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Cells forged from human skin show promise in treating multiple sclerosis, myelin disorders

Feb. 7, 2013 A study out February 7 in the journal Cell Stem Cell shows that human brain cells created by reprogramming skin cells are highly effective in treating myelin disorders, a family of diseases that includes multiple sclerosis and rare childhood disorders called pediatric leukodystrophies.

The study is the first successful attempt to employ human induced pluripotent stem cells (hiPSC) to produce a population of cells that are critical to neural signaling in the brain. In this instance, the researchers utilized cells crafted from human skin and transplanted them into animal models of myelin disease.

"This study strongly supports the utility of hiPSCs as a feasible and effective source of cells to treat myelin disorders," said University of Rochester Medical Center (URMC) neurologist Steven Goldman, M.D., Ph.D., lead author of the study. "In fact, it appears that cells derived from this source are at least as effective as those created using embryonic or tissue-specific stem cells."

The discovery opens the door to potential new treatments using hiPSC-derived cells for a range of neurological diseases characterized by the loss of a specific cell population in the central nervous system called myelin. Like the insulation found on electrical wires, myelin is a fatty tissue that ensheathes the connections between nerve cells and ensures the crisp transmission of signals from one cell to another. When myelin tissue is damaged, communication between cells can be disrupted or even lost.

The most common myelin disorder is multiple sclerosis, a condition in which the body's own immune system attacks and destroys myelin. The loss of myelin is also the hallmark of a family of serious and often fatal diseases known as pediatric leukodystrophies. While individually very rare, collectively several thousand children are born in the U.S. with some form of leukodystrophy every year.

The source of the myelin cells in the brain and spinal cord is cell type called the oligodendrocyte. Oligodendrocytes are, in turn, the offspring of another cell called the oligodendrocyte progenitor cell, or OPC. Myelin disorders have long been considered a potential target for cell-based therapies. Scientists have theorized that if healthy OPCs could be successfully transplanted into the diseased or injured brain, then these cells might be able to produce new oligodendrocytes capable of restoring lost myelin, thereby reversing the damage caused by these diseases.

However, several obstacles have thwarted scientists. One of the key challenges is that OPCs are a mature cell in the central nervous system and appear late in development.

"Compared to neurons, which are among the first cells formed in human development, there are more stages and many more steps required to create glial cells such as OPCs," said Goldman. "This process requires that we understand the basic biology and the normal development of these cells and then reproduce this precise sequence in the lab."

Another challenge has been identifying the ideal source of these cells. Much of the research in the field has focused on cells derived from tissue-specific and embryonic stem cells. While research using these cells has yielded critical insight into the biology of stem cells, these sources are not considered ideal to meet demand once stem cell-based therapies become more common.

The discovery in 2007 that human skin cells could be "reprogrammed" to the point where they returned to a biological state equivalent of an embryonic stem cell, called induced pluripotent stem cells, represented a new path forward for scientists. Because these cells -- created by using the recipient's own skin -- would be a genetic match, the likelihood of rejection upon transplantation is significantly diminished. These cells also promised an abundant source of material from which to fashion the cells necessary for therapies.

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Cells forged from human skin show promise in treating multiple sclerosis, myelin disorders

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Spinal Cord Injury PT – Zachary – Video


Spinal Cord Injury PT - Zachary
First visit and treatment for paraplegia post spinal cord injury. Zachary had a remarkable 1st appt at Smithson Valley Physical Therapy with Selina Morgan (PT w/26 yrs Neuro therapy experience).

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Spinal Cord Injury PT - Zachary - Video

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Autism after stem cell therapy – Video


Autism after stem cell therapy
He is a known case of Autism with history of CIAB, but thereafter parents noticed delayed motor milestones in him along with delayed speech and hyperactivity. So at 2 ½ years, he was diagnosed to have Autism and put on rehabilitation program including Occupational Therapy, Physiotherapy and speech therapy. Neurologically, he has near normal tone and reflexes. On examination, he has all sensation intact and no motor weakness. He has normal vision, hearing but bisyllable speech. He has social isolation. He has no bowel and bladder control and has bed wetting present. Functionally, he needs supervision in all ADL and wheel chair bound for mobility On FIM scores he scores 62 On ISAA he scores 130 Stem Cell Therapy done at NeuroGen Brain and Spine Institute Surana Sethia Hospital Sion-Trombay Rd, Suman Ngr Opp Corporate Park, Chembur, Mumbai -- 71. Tel : 022 - 25283706, 022 - 25281610, Mob : +91 9920 200 400 http://www.neurogen.in http://www.stemcellsmumbai.com

