Public release date: 13-Jan-2013 [ | E-mail | Share ]

Contact: Karen Kreeger karen.kreeger@uphs.upenn.edu 215-349-5658 University of Pennsylvania School of Medicine

PHILADELPHIA - It is perhaps impossible to overstate the importance of the tumor suppressor gene p53. It is the single most frequently mutated gene in human tumors. p53 keeps pre-cancerous cells in check by causing cells, among other things, to become senescent aging at the cellular level. Loss of p53 causes cells to ignore the cellular signals that would normally make mutant or damaged cells die or stop growing.

In short, the p53 pathway is an obvious and attractive target for drug developers. But that strategy has so far proven difficult, as most p53 regulatory proteins operate via protein-protein interactions, which make for poor drug targets, as opposed to ones based on enzymes.

Now, a team of researchers from the Perelman School of Medicine, University of Pennsylvania, has identified a class of p53 target genes and regulatory molecules that represent more promising therapeutic candidates.

As Xiaolu Yang, PhD, professor of Cancer Biology and investigator in Penn's Abramson Family Cancer Research Institute, and his team describe in an advance online Nature publication, p53 participates in a molecular feedback circuit with malic enzymes, thereby showing that p53 activity is also involved in regulating metabolism.(The Yang lab identified p53's role in glucose metabolism in the past.)

The new findings, Yang says, suggest that p53 acts as a molecular sensor of metabolic stress and explains how metabolic stress can lead to senescence in cells.

"We uncovered an important regulatory mechanism for p53 as well as an effector mechanism for p53," Yang says.

Significantly, the findings also identify malic enzymes as novel and potentially useful pharmaceutical targets for anticancer therapy, as well as possible mediators of the normal aging process though neither possibility was actually addressed in the current study.

As cells become damaged and precancerous, the p53 protein prevents those cells from continuing towards becoming tumors by causing the cells to senesce. Metabolic cues also regulate senescence, but the molecular relays coupling those two processes -- senescence and metabolism -- remained unknown.

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Cancer suppressor gene links metabolism with cellular aging

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7th Grade Science Project Genetic Engineering Hour 6 Mrs. Lindahl
Hi! I #39;m really hungry right now. Haha.

By: Annie Ross

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7th Grade Science Project Genetic Engineering Hour 6 Mrs. Lindahl - Video

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7th Grade Science Project on Genetic Engineering Mrs Lindahl Hour 6
Sorry. My brothers are really immature. :^)

By: Annie Ross

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7th Grade Science Project on Genetic Engineering Mrs Lindahl Hour 6 - Video

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LANSING, Mich., Jan. 14, 2013 (GLOBE NEWSWIRE) -- Kraig Biocraft Laboratories, Inc. (KBLB) (the "Company" or "Kraig") announced that researchers, working pursuant to Kraig's collaborative research program, utilizing customized spider silk genetic engineering sequences, succeeded in creating a new type of recombinant spider silk, which the Company is designating as "Big Red."

The "Big Red" silk is currently being spun within the laboratory by transgenicly modified silkworms.

"'Big Red' is a composite fiber," said Company CEO, Kim Thompson. "This new type of fiber was designed to be a combination of spider silk proteins, silkworm silk proteins and protein from an unrelated species. From a genetic perspective, what significantly differentiates this material from our Monster Silk(TM) is the unique spider silk genetic sequence that we used, which we designed to increase strength to weight ratios. Another important difference is the incorporation of a unique protein, which gives the new fiber its designation as 'red.'

"The design for 'Big Red' derived from what we learned about the mechanical characteristics of recombinant spider silk fibers from our work with Monster Silk(TM)," continued Thompson. "Specifically, the new fiber was designed to place more emphasis on tensile strength and slightly less emphasis on elongation. We anticipate that 'Big Red' will be a powerful arrow in our quiver as we move to commercialize Monster Silk(TM) and the Company is hopeful that this new material will follow it in the commercialization pipeline. In my view, the creation of Big Red demonstrates the power of our technology to continue to develop new and exciting materials."

The "Big Red" name comes in part from the fact that the fibers have a slight red cast. Under UV light, the new fibers actually glow bright red.

Thompson further stated, "The successful creation of these new materials once again validates our scientific models. Based upon the observed levels of color expression and the nature of the spider silk genetic configurations used in its creation, the hope is that it will find its own significant niche in the technical textiles marketplace. Preparation for mechanical testing of the new fiber is currently taking place."

About Kraig Biocraft Laboratories, Inc.

