Public release date: 23-Jul-2013 [ | E-mail | Share ]

Contact: Tracie White traciew@stanford.edu 650-723-7628 Stanford University Medical Center

STANFORD, Calif. Students who had their genome tested as part of a groundbreaking medical school course on personalized medicine improved their knowledge of the class materials by an average of 31 percent compared with those who didn't undergo the testing, according to a study by researchers at the Stanford University School of Medicine.

While the sample size was small 23 students sent their saliva to a commercial genetics testing company; eight did not the results may encourage educators to consider this approach in the future, the authors said.

"These results indicate that learning principles of human genetics is more powerful, and learning is more sustained, when exploring your own data," said Keyan Salari, MD, PhD, a former Stanford student who initially proposed the course, called "Genomics and Personalized Medicine." Salari, who is the lead author of the study, is now a urology resident at the Massachusetts General Hospital in Boston. The study will be published July 23 in PLOS ONE.

The eight-week elective course was the first in the country to give students in advanced-degree programs the option of personal genotyping as part of the curriculum. It was designed to teach them how the explosion of knowledge about genetics over the past 10 years could affect the treatment of patients. Since the course was first offered in 2010, the use of genetic testing in clinical care has grown.

The course, which is still being taught, was designed as a way to train future doctors and scientists in the skills necessary to use this new tool. The study, which was based on a pre- and post-course survey taken voluntarily by the majority of the students in the class, also showed that personal testing and the use of personal genotype data in the classroom did not appear to cause significant anxiety.

"This was a novel teaching approach," said Kelly Ormond, co-author of the study and associate professor of genetics. "There is always a lot of interest in whether personalized learning can influence education. ... What our study shows is that it might have benefits for some self-selected students, and is worthy of cautious consideration."

Initially controversial, the course was only approved after a campus task force met regularly for a year to debate the pros and cons of students undergoing genetic testing as part of a class. A number of concerns were raised, including the possible anxiety of learning they could be more susceptible to certain diseases, such as diabetes or Parkinson's. A number of safeguards were subsequently included as part of the course plan, including complete anonymity as to which students chose to undergo testing.

Salari conceived of the idea for the course in 2009 as a PhD student in genetics. He was working as a teaching assistant in the first-year human genetics course for medical students. At the time, the course curriculum consisted primarily of traditional genetics and didn't reflect the genomics revolution of the past 10 years. Salari had also recently undergone his own genetic testing, and saw the educational benefits.

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Genetic testing improved student learning in personalized medicine class, Stanford study finds

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July 23, 2013 Students who had their genome tested as part of a groundbreaking medical school course on personalized medicine improved their knowledge of the class materials by an average of 31 percent compared with those who didn't undergo the testing, according to a study by researchers at the Stanford University School of Medicine.

While the sample size was small -- 23 students sent their saliva to a commercial genetics testing company; eight did not -- the results may encourage educators to consider this approach in the future, the authors said.

"These results indicate that learning principles of human genetics is more powerful, and learning is more sustained, when exploring your own data," said Keyan Salari, MD, PhD, a former Stanford student who initially proposed the course, called "Genomics and Personalized Medicine." Salari, who is the lead author of the study, is now a urology resident at the Massachusetts General Hospital in Boston. The study was published July 23 in PLOS ONE.

The eight-week elective course was the first in the country to give students in advanced-degree programs the option of personal genotyping as part of the curriculum. It was designed to teach them how the explosion of knowledge about genetics over the past 10 years could affect the treatment of patients. Since the course was first offered in 2010, the use of genetic testing in clinical care has grown.

The course, which is still being taught, was designed as a way to train future doctors and scientists in the skills necessary to use this new tool. The study, which was based on a pre- and post-course survey taken voluntarily by the majority of the students in the class, also showed that personal testing and the use of personal genotype data in the classroom did not appear to cause significant anxiety.

