Feb. 18, 2013 Genetic medicine experts from Manchester Biomedical Research Centre at Saint Mary's Hospital and The University of Manchester have identified a new gene responsible for causing an inherited form of tumour, known as spinal meningioma. Meningiomas are the commonest form of tumour affecting the brain and spine. Usually meningiomas can be removed by surgery and do not recur. Occasionally people can develop more than one meningioma or many members of the same family can be affected.

A team led by Dr Miriam Smith, Professor Gareth Evans and Dr Bill Newman worked with families with a history of meningiomas affecting the spinal cord. Using a powerful new genetic sequencing technique called next generation sequencing, they were able to check all the genes of three individuals with multiple spinal meningiomas. This lead to the identification that changes in a gene called SMARCE1 lead to spinal meningiomas in some families.

In December 2012 the government announced a focus on genetic sequencing with an aim of sequencing the genomes (a person's DNA) of 100,000 Britons with cancer and rare diseases in UK centres. The voluntary sequencing of patients will lead to better testing, better drugs and above all better care for patients. Manchester is already using this technology in their well established Genetics department at Saint Mary's and it is enabling doctors to ensure patients have access to the right drugs and personalised care quicker than ever before.

In the past year 10 genes have been discovered using the new next generation sequencing technology in Manchester including genes for developmental problems, deafness, short stature and bladder problems that lead to kidney failure.

"With our new DNA sequencing machines, we have been able to show that changes in the SMARCE1 gene are responsible for multiple spinal meningioma disease," said Dr Smith. "Before our work, doctors did not know that inherited spinal meningiomas have a completely different cause to other tumours affecting the brain and spine.

"The next step is to develop a screening programme to assess the risk of developing spinal tumours for individuals in affected families, and to investigate possible treatments to prevent the spinal tumours from growing."

Professor Richard Marias, Director of Cancer Research UK's Paterson Institute at The University of Manchester, said "This research highlights the complexity of tumour diagnosis. Such detailed molecular characterisation underpins current thoughts about how meningioma and cancer will be managed in the future and is at the heart of the personalised medicine approach." Just over two people in every 100,000 develop meningiomas in the head and spine, with twice as many women as men diagnosed with the condition.

The team's pioneering work was funded by The Children's Tumor Foundation, a US-based charity supporting neurofibromatosis research, and the Association for International Cancer Research, a global cancer research charity.

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Fitness Model Journey Ep2 - First World Problems
Add Me Facebook.com/EricBergePT Injury Check Up, Genetics, Diet....i keep getting sick is the biggest challenge... grr HELL ( Original Mix ) By CENOB1TE Discord ( At Dawn We Rage Remix ) Destroy ( Midnight Conspiracy Remix ) soundcloud.com creativecommons.org

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What Stems Cancer Cells? The discovery of a new cancer stem cell marker
Excited about stem cells? Want to learn how stem cells influence cancer growth? Learn how scientists are paving the way to a better understanding of the identity and behavior of cancer stem cells! For more exciting science videos, visit Youreka Science: http://www.yourekascience.com Original article: "Dclk1 distinguishes between tumor and normal stem cells in the intestine." Nakanishi et al. Nature Genetics, Jan 2013

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Fruit Fly Harlem Shake
Genetics nerds from Kyiv, Ukraine present you Drosophila melanogaster HARLEM SHAKE!

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Cataclysm: DDA - Character 2, Part 3: Lasers and Wolves
I continue on from the house in the middle of the woods, explore a lab, and head down the road. I really should have taken the robust genetics trait.

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Lot3 832
Homestead Genetics Bucking Bull Sale March 30th

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Homestead Genetics March 30th 2013 bull sale

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Boost: The Web Series - Official Teaser
The plot centers around Victor Blaine, a neurologist hired by a secret government organization called "Division" for his work and expertise in genetics, neuroscience and evolutionary psychology. Blaine had spent years developing a way to improve the cognitive functions of the brain after the boom of technology. Working on a serum (self proclaimed as "Boost") during the first animal test subject Blaine #39;s Boost project took an unexpected turn, discovering that the serum gave users extraordinary abilities. Division arranged for their first human test subject using the Boost prototype on "Elliot Fox" a former ex convict. The test proved to be successful however upon further observation over the course of 24 hours, Blaine had discovered that users of Boost developed a dependency on the drug and withdrawal from it caused violent aggression and paranoia in the subjects. Division had urged Blaine to fix the problem, when Blaine refused out of fear that the drug was too dangerous to carry forward. Division threatened to go after Blaine #39;s family. Blaine spent the next few years trying to perfect Boost all while trying to uncover who exactly his mysterious employers were. One night, Blaine accidentally stumbles upon some important data revealing that Division is actually a cult set on destroying the world and creating their own utopia. Blaine steals the data and destroys all the newly developed data of the Boost project and goes into hiding. Years later Elliot Fox is recruited by ...

