Spinal Cord Injury
via YouTube Capture.

By: Soufian21

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John Barker - Regenerative medicine and body cures
Regeneration to most of us conjures up a scene from a long forgotten science fiction movie, but John Barker, Director, Frankfurt Initiative for Regenerative ...

By: IFTV

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Mac Stem Cell Therapy 2012
Before and After Mac #39;s Stem Cell Therapy. Surgery done by Dr. Mark McCloskey, DVM, Columbus, OH.

By: Mary Hammond

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Cardiac Reconstruction: The Latest in Cell Therapy - kchrs2011
Cardiac Reconstruction: The Latest in Cell Therapy - kchrs2011.

By: Dhanunjaya Lakkireddy

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Aug. 2, 2013 Specific mutations (N676K) in the FLT3 receptor can contribute to the development of acute myeloid leukemia. The FLT3 receptor regulates cell growth, while activating gene mutations promote the uncontrolled proliferation of white blood cells. These findings were reported in the specialist journal Blood by a group of scientists from the Helmholtz Zentrum Mnchen and the Hospital of the Ludwig Maximilians University (LMU) in Munich as part of a clinical research collaboration with the German Cancer Consortium (DKTK). The results provide the basis for the development of new leukemia treatments using specific inhibitors, which block growth signals.

Gene mutations often trigger cancer. These changes in the DNA mostly affect the regulators of cellular metabolism or cell growth, which cause cells to degenerate and proliferate rapidly. Many such gene mutations that cause leukemia have been identified.

In about one third of patients with acute myeloid leukemia (AML) the malignant cells have a mutation in the growth-regulating FLT3 receptor. As the team of scientists headed by Dr. Philipp Greif and Professor Karsten Spiekermann have now discovered, blood cancer cells from a substantial number of patients in a subgroup of AML (so-called core-binding factor leukemias) also carry mutations in this receptor. Mutations affecting amino-acid position N676 have not been previously detected and may allow a new classification of this form of leukemia, which is characterized by extremely high white blood cell counts. "The FLT3 receptor mutations we have found in these leukemia patients provide a new basis for treating the disease," says Dr. Philipp Greif. "We already have FLT3 receptor inhibitors at hand, which we can now use to treat the affected patients."

The study was conducted by the clinical cooperative group "Pathogenesis of acute myeloid leukemia," a collaboration between the Helmholtz Zentrum Mnchen (HMGU) and the Department of Internal Medicine 3 at the Hospital of the Ludwig Maximilians University (LMU). The project leader and last author, Dr. Philipp Greif, heads a team of young scientists funded by the German Cancer Consortium (DKTK) within the clinical cooperative group. Professor Wolfgang Hiddemann, who heads the group, stresses the importance of this interdisciplinary collaboration: "Our results show in an exemplary way how innovative research methods, such as high-throughput DNA sequencing, allow discoveries, even in structures that have already been thoroughly examined. These insights into the molecular basis of the disease open up new treatment options for patients."

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The above story is based on materials provided by Helmholtz Zentrum Muenchen - German Research Centre for Environmental Health.

Note: Materials may be edited for content and length. For further information, please contact the source cited above.

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Discovery of novel gene mutations in leukemia patients opens up personalized therapy options

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Aug. 2, 2013 A study of gene expression led by scientists at the EMBL-European Bioinformatics Institute (EMBL-EBI) and the University of Cambridge has revealed the first steps of evolution in gene regulation in mice. Published in the journal Cell, the research has implications for the study of differences in gene regulation between people.

"We found an impressive amount of variation between these apparently very similar mice in terms of transcription-factor binding, which is an important indicator of gene-regulation activity," says Paul Flicek of EMBL-EBI. "Often you'll see a specific combination of these transcription factors acting in concert -- and it was fascinating for us to see just how important these combinations are. They're much more likely to be conserved over the course of evolution than whatever DNA sequence they might be binding to."

The team studied gene expression in five very closely related mouse species in order to pinpoint changes at the very earliest stages of evolution. To do this, they compared the way that three transcription factors (TFs) bind to genes to control if they're turned on or off in liver cells in the different mouse species.

"By looking at mice that are very closely related to each other, we were able to capture a snapshot of what regulatory evolution is happening," explains Duncan Odom of the University of Cambridge. "That's important because it's much harder to see how something has evolved when you don't have a clear picture of the starting point."

Say you wanted to know how an orange tree evolved, but you could only compare it to an elm or oak. You'd have greater insight into how an orange tree evolved if you could compare it to much more closely related plants like grapefruit and lemons, which could give insight into how each came from an ancestral citrus plant. In this study, instead of comparing leaf and fruit shapes, the team looked at gene regulation in mice that had only recently diverged from one another. They demonstrated that TFs work in clusters that are conserved in order to ensure genetic and evolutionary stability.