"This was a novel teaching approach," said Kelly Ormond, co-author of the study and associate professor of genetics. "There is always a lot of interest in whether personalized learning can influence education. ... What our study shows is that it might have benefits for some self-selected students, and is worthy of cautious consideration."

Initially controversial, the course was only approved after a campus task force met regularly for a year to debate the pros and cons of students undergoing genetic testing as part of a class. A number of concerns were raised, including the possible anxiety of learning they could be more susceptible to certain diseases, such as diabetes or Parkinson's. A number of safeguards were subsequently included as part of the course plan, including complete anonymity as to which students chose to undergo testing.

Salari conceived of the idea for the course in 2009 as a PhD student in genetics. He was working as a teaching assistant in the first-year human genetics course for medical students. At the time, the course curriculum consisted primarily of traditional genetics and didn't reflect the genomics revolution of the past 10 years. Salari had also recently undergone his own genetic testing, and saw the educational benefits.

"I was curious about what stories were hidden in my genome, what health risks, what responses to drugs that might be predicted," Salari said. "For instance, I learned I might have a higher risk for age-related macular degeneration. That led me to read and learn a lot more about the genetics of that disease than I probably would have otherwise."

He added: "I wanted to find a way to translate my passion for genomics to all these medical students."

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Genetic testing improved student learning in personalized medicine class

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RUTHERFORD, N.J.--(BUSINESS WIRE)--

Cancer Genetics, Inc. (CGIX) ("CGI" or the "Company"), an emerging leader in DNA-based cancer diagnostics, launched its proprietary cervical cancer test and is marketing the molecular product globally through its network of distribution partners. Cervical cancer is the second most common cancer in women worldwide, with 500,000 new cases annually and almost 80% of cases occurring in developing countries.

CGIs FISH-based HPV-Associated Cancer Test (FHACT) uses a unique combination of genetic markers to detect genetic abnormalities located at 3q, 5p, 20q and chromosome 7. A recent study concluded that these four biomarkers are associated with the severity of cervical lesions. The findings of the study, published in the July issue of Gynecologic Oncology, http://dx.doi.org/10.1016/j.ygyno.2013.06.005, support the use of FHACT as an aid in the screening of women with HPV-positive abnormal cervical lesions. By identifying lesions that will progress to a higher grade versus those that will regress, FHACT can allow for a better triage of patients before referral for colposcopy and consequently reduce the associated healthcare burden.

The test can be performed directly on Pap smear or liquid based-cytology and does not require any resampling. It is therefore an ideal fit in countries where women have reduced access to routine screening. We think that FHACT will be a new tool to help identify women with high risk of progressing to cervical cancer, says Dr. Q. Annie Hasan, Ph.D., F.N.A.Sc., Head of Department and Senior Consultant, Department of Genetics and Molecular Medicine, Kamineni Hospitals, Hyderabad, India. This is particularly important in India due to the rising incidence of cervical cancer caused by difficulty in implementation of cervical screening programs, which require repeated evaluation in large number of women. In partnership with its distributors and collaborators, CGI will conduct workshops in India and Mexico to accelerate adoption of FHACT amongst the clinical community.

In industrialized countries, it is estimated that about one million women undergo colposcopy procedures each year, while only 3,700 cancer cases are actually diagnosed. The Company expects FHACT to aid in lowering healthcare costs and reducing the number of unwarranted colposcopies by providing genomic information of the lesion not available until now. CGI plans to make FHACT available in the U.S. later this year and will be working closely with several laboratories and hospitals to implement an early adoption of the test.

The design and development of FHACT was supported in part by a Small Business Innovation Research (SBIR) grant. In addition to cervical cancer, FHACT is applicable to other HPV-associated cancers. CGI is currently conducting ongoing validations with key thought leaders for head and neck cancer and anal cancer. Results from these studies are expected to be available by year end.

About Cancer Genetics, Inc.

