Feb. 11, 2013 In a study to be presented on February 14 at the Society for Maternal-Fetal Medicine's annual meeting, The Pregnancy Meeting , in San Francisco, researchers will report that variation in a gene involved in inflammation is associated with developmental problems after preterm birth in females, but not males.

This randomized study, Sex-specific genetic susceptibility to adverse neurodevelopmental outcome after early preterm birth, may improve understanding of how developmental problems occur after preterm birth and may help identify prevention strategies.

"Preterm birth is the leading cause of childhood brain injury," said the study's author, Erin Clark, MD. "Compared to preterm girls, preterm boys are more likely to die, and survivors are more likely to have long-term problems, including disability and cerebral palsy. We don't understand why preterm boys are at a disadvantage compared to girls."

Through her study, Clark, assistant professor of Maternal-Fetal Medicine at the University of Utah School of Medicine, determined whether genetic variants influence the risk of developmental problems after a preterm birth, and whether there is a difference in risk factors between males and females.

Clark evaluated patients previously enrolled in a randomized trial of magnesium sulfate before preterm birth for prevention of cerebral palsy. She evaluated children that died before their first birthday, or developed cerebral palsy or other developmental problems by age 2 years, and compared them to healthy children.

The research shows a variant in the inflammation gene, interleukin 6, was associated with developmental problems in females but not in males. Treatment with magnesium sulfate before birth didn't appear to change this risk.

"These results add to the evidence that inflammation genes play a role in risk of brain injury in preterm children. In addition, they suggest that genetic risk factors for brain injury after early delivery may be different in boys and girls," said Clark. "However, the effect of genes and gender on outcomes after preterm birth remains poorly understood. Additional research is necessary in order to better understand the differences in outcomes between males and females born preterm."

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Agent Orange(tga genetics) Mystery strains
Cannabis grow

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Making Ripples in the World
Every winter our students bring their energy, insight, and ambition to the world for seven weeks during Field Work Term. Last year students volunteered more than 25000 hours of time collectively helping to find shelter for homeless women and children; teaching ordinary citizens how to decode their own genetics; making green building models; going door-to-door for the EPA; and lobbying for healthcare and livable wages. Some have even created their own non-profit organizations. Every gift to Bennington is a gift to the world. Make your gift to The Bennington Fund today.

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"Truth About Suicide" Panel On Genetics Suicide | Larry King Now | Ora TV
Larry King interviews the Truth About Suicide panel featuring mental health experts celebrities. Pattie Mallette, Cesar Milan "The Dog Whisperer," Dr. Drew Pinsky and Dr. Dan Reidenberg discuss if suicide is genetic. Watch this full episode of "Larry King Now" on Ora TV Hulu: on.ora.tv ______ SUBSCRIBE to Ora TV #39;s YouTube Channel: http://www.youtube.com FACEBOOK: http://www.facebook.com http://www.facebook.com TWITTER: twitter.com Use #LarryKingNow to make comments ask us questions on Twitter! CHECK OUT Larry #39;s daily show, "Larry King Now," on Hulu: http://www.hulu.com Comment ask Larry questions on Twitter: twitter.com

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Our Genes
Afro-Textured Hair Genetics Video (part of beta launch of Graduate Thesis website)

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06- Cancer Genetics - Interview with Dr. Gerard Evan
For additional information visit http://www.cancerquest.org Dr. Gerard Evan is the Gerson and Barbara Bass Bakar Distinguished Professorship in Cancer Research at UCSF. Dr. Evan works on developing new ways to study cancer development and treatment. He has created a novel system to study cancer development in mice using a #39;switchable #39; version of the myc oncogene. In this interview, Dr. Evan discusses the current cancer research through mice models. To learn more about cancer and watch additional interviews, please visit the CancerQuest website at http://www.cancerquest.org.

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How Do Genetics Influence Your Menopause Symptoms?
http://www.menopausepower.com Menopause Power is designed to empower you to take charge of your own menopause. I began this initiative to educate women and physicians about why it is so important to change the way we traditionally view menopause, and to share my time-tested methods for treating menopause effectively and safely. To learn more, please visit my website at http://www.menopausepower.com

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Genetics Part 1
Introduction to Gregor Mendel and his experiments with the Garden Pea Plant.

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Genetics Part 2
Introduction to Gregor Mendel and his experiments with the Garden Pea Plant.

