New Year's celebrations are likely to look a lot different this year than most, as many people heed warnings to steer clear of mass gatherings during the global COVID-19 pandemic. Wall Street also seems to have had some cold water thrown on what was otherwise an extremely strong year for the stock market, as major market benchmarks are down at midday on New Year's Eve. As of noon EST, the Dow Jones Industrial Average (DJINDICES:^DJI) was down 39 points to 30,370. The S&P 500 (SNPINDEX:^GSPC) lost 3 points to 3,729, and the Nasdaq Composite (NASDAQINDEX:^IXIC) eased lower by 36 points to 12,834.

Yet even with the markets losing ground, several of the year's best-performing individual stocks kept up their momentum. Shares of Fulgent Genetics (NASDAQ:FLGT) and Celsius Holdings (NASDAQ:CELH) have already soared in 2020, but investors were willing to put more money to work and send their share prices still higher on the final day of the year.

FLGT data by YCharts.

Shares of Fulgent Genetics were up more than 10% on Thursday at midday. The genetic testing and diagnostics company has gotten a lot of business from the pandemic, and Fulgent continues to pull in customers and demonstrate its value to shareholders.

Fulgent found itself in the right place at the right time in 2020, with its quick work in coming up with coronavirus tests leading to an at-home sample-collection kit that received approval from the U.S. Food and Drug Administration in June. The company's third-quarter revenue skyrocketed as a result, topping the $100 million mark after doing just $10 million in business in the same period of 2019.

Image source: Getty Images.

Some fear that now that coronavirus vaccines are available, Fulgent will see its COVID-19 testing fall off a cliff. However, with the rollout of vaccines going at a slower pace than many had hoped for, there'll still be plenty of need for coronavirus tests well into 2021. And more importantly, with Fulgent having demonstrated its ability to respond quickly in a crisis, the company has made valuable contacts in the healthcare and insurance industries that should serve to produce further growth opportunities in the years to come.

Fulgent has more than quadrupled investors' money in 2020. It might not jump another 300% or more in 2021, but the genetic-testing specialist has plenty of chances to keep its stock moving higher.

Shares of Celsius Holdings fared even better, rising more than 13% at midday. That's consistent with what's been an amazing year for the energy-drink specialist, with its stock jumping to more than 10 times where it started the year.

The latest surge for Celsius came as a result of a move from index managers at S&P Dow Jones Indices. Celsius will join the S&P SmallCap 600 Index effective as of Jan. 7. The move stems from an acquisition involving a company in the S&P 500, which created a cascade effect that eventually created a vacancy in the small-cap index.

Celsius joined a highly competitive arena with its energy drinks, but the company's focus on fitness and performance resonated well with consumers. Revenue has jumped more than fivefold in less than four years, and Celsius turned profitable in 2019 and has managed to maintain its bottom-line strength, even in the difficult current environment. That's a big part of what's attracting attention for the company, and it holds the key to Celsius' future success.

Investors must not get used to seeing stocks climb 300%, 500%, or even 1,000% in a year. However, when it happens, it often signals strength that will continue. Investors should expect to see more good things from Celsius and Fulgent in 2021.

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Take a deep breath 2020 is over and a new year has just begun. After months of fear caused by the Covid-19 pandemic, its time to turn the page, look ahead and start taking care of yourself. And weve got all the info you need to do just that. From enrolling in a Zoom fitness class to consulting with a genetic counselor, weve compiled dozens of ways for you to make 2021 your healthiest, and best, year ever.

For local fitness instructors, offering workout routines through Zoom or other video platforms has been a godsend during the pandemic. The technology allows them to reach clients who dont feel comfortable coming to the gym, and it also makes it harder to wiggle out of a workout. Running late and dont have time to drive to the gym? That excuse wont cut it anymore.

Many local fitness studios, like Chica Boom Fitness and Anytime Fitness, have begun offering workouts on Zoom or Facebook. Local trainers will guide you through daily workouts that mix weight training for specific muscle groups and both high- and low-impact cardio workouts.

Some even offer creative substitutions if you lack the necessary workout gear at home. Dont have kettlebells? Grab two full gallon water jugs instead. Dani Williams, who owns Nxt Generation, a fitness company that offers classes at the Sarasota studio Definition Fit, says Zoom classes offer flexibility for both the trainer and the client.

Williams works primarily with children and young adults, many of whom have special needs. Remote classes make it easier for them to show up each week, wherever they are. Travel is a big thing that prevents people from keeping a routine, says Williams. Its a really nice feature to have.

Even once the pandemic passes, Williams thinks remote fitness lessons will only grow in popularity. Local athletes can train with coaches all over the world, and local trainers can reach customers anywhere. Ive found great success with it, Williams says. Cooper Levey-Baker

Sarasota counselor Audrey Oxenhorn says committing to regular appointments with a therapist can make a huge difference in ones mental health, but the real work happens in between those meetings. An hour a week is never enough, says Oxenhorn.

To help people stay on track, Oxenhorn often recommends The Tapping Solution, an app that guides people as they tap on specific acupressure points on their body. The tapping, combined with calming sounds and words, is intended to reduce stress and anxiety. The app relies on a method that has been around for decades, but it has made it more accessible for millions of people. The technique and the app dont work for all of Oxenhorns clients. But when it does, its spectacular, she says.

The Tapping Solution is only one of dozens of apps that offer guided meditations and other programs that target anxiety, stress, fear, anger and other negative emotions. Headspace, for example, claims it has more than 65 million users in 190 countries, and has partnered with major companies like Nike and Starbucks. Other popular options include Moodfit, Sanvello and Happify.

According to Oxenhorn, apps make it easier for people struggling with mental health to take that first difficult step toward getting help and they give them tools to improve their mental health outside of a therapists office. I especially want to teach people to do the work themselves, so they can be happier and more fulfilled in what they do, Oxenhorn says. Cooper Levey-Baker

More and more people who have trouble falling, and staying, asleep are turning to melatonin, but does it work? According to Dr. Glenn Adams, a sleep medicine specialist and the medical director for Sarasota Memorials Sleep Disorder Center, the answer is: sometimes, for some people.

Melatonin is a naturally occurring substance in humans. Levels typically rise when it gets dark, cueing our bodies that its time for sleep. But as we grow older, our bodies produce less. At a young age, we have more than enough melatonin, says Adams. When youre 20 or 30, any benefits of taking it will be placebo.

Adams says there are no rigorous studies about melatonins benefits, but some do show that it may help you fall asleep 15 minutes sooner. That might help if it normally takes you 30 minutes to fall asleep, but if it usually takes you two hours, the benefit may be minimal.

With over-the-counter melatonin, the customer doesnt know exactly how many milligrams of melatonin he or she is getting, so Adams recommends sticking with the same brand for a consistent dosage. Side effects can be occasional nightmares, or even feeling a bit hungover when you wake up in the morning. If you do try melatonin, Adams says that once or twice is not enough to see if its working. Give it longer. Kay Kipling

Beet juice is the latest superfood to gain widespread attention, and whats not to like? Its low in caloriesone cup of beet juice has just 100 caloriesand its full of nitrates that improve your blood flow and help lower your blood pressure. According to one national study, people who drank beet juice for six days had better stamina to exercise more intensely.

Thats why its such a great pre-workout juice, says Lynn Morris, the owner of SaraFresh, which recently opened a retail store in the Rosemary District. SaraFresh specializes in cold-pressed juices, which have more nutritional value than pasteurized juices you find in the grocery store.

Morris says her new crowd favorite is something she calls Beetiful, a blend of beet, apple, lime and ginger, and she also offers 2.5-ounce beet shots. Shes also adding beet juice to her La Vie En Rose vegan ice cream to give it its signature rose color. By the way, dont panic if, after drinking beet juice, your urine turns reddish. Thats perfectly normal. Ilene Denton

Telemedicine has been around for years, but the Covid-19 pandemic has caused a massive rise in the number of doctors who offer consultations over the phone or through apps. But physicians cant take your vitals over the phone, so, more and more, they are relying on clients equipping themselves with tools to monitor their own data.

QardioArm, for example, is a home blood pressure monitor that delivers results to your phone and can share your numbers directly with your physician. Withings, meanwhile, is a smart scale that can also measure your bone, muscle and fat mass, and even adjusts for different gravity levels where you live to accurately determine your weight. Pulse oximeters that measure the oxygen level in your blood have also been flying off the shelves since the arrival of the coronavirus, as have affordable no-touch thermometers that read your temperature by scanning your forehead. Cooper Levey-Baker

At Scorch Fitnesswhich specializes in HIIT, or high-intensity interval traininga typical in-person session might last 45 to 50 minutes. But even workouts as short as 10 minutes can yield results, says Scorch owner Liz Lowe. Such brief sessions are known as micro HIIT workouts and are done at your own home. No instructor is needed. Just pick a combination of workouts (squats, a forearm plank and mountain climbers, for example) and get to work.

Micro HIIT workouts have become an increasingly popular way for people to squeeze in a good sweat between Zoom meetings, picking up the kids and running errands. I think micro HIIT is great for people who are strapped for time or if youre just getting into training, Lowe says.HIIT works by combining aerobic and anaerobic exercises that get your heart rate soaring, then alternating those with shorter periods of less strenuous activity. The Scorch program was adapted from workouts Lowe created for professional athletes, and it is designed to help you simultaneously burn body fat, add muscle and increase your resting metabolism. Micro HIIT exercises do the same thing, just in briefer windows of time.

If youre interested in trying them, Lowe recommends starting by finding exercises that just use your body weight. If you reach a point where you want to begin using weights, she recommends consulting with a trainer to make sure your form is correct. The last thing you want to do is get injured, Lowe says. Cooper Levey-Baker

When people talk about gut health, theyre not just talking about your stomach. The term gut refers to your whole gastrointestinal tract, which is covered in trillions of microscopic living organisms that help regulate a host of bodily systems, including immunity and weight.

But maintaining a healthy gut isnt always easy. Tens of millions of Americans suffer from digestive conditions like irritable bowel syndrome, nausea, bloating and constipation.

Gastroenterologist Nihar Shah of First Physicians Group says you can keep your gut healthy by eating foods rich in pre- and probiotics, such as apples, garlic, sweet potatoes, oats, chia seeds, onions, berries, kimchi, pickles, sauerkraut and yogurt. Shah also recommends colonoscopies once every 10 years once you reach 50 to screen for colon cancer. A healthy gut can play a role in preventing that, too.

Theres a direct link between colon cancer and consuming red meat and processed meat, so I recommend decreasing both of those things, as well as processed and genetically modified foods, says Shah. Also important: maintaining a healthy weight, getting a good nights sleep and exercising regularly.

And if youre taking any antibiotics, make sure to supplement your diet with those probiotic-rich foods, which can wipe out the good bacteria thats so important to a healthy gut. Megan McDonald

Over the last 20 years, genetic testing has emerged as a valuable tool for analyzing and even mitigating all kinds of medical conditionsincluding cancer. But testing is more road map than crystal ball. Nothing is definite. Everything is just about risk, says Nicole Wood, the oncology genetic counselor for Sarasota Memorials Genetic Testing for Hereditary Cancer program.

The genetic testing process begins with an extensive conversation with a genetic counselor, who will ask about your own medical history as well as your familys. If you opt for a genetic test, it only requires a blood draw.

[Your genetic makeup] is not new. Its something youve always carried since birth, says Wood. We use it to modify what were doing with your cancer care, screening, medical management, etc. Whatever train youre on that might lead to cancer, we can redirect it.

Still, genetic testing isnt for everyone, and theres good reason not to rush out and get tested willy-nilly. Once you know this information, you cant un-know it, says Wood.

Genetic testing technology continues to evolve at warp speed. Wood estimates that the number of genes that can be tested for cancer risk will double in two years. Wood even sees the probability of genetic manipulation in the future. Can we change these genes? she asks. Maybe." Hannah Wallace

Fitness experts say switching up your workouts is a good thing. You wont risk repetitive injuries and youll stimulate your brain at the same time. Foil boarding, a combination of windsurfing and wakeboarding, fits the bill.

Foil boarding starts with the hydrofoil, a wing-like structure that extends below the board into the water and lifts the board up so the rider looks like she (or he) is soaring a couple of feet above the water. This propeller allows riders to achieve speeds six knots faster than recorded gusts on a windy day. Add a parachute, and riders can really fly. The sport has become popular along the Gulf Coast, where youll spot riders levitating and landing tricks.

If youre looking to give it a try, you can purchase a board from the Venice board-making company Phase Five. The company has three different boards to choose from: the Gizmo ($1,270), the Chip ($1,270) and the Gadget ($989), which range from 44 to 54 inches long. Beginners should start with a longer board and foot straps to assist with training. Experienced surfers can try out shorter boards to glide through the air and land tricks. Allison Forsyth

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Genetics is a high tech, research-intensive business. Between the complexity of the science and the demands of the clinical trials and regulatory approval process, it's also quite risky -- but the rewards can be immense.

Many genetics companies spent the year working on the projects that might become their first sources of revenue. The market reacted to their every peep, and there's a good chance that several of these stocks will have another bumper crop year in 2021.

Image source: Getty Images.

Selling coronavirus diagnostic tests is big business, as shown by the 990% rise of Co-Diagnostics (NASDAQ:CODX) this year. With quarterly revenue growth exceeding 52,559% year over year, it's easy to see why the market was so enthusiastic about the company. Moving forward, it will penetrate foreign markets like India, selling tens of millions of its molecular test kits in the process.

Furthermore, Co-Diagnostics is moving quickly to develop new genetic tests that can detect viral mutations for the laboratory research market, ensuring that it will stay relevant through next year and beyond. Investors should look forward to another great year in 2021, with the caveat that it'll be tough to grow nearly as quickly as it did this year now that the testing market is significantly more crowded with competitors.

Arcturus Therapeutics (NASDAQ:ARCT) surged nearly 300% in 2020 by advancing its mRNA-based coronavirus vaccine program, which should enter phase 2 of its clinical trials in the first quarter of 2021. Though its candidate isn't as closely watched as several of the other leading contenders, there's a lot riding on its success. Like many biotech companies, it doesn't have any products on the market or any recurring revenue to speak of. That might change next year if its vaccine is proven effective. But, the early signs don't look good. A recent clinical update showed that its candidate might not be as protective as the other mRNA vaccines that are already approved for sale.

Investors can take heart in the fact that with just over $307 million in cash, Arcturus has enough gas in the tank to explore a few options for boosting the vaccine's efficacy. Until then, they can sit pretty on the stock's growth this year. If you're interested in investing, the only thing to do at the moment is to watch for clinical trial updates to see how its core project is advancing.

Given how many hopes were riding on its coronavirus vaccine candidate, you shouldn't be surprised to see Moderna (NASDAQ:MRNA) on this list. With growth of around 467%, Moderna will likely turn a profit for the first time next year as its vaccines are sold at mass scale. But, its stock may not be able to keep up with the valuations that 2020 built with hype.

Whether its first earnings reports in the new year will herald a reckoning is anyone's guess. Nonetheless, in the long-term its older pipeline projects will start to come to fruition. Some of those have the potential to be hugely disruptive, like its personalized cancer vaccine collaboration with Merck. Others, like its cytomegalovirus vaccine, may not make a big splash. Investors should watch the company's pipeline updates carefully, not to mention its earnings reports. There's every indication that its vaccine will be a big moneymaker, potentially to the tune of $32 billion in 2021. So, the real question is: What management will choose to spend the windfall on?

CODX data by YCharts

Inovio Pharmaceuticals (NASDAQ:INO) grew by 173% this year thanks to its coronavirus vaccine program. Like Moderna, Inovio's pipeline also has a smattering of lesser-known vaccines in development, none of which garnered the market's attention very much. Until this year, that is. Once the U.S. government's vaccine accelerator program invested in Inovio, it quickly entered the spotlight.

There's reason to be excited about Inovio moving forward, too. In mid-December, it announced that the government had taken an interest in developing a DNA-encoded monoclonal antibody therapy for COVID-19 using the company's technology. Likewise, its vaccine administration device developed with public funding may be key to its future success. Still, its coronavirus programs need to be proven definitively in clinical trials next year if its stock is to grow any further, and doubts remain about the viability of its DNA-based vaccines.

Thanks to hot demand for its coronavirus diagnostic products, Fulgent Genetics (NASDAQ:FLGT) grew by 280% in 2020, and its management increased its full-year revenue guidance by $100 million in November. Its revenue expanded by more than 880% in the third quarter compared to 2019, and the company is firmly profitable. Plus, its $2.74 million in debt barely holds a candle to its trailing revenue in excess of $135 million. There's a lot for investors to like, to say the least.

There's more to the company than its coronavirus tests, however. It also offers genetic testing for a handful of hereditary cancers and other disorders. Further investment in expanding its market penetration with these products will help to keep the company's momentum next year and beyond. In the meantime, investors can look forward to the next quarterly earnings report, which almost certainly will have even more good news.

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Genetic Testing Services Market Overview:

Research report on the Genetic Testing Services market by Market Growth Insight covers deep analysis on key factors that help business players to plan their future actions accordingly. The Genetic Testing Services market report discloses vital information like market share, market size, and growth rate for the forecast period 2020- 2026. The report on Genetic Testing Services market also comprises information on the stringent government regulations in key regions, such as import and export status, product price, FDA approvals, consumer buying behavior, Further the Genetic Testing Services market is categorized on the basis of product, end use industries, and region.

Global Genetic Testing Services market is anticipated to reach USD XX billion by the end of 2020 along with CAGR of XX % over the forecast period 2020 2026.

