A new cancer drug for patients with the same faulty gene as actress Angelina Jolie has shown "impressive responses" in a clinical trial, researchers have said.

The potential drug, called BMN 673, targets DNA repair in cancer cells and is designed to attack tumours that have been left vulnerable by genetic mutations.

BRCA genes were brought into the public consciousness last month after Jolie, 37, revealed she underwent a double mastectomy when doctors told her that her faulty gene - BRCA1 - meant she had an 87% risk of developing breast cancer and a 50% risk of ovarian cancer.

Scientists studying BMN 673 found the drug was "well tolerated" by patients and showed "excellent anti-tumour activity", the Institute of Cancer Research (ICR) and the Royal Marsden NHS Foundation Trust said.

The results of the trial - which was funded by US firm BioMarin Pharmaceutical and involved the University of Newcastle and several American institutions - were presented at the American Society of Clinical Oncology (Asco) meeting in Chicago.

Some 70 patients with a range of cancers, including ovarian or peritoneal, and breast, were monitored, and patients with cancers linked to BRCA mutations saw the most substantial improvement.

The researchers used different measures of the drug's effect on tumour instability and breakdown.

One was a clinical score called Recist, which included a range of measures such as whether visible lesions, or cracks, appear in the walls of tumours after treatment.

Some 11 of 25 evaluable ovarian cancer patients with BRCA mutations had a Recist-positive response to treatment, as did seven of 18 breast cancer patients with BRCA mutations.Signs of some clinical benefit were seen in several more patients, the experts said.

BRCA mutations reduce cells' ability to repair their DNA, and when inherited substantially increase the risk of developing a range of cancers, including breast, ovarian and prostate.

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Jolie gene drug trial 'impressive'

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RESEARCH TRIANGLE PARK, N.C.--(BUSINESS WIRE)--

Precision BioSciences, Inc., a leader in the field of genome engineering, today announced that it has filed a patent infringement lawsuit against Lonza Group (LONN.VX) and a number of its affiliates in the U.S. District Court for the District of Delaware. The lawsuit seeks a ruling that Lonzas importation into the United States and the use, offer for sale, and sale in the United States of the GS XceedTM Gene Expression System and CHOK1SV knock-out cell line infringe U.S. Patent No. 8,377,674 (the 674 patent), which applies Precision BioSciences Directed Nuclease EditorTM genome editing technology. The lawsuit requests monetary damages as well as a permanent injunction preventing Lonza from importing the GS XceedTM Gene Expression System and CHOK1SV knock-out cell line into the United States and from using, selling or offering to sell those materials in the United States.

Precision prefers to focus its business development efforts in a positive and productive manner, said Matthew Kane, CEO of Precision BioSciences. However, willful infringement of Precisions proprietary gene editing technology cannot be tolerated. The GS XceedTM Gene Expression System competes directly with Precision's GS knockout system that we developed using our award-winning Directed Nuclease EditorTM technology. We cannot allow Lonza to import, market, and sell a product developed using our intellectual property to customers in the United States without a license to do so.

Today, Precision controls a rapidly growing patent estate consisting of eighteen issued genome engineering patents. Precisions European and Australian patents claim methods that are similar to those claimed in the 674 patent. Certain of the European and Australian patent claims describe methods for modifying DNA in cells, such as the CHOK1SV cell line, using an engineered meganuclease.

About Precision BioSciences

Precision BioSciences mission is to continually provide, improve, and enable the worlds most powerful genome engineering technology. Precisions proprietary Directed Nuclease EditorTM (DNE) technology enables the production of genome editing enzymes that can insert, remove, modify, and regulate essentially any gene in mammalian or plant cells.

Precision BioSciences vision is to be the conduit through which the worlds greatest genome engineering challenges are solved. Precision has successfully utilized its DNE technology to create innovative products in partnerships with many of the worlds largest biopharmaceutical and agbiotech firms. Internally, Precision is developing DNE-based products for biologics manufacturing and human therapeutics. For additional information, please visit http://www.precisionbiosciences.com.

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Precision BioSciences Files Patent Infringement Lawsuit against Lonza Related to GS XceedTM Gene Expression System

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Public release date: 5-Jun-2013 [ | E-mail | Share ]

Contact: Press Office comunicacion@cnio.es Centro Nacional de Investigaciones Oncologicas (CNIO)

Researchers are still fascinated by the idea of the possibility of reprogramming the cells of any tissue, turning them into cells with the capacity to differentiate into cells of a completely different type pluripotent cellsand they are still striving to understand how it happens.

A group from the Spanish National Cancer Research Centre (CNIO), headed by researcher Ralph P. Schneider, from the Telomeres and Telomerase Group led by Maria A. Blasco, publishes this week an article in Nature Communications on the discovery of a new gene called TRF1 that is essential for nuclear reprogramming.

It is also known that TRF1 is indispensable for protecting telomeres, the ends of chromosomes. Existing evidence suggests that the length of telomeres and pluripotencythe capacity of a cell to differentiate into multiple cell typesare related. Pluripotent cells, for example, have very long telomeresa previous finding at CNIObut until now no protective protein for the telomeres had been found that was essential for pluripotency.

To investigate the connection between telomeres and pluripotency, researchers generated a 'reporter' mouse: they linked together the TRF1 gene and the gene coding for a green fluorescent protein and created a lineage of mice carrying this new genetic baggage. In these animals, the green fluorescent protein acts as a label to show expression of TRF1.

They discovered that TRF1 is an excellent marker for stem cells, both in adult stem cellsthose that are found in tissues and the different organs of the bodyand embryonic stem cells. It is also the case with 'induced pluripotent' stem cells (iPS cells), which are pluripotent cells that come from artificially reprogrammed specialised cells.

In the case of tissues, the authors write: "TRF1 distinguishes adult stem cells and is indispensable for their functioning". The discovery is useful for both identifying and eventually isolating the stem cell population in tissues, something that is important for the development of regenerative medicine. The cells in which TRF1 is expressed are also the most pluripotent.