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Autism after stem cell therapy - Video

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Stem Cell Therapy for Spinal Cord Injury – Video


Stem Cell Therapy for Spinal Cord Injury
He is a paraplegic has history of fall from height in 1993, leading to fracture D4 and paraplegia with complete bowel bladder loss. He was managed conservatively and has been undergoing rehabilitation since then. Neurologically, he is hypertonic and hyperflexic. On examination: he has sensory loss below T4. He has grade 0 muscle power in bilateral lower extremity and near normal upper extremity. He has no bowel and bladder control and is on condom catheter. He has bilateral knee flexion contracture =10. On ASIA impairment scale he scores #39;A #39;. On investigation: MRI: 6/7/2012: Wedge compression of the D4 vertebral body with a focal area of scarring within the spinal canal involving the arachnoid and the spinal cord at D3-4 level. A large cord syrinx extending cranially upto C4vetebral level with a smaller syrinx extending caudally up to D7 vertebral level. EMG / SSEP: It is suggestive of a severe lesion affecting the posterior column conduction from both lower limbs. There is evidence of predominantly Upper motor neurone lesion affecting the lower limbs. Functionally, he needs assistance in most ADL and wheel chair bound for mobility. Stem Cell Therapy done at NeuroGen Brain and Spine Institute Surana Sethia Hospital Sion-Trombay Rd, Suman Ngr Opp Corporate Park, Chembur, Mumbai -- 71. Tel : 022 - 25283706, 022 - 25281610, Mob : +91 9920 200 400 http://www.neurogen.in http://www.stemcellsmumbai.com

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Stem Cell Therapy for Spinal Cord Injury - Video

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Stem Cell Therapy With Bob – Thomas Schwarzl – SBI – Runner up 2013 – Video


Stem Cell Therapy With Bob - Thomas Schwarzl - SBI - Runner up 2013
Tom is a science punk from the Alps doing his PhD with Systems Biology Ireland. He likes to challenge everything, discover patterns in high complex problems and making them clear for everyone to understand. Besides his scientific interest in stem cell therapy and cancer research, he likes Post Secret, street art, and is planning a start-up after his PhD.

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Stem Cell Therapy With Bob - Thomas Schwarzl - SBI - Runner up 2013 - Video

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Gene May Help Predict Best Chemotherapy Treatment for Pancreatic Cancer Patients

Newswise Moffitt Cancer Center researchers have identified a gene that may better predict survival for pancreatic adenocarcinoma, the fourth leading cause of cancer deaths in the United States. Researcher Richard Kim, M.D., assistant member of the Experimental Therapeutics Program and colleagues from several other research institutions conducted a study that better defines the role of ribonucleotide reductase M1 (RRM1). The RRM1 gene encodes the regulatory subunit of ribonucleotide reductase, the molecular target of gemcitabine, a commonly used chemotherapy in pancreatic cancer.

In the study, which appeared in the Jan. 1 issue of Cancer, the research team investigated the therapeutic predictive value of RRM1 expression for the chemotherapy drug gemcitabine. They found that for patients with pancreatic adenocarcinoma removed by surgery, low RRM1 expression predicted an overall survival benefit with gemcitabine therapy. High RRM1 expression predicted benefit from non-gemcitabine therapy.

We previously hypothesized that low expression of RRM1 could predict the treatment success of gemcitabine, Kim said. This study was carried out to determine whether RRM1 expression correlates with better survival for patients receiving gemcitabine therapy.

The retrospective study included 122 patients who had undergone surgery for pancreatic adenocarcinoma from 1999 to 2007. In the subgroup of patients who received gemcitabine therapy, those with low RRM1 expression had longer overall survival and a trend toward progression-free survival. Those patients with high RRMI expression who received non-gemcitabine therapy had significantly longer overall survival and progression-free survival.

