Welcome to the HMGC
Howard Jacob, Ph.D., director and founder of MCW #39;s personalized medicine program at the Human and Molecular Genetics Center, explains personalized medicine and how it will change the face of health care

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PART 2 PURPLE OG #18 (DNA Genetics) Voyagers Coffeeshop - Amsterdam Weed Review
^ CLICK FOR MORE INFO ^ PLEASE LIKE AND SHARE THIS VIDEO! andrew.pyrah.net Check out my new website - http - Your Site for Amsterdam Coffeeshops, Cannabis Information and Reviews! Thanks for watching! COMMENT and LIKE if you enjoyed the video and SUBSCRIBE to see my new videos as they are released. Need a flight or a hotel in Amsterdam? andrew.pyrah.net HELP SUPPORT THIS CHANNEL Shop Online at EveryoneDoesIt (EDIT) - edit.pyrah.net - Bongs, pipes and more! Or at Weed World - http - Home of Weed World Magazine! Donate via PayPal - http://www.paypal.com - Thanks! FACEBOOK - facebook.com TWITTER - twitter.com @andrewpyrah #PeaceAndPot #AndrewPyrah DAILYBOOTH (Photos) - dailybooth.com MUSIC Intro Music is Bun Up The Sess - youtu.be by Oneroot Freeman - youtube.com Other Music by Kevin MacLeod - incompetech.com Used with permission and thanks to all artists. SPECIAL THANKS TO The Wickit Wand - http Beeline Hemp Wick - TheBeelineStore.com THANKS FOR WATCHING! PEACE AND POT! Head over to http to see more!

By: Andrew Pyrah

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PART 2 PURPLE OG #18 (DNA Genetics) Voyagers Coffeeshop - Amsterdam Weed Review - Video

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Its hard to get straightforward health guidance from personal genome tests, which are banned in some places. But one way to make them more meaningful is to let more people buy them.

It was easy to send my spit to 23andMe, a personal genetics company based in Mountain View, California. I filled the tube that came by mail with a few milliliters of saliva, mixed in the preservative solution, and screwed on the cap, and my sample was ready to be mailed. Soon I would know my risks for Alzheimers, breast cancer, and obesity, and Id have an idea what medications I should avoid.

Well, not exactly. As in most of human genetics, whats tricky about consumer-friendly tests is interpreting the significance of DNA variation. A couple of weeks after shipping off my tube, I got an e-mail notice that my results were on 23andMes website. While it was fun to click through my ancestry reports, I was less compelled by the analysis of the genetic traits that could influence my health.

The biggest disease risk in my report? I have a 5.2 percent chance of developing restless leg syndrome later in life24 percent greater than the average person, who has a 4.2 percent risk. My risk for Alzheimers is slightly lower than average and my risk for obesity is typical. But these conclusions are not particularly meaningful. New studies could uncover variants in my genome that carry a significant risk for dementia later in life. And for obesity, genetics can be overshadowed by lifestyle.

The results did contain some useful information, however. For example, my genome carries signs that I have an above-average sensitivity to a common blood thinner. Currently, I dont need such a drug, but if that changessay, if I suffer a heart attackthen this knowledge could be critical in helping a physician determine the proper dose of a potentially life-saving medication. I also found motivation to switch to decaffeinated coffeemy report says I am a slow caffeine metabolizer, which is associated with a risk of heart attacks for multi-cup-a-day users like me.

23andMe Personal Genome Service

In some ways, I was lucky that I found nothing monumental in my report. About 40 to 50 percent of customers end up with results like yoursthey dont have anything that jumps out very strongly, says Joanna Mountain, senior director of research at 23andMe. But for many, the results are potentially more significant. For example, for macular degeneration, the risks [that are indicated in the reports] range from 0.1 percent up to 74 percent, Mountain says. For heart disease, theres a big range10 to 50 percent.

It can be difficult for most people to understand what these ranges mean, though. And for now, its not clear how receptive the medical community is to helping. Ive had patients bring me these reports, and I dont spend a lot of time reviewing the results because this is not a test I would have ordered, says Sharon Plon, a geneticist and physician-scientist at Baylor College of Medicine in Houston. Whats missing is proof that these tests can inform and improve patient care, she says: Physicians are going to shy away from using them unless they become part of evidence-based medicine.