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Global Genetic Testing Services Market segments by Manufacturers:

Major Type of Genetic Testing Services Market Covered:

Application Segments Covered in Market

COVID-19 Analysis:

The disturbances caused by the novel Coronavirus is being witnessed by all the industries. Some of the major interruptions include cancellations of flights, disruptions in logistics, reduced demand and production, delayed supply of essential raw materials, rejected delivery of key components to the end use industries, increased panic among consumers, higher pressure on healthcare industry, and more. Several key regions are also experiencing prolonged lockdown due to speedy spread of the virus. Also businesses are witnessing many disturbances including delayed product launches, interruptions in innovations, and less working population in work areas. Nevertheless, researchers have mentioned about the strategies adopted by key vendors during pandemic and other planning and activities to alleviate the Genetic Testing Services market post-pandemic.

The Genetic Testing Services market discusses details on the leading product type. The Genetic Testing Services report also offers deep analysis on the potential product segment that is expected to lead in the forthcoming years. Also, information on other product segments is given in the Genetic Testing Services market report to help the competitors and customers get a clear picture of the market and details on the upcoming product, respectively.

The Genetic Testing Services market research report provides detailed information on the dominating end use industry that demand the product on a larger scale along with details on the potential end use industry that is anticipated to surpass the demand of the current prominent end use Genetic Testing Services industry.

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Regional Analysis of Genetic Testing Services Market Research Report:

The Genetic Testing Services market report is segmented as North America, Latin America, Asia Pacific, Europe, and Middle East and Africa. These regions are described well and elaborated with demographic insights and potential lucrative regions for the business owners to tap and expand their business geographically. This will also help the producers to understand the demands of consumers in a better way and manufacture goods accordingly.

In addition, competitive analysis is also precisely mentioned in the Genetic Testing Services report to help the new entrants plan effective establishment policies and approaches and gain prominent position among competitors. The commonly adopted growth strategies are also included in the Genetic Testing Services market report. Also, the existing players can plan effective approaches for future and gain leading ranking.

Some of the queries answered in the report comprise:

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Predictive Genetic Testing and Consumer/Wellness Genomics Market: Snapshot

Genetic testing comprises examination of ones DNA. The term DNA refers to the chemical database that is responsible for conveying the instructions for functions that need to be performed by the body. Genetic testing is capable of revealing changes or mutations in the genes of living beings, which might result in any kind of disease or illness in the body.

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Predictive genetic testingrefers to the utilization of genetic testing methods in an asymptomatic individual to make a prediction about risk of contacting particular disease in future. These tests are regarded as representation of emerging class of medical tests, which differ in fundamental ways from the usual diagnostic tests.

The global predictive genetic testing and consumer/wellness genomics marketis likely to gather momentum owing to the benefits offered by predictive genetic testing.

The benefits of predictive genetic testing are

The global predictive genetic testing and consumer/wellness genomics marketis influenced by reducing cost of genetic sequencing and technological advancement in the field of genetics. North America is expected to emerge as a prominent region for the global predictive genetic testing and consumer/wellness genomics market in years to come due to high adoption rates of latest technologies in all fields.

Over centauries human DNA has undergone tremendous alteration due to evolutionary and lifestyle changes. They have led to both, advantages and disadvantages over the years. Some have given the mankind a deserving edge over other creatures while the others have led to disorders and diseases. Predictive genetic testing and consumer/wellness genomics market thrives on the growing demand for understanding the lineage of a certain gene pool to identify disorders that could manifest in the later or early stage of a human life. The surging demand for understanding the family history or studying the nature of certain diseases has given the global market for predictive genetic testing and consumer/wellness genomics market adequate fodder for growth in the past few years.

This new class of medical tests are aimed at reducing the risk of morbidity and mortality amongst consumers. The thorough surveillance and screening of a certain gene pool can allow an individual to avoid conditions that disrupt normal existence through preventive measures. The clinical utility of these tests remains unassessed. Therefore, increasing research and development by pharmaceutical companies to develop new drugs by understanding diseases and disorders is expected to favor market growth.

Unlike conventional diagnostic testing, predictive genetic testing identifies the risk associated with potential conditions. In certain cases it is also capable of stating when the disease may appear and the how severe will it be. Thus, this form of testing is expected to allow consumers to take up wellness measurements well in time to lead a life of normalcy, characterized by good health.

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Global Predictive Genetic Testing and Consumer/Wellness Genomics Market: Overview

Predictive genetic testing are used to identify gene mutations pertaining to the disorders that surface at a considerably later stage in life after birth. These tests are particularly beneficial for people from a family with a history of genetic disorder, although they themselves show no symptoms of the disorder at the time of testing. Genetic testing promises to revolutionize the healthcare sector, providing crucial diagnostic details related to diverse verticals such as heart disease, autism, and cancer. As the healthcare sector touches new peaks, the global predictive genetic testing and consumer/wellness genomics market is projected to expand at a healthy growth rate during the forecast period of 2017 to 2025.

This report on the global market for predictive genetic testing and consumer/wellness genomics analyzes all the important factors that may influence the demand in the near future and forecasts the condition of the market until 2025. It has been created using proven research methodologies such as SWOT analysis and Porters five forces. One of the key aspect of the report is the section on company profiles, wherein several leading players have been estimated for their market share and analyzed for their geographical presence, product portfolio, and recent strategic developments such as mergers, acquisitions, and collaborations.

The global predictive genetic testing and consumer/wellness genomics market, on the basis of test type, can be segmented into predictive testing, consumer genomics, and wellness genetics. The segment of predictive testing can be sub-segmented into genetic susceptibility test, predictive diagnostics, and population screening programs, whereas the segment of wellness genetics can be further divided into nutria genetics, skin and metabolism genetics, and others.

By application, the market can be segmented into breast and ovarian cancer screening, cardiovascular screening, diabetic screening and monitoring, colon cancer screening, Parkinsons or Alzheimers disease, urologic screening or prostate cancer screening, orthopedic and musculoskeletal screening, and other cancer screening. Geographically, the report studies the opportunities available in regions such as Asia Pacific, Europe, North America, and the Middle East and Africa.

Global Predictive Genetic Testing and Consumer/Wellness Genomics Market: Trends and Opportunities

Increasing number of novel partnership models, rapidly decreasing cost of genetic sequencing, and introduction of fragmented point-solutions across the genomics value chain as well as technological advancements in cloud computing and data integration are some of the key factors driving the market. On the other hand, the absence of well-defined regulatory framework, low adoption rate, and ethical concerns regarding the implementation, are expected to hinder the growth rate during the forecast period. Each of these factors have been analyzed in the report and their respective impacts have been anticipated.

Currently, the segment of predictive genetic cardiovascular screening accounts for the maximum demand, and increased investments in the field is expected to maintain it as most lucrative segment. On the other hand, more than 70 companies are currently engaged in nutrigenomics, which is expected to further expand the market.

Global Predictive Genetic Testing and Consumer/Wellness Genomics Market: Regional Outlook

Owing to robust healthcare infrastructure, prevalence of cardiovascular diseases, and high adoptability rate of new technology makes North America the most lucrative region, with most of the demand coming from the country of the U.S. and Canada. Several U.S. companies hold patents, which further extends the outreach of the market in the region of North America.

Companies mentioned in the research report

23andMe, Inc, BGI, Genesis Genetics, Illumina, Inc, Myriad Genetics, Inc, Pathway Genomics, Color Genomics Inc., and ARUP Laboratories are some of the key companies currently operating in global predictive genetic testing and consumer/wellness genomics market. Various forms of strategic partnerships with operating company and smaller vendors with novel ideas helps these leading players maintain their position in the market.

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The market research report contains important details regarding the Predictive Genetic Testing market value based on market dynamics and various growth factors. It examines various key aspects of the market, including the latest technological innovations in the industry, current trends, and development opportunities. In this report, we analyze the Predictive Genetic Testing industry from two aspects. One part is about its production and the other part is about its consumption. In terms of its production, we analyze the production, revenue, gross margin of its main manufacturers and the unit price that they offer in different regions. In terms of its consumption, we analyze the consumption volume, consumption value, sale price, import and export in different regions at the same time, we classify different Predictive Genetic Testing based on their definitions. Upstream raw materials, equipment and downstream consumers analysis is also carried out. What is more, the Predictive Genetic Testing industry development trends and marketing channels are analyzed. In addition, this report introduces market competition situation among the vendors and company profile, and besides market price analysis and value chain features are covered in this report.

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The report represents the exact condition of the current market which includes Business Opportunity, Innovations, Upcoming-Trends, Growth-Analysis, Demand-Insight, Top-Manufacturers for the forecast year 2020 to 2025. Our board of exchange experts has immense enormous endeavors in doing this gathering activity so as to deliver important and dependable essential and optional information with respect to the Predictive Genetic Testing market.

Essential Key Players involved in Global Predictive Genetic Testing Market are:

Agilent, Technologies, Inc., BGI Genomics, F.Hoffman-La Roche Ltd., Genes In Life., Invitae Corporation, Illumina, Inc., 23andMe, Myriad Genetics, Inc., Pathway Genomics and Thermo Fisher Scientific, Inc.

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The detailed information in this reports will help the companies to make informed Marketing strategies. Moreover, ultimate goal of Market research is to analyze how the Markets target group will obtain a product or service. Market research report is predominantly prepared following certain methodology and guidelines for collecting, organizing and analyzing data. It also delivers the business models, strategies, growth, innovations and every information about key manufacturers that will enable in making business estimates. In addition, every Market has a set of manufacturers, vendors and consumers that define the Market as well as their every moves and achievements becomes a subject of studying for Market analysts.

Global Predictive Genetic Testing Market: Understanding ScopeBearing in mind the need for reader convenience, seasoned researchers of our in-house teams have identified 2020 as the base year and pinned the years between 2020-25 as the overall growth span. This is likely to give a glimpse of both the past and current happenings that systematically influence forecast estimation. Additionally, the report also takes into account the CAGR estimation and percentage that is likely to remain optimistic through the forecast span.

Market SegmentationMarket by Types

by Types (Predispositional Testing and Presymptomatic Testing), by Demographics (<35, 35 ? 64 and 65+)

An Overview of Regional Developments: Global Predictive Genetic Testing Market The overall spectrum of the global Predictive Genetic Testing market is broadly diversified into North and South America, Europe, APAC, and MEA. The report gauges into vital details such as manufacturer performance and overall growth activities across potent growth hubs. A close review of the overall growth rate during both past and current timelines have been meticulously highlighted to encourage thoughtful business decisions in global Predictive Genetic Testing market A clear reference of the overall revenue generation, sales performance as well as growth rate synopsis have been thoroughly structured in this versatile research report on global Predictive Genetic Testing market. Further in the report, readers are presented with substantia, cues on vendor landscape, frontline players and their company profiles and performance analysis have all been optimally highlighted in this report to encourage adequate reader discretion.

Chief Reasons for Report Investment The report lends a highly time specific, forward-looking scenario of the global Predictive Genetic Testing market The report offers a highly systematic overview of DROT analysis, involving detailed explanation of key market drivers, constraints, risks, and growth opportunities. The report also includes a complete five-year forecast assessment that allow manufacturers well gauge into futuristic growth probabilities The report is a handy-ready-to-refer guide to emphasize workability and growth potential of each of the segments, allowing readers to comprehend the investment potential of each segment. The report is an indispensable guide to understand and carry out a pin-point analysis of the fast-changing competitive landscape to encourage well informed business decisions favoring sustainability and long-term revenue generation potential in global Predictive Genetic Testing market.

3-Pointer Evaluation of COVID-19 Impact The report renders a thoroughly evaluated market outlook of the world perspective and the overall economic overview Stark differences and alterations in demand and supply chains have been highlighted A crisp pre and post COVID-19 developments and beyond have also been tagged in this corporate report on global Predictive Genetic Testing market.

Considering the existing market scenario, our seasoned researchers and expert panelists have relied heavily on intense research practices to offer an extensive range of market predictions for an exhaustive clientele reference of dynamics, dominating global growth outlook in Predictive Genetic Testing market. The unprecedented outrage of COVID-19 pandemic has affected adversely several businesses across industries. We aim to offer highly reliable and relevant action plan to offset the implications for further growth spurt in global Predictive Genetic Testing market. Customization remains crucial decision maker that always keeps us most preferred market intelligence provider for a burgeoning clientele.

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Predictive Genetic Testing Market Size 2020, Global Trends, Industry Share, Growth Drivers, Business Opportunities and Demand Forecast to 2025 -...

Recommendation and review posted by Bethany Smith

New Jersey, United States,- The report, titled Preimplantation Genetic Testing Market Research Report is based on the extensive analysis of analysts and contains detailed information on the global market area. A detailed examination of the business landscape, as well as the essential parameters that shape the marketing matrix of the market, is included.

A thorough qualitative and quantitative study of the global market has been conducted in this report. The study takes into account various important aspects of the market by focusing on historical and forecast data. The report provides information on the SWOT analysis as well as Porters Five Forces Model and the PESTEL analysis.

The Preimplantation Genetic Testing Market research documentation provides details on drivers and restraints, regional growth opportunities, market size, as well as the spectrum of competition, prominent market candidates, and segment analysis.

The following Manufacturers are covered in this report:

The report aims to enumerate various data and updates related to the World Market while developing various growth opportunities that are believed to support the market growth at a significant rate during the forecast period. The report provides an insightful overview of the Preimplantation Genetic Testing market along with a well-summarized market definition and detailed industry scenario.

A comprehensive summary revolves around market dynamics. The segment encompasses insights into the drivers driving the growth of the Preimplantation Genetic Testing market, restrictive parameters, existing growth opportunities in the industry, and the numerous trends that define the global marketplace. The report also includes data on pricing models and a value chain analysis. The expected growth of the market during the analysis period based on the estimates and historical figures has also been factored into the study.

The Preimplantation Genetic Testing market report provides details of the expected CAGR recorded by the industry during the investigation period. Additionally, the report includes a number of technological advances and innovations that will boost the industrys prospects over the estimated period.

The report further studies the segmentation of the market based on product types offered in the market and their end-use/applications.

1.Label-Free Detection Market, By Technology:

1.Label-Free Detection Market, By Products:

3.Label-Free Detection Market, By End User:

4.Label-Free Detection Market, By Application:

Geographic Segmentation

The report offers an exhaustive assessment of different region-wise and country-wise Preimplantation Genetic Testing markets such as the U.S., Canada, Germany, France, U.K., Italy, Russia, China, Japan, South Korea, India, Australia, Taiwan, Indonesia, Thailand, Malaysia, Philippines, Vietnam, Mexico, Brazil, Turkey, Saudi Arabia, U.A.E, etc.

North America, Europe, Asia-Pacific, Latin America, The Middle East and Africa

What are the main takeaways from this report?

A comprehensive price analysis was carried out in relation to product area, range of applications and regional landscape A comprehensive round up of the key market players and leading companies operating in the Preimplantation Genetic Testing Market to understand the competitive perspective of the global marketplace Important information on the regulatory scenario that defines the market, as well as the inflow of investments from majority stakeholders in the world market An in-depth assessment of the various trends that are fueling overall market growth and their impact on global market projection and dynamics A descriptive guide that identifies the key aspects along with the many growth opportunities in the Preimplantation Genetic Testing market A detailed documentation of a wide variety of ongoing issues in the world market that will encourage important developments

Some Points from Table of Content

1. Study coverage2. Summary3. Preimplantation Genetic Testing Market Size by Manufacturer4. Production by region5. Consumption by region6.Preimplantation Genetic Testing Market Size by Type7. Preimplantation Genetic Testing Market size according to application8. Manufacturer profiles9. Production forecasts10. Consumption forecasts11. Analysis of customers upstream, industrial chain and downstream12. Opportunities and challenges, threats and influencing factors13. Main results14. Appendix

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Preimplantation Genetic Testing Market Size, Share, Growth Trends, Revenue, Top Companies, Regional Outlook, and Forecast, 2020-2027 - LionLowdown

Recommendation and review posted by Bethany Smith

A waning 2020 delivered a final kick on the way out Thursday with the county health department announcing 62 additional COVID-19 deaths, a new single-day record arriving on New Years Eve.

And there was an extra reason for concern. The county public health lab, working with local researchers, confirmed three more cases of the United Kingdom coronavirus strain Thursday, bringing the total to four, including the initial case involving a man in his 30s announced Wednesday.

Officials said none of the four are related and had no contact with each other before testing positive.

The three additional cases confirmed Thursday were all men. Case investigators have interviewed two of the three who reported no recent travel outside the country. Two of the three new cases were in their 40s and the third was in his 50s. The third case for whom travel information was not available had not yet been interviewed.

They live in La Mesa, Otay Mesa, Mission Beach and the Rancho Bernardo-Carmel Mountain area.

The county public health lab was still awaiting the results of genetic testing to confirm whether a close contact of Wednesdays first UK strain subject, who was said to have been experiencing symptoms of coronavirus infection, also has the UK strain.

Dr. Eric McDonald, medical director of the countys epidemiology department, said Thursday evening that the subject, a woman also in her 30s who is the spouse of Wednesdays UK case, has been admitted to a hospital after testing positive for coronavirus. Genetic testing being performed by Scripps Research will be necessary to confirm that the UK strain was involved, but that seems very likely at this point.

I would be shocked if it doesnt come back with whole-genome sequencing that confirms it, McDonald said.