Cancer Genetics, Inc. (CGI) is an emerging leader in DNA-based cancer diagnostics and servicessome of the most prestigious medical institutions in the world. Our tests target cancers that are difficult to diagnose and predict treatment outcomes. These cancers include hematological, urogenital and HPV-associated cancers. We also offer a comprehensive range of non-proprietary oncology-focused tests and laboratory services that provide critical genomic information to healthcare professionals as well as biopharma and biotech. Our state-of-the-art reference lab is focused entirely on maintaining clinical excellence and is both CLIA certified and CAP accredited and has licensure from several states including New York State. CGI has established strong research collaborations with major cancer centers such as Memorial Sloan-Kettering, The Cleveland Clinic, Mayo Clinic and the National Cancer Institute. For further information, please seewww.cancergenetics.com.

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Cancer Genetics Launches New Genetic Test For Cervical Cancer Management

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(PRWEB) July 22, 2013

The Institute of Regenerative and Molecular Orthopaedics (IRMO), world-renowned stem cell therapy experts, applauds the use of stem cell therapy for treatment of spinal injuries. In recent times, stem cell therapy has been increasingly sought after to support treatments of various injuries, especially in the sports world. Its use in repairing spinal injuries comes as good news to the thousands of Americans currently living with spinal cord injuries who are seeking the latest in breakthrough medical solutions.

Stem cell therapy is of the most exciting and promising treatments in modern medicine. Inroads are made every day, as the many applications of stem cell treatments become better understood by medical professionals around the world. Experts, like Dr. Joseph Purita of the Institute of Regenerative and Molecular Orthopaedics, have been utilizing stem cell treatments for many years to treat sports injuries.

Recent scientific and technological advancements have made stem cell extraction relatively inexpensive and accessible. Today, medical professionals have unprecedented access to these remarkable cells and are increasingly applying them in new ways to better aid in the bodys repair process. This includes advances in platelet rich plasma therapy (PRP), a process that takes a concentration of a persons own plasma and injects it into areas in need of new growth and tissue repair.

The use of stem cell therapy in the treatment of spinal cord injuries presents probably the biggest challenge yet for proponents of the treatment. Researchers are increasingly using stem cells to hopefully better understand its capabilities. The hope for spinal cord injuries is that one day stem cells can be used to generate new passageways for nerve signals to connect to muscles. The more stem cells are used for treatment in spinal cord injuries, the closer the medical field will be to fulfilling this promise.

Headed by the world-renowned stem cell treatment pioneer, Dr. Purita, the Institute of Regenerative and Molecular Orthopaedics is continually advancing the world of stem cell therapy treatments. They are one of the few orthopedic practices in existence that utilizes stem cell therapy, and PRP therapy, with orthopedic surgery to maximize a patients recovery outcome. As more stem cell treatments are being used to treat spinal injuries, Dr. Purita and his group look forward to seeing what great strides are made in battling the crippling condition in the near future.

About Stem Cell Orthopedic: The Institute of Regenerative and Molecular Orthopaedics (IRMO) is a world-class orthopedic practice and stem cell facility staffed with seasoned board certified orthopedic surgeons. They differ from most orthopedic practices because they offer stem cells and platelet rich plasma (PRP) therapy in conjunction with surgery or as alternative to surgical procedures. They utilize state-of-the-art technology and the latest in stem cell research to best treat their patients. IRMO uses hematopoietic stem cells (HSC), which are found circulating in blood, fat, and bone marrow, to help repair the body. They are headed by Medical Director, Dr. Joseph Purita, a world-renowned pioneer in laser orthopedic surgery and graduate of the esteemed Georgetown University Medical School. For more information, visit http://www.stemcellorthopedic.com/ or follow them on Facebook, Twitter, or YouTube.

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Stem Cell Orthopedic Applauds Use of Stem Cell Therapy for Spinal Injuries

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LAST week, we discussed the potential of medical tourism in the country which will also provide opportunities for destinations like Baguio once tapped, and subject to competitive and international standards and government/ regulatory requirements.