Kraig Biocraft Laboratories, Inc. (www.KraigLabs.com) is a fully reporting biotechnology company that has achieved a series of scientific breakthroughs in the area of spider silk technology with implications for the global textile industry.

Cautionary Statement Regarding Forward Looking Information

Statements in this press release about the Company's future and expectations other than historical facts are "forward-looking statements." These statements are made on the basis of management's current views and assumptions. As a result, there can be no assurance that management's expectations will necessarily come to pass. These forward-looking statements generally can be identified by phrases such as "believes," "plans," "expects," "anticipates," "foresees," "estimated," "hopes," "develops," "researching," "research," "potential," "could" or other words or phrases of similar import. Similarly, statements in this release that describe the Company's business strategy, outlook, objectives, plans, intentions or goals should all be considered forward-looking statements. All such forward-looking statements are subject to certain risks and uncertainties that could cause actual results to differ materially from those in forward-looking statements. Management cautions that its ability to further its research, and create commercially-viable products may be affected by the competitive environment, the Company's financial condition and its ability to raise sufficient capital to meet the financial obligations of its business plan and to fund its continuing operations.

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Kraig Biocraft Laboratories Announces the Creation of New Recombinant Spider Silks

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DUBLIN--(BUSINESS WIRE)--

Research and Markets (http://www.researchandmarkets.com/research/ft27lp/animal) has announced the addition of Jain PharmaBiotech's new report "Animal Biotechnology - Technologies, Markets and Companies" to their offering.

This report describes and evaluates animal biotechnology and its application in veterinary medicine and pharmaceuticals as well as improvement in food production. Knowledge of animal genetics is important in the application of biotechnology to manage genetic disorders and improve animal breeding. Genomics, proteomics and bioinformatics are also being applied to animal biotechnology.

Transgenic technologies are used for improving milk production and the meat in farm animals as well as for creating models of human diseases. Transgenic animals are used for the production of proteins for human medical use. Biotechnology is applied to facilitate xenotransplantation from animals to humans. Genetic engineering is done in farm animals and nuclear transfer technology has become an important and preferred method for cloning animals.There is discussion of in vitro meat production by culture

Biotechnology has potential applications in the management of several animal diseases such as foot-and-mouth disease, classical swine fever, avian flu and bovine spongiform encephalopathy. The most important biotechnology-based products consist of vaccines, particularly genetically engineered or DNA vaccines. Gene therapy for diseases of pet animals is a fast developing area because many of the technologies used in clinical trials humans were developed in animals and many of the diseases of cats and dogs are similar to those in humans.RNA interference technology is now being applied for research in veterinary medicine

Molecular diagnosis is assuming an important place in veterinary practice. Polymerase chain reaction and its modifications are considered to be important. Fluorescent in situ hybridization and enzyme-linked immunosorbent assays are also widely used. Newer biochip-based technologies and biosensors are also finding their way in veterinary diagnostics.

Biotechnology products are approved by the Center for Veterinary Medicine of the FDA. Regulatory issues relevant to animal biotechnology are described.

Approximately 110 companies have been identified to be involved in animal biotechnology and are profiled in the report. These are a mix of animal healthcare companies and biotechnology companies. Top companies in this area are identified and ranked. Information is given about the research activities of 11 veterinary and livestock research institutes. Important 108 collaborations in this area are shown.

Share of biotechnology-based products and services in 2012 is analyzed and the market is projected to 2022.

The text is supplemented with 34 tables and 5 figures.Selected 250 references from the literature are appended.

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Research and Markets: 2013 Animal Biotechnology - Technologies, Markets and Companies

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By Prachiti Dalvi

Structure of Codeine

Codeine is an opioid pain medication; but if you are a poor metabolizer of a particular enzyme (CYP2D6), you will experience no pain relief from this drug. However, if your doctor could administer something called pharmacogenetic testing, she would know to simply give you morphine (an active metabolite of codeine) instead. For now, this kind of testing isnt available.

Mary Relling, PharmD

Mary V. Relling, PharmD, the Chair of Pharmaceutical Sciences at St. Judes Children Hospital spoke about the need to implement pharmacogenetic testingon Thursday, January 10. A number of tests have recently emerged that are ready for prime time. When we know that some drugs may have adverse effects for people with particular genetic phenotypes, it is unethical to prescribe these drugs without knowing the patients genetic status.