He said the three additional UK cases confirmed through genetic testing Thursday were actually tested between Dec. 20 and Dec. 22. Helix, a local company that the county contracts with for testing, looked through its records after the first case appeared and discovered the results as having the telltale s drop signature that marked Wednesdays case.

Having cases from different parts of the county that did not know each other, he said, shows that this strain, which is thought to spread more easily than other variants, has been among us for some time.

This didnt just spread to that many different parts of the county among people who dont know each other in the past two weeks, McDonald said. The dispersal of these cases geographically tells you that it has probably been in the county for a longer period of time.

With 99 deaths announced in just the past two days, December is by far the deadliest month of the pandemic. According to county records, 488 deaths have been recorded in December, more than twice the previous monthly record of 197 tallied in July.

The most recent deaths announced Thursday range in age from 45 to 100 with three in their 40s. As is always the case, the deaths announced on any given day did not all occur the day before the announcement. It can take days or weeks for death certificates and causes of death to be finalized before they are reported to the public.

Taking the latest group into account, records show that a total of 28 deaths occurred on Dec. 22, tying Dec. 18 for the deadliest day of the pandemic.

McDonald said he reviews each and every death certificate before the county releases new numbers. Seeing so many in December, he said, has been particularly harrowing.

Every one of those is a person and has a family, McDonald said. What this means is that there are more and more San Diego families that are coming to grips with the fact that this is a real and deadly pandemic.

Deaths are what epidemiologists call a lagging indicator, generally occurring weeks or months after infections take hold. As such, a spike in deaths does not, in and of itself, say all that much about how a pathogen such as the novel coronavirus is spreading in a community. The number of new positive cases coming in daily provides a more immediate sense of the current pace of infection.

The final COVID-19 report of 2020 lists 3,083 new cases, once again jumping over the 3,000 mark after three straight days below that mark. The result could signal the arrival of a new wave of cases connected to Christmas celebrations, given that the average incubation period for the virus the amount of time spent in the body before symptoms generally begin to appear is about 6 days, according to the U.S. Centers for Disease Control and Prevention.

Pressure continues to mount on local hospitals with 1,580 total COVID-19 patients in beds across the county Wednesday. COVID-positive patients occupied 35 percent of the 4,504 total beds in use. Intensive care admissions held steady at 621 with 386 having a COVID-19 diagnosis and 235 without.

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San Diego County ends 2020 with largest single-day COVID-19 death total of the year - The San Diego Union-Tribune

Recommendation and review posted by Bethany Smith

The Direct Genetic Testing for Consumer Market report was conducted across a variety of businesses in various regions to produce a worthy report that represents the proficient analysis of the industry. The report provides a competitive study of leading market players, market growth, consumption (sales) volume, key drivers and limiting factors, future projections for the new-comer to plan their strategies for global Direct Genetic Testing for Consumer Market business. The report highlights key market expansions, industry and competitors challenges in gap analysis and new opportunities and key trends in the market. The report studies many aspects of the industry like the market size, market status, market trends and forecast from 2020 to 2026 time period.

Report Overview:

Report Ocean analysts monitoring the situation across the globe explains that the market will generate remunerative prospects for producers post COVID-19 crisis. The report aims to provide an additional illustration of the latest scenario, economic slowdown, and COVID-19 impact on the overall industry. We will also include the impact of COVID-19 new strain found in UK.

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The global Direct Genetic Testing for Consumer Market research study is to define market sizes of various segments & countries by past years and to forecast the values by next 5 years. The report is assembled to comprise each qualitative and quantitative elements of the industry facts including market share, market size (value and volume 2015-19, and forecast to 2026) which admire each country concerned in the competitive examination. Further, the study additionally caters the in-depth statistics about the crucial elements which includes drivers & restraining factors that defines future growth outlook of the market.

Competitive Landscape:

Competitive landscape of a market explains the competition in the Direct Genetic Testing for Consumer Market taking into consideration price, revenue, sales, and market share by company, market concentration rate, competitive situations, trends, and market shares of top companies. Strategies incorporated by key players of the market such as investment strategies, marketing strategies, and product development plans are also further included in the report. The research integrates data regarding the producers product range, top product applications, and product specifications.

The major players in the Direct Genetic Testing for Consumer Market are:

Market Segmentation:

The segmentation is used to decide the target market into smaller sections or segments like product type, application, and geographical regions to optimize marketing strategies, advertising technique and global as well as regional sales efforts of Direct Genetic Testing for Consumer Market.

Regional and Country-level Analysis

The market size information is provided by regions (countries) in the Direct Genetic Testing for Consumer Market report.

The key regions covered in the Direct Genetic Testing for Consumer Market report are North America, Europe, China and Japan. It also covers key regions (countries), viz, the U.S., Canada, Germany, France, U.K., Italy, Russia, China, Japan, South Korea, India, Australia, Taiwan, Indonesia, Thailand, Malaysia, Philippines, Vietnam, Mexico, Brazil, Turkey, Saudi Arabia, U.A.E, etc.

The report includes country-wise and region-wise market size for the period 2015-2026. It also includes market size and forecast by Type, and by Application segment in terms of production capacity, price and revenue for the period 2015-2026.

Tools Used for Analysis in This Report:

The Direct Genetic Testing for Consumer Market report has used analytical tools to include accurate research and evaluation data on key industry players and market coverage. Report Ocean experts have analyzed the growth of leading companies operating in the marketplace using analytics tools such as Porters five power analysis, SWOT analysis, feasibility study and ROI analysis.

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Table of content

1 Direct Genetic Testing for Consumer Market Overview

1.1 Product Overview and Scope of Direct Genetic Testing for Consumer

1.2 Direct Genetic Testing for Consumer Segment by Type

1.2.1 Global Direct Genetic Testing for Consumer Production Growth Rate Comparison by Type 2020 VS 2026

1.2.2 Diagnostic Screening

1.2.3 Prenatal, Newborn Screening, and Pre-Implantation Diagnosis

1.2.4 Relationship Testing

1.3 Direct Genetic Testing for Consumer Segment by Application

1.3.1 Direct Genetic Testing for Consumer Consumption Comparison by Application: 2020 VS 2026

1.3.2 Online

1.3.3 Offline

1.4 Global Direct Genetic Testing for Consumer Market by Region

1.4.1 Global Direct Genetic Testing for Consumer Market Size Estimates and Forecasts by Region: 2020 VS 2026

1.4.2 North America Estimates and Forecasts (2015-2026)

1.4.3 Europe Estimates and Forecasts (2015-2026)

1.4.4 China Estimates and Forecasts (2015-2026)

1.4.5 Japan Estimates and Forecasts (2015-2026)

1.5 Global Direct Genetic Testing for Consumer Growth Prospects

1.5.1 Global Direct Genetic Testing for Consumer Revenue Estimates and Forecasts (2015-2026)

1.5.2 Global Direct Genetic Testing for Consumer Production Capacity Estimates and Forecasts (2015-2026)

1.5.3 Global Direct Genetic Testing for Consumer Production Estimates and Forecasts (2015-2026)

1.6 Direct Genetic Testing for Consumer Industry

1.7 Direct Genetic Testing for Consumer Market Trends

2 Market Competition by Manufacturers

2.1 Global Direct Genetic Testing for Consumer Production Capacity Market Share by Manufacturers (2015-2020)

2.2 Global Direct Genetic Testing for Consumer Revenue Share by Manufacturers (2015-2020)

2.3 Market Share by Company Type (Tier 1, Tier 2 and Tier 3)

2.4 Global Direct Genetic Testing for Consumer Average Price by Manufacturers (2015-2020)

2.5 Manufacturers Direct Genetic Testing for Consumer Production Sites, Area Served, Product Types

2.6 Direct Genetic Testing for Consumer Market Competitive Situation and Trends

2.6.1 Direct Genetic Testing for Consumer Market Concentration Rate

2.6.2 Global Top 3 and Top 5 Players Market Share by Revenue

2.6.3 Mergers & Acquisitions, Expansion

3 Production and Capacity by Region

3.1 Global Production Capacity of Direct Genetic Testing for Consumer Market Share by Regions (2015-2020)

3.2 Global Direct Genetic Testing for Consumer Revenue Market Share by Regions (2015-2020)

3.3 Global Direct Genetic Testing for Consumer Production Capacity, Revenue, Price and Gross Margin (2015-2020)

3.4 North America Direct Genetic Testing for Consumer Production

3.4.1 North America Direct Genetic Testing for Consumer Production Growth Rate (2015-2020)

3.4.2 North America Direct Genetic Testing for Consumer Production Capacity, Revenue, Price and Gross Margin (2015-2020)

3.5 Europe Direct Genetic Testing for Consumer Production

3.5.1 Europe Direct Genetic Testing for Consumer Production Growth Rate (2015-2020)

3.5.2 Europe Direct Genetic Testing for Consumer Production Capacity, Revenue, Price and Gross Margin (2015-2020)

3.6 China Direct Genetic Testing for Consumer Production

3.6.1 China Direct Genetic Testing for Consumer Production Growth Rate (2015-2020)

3.6.2 China Direct Genetic Testing for Consumer Production Capacity, Revenue, Price and Gross Margin (2015-2020)

3.7 Japan Direct Genetic Testing for Consumer Production

3.7.1 Japan Direct Genetic Testing for Consumer Production Growth Rate (2015-2020)

3.7.2 Japan Direct Genetic Testing for Consumer Production Capacity, Revenue, Price and Gross Margin (2015-2020)

4 Global Direct Genetic Testing for Consumer Consumption by Regions

4.1 Global Direct Genetic Testing for Consumer Consumption by Regions

4.1.1 Global Direct Genetic Testing for Consumer Consumption by Region

4.1.2 Global Direct Genetic Testing for Consumer Consumption Market Share by Region

4.2 North America

4.2.1 North America Direct Genetic Testing for Consumer Consumption by Countries

4.2.2 U.S.

4.2.3 Canada

4.3 Europe

4.3.1 Europe Direct Genetic Testing for Consumer Consumption by Countries

4.3.2 Germany

4.3.3 France

4.3.4 U.K.

4.3.5 Italy

4.3.6 Russia

4.4 Asia Pacific

4.4.1 Asia Pacific Direct Genetic Testing for Consumer Consumption by Region

4.4.2 China

4.4.3 Japan

4.4.4 South Korea

4.4.5 Taiwan

4.4.6 Southeast Asia

4.4.7 India

4.4.8 Australia

4.5 Latin America

4.5.1 Latin America Direct Genetic Testing for Consumer Consumption by Countries

4.5.2 Mexico

4.5.3 Brazil

5 Direct Genetic Testing for Consumer Production, Revenue, Price Trend by Type

5.1 Global Direct Genetic Testing for Consumer Production Market Share by Type (2015-2020)

5.2 Global Direct Genetic Testing for Consumer Revenue Market Share by Type (2015-2020)

5.3 Global Direct Genetic Testing for Consumer Price by Type (2015-2020)

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Direct Genetic Testing for Consumer Market is expected to show impressive growth rate between 2020 to 2026 - LionLowdown

Recommendation and review posted by Bethany Smith

In her new book, Twelve Paintings, writerTal Sterngast explores Berlins Gemldegalerie, which is known for an exceptional collection of European paintings. She lands on twelve paintings from the collection and investigates the story behind them through important questions of today. In this chapter, called The Creativity of Women, Sterngast looks at the legacy of prominent French portraitist lisabeth Vige Le Brun, one of the few women artists in the Berlin state collection, asking what paradoxes exist within art that is made by women.

Born in 1755 in Paris to a painter and a hairdresser, Elisabeth Vige-Lebrun achieved success in France and Europe against the norms of the time during one of the most turbulent periods in European history. Her father, who recognized the daughters talent and passion early on, died when she was 12. In her feminist essay Why Have There Been No Great Women Artists? from 1971, the art historian Linda Nochlin noted that, denied access to workshops, academies, or universities, almost all women artists known to us before the 20th century had a father in the profession.

From around 2,800 paintings in Berlins Gemldegalerie collection made north and south of the Alps between the 13th and the 18th century, 15 were painted by nine women. With the exception of Italian Renaissance painter Sofonisba Anguissola, all of them came from the northern countries and lived around the 18th century. Vige-Lebrun learned to paint by looking at and copying art in Paris, and began working as a portraitist in her youth, supporting her widowed mother and brother for a time. Soon after encountering Marie Antoinette, she became her court painter, the first woman to attain this rank. Admitted to the Acadmie Royale de Peinture et de Sculpture (Royal Academy of Painting and Sculpture) at age 28, she became one of only four women members and one of the leading portraitists of the ancien rgime.

Neither boy nor girl, neither adult nor child; not completely human, animal, or divine, the prince holds a laurel wreath demonstratively in the air. It is an opening waiting to be breached, whereas the phallic quiver of arrows laying partially concealed at his feet is a latent weapon, a possible complement to entering the ring. Echoing this potential intercourse or coupling, the princes winged figure hybridizes classic mythology with Jewish-Christian motifs. Cupid-Erosthe mischievous god of love equipped here with arrows but no bow, a reminder of the ancient knot that ties love with a woundis combined with a Judeo-Christian angel: a cherub or seraph. The two cherubim in rabbinic literature are described as human-like entities with wings, placed on the opposite ends of the Ark of the Covenant in the inner sanctum of the temple, containing the two stone tablets of the Ten Commandments. Representing a threshold between profane and sacred, between the given world and the one beyond, they guard the law. Higher in ancient Judaism and Christianitys hierarchy of angels, the seraphim announces the sacred name of God and its distinction from its creations. These winged creatures separate and connect human and divine, man, and God.

lisabeth Vige-Lebruns Prince Heinrich Lubomirski as the Geniusof Fame (178788). Acquired in 1874 from the Gallery. Fr. Heim, Paris. Photo: Jrg P. Anders.

In Western iconography, the distinction between seraph and cherub echoes the broad division between faith and reason; cherubs, the former; seraphs, the latter. Cupid as cherub thus takes the pagan idea of a demigod and superimposes it on the Catholic notion of an angel of the sort linked with encouragement to faith as opposed to reason; the latter would be the seraphs concern. The hybridization of Cupid and cherub may therefore point to an aspiration of synthesizing desire and faith. Could it be that the little princes androgyny, with the ambiguities or thresholds it captures, reverberates the zeitgeist of drastic transformations? The revolutionary program of the period was marked byor part ofa secularization of the divine, the exchange of the metaphysics of religion with revolutionary ideas and the loss of the sacred. What exactly was Vige-Lebrun idolizing in her Lubomirski portrait?

The genius of love, disguised in a portrait of a boy, not only evokes a sense of immanentization (as Greco-Roman gods often do, anthropomorphized and restlessly intervening in human affairs) but also implies a certain diffusion or inversion within the active/passive oppositions of man and woman, artist and model, subject, and object. As a portraitist at a time when women were denied apprenticeships and forbidden from drawing nudes, Vige-Lebrun was aware of the power relations inherent to the gaze. In her memoir, she admits to flirting with her male sitters: As soon as I observed any intention on their part of making sheeps eyes at me, I would paint them looking in another direction than mine, and then, at the least movement of the pupilla, would say, I am doing the eyes now.

Even when women were already officially permitted at the School of Fine Arts in Paris (and in other European art schools) much later at the end of the 19th century, they were still not allowed to copy the naked body. That undressed, to-be-painted body was not only standing for painting itself and the speculation of a passivity/activity dichotomy, but also to the question of truth, the naked truth. That was the time when Friedrich Nietzsche stressed how much the questions of art, style, and truth can not be dissociated from the question of the woman. An answer to the question what is woman cannot be found in any of the familiar modes of concept or knowledge, he noted. Yet it is impossible to resist looking for her. Men, asserts French philosopher Genevive Fraisse, didnt want women involved in the question of beauty, because it is married to the question of truth. It belonged to men. Copying the naked body, therefore, is also about gaining access to the truth.

Is there a difference between feminine and masculine creativity? And if there is one, how is it to be argued? Nochlins essay laid ground for a feminist methodology in art history, claiming that this question was the wrong one to begin with. Acknowledging that there were no women equivalents for Michelangelo or Rembrandt, Czanne, Picasso, or Matisse, or even for de Kooning or Warhol, she made the point that the fault lay not in womens genetics, but rather in institutions and education. As well as that art is not a means of pure self-expression but rather something that involves a self-consistent language of form, given conventions, which must be learned through teaching or individual work. Women were consistently and systematically denied access to both. In addition, she criticized the myth of the innate genius as an atemporal and mysterious power, embedded in the person of the great artist, a godlike figure.

While Nochlin and much of feminist art history after her rightly stressed the importance of the institutional over the individual, the question that is asked too little today is not whether women can make art or not anymore, but if and how women can be creative without adopting masculine attributes, without being creative like a man. Does the fact that there is no female style in the works of great women artists from Artemisia Gentileschi to Agnes Martin mean that theres nothing in common among women artists? Can a woman artist define art anew in radicality like, for example, Diego Velazquez, Marcel Duchamp, or Andy Warhol, or is it a different game altogether? Can the creativity of women extricate itself from the metaphor, from being an image; one that belongs to the sphere of mere appearances and temptation, but also to nature and motherhood?

Agnes Martin Untitled I (1985). Courtesy of Phillips.