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Bella, officially barefoot!
http://www.formspring.me instagram: kpontone One of the most incredible experiences I #39;ve ever had. I #39;m so thankful that my trainer allowed Bella to have the opportunity to be successfully barefoot! I still am leasing Bella so she did not have to let Bella have this opportunity, but I am so glad she did and once you see how Bella moved, you will be as stunned as I was! Truly amazing and certainly eye-opening! Blood in the white line due to diet issues and classified as subclinical or low level laminitis. Meaning inflammatory triggers in the diet cause the bleeding Will have a video of Bella #39;s movement up tomorrow. It is astonishing! Very cool to see "genetics" change! You can even see her genetics change just in the jog! She is moving comfortably and like a normal horse! Honestly never thought it was possible, but nature showed me how it #39;s done! I #39;m so excited to get down the lines now that she #39;s not going up and down out of pain anymore! Amazing what can happen when you give your horse the opportunity to be barefoot! Every horse deserves to be barefoot!

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The Genetics Underground V5
2 minute still frame pictures told in a sci-fiction narrative. Plot Synopsis: In the year 2030, the government has regulated the birth of humans. A fetus must pass a genome test to determine if it meets the qualifications of a good human specimen. As one woman tries to have a child, her off-springs keep failing the genome test. After several trials, she turns to more drastic measures in order to have a child of her own. Special Thanks to my group from DC 461 and our last minute actors.

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WAYS TO LOSE BELLY FAT WITH THE FAT LOSS FACTOR
WAYS TO LOSE BELLY FAT WITH THE FAT LOSS FACTOR eb2c96sinhmiau5cz8jfvckho6.hop.clickbank.net This is about one of the most exciting weight loss programs in America. The goal is to help you get a flatter belly while you still enjoy some of the foods you love. Before and after pictures and measurements show that some people lose belly fat the very first week they participate in the program. Many people are losing weight for the first time, and keeping the weight off.....This diet is the opposite of crash diets that put the body in starvation mode, causing a loss of muscle instead of fat. This diet helps people overcome genetics. Participants are taught how to lose weight while they still eat many of the so called "bad foods." There are some people using the Fat Loss Factor who are not successful, only because they do not follow the step by step directions. WAYS TO LOSE BELLY FAT WITH THE FAT LOSS FACTOR There are no supernatural berries and other scams in this diet. The inventors of this method believe that we do not get fat because we ate too many bad foods. They are experts in nutrition and wellness. Losses of up to 8 pounds in 9 days have been reported using this method, called the Fat Loss Factor. People are losing fat from their arms, legs, thighs and bellies...The liver is one of the keys to losing weight. The job of the liver is to break down toxic substances, and transfer fat throught the body. The first step of the Fat Loss Factor program is to purify the body ...

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Gene-therapy hope for East Lancashire woman with rare growth syndrome

12:00pm Monday 18th February 2013 in News By Jessica Cree, Ribble Valley reporter

Mandy Sellars hopes gene therapy will help shrink her legs

A WOMAN battling a rare condition in which she has 17-stone legs is hoping a new gene therapy will reverse the growth.

Mandy Sellars has a condition similar to Proteus Syndrome, the same condition that affected Elephant Man Joseph Merrick, which causes skin overgrowth and and abnormal bone development.

But the 38-year-old, who is originally from Bacup and now lives in Huncoat, is undergoing revolutionary gene therapy in Cambridge which she hopes will stop her legs from growing and even cause them to shrink back to a normal size.

She is to appear on a Channel 5 programme tonight which will document her progress and investigate the new treatment.

Mandy, who lives in Bolton Avenue, said: I have been doing quite well since the doctor found the gene therapy and I started taking some medication that they think will work.

I am a bit like a guinea pig and we want to see if the medication may help other people.