In iPS cells, the same thing happens. The authors explain that: "The expression of TRF1 is an indicator of pluripotency. Those iPS cells that express the highest levels of TRF1 are also the most pluripotent. Furthermore, we demonstrate that TRF1 is necessary for the induction and maintenance of pluripotency, inhibiting the triggering of DNA damage responses and apoptosis ('cell suicide')".

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CNIO researchers identify a new gene that is essential for nuclear reprogramming

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Beijing, June 5 (IANS) Scientific experts and representatives from the World Anti-Doping Agency (WADA) and the International Olympic Committee (IOC) Wednesday met here to review the progress in combatting gene and cell doping.

Two of the experts, one in anti-doping area and another in gene therapy, believed that gene doping may not exist right now but the threat looms, reports Xinhua.

"Gene therapy is still in a very early stage, which makes me believe that there should not be athletes gene doping. But WADA is right to prepare a test as gene therapy is developing so fast that this sort of doping is a potential threat," said Beijing anti-doping lab head Xu Youxuan.

More than 70 experts, both home and abroad, attended the June 5-6 Gene and Cell Doping Symposium to discuss recent findings and solutions to combat the threat of athletes manipulating their genes to enhance their sports performance.

The symposium was organised by WADA in conjunction with China Anti-Doping Agency and Beijing Olympic City Development Association.

A difference from previous three meetings in New York in 2002, Stockholm in 2005 and St. Petersburg in 2008 is that discussion on cell doping became one of the meeting's agenda.

Beijing You'an Hospital chief Li Ning considered cell doping a more realistic threat than gene doping.

"The science for cell doping is less complicated than gene doping," said Li, taking blood transfusion as an example.

"After blood cells are tampered outside an athlete's body, the blood can have increased red blood cells and be transferred back to the body which is liking using EPO for an athlete," he said.

"As for gene doping, I believe it does not exist now but will appear in a near future," he added. Li heads a research project on the cutting-edge gene therapy to cure cancer. His research group has discovered the ADV-TK virus that can stop cancer cells from reproducing.

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Javascript is currently disabled in your web browser. For full site functionality, it is necessary to enable Javascript. In order to enable it, please see these instructions. 57 minutes ago by Lisa M. Krieger

The world's last passenger pigeons perished a century ago. But a Santa Cruz, Calif.-based research project could send them flocking into the skies again, using genetic engineering to restore the once-abundant species and chart a revival for other long-gone creatures.

The promise and peril of "resurrection biology" - which could bring back other long-gone species such as the woolly mammoth and Tasmanian tiger but runs the risk of undermining conservation efforts - was the topic for experts who gathered Friday at Stanford University's Center for Law and the Biosciences.

"The grand goal is to bring the passenger pigeon back to life," said researcher Ben Novak of Revive and Restore, supported by entrepreneur Stewart Brand's Long Now Foundation of San Francisco and conducted at the University of California at Santa Cruz. "We're at the baby step of stage one."

After studying old and damaged gene fragments of 70 dead passenger pigeons in the lab of UCSC professor Beth Shapiro, the team will assemble - in computers - the genetic code of the bird once hunted to extinction. They hope to complete that within a year.

Within two years, they plan to synthesize the actual DNA code, using commercially available nucleotides. This material will be inserted into the embryo of the passenger pigeon's closest living relative, a band-tailed pigeon.

Then there will be new challenges, Shapiro said.

"We need to turn it into a creature. We have to raise a captive breeding herd. Then there is the tricky part of going from a captive breeding bird to a live, thriving population in the wild," she said.

Passenger pigeons once numbered in the billions, blackening the skies and inspiring naturalists like John James Audubon, John Muir and Aldo Leopold. They had vanished by the first World War, victims of hunting and habitat loss.

But resurrected flocks reintroduced into a modern environment could be an invasive species, noted Andrew Torrance of the University of Kansas Law School. They also would be genetically modified organisms, subject to federal regulation.

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June 4, 2013 Using a novel genetic 'editing' technique, Duke University biomedical engineers have been able to repair a defect responsible for one of the most common inherited disorders, Duchenne muscular dystrophy, in cell samples from Duchenne patients.

Instead of the common gene therapy approach of adding new genetic material to "override" the faulty gene, the Duke scientists have developed a way to change the existing mutated gene responsible for the disorder into a normally functioning gene. The Duke researchers believe their approach could be safer and more stable than current methods of gene therapy.

The researchers are now conducting further tests of this new approach in animal models of the disease.

Duchenne muscular dystrophy is a genetic disease affecting one in 3,600 newborn males. The genetic mutation is found on the X chromosome, of which males have only one copy. (Females, with two X chromosomes, presumably have at least one good copy of the gene.)

Patients with Duchenne muscular dystrophy cannot produce the protein known as dystrophin, which is essential in maintaining the structural integrity of muscle fibers. Over time, patients with the disorder suffer gradual muscle deterioration, which leads to paralysis and eventual death, usually by age 25.

"Conventional genetic approaches to treating the disease involve adding normal genes to compensate for the mutated genes," said Charles Gersbach, assistant professor of biomedical engineering at Duke's Pratt School of Engineering and Department of Orthopaedic Surgery and member of Duke's Institute for Genome Sciences and Policy. "However, this can cause other unforeseen problems, or the beneficial effect does not always last very long.

"Our approach actually repairs the faulty gene, which is a lot simpler," said David Ousterout, the Duke biomedical engineering graduate student in the Gersbach lab who led the work. "It finds the faulty gene, and fixes it so it can start producing a functional protein again."

The results of the Duke study were published online in Molecular Therapy, the journal of the American Society for Gene and Cell Therapy. The project was supported by the Hartwell Foundation, the March of Dimes Foundation and the National Institutes of Health.

The Duke experiments, which were carried out in cell samples from Duchenne muscular dystrophy patients, were made possible by using a new technology for building synthetic proteins known as transcription activator-like effector nucleases (TALENs), which are artificial enzymes that can be engineered to bind to and modify almost any gene sequence.