So much has been written and reported about Stem Cell Therapy including its extraordinary promises that research holds for the treatment of a wide range of diseases and conditions.

This week, lets delve deeper.

What is Stem Cell Therapy?

Cell Therapy has been interchangeably called many names such as cellular therapy, fresh cell therapy, live cell therapy, glandular therapy, or xenograph or xenotransplant therapy.

The International Society for Stem Cell Research (ISSCR) describes stem cell therapy as a treatment that uses stem cells, or cells that come from stem cells, to replace or to repair a patients cells or tissues that are damaged. The stem cells might be put into the blood, or transplanted into the damaged tissue directly, or even recruited from the patients own tissues for self-repair.

Stem Cells have been differentiated based on where in the body or what stage in development they come from. ISCCR has enumerated them as follows (source:www.isscr.org):

1. Adult Stem Cells or Tissue-specific Stem Cells. Many adult tissues contain stem cells that can replace cells that die or restore tissue after injury. Skin, muscle, intestine and bone marrow, for example, each contain their own stem cells. In the bone marrow, billions of new blood cells are made every day from blood-forming stem cells. Adult stem cells are tissue-specific, meaning they are found in a given tissue in our bodies and generate the mature cell types within that particular tissue or organ. It is not clear whether all organs, such as the heart, contain stem cells. The term adult stem cells is often used very broadly and may include fetal and cord blood stem cells.

Another type of adult stem cell is the mesenchymal stem cell. These are found in a number of tissues, including bone marrow, and may be able to produce bone, cartilage and fat. It is also possible that these or similar cells may aid in the regeneration of tissues. Extensive animal studies are currently ongoing to determine if these cells may be used for treatment of diseases such as arthritis and non-healing bone fractures. It is also possible that these or similar cells modulate the immune system in response to injury.

2. Fetal Stem Cells. Fetal stem cells are taken from the fetus. The developing baby is referred to as a fetus from approximately 10 weeks of gestation. Most tissues in a fetus contain stem cells that drive the rapid growth and development of the organs. Like adult stem cells, fetal stem cells are generally tissue-specific, and generate the mature cell types within the particular tissue or organ in which they are found.

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Last year an international team led by Cancer Research UK scientists at our Cambridge Research Institute unveiled the results of a huge research project called METABRIC . They used advanced gene sequencing techniques to analyse the patterns of gene activity in breast tumours from thousands of women, revealing the molecular signature of each tumour. The results showed that the disease could be divided into ten distinct subtypes, each with its own characteristics and outlook.

That work was just the beginning of the story. Since then, the researchers, led by Professor Carlos Caldas, have been delving into these subtypes in ever greater depth, trying to figure out what makes them different and how we can tackle each one more effectively.

In a new paper, published in the leading scientific journal Nature , the team took another look at the thousand breast cancer samples from the METABRIC study. But rather than looking at genes that bear the instructions to make proteins in our cells, the researchers focused instead on a set of genes that encode tiny lengths of RNA - a relative of the larger DNA molecules that makes up our genome.

In recent years it has become clear that these short pieces of RNA known as microRNAs, or miRNAs for short - can help to control when and where protein-making genes are switched on or off, and theyre an increasingly hot topic in the world of cancer research .

And now it looks like they may be playing a role in controlling how the immune system responds to certain breast cancers.

Small but powerful

First discovered in the 1990s in tiny worms called nematodes, microRNAs act as molecular switches inside cells, turning genes off when theyre not needed as well as fine-tuning gene activity levels. Theyre made from chopping up much longer strings of RNA a type of molecular messenger in cells.

Many hundreds of different microRNAs have now been identified, and they can recognise and act on individual genes in various ways. And thanks to projects such as ENCODE , we also know theres a lot more in the genome still to be discovered.

Researchers already know that cancer cells contain different levels of microRNAs compared to healthy cells - generally, they tend to be lower - and some types of cancer seem to have a characteristic microRNA fingerprint. This suggests that they could be useful for helping to diagnose or potentially even treat the disease.