However, Relling said there are a number of barriers to integrating pharmacogenetic tests into clinical care: fragmentation of our healthcare system, a focus on sick-care rather than disease prevention, a lack of evidence for clinical utility or cost-effectiveness, complex underlying lab results, and a lack of a centralized system for recording patient information.

The best way to break through these barriers is to conduct testing preemptively, Relling said. We can simply take drop of blood when the baby is born and run genetic tests. Genetic tests are lifetime results. It makes sense to have it in the background, just as we know a patients age, weight, sex, etc., Relling said. The barriers discussed above can be avoided to a certain extent at St. Judes because they have adopted a team approach to patient care and a 100% electronic system for recording patient records.

The growing affordability of genotyping makes using preemptive pharmacogenetic testing more feasible, she said. The cost of sequencing one or two genes in the past will now produce results for 225 genes. Two years ago, theClinical Pharmacogenetics Implementation Consortium (CPIC)studied how tomigrate pharmacogenetic testing from the laboratory into routine patient care. They looked for gene-drug pairs associated with potential risks oflife-threatening toxicity, serious adverse effects, or lack of effectiveness.Eleven of the genes CPIC determined met the threshold for high-risk were found to have profound effects on 33 drugs.

Relling said approximately 48% of patients receiving drugs at St. Judes received orders for at least one of those pharmacogenetically high-risk medications.

She said the question now is how to usegenetic test results rather than whether a genetic test should be ordered. In the coming years, we will have to address how to maintain the fine balance of providing the clinician with enough information to treat the patient and overwhelming the patient with genetic testing results that are difficult to interpret.

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A Call for Action: Genetic Testing Before Prescriptions

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Bikini Bottom Genetics #5.17
Bikini Bottom Genetics #5.17

By: MrGarrettbenjamin

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Bikini Bottom Genetics #5.17 - Video

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My Slideshow querkle tga genetics
week 6

By: jeffry blodem

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My Slideshow querkle tga genetics - Video

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Genetics Problems (Monohybrid) #5.21
Genetics Problems (Monohybrid) #5.21

By: MrGarrettbenjamin

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Genetics Problems (Monohybrid) #5.21 - Video

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Uno Lady- Yellow Mustard Submarine
Video recorded and edited by Carmen Navis. Yellow Mustard Submarine written and recorded by Uno Lady. From the 2009 tape release, I really like genetics but I #39;d rather have a good time. Video from Tower 2012 bus tour to Detroit, MI and the Flower Shop in Chicago, IL. http://www.unolady.com

By: TheUnoLady

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Uno Lady- Yellow Mustard Submarine - Video

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Study Guide Genetics Mitosis Meiosis #5.25
Study Guide Genetics Mitosis Meiosis #5.25

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Study Guide Genetics Mitosis Meiosis #5.25 - Video

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MaddFarmer Genetics Urkle Queen
Grown by ~H~

By: Dublin Skunkfiend

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MaddFarmer Genetics Urkle Queen - Video

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Yoga Teacher Gets Double Mastectomy to Avoid Breast Cancer | Inner Visions, Outer Triumphs
http://www.stoneweardesigns.com. Yoga teacher, long-time yoga practitioner, mother, wife, former corporate employee, Emily Goble tested positive for both breast cancer and ovarian cancer genetics. Because her mother has struggled with eight different types of cancer over 25 years and Goble was 87% likely to get breast cancer and 90% for ovarian, she voluntarily opted for a double mastectomy and will soon be undergoing a voluntary hysterectomy. Wow. Check out the Inner Visions, Outer Triumphs video for more on her extraordinary journey. The article below focuses on Goble #39;s yoga teaching and the support her students offered her through the process. Read more at http://www.livestonewear.com

By: StonewearDesigns

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Yoga Teacher Gets Double Mastectomy to Avoid Breast Cancer | Inner Visions, Outer Triumphs - Video

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Copy of MaddFarmer Genetics Urkle Queen
Grown by ~H~

By: Dublin Skunkfiend

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Copy of MaddFarmer Genetics Urkle Queen - Video

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Fallout 3 Awesome Adventures Part 1: Black Dad
I find out about the ways of genetics of birth and have fun doing it! Along with some physics and bad parenting skills so enjoy!