These TALENs bind to the defective gene, and can correct the mutation to create a normally functioning gene.

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Genetic editing shows promise in Duchenne muscular dystrophy

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MADISON, Wis., June 5, 2013 /PRNewswire/ --Cellular Dynamics International (CDI) today announced that it has expanded its MyCell Products line, offering access to a number of human disease models and licensing key genetic engineering patents from Life Technologies and Sigma-Aldrich. CDI's MyCell Products include custom cell products manufactured using induced pluripotent stem cell (iPSC) technology to make stem cells or differentiated cells from any individual, including those with diseases of interest to pharmaceutical and academic researchers.

CDI's MyCell Products now offer access to a number of disease models, including cardiomyopathies and arrhythmias, vision disorders, neurological disorders, and muscular dystrophies. In addition, the company is actively working on expanding its disease model offering, currently working on additional disease models for neurodegenerative disorders and drug-induced liver injury (DILI).

Within the MyCell Products line, CDI maintains the iPSC line of each of the disease models, enabling customers to request manufacture of differentiated cells, such as cardiomyocytes, neurons, hepatocytes, and endothelial cells, for their discovery research.

In addition, CDI has licensed Life Technologies' GeneArt Precision TALs (TALENs) and Sigma's CompoZr ZFN technologies, which act like genomic scissors to cut DNA in a precise location. These nuclease technologies facilitate efficient genomic editing by creating double-stranded breaks in DNA at user-specified locations, stimulating the cell's natural repair process and enabling targeted gene insertions, deletions, or modifications. CDI will use the TALENs and ZFN technologies to perform genetic engineering specified by the customer, for example to introduce or correct a specific mutation, thus creating human disease models and isogenic controls.

"This expansion of the MyCell Products line is the next step in our growing disease-in-a-dish portfolio and allows our customers more ready access to diseases of interest from our growing catalog of iPSCs," said Chris Parker, CDI chief commercial officer. "Through the MyCell Products line, researchers can now access human disease models either through creation of iPSC-derived cells directly from a patient, or through inducing a disease state via use of these TALEN or ZFN technologies."

Bob Palay, CDI chief executive officer, said, "CDI's commercial goal has been to provide access to human cells that reproduce human biology, and we see both of these developments as steps toward achieving that goal. We're pleased to license these nuclease technologies from Life Technologies and Sigma-Aldrich, and the combination of these nuclease technologies with CDI's iPSC-derived cells creates a new, powerful tool to better understand and target human disease."

About Cellular Dynamics International, Inc.Cellular Dynamics International, Inc. (CDI) is a leading developer of stem cell technologies for in vitro use in drug discovery, toxicity testing and chemical safety, in vivo and cell-based therapeutic research and stem cell banking. CDI harnesses its unique manufacturing technology to produce differentiated tissue cells in industrial quality, quantity and purity from any individual's stem cell line created from a standard blood draw. CDI was founded in 2004 by Dr. James Thomson, a pioneer in human pluripotent stem cell research at the University of Wisconsin-Madison. CDI's facilities are located in Madison, Wisconsin. CDI's headquarters are located in Madison, Wisconsin, with a second facility in Novato, California. See http://www.cellulardynamics.com.

Follow us on Twitter @CellDynamics or http://www.twitter.com/celldynamics

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Cellular Dynamics International Expands MyCell Products Line with Disease Models, Genetic Engineering Patents

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Q: When is a Jew, not a Jew?
A: When he is Jewish, according to the latest Genetic DNA research carried out by Dr. Eran Elhaik #39; #39;a Jew" and associates at the McKusick-Nathans Institute of Genetic Medicine, Johns Hopkins...

By: TheWatchman144K

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Q: When is a Jew, not a Jew? - Video

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Public release date: 4-Jun-2013 [ | E-mail | Share ]

Contact: Vicki Cohn vcohn@liebertpub.com 914-740-2100 ext. 2156 Mary Ann Liebert, Inc./Genetic Engineering News

New Rochelle, NY, June 4, 2013The composition of breast milk varies from mother to mother, and genetic factors may affect the levels of protective components in breast milk that could influence a newborn's outcomes. The potential to perform genomic studies on breast milk samples is explored in a Review article in Breastfeeding Medicine, the Official Journal of the Academy of Breastfeeding Medicine, published by Mary Ann Liebert, Inc., publishers. The article is available free on the Breastfeeding Medicine website at http://www.liebertpub.com/bfm.

Kelley Baumgartel and Yvette Conley, University of Pittsburgh, PA, reviewed the scientific literature to determine whether breast milk is an appropriate source for genetic materialDNA and RNAto perform gene expression and epigenetic studies.

In the article "The Utility of Breast Milk for Genetic or Genomic Studies: A Systematic Review," the authors describe the potential value of the genetic information obtained from breast milk, which can be collected easily and noninvasively. It could lead to a better understanding of the variability in breast milk and to strategies for optimizing the neonatal diet through fortification of donor breast milk, supplementation of the mother's diet, or maternal lifestyle changes that would affect breast milk composition.

"The great majority of mothers produces milk that matches the needs of her infant amazingly well," says Associate Editor David S. Newburg, PhD, Professor, Department of Biology, Boston College, Chestnut Hill, MA. "But for those few infants with exceptional needs, such as premature infants, or for mothers with uncommon mutations whose milk lacks the full complement of beneficial components, genetic and genomic analysis would both identify the mismatch and provide the information to produce a personalized complementary fortifier or supplement."

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About the Journal

Breastfeeding Medicine, the Official Journal of the Academy of Breastfeeding Medicine (http://www.bfmed.org), is an authoritative, peer-reviewed journal published bimonthly in print and online. In 2014 the Journal will be publishing 10 issues per year. The Journal publishes original scientific papers, reviews, and case studies on a broad spectrum of topics in lactation medicine. It presents evidence-based research advances and explores the immediate and long-term outcomes of breastfeeding, including the epidemiologic, physiologic, and psychological benefits of breastfeeding. Tables of content and a sample issue may be viewed on the Breastfeeding Medicine website at http://www.liebertpub.com/bfm.