Professor Caldas and his team wanted to find out whether the ten distinct subtypes of breast cancer theyd identified in the METABRIC study also had a telltale microRNA signature, and whether this matched up with the particular characteristics of that type.

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Featured Article Academic Journal Main Category: Obesity / Weight Loss / Fitness Also Included In: Genetics Article Date: 22 Jul 2013 - 5:00 PDT

Current ratings for: Could severe obesity be in the genes?

Scientists have discovered a particular gene mutation that could be linked to a cause of severe obesity.

Researchers from Boston Children's Hospital carried out a number of genetic surveys in several groups of people suffering from obesity, as well as a series of genetic experiments in mice.

The research, published in the journal Science, analyzed a gene called Mrap2 in different groups of mice. This particular gene has a human counterpart, which according to the scientists appears to be involved in regulating metabolism and food consumption.

The researchers explained that the protein encoded by the Mrap2 gene sends a signal to a receptor in the brain called Mc4r. This receptor assists in increasing the metabolism and decreasing appetite in a "signaling chain" involved in energy regulation.

They explain that fat cells produce a hormone called leptin. This hormone triggers receptors in the brain to start the production of a second hormone called aMSH.

Mrap2 helps Mc4r detect the aMSH hormone, which essentially leads to a drop in appetite and weight. The scientists explain that any mutations in this signaling chain are likely to increase the risk of obesity.

The researchers analyzed two groups of mice. One group who had the Mrap2 gene removed from just the brain, and one group who had the gene removed from "whole-of-body."

Both groups of mice grew to around twice their normal size, but weight gain was greatest in those with the gene removed completely.

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Could severe obesity be in the genes?

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We previously reported that direct-to-consumer genetic tests can spur positive lifestyle changes, but we're back to warn you that a recent study done at Emory University in Atlanta has shown that the results of the at-home kits can vary widely. Not only that, but a Google search here at ThirdAge.com revealed that two of the companies in the study, deCODEme, and Navigenics, are no longer selling their products. However, customers who had already used the kits can still get their results, which is reason enough to pay attention to divergent findings of the Emory team! The link to deCODEme leads to a page that says: "Sales of Genetic Scans direct to consumer through deCODEme have been discontinued!" The link to Navigenics takes us to a page that says: "We are no longer accepting orders or samples for the Navigenics Health Compass service." The third company, 23andMe, is still in business.

A release from Emory quotes lead researcher Cecile Janssens as confirming the demise of deCODEme and Navigencis "Although two of the companies that we studied are no longer operating, genotyping and sequencing is becoming less expensive and testing such as this is increasingly popular," she said. "The methods used for predicting these types of results are of important concern."

Janssens and colleagues published their findings online in the journal Genetics in Medicine. Test results provided by the three companies at the time of the study indicated an individual's risks for a large number of diseases. The study was conducted by creating DNA datafor a hypothetical population of 100,000 individuals, which is "a less expensive and equally valid method for demonstrating the variations in predicted risk among the companies," according to the release. Predicted risks, which were calculated using the methods of the three companies detailed on their websites, were assessed and compared for six diseases:type 2 diabetes, prostate cancer, celiac disease, Crohn disease, age-related vision loss, and abnormal heart rhythm. The variations in predicted risks were explained by three factors: *The companies considered a different number of genetic variants in the risk calculations.Generally a larger difference in the number of variants implied more variation in predicted risks. *All three companies used an estimate for the average population disease risk as a starting point for their predictions. Differences in average risks affect predicted risks of all consumers to the same extent.For example, when the average odds is two times higher, all predicted odds are also two times higher.

*The companies applied different mathematical formulas. The formulas of two companies led to an overestimation of risks when predicted risks were higher and even predicted risks that were higher than 100 percent. "Our study provides insight into the methodology and performance of risk estimation for personal genome tests," Janssens explains. "Future efforts to design predictive models will benefit from understanding the strengths and limitations of these current models and formulas."

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