Between its two facetsthe monstrous imagination of an endless birth-giving, as opposed to a suffering of being as endurance, in absencewhat are the paradoxes within which art is made by women? Corresponding to the former is much of performance art by women since the 1970s, which relates to taboo aspects of bodies: menstrual blood, childbearing, excrement, internal organs; or, differently, art made by and after Louise Bourgeoiss surrealism, vividly feeding off trauma and lending unconscious visual tropes (stairs, spiders, cages) meaning that is both narrative and therapeutic. In correlation to the latter, one can think of Agnes Martins repetitive grids that achieve not what is seen, but what is known forever in the mind unfolding contemplative states of existence. Or Vija Celminss detailed drawings and paintings of starry skies, spider webs, or the ocean as surfaces of spiritual solitude and retinal allure.

If the domain of modern art and artifice is understood as a substitute for fecundity, an outcome of a creativity which is in its essence masculine, what art can be made in fertility? Asking this question might risk all that womens fight for equality has accomplished. However, not asking it might be denying the potentialities of art made by women as something that can best be described as total otherness in this given, androcentric world.

Tal Sterngaststudied photography and film in Jerusalem, London, and Berlin. She has published numerous essays and articles about contemporary art and film in international newspapers and art magazines. She has organized several exhibitions. Her newbook, out now in English and in German with publisher Hatje Cantz, is based on the article series Alte Meister, published in the weekend supplement of die Tageszeitung from 2017 until 2019.

More here:
A Look at the Subversive Art of lisabeth Vige Le Brunand the One Gender-Bending Portrait That Has Kept Historians Guessing - artnet News

Recommendation and review posted by Bethany Smith

Categories: -The Daily Gazette, High School Sports, Sports

Its always been big news when a player from Section II makes a commitment to join a Division I womens basketball program.

That happened seven times in recent months, a mass splurge that created a big story all of its own.

I remember when two or three was a good year, said former girls basketball coach Fran Pugliese, who began a 20-year stint at Draper and Columbia high schools back in 1977. Seven is amazing. Girls are playing so much now.

They are, and so many more will be joining in to compete, grow and be evaluated in places in and around the Capital Region that werent available not too long ago.

There were two AAU teams in this area when I was playing, said 1996 Burnt Hills-Ballston Lake graduate and current Niskayuna coach Sarah Neely. If you were lucky enough to make it.

Saratoga Springs coach and former Union College basketball standout Robin Chudy didnt even have that.

I played on a boys team that my dad coached, the 1988 Columbia graduate said. Back then, it wasnt huge.

The expansion of AAU programs and club teams in the area, and more recently organizations such as the Empire State Takeover, have helped change that.

There are more good players because there is more basketball available, former Shenendehowa girls coach Ken Strube said.

Section II has never seen a senior class of Division I commits quite like this one in respect to its large number and record of achievement. The all-star cast features Meghan Huerter of Shenendehowa (Providence), Niskayunas Olivia Olsen (Providence), state champion Cambridge twins Lilly Phillips (UAlbany) and Sophie Phillips (Rhode Island), Antonia May of Amsterdam (UMBC), Valencia Fontenelle-Posson of Guilderland (Siena) and Maddisyn Mahoney of Shaker (Fairleigh Dickinson).

Whether those players get a chance to play this winter season remains in question with COVID-19 cases on the rise and the high risk sport of basketball on hold in New York. Their level of dedication and talent, however, is without question.

The Capital Region has consistently produced some of the strongest players in upstate New York, but this is a special class, Empire State Takeover founder and director Jeff Mlinar said. Theyve all put in a ridiculous amount of work to get where they are.

All of them have been through the travel ball route and participated in Empire State Takeover activities that include league play and college showcase events. Family genetics and a large dose of family support, Mlinar noted, played a part in those Division I scholarships, too.

It shows that there are a lot of hard workers in the area, Lilly Phillips said of Section IIs Division I-bound class. It shows that our age group really loves basketball.

I think we started young and had a passion for basketball to get where we are now, Fontenelle-Posson said.

Mlinar said more Division I talent from Section II is on the way.

More girls are going to the scholarship level, said Mlinar, who will be entering his seventh year working with upstate girls. We will have another solid class next year and another one in 2023. We are trending in the right direction and I think well continue to do that. Some classes will be bigger than others.

Rhaymi Porter of Scotia, who will play at Division I Canisius after her 2021 graduation from Wilbraham & Monson Academy in Massachusetts, is another product of the Empire State Takeover program and the travel ball circuit.

There are more opportunities for girls to be in the gym, and develop and be seen, Mlinar said. A big point is they are getting the opportunity to do it at a younger age.

This class has been blessed to have the opportunities weve had, said Fontenelle-Posson, who joined the City Rocks AAU program when she was in third grade. Forty or 50 years ago, they didnt have that.

Shenendehowa was one of Section IIs first schools to reap the rewards of a strong youth program in terms of wins and championships on the court, and Divison I college scholarships to the player that made it happen, some of the earliest being 1988 graduate Wendy Czelusniak (New Mexico State), and 1990 twin graduates Laura and Debbie Barnes (Richmond).

Several more Division I players followed during the Strube era including Jen Scanlon (1992, Duke), who, like Debbie Barnes, earned the New York Miss Basketball award during her senior year. State career scoring leader Caryn Schoff of St. Johnsville (1995, Syracuse) and Carolyn Gottstein of Albany (2000, Boston College) would later garner that award, as well.

We had a ridiculous youth feeder program, said Strube, who won four state titles and 10 Section II championships in his coaching run at Shenendehowa from 1979-2012. The cool thing was the dads didnt just focus on their daughters. They developed the whole program, and I got the credit.

When I started out, they didnt start until high school, Pugliese said of his early groups at Draper. Theyre playing in third and fourth grade now.

I just think if you look at the 80s and 90s, girls sports started to evolve, Neely said. There are so many opportunities for female athletes in so many sports.

In more recent years, single-sport specialization has become more common among female athletes, weight rooms have became more available and personal trainers and coaches have became more prevalent.

Everything plays a role, Mlinar said.

Increased exposure of different kinds has also aided both players and college coaches in the recruiting process.

I remember when [former Daily Gazette sports editor] Butch Walker asked me if I wanted to cover a Bishop Gibbons girls basketball game. We had never done that before, said Bill Buell, a Gazette sportswriter from 1978 through 2002. The rest is history. A few years later, we put out our first Gazette All-Area girls basketball team.

Buell covered that initial girls game during the 1983-84 season, three years after the first NCAA Division I womens basketball tournament was staged, and a decade after Ann Meyers became the first female basketball player in the United States to get a four-year athletic scholarship from UCLA.

We always had a few good players, Buell said of his early years with the newspaper. The mindset was different then. Most girls didnt think about getting Division I scholarships.

Buell said star players such as Shawn Shafer, who went from Bishop Gibbons to Siena in 1986, Tanya Hansen, who went from Albany to Rutgers in 1988, and Anita Kaplan, who went from Bethlehem to Stanford in 1991, helped change that thought process.

Kaplan was in the national spotlight her freshman season when she played a role in Stanfords NCAA Division I championship. (That team, of course, was coached by Schenectady County native and all-time womens college basketball wins leader Tara VanDerveer, who struggled to find girls teams to play for in her youth.)

Once those girls started getting some publicity, others thought, We can do that, too,' Buell said. This avenue is open to me.'

Chudy saw youngsters flock to 2020 graduate Dolly Cairns, Saratoga Springs career points leader who is playing at Rhode Island, and 2019 grad Kerry Flaherty, who is competing at Holy Cross.

The neat part is watching the younger kids who want to emulate them, said Robin Chudy, whose team includes her daughter, sophomore Natasha Chudy one of Section IIs rising stars.

Fontenelle-Posson knows younger eyes are on her, as her own were on 2018 Niskayuna graduate Olivia Owens, who is currently playing at Kentucky after spending time with the Maryland program.

I watched her for a long time and still keep tabs on how she is doing, Fontenelle-Posson said. Its a cycle. Now its my turn to try to set an example so the younger girls can see what can happen with hard work.

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Big rewards for Section II girls as basketball avenues increase - The Daily Gazette

Recommendation and review posted by Bethany Smith

January

4 Winners of five Costa category awards announced.8 The Father released Florian Zeller directs an adaptation of his own play, starring Anthony Hopkins.11 TS Eliot prize for poetry.19 Centenary of the birth of Patricia Highsmith, queen of psychological suspense.22 Netflix adaptation of Aravind Adigas Booker winner The White Tiger.Release of film Chaos Walking, based on first book of Patrick Nesss eponymous trilogy.26 Costa awards ceremony, with book of the year announced.

Fiction

Luster by Raven Leilani (Picador)In the years buzziest debut, a black American millennial tackles the difficulties of work, love, sex and being seen for who you really are.

The Living Sea of Waking Dreams by Richard Flanagan (Chatto & Windus)A family grapples with mortality while Australia burns, in a magical realist fable about extinction and Anthropocene despair from the Booker-winning author of The Narrow Road to the Deep North.

Memorial by Bryan Washington (Atlantic)His story collection Lot won last years Dylan Thomas prize; this deft debut novel explores the complications of family and a gay relationship on the rocks.

A Burning by Megha Majumdar (Scribner)Three lives entangle in contemporary India, in a debut about class and aspiration that has been a sensation in the US.

The Art of Falling by Danielle McLaughlin (John Murray)Debut novel about a woman rebuilding her marriage, from the celebrated Irish short story writer.

A River Called Time by Courttia Newland (Canongate)Ambitious speculative epic set in an alternate London where slavery and colonialism never happened.

People Like Her by Ellery Lloyd (Mantle)Smart, gobble-at-a-sitting thriller about life as a yummy mummy influencer and the dark side of Instagram.

Girl A by Abigail Dean (HarperCollins)Incendiary, beautifully written thriller debut about siblings living with the emotional legacy of childhood abuse in a House of Horrors.

The Stranger Times by CK McDonnell (Bantam)Pratchettesque romp set around a Manchester newspaper dedicated to the paranormal whose reporters get sucked into a battle between good and evil.

Childrens and teen

Amari and the Night Brothers by BB Alston (Egmont)Film rights have been snapped up for the first in a new supernatural adventure series with a black heroine.

Concrete Rose by Angie Thomas (Walker)From the US YA sensation, this hard-hitting prequel to the award-winning The Hate U Give focuses on Starrs father as a young man.

Poetry

Living Weapon by Rowan Ricardo Phillips (Faber)The award-winning American essayist and poets first collection to be published in the UK combines civic awareness with an interrogation of language and self.

Nonfiction

A Swim in a Pond in the Rain by George Saunders (Bloomsbury)The Booker-winning author of Lincoln in the Bardo considers the art of fiction through seven classic Russian short stories by Chekhov, Turgenev, Tolstoy and Gogol.

Francis Bacon: Revelations by Mark Stevens and Annalyn Swan (William Collins)A definitive biography, written with the full cooperation of the Bacon estate and with unrivalled access to the artists personal papers.

Begin Again: James Baldwins America by Eddie S Glaude Jr (Chatto & Windus)Exemplifying the resurgence of interest in Baldwin, this blend of biography, criticism and memoir with the novelist at its heart is an indictment of racial injustice in Trumps America.

Empireland: How Imperialism Has Shaped Modern Britain by Sathnam Sanghera (Viking)One of a new wave of books on British imperialism, this study, from the likable journalist and author of The Boy With the Topknot, looks at the legacy of empire from the NHS to Brexit and Covid.

Breathtaking: Inside the NHS in a Time of Pandemic by Rachel Clarke (Little, Brown)The palliative care doctor who scored a hit with her book Dear Life gives an insider account of hospital life as Covid-19 changed everything.

Saving Justice by James Comey (Macmillan)The former FBI director and author of A Higher Loyalty looks into how institutions of justice in the US were eroded during the Trump presidency.

The Unusual Suspect by Ben Machell (Canongate)The remarkable story of how a British student with Aspergers became obsessed with Robin Hood following the global financial crash, and began to rob banks.

4 Centenary of the birth of Betty Friedan, author of The Feminine Mystique.23 Bicentenary of the death of John Keats in Rome.

Fiction

Light Perpetual by Francis Spufford (Faber)The author of Golden Hill imagines the lost futures of children killed in the blitz, in a sparkling, humane panorama of miraculous everyday life.

No One Is Talking About This by Patricia Lockwood (Bloomsbury)Following her acclaimed comic memoir Priestdaddy, a fast and furious debut novel about being embedded deep in the digital world.

Mother for Dinner by Shalom Auslander (Picador)Outrageous comedy about identity politics and family ties centred on the Cannibal-American Seltzer clan.

We Are Not in the World by Conor OCallaghan (Transworld)Delayed from 2020, the examination of a father-daughter relationship by a rising Irish star.

Maxwells Demon by Steven Hall (Canongate)Long-awaited follow-up to ultra-inventive cult hit The Raw Shark Texts features a man being stalked by a fictional character.

Open Water by Caleb Azumah Nelson (Viking)Black British artists fall in love in an intense, elegant debut.

Voices of the Lost by Hoda Barakat, translated by Marilyn Booth (Oneworld)In a war-torn country, six characters share their secrets, in this international prize for Arabic fiction winner.

Childrens and teen

How to Change Everything by Naomi Klein with Rebecca Stefoff (Penguin)A guide to climate change billed as the young humans guide to protecting the planet and each other.

Nonfiction

Fall by John Preston (Viking)The author of A Very English Scandal turns his attention to the last days of disgraced media tycoon Robert Maxwell.

What Does Jeremy Think? by Suzanne Heywood (William Collins)A set of revealing insider political accounts, written up by the author after conversations with her husband, the former cabinet secretary Lord Heywood, who died of cancer aged 56 in 2018.

Consent: A Memoir by Vanessa Springora, translated by Natasha Lehrer (HarperCollins)The memoir, by the director of one of Frances leading publishing houses, of her sexual relationship as a teenager with a leading writer.

Bessie Smith by Jackie Kay (Faber)The national poet of Scotland has written a new introduction to her study of the American blues singer, whom she idolised as a young black girl growing up in Glasgow.

Keats by Lucasta Miller (Cape)A new biography in nine poems and an epitaph by the author of The Bront Myth, to coincide with the bicentenary of the poets death.

Brown Baby by Nikesh Shukla (Bluebird) A memoir from the Bristol-based editor of The Good Immigrant, which is also an exploration of how to raise a brown baby in an increasingly horrible world.

Karachi Vice by Samira Shackle (Granta) An impressive account of the inner workings of the Pakistani city, as exposed by the stories of five individuals.

The Code Breaker by Walter Isaacson (Simon & Schuster)The biographer of Leonardo da Vinci and Steve Jobs returns with a book about Crispr, the revolutionary tool that can edit DNA.

How to Avoid a Climate Disaster by Bill Gates (Allen Lane)The co-founder of Microsoft discusses the tools needed to reach net-zero greenhouse gas emissions.

Raceless by Georgina Lawton (Sphere)Reflections on identity along with recollections of growing up as a mixed-race girl raised by two white parents who pursued the untruth that the authors darker skin was the product of a so-called throwback gene.

Aftershocks by Nadia Owusu (Sceptre)A descendant of Ashanti royalty recounts growing up without a mother, travelling from country to country and feeling an absence of home her experience told through the metaphor of earthquakes.

19 Bicentenary of the birth of the explorer, linguist and author Richard Burton, who translated The One Thousand and One Nights and the Kama Sutra into English.

Fiction

Klara and the Sun by Kazuo Ishiguro (Faber)An Artificial Friend considers humanity and the meaning of love in Ishiguros first novel since winning the Nobel literature prize.

Double Blind by Edward St Aubyn (Harvill Secker)The author of the Patrick Melrose books investigates themes of inheritance, knowledge and freedom through the connections between three friends over one tumultuous year.

Transcendent Kingdom by Yaa Gyasi (Viking)This follow-up to her debut Homegoing, focusing on an immigrant Ghanaian family in the American South, has been a huge hit in the US.

Painting Time by Maylis de Kerangal, translated by Jessica Moore (MacLehose)The French author took the Wellcome science prize for her bravura novel about a heart transplant, Mend the Living; this new book is set in the world of trompe lil painting.

Hot Stew by Fiona Mozley (John Murray)Her debut Elmet made the Booker shortlist; this followup tackles money and class through the inhabitants of Londons Soho.

Kitchenly 434 by Alan Warner (White Rabbit)The Sopranos authors tale of a rock stars butler at the fag end of the 1970s promises to be Remains of the Day with cocaine and amplifiers.

The Committed by Viet Thanh Nguyen (Corsair)In the sequel to Pulitzer winner The Sympathizer, that novels conflicted spy finds himself in the underworld of 80s Paris.

The Absolute Book by Elizabeth Knox (Michael Joseph)From the New Zealand writer, a propulsive parallel-worlds fantasy epic about the power of stories and storytelling.

The Mysterious Correspondent by Marcel Proust, translated by Charlotte Mandell (Oneworld)Nine previously unseen stories illuminate a young writers development.

Names of the Women by Jeet Thayil (Cape)From Mary of Magdala to Susanna the Barren, women whose stories were suppressed in the New Testament.

Redder Days by Sue Rainsford (Doubleday)Twins in an abandoned commune prepare for apocalypse, in the follow-up to her standout debut Follow Me to Ground.

The Last House on Needless Street by Catriona Ward (Viper)A woman believes she has found the monster who snatched her younger sister as a child Full of twists and turns, this high-concept gothic horror is going to be huge.

Childrens and teen

The Wild Before by Piers Torday (Quercus)Can one hare change the world? A prequel to the Guardian prize-winning The Last Wild.