About the Publisher

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Can genetic analysis of breast milk help identify ways to improve a newborn's diet?

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Newswise BIRMINGHAM, Ala. A newfound genetic marker promises to better predict warfarin dose in African-Americans, according to a study published online today in The Lancet. If confirmed in further studies, the finding may help to avert more of the bleeds and blood clots that come when a patients starting dose misses the drugs narrow safety window.

First approved for use in 1954, the blood thinner warfarin effectively prevents clots but must be dosed carefully. A too-high starting dose can cause internal bleeding, while an insufficient dose may fail to protect against clots. In a hint at the promise of pharmacogenomics, inexpensive, 59-year-old warfarin may become more valuable each time a newly identified genetic marker makes more accurate algorithms used to predict dose for each patient.

As it stands, most physicians start patients on a standard five-milligram dose, closely monitor their clotting speed and adjust their dose based on it. The effort to reach a safe dose is complicated by the 20-fold variability in dose requirements observed in African Americans. The best available dosing models miss their mark often enough that warfarin causes a third of U.S. hospital visits related to drug side effects in patients aged 65 and older, with nearly two thirds of them due to bleeds.

Seeking to fix the problem, three previous genome-wide association studies (GWAS) sought to identify genetic factors that could improve warfarin dose prediction, but none of them included patients of African ancestry. That makes the current study, a seventeen-institution effort led by the University of Florida (UF), the first GWAS of its kind. The University of Alabama at Birmingham (UAB) was the largest enrolling center in the study, with local demographics and a tradition of tackling disparities best positioning it to recruit African-American patients.

Our goal is to help more patients arrive at their optimal dose more quickly, said Nita Limdi, Pharm.D., Ph.D., associate professor in the Department of Neurology within the UAB School of Medicine and co-first author of the study. As the field continues to identify genetic variations that affect dose, knowing which patients dont have certain variations will be as valuable as knowing which do.

Genome-wide association studies look at differences at many points in the genetic code to see if, across a population, one or more variations are found more often in those with a given trait, be it high risk for a disease or lower needed drug dose. The current study found that a single genetic variation is associated with a 20 percent warfarin dose reduction in people of African ancestry, an effect not present in patients of European or Asian ancestry. When incorporated into dosing algorithms, the new variant enabled the prediction of dose with 21 percent greater accuracy than the standard formula.

Clinic by clinic, doctors are starting to check genetic codes as a first step in determining each patients disease risk, likelihood of benefiting from a given drug or best dose, said Julie Johnson, director of the Center for Pharmacogenomics at the University of Florida and corresponding author for The Lancet publication. As this revolution unfolds, we need to ensure that all share in the benefits.

Where to start?

Clotting prevents small injuries from causing extended bleeds, but it can also be triggered by diseases like atrial fibrillation and cancer, as well as by surgery, aging and inactivity. Once formed, clots can float through the circulatory system to clog blood vessels elsewhere, causing heart attacks, strokes or pulmonary emboli. For these reasons, 33 million Americans got a prescription for warfarin in 2012 for the treatment and prevention of clots.

One reason warfarin is still the most widely prescribed anticoagulant, instead of newer, more easily tolerated drugs like dabigatran, rivaroxaban and apixaban, is its low cost. As a mainstay in the treatment of the underinsured in the United States, and for patients in developing countries, especially in Africa, making warfarin safer remains a priority.

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Genetic Marker Enables Better Prediction of Warfarin Dose in Patients of African Ancestry

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Genetics Introduction Video Ryan

By: Ryan Hart

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Genetics Introduction Video Ryan - Video

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MENLO PARK, Calif.--(BUSINESS WIRE)--

Personalis, Inc. today announced that it will be exhibiting at the European Society of Human Genetics Conference in Paris, France beginning Sunday, June 9, 2013. Personalis will launch its Genome Services for Research and Clinical samples, focusing on accuracy in sequencing, analysis, and interpretation of human genomes to the European market.

Personalis Genome Services include our Accuracy and Content Enhanced (ACE) Exome technology. Using additional custom targeted capture, we aim to finish genes in the medical exome and add medically interpretable content outside the exons. This has been shown to benefit work in medical genetics, pediatrics, cardiology, neurology, psychiatry, pharmacogenomics, and other areas of medicine.

Clinical quality genome interpretation also requires accurate and comprehensive databases of genetic variation. Personalis has the largest and most comprehensive manually-curated database in the world linking genetic variation with disease. We have also signed an exclusive license for commercialization of PharmGKB, the premier database linking genetic variation with drug metabolism and adverse events. Personalis also annotates genomes with information from over 30 databases. When combined with Personalis ACE (Accuracy and Content Enhanced) Technology for exome sequencing and powerful variant calling algorithms, researchers and clinicians are able to rapidly obtain the most comprehensive sequence analysis available. Personalis CEO, John West, stated We are pleased to extend this offering to the European community and are committed to expanding our global footprint to enable researchers and clinicians worldwide to take advantage of our products.

About Personalis

Personalis provides researchers and clinicians accurate DNA sequencing and interpretation of human genomes. Our ACE (Accuracy and Content Enhanced) Technology can supplement a standard exome or genome, substantially increasing its medically-relevant coverage and accuracy. Personalis builds on that with innovativealgorithms and proprietary databases for alignment, variant calling, annotation, and analysis. With this combination, we provide genomic data and interpretation of the highest accuracy.

Personalis has an exceptional team of scientific, medical and industry experts. Our R&D team brings directly relevant commercial experience from seven different DNA sequencing companies and scientific & medical expertise from the top universities in the world. This group has been deeply involved in many of the advances of recent years, and has a long track record of peer reviewed publications. We see enormous potential in human genome sequencings next big step: accurate interpretation.

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Personalis Announces Participation in the European Society of Human Genetics Conference

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LOS ANGELES, June 4, 2013 (GLOBE NEWSWIRE) -- Response Genetics, Inc. (RGDX), a company focused on the development and sale of molecular diagnostic tests that help determine a patient's response to cancer therapy, today announced that it has achieved its second milestone payment in conjunction with the non-exclusive license agreement originated in 2010 with GlaxoSmithKline ("GSK").