By: AwesomeMat64

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Fallout 3 Awesome Adventures Part 1: Black Dad - Video

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Apa itu Fastabiqul Khairat?
soundtrack : First Breath After Coma - Explosion In The Sky credit to seniors involved : Bro Firdaus ASIS 3rd year - Ecology Biodiversity Bro Hanif ASIS 3rd year - Microbiology Sis Andi Nur Hazirah ASIS 3rd year - Biohealth Sis Fatimah Zahra SEMPIS 1st year - Genetics Molecular Biology

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Apa itu Fastabiqul Khairat? - Video

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Christiana Care: Cancer Genetic Counseling
Knowing the risks for cancer in your family may help you to avoid cancer or to find it early, when it is most curable. The genetic risk assessment program at Christiana Care #39;s Helen F. Graham Cancer Center can help identify your risks for hereditary cancer based on family history and genetics, as well as additional personal and environmental factors.

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Christiana Care: Cancer Genetic Counseling - Video

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Public release date: 13-Jan-2013 [ | E-mail | Share ]

Contact: Kathy Beal kbeal@acmg.net 301-238-4582 American College of Medical Genetics

Health, science and genetics reporters are invited to register now for the American College of Medical Genetics and Genomics (ACMG) Annual Clinical Genetics Meeting, March 19-23, 2013 at the Phoenix Convention Center. From Genetic Testing to Whole Genome/Exome Sequencing, the focus of the ACMG Meeting is on the actual practice of genetics and genomics in healthcare today and in the future. The conference will showcase the latest breakthroughs in genetics research and its practical applications to medical practice and public health. The ACMG Annual Meeting attracts medical and scientific leaders from around the world who are working to apply research in genetics and the human genome to the diagnosis, management, treatment and prevention of genetic conditions and rare and common diseases.

From the cytogenomics of cancer to neurogenetics; from noninvasive prenatal diagnosis to whole genome analysis; and from medical reimbursement issues to next generation sequencing, reporters will hear about the latest research; have the opportunity to interact with doctors, laboratory professionals and genetic counselors about what is happening right now in genetics and genomics; and view the latest products available in the extensive exhibit hall.

Topics range from common conditions to rare diseases. Sessions include information of interest to the general public, to health professionals and to the industry/trade.

The ACMG Meeting is the genetics meeting most focused on the practical applications of genetic discoveries in a clinical setting.

###

To see the complete program, visit http://www.acmgmeeting.net.

Photo/TV Opportunity: The ACMG Foundation will present bicycles to local children with rare genetic diseases at the Annual Day of Caring at the Annual Meeting in Phoenix.

To receive a complimentary media registration, contact Kathy Ridgely Beal, MBA at kbeal@acmg.net for the Press Registration Access Code.

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ACMG 2013 Clinical Genetics Meeting -- Complimentary press registration is now open

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BOCA RATON, FL--(Marketwire - Jan 14, 2013) - Atossa Genetics ( NASDAQ : ATOS ), the Breast Health Company, based in Seattle, Washington, and Clarity Women's Health (a division of Diagnostic Test Group, LLC) of Boca Raton, Florida, announced today the launch of the ForeCYTE Breast Health Test at Clarity's national sales meeting, held on January 10-11th, 2013, in Boca Raton, Florida. The patented ForeCYTE Breast Health Test is designed for the early detection of precancerous breast conditions and the determination of the future risk of breast cancer, using a clinically validated algorithm including family history, personal reproductive history and breast cytopathology. The ForeCYTE Test, which uses the patented, FDA-cleared MASCT Breast Health System to painlessly collect a tiny sample of nipple ductal fluid, is designed to be performed at the point of care in a non-invasive and highly sensitive manner.

"Clarity Women's Health brings tremendous relationships with its clients driven by highly skilled technical support and customer service teams. I believe we have a strong national launch strategy working with the Clarity team and we anticipate rapid adoption as physicians' access to the ForeCYTE test is expanded," said Chris Destro, Vice President of Sales and Marketing, Atossa Genetics, Inc. "The passion and commitment of the entire team at Clarity Women's Health to make a difference in the current paradigm of breast health is palpable."

"The ForeCYTE Breast Health Test is the cornerstone of our new division, Clarity Women's Health," stated Daniel Lger, Vice President of Sales and Marketing, Diagnostic Test Group, LLC. "This product is targeted for over 110 million women between the ages of 18 and 73 in the U.S. who can now obtain a simple test in their physician's office and learn their future risk of breast cancer up to eight years before mammography can pick it up. This kind of advanced information was created for cervical cancer by the Pap smear and was responsible for the 75% reduction in the incidence of cervical cancer. The ForeCYTE Breast Health Test has the potential to do the same for breast cancer."