The researchers contrasted their findings with gene-regulation data from another model organism, Drosophila, to see where the similarities lay. They found that there were a lot more differences between closely related mouse strains than there are between distantly related fruit-fly strains.

"Mammals have lots of DNA kicking around that doesn't code for proteins, while fruit flies have relatively little. So a mouse's regulatory wiring will just have a lot more wiggle room than a fruit fly's," says Paul. "That gives us a clearer picture of what we can expect to learn about mammalian genetic regulation from fruit flies."

The study could help scientists understand how gene regulation differs from one person to the next, explaining why genes that cause disease in some people don't have that effect in others.

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Study of gene expression has revealed first steps of evolution in gene regulation in mice

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Charli (8, left) and sister Meg (4), with Daisy at home in Kaitangata this week. Photo by Helena de Reus.

Charli (8) and Meg (4) Owen, of Kaitangata, have undiagnosed cerebellar ataxia, which affects their co-ordination and balance and makes them tire easily.

The sisters' geneticist, Cure Kids chairman Prof Stephen Robertson, has been working on some revolutionary research in conjunction with Prof Russell Snell, of the Centre for Brain Research in Auckland.

The research aimed to deliver methods for diagnosing such disorders in the future.

''The nub of this family's issue is a neurological disorder, which affects the girls' gait and balance. Their ataxia is not associated with any intellectual disability; it's all about balance,'' he said this week.

"A lot of people have ataxia, but in this instance we've exhausted all the tests in conventional medicine to diagnose what form they have and we're now looking in the research arena for an answer for them,'' he said.

''It's clearly genetic, but the precise cause is proving hard to pinpoint.

''What has caused it in the family and what is the prognosis? That's the big question.

"We might find something that's brand new knowledge here, but in the end I hope it provides new and useful information for the family,'' Prof Robertson said.

The human genetic constitution has about 21,000 genes accounting for about 1% of a human's DNA.

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Gene tech research may aid diagnosis

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Brainstorm #39;s Applied Human Genetic Engineering Speech
A persuasive speech advocating that we should create Neosapiens. I had requested a three day conference at a stadium with teleprompters. Denied.

By: brainsturm6

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Key points in the genetically modified food debate

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GeneticS-TenZ - Black Ops II Game Clip
Game Clip.

By: Genetics Gaming

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Genetics, Epigenetics, Biology and the Emotions. Chris Astill-Smith - Chapter 8 of 9

By: Clive Bingham

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Aug. 1, 2013 If two women have the same genetic mutation that puts them at higher-than-average risk for a disease such as breast cancer, why does only one develop the disease?

In the current issue of PLoS Genetics, Michigan State University genetic scientists have begun to understand how the rest of the genome interacts with such mutations to cause the differences we see among individuals.

"It's been known for a while that genetic mutations can modify each other's effects," said Ian Dworkin, MSU associate professor of zoology and co-author of the paper. "And we also know that the subtle differences in an individual's genome -- what scientists call wild type genetic background -- also affects how mutations are manifested."

Dworkin and Sudarshan Chari, zoology doctoral student and the paper's lead author, wanted to know how common it was for wild type genetic background to alter the way genetic mutations interact with each other. This is the first time that it's been examined in a systematic manner, Dworkin added.

Using the fruit fly genome, the researchers found that wild type genetic background affected the outcomes of interactions between genetic mutations about 75 percent of the time. This could have huge implications in how scientists construct genetic networks -- maps of how genes interact with each other.

"It may be that some crucial portions of genetic networks are missing," he said. "It also seems that network descriptions are more fluid than we thought."

Fruit flies have been called humans with wings, genetically speaking, due to their similarities. By focusing on wings and a genetic mutation that alters them, the researchers demonstrated the influence of wild type genetic background was actually quite common.

The broader implication for humans is that even for diseases with a simple genetic basis, variation in the genome may matter for both understanding and treatment, Dworkin said.

This new insight explains how, in an example like breast cancer, every woman's genetic background is likely influencing how the mutation is expressed, causing different disease outcomes. The research also may help explain why some people benefit from a specific treatment for a disease, while others get no benefits or become resistant to a drug after a short time.

It's likely that most diseases with a suspected genetic component, such as cancer, asthma or Parkinson's, involve reactions between more than one set of genes. For Dworkin and Chari, the next step is to tease apart the intricacies of what's happening.

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Genetics: More than merely a mutated gene

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