Under the terms of the agreement, GSK gained certain rights to Response Genetics' proprietary PCR analysis technology and diagnostic expertise to assess BRAF gene mutations in human tumor samples. Response Genetics earned its first milestone payment of $500,000 in July of 2012 for submission of the first Premarket Approval ("PMA") under the contract. On May 29, 2013, GSK announced the FDA's approval of the PMA, thereby triggering the second milestone payment of $500,000.

The BRAF gene is responsible for a protein involved in cell signaling, growth and differentiation. Specific mutations in the gene are found in a subset of patients with melanoma.Tafinlar(R) has been approved to treat melanoma that cannot be surgically removed or metastatic melanoma in adults with the V600E mutation of BRAF. Tafinlar(R) is not indicated for patients with wild-type BRAF melanoma.

"We are extremely pleased to have assisted GSK in achieving this very important milestone," said Thomas A. Bologna, Chairman and CEO of Response Genetics. "Response Genetics supports pharmaceutical companies by providing lab-developed tests that are critical for screening and stratifying patients during clinical development. The insights that emerge from our work, such as the association between the specific mutations of BRAF and response to Tafinlar(R), enable the practice of precision medicine, the selection of a cancer treatment based on the molecular characteristics of a patient's tumor."

About Response Genetics, Inc.

Response Genetics, Inc. (the "Company") is a CLIA-certified clinical laboratory focused on the development and sale of molecular diagnostic testing services for cancer. The Company's technologies enable extraction and analysis of genetic information derived from tumor cells stored as formalin-fixed and paraffin-embedded specimens. The Company's principal customers include oncologists and pathologists. In addition to diagnostic testing services, the Company generates revenue from the sale of its proprietary analytical pharmacogenomic testing services of clinical trial specimens to the pharmaceutical industry. The Company's headquarters is located in Los Angeles, California. For more information, please visit http://www.responsegenetics.com.

Forward-Looking Statement Notice

Except for the historical information contained herein, this press release and the statements of representatives of the Company related thereto contain or may contain, among other things, certain forward-looking statements, within the meaning of the Private Securities Litigation Reform Act of 1995.

Such forward-looking statements involve significant risks and uncertainties. Such statements may include, without limitation, statements with respect to the Company's plans, objectives, projections, expectations and intentions, such as the ability of the Company, to provide clinical testing services to the medical community, to continue to strengthen and expand its sales force, to continue to build its digital pathology initiative, to attract and retain qualified management, to continue to strengthen marketing capabilities, to expand the suite of ResponseDX(R) products, to continue to provide clinical trial support to pharmaceutical clients, to enter into new collaborations with pharmaceutical clients, to enter into areas of companion diagnostics, to continue to execute on its business strategy and operations, to continue to analyze cancer samples and the potential for using the results of this research to develop diagnostic tests for cancer, the usefulness of genetic information to tailor treatment to patients, and other statements identified by words such as "project," "may," "could," "would," "should," "believe," "expect," "anticipate," "estimate," "intend," "plan" or similar expressions.

These statements are based upon the current beliefs and expectations of the Company's management and are subject to significant risks and uncertainties, including those detailed in the Company's filings with the Securities Exchange Commission. Actual results, including, without limitation, actual sales results, if any, or the application of funds, may differ from those set forth in the forward-looking statements. These forward-looking statements involve certain risks and uncertainties that are subject to change based on various factors (many of which are beyond the Company's control). The Company undertakes no obligation to publicly update forward-looking statements, whether because of new information, future events or otherwise, except as required by law.

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Response Genetics Achieves Milestone Payments Totaling $1,000,000 for Services Provided to GlaxoSmithKline in the ...

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SEATTLE, WA--(Marketwired - Jun 5, 2013) - Atossa Genetics, Inc. (NASDAQ: ATOS), The Breast Health Company, announced today that Peter J. Carbonaro has joined the Company as Senior Vice President of Operations, a newly created position. Mr. Carbonaro's primarily focus and responsibilities include regulatory, quality, manufacturing, supply chain, IT, Facilities and Human Resources. He reports to Dr. Steven Quay, Chairman, CEO & President.

A veteran diagnostic/medical device/biotechnology industry decision maker, Mr. Carbonaro brings more than 30 years' experience in process development, supply chain and manufacturing. This includes expertise in product development, technology transfer, manufacturing and supply chain at a number of prominent companies including Gilead Sciences and Hoffmann LaRoche as well as several early stage companies.

"The Company is very fortunate to have Peter Carbonaro join us as at this pivotal time as we continue to ramp up sales and manufacturing of our ForeCYTE Breast Health Test," said Dr. Quay. "Peter's extensive industry experience and in-depth operations and manufacturing expertise will be invaluable in helping us make the ForeCYTE test available to millions of women across America."

"Atossa Genetics has the potential to change the way we think about breast cancer risk assessment and prevention and I am excited to join the Atossa team to help make the ForeCYTE test and other products and services developed by the Company become the standard of care," said Mr. Carbonaro. "I am honored to join the Atossa team to drive our success for the benefit of women in the fight against breast cancer."

Prior to joining Atossa Genetics, Mr. Carbonaro (54) served as Vice President, Operations, at Ondine Biomedical, Inc. from 2011 to 2013. From 2006 to 2011, Mr. Carbonaro served in increasingly responsible positions at Gilead Sciences, Inc., including Director of Manufacturing in Seattle, Washington; Director of Manufacturing in Ireland; Director of Global Operational Excellence, Pharmaceutical Manufacturing and Senior Director, Pharmaceutical Manufacturing. Earlier, Mr. Carbonaro served from 2001 to 2006 as Senior Director of Manufacturing for Corus Pharma, which was acquired by Gilead Sciences in 2006. From 1997 to 2001, Mr. Carbonaro was Vice President of Operations at Bartel, Inc., which was later acquired by Trinity Biotech.