I never thought it would happen in my lifetime so it is fantastic news.

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Eddie G. Spinal Cord Injury Treadmill training at Pressing On
http://www.presssingontx.org - Pressing On client Eddie is a spinal cord injury/stroke/brachial plexus injury and traumatic brain injury. He has come a long way. This clip show him on the treadmill, pedaling a bike and pushing the elliptical at Pressing On. Like us on facebook at http://www.facebook.com/pressingontx

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Beckers Muscular Dystrophy After Stem Cell Therapy in Mumbai India
He is a 12 year old and a known case of BMD with history of gradual onset of progressive lower extremities muscle weakness since age of 7 years with complaints of difficulty in climbing stairs, getting up from floor. Weakness even progressed to upper extremities with difficulty in overhead activities and frequent falls. No family history. On examination, he has grade 3 #713; muscle power in proximal muscles of both upper extremities and lower extremities and 4 in distal muscles of both upper extremities and lower extremities. He has bilateral pseudohypertrophy of calf muscles and walks on toes. Neurologically, he is hypotonic and hyporeflexic. Functionally, he is independent in most of the ADL, needs assistance in lower body dressing. On FIM he score 109. After Stem Cell Treatment 1. Reports overall feeling of freshness and energetic. 2. Can manage to walk on heels. Earlier he would walk on toes. 3. Posture has improved. Earlier he would walk with lordosis. 4. Earlier he would need maximum support for stair climbing from both railing and one hand on knee, now only uses railing to climb stairs. 5. Stamina has improved and he has increased level of confidence. 6. Sit to stand and stand to sit transfers requires less efforts. 7. Can perform overhead activities with ease and maintains for a longer time. 8. Is more active than before. 9. Speech is clear and loud followed by deep inhalation and slow rate with prolongation technique. 10. Secondary behaviors also reduced like reduced ...

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Hypoxic Ischaemic Brain Injury Improvement After Stem Cell Therapy in Mumbai India
He is a case of Hypoxic Brain Injury since 4 years. Because of high grade fever of "chikungunya", he got cardiac arrest and went into coma for 1 year. During comatose stage, he had sacral and Greater Trochanter sores which are all recovered and he has developed myositis ossification at bilateral hip and right elbow. Hip myositis ossification was removed surgically. After comatose stage, he has recovered in speech and voluntary control. He has developed rigidity in trunk and lower extremities. In 2011,he had history of fall while walking and had right femur shaft fracture which was treated surgically with plate and screws in place. Neurologically, he is hypertonic and hyperreflexic. On examination, he has restricted range of motion of bilateral hip, knee and ankle and right elbow. Voluntary control of lower extremities is poor while voluntary control of upper extremities is fair. He has rigidity in bilateral lower extremities and spasticity of grade 2 in upper extremities muscles. Patient is dependent for all ADL. On FIM he scores 30. After Stem Cell Treatment 1. He feels ease in getting up from supine to sit. 2. He can sit straight for some time (5-10 minutes) ,earlier easily stoop in 5-10 seconds. 3. His sitting balance is improved than before, earlier had fear to tilt sideways. 4. His spasticity in lower limb has reduced. 5. His speech has become clear and with proper pauses. 6. He can do roll over on bed with ease and less assistance from caretaker than before. Stem ...

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Inclusive Body Myopathy Improvement After Stem Cell Therapy in Mumbai India
He is a case of Inclusive Body Myopathy, since last 16 years with the history of slowness in running speed and slipping of "chappals" while walking and following foot drop. Weakness is progressive in nature and now involved muscles of all 4 limbs and trunk. Since last 3 years he is bedridden. Muscle biopsy is showing Inclusive Body Myopathy and EMG-NCV reports are showing generalized primary muscle disease. His elder sister also suffering from the same problem. Neurologically, he is hypotonic and hyporeflexic. On examination: he has grade 1+ muscle power in all 4 limbs proximally and grade 0 foot muscles and grade 3 distal muscles of upper limbs. Proximal muscle weakness is more than distal. Functionally, he is dependent in all ADL and mobility. On FIM he scores 48. After Stem Cell Treatment 1. Stamina has increased. 2. He can do suspension exercises for more range of motion and with more repetition without fatigue. 3. Now he can initiate rolling. He takes less support for rolling and turning. Earlier he used to change his position 4-5 times because of discomfort, but now he needs to change his position only once at night. 4. He can initiate supine to sit. 5. He is able to perform side lying to sitting by himself upto 70%. 6. Attempted drinking water in modified manner with right hand, which he couldn #39;t do before. Stem Cell Therapy done at Dr Alok Shrama NeuroGen Brain and Spine Institute Surana Sethia Hospital Sion-Trombay Rd, Suman Ngr Opp Corporate Park, Chembur ...