Our findings indicate that to achieve the best survival after surgical resection, the level of RRM1 expression may be used to select which patients receive gemcitabine therapy and which do not, Kim said.

The authors noted that their findings were consistent with similar studies on the role RRM1 plays in chemotherapy for patients with non-small cell lung cancer, yet their conclusions should be interpreted with caution due to their small sample size and the therapeutic success of non-gemcitabine therapies after surgery.

A validation study should be carried out before the current findings can be clinically applied, Kim added.

Kim worked with researchers from Cleveland Clinic, Case Western Reserve University School of Medicine, Veridex, LLC, and Johnson & Johnson Company on this study.

About Moffitt Cancer Center Located in Tampa, Moffitt is one of only 41 National Cancer Institute-designated Comprehensive Cancer Centers, a distinction that recognizes Moffitts excellence in research, its contributions to clinical trials, prevention and cancer control. Since 1999, Moffitt has been listed in U.S. News & World Report as one of Americas Best Hospitals for cancer. With more than 4,200 employees, Moffitt has an economic impact on the state of nearly $2 billion. For more information, visit MOFFITT.org, and follow the Moffitt momentum on Facebook, twitter and YouTube.

Media release by Florida Science Communications

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Gene May Help Predict Best Chemotherapy Treatment for Pancreatic Cancer Patients

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Microscopic Organisms – The World of Microbes. – Video


Microscopic Organisms - The World of Microbes.
A microorganism (from the Greek: mu; iota; kappa; rho; #972; sigmaf;, mikrós, "small" and #8000; rho; gamma; alpha; nu; iota; sigma; mu; #972; sigmaf;, organismós, "organism"; also spelled micro-organism, micro organism or microörganism) or microbe is a microscopic organism that comprises either a single cell (unicellular), cell clusters, or multicellular relatively complex organisms. The study of microorganisms is called microbiology, a subject that began with Anton van Leeuwenhoek #39;s discovery of microorganisms in 1675, using a microscope of his own design. Microorganisms are very diverse; they include all of the prokaryotes, namely the bacteria and archaea; and various forms of eukaryote, comprising the protozoa, fungi, algae, microscopic plants (green algae), and animals such as rotifers and planarians. Some microbiologists also classify viruses as microorganisms, but others consider these as nonliving. Most microorganisms are unicellular (single-celled), but this is not universal, since some multicellular organisms are microscopic, while some unicellular protists and bacteria, like Thiomargarita namibiensis, are macroscopic and visible to the naked eye. Microorganisms live in all parts of the biosphere where there is liquid water, including soil, hot springs, on the ocean floor, high in the atmosphere and deep inside rocks within the Earth #39;s crust. Microorganisms are critical to nutrient recycling in ecosystems as they act as decomposers. As some microorganisms can fix nitrogen, they are a vital part of the nitrogen cycle, and recent studies ...

By: shreyan chaubey

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Microscopic Organisms - The World of Microbes. - Video

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Tomato paste from Iran – Video


Tomato paste from Iran
Remember, how long you haven #39;t eaten fresh tomatoes? Real, from the village? Still having the smell of the sun and keeping the strength of land and Mother Nature. Fragrant outside, with a playful unforgettable aroma inside. When you pick a ripe tomato, it seems that nature itself gives you its heart. So, probably, would say Omar Khayyam, if he had lived in our time in his motherland - in the picturesque north-east of Iran, near steeped in centuries Nishapur. It was there, where once lived the great sage; there are wonderful gardens and vegetable plantations in a mountain glen now. There is grown the heart of Iran, which we offer you. Environmentally clean product - the famous Iranian tomato paste, during production of which was used nothing but salt and fresh tomatoes. This taste came to us from childhood, along with the taste of dates and other dried fruit. We remember what delicious borshch our mothers and grandmothers cooked for us, adding to the main ingredients the pulp of Iranian tomatoes. Today, trying to diversify the home menu, we pamper ourselves by pizzas and fell in love with vegetable stew, mushrooms, meat, cabbage, Lagman, azu, bozbash. All this will not do without adding tomato paste. And what is our disappointment when, instead of the desired deep bright orange color and sweet flavor, we get the substance of undefined quality. That #39;s because the classical content of dry matter in the tomato paste should be from 25 to 40%. It is this percentage which ...