For more information, please click the following link to view a video interview with Christopher Destro, VP of Sales and Marketing of Atossa genetics discussing aspects of this press release in more detail: http://client.irwebkit.com/AtossaGenetics/media. You may also sign up to receive automatic email News Alert updates there.

About Atossa Genetics, Inc.

Atossa Genetics, Inc. ( NASDAQ : ATOS ), The Breast Health Company, is based in Seattle, WA, and is focused on preventing breast cancer through the commercialization of patented, FDA-cleared diagnostic medical devices and patented, laboratory developed tests that can detect precursors to breast cancer up to eight years before mammography, and through research and development that will permit it to commercialize treatments for pre-cancerous lesions.

About Clarity Women's Health

Clarity Women's Health is a division of Diagnostic Test Group, LLC in Boca Raton, FL, and is a sales, marketing and branding company focused on the sale and distribution of its own Clarity brand of rapid and diagnostic tests, molecular tests, and diagnostic equipment utilized in physicians' offices, clinics, labs, urgent care centers and hospitals. DTG offers one of the largest lines of diagnostic tests in the industry supported by its own national sales force combined with in-house 24 hour customer service and tech support. Clarity products are available at most of the recognized national distributors. The ForeCYTE Breast Health System will form the cornerstone of its newly created division, Clarity Women's Health.

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Atossa Genetics and Clarity Women's Health Announce U.S. Launch of the ForeCYTE Breast Health Test

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C5 Incomplete Spinal Cord Injury: 6 months post and taking steps

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C5 Incomplete Spinal Cord Injury: 6 months post and taking steps - Video

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Breaking Through the CSPG Roadblock. Spinal Cord Injury in Nepal.
Drs. Ravi Bellamkonda and Jerry Silver, along with Nepalese PT Damodar Thapa, in a Question and Answer session following their presentations.

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Breaking Through the CSPG Roadblock. Spinal Cord Injury in Nepal. - Video

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"Regenerating Functions that Mediate Motor Function after Spinal Cord Injury" - Dr. Oswald Steward
Dr. Steward discusses the discovery and progress of pTen deletion and related therapies.

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Genetic engineering human-animal genetic hybrid or chimera
Genetic engineering human-animal genetic hybrid or chimera Trans-Humanism Mixing Human DNA with Animal DNA. Tom Horn WARNING of disaster BREAKING NEWS ALERT WARNING TO HUMAN RACE human-animal genetic hybrid or chimeras full grown thousands of labs worldwide with animal human experiments this is sick and funded by the world Governments. Do your research what the UN is preparing to do between now and 2025 worldwide. We are in the end times last days the medical field is playing god DANGEREOUS times we are living Part Human part animal genetic hybrids A parahuman or para-human is a human-animal Genetic engineering human-animal genetic hybrid or chimera hybrid or chimera. Scientists have done extensive research into the mixing of genes or cells from different species, eg adding human (and other animal) genes to bacteria and farm animals to mass-produce insulin and spider silk proteins, and introducing human cells into mouse embryos. Parahumans have been referred to as "human-animal hybrids" in a vernacular sense that also encompasses human-animal chimeras. The term parahuman is not used in scientific publications. The term is sometimes used to sensationalize research that involves mixing biological materials from humans and other species. It was used in a National Geographic article to describe an experiment in 2003, during which Chinese scientists at the Shanghai Second Medical University successfully fused human cells with rabbit eggs. According to Daily Mail, as of 2011 ...

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Genetic engineering human-animal genetic hybrid or chimera - Video

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The Youth Pill
Science for the Public, September 10, 2010. David Stipp, author of The Youth Pill: Scientists at the Brink of an Anti-Aging Revolution. discusses how scientific and medical researchers are addressing the issue of aging. As modern populations live longer, it is necessary to understand both the aging process itself and the potential for greater longevity with good health. Mr. Stipp makes a sharp distinction between bogus claims of an easy way to obtain longevity and the very serious research in genetics and other fields suggesting the possibility of extending productive life. He offers a very clear analysis of the scientific data on aging, and he argues the case for more research and better public information on this issue.

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The Youth Pill - Video

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Minecraft Lets Play - Episode 25 - MINECRAFT COW GENETICS GONE WRONG
Please leave a like! It helps out a lot! 🙂 Minecraft, The game where cows have sex and pop out a horrible genetically wrong cow.. Enjoy!! 😀 Facebook Page: http://www.facebook.com

By: JJGaming000

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Minecraft Lets Play - Episode 25 - MINECRAFT COW GENETICS GONE WRONG - Video

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