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Autism Improvement After Stem Cell Therapy in Mumbai India
He is a known case of Autism with history of full term normal delivery, cried immediately after birth. He had near normal motor milestones with delayed speech. On examination, he has poor eye contact, poor concentration, poor attention span, poor language command. He is stubborn and aggressive (decreased with rehabilitation). He goes to normal school and had good memory but poor in social communication. On ISAA scale he scores 90. On WeeFIM, he scores 77. After Stem Cell Therapy Psychology assessment: 1) His attention and concentration has improved by 25%. Previously his remedial educator would take him in a group session as he would do an activity only under a competitive spirit whereas now he can even study alone. 2) Eye contact has improved. 3) His quantity and quality of vocabulary has improved about 25%. 4) Now, he is able to form sentences of 4-5 words whereas previously his speech was bisyllables. 5) Now he is able to formulate meaningful sentences and have a meaningful conversation. 6) Now he is learning new mathematical concepts and mother and teachers feel that study wise there are real good improvements. 7) Memory has improved ie now he is able to reproduce and recollect whatever has been taught to him in the school. 8) Speech therapist mentioned that he now does not require speech therapy whereas he now requires OT and remedial education. 9) Social interaction is better ie now he can initiate and engage himself and other people into an activity or conversation ...

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Spinal Cord Injury Improvement After Stem Cell Therapy in Mumbai India
She is a known case of Spinal Cord Injury since age of 1 year. After trauma she lost sensations of motor power below D6 level and on bowel bladder. MRI report showed 1) tiny focal traumatic contusion in cervical and upper dorsal spinal cord. 2) Grade 1 listhesis at C6-7 level. 3) Thin pre vertebral and anterior epidural hematoma. Initially she got good physiotherapy rehabilitation. She recovered in terms of bowel and bladder sensation, 50%. She has developed scoliosis (convexity towards right side) due to weakness of paravertebral muscles. Neurologically, she is hypertonic and hyperreflexic. She has ankle clonus. On examination: she has sensory loss below T6 level. She has grade 0 muscle power in bilateral lower extremities and near normal upper extremities strength. She is following time voiding for urination and she passes stool once in every 2-3 days. She has no pressure sores. On ASIA scale she scores "A". Functionally, she needs assistance in most ADL and wheelchair bound for mobility. On WeeFIM she scores 53. After Stem Cell Therapy 1. Exercises tolerance has increased. 2. Sitting posture is better. 3. She sits more erect now. Earlier, she used to stoop to one side. 4. Parents report that she responds to pain (being pinched on the side) now. Earlier would not be able to appreciate. Stem Cell Therapy done at Dr Alok Sharma NeuroGen Brain and Spine Institute Surana Sethia Hospital Sion-Trombay Rd, Suman Ngr Opp Corporate Park, Chembur, Mumbai -- 71. Tel : 022 ...

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Stem Cell Therapy at Integra Medical Center
New Project 82

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Broadcast journalist says the results are dramatic By Cheche V. Moral Philippine Daily Inquirer

DAVILA and her firstborn David at age 10

You can point a mother to the ends of the earth and it wont weaken her resolve to find that cure for her ailing child.

Broadcast journalist Karen Davilas firstborn, David, was 3 years old when he was diagnosed with Pervasive Developmental Disorder, Not Otherwise Specified (PDD/NOS) in the Autism Spectrum, a severe form of autism. The development pediatrician said there was no cure for Davids condition.

David didnt have the classic signs of autism, but clearly he wasnt developing like other children his age, says Davila. At the age of 3, he wasnt speaking spontaneously, although he could read. He had tantrums, couldnt express his needs, whether he was hungry or sad, and didnt reach out to other children his age.

Like most kids in the autism spectrum, the boy had attention difficulties. He was spaced out most of the time, and was rigid. It was so heartbreaking to see my eldest this way, she adds.