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Tomato paste from Iran - Video

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Genetic engineering The world’s greatest scam ipad – Video


Genetic engineering The world #39;s greatest scam ipad

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Genetic engineering The world's greatest scam ipad - Video

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Simple Steps to Having a Baby Girl – Baby Gender Planning – Video


Simple Steps to Having a Baby Girl - Baby Gender Planning
Plan to have a baby girl, here #39;s how: babygenderpicker.com Choose the gender of your baby... sound impossible? I might sound that way, especially if you are not engaging in genetic engineering. The following are several strategies you can apply that may serve to increase the odds of successful baby gender choic. You can increase the likelihood of having a baby boy or a baby girl if you follow these simple steps.

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FAR CRY 3 (2014) Theatrical Fan Trailer – Video


FAR CRY 3 (2014) Theatrical Fan Trailer
The Far Cry Experience : Exclusive Episode 4 is out and 5 as well by now. This is VERSION 2 with sound fix, this is a fan fake trailer. Far Cry 3 is an open world first-person shooter set on a tropical island unlike any other. This is a place where heavily armed warlords traffic in slaves. Where outsiders are hunted for ransom. And as you embark on desperate quest to rescue your friends, you realize that the only way to escape this darkness... is to embrace it. Far Cry 3 releases December 4th on Xbox 360, PlayStation 3, and PC. For more information go to http://www.farcrygame.com. -- Story of the franchise: Far Cry is a first-person shooter video game developed by Crytek Studios and published by Ubisoft on March 23, 2004, for Microsoft Windows. Far Cry sold 730000 units within four months of release.[1] It received positive reviews upon release. The original game has since spawned a series of sequels and spin-off games and a movie. The game #39;s story follows a former US Army Special Forces operative Jack Carver, who is stranded on a mysterious archipelago. He is searching for a female journalist he was escorting after she went missing when their boat was destroyed by mercenaries. The game includes thematic elements relating to the dangers of weaponizing genetic engineering and the genocide of local islanders as can be seen by the deformed creatures created by a mad scientist named Krieger. The terrain in Far Cry varies greatly. Set on a South Pacific archipelago, the landscape ...

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FAR CRY 3 (2014) Theatrical Fan Trailer - Video

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GM crops and the food security fig leaf

By Shivani Shah

Let's talk about genetically engineered/modified (GE/GM) foods. And why the Indian Government is so adamant to have these foods commercialised in India. And why it has nothing to do with food security.

Genetic engineering is the artificial transfer of genes from one species to another plant or animal. This results in a genetically modified organism (GMO). As a result, the genetic makeup or the genetic blueprint of the organism is completely and permanently altered. The objective of modifying is to bring about a certain function for instance, in plants, producing toxic proteins to eliminate pests, developing a tolerance to agro-chemicals like herbicides, etc. In simple words it's about creating a new organism using molecular biology techniques, which will otherwise not be found in nature. So one might wonder whats wrong. Growing scientific evidence shows that GM crops are a potential threat to human health and natural biodiversity. Moreover, once released into the environment, GMOs cannot be either traced or recalled. There is also the issue of corporate control over farming by biotech seed companies.

Biotech companies such as Monsanto alter genes in a natural organism or life form like a seed and patent it. Farmers are compelled to buy their seeds and become dependent on them. Once dependent, the farmer will also have to use the associated products like herbicides as is the case with Monsanto's herbicide-tolerant crops, thus helping the company make money both from its patented seeds and trademark agro-chemicals. By controlling agriculture, companies can control food and, in fact, the whole political arena, especially in an agrarian country likes India.

In India Bt cotton is the first and only GM crop commercially cultivated. It is a patented product of Monsanto, the biggest biotech seed company in the world, also notorious for the manufacture of Agent Orange, Aspartame, and DDT among other things. It has been a decade since Bt cottons approval in India. Recent government reviews indicate that Bt cotton has neither helped increase yield nor reduce pesticide usage in cotton crops as claimed by the developers of the technology. It has in fact resulted in increasing the input costs, thereby fuelling the already existing agrarian crisis in the cotton belt of the country.