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Mendel #39;s 1st and 2nd Law: Simple Explanation for Human cells
I tried to explain Mendel #39;e two laws here as simple as possible. If you face difficulties please leave comments. I think for understanding genetics these two laws are very fundamental. Most of we are learned these laws in high school level for peas experiments using punnet squares, but I explained here in meiosis perspective of human cells. Shortly, First law gives exact Parental Chromosomes, ie segregation. Second law gives Parental chromosomes and Mixed (father and mother) chromosomes, ie independent events. Second law is also segregation but the pattern of segregation is independent on parents! Outcome: 1st law--- give 100% (4) parental ditype in gamets (50% (2)father chromosomes and 50% (2) mother chromosomes) 2nd law--- give 50% (4) parental ditype in gamets (25% (2)father chromosomes and 25% (2) mother chromosomes) AND 50% (4)non- parental ditype (mixed) in gamets (25% (2)father +mother mixed chromosomes and 25% (2) mother+father chromosomes)

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2Nuance Makes All the Difference
It #39;s Genetics

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rK Genetics - 1v6 Clutch
rK Genetics holding down for the squad

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Risky IPOs: Cancer Genetics, Orchid Island Capital
IPO Desktop President Francis Gaskins believes these IPOs are only for risk takers. Cancer Genetics has lost money and Orchid Island suffers from legal problems.

By: TheStreetTV

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ga ga, tc gac ga ga (to be or not to be)
Breaking down the chimps in a room creationist fallacy to match genetics a little better. Those chimps wouldn #39;t be typing with a full alphabet.

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Feb. 11, 2013 Scientists who built a synthetic gene circuit that allowed for the precise tuning of a gene's expression in yeast have now refined this new research tool to work in human cells, according to research published online in Nature Communications.

"Using this circuit, you can turn a gene from completely off to completely on and anywhere between those two extremes in each cell at once. It's a nice tool if you want to know what happens at intermediate levels of gene expression. There has been no such system so far, but now it is available for mammalian cell research," said senior author Gbor Balzsi, Ph.D., associate professor in The University of Texas MD Anderson Cancer Center Department of Systems Biology.

Present options for altering gene expression in human cells are blunt instruments by comparison. Knocking out a gene eliminates its expression completely. Inhibiting it with RNA interference dials it partially down and can affect other genes. Inserting a gene expression vector into cells overexpresses the gene, but it's usually uncontrolled. Commercially available versions can switch a gene on or off, but cannot precisely dial between these extremes.

"For cancer research, the system will allow scientists to test the boundaries of a gene known to confer resistance to a drug in cancer cells by dialing its expression to different levels and treating the cells with the drug," said first author Dmitry Nevozhay, M.D. Ph.D., instructor in Systems Biology.

"Likewise, such a system would allow personalized gene therapy, by precisely tuning the therapeutic gene level expression depending on disease progression and the patient's need," Nevozhay said.

In microbial or yeast biology research scientists have started to understand and manipulate gene function quantitatively, almost like we understand electronic circuits, Balzsi said. "This makes research in those areas more amenable to engineering and mathematical characterization, -- but that's not true for human cells, and part of the problem is that tools that tune gene expression have been lacking."

A step-by-step guide for others to build mammalian synthetic gene circuits By refining their circuit to work in a human breast cancer cell line, the team demonstrated that their approach can be used in mammalian cells while offering a step-by-step guide that other researchers could follow to build other synthetic circuits for use with other genes.

"With all of our steps reported, if someone wants to build another type of gene expression switch, or oscillator, they could build the circuit in fast-growing yeast cells, where it can be engineered and optimized quickly and reliably," Balzsi said. "Once you know it works in yeast, you know the steps to make it function in human cells. This process is similar to extensive testing of NASA's space operations on Earth before actually carrying them out in space."

Synthetic biologists apply engineering principles to design and build new biological systems for predefined purposes.

In yeast, Balzsi and colleagues synthesized a gene circuit designed to control the level of gene expression precisely using the tetracycline repressor.

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Spinal Cord Injury Research Supported
The Senate Health, Human Services and Housing Committee endorsed an effort to create an $8 million dollar grant program for the research into treating spinal cord and traumatic brain injuries. The $8 million dollar grant, if it becomes law, would be divided equally between the two research areas.

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Genetic Engineering CARTOON.mp4

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Engineers at MIT have developed genetic circuits in bacterial cells that not only perform logic functions, but also remember the results. Credit: LIANG ZONG AND YAN LIANG

MIT engineers have created genetic circuits in bacterial cells that not only perform logic functions, but also remember the results, which are encoded in the cell's DNA and passed on for dozens of generations.

The circuits, described in the Feb. 10 online edition of Nature Biotechnology, could be used as long-term environmental sensors, efficient controls for biomanufacturing, or to program stem cells to differentiate into other cell types.

"Almost all of the previous work in synthetic biology that we're aware of has either focused on logic components or on memory modules that just encode memory. We think complex computation will involve combining both logic and memory, and that's why we built this particular framework to do so," says Timothy Lu, an MIT assistant professor of electrical engineering and computer science and biological engineering and senior author of the Nature Biotechnology paper.

Lead author of the paper is MIT postdoc Piro Siuti. Undergraduate John Yazbek is also an author.