Davila refused to accept that there was no answer to her sons condition. I researched endlessly and devoted myself to making sure my son got the best possible treatment, she says. She quickly put her son on a casein- and gluten-free diet and biomedical treatment, under the care of Defeat Autism Now (DAN)-licensed doctors.

Davila explains that kids like David lack an enzyme in the body to digest casein, a protein found in cows milk, and gluten, a protein found in wheat, oats, barley and rye. When they take [casein and gluten], it feels like opium in the body, so kids feel high, theyre so hyper, get wild and are spaced out.

David, now 11, has also undergone anti-fungal treatments, and has been taking supplements and B12 injections to help his attention issues. He has also benefited from the help of occupational and speech therapists. Now in Grade 5, David is in his grade level in Multiple Intelligence School, in a smaller class ratio, according to his mother.

Early last year, Davila was offered an opportunity to try the fresh cell therapy being offered by a clinic in Germany called Villa Medica. The stem cells are harvested from lamb fetus and injected into the patient. By then, the journalist-mom had read up on the supposed benefits of stem cell on children with special needs.

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Published on 10 January 2013 Hits: 1,020 Written by Jovee Marie N. Dela Cruz

A HEALTH expert on Wednesday warned that stem cell therapy can also kill.

Dr. Leo Olarte, spokesman of the Philippine Society for Stem Cell Medicine, said that if the stem cell that a patient received is from a donor, it could lead to fatal complications.

He said that a stem cell transplant can pose risks of complications, some potentially fatal, depending on many factors including the type of blood disorder, the type of transplant and the age and health of the person.

Although some people experience few problems with a transplant, others may develop complications that may require treatment or hospitalization. Some complications could even be life-threatening, warned Olarte, also the vice chairman of the Philippine Medical Association.

He said that such complications could be in the form of graft-versus-host disease (allogeneic transplant only), stem cell (graft) failure, organ injury, infections, cataracts, infertility, new cancers and even death.

Olarte said that anyone undergoing a transplant using stem cells from a donor (allogeneic stem cell transplant) may be at risk of graft-versus-host disease.

This condition occurs when a donors transplanted stem cells attack your body. Graft-versus-host disease can be mild or severe. It can occur soon after your transplant or months to years later, he added.

The doctor said that incompatibility can also lead to diseases of the skin (rash, often like sunburn), gut (mouth sores, abdominal pain, diarrhea, nausea or vomiting), liver (jaundice or yellowing of the skin), lungs (blocked airways) or eyes (irritation and light sensitivity).

It can lead to chronic disability due to organ injury or infections and can be life-threatening. Your doctor must monitor closely for signs and symptoms of graft-versus-host disease, Olarte said.

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Advances in Brain-Machine Engineering
Todd Coleman presented his work at a symposium on Saturday 16 February, "Advances in Brain-Machine Interfaces: Applications and Implications." 2013 AAAS Annual Meeting in Boston (Credit: Todd Coleman, associate professor at the University of California, San Diego and UC San Diego Jacobs School of Engineering). - Machines That Communicate With the Body http://www.aaas.org An "electronic tattoo" the size of a postage stamp and the thickness of a human hair can be used to monitor laboring women and seizure-prone infants, because it provides a non-invasive way to track the electrical rhythms on the surface of the body, according to Todd Coleman of the University of California, San Diego. Another apparatus, developed by Miguel Nicolelis of Duke University Medical Center and colleagues, allows rats to "feel" infared light by stimulating the tactile center in their brains. Devices like these could have remarkable benefits, but they may also lead to ethical, legal and social quandaries that should be discussed as the technology progresses, researchers said at the AAAS Annual Meeting. Speakers in the session on brain-machine interfaces, organized by AAAS #39; Dialogue on Science, Ethics and Religion (DoSER) program, suggested that the most extreme examples mdash;of cyborgs or people endowed with superhuman abilities courtesy of machines mdash;are far from becoming reality. But neuroscience applications, in particular, are moving along much faster than other technologies like genetic engineering in the ...

By: Stefano Di Criscio

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Another day with cancer. GENETICS UPDATE
Today I had a genetics test orientation. This test specifically targets the BRCA1 and the BRCA2 genes that are most often found in breast cancers. If I do have a genetic mutation in either of these genes that is a good indicator that I may also develop a new breast cancer or ovarian cancer in the future. It also gives me and my family (kids) key information about how they need to be screened.

By: Freska Griarte

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