Mr. Carbonaro began his career at Roche Diagnostic Systems, Inc., Belleville, New Jersey, where he served as Production Manager, Senior Group Leader and Associate Scientist. Mr. Carbonaro also served as Vice President of Operations and Director of Operations at Aprogenix, Inc., based in Houston, prior to joining Bartels.

Mr. Carbonaro holds an MBA in Organizational Behavior from Iona College and a BS degree in biology from Siena College.

On June 3, 2013, and as an inducement to cause Mr. Carbonaro to join the Company, he was awarded an option to purchase a total of 250,000 shares of common stock of the Company, par value $0.001 per share, 163,000 of which are outside the Company's 2010 Stock Option and Incentive Plan. The stock option has an exercise price equal to $4.58 per share, the fair market value on the grant date and vests over a four-year period from his commencement of service. This stock option was granted as an inducement material to Mr. Carbonaro's entering into employment with the Company and is being reported in accordance with NASDAQ Listing Rule 5635(c)(4).

About Atossa Genetics, Inc.

Atossa Genetics, Inc. (NASDAQ: ATOS), The Breast Health Company, based in Seattle, WA, is focused on preventing breast cancer through the commercialization of patented, FDA-designated Class II diagnostic medical devices and patented, laboratory developed tests (LDT) that can detect precursors to breast cancer up to eight years before mammography.

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Peter J. Carbonaro Joins Atossa Genetics as Senior Vice President of Operations

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Transhumanism Intro - (Sneak Peek)
http://www.jeremiahfilms.com The world is shifting, the "global consciousness" is moving towards a global system of technology, innovation, and communication...

By: JeremiahFilms

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Transhumanism Intro - (Sneak Peek) - Video

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Mickey #39;s Before After Stemlogix Stem Cell Therapy
Mickey, a 13 year old German Shepherd torn both of his ACLs and suffered from severe arthritis. Mickey has been treated with Stemlogix Stem Cell Therapy Platelet Max Platelet Rich Plasma...

By: Stemlogix, LLC

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Mickey's Before

Recommendation and review posted by Bethany Smith

Fibroblast Growth Factor FGF Stem Cell Therapy
Fibroblast Growth Factor Heals Heart Tissue by Feeding Stem Cells present.

By: David Dolores

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Fibroblast Growth Factor FGF Stem Cell Therapy - Video

Recommendation and review posted by Bethany Smith

Thumb Arthroscopy with Stem Cell Therapy
Hand surgeon Dr. Michael Fitzmaurice details the thumb arthroscopy procedure that he pioneered, involving an endoscopic approach and stem cell therapy (PRP) ...

By: Michael Fitzmaurice

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Thumb Arthroscopy with Stem Cell Therapy - Video

Recommendation and review posted by Bethany Smith

Sarasota, Florida (PRWEB) June 03, 2013

Guy DaSilva, MD, ABAARM, will begin conducting clinical trials for many degenerative diseases using adipose-derived stem cell therapy at the DaSilva Institute in Sarasota, Florida. The independent review board of the International Stem Cell Society will oversee the trials.

Following the IRB-approved protocols, Dr. DaSilva will treat patients suffering from chronic obstructive pulmonary disease (COPD), Type 2 Diabetes, osteoarthritis, critical limb ischemia and erectile dysfunction. Furthermore, Alzheimers disease, dementia and Parkinsons disease are pending approval, and approximately five new protocols are added each month.

While stem cell therapy is most often associated with the controversial use of embryonic stem cells, Dr. DaSilva will be exclusively using adult autologous stem cells, harvested from the patients own adipose (fat) tissue or bone marrow if fat is not available. Because patients are receiving their own cells, there is no risk of rejection, and success rates are far greater compared to the more contentious therapies.

Autologous stem cell therapy works by mimicking the bodys natural healing process, but at a more potent, concentrated level. Stem cells, which are unspecialized cells with the potential to develop into any cell, are stored throughout the body. When disease or injury strikes, the body sends these cells to the area in need, and they begin repairing and replacing damaged tissue. Stem cell function decreases with age, along with ones ability to heal. But with autologous stem cell therapy, the body is once again empowered to heal and reverse disease, and with much greater magnitude.

Dr. DaSilva trained under scientist Kristin Comella, Chief Science Officer of Bioheart, CEO of Stemlogix, Chief Scientific Officer of the Ageless Regenerative Institute, and was recently named one of the 50 most influential people on stem cells. Dr. DaSilva will implement Comellas patented extraction process to precisely isolate and remove stem cells from fat tissue, allowing for an exceptionally high yield and viability.

During the in-office procedure, a mini liposuction is performed on the patient to remove 60 milliliters of fat, which produces approximately 8 million stem cells. The stem cells are isolated and injected back into the patients body at the site of injury or disease. Only local anesthesia is needed, and the patient will go home pain-free.

Over the next month, the patients body will repair and regenerate itself naturally. Dr. DaSilva will continue to treat the patient, with therapies that range from high dose IV nutrition and heavy metal chelation to bio-identical hormones. This helps the body maintain a healthy environment to further promote cellular and mitochondrial healing.

According to Dr. DaSilva, autologous stem cell therapy is very promising. He says, This extraordinary therapy is going to change the face of medicine. For example, it has the capability to completely reverse Type 2 Diabetes with a single dose, allowing patients to avoid amputations, premature death, and a life of food monitoring and injections. The results are truly remarkable, and this is only the beginning.

About Guy DaSilva, MD, ABAARM

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Sarasota's Dr. Guy DaSilva Introduces Cutting-Edge Stem Cell Therapy For Degenerative Diseases

Recommendation and review posted by Bethany Smith

CHICAGO - Gene flaws that raise the risk of breast cancer are surprisingly common in black women with the disease, according to the first comprehensive testing in this racial group. The study found that one-fifth of these women have BRCA mutations, a problem usually associated with women of Eastern European Jewish descent but recently highlighted by the plight of Angelina Jolie.