Poetry

Too Young, Too Loud, Too Different, edited by Maisie Lawrence and Rishi Dastidar (Corsair)An anthology celebrating 20 years of writers collective Malikas Poetry Kitchen, featuring work by now well-known alumni including Warsan Shire, Inua Ellams, Roger Robinson and Malika Booker herself.

Nonfiction

Beyond Order: 12 More Rules for Life by Jordan Peterson (Allen Lane)Having spent a year in rehab, the controversial Canadian psychologist, self-styled professor against political correctness follows up his global bestseller 12 Rules for Life.

Under a White Sky by Elizabeth Kolbert (Bodley Head)The Pulitzer prize-winning writer of The Sixth Extinction meets scientists and researchers and asks: can we change nature, this time to save it?

The Soul of a Woman: Rebel Girls, Impatient Love, and Long Life by Isabel Allende (Bloomsbury)An autobiographical meditation from the bestselling novelist on feminism and what women want.

New Yorkers by Craig Taylor (John Murray) The sequel to Taylors bestselling Londoners is another work of oral history, 10 years in the writing and drawing on hundreds of interviews.

The Diaries of Chips Channon, Volume 1: 1918-1938 edited by Simon Heffer (Hutchinson)The unexpurgated version of the often-quoted diaries of Henry Channon, social climber and Tory MP, who liked to gossip about politics and London society.

A Little Devil in America by Hanif Abdurraqib (Allen Lane)From Josephine Baker to Beyonc reflections on black performance from the author of a superb book on A Tribe Called Quest.

Inventory of a Life Mislaid by Marina Warner (William Collins)A memoir from the writer known for her books on feminism, myth and fairytales, which is structured around objects, from her mothers wedding ring to a 1952 film cylinder.

Friends by Robin Dunbar (Little, Brown)An exploration of friendship by the anthropologist and evolutionary psychologist known for the Dunbar Number, his theory that we can have meaningful relationships with only 150 people.

The Gun, the Ship and the Pen by Linda Colley (Profile) The historian best known for Britons retells modern history by considering the spread of written constitutions.

Failures of State by Jonathan Calvert and George Arbuthnot (Mudlark) Investigative journalists explore all the things the British government got wrong over Covid.

9 Bicentenary of the birth of the influential French poet, translator and critic Charles Baudelaire, author of Les Fleurs du Mal.

Fiction

Lean Fall Stand by Jon McGregor (4th Estate)An inquiry into the meaning of courage in the aftermath of a disastrous Antarctic research expedition, following the Costa-winning Reservoir 13.

My Phantoms by Gwendoline Riley (Granta)Fearless, darkly witty novel anatomising a toxic mother-daughter relationship.

Civilisations by Laurent Binet, translated by Sam Taylor (Harvill Secker)A counterfactual history of the modern world from the author of HHhH, examining the urge for power across time and space.

The High House by Jessie Greengrass (Swift)Sight was shortlisted for the Womens prize in 2018; in Greengrasss second novel, an ordinary family prepares for climate catastrophe.

This One Sky Day by Leone Ross (Faber)Set on a magical archipelago, a big, carnivalesque novel that takes on desire, addiction and postcolonialism, but is also a celebration of food, love and joy.

First Person Singular by Haruki Murakami, translated by Philip Gabriel (Harvill Secker)A new collection of eight stories that play with the boundary between memoir and fiction.

Hummingbird Salamander by Jeff VanderMeer (4th Estate)A climate change conspiracy thriller about ecoterrorism and extinction.

The Republic of False Truths by Alaa Al Aswany (Faber)A polyphonic novel about the 2011 Egyptian revolution.

Male Tears by Benjamin Myers (Bloomsbury)Farmers, boxers, ex-cons Short stories about men and masculinity.

Monsters by Barry Windsor-Smith (Cape)The US army runs a secret genetics programme in this epic graphic novel from the Marvel and Conan artist, 35 years in the making.

You Love Me by Caroline Kepnes (Simon & Schuster) The latest in the thriller series behind Netflix stalker blockbuster You.

Childrens and teen

Weirdo by Zadie Smith and Nick Laird, illustrated by Magenta Fox (Puffin)This first picture book from the husband and wife writers celebrates the quiet power of being different through the story of a guinea pig in a judo suit.

Bone Music by David Almond (Hodder)The Skellig authors new novel focuses on a young girl who moves from Newcastle to rural Northumberland and finds herself rewilded.

Poetry

A God at the Door by Tishani Doshi (Bloodaxe)The witty, wise and clear-eyed novelist, dancer and poet deploys both rage and sharp analysis covering issues from the precarious state of the environment to the treatment of women.

A Blood Condition by Kayo Chingonyi (Chatto & Windus)The second collection from the Dylan Thomas prize-winner explores both the personal and cultural influences of inheritance.

Nonfiction

Philip Roth: The Biography by Blake Bailey (Jonathan Cape)Renowned biographer Bailey was appointed by the American novelist, who died in 2018, and granted independence and complete access to the archive.

Go Big: How To Fix Our World by Ed Miliband (Bodley Head)Inspired by his Reasons to be Cheerful podcast, the shadow cabinet member investigates 20 transformative solutions to problems as intractable as inequality and the climate crisis.

How to Love Animals in a Human-Shaped World by Henry Mance (Jonathan Cape)Tapping into new thinking about animals and our changing perception of them, the FT journalist works in an abattoir, talks to chefs and philosophers and looks to a better future.

The rest is here:
2021 in books: what to look forward to this year - The Guardian

Recommendation and review posted by Bethany Smith

Dec. 28 (UPI) -- Fewer than 2% of people with treatment-resistant high blood pressure are checked for a hormone disorder that can drive blood pressure higher, a study published Monday by the Annals of Internal Medicine found.

In people with primary aldosteronism, the adrenal gland produces too much of a hormone called aldosterone, causing increases in blood pressure, often to unhealthy levels, according to the Mayo Clinic.

Professional guidelines recommend checking those with high blood pressure that doesn't respond to treatment for the hormonal disorder, but researchers found the tests often are not performed.

"While primary aldosteronism is a common cause of difficult to control hypertension, it is under-diagnosed," study co-author Dr. Jordana Cohen told UPI.

"Patients who were tested in our study were more likely to be treated with the appropriate medications ... and to have better blood pressure control over time, said Cohen, an assistant professor of medicine and epidemiology at the University of Pennsylvania.

Many people who don't respond well to commonly used blood pressure control medications, including beta blockers and ACE inhibitors, are found to have the hormone disorder, Cohen and her colleagues said.

The condition has been linked with a four- to 12-fold increased risk for cardiovascular events, such as heart attack and stroke, compared to those with high blood pressure due to other causes, the researchers said.

However, the disorder can be effectively treated with drugs called mineralocorticoid receptor antagonists, or MRAs, including spironolactone and eplerenone, or surgery, according to Cohen.

For this study, she and researchers at the University of Pennsylvania, Stanford University and the University of Michigan reviewed data from the Veterans Health Administration for more than 269,000 veterans with apparent treatment-resistant high blood pressure.

Treatment-resistant hypertension was defined as either two blood pressures of at least 140 systolic or 90 diastolic at least one month apart. Patients also had to be receiving treatment with at least three blood pressure drugs, including a diuretic, or with at least four different types of blood pressure drugs, the researchers said.

Just under 2% of patients with treatment-resistant high blood pressure underwent guideline-recommended testing for the hormone disorder, the data showed.

Testing rates ranged from 0% to 6% at centers included in the study and did not correlate with the number of patients with treatment-resistant hypertension, the researchers said.

And just 15% of the patients were on an MRA drug, the data showed.

Patients tested for the hormone condition were more likely to receive treatment with MRAs and have better long-term blood pressure control, according to the researchers.

Testing rates also did not change meaningfully over nearly two decades of follow-up despite an increasing number of guidelines recommending testing for the disorder in this population, they said.

"If you are on three or more medications for management of your blood pressure, ask your doctor if they think you might benefit from testing or from being treated with an MRA," Cohen said.

"Not all patients are appropriate to be tested or treated with MRAs, but most people with treatment resistant hypertension are," she said.

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Study: Too few with high blood pressure tested for hormone disorder - UPI News

Recommendation and review posted by Bethany Smith

After treating over 35,000 men, we understand their needs and we know what works.

GREENVILLE, S.C. (PRWEB) December 29, 2020

Greenville Mens Clinic, a local mens health company, has announced today an exciting merger & rebranding campaign that will better reflect its mission and dedication to mens health. The announcement of the new brand comes with a new patient-centric website that is solely focused on mens health from a global perspective.

With COVID-19 pushing many companies to the brink of closure, MHP and GMC saw an opportunity to meet mens health needs at the local and national level. By joining with Mens Health Partners, Greenville Mens Clinic is able to transition from a local mens health presence to one that is able to serve clients nationwide.

Our vision is to become a national leader in mens health, said Shauli Greenspan, CEO of Mens Health Partners, treating patients is what we do best, and this merger and rebranding allows us to address our patients needs more globally. This is not just cosmetic; weve taken this opportunity to evolve our service line and our treatment pathways to better address our clients needs.

Mens Health Partners is changing the way mens health is done in Greenville, South Carolina. They offer affordable, custom treatments to resolve Erectile Dysfunction & Peyronies. MHP also provides weight loss, solutions for hormone deficiencies, and provides STD testing.

We have always offered a discreet and confidential approach to our clients, said Ty Hopkins, COO of Mens Health Partners, after treating over 35,000 men, we understand their needs and we know what works. A vast majority of our clients have tried online pills to remedy a pretty complex disease, these pills often fail with time. We have achieved a 95% success rate with our clients, and we want to close that gap even more.

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The Men's Health Partners and Greenville Men's Clinic Merger Changes the Way Men's Healthcare is done in South Carolina - PR Web

Recommendation and review posted by Bethany Smith

Before this year, I thought that you could be either pregnant or not pregnant. As it happens, its not always that simple. Last August, two weeks after an embryo was transferred to my uterus in the basement of a Harley Street fertility clinic, I held a pregnancy test up to the strong sunlight at my bedroom window. The control line, which indicated whether or not the test was working, was clear and dark pink. The test line, which indicated whether or not I was pregnant, was faint, like a shadow. In some light it was impossible to discern in some light but standing at the window, there it was: hope.

The embryo had been in a freezer for the best part of the year before it was transferred. It had been created using my egg and my husbands sperm at our local hospital in east London because, due to illness, conceiving naturally was no longer possible for us. We had commenced treatment after almost a year on an NHS waiting list: I injected myself with hormones and doctors retrieved eggs from my ovaries; they were injected with my husbands sperm and became embryos. Due to a complication, it wasnt safe for them to be transferred straight away so they were frozen. On New Years Eve 2019, we toasted our three frozen embryos as we looked ahead to 2020: this would be the year I became pregnant, this would be a good year.

In February 2020, the first of the frozen embryos was transferred. My husband was there with me, holding my hand, as the doctor placed it in my uterus. She reeled off instructions afterwards: no sex for seven days, no alcohol, no smoking, do an at-home pregnancy test in 13 days.

The test was negative; the transfer had failed. And in those 13 days, the world had changed. It was clear that coronavirus had spread to Europe. Soon, Downing Street announced that the virus was likely to spread in the UK in a significant way. The fertility clinic we were being treated at closed shortly afterwards; staff were deployed to other parts of the hospital as the NHS buckled under the strain of the pandemic. At the end of March, all fertility treatment in NHS and private clinics was cancelled. IVF became just another part of life that would not happen now: no parties, no theatre, no babies that feel like miracles, no leaving the country, no hugs.

To live with infertility and to undergo fertility treatment is to live with constant uncertainty. Often, it is unclear why pregnancy doesnt occur in the first place: unexplained infertility is a common diagnosis. As a patient, you offer yourself up in the quest for certainty. You are probed, an ultrasound wand inserted into your body, manoeuvred inside you, as a sonographer counts the little sacs in your ovaries. Blood is drawn and hormone levels are measured. Still, no one can say what you want to hear, no one can say that you will definitely have a baby.

By the summer, fertility clinics were authorised to resume treatment but our clinic remained shut: I dont know when it will reopen, a receptionist told me when I called the hospital switchboard. My husband and I arranged to have both the remaining embryos transferred to a private clinic, at a cost of thousands. I imagined myself with twins, what a handful they would be. On the day of the transfer, the embryologist told me that one of the frozen embryos hadnt survived the thaw.

Isnt that rare? I asked.

Its uncommon but not rare, he said. It happens.

The last embryo of the three transferred in clinic basement as my husband waited on the street because Covid regulations meant he couldnt come inside was the one that created that shadow line on a pregnancy test back in August. It nearly made it. It was a sort-of pregnancy; an almost pregnancy; what is known, officially, as a chemical pregnancy or early miscarriage. By then we knew 2019s three embryos werent going to become our future children.

We moved to Ireland, where I am from, and started a new cycle, at a new clinic. All was going well with the process until it wasnt. There will be so many eggs, I was told by a doctor on a Monday. Then, on a Wednesday, I was told that, actually, there will be very few eggs.

It is now the end of the year and the uncertainty is ongoing. I live alongside the unknowing. And after so much uncertainty, I find that I can just about tolerate it. I got good practice this year, we all did this was the year that certainty evaporated, the word plan became more or less meaningless. And without the sturdy reliability of a plan, I had to turn to gratitude instead. Before this year, I thought it was cheesy to be thankful for things that are common or easily won, but when you witness the unravelling of the way life has always been, when you look on as industries and livelihoods are destroyed, when you know families who have been bereaved suddenly, that changes how you see things. Amid so much loss, it becomes clear that you are lucky and it becomes easier to feel grateful.

I still feel anger, despair and, sometimes when I see somebody elses huge bump, a terrible envy. I still use Google to search for answers to weirdly specific queries, hoping that somebody, somewhere, on some fertility forum, will tell me that it will all work out. I still long for certainty but, in the absence of it, I get by on hope and gratitude.

When the weather forecast predicts rain, but they were wrong and it stays dry, that is something to be grateful about. When the heron might not be there, but then he is, standing proud by the riverbank as you walk home from the IVF clinic, that is something to be grateful about. When it doesnt work this time, but there is always next time, that is something to be grateful about.

Lynn Enright is a journalist and the author of Vagina: A Re-education

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My fertility treatment failed three times in 2020 and I discovered how to live with uncertainty - The Guardian

Recommendation and review posted by Bethany Smith

Breakfast may be the "most important meal of the day," but lunch is certainly a huge deal as well. A good, healthy lunch can help keep your energy levels high and prevent you from mindless mid-afternoon snacking later. But what would be considered the healthiest lunches to have? We reached out to a few registered dietitians and asked them their recommendations for the healthiest lunches you can possibly have.

Here are the meals they say are the best-of-the-best, and for more healthy tips, be sure to check out our list of the 100 Easiest Recipes You Can Make.

"One of the healthiest lunches you can have is grilled salmon over a colorful salad," says Lisa Young, PhD, RDN, and author of Finally Full, Finally Slim. "Salmon is high in protein which helps you to feel full and rich in heart-healthy omega 3 fatty acids (known as "good fats"). A colorful salad contains an assortment of veggies, which are high in antioxidants, vitamins, and minerals and the different colors ensure that you are getting a mix of different nutrients. I love a blend of romaine lettuce, spinach, carrots, tomatoes, red peppers, and cucumbers."

Or try ourHoney-Mustard Glazed Salmon With Roasted Asparagus Recipe.

"Did you know that seafood is one of the best dietary sources of animal protein? It's packed with vital nutrients, such as heart-healthy omega-3s, and has less saturated fat and cholesterol than other protein options," says Rima Kleiner MS, RD, a Registered and Licensed Dietitian and Nutritionist at Dish on Fish. "Protein may help our brains recognize the hormone leptin, which helps us feel fuller longer and provides energy for our bodies."

An easy way to get seafood into your lunch routine is prepping a tuna melt! This healthy tuna and veggie melt is a filling lunch that's still low in calories but packed with nutrients.

"I love putting veggies and grain bowl together because you can use up what you've got in the fridge and create endless variations," says Frances Largeman-Roth, RDN. "I like starting with a base of high fiber barley or quinoa and adding whatever colorful veggies I have on hand. This time of year it's probably roasted Brussels sprouts and carrots, plus a bit of kimchee for probiotics and then a packet of tuna for high-quality protein. I like the ones from Bumble Bee because they come in tasty flavors like Thai Chili, they require no prep, and they offer important vitamins and minerals, like vitamin D (so important for winter!), iron, and selenium."

Here'sHow to Make a Delicious Buddha Bowl for Weight Loss.

"I am a huge fan of packing my lunch like you would your kid's for school," says Amy Goodson, MS, RD, CSSD, LD, and author of The Sports Nutrition Playbook. "One of my go-to's is the 'Adult Lunchable' that includes cheese, whole grain crackers, grapes, turkey, veggie like mini sweet peppers, baby carrots or cherry tomatoes, and some nuts. With fiber, protein, and healthy fat, you will get full faster and stay full longer, plus get tons of nutrients!"

"So many people get protein and veggies on their salad, but then find themselves sluggish mid-afternoon because they did not get carbohydrates at lunch," says Goodson. "The ultimate salad is one with all the food groups. As a dietitian, one of my favorites is a pan-seared salmon salad with mixed greens, goat cheese, berries, pecans, and a grain like quinoa or farro. The best part of the 5-Food Group salad lunch is that you can mix and match your proteins, cheese, nuts, fruit, and grains to make all kinds of combinations to keep it interesting and flavorful. Including all five food groups will help you feel more satisfied and less likely to go grazing on snack foods a few hours later."