While Bt brinjal is still on hold, the industry has been trying hard to get other GM crops commercialised. GM corn is one of the 71 crops being genetically modified. It is next in the regulatory pipeline of GMOs, and could be up for commercialisation in India soon. It only seemed logical that the safety of this food product, which is going to be consumed all across India, be analysed and independently at that. This especially given that this corn is a product of Monsanto, which given its dubious history, cannot be taken at face value. Plus our regulatory system has been found wanting on many counts.

Greenpeace obtained the data on GM corn using the Right to Information Act and forwarded it to Testbiotech, an institute for independent assessment in biotechnology, for an independent analysis. In its analysis of Monsanto's corn, Testbiotech highlighted that there are many concerns about safety for human health and the environment. What was surprising was that our regulatory authorities have been permitting open release of this GM corn in the name of field trials based on the safety data generated by Monsanto in its own labs in the USA. This is a classic case of conflict of interest and what we obviously need is independent assessments. This has been pointed out innumerable times before, and reiterated in Testbiotech's report.

It also pointed out that Monsantos reports themselves were old, out-dated, and not relevant in the Indian context. The Indian government accepted tests done by Monsanto years ago on corn varieties from the US which were tested in fields in the US. The genetic makeup of corn varieties in India will certainly be different. Also, the agro-climatic conditions in the US will not be the same as here. It is impossible to know how the corn will respond in the Indian climate, on Indian soil. There are innumerable gaps in Monsantos study and it is something the Indian regulatory system needs to be extremely wary of.

This is not the first time problems of this nature have been pointed out. And this will certainly not be the last. This is because GMOs, when released into the environment, are inherently dangerous known to be damaging to the environment and to anyone who consumes it humans, animals, bees, butterflies or birds.

Yet, our government continues to bat for it spending crores of taxpayers money researching these crops by using food security as a justification. The fact of the matter is that there is no need for GM crops and the food crisis we face today is what one calls hunger in the times of plenty. Food scarcity is a result of faulty procurement policies, mismanagement of stocks, lack of adequate and proper storage, hoarding, lopsided distribution and massive leakages in the public distribution and delivery system. Today, India produces enough food for the entire population and more. In fact, we have a buffer stock of around 667 lakh tonnes, which is 2.5 times more than the government's benchmark. Where is all this food going?

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GM crops and the food security fig leaf

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Bland Strawberries Get a Genetic Tweak for Flavor

On the grocery store shelf they look plump, red and delicious. But the first bite can bring disappointment. Strawberries often dont taste as good as they look, but researchers hope to bring the flavor back to the berries.

The genome of the wild woodland strawberry offers scientists a gene parts list, within which they can look for the genetic underpinnings of flavor compounds produced in the berries, as well as many other things.

For decades, strawberries have been bred for traits that made them look good to consumers, grow well, and handle long shipment times. So, while certain traits, such as berry size, have increased, flavor has been neglected.

Kevin Folta, interim chairman of horticulture at the University of Florida, and colleagues are among those looking to change that.

Finding flavors

There are 21 species of strawberry, some with more complex genetics than others. The cultivated strawberry, first breed in 1765 in the Royal Botanical Gardens in Versailles, France, is among the more complex. Like both its ancestors, it carries eight copies of its genetic code. (By comparison, humans have two.)

In late 2010, researchers reported sequencing the genome of the woodland strawberry. With only two copies of genetic code, this once wild strawberry has become a lab rat for researchers who want to improve the more complex commercial berries.

Flavor is one area of interest. For instance, Foltas group is pursuing genes responsible for a molecule called methyl anthranilate, which has a grapelike flavor. Commercially cultivated strawberries dont produce this compound, while wild berries are rich in it.

To identify the genes and biochemistry responsible for this flavor compound, Folta and his colleaguesare tweaking the wild berrys genetic code, removing the suspect genes or prompting them to become unusually active, to see how production of the compound is affected. They have also attempted to move the flavor-producing trait into the commercial berries by breeding them with wild strawberries.

The results of these crosses indicate they are on to something: The berries smell wonderful, Folta said.