More than logic

Synthetic biologists use interchangeable genetic parts to design circuits that perform a specific function, such as detecting a chemical in the environment. In that type of circuit, the target chemical would generate a specific response, such as production of green fluorescent protein (GFP).

Circuits can also be designed for any type of Boolean logic function, such as AND gates and OR gates. Using those kinds of gates, circuits can detect multiple inputs. In most of the previously engineered cellular logic circuits, the end product is generated only as long as the original stimuli are present: Once they disappear, the circuit shuts off until another stimulus comes along.

Lu and his colleagues set out to design a circuit that would be irreversibly altered by the original stimulus, creating a permanent memory of the event. To do this, they drew on memory circuits that Lu and colleagues designed in 2009. Those circuits depend on enzymes known as recombinases, which can cut out stretches of DNA, flip them, or insert them. Sequential activation of those enzymes allows the circuits to count events happening inside a cell.

Lu designed the new circuits so that the memory function is built into the logic gate itself. With a typical cellular AND gate, the two necessary inputs activate proteins that together turn on expression of an output gene. However, in the new circuits, the inputs stably alter regions of DNA that control GFP production. These regions, known as promoters, recruit the cellular proteins responsible for transcribing the GFP gene into messenger RNA, which then directs protein assembly.

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Cell circuits remember their history: Engineers design new synthetic biology circuits that combine memory and logic

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Feb. 10, 2013 Researchers at the University of Minnesota's Department of Integrative Biology and Physiology and the Lillehei Heart Institute have utilized molecular genetic engineering to optimize heart performance in models of diastolic heart failure by creating an optimized protein that can aid in high-speed relaxation similar to fast twitching muscles.

Within heart cells, calcium plays a major role in orchestrating normal heart pump function. However, in diastolic failure the calcium signaling process is slowed; calcium levels rise to the peak needed for the squeezing action of the heart but don't then drop quickly enough for an efficient relaxation period -- the condition known as diastolic heart failure.

University researchers were able to pinpoint a specific protein, parvalbumin -- which aids in high-speed relaxation of fast twitching muscles in nature -- and optimize it to become a calcium sponge for heart muscle. As a result, the optimized protein, ParvE101Q, soaks up excess calcium at a precise instant, allowing the heart to relax efficiently after contraction.

The advance offers a solid conceptual step forward in solving the puzzle of diastolic heart failure. The next step will be determining the best possible small molecule or gene delivery mechanism for the protein, which should allow the discovery to be used in clinics.

Their approach is outlined in the latest issue of Nature Medicine.

"In nature, there are unique organisms known to be able to contract and relax muscles quickly," said Joseph M. Metzger, Ph.D., a University of Minnesota Medical School professor and chair of the Department of Integrative Biology and Physiology. "We hoped research and discovery could help identify what was promoting this highly efficient activity so we could harness it for use in the heart. We've discovered that our optimized variation of parvalbumin can fulfill that role by treating diastolic heart failure."

According to Metzger, who also serves as the Maurice B. Visscher Endowed Chair in Physiology, the sponge mechanism works as a temporary depot for calcium along its normal pathway. It increases productivity in the relaxation phase of the heart cycle without negatively impacting the contracting phase.

If they can develop an ideal delivery system for the optimized protein, the researchers believe they may have found a unique clinical application to treat diastolic heart failure. Heart failure is a common killer of both men and women across the country and the rate of heart failure is increasing as our population ages and as the survival rate after recovery from first heart attack goes up.

"Heart disease and heart failure rates are growing, especially as our population ages. We hope this type of discovery may one day help pave the way to a better way to treat patients," said Metzger.

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NEW YORK, Feb. 11, 2013 /PRNewswire/ -- Reportlinker.com announces that a new market research report is available in its catalogue:

Plunkett's Biotech & Genetics Industry Trends & Statistics 2013: A Summary Version of Plunkett's Biotech & Genetics Industry Almanac 2013

http://www.reportlinker.com/p01054189/Plunketts-Biotech--Genetics-Industry-Trends--Statistics-2013-A-Summary-Version-of-Plunketts-Biotech--Genetics-Industry-Almanac-2013.html#utm_source=prnewswire&utm_medium=pr&utm_campaign=Genomics

Key Features:

-Industry trends analysis, market data and competitive intelligence-Market forecasts and Industry Statistics-Buyer may register for access to search and export data at Plunkett Research Online

Pages: 77

Statistical Tables Provided: 18

Geographic Focus: Global

A condensed market research report excerpted from Plunkett's Biotech & Genetics Industry Almanac 2013, including forecasts and market estimates, technologies analysis and vital statistical tables. You will gain significant insights that can help you shape your own strategy for business development, product development and investments. -How is the industry evolving? -How is the industry being shaped by new technologies? -How is demand growing in emerging markets and mature economies?-What is the size of the market now and in the future?