Or try our Warm-Kale Quinoa Salad, which includes all of the food groups Goodson recommends!

"Soup and salad lunches offer an opportunity to get lots of healthy foods such as veggies, beans, lentils, nuts, and seeds," says MyNetDiary's Registered Dietitian and MS, Brenda Braslow. "These plant-based meals offer loads of protein, vitamins, minerals, antioxidants, and fiber to keep our bodies healthy and immune systems strong."

Try our Veggie-Packed Minestrone Pesto Soup with a simple green salad for lunch!

"A quick and easy lunch I rely on quite a bit is what I call [the] Egg Scramble Whole Wheat Tortilla Wrap," says Cheryl Mussatto MS, RD, LD of Eat Well To Be Well RD. "Scramble two eggs with black beans along with diced cherry tomatoes and diced avocado. When cooked, place in the whole wheat wrap with a sprinkle of pepper jack cheese topped with fresh salsa and you're done. Protein-packed, fiber-filled, rich in monounsaturated fat, and simply delicious, this keeps me satiated for hours until dinner. I'll also include a side of fruit such as a few apple slices, grapes, or a small pear for a more well-balanced meal and for extra fiber."

Try our version with this Fiber-Filled Breakfast Burrito recipe!

"Lunch is an important meal of the day. You want to go for, not only what keeps you full, but also what gives you the energy to go about the next five or so hours of school, work, or any other day's activity," says Edie Reads, RD and chief editor at healthadvise.org. "You also want to avoid [processed] carbs. These are unhealthy, will easily lead to weight gain and digestive issues such as constipation, diarrhea, and bloating."

Reads says salads, in particular, are a great choice for lunch.

"Make yours with lots of proteins, and greens," says Reads. "If you want, you can top it up with some dressing. Try out the Mediterranean-style salad."

This Greek Salad Recipe is a great place to start!

"Some vegetable curry will also do," says Reads. "it comes packed with lots of vitamins and antioxidants. You'll also feel full for longer and may not need to snack."

Try our version with this Cauliflower and Butternut Squash Curry Stir Fry!

Rachel Paul, PhD, RD, CDN, recommends making a stuffed avocado salad for an easy, filling, low-carb lunch idea.

"[To make], slice an avocado in half and take out the pit," says Paul. "Mix a can of tuna with 1/4 cup diced grape tomatoes. Add the tuna to the avocado halves and sprinkle with everything but the bagel seasoning. Have 1 to 2 cups of baby carrots on the side. This meal is full of protein, fat, and high fiber veggies, making it very fillingit will keep you full for hours."

Or try our version with this Light Avocado Crab Salad!

Breakfast sandwiches make for great lunch sandwiches, too!

"It consists of carbohydrates, protein, and sodium that are healthy and also can help in weight loss," says Shannon Henry, RD for EZCare Clinic.

To make this particular sandwich, cook up two eggs. Spread a little bit of butter on your bread and add a slice of Swiss cheese, fried egg, avocado, cheddar cheese, and the remaining bread slice. Grill on the stove for a few minutes on each side until golden brown!

For more lunch ideas, try one of these 73+ Best Healthy Lunch Recipes.

Read more from the original source:
The 11 Healthiest Lunches to Have, According to Dietitians | Eat This Not That - Eat This, Not That

Recommendation and review posted by Bethany Smith

Here's a little history lesson: Pepsi, Coca Cola, and Dr. Pepperthe oldest sodas in the worldwere all invented by pharmacists. In fact, these soft drinks were originally intended to serve as remedies for nausea, headaches, heartburn, and other ailments. Considering the fact that the most common ingredients found in soda these days include high fructose corn syrup, artificial flavorings, and food colorings, and phosphoric acidall of which can have negative health effects when consumed in excessthat's pretty surprising. While the occasional can of soda may not have dangerous implications, doctors say drinking it even semi-regularly is one of the dangerous soda habits you can get into from a health standpoint.

"There's a risk to develop oral cavity problems, kidney malfunction, decreased blood flow to the brain, heart disease, osteoporosis, and ulcers, among many other diseases that can be exacerbated by a soda addiction," says Dr. Ava Williams, a board-certified Primary Care doctor at Doctor Spring. "You may not know it, but each can you drink already brings you a step closer to any of those illnesses."

One of the reasons why soda is considered so unhealthy is that it contains virtually no nutrientsmeaning it's basically just empty calories. Not to mention, the typical can of soda contains about 7 to 10 teaspoons of sugar. According to Harvard Health, if you were to drink just one serving of soda a day and not cut back on calories in other areas of your diet, you could gain 5 pounds a year. In part, this is because your liver turns fructose (sugar) into fat when you consume too much of it.

But beyond potentially gaining weight, research has repeatedly proven that these syrupy sweet beverages can also increase your risk of many chronic diseases, including type 2 diabetes, metabolic syndrome, and gout. One study even found that a higher soft drink intake was associated with an increased risk of death from any causeregardless of whether it contained sugar or artificial sweetener.

In case you need a little more motivation to nix soft drinks from your diet once and for all, here are how some of the most dangerous soda habits could impact your health. And for more healthy tips, be sure to check out our list of 15 Underrated Weight Loss Tips That Actually Work.

You may want to think twice before guzzling down a soda on the daily.

"The high amount of sugars (fructose) that are present in sodas can make you gain weight without fulfilling your hunger," says Dr. Amber O'Brien, MD, a health expert for Mango Clinic.

The average can of soda contains It's not just the excess sugar and calories in soda itself that poses an issue when it comes to weight gain. There have been dozens of studies that have explored the link between soft drink consumption and weight, and the consistent finding is that the more soda you drink, the more likely you are to consume more calories from other sources as well.

"It can also lead to vitamin or mineral deficiencies, as you are no longer hungry after drinking these empty calories," says Dr. Leann Poston MD, a licensed physician with Invigor Medical.

That's not all. Dr. Poston and Dr. O'Brien both note that sugary beverages like soda can also cause insulin resistance.

"Insulin is a hormone that ushers sugar into body cells," explains Dr. Poston. "If cells are resistant to the effects of insulin, glucose (sugar) increases in the blood and leads to Type 2 diabetes. Weight gain from soda consumption can also lead to insulin resistance, which can ultimately lead to type 2 diabetes."

Here are the 28 Unhealthiest Sodas That Are Never Worth Drinking.

Soda contains certain acidsincluding phosphoric acid and carbonic acidwhich can make your teeth more vulnerable to decay.

"If your tooth enamel is weak, you should avoid consuming sodas as they can cause cavities and tooth enamel destruction," says Dr. O'Brien.

Dr. Poston adds that the sugar in soda can lead to a plaque buildup on your teeth by feeding the bacteria in your mouth.

"Soda is highly acidic and therefore can increase the risk of cavities and gum disease," she says.

Basically, regularly drinking soda could ultimately lead to more dentist office visits.

Dr. Williams also points out that the phosphoric acid content can raise your risk of developing osteoporosis because when it gets digested in your stomach, it binds to calcium and therefore prevents your body from absorbing it for bone strength.

Here are 12 Foods and Drinks to Avoid If You Have Sensitive Teeth.

When those afternoon hungerpangs hit at the office, experts say one of the worst things you can do is grab a soda from the vending machine. In fact, while the bubbles may make you feel a temporary sense of fullness, soda could also cause an upset stomach if you haven't eaten anything recently.

"It's most dangerous to drink soda on an empty stomach because when your stomach receives something for digestion, it releases acid," says Dr. Williams. "When you drink soda, an acidic drink, you're just releasing extra acid into your stomach. It disrupts the acid-alkaline balance in your stomach and linings of your gastrointestinal system, causing you to feel tummy aches and pains."

Instead, sip on one of these 12 Healthiest Teas on Grocery Store Shelves.

Think diet soda is healthier for you? Think again. Just because these alternatives are calorie- and sugar-free doesn't mean they don't come with their own risks.

"Diet sodas contain more chemicals than regular sodas," says Dr. Poston. "These chemicals can adversely affect gut bacteria and insulin sensitivity. There are even some scientific studies that show that artificial sweeteners can cause insulin resistance and weight gain, just like sugar, but the jury is still out on this."

Not only that, but Dr. Williams adds that diet soda is just as addicting as regular soda, and contains nearly all of the same questionable ingredients with the exception of the type of sweetenermeaning it comes with many of the same negative health implications. In fact, research has found that consuming high amounts of diet soda and artificial sweeteners is associated with an increased risk of obesityand metabolic syndrome. Additionally, studies have linked diet soda to an increase in the risk of stroke, kidney disease, osteoporosis, tooth decay, high blood pressure, type 2 diabetes, and even depression.

It's no secret that consuming caffeine can make it more difficult for you to fall asleep. Once it enters the bloodstream, it causes your body to ramp up adrenaline production while increasing your blood pressure and simultaneously blocking the chemicals in your brain that allow you to feel sleepy. That's why Dr. Williams strongly advises against drinking sodas that contain caffeine late in the day.

Even in moderate doses, it can cause insomnia, headaches, nervousness, anxiety, irritability, sleep disturbances, rapid heartbeat, and excessive urination.

It's also worth mentioning that caffeine can have diuretic propertiesby causing you to urinate more frequently, it may put you at a higher risk for dehydration.

Insufficient sleep is associated with a whole slew of health concerns, and since drinking soda at night or even in the late afternoon can inhibit your ability to sleep at night, that's one habit that's best to ditch.

Ready to give up soda for good? Here are 6 Surprising Reasons to Finally Give Up Soda.

Excerpt from:
The Most Dangerous Soda Habits You Need to Kick, Say Doctors - Eat This, Not That

Recommendation and review posted by Bethany Smith

Blurred vision

Blurred vision is one of the earliest warning signs of diabetes, warned Specsavers clinical spokesman, Dr Nigel Best.

Those most at risk are people whose vision swaps between blurry and perfectly normal.

Its caused by blood sugar levels being unstable, Best exclusively toldExpress.co.uk.

Fluctuating blurred vision is the main symptom people with diabetes get in their eyes, he said.

People may find that one day they have blurred vision but another day they can see perfectly fine, this is down to their sugar levels not being stable.

Blurred vision is also a warning sign of diabetic retinopathy, a complication caused by damage to the blood vessels at the back of the eye.

Diabetes patients are more at risk of developing blurred vision and changes to the eyes, according to Ophthalmic Consultants of London's retinal surgeon, Mr Shahram Kashani.

When the condition is advanced, it can cause abnormal blood vessels to develop at the back of the eye.

These can lead to a number of complications, including floaters.

Floaters are dark spots in your vision that may appear as black or grey specks or strings.

See more here:
Type 2 diabetes: Blurred vision and floaters in the eyes are signs of high blood sugar - Express

Recommendation and review posted by Bethany Smith

I've been dealing with acne for so long that oftentimes, I forget what my clear, baby-faced skin once looked like back in middle school. If you, too, have been dealing with acne for most of your adult life (according to the American Academy of Dermatology, acne occurring in adults is steadily increasing), you've probably tried every over-the-counter (OTC) and prescription treatment available in an attempt to keep your breakouts at bay.

As you probably already know, benzoyl peroxide and salicylic acid are the two most widely used ingredients within the dermatology field, and have been proven to kill acne-forming bacteria underneath the skin. The vast majority of skin-care products feature these two powerhouses within their acne-focused formulas, and while they do work for some folks, they arent the cure-all for everyone.

No, the list of ingredients below are not all necessarily new to the dermatology world, but they are all new developments in recent acne-fighting formulas many scientists and dermatologists are just now discovering the potential efficacy that these ingredients can have in treating and minimizing breakouts, without the added irritation that comes along with ingredients like salicylic acid and benzoyl peroxide. If these powerhouse ingredients aren't working for you, it might be time to try something new.

Whether it's adding probiotics, thyme and oregano, monk's pepper, honey, or clascoterone to your skin-care regimen, read on to discover the multiple alternatives research has suggested have the potential to also fight against acne, each in their own unique way.

The connection between your gut health and skin health only seems to be growing, and many probiotic-focused skin-care brands, including Aurelia Skincare and Ellis Day Skin Science, are developing products to create balance outside the gut microbiome, onto the skin microbiome.

"An imbalance of bacteria in the gut can lead to leaky gut, but an imbalance of bacteria on the skin can lead to something I call 'leaky skin,'" explains Whitney Bowe, a board-certified dermatologist in the greater New York City area and author of the book The Beauty of Dirty Skin. "When your skin microbiome is off-balance, meaning that the healthy balance of good bacteria on your skin is not intact, this can compromise your skin's natural barrier. This leads to inflammation, which, in turn, results in chronic skin conditions like acne, eczema, rosacea, and psoriasis."

An unhealthy skin microbiome can not only trigger chronic, ongoing inflammation in the skin, but it can also allow unhealthy, inflammatory microbes to take hold and thrive. "Specifically, in the case of acne, microbial balance on the skin is critical because it helps prevent inflammation, helps maintain a healthy skin barrier (which is so important in preventing acne), and it keeps inflammatory microbes like P. acnes from overgrowing and exacerbating papules and pustules in the skin," explains Bowe.

Read the original here:
7 New Acne-Treating Ingredients Alternative Acne Treatments - Allure Magazine

Recommendation and review posted by Bethany Smith

This week we experienced the shortest day of the year well if youre a cup half-empty type of person. Or, if you tend to be more positive (something I strive to be), it was the longest night of the year! Stating the obvious, that we are not seeing the sun as much, is clearly that, stating the obvious. It is no wonder people start feeling lethargic, moody and stuck in a rut.

Nothing says, lets get energized and have a productive day like heading in to work when it is pitch black outside, your car needs to be plugged in and you are buried in winter gear.

MORE FROM KRISTEN ASLESON:

For as many as one out of five people, winter means much more than having to deal with unruly hair and dry skin. Those people suffer from a disorder called Seasonal Affective Disorder, or SAD. According to the American Psychiatric Association, 75 percent of those people are women.

SAD is a type of depression that occurs every year at the same time. Most peoples symptoms begin in the early fall and continue throughout the winter months. And for most, once the sunnier days of spring and summer break through, the symptoms disappear.

SAD begins to appear in myriad of ways, including:

Depression.

Hopelessness.

Anxiety.

Heavy, leaden feeling in the arms or legs.

Social withdrawal.

Oversleeping.

Loss of interest in activities you once enjoyed.

Appetite changes, especially craving foods high in carbohydrates

Weight gain.

Difficulty concentrating.

I am sure reading this list of is causing a lot of readers to evaluate their feelings. Keep in mind it is normal to have some days when you are feeling more down than others. Even the happiest of people struggle to keep their attitudes on the perky side during the dreary days of winter. But, if you feel down for long stretches at a time, and the activities that normally you enjoy cant seem to get you motivated, then maybe it is time to see a doctor.

According to Mayo Clinic, the specific cause of SAD is unknown. However, as with many mental health conditions, genetics, age and your bodys chemical makeup all play a role in the development of this condition.

There are a few specific factors to attribute to the development of this condition. For instance, the reduced level of sunlight in fall and winter may disrupt your bodys internal clock, leading to feelings of depression.

Feelings of depression can also be caused by a drop in levels of serotonin. Serotonin is a brain chemical that affects ones mood, and it may have a role in seasonal affective disorder.

Lastly, the changes in the season can disrupt the balance of the natural hormone melatonin. This disruption in balance can interrupt sleep patterns and cause moodiness.

If you are having severe symptoms, you may need medications, light therapy or other treatments. However, here are some ideas that will help you battle those down in the dumps days better.

Make your environment sunnier and brighter by opening blinds, trimming tree branches that block sunlight or adding skylights to your home. Sit closer to bright windows while at work or home.

As cold as it is, get outside, even if only for a few seconds at a time. The best time to do this is within two hours of getting up.

Regular exercise! Getting physical helps relieve stress and anxiety. Being more fit can make you feel better about yourself, which also helps lift your mood.

If you suffer from SAD, you are not alone. There are thousands of people who experience the winter blues and blahs. If you are one who experiences more serious symptoms, seek help. The good news is that there are ways to cope and other plans that can help you get through the winter months.

Kristen Asleson is owner of Midwest Virtual Assistants. Send comments and ideas to news@postbulletin.com.

See the article here:
Winter got you down? It could be Seasonal Affective Disorder - PostBulletin.com

Recommendation and review posted by Bethany Smith

The report titled Global Thyroid Stimulating Hormone Test Kit Market is one of the most comprehensive and important additions to QY Researchs archive of market research studies. It offers detailed research and analysis of key aspects of the global Thyroid Stimulating Hormone Test Kit market. The market analysts authoring this report have provided in-depth information on leading growth drivers, restraints, challenges, trends, and opportunities to offer a complete analysis of the global Thyroid Stimulating Hormone Test Kit market. Market participants can use the analysis on market dynamics to plan effective growth strategies and prepare for future challenges beforehand. Each trend of the global Thyroid Stimulating Hormone Test Kit market is carefully analyzed and researched about by the market analysts.The market analysts and researchers have done extensive analysis of the global Thyroid Stimulating Hormone Test Kit market with the help of research methodologies such as PESTLE and Porters Five Forces analysis. They have provided accurate and reliable market data and useful recommendations with an aim to help the players gain an insight into the overall present and future market scenario. The Thyroid Stimulating Hormone Test Kit report comprises in-depth study of the potential segments including product type, application, and end user and their contribution to the overall market size.