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Bland Strawberries Get a Genetic Tweak for Flavor

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Genetic engineering: It’s a technology, not an ideology

Not as simple as 'for' or 'against'

Whether you are pro or anti genetic engineering has become a divisive political issue, but remember that we are talking about technology; it shouldnt be an ideology.

Last week, BASF said it would stop seeking European regulatory approval for three genetically modified (GM) potato varieties, citing uncertainty in the regulatory environment. After a decade of research, its going elsewhere.

It was a decision welcomed by anti-GM campaigners. Jubilation exploded on various internet forums. But I think its a sad indictment of the scientific climate in Europe, when a company thats invested millions to produce potatoes that are resistant to late blight a major potato crop disease is driven out of Europe because regulators cant decide what to do about divisions in public and political opinion.

In the balance

Genetic engineering shouldnt be a political issue, no matter how much sci-fi-sensitive individuals might be reminded of the plot from The Day of the Triffids. Plants can be engineered in many ways, and their potential benefits should be balanced with an assessment of their potential detriments no matter what the technology.

Meanwhile, new GM crops are carefully considered by safety assessors around the world, including by the European Food Safety Authority (EFSA), which, if youve been paying attention to its work on health claims, has an excellent record of telling the industry to go back to the drawing board if the science isnt solid enough.

From my perspective, the reaction from many people on internet forums underlines the need for better science education, not necessarily around genetic engineering, but in order to be better critical consumers of scientific knowledge. In other words, dont believe everything youre told.

Toxic genes

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Genetic engineering: It’s a technology, not an ideology

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Lung cancer patients can benefit from genetic testing

VANCOUVER, Feb. 5, 2013 /CNW/ - Research shows the genetic make-up of a tumour can have a big impact on how a patient will respond to different treatment options.

In the most common type of lung cancer, non-small cell lung cancer (NSCLC), clinical trials have shown that people whose tumours exhibit the epidermal growth factor receptor (EGFR) gene mutation often respond better to certain targeted therapies, which can lead to better outcomes.

Approximately 10-20 per cent of all lung cancer cases have the EGFR gene mutation.i

Research also indicates that 45 per cent of Asians with NSCLC have the EGFR gene mutation,ii making genetic mutation testing in lung cancer even more relevant in BC where 12 per cent of the population is of East Asian descent.iii

East Asian, non-smoking women are at particular risk. One study showed 80 per cent of never-smoking Asian women with non-small cell lung cancer had EGFR gene mutations.iv

The BC Cancer Agency is at the forefront of lung cancer genetic testing. EGFR testing is a standard of care that is offered at the BC Cancer Agency for patients that fit the criteria.

Experts are gathering at the annual Canadian Lung Cancer Conference from February 7-8 in Vancouver to discuss EGFR mutation testing in lung cancer, among other issues that could improve patient outcomes.

Quotes:

Dr. Barbara Melosky, Chair of the Canadian Lung Cancer Conference, Associate Professor of Medicine at the University of British Columbia, Medical Oncologist at the BC Cancer Agency

"Although lung cancer is the deadliest type of cancer, with proper testing you can treat it quite effectively.

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Lung cancer patients can benefit from genetic testing

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Tiny Genetic Patch Stops Deafness

Editor's Choice Academic Journal Main Category: Hearing / Deafness Also Included In: Genetics Article Date: 05 Feb 2013 - 11:00 PST

Current ratings for: Tiny Genetic Patch Stops Deafness

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The animal study, which is still in its early stages, could eventually develop into new treatments for Usher syndrome, a congenital hearing disorder which usually goes hand-in-hand with blindness as well.

When the scientists injected the profoundly deaf mice with the genetic patch, they developed into partially hearing mice with no balance problems.

The authors explained that deafness is the most common sensory disorder. Approximately 1 in every 1,000 newborns is born with a hearing impairment. Congenital deafness is often the result of the improper development or degeneration of cochlear hair cells which form the tiny hairs in the ear that detect sound.

In one type of Usher syndrome - known as Type 1 Usher Syndrome - which French settlers brought to the USA hundreds of years ago, there is a problem with a protein called harmonin. Harmonin is required in order to form the cochlear hair cells. The same problem also causes gradual loss of vision.