Typically, personal genetics companies like 23andMe determine which particular DNA base pairs each customer has at places in the human genome that are known to vary from person to person. The companies then interpret the results of scientific studies to tell customers what their results mean. The tests are sold directly to consumers for as little as a few hundred dollars, without the involvement of a health-care provider. In 2010, the FDA sent letters to several companies warning them that their products were considered medical devices subject to regulation, although exactly how the oversight would happen still hasnt been firmly established. That same year, the Government Accountability Office sent samples to four companies and got conflicting results.

Because interpreting the results is so uncertain and the relationship between genetics and disease risk is sometimes weak in the first place, some critics oppose selling these tests directly to consumers. Such sales are restricted in some countries, such as France, and in a few U.S. states, including New York and Maryland. The American College of Medical Genetics and Genomics stance is that the tests should be taken with guidance from an expert who can assess the validity of the results and explain the actions that could be taken in response, says executive director Michael Watson. New studies on the connection between DNA and disease or drug response are published every week. Some of these studies establish a previously unknown link; others may add more weight to a known association; yet others may contradict or disprove what was once thought to be meaningful. The results of many of these tests are very complex, says Plon.

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Fiscal Game! SUPER Soldier NIGHTMARE! Violent crime worse in Britain than US
My commentary on the Fiscal cliff foolishness, the ethics of military forces using gene therapy to create mutant soldiers, Japan nationalizing factories and more. DEMCAD2: Emergency Preparation Items Should Be Accessible http://www.youtube.com NonfictionTube http://www.youtube.com Senate-Passed Deal Means Higher Tax on 77% of Households http://www.bloomberg.com CBO Estimates "Obama Tax Cut" To Add $4 Trillion To Deficit Over Next Decade http://www.zerohedge.com Pope #39;s new year address deplores rampant capitalism http://www.bbc.co.uk Japan plans #39;nationalisation #39; of factories to save industry http://www.telegraph.co.uk Violent crime worse in Britain than in US http://www.dailymail.co.uk US on Pace for Slowest Decade of Population Growth Since 1930s http://www.bloomberg.com #39;Tsunami bomb #39; tested off New Zealand coast http://www.telegraph.co.uk Military Must Prep Now for #39;Mutant #39; Future, Researchers Warn http://www.wired.com

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AUSTRALIAN researchers have found a ''genetic switch'' that could open up new treatments for breast cancer.

The switch allows scientists to change breast cancer cells and make them more responsive to treatments such as anti-oestrogen therapies.

Outlined in the journal PLOS Biology, researchers from the Garvan Institute of Medical Research in Sydney found the molecule, known as ELF5, can turn genes on or off.

By manipulating it, the breast cancer cell's sensitivity to anti-oestrogen drugs used to treat breast cancer can be increased.

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''We've made a discovery that concerns the basic biology of breast cancer,'' said Chris Ormandy from the Garvan Institute. ''ELF5 determines whether cells will respond to oestrogen therapy or not.''

Oestrogen plays a key role in breast cancers. Women who do not experience much oestrogen, either because they start menstruating later in life or begin menopause early, have a lower risk of breast cancer.

Led by Professor Ormandy in collaboration with colleagues Maria Kalyga and David Gallego-Ortega, the finding establishes for the first time that there is a link between the molecule and breast cancer.

Found in all breast cells, the molecule was discovered by Professor Ormandy's team in 1999. In 2008 his group showed it triggered milk production in women.

Made with British researchers, the latest discovery raises the potential for drugs designed to reduce the amount of the molecule in those cancer cells dependent on ELF5 for proliferation. Further research could also reduce the incidence of patients undergoing ineffective treatment.