Get PDF Sample Copy of Report: (Including TOC, List of Tables & Figures, Chart) https://www.qyresearch.com/sample-form/form/2356370/global-thyroid-stimulating-hormone-test-kit-market

In addition, market revenues based on region and country are provided in the Thyroid Stimulating Hormone Test Kit report. The authors of the report have also shed light on the common business tactics adopted by players. The leading players of the global Thyroid Stimulating Hormone Test Kit market and their complete profiles are included in the report. Besides that, investment opportunities, recommendations, and trends that are trending at present in the global Thyroid Stimulating Hormone Test Kit market are mapped by the report. With the help of this report, the key players of the global Thyroid Stimulating Hormone Test Kit market will be able to make sound decisions and plan their strategies accordingly to stay ahead of the curve.

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Key Players Mentioned: Innodx, Bioscience, Daan, Ying Sheng Biology, Easydiagnosis, Tellgen, Bioscience, BGI, Chivd

Market Segmentation by Product: Time-resolved ImmunofluorescenceChemiluminescence Immunoassay

Market Segmentation by Application: HospitalClinic

The Thyroid Stimulating Hormone Test Kit Market report has been segregated based on distinct categories, such as product type, application, end user, and region. Each and every segment is evaluated on the basis of CAGR, share, and growth potential. In the regional analysis, the report highlights the prospective region, which is estimated to generate opportunities in the global Thyroid Stimulating Hormone Test Kit market in the forthcoming years. This segmental analysis will surely turn out to be a useful tool for the readers, stakeholders, and market participants to get a complete picture of the global Thyroid Stimulating Hormone Test Kit market and its potential to grow in the years to come.

Key questions answered in the report:

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Table of Contents:

1 Thyroid Stimulating Hormone Test Kit Market Overview1.1 Thyroid Stimulating Hormone Test Kit Product Overview1.2 Thyroid Stimulating Hormone Test Kit Market Segment by Type1.2.1 Time-resolved Immunofluorescence1.2.2 Chemiluminescence Immunoassay1.3 Global Thyroid Stimulating Hormone Test Kit Market Size by Type (2015-2026)1.3.1 Global Thyroid Stimulating Hormone Test Kit Market Size Overview by Type (2015-2026)1.3.2 Global Thyroid Stimulating Hormone Test Kit Historic Market Size Review by Type (2015-2020)1.3.2.1 Global Thyroid Stimulating Hormone Test Kit Sales Market Share Breakdown by Type (2015-2020)1.3.2.2 Global Thyroid Stimulating Hormone Test Kit Revenue Market Share Breakdown by Type (2015-2020)1.3.2.3 Global Thyroid Stimulating Hormone Test Kit Average Selling Price (ASP) by Type (2015-2020)1.3.3 Global Thyroid Stimulating Hormone Test Kit Market Size Forecast by Type (2021-2026)1.3.3.1 Global Thyroid Stimulating Hormone Test Kit Sales Market Share Breakdown by Type (2021-2026)1.3.3.2 Global Thyroid Stimulating Hormone Test Kit Revenue Market Share Breakdown by Type (2021-2026)1.3.3.3 Global Thyroid Stimulating Hormone Test Kit Average Selling Price (ASP) by Type (2021-2026)1.4 Key Regions Market Size Segment by Type (2015-2020)1.4.1 North America Thyroid Stimulating Hormone Test Kit Sales Breakdown by Type (2015-2020)1.4.2 Europe Thyroid Stimulating Hormone Test Kit Sales Breakdown by Type (2015-2020)1.4.3 Asia-Pacific Thyroid Stimulating Hormone Test Kit Sales Breakdown by Type (2015-2020)1.4.4 Latin America Thyroid Stimulating Hormone Test Kit Sales Breakdown by Type (2015-2020)1.4.5 Middle East and Africa Thyroid Stimulating Hormone Test Kit Sales Breakdown by Type (2015-2020)

2 Global Thyroid Stimulating Hormone Test Kit Market Competition by Company2.1 Global Top Players by Thyroid Stimulating Hormone Test Kit Sales (2015-2020)2.2 Global Top Players by Thyroid Stimulating Hormone Test Kit Revenue (2015-2020)2.3 Global Top Players Thyroid Stimulating Hormone Test Kit Average Selling Price (ASP) (2015-2020)2.4 Global Top Manufacturers Thyroid Stimulating Hormone Test Kit Manufacturing Base Distribution, Sales Area, Product Type2.5 Thyroid Stimulating Hormone Test Kit Market Competitive Situation and Trends2.5.1 Thyroid Stimulating Hormone Test Kit Market Concentration Rate (2015-2020)2.5.2 Global 5 and 10 Largest Manufacturers by Thyroid Stimulating Hormone Test Kit Sales and Revenue in 20192.6 Global Top Manufacturers by Company Type (Tier 1, Tier 2 and Tier 3) (based on the Revenue in Thyroid Stimulating Hormone Test Kit as of 2019)2.7 Date of Key Manufacturers Enter into Thyroid Stimulating Hormone Test Kit Market2.8 Key Manufacturers Thyroid Stimulating Hormone Test Kit Product Offered2.9 Mergers & Acquisitions, Expansion

3 Global Thyroid Stimulating Hormone Test Kit by Region (2015-2026)3.1 Global Thyroid Stimulating Hormone Test Kit Market Size and CAGR by Region: 2015 VS 2020 VS 20263.2 Global Thyroid Stimulating Hormone Test Kit Market Size Market Share by Region (2015-2020)3.2.1 Global Thyroid Stimulating Hormone Test Kit Sales Market Share by Region (2015-2020)3.2.2 Global Thyroid Stimulating Hormone Test Kit Revenue Market Share by Region (2015-2020)3.2.3 Global Thyroid Stimulating Hormone Test Kit Sales, Revenue, Price and Gross Margin (2015-2020)3.3 Global Thyroid Stimulating Hormone Test Kit Market Size Market Share by Region (2021-2026)3.3.1 Global Thyroid Stimulating Hormone Test Kit Sales Market Share by Region (2021-2026)3.3.2 Global Thyroid Stimulating Hormone Test Kit Revenue Market Share by Region (2021-2026)3.3.3 Global Thyroid Stimulating Hormone Test Kit Sales, Revenue, Price and Gross Margin (2021-2026)

4 Global Thyroid Stimulating Hormone Test Kit by Application4.1 Thyroid Stimulating Hormone Test Kit Segment by Application4.1.1 Hospital4.1.2 Clinic4.2 Global Thyroid Stimulating Hormone Test Kit Sales by Application: 2015 VS 2020 VS 20264.3 Global Thyroid Stimulating Hormone Test Kit Historic Sales by Application (2015-2020)4.4 Global Thyroid Stimulating Hormone Test Kit Forecasted Sales by Application (2021-2026)4.5 Key Regions Thyroid Stimulating Hormone Test Kit Market Size by Application4.5.1 North America Thyroid Stimulating Hormone Test Kit by Application4.5.2 Europe Thyroid Stimulating Hormone Test Kit by Application4.5.3 Asia-Pacific Thyroid Stimulating Hormone Test Kit by Application4.5.4 Latin America Thyroid Stimulating Hormone Test Kit by Application4.5.5 Middle East and Africa Thyroid Stimulating Hormone Test Kit by Application5 North America Thyroid Stimulating Hormone Test Kit Market Size by Country (2015-2026)5.1 North America Market Size Market Share by Country (2015-2020)5.1.1 North America Thyroid Stimulating Hormone Test Kit Sales Market Share by Country (2015-2020)5.1.2 North America Thyroid Stimulating Hormone Test Kit Revenue Market Share by Country (2015-2020)5.2 North America Market Size Market Share by Country (2021-2026)5.2.1 North America Thyroid Stimulating Hormone Test Kit Sales Market Share by Country (2021-2026)5.2.2 North America Thyroid Stimulating Hormone Test Kit Revenue Market Share by Country (2021-2026)6 Europe Thyroid Stimulating Hormone Test Kit Market Size by Country (2015-2026)6.1 Europe Market Size Market Share by Country (2015-2020)6.1.1 Europe Thyroid Stimulating Hormone Test Kit Sales Market Share by Country (2015-2020)6.1.2 Europe Thyroid Stimulating Hormone Test Kit Revenue Market Share by Country (2015-2020)6.2 Europe Market Size Market Share by Country (2021-2026)6.2.1 Europe Thyroid Stimulating Hormone Test Kit Sales Market Share by Country (2021-2026)6.2.2 Europe Thyroid Stimulating Hormone Test Kit Revenue Market Share by Country (2021-2026)7 Asia-Pacific Thyroid Stimulating Hormone Test Kit Market Size by Region (2015-2026)7.1 Asia-Pacific Market Size Market Share by Region (2015-2020)7.1.1 Asia-Pacific Thyroid Stimulating Hormone Test Kit Sales Market Share by Region (2015-2020)7.1.2 Asia-Pacific Thyroid Stimulating Hormone Test Kit Revenue Market Share by Region (2015-2020)7.2 Asia-Pacific Market Size Market Share by Region (2021-2026)7.2.1 Asia-Pacific Thyroid Stimulating Hormone Test Kit Sales Market Share by Region (2021-2026)7.2.2 Asia-Pacific Thyroid Stimulating Hormone Test Kit Revenue Market Share by Region (2021-2026)8 Latin America Thyroid Stimulating Hormone Test Kit Market Size by Country (2015-2026)8.1 Latin America Market Size Market Share by Country (2015-2020)8.1.1 Latin America Thyroid Stimulating Hormone Test Kit Sales Market Share by Country (2015-2020)8.1.2 Latin America Thyroid Stimulating Hormone Test Kit Revenue Market Share by Country (2015-2020)8.2 Latin America Market Size Market Share by Country (2021-2026)8.2.1 Latin America Thyroid Stimulating Hormone Test Kit Sales Market Share by Country (2021-2026)8.2.2 Latin America Thyroid Stimulating Hormone Test Kit Revenue Market Share by Country (2021-2026)9 Middle East and Africa Thyroid Stimulating Hormone Test Kit Market Size by Country (2015-2026)9.1 Middle East and Africa Market Size Market Share by Country (2015-2020)9.1.1 Middle East and Africa Thyroid Stimulating Hormone Test Kit Sales Market Share by Country (2015-2020)9.1.2 Middle East and Africa Thyroid Stimulating Hormone Test Kit Revenue Market Share by Country (2015-2020)9.2 Middle East and Africa Market Size Market Share by Country (2021-2026)9.2.1 Middle East and Africa Thyroid Stimulating Hormone Test Kit Sales Market Share by Country (2021-2026)9.2.2 Middle East and Africa Thyroid Stimulating Hormone Test Kit Revenue Market Share by Country (2021-2026)

10 Company Profiles and Key Figures in Thyroid Stimulating Hormone Test Kit Business10.1 Innodx10.1.1 Innodx Corporation Information10.1.2 Innodx Description, Business Overview10.1.3 Innodx Thyroid Stimulating Hormone Test Kit Sales, Revenue and Gross Margin (2015-2020)10.1.4 Innodx Thyroid Stimulating Hormone Test Kit Products Offered10.1.5 Innodx Recent Developments10.2 Bioscience10.2.1 Bioscience Corporation Information10.2.2 Bioscience Description, Business Overview10.2.3 Bioscience Thyroid Stimulating Hormone Test Kit Sales, Revenue and Gross Margin (2015-2020)10.2.4 Innodx Thyroid Stimulating Hormone Test Kit Products Offered10.2.5 Bioscience Recent Developments10.3 Daan10.3.1 Daan Corporation Information10.3.2 Daan Description, Business Overview10.3.3 Daan Thyroid Stimulating Hormone Test Kit Sales, Revenue and Gross Margin (2015-2020)10.3.4 Daan Thyroid Stimulating Hormone Test Kit Products Offered10.3.5 Daan Recent Developments10.4 Ying Sheng Biology10.4.1 Ying Sheng Biology Corporation Information10.4.2 Ying Sheng Biology Description, Business Overview10.4.3 Ying Sheng Biology Thyroid Stimulating Hormone Test Kit Sales, Revenue and Gross Margin (2015-2020)10.4.4 Ying Sheng Biology Thyroid Stimulating Hormone Test Kit Products Offered10.4.5 Ying Sheng Biology Recent Developments10.5 Easydiagnosis10.5.1 Easydiagnosis Corporation Information10.5.2 Easydiagnosis Description, Business Overview10.5.3 Easydiagnosis Thyroid Stimulating Hormone Test Kit Sales, Revenue and Gross Margin (2015-2020)10.5.4 Easydiagnosis Thyroid Stimulating Hormone Test Kit Products Offered10.5.5 Easydiagnosis Recent Developments10.6 Tellgen10.6.1 Tellgen Corporation Information10.6.2 Tellgen Description, Business Overview10.6.3 Tellgen Thyroid Stimulating Hormone Test Kit Sales, Revenue and Gross Margin (2015-2020)10.6.4 Tellgen Thyroid Stimulating Hormone Test Kit Products Offered10.6.5 Tellgen Recent Developments10.7 Bioscience10.7.1 Bioscience Corporation Information10.7.2 Bioscience Description, Business Overview10.7.3 Bioscience Thyroid Stimulating Hormone Test Kit Sales, Revenue and Gross Margin (2015-2020)10.7.4 Bioscience Thyroid Stimulating Hormone Test Kit Products Offered10.7.5 Bioscience Recent Developments10.8 BGI10.8.1 BGI Corporation Information10.8.2 BGI Description, Business Overview10.8.3 BGI Thyroid Stimulating Hormone Test Kit Sales, Revenue and Gross Margin (2015-2020)10.8.4 BGI Thyroid Stimulating Hormone Test Kit Products Offered10.8.5 BGI Recent Developments10.9 Chivd10.9.1 Chivd Corporation Information10.9.2 Chivd Description, Business Overview10.9.3 Chivd Thyroid Stimulating Hormone Test Kit Sales, Revenue and Gross Margin (2015-2020)10.9.4 Chivd Thyroid Stimulating Hormone Test Kit Products Offered10.9.5 Chivd Recent Developments

11 Thyroid Stimulating Hormone Test Kit Upstream, Opportunities, Challenges, Risks and Influences Factors Analysis11.1 Thyroid Stimulating Hormone Test Kit Key Raw Materials11.1.1 Key Raw Materials11.1.2 Key Raw Materials Price11.1.3 Raw Materials Key Suppliers11.2 Manufacturing Cost Structure11.2.1 Raw Materials11.2.2 Labor Cost11.2.3 Manufacturing Expenses11.3 Thyroid Stimulating Hormone Test Kit Industrial Chain Analysis11.4 Market Opportunities, Challenges, Risks and Influences Factors Analysis11.4.1 Thyroid Stimulating Hormone Test Kit Industry Trends11.4.2 Thyroid Stimulating Hormone Test Kit Market Drivers11.4.3 Thyroid Stimulating Hormone Test Kit Market Challenges11.4.4 Porters Five Forces Analysis

12 Market Strategy Analysis, Distributors12.1 Sales Channel12.2 Distributors12.3 Downstream Customers

13 Research Findings and Conclusion

14 Appendix14.1 Methodology/Research Approach14.1.1 Research Programs/Design14.1.2 Market Size Estimation14.1.3 Market Breakdown and Data Triangulation14.2 Data Source14.2.1 Secondary Sources14.2.2 Primary Sources14.3 Author Details14.4 Disclaimer

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Thyroid Stimulating Hormone Test Kit Market In-Depth Analysis Of Competitive Landscape, Executive Summary, Development Factors 2026 | Innodx,...

Recommendation and review posted by Bethany Smith

Tremendous progress has been made to understand the strategies that can be used to overcome ESR1 mutations in estrogen receptor (ER)positive breast cancer, said Debu Tripathy, MD, who added that potent selective ER modulators (SERMs) may be the key to combat these mutations.

Selective [ER] modulators can probably, to some extent, be effective [against] ESR1-mutant cells, said Tripathy. The effect to which they can reverse resistance probably depends on many aspects of the agent. These need to be formally studied not just in the lab, but in clinical trials. We are starting to get some hints of that [work], but its just the beginning.

ESR1 mutations generally arise following treatment with an aromatase inhibitor (AI), explained Tripathy, so acquiring genomic information after a patient progresses is critical to inform treatment selection.

The novel SERM lasofoxifene is currently being investigated in combination with the CDK4/6 inhibitor abemaciclib (Verzenio) in the phase 2 ELAINEII trial (NCT04432454) in patients with advanced or metastatic ER-positive, HER2-negative breast cancer whose tumors harbor an ESR1 mutation. Moreover, in May 2019, the FDA granted a fast track designation to lasofoxifene for the treatment of female patients with ER-positive, HER2-negative metastatic, ESR1-mutant breast cancer.

In an interview with OncLive, Tripathy, professor of medicine and chair of the Department of Breast Medical Oncology at The University of Texas MD Anderson Cancer Center, discussed the role of CDK4/6 inhibitors in ER-positive, HER2-negative breast cancer, the emergence of SERMs, and the growing understanding of ESR1 mutations in this space.

Tripathy: When patients progress on a CDK4/6 inhibitor, I will generally discontinue the use of CDK4/6 inhibitors. No clear data [show] that patients who become resistant [to a CDK4/6 inhibitor] may be sensitive to other [CDK4/6] inhibitors; however, some anecdotal datafrom individual hospital series suggest there could be some non-overlapping sensitivity.

However, we have many other options, which is why I will generally move on to another form of therapy. We need to formally study the impact of 1 CDK4/6 inhibitor after progression on another because we may find that some of these agents perform better in that setting.