In type 1 Usher syndrome, there is a mutation in the USH1C gene. This gene controls the production of harmonin. When USH1C has a fault (mutation), it produces truncated forms of harmonin.

They injected the mice, which had been genetically engineered to have Usher syndrome, with the genetic patch. Initially, they all grew up with no balance problems and reasonable hearing. This went on for a couple of months; their hearing was near-normal in the lower frequencies.

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Tiny Genetic Patch Stops Deafness

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Females Lot13 – Video


Females Lot13
Injemira Beef Genetics 42nd Annual Production Sale Thursday 21st February 2013

By: StudLiveStockSales

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Females Lot13 - Video

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Females Lot15 – Video


Females Lot15
Injemira Beef Genetics 42nd Annual Production Sale Thursday 21st February 2013

By: StudLiveStockSales

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Females Lot15 - Video

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Females Lot16 – Video


Females Lot16
Injemira Beef Genetics 42nd Annual Production Sale Thursday 21st February 2013

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Females Lot16 - Video

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Females Lot17 – Video


Females Lot17
Injemira Beef Genetics 42nd Annual Production Sale Thursday 21st February 2013

By: StudLiveStockSales

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Females Lot17 - Video

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Females Lot18 – Video


Females Lot18
Injemira Beef Genetics 42nd Annual Production Sale Thursday 21st February 2013

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French Bulldog Puppies for Sale in Los Angeles Area for Valentines Day – Video


French Bulldog Puppies for Sale in Los Angeles Area for Valentines Day
Visit our site http://www.FrenchBulldogsla.com for more details about our breeding program. These gorgeous babies are up for grabs! Dr. Marika Zoll is passionate about healthy breeding and prides in her knowledge of genetics and dog training. Give a call NOW to be at the front of the line. 805-876-5000

By: Marika Zoll

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French Bulldog Puppies for Sale in Los Angeles Area for Valentines Day - Video

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The Diagnosis – Video


The Diagnosis
MS - Multiple sclerosis (MS), also known as "disseminated sclerosis" or "encephalomyelitis disseminata", is an inflammatory disease in which the fatty myelin sheaths around the axons of the brain and spinal cord are damaged, leading to demyelination and scarring as well as a broad spectrum of signs and symptoms. [1] Disease onset usually occurs in young adults, and it is more common in women. [1] It has a prevalence that ranges between 2 and 150 per 100000. [2] MS was first described in 1868 by Jean-Martin Charcot. [3] MS affects the ability of nerve cells in the brain and spinal cord to communicate with each other effectively. Nerve cells communicate by sending electrical signals called action potentials down long fibers called axons, which are contained within an insulating substance called myelin. In MS, the body #39;s own immune system attacks and damages the myelin. When myelin is lost, the axons can no longer effectively conduct signals. [4] The name multiple sclerosis refers to scars (scleroses mdash;better known as plaques or lesions) particularly in the white matter of the brain and spinal cord, which is mainly composed of myelin. [3] Although much is known about the mechanisms involved in the disease process, the cause remains unknown. Theories include genetics or infections. Different environmental risk factors have also been found. [4][5] Almost any neurological symptom can appear with the disease, and often progresses to physical and cognitive disability. [4] MS takes ...

By: AhdawiiTV

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The Diagnosis - Video

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LASER GENETICS ND,3 x50 – Video


LASER GENETICS ND,3 x50
EDW MBORITE NA TO PARAGILETE cgi.ebay.co.uk

By: erison bmx

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Former Vice President Al Gore: Six Drivers of Global Change – Video


Former Vice President Al Gore: Six Drivers of Global Change
92yamericanconversation.org | Former Vice President Al Gore spoke about his new book, The Future Six Drivers of Global Change, with Charlie Rose here at 92y last week. In this clip, Gore tells us what he wants us to understand about the future. "There #39;s never been a time in human history when we #39;ve had so many truly revolutionary changes going on simultaneously." Gore focuses on the revolution in genetics, the digital revolution, economic globalization and the rise of countries like China. What do you think are the most important drivers of the future?

By: 92ndStreetY

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Former Vice President Al Gore: Six Drivers of Global Change - Video

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