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'Gene switch' offers hope in breast cancer fight

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Itamar Kahn - New View of Brain Function - Technion Lecture
Prof. Itamar Kahn, Rappaport Faculty of Medicine, Technion. "A New View of Brain Funtion: Integration of Genetic Engineering and High-resolution fMRI. Lecture presented on March 7, 2012. #1508; #1512; #1493; #1508; #39; #1488; #1497; #1514; #1502; #1512; #1511; #1488; #1492; #1503;

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Muscle Gaining Secrets Overview - FREE 30 Days Online Coaching
tinyurl.com Follow The Link To Go From Skinny To Jacked In 90 Days Flat! Muscle Gaining Secrets 2.0 is the skinny guys bible and is jam packed with tricks, tips and advanced techniques that most people have no clue about. No overly complicated scientific formulas or insider jargon that requires a degree in advanced physiology. No nonsense, no filler, no fluff; just the hard hitting, scientific truth about exactly what you HAVE to do to build muscle faster than ever before. If you #39;re sick and tired of being skinny, fat and weak this is the workout program for you. tinyurl.com Frequently Asked Questions: Q: What equipment do I need can I train at home? Barbells and dumbbells. A basic home gym will cover you as there are no machines or fancy gym equipment required. A chin up bar and a power rack would also be a huge plus. But if you don #39;t have these things I #39;ll show you a few substitutions. Q: How soon can I expect to see results and how much muscle can I build using this program? You should notice results within the first two weeks. After a month you #39;ll have made some noticeable changes, and by two months you #39;ll see a big difference. How big you get is ultimately determined by your genetics. tinyurl.com Q: Am I going to have to spend countless hours in the gym every week? Absolutely not. You #39;ll only have to train four days per week and you #39;ll be in and out of the gym in just 45 minutes! Q: What if I don #39;t want to get big like a bodybuilder? Can I still use your program ...

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Goodbye, Rita. (Music by Gordon Jenkins)
Rita Levi-Montalcini (22 April 1909 -- 30 December 2012), Knight Grand Cross, was an Italian neurologist who, together with colleague Stanley Cohen, received the 1986 Nobel Prize in Physiology or Medicine for their discovery of nerve growth factor (NGF). From 2001 until her death she also served in the Italian Senate as a Senator for Life. Rita Levi-Montalcini had been the oldest living Nobel laureate and the first ever to reach a 100th birthday. On 22 April 2009, she was feted with a 100th birthday party at Rome #39;s city hall. Born on 22 April 1909 in Turin to an Italian Jewish family, together with her twin sister Paola she was the youngest of four children. Her parents were Adamo Levi, an electrical engineer and mathematician, and Adele Montalcini, a painter. In her teenage years, she considered becoming a writer and admired Swedish writer Selma Lagerlöf. Adamo discouraged his children from attending college as he feared it would disrupt their lives as wives and mothers but he eventually supported Levi-Montalcini #39;s aspirations to become a doctor anyway. Levi-Montalcini decided to attend University of Turin Medical School after seeing a close family friend die of cancer. While attending, she was taught by neurohistologist Giuseppe Levi who introduced her to the developing nervous system. After graduating in 1936, she went to work as Giuseppe Levi #39;s assistant, but her academic career was cut short by Benito Mussolini #39;s 1938 Manifesto of Race and the subsequent introduction ...

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Hemorrhoid No More Review - Natural Cure
http://www.digitalreviewz.com Check out this link for more info on the Hemorrhoid No More product. Cure your hemorrhoids naturally with this effective program. Jessica Wright has created an all natural program that can help you relieve and cure your hemorrhoid problems forever. Her 5 step holistic plan is designed to relieve and eliminate all types of hemorrhoids. Having purchased and used this system, I can say with absolute certainty that it works! It works because instead of fixing the symptoms, you learn how to treat the source of the problem. Once you gain insight into how simple this is to do, you #39;ll never have to live with this embarrassing problem again. Some of the things you #39;ll learn in her program include: bull; Why hemorrhoids are nothing to be ashamed of bull; What hemorrhoids are and an explanation of the different types? bull; Discovering which type you have bull; Things that may be causing your hemorrhoids including dietary choices, Candida overgrowth, obesity, pregnancy, straining, constipation, genetics and more. bull; Diagnosing and treating your hemorrhoids the conventional way bull; Discovering whether you are at risk for hemorrhoids bull; An effective 48 hour treatment plan bull; Simple recipes to ease the pain bull; A 5 step holistic plan for eliminating all types of hemorrhoids This guide is a must have for anyone who suffers from this condition. Read a detailed description of the product at http://www.digitalreviewz.com

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MADISON, N.J., Dec. 31, 2012 /PRNewswire/ -- Quest Diagnostics (DGX), the world's leading provider of diagnostic information services, announced today that it has sold substantially all of the assets of itsOralDNA Labs salivary-diagnostics business to Access Genetics, a leading clinical laboratory with advanced molecular diagnostics test development and information technology capabilities.Terms of the transaction were not disclosed.