I tend to get genomics at the very beginning when patients are newly diagnosed, although I may not use that information in the first-line setting. However, it is good to have [the genomic information], especially for truncal mutations. [Truncal mutations] tend to be prevalent in most of the cells, such asPIK3CAmutations.ESR1mutations tend to be subclonal and may not be present [up front] but may arise later after the patient has been on an [AI].

If I havent gotten [genomic information] at the beginning, I will certainly get it at the time of progression on first-line therapy.

ESR1 mutations tend to arise in the presence of pretreatment, particularly with estrogen-deprivation therapy, which pharmacologically, would be AIs. The Cancer Genome Atlas published that ESR1 mutation rates were very low, at perhaps 1% or so at diagnosis and based on the patients primary tumor. However, [ESR1mutations] really [arise] after exposure to AIs.

That makes sense because AIs work by depriving estrogen from the environment. To be activated, ERs need to bind to estrogen. So, [AIs] select for any mutations that may occur where a mutation [is present] in the ER that allows it to be activated without the presence of estrogen; that is what most activating ESR1mutations do. Specifically, upon exposure to AIs, is when we start to see these mutations arise.

The PADA-1 trial showed that ESR1 mutations can be acquired and they can be subclonal, meaning that you can see a very low fraction of all the tumor DNA that has that mutation. However, you cant underestimate that power of a small fraction of activated ESR1-mutant cells. We do see that pattern of resistance. [Additionally, the trial showed] that patients can have multiple clones.

How do you combat ESR1 mutations? One way is to totally take them out of the equation and to target them for downregulation or proteasomal degradation, which is what selective ER downregulators like fulvestrant [Faslodex] do. However, they dont do it completely; these drugs dont completely circumvent resistance. Another way is to use [SERMs] that may not necessarily inactivate the ER, but instead, modulate the ER in the way it behaves, the conformation of it, and how it binds to co-activators, co-receptors, and co-repressors. [Doing this], ultimately, mediates the expression of genes that guide what estrogen does, which is generally a growth signal.

Lasofoxifene does have the ability to downregulate the transactivating nature of the ER, including ESR1mutations. In the lab, we can study how well an ER is able to activate the genes it targets. ERs are known to target numerous genes of interest that lead to cell growth. We can measure to what extent a drug will interact with ESR1 so that it negatively regulates it. In other words, the genes that are normally transcribed by estrogen are not transcribed. More importantly, growth is arrested. That has been demonstratedin vitroandin vivousing ESR1-mutant models.

Those data are compelling. They show that we can get growth inhibition in ESR1mutations and that it can be potentially aided with CDK4/6 inhibitors. Although I dont have the exact data at hand, I have seen examples of this and other data that show [tumor growth] can be reversed in cell-line models.

What we see in those cell-line modelseven in animal models, which are more accurate but may not be the whole storymay not turn out to be the case in the tumor microenvironment and all of the other factors involved. Therefore, although this is very supportive and raises enthusiasm for getting these types of drugs into clinical trials, we need to wait to see what happens when patients are taking these drugs.

The ELAINE trial is comparing fulvestrant with lasofoxifene in patients with ESR1 mutations. Its a direct test of the hypothesis that [lasofoxifene] may be more favorable than [fulvestrant], which we now consider a reasonable drug to use when we see ESR1 mutations or in the second line in general.

ELAINEII is designed to move [lasofoxifene] further, combining it with a CDK4/6 inhibitor. It will allow patients who have seen prior CDK4/6 inhibitors [to enroll].There is some anecdotal evidence that responses have been seen with abemaciclib after progression on other CDK4/6 inhibitors.

The approval of abemaciclib was based on a trial that showed responses in refractory hormone receptorpositive disease as a single agent, but those patients had not been previously exposed to CDK4/6 inhibitors. We believe that the combination of these 2 different strategies could bring about more responses and longer time to progression.

One of the issues is pairing CDK4/6 inhibitors with different endocrine therapies; we havent formally compared that. We do know from the FALCON trial that, when using endocrine therapies alone, fulvestrant is slightly better than AI therapy, particularly in patients who havent been treated before or have non-visceral disease. Then, the MONALEESA-3 study was a trial that took advantage of the FALCON findings and compared treatment with fulvestrant alone versus fulvestrant plus ribociclib [Kisqali] regardless of first- or second-line therapy. That study showed a significant improvement in outcomes with a hazard ratio of around 0.5, which has been seen before.

The PARSIFAL trial, on the other hand, was a direct comparison with palbociclib. Patients received an AI or fulvestrant. The trial did not show a difference in progression-free survival.We are left without knowing what population fulvestrant might be best for, but certainly fulvestrant is a reasonable option in the first- or second-line setting. We have less data regarding what to do in the second line for patients who received fulvestrant up front, but the PARSIFAL and MONALEESA-3 studies showed that [ribociclib and palbociclib] are both reasonable agents to use and could be building blocks for [combinations] with other targeted agents.

The sub-classification of the breast cancer subtypes is very important in general. In breast cancer, not all patients with luminal A or luminal B [disease] are the same. There may be certain aspects about the different pathways involved in growth and other cellular functions, such as invasion and apoptosis that may vary depending on different gene profiling. Gene profiling is basically a way to categorize cancers, but if we can categorize them in functionally relevant ways, then we are really making advances.

This takes studying large numbers of patients, ideally in the context of a clinical trial where they are being treated similarly or we are comparing 1 treatment with another. Then, we can dissect the different molecular profiles that may predict a benefit. More importantly, we can use that information about the molecular profiles to identify mechanisms of resistance that could inform newer strategies.

Not all mutations are the same. There may be certainESR1mutations that are generated in certain situations and under certain treatments that we need to understand better. What is really fascinating is trying to understand the functional consequences of ESR1 mutations, not only in terms of proliferation, but in terms of many other phenotypes that we are interested in targeting, such as metabolic activity, DNA repair, or other hallmarks of cancer. Whether it is invasion, the ability to resist apoptosis, or immunogenicity is critical. Studies in the basic aspects of what ERS1 mutations do [are important]. [Also, evaluation of] the nitty gritty molecular structure and how the ER interacts with co-activators, co-repressors, and other aspects of the transcriptional machinery that make the ER work [is needed] to understand what ESR1 does.

Of course, we are aware of many other mutational isoforms, such asRASmutations and growth factor mutations, like exon 20. We need to understand the inner workings of what these mutations cause. When you think about it, cancer is selection of the fittest. Cancer cells do have a higher mutational rate. Many of the mutations that arise out of accident lead to cell death. However, it is those that lead to cell advantage that perpetuate. By understanding the most common driver mutations that arise over time, we can start to develop therapies against each one. Although, there will always be rare mutations that are going to be more difficult to understand and target.

Link:
Lasofoxifene Emerges as Understanding of ESR1 Mutations Expands in ER+/HER2- Breast Cancer - OncLive

Recommendation and review posted by Bethany Smith

PLATTSBURGH We have all experienced grief and loss this year, Bonnie Black says.

That ranges from loss of junior prom and vacations, to not working in your office and having to give up typical holiday experiences due to the COVID-19 pandemic.

This is all new; it isnt a choice we made, said Black, director of Employee Assistance Services at Behavioral Health Services North.

It was foisted upon us due to the pandemic, and there wasnt much notice.

NEED HUMAN CONNECTION

Remote learning, contemplation of what defines essential workers and isolation have been part of this shared human experience brought on by the coronavirus, Black said.

Look at these holidays: Hanukkah, Christmas, Kwanzaa, New Years. A good number of us connect physically with family or friends. We have not had the human touch, the human hug in so long.

Were social animals, we need a human connection.

Studies conductedthis year demonstrate the resulting negative impacts on human lives, such as increased anxiety, depression and substance misuse.

We are all empathizing with loss, grief, uncertainty, and all of that produces stress, which produces cortisol, Black said. When our cortisol hormone is increased, we have very negative physiological impacts on our heart, kidneys, brain function.

So we need to look at how do we stay resilient.

SLEEP, REDUCE SUBSTANCES

Black first recommends ensuring quality sleep; adults should get seven to nine hours most nights.

Our brains do their work when were sleeping. Thats why we need sleep, to let the brain reorganize itself.

Over the holidays especially, people should reduce the amount of substances they choose to use, perhaps subbing in something like sparkling grape juice, Black said.

We have to be very careful because our bodies and brains are really experiencing an immense of amount of stress that theyre not used to.

GRATITUDE, EXERCISE

Black additionally advised looking for moments of gratitude and joy, even if its just two squirrels playing in your backyard.

Smiling and laughter results in the release of endorphins, which help destroy the cortisol produced by stress.

Apps like Headspace or Calm, a podcast that you enjoy and exercise can also do the trick, Black said.

And exercise helps people to connect with nature.

We did it almost instinctively last spring: everyone went to Lowes or Aubuchon and bought landscaping materials, tools and made plans," Black said.

We got out into nature, the dirt under the fingernails that made us feel good.

CONTROL, SYSTEMS

Looking ahead to maintaining those yard projects and just starting to plan and make lists are helpful tools, Black said.

We believe weve lost control, and we have lost some.

What do you have control over? What is very important every day?

Control may look as simple as getting dressed and going downstairs for breakfast each day, deciding which days are laundry or trash days, or taking time to reach out to one person one day a week, Black said.

We havent had to think of life like that, but when we have a system and have control, whatever the system may be, our brains and our bodies can actually relax and be in a less stressed state.

That also involves monitoring consumption of news media, which largely does not create endorphins that reduce stress, she added.

Because we cant control our external world much, we need to find ways to control our internal world. When we put our head to the pillow, whats the one thing we can be grateful for, how many people smiled at me, how many people did I smile at.

REACH OUT

Black said suicide rates are going up, even though they normally go down this time of year. She noted in particular increases in attempts and deaths by suicide among first responders, firefighters and police.

We have to be very, very aware that there are some people under some really undue stress, stressors they never really signed up for."

Reaching out to people feeds into the human connection that everyone needs, Black said.

If you havent seen somebody at work or school or they havent been on the Zoom call, shoot an email, shoot a text.

You be the one to reach out. You could bring that moment of joy to their life that they havent been able to find or see.

Zoom or Facetime conversations, or short emails, videos or messages can say many things.

I like you. I remember you. I want to be connected with you, Black said.

Thats the gift we can give that, monetarily, does not cost us anything but fulfills that need for human connection.

Email Cara Chapman:

cchapman@pressrepublican.com

Twitter: @PPR_carachapman

WHERE TO GET HELP

Seek help if youre considering suicide.

For emotional crises:

National Crisis Text Line: 74141

Text: GOT5 to reach a crisis counselor in New York State.

The toll-free 24-hour North Country Crisis Helpline number is (866) 577-3836. That number is answered by members of the Clinton County Mobile Crisis Team Monday through Friday from 8:30 a.m. to 7:30 p.m. Outside those hours, it is answered by an on-call crisis service.

Out-of-county calls are accepted but other options are:

The National Suicide Prevention Lifeline, (800) 273-TALK (8255). Press 1 for confidential help for veterans and their families.

The Essex County Mental Health Association Hope Line, (800) 440-8074. That number is staffed 24-7; leave a message and your call will be returned within 10 minutes.

Visit the Clinton County NY Coalition to Prevent Suicides Facebook page for education and resources.

If a friend of yours posts suicidal content on Facebook, let someone know an adult, the police. And visit http://tinyurl.com/nuvnm29 to report it.

National Alliance on Mental Illness: Champlain Valley is a resource for suicide-survivor support. Call (518) 561-2685.

For counseling, contact:

Clinton County Mental Health, (518) 565-4060.

Behavioral Health Services North Adult Clinic, (518) 563-8000 (staffed around the clock).

Essex County Mental Health Clinic, (518) 873-3670; after-hour emergencies, (888) 854-3773.

In northern Franklin County, around the clock, (518) 483-3261; southern Franklin County, (518) 891-5535.

Additional resources, such as for parents and educators, are available on the Mental Health Association of New York State's website,mhanys.org.

We are making critical coverage of the coronavirus available for free. Please consider subscribing so we can continue to bring you the latest news and information on this developing story.

Go here to see the original:
Tips for mental health resilience in the time of COVID - Plattsburgh Press Republican

Recommendation and review posted by Bethany Smith

Although research has cemented BMPR2 mutations as having associations with the development of pulmonary arterial hypertension, the germline mutations are not the only culprit.

Pulmonary arterial hypertension (PAH) is a multifaceted condition, consisting of interactions between estrogens, estrogen metabolites, and BMPR2 signaling, according to new research.

Although research has cemented BMPR2 mutations as having associations with the development of PAH, the germline mutations are not the only culprit, say the researchers, who argue that other, additional genetic and environmental factors play a role. Mutations in several components of the BMPR2 signaling pathway have also been linked to the development of PAH, including ALK1, SMAD8, BMP9, and CAV1.

Despite the strong association between BMPR2 mutations and the development of PAH, and despite the high frequency of BMPR2 mutations in heritable PAH, having a BMPR2 mutation alone is not sufficient; heterozygous carriers of deleterious BMPR2 mutations only have an approximately 20% lifetime risk of disease penetrance, explained the researchers. Decades of investigation have revealed that there are likely multiple genetic and environmental second hits that may be necessary to spur PAH development in the setting of a deleterious BMPR2 mutation.

The intricacies of PAH can be highlighted by the role estrogen and estrogen metabolites play in the condition. For example, some animal models have suggested that the 2 protect against PH in the presence of other provoking factors while human studies have suggested that female predominance actually heightens the risk of PAH. And while females who carry deleterious BMPR2 variants are more likely to develop PAH, they are less likely to have severe disease than men.

However, the researchers argue that the role of estrogen and estrogen metabolites does not paint a full picture of the sex differences in PAH. These differences include those in right ventricular (RV) adaption to chronic pulmonary hypertension, with some research suggests that females might have better RV function than males. According to the researchers, other sex-driven differences, like testosterone and progesterone and nonhormonal sex effects, may contribute to the impact of sex.

Similar to the BMPR2 signaling cascade, essential components of estrogen signaling pathways are expressed in the [endothelial cells], vascular [smooth muscle cells], and fibroblasts responsible for vascular remodeling and the development of PAH, wrote the researchers, noting that estrone, estradiol, and estriol, along with their metabolites signal through estrogen receptors ER and ER and the newly discovered G-protein-coupled receptor.

In their paper, the researchers look at the relationship between estrogen and BMPR2, writing that there have been inclinations that baseline BMPR2 expression and signaling may be reduced in females. They suggest that this deficiency in BMPR2 expression may be that second hit to spur the development of PAH. However, they caveat that the relationship between estrogen and BMPR2 is complex and may be dependent on several factors, such as age, menopausal status, cell type studied, and dose responses and time courses.

Reference

Cirulis MM, Dodson MW, Brown LM, Brown SM, Lahm T, Elliot G. At the X-roads of sex and genetics in pulmonary arterial hypertension. Genes (Basel). Published online November 20, 2020. doi:10.3390/genes11111371

See the article here:
Sex, Genetics, and the Relationship Between the Two in Pulmonary Arterial Hypertension - AJMC.com Managed Markets Network

Recommendation and review posted by Bethany Smith

Did you know that you can estimate a persons height based on their foot size? If you wore a size womens 5, you would be approximately 4-feet-9. But how big, on average, is a womens foot size?

CREDIT: Amazon

The most common foot size for the average American female is somewhere between an 8.5 and a 9, which might surprise some people since in the 1970s the average foot size used to be 7.5 until only recently.

According to a report done by the National Shoe Retailers in 2012, the average womans foot has grown by more than a size over the last three decades.

So, why are our feet getting bigger?

On average, Americans are getting taller and heavier, which causes an increase of the size of their feet in proportion to their bodies. Taller women in general seem to have larger feet than shorter women, since their bodies require additional support to balance.

Related

A lot of our shoe sizes differ based on genetics and environment. Our feet can expand as we age and they begin to lose their elasticity. Womens shoe sizes can also switch during pregnancy or menopause. It is recommended you measure your feet occasionally even if you think you know your shoe size as it may change.

According to the American Orthopedic Foot and Ankle Society, 88% of women wear the wrong shoe size. This is likely due to improper fitting, lack of knowing their real shoe size and settling for a shoe that fits well enough.

To determine your own shoe size, its best to measure your feet at the end of the day after youve been walking because walking can slightly increase the size of your feet. Its suggested that you measure your feet wearing the socks or stockings that you will wear in the shoes you plan to purchase.

Even though on average womens feet are between 8.5 and 9, the most commonly sold shoe size is a 7, but just because this is the size that most women purchase does not mean that they are wearing the correct size.

While women may have felt ashamed of their larger foot sizes in the past, recent footwear trends have grown to embrace bigger feet. In fact, some big celebrity names have large feet, including Kate Winslet (shoe size 11) and Rhianna (size 9).

Many shoe retailers have accommodated to the increase in foot size, switching to designing larger and wider shoe sizes.

Smallest Woman Alive: Jyoti Amge

CREDIT: Courtesy of Guinness World Records

Currently, the smallest woman alive is Indian Actress Jyoti Amge. Amge stands at only 2 feet and three-quarters inches and her feet only measure 3.72-inches long, which is a toddler size 2 in the U.S. She was officially declared the worlds smallest woman by the Guinness World Records in 2011. Amge has starred in both American Horror Story and the Indian television show Bigg Boss 6.

See the original post:
What Is the Average Shoe Size for Women? Its Bigger Than You Might Think - Footwear News

Recommendation and review posted by Bethany Smith