The study may help explain why black women have higher rates of breast cancer at young ages - and a worse chance of survival.

Doctors say these patients should be offered genetic counseling and may want to consider more frequent screening and prevention options, which can range from hormone-blocking pills to breast removal, as Jolie chose to do.

"We were surprised at our results," said the study leader, Dr. Jane Churpek, a cancer specialist at the University of Chicago. Too few black women have been included in genetic studies in the past and most have not looked for mutations to the degree this one did, "so we just don't have a good sense" of how much risk there is, she said.

Churpek gave results of the study Monday at an American Society of Clinical Oncology conference in Chicago. The researchers include Mary-Claire King, the University of Washington scientist who discovered the first breast cancer predisposition gene, BRCA1.

Jolie revealed a few weeks ago that she carries a defective BRCA1 gene, giving her up to an 87% risk of developing breast cancer and up to a 54% risk for ovarian cancer. The actress's mother had breast cancer and died of ovarian cancer, and her maternal grandmother also had ovarian cancer. An aunt recently died of breast cancer.

Children of someone with a BRCA mutation have a 50% chance of inheriting it.

In the U.S., about 5% to 10% of breast cancers are thought to be due to bad BRCA genes. Among breast cancer patients, BRCA mutations are carried by 5% of whites and 12% of Eastern European (Ashkenazi) Jews. The rates in other groups are not as well known.

The study involved 249 black breast cancer patients from Chicago area hospitals. Many had breast cancer at a young age, and half had a family history of the disease.

They were given complete gene sequencing for all 18 known breast cancer risk genes rather than the usual tests that just look for a few specific mutations in BRCA genes.

Continue reading here:
Gene flaws common in black women with breast cancer

Recommendation and review posted by Bethany Smith

CHICAGO - Gene flaws that raise the risk of breast cancer are surprisingly common in black women with the disease, according to the first comprehensive testing in this racial group. The study found that one-fifth of these women have BRCA mutations, a problem usually associated with women of Eastern European Jewish descent but recently highlighted by the plight of Angelina Jolie.

The study may help explain why black women have higher rates of breast cancer at young ages and a worse chance of survival.

Doctors say these patients should be offered genetic counselling and may want to consider more frequent screening and prevention options, which can range from hormone-blocking pills to breast removal, as Jolie chose to do.

"We were surprised at our results," said the study leader, Dr. Jane Churpek, a cancer specialist at the University of Chicago. Too few black women have been included in genetic studies in the past and most have not looked for mutations to the degree this one did, "so we just don't have a good sense" of how much risk there is, she said.

Churpek gave results of the study Monday at an American Society of Clinical Oncology conference in Chicago. The researchers include Mary-Claire King, the University of Washington scientist who discovered the first breast cancer predisposition gene, BRCA1.

Jolie revealed a few weeks ago that she carries a defective BRCA1 gene, giving her up to an 87 per cent risk of developing breast cancer and up to a 54 per cent risk for ovarian cancer. The actress's mother had breast cancer and died of ovarian cancer, and her maternal grandmother also had ovarian cancer. An aunt recently died of breast cancer.

Children of someone with a BRCA mutation have a 50 per cent chance of inheriting it.

In the U.S., about 5 to 10 per cent of breast cancers are thought to be due to bad BRCA genes. Among breast cancer patients, BRCA mutations are carried by 5 per cent of whites and 12 per cent of Eastern European (Ashkenazi) Jews. The rates in other groups are not as well known.

The study involved 249 black breast cancer patients from Chicago area hospitals. Many had breast cancer at a young age, and half had a family history of the disease.

They were given complete gene sequencing for all 18 known breast cancer risk genes rather than the usual tests that just look for a few specific mutations in BRCA genes.

See original here:
Gene flaws are common in black women with breast cancer

Recommendation and review posted by Bethany Smith

CHICAGO (AP) New research suggests that bad genes may be responsible for more breast cancer cases in black women than has been previously known. About 1 in 5 African-American women with the disease have an inherited mutation that drastically raises their risk for breast and ovarian cancer, according to a study released Monday.

It may help explain why black women have higher rates of breast cancer at young ages, a more aggressive form of the disease, and worse survival. It doesn't mean that all black women are at risk or even that all blacks with cancer need genetic counseling or testing, said the study's leader, Dr. Jane Churpek of the University of Chicago.

Experts offer some advice about what to make of this information:

Q. What are the genes?

A. Mostly BRCA1 and BRCA2. Everyone has two copies of these genes, and a mutation in one can give a woman up to an 87 percent risk of developing breast cancer and up to a 54 percent risk for ovarian cancer. Sixteen other genes also can raise risk but are thought to be less common.

Q. Why might blacks have high risk?

A. African-Americans' genes are more diverse than those of many other racial and ethnic groups. Most of the mutations identified in this study were novel, or unique to each woman, Churpek said. It's possible that more detailed tests in whites and other groups might find a higher prevalence of mutations than previous studies have found in them, too.

Q. Should more black women be tested?

A. National guidelines do not specify any groups that should be tested except Eastern European (Ashkenazi) Jewish women with breast or ovarian cancer or a close relative who has had one of those diseases. Genetic counseling should be offered to black women who develop breast cancer before age 50, who have a close relative with the disease, or who have "triple-negative" breast cancer. Triple negative means tumors that are not fueled by estrogen, progesterone or the gene that the drug Herceptin targets.

Q. What can be done if a gene mutation is found?

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Advice for black women on breast cancer gene risk

Recommendation and review posted by Bethany Smith

Gene flaws that raise the risk of breast cancer are surprisingly common in black women with the disease, according to the first comprehensive testing in this racial group. The study found that one-fifth of these women have BRCA mutations, a problem usually associated with women of Eastern European Jewish descent but recently highlighted by the plight of Angelina Jolie.

The study may help explain why black women have higher rates of breast cancer at young ages -- and a worse chance of survival.

Doctors say these patients should be offered genetic counseling and may want to consider more-frequent screening and prevention options, which can range from hormone-blocking pills to breast removal, as Jolie chose to do.