Contents, Statistics, Forecasts and Analysis Include:

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Live Cell Imaging Endoplasmic Reticulum and Nucleus 15 hours 2012 Acevedo Gallegomez
This video was taken during 15 hours post-transfection a recombinant plasmid expressing one Endoplasmic Reticulum protein resident in this compartment, fused to reporter gen (Red fluorescent protein). The experiments were done by Hamlet Acevedo under tuition of Juan Carlos Gallego-Gómez. Juan Carlos Gallego-Gómez. B.Sc., Ph.D. Translational and Molecular Medicine Group (pending institutional creation process) Facultad de Medicina - Universidad de Antioquia email: juanc.gallegomez@gmail.com http://www.cnb.csic.es Viral Vector Core and Gene Therapy Neuroscience #39;s Group of Antioquia Sede de Investigación Universitaria, SIU. Medellín, COLOMBIA ZIP 05001000.

By: Juan Carlos Gallego-Gomez

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Live Cell Imaging Endoplasmic Reticulum and Nucleus 15 hours 2012 Acevedo

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A growing number of wealthy Filipinos have availed themselves of the four-day, three-night treatment in Germany. Last year alone, the clinic attended to 350 Filipinos By Alex Y. Vergara

DR.GEOFFREY Huertgen, Villa Medicas chief medical director. ALANAH TORRALBA

Jumpstarting the regeneration process to achieve longevity, glowing skin and youthful energy are just three of the claimed benefits derived by patients at Villa Medica.

The Germany-based holistic clinic specializes in fresh-cell therapy, a form of stem-cell treatment sourced from organs and tissues of unborn lamb.

Such claims may sound too good to be true, until you see the likes of former President Joseph Estrada, former first lady Imelda Marcos and Senate President Juan Ponce Enrile strutting about and plotting their next political moves like theyre in their prime.

Except for Enrile, Marcos and Estrada have nearly endorsed the clinic in Edenkoben, an hours drive south of Frankfurt, by agreeing to have their pictures and brief testimonials used in a Villa Medica brochure.

Marcos reportedly started having fresh-cell therapy injections in 1969, less than a decade after Villa Medica opened its doors for business in 1961. But the acknowledged father of fresh-cell therapy, Dr. Paul Niehans, broke ground and started his research in 1931.

Dr. Geoffrey Huertgen, Villa Medicas chief medical director, visited Manila two weeks ago to see former and potential patients. What the clinic promises, he said, is overall good health by enhancing the regeneration process. Youthful attributes such as beautiful skin and increased energy are just byproducts of the clinics holistic philosophy.

Active partner

Although fresh-cell therapy claims to help improve the condition of diabetics and kids afflicted with autism and Downs syndrome, to name a few, it doesnt promise a miracle cure for life-threatening diseases such as cancer. And since the clinics approach is organ-specific, it doesnt offer patients a one-size-fits-all therapy.

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CMC Genetic engineering
In this example of the US presidential elections, we explain how genetic engineering works. - created at goanimate.com

By: Felix Kriedemann

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CMC Genetic engineering 2
Created at goanimate.com

By: Felix Kriedemann

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NEW ORLEANS (AP) - In a promising step against a genetic disease that causes deafness and gradual loss of vision, scientists have partly restored hearing with a single injection to young mice.

Experts praised the study on Usher syndrome, published online last week by the journal Nature Medicine, but the results are still a long way from preventing the disease.

Children with Usher _ an estimated one in 6,000 to 7,500 babies worldwide _ are born deaf. The visual component of the disease, called retinitis pigmentosa, often starts in childhood, but severe problems are more likely in adolescence and young adulthood. About half of adults with Usher can still read a newspaper into their 50s.

Some groups, such as Louisianas Cajuns and Canadas Acadians, have an unusually high prevalence of the disease.

In the study, Michelle Hastings of Chicago Medical School and Jennifer Lentz of the Louisiana State University Health Science Center found that one injection allowed affected mice to hear for months.

The injection, or patch, is a laboratory-created fragment of RNA, which is a chemical cousin of DNA. The patch was designed to interfere with the effects of a faulty gene.

Its a very promising and striking finding, said Dr. Henry Paulson, a University of Michigan specialist in neurodegenerative diseases.

Curing a mouse is quite different from curing a human, he said, but hes cautiously optimistic.

Lentz, the studys lead author, and Hastings, senior author, have received a $1.3 million grant from the National Institutes of Health for four more years of mouse studies to learn the treatments physical effects and to refine timing of shots.

Time erodes the effects of the gene-inhibiting patch over the faulty RNA, and researchers plan to test whether booster shots retain hearing in treated mice. Theyre also beginning work to see whether the treatment prevents gradual loss of vision.

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