"We were

In this May 31, 2013, photo, breast cancer survivor Alicia Cook holds a letter from the University of Chicago informing her that test results showed she had the BRCA genetic defect linked to breast cancer, outside her home in Chicago. New research shows genetic breast cancer is more common in black women than previously thought. (AP Photo/M. Spencer Green)

Churpek gave results of the study Monday at an American Society of Clinical Oncology conference in Chicago. The researchers include Mary-Claire King, the University of Washington scientist who discovered the first breast cancer predisposition gene, BRCA1.

Jolie revealed a few weeks ago that she carries a defective BRCA1 gene, giving her up to an 87 percent risk of developing breast cancer and up to a 54 percent

Children of someone with a BRCA mutation have a 50 percent chance of inheriting it.

In the U.S., about 5 to 10 percent of breast cancers are thought to be due to bad BRCA genes. Among breast cancer patients, BRCA mutations are carried by 5 percent of whites and 12 percent of Eastern European (Ashkenazi) Jews. The rates in other groups are not as well known.

The study involved 249 black breast cancer patients from Chicago area hospitals. Many had breast cancer at a young age, and half had a family history of the disease.

Go here to see the original:
In breast cancer war, gene flaws common in black women

Recommendation and review posted by Bethany Smith

CHICAGO, June 3, 2013 /PRNewswire/ -- Little is sacred for author Jaymie Simmon in her award-winning debut novel, The God Gene (2012, Twinbrook, Ltd., ISBN 978-1-937698-48-5, 408 pages, available at Amazon.com and Barnesandnoble.com) It reads at thriller pace, but takes a deep, darkly humorous dive into the American psyche at a point where information overload and political ambition collide. Simmon will introduce her book to the city in which it is set and sign copies at Chicago's iconic Printers Row Lit Fest on June 8 and 9 from 10 am until 6 pm.

(Photo: http://photos.prnewswire.com/prnh/20130603/AQ25020)

Multiple award-winnerThe God Gene won the 2013 National Indie Excellence Award for Literary Fiction. It was also a finalist in the 2013 Midwest Book Awards for Literary and Contemporary Fiction, and a finalist in the National Indie Excellence Award for Fiction. Simmon studied at the University of Chicago's Writer's Studio.

The storyThe story centers on Rosalind Evans, a beautiful, determined, 36-year-old cancer researcher at a Chicago university. She is completing work on a confidential pharma project when she discovers that the genetic code at the center of the second chromosome spells out The Ten Commandments. She fears her project has been hacked, but before she can investigate, a co-worker leaks the bizarre discovery to a popular blog. The story goes viral and the next morning the world wakes up to the news that there is a message from God in their DNA.

With the media fanning the flames, debate rages over the authenticity and meaning of the so-called God gene. Is it a hoax? A miracle? The end of times? Evans is the scapegoat for society's fear and uncertainty and becomes the victim of a conspiracy that reaches from the White House to the Vatican and from the ivory towers of academe to the boardrooms of big pharma. She must battle them all in order to regain her scientific integrity, her freedom, and ultimately, her life.

Author Jaymie Simmon says the idea for the book came from her insatiable appetite for political news. "I admit it: I'm a news junkie," Simmon says. "I've tried to quit, but American politics is like a Fellini movie; it's absurd, yet you can't take your eyes off it."

Praise for The God GeneJack Hatfield, Chairman of the Chicago Area Great Books Council, says, "I highly recommend The God Gene Fully developed characters. Interesting plot line. Very relevant to our times and its spiritual and moral ambiguity."

Phil Angelo of The Daily Journal says, "The humor here runs the gamut from laugh-out-loud to dark."

About the authorSimmon, a graduate of Northern Illinois University, chose to independently publish her book after researching both the indie and traditional publishing options. "Basically, I'm impatient. The God Gene took me seven years to write. I didn't want to wait another seven years for the traditional process to play out. When my work was finally published, I didn't want to be like Emily Dickenson. In other words, dead."

Simmon is an avid Lake Michigan sailor, cyclist, and community volunteer. She donates a portion of the proceeds from her book sales to charity. This year's recipient is BallouSkies, a charity that supports research for Duchenne Muscular Dystrophy.

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Satirical thriller The God Gene wins National Indie Excellence Award for Literary Fiction

Recommendation and review posted by Bethany Smith

M. Spencer Green / AP

Breast cancer survivor Alicia Cook holds photos of family members who have also been afflicted by breast cancer, outside her home in Chicago.

By Marilynn Marchione, The Associated Press

Gene flaws that raise the risk of breast cancer are surprisingly common in black women with the disease, according to the first comprehensive testing in this racial group. The study found that one-fifth of these women have BRCA mutations, a problem usually associated with women of Eastern European Jewish descent but recently highlighted by the plight of Angelina Jolie.

The study may help explain why black women have higher rates of breast cancer at young ages and a worse chance of survival.

Doctors say these patients should be offered genetic counseling and may want to consider more frequent screening and prevention options, which can range from hormone-blocking pills to breast removal, as Jolie chose to do.

"We were surprised at our results," said the study leader, Dr. Jane Churpek, a cancer specialist at the University of Chicago. Too few black women have been included in genetic studies in the past and most have not looked for mutations to the degree this one did, "so we just don't have a good sense" of how much risk there is, she said.

Churpek gave results of the study Monday at an American Society of Clinical Oncology conference in Chicago. The researchers include Mary-Claire King, the University of Washington scientist who discovered the first breast cancer predisposition gene, BRCA1.

Jolie revealed a few weeks ago that she carries a defective BRCA1 gene, giving her up to an 87 percent risk of developing breast cancer and up to a 54 percent risk for ovarian cancer. The actress's mother had breast cancer and died of ovarian cancer, and her maternal grandmother also had ovarian cancer. An aunt recently died of breast cancer.

Children of someone with a BRCA mutation have a 50 percent chance of inheriting it.

Read more:
Gene flaws linked to black women's greater breast cancer risk

Recommendation and review posted by Bethany Smith