The divestiture of OralDNA represents a step in the company's ongoing strategy to refocus its resources on its core diagnostic information services business for physicians and hospitals, drive operational excellence and restore growth.In November, the companyannounced changes to its management team and simplified its organization structurein order to concentrate onits core business.

Access Genetics has provided support and expertise for OralDNA-based testing services for dental professionals since 2008. As part of the transaction, OralDNA's testing services, now provided from a facility in Brentwood, Tennessee, will consolidate under Access Genetic'sCLIA- and CAP-certified laboratoryin Eden Prairie,Minnesota.

About Quest Diagnostics Quest Diagnostics is the world's leading provider of diagnostic information services that patients and doctors need to make better healthcare decisions. The company offers the broadest access to diagnostic information services through its network of laboratories and patient service centers, and provides interpretive consultation through its extensive medical and scientific staff. Quest Diagnostics is a pioneer in developing innovative diagnostic tests and advanced healthcare information technology solutions that help improve patient care. Additional company information is available at QuestDiagnostics.com.

Quest Diagnostics Contacts: Wendy Bost (Media): 973-520-2800 Kathleen Valentine (Investors): 973-520-2900

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CAMBRIDGE, Mass., Dec. 31, 2012 /PRNewswire/ --Metamark Genetics, Inc., a privately held, oncology-focused molecular diagnostics company, announced today that its scientific co-founder Lynda Chin, MD, has resigned from the Metamark board of directors. Dr. Chin is a leader in cancer genomics, member of the Institute of Medicine of the National Academy of Science, Scientific Director of the Institute for Applied Cancer Science, and founding Chair of the department of Genomic Medicine at MD Anderson Cancer Center. She has pioneered the use of comparative oncogenomics to discover new drug targets and diagnostics for cancer patients and is one of this nation's leading entrepreneurs. Commenting on the transition, company co-founder Kenneth E. Weg stated, "Lynda has been a visionary, leading the way to predict the prognosis of early stage cancers so that we can identify the patients who are most at risk for disease progression. We are thankful for her insight and guidance on our board." Dr. Chin stated, "I am excited by Metamark's progress, particularly its recent achievement of critical clinical and commercial milestones. This strong scientific and financial foundation will enable Metamark to impact on the enormous problem of prostate cancer management and more. I am extremely grateful to Metamark for realizing my dream of translating scientific discoveries into meaningful clinical advances for patients."

About Metamark Genetics, Inc.

Metamark is a privately held oncology company focused on the development of molecular function-based prognostic assays for early staged cancers. The MetamarkDx Prognostic Assays under development are based on Metamark's proprietary Prognosis Determinants, genes discovered through leading edge cancer research and demonstrated to play a causal role in promoting tumor progression and spread. For further information, please visit the company's website at http://www.metamarkgenetics.com.

Cautionary Note Regarding Forward-Looking Statements

This press release, and information contained on Metamark's website, contains forward-looking statements that involve substantial risks and uncertainties, including statements regarding Metamark's strategies and future plans, prospects and results. The words "anticipate," "believe," "expect," "intend," "may," "plan," and other similar expressions are intended to identify forward-looking statements, although not all forward-looking statements contain these identifying words. Metamark may not actually achieve the plans or expectations disclosed in its forward-looking statements, and you should not place undue reliance on its forward-looking statements.

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Centagen has developed a breakthrough stem cell therapy that rejuvenates a patient's own adult stem cells. The Company has found a way to expand a patients own stem cells in the lab millions of times while rejuvenating the cells. For example, a patients blood pleuropotent stem cells could be rejuvenated and expanded in the lab and then re-injected to repair and rejuvenate organs and tissues damaged by aging or disease. Centagen has announced a funding campaign at http://www.indiegogo.com/centagen for additonal research and development.

Boulder, Colorado (PRWEB) December 31, 2012

Each of us has a limited supply of the kind of stem cells needed to rebuild, repair, and rejuvenate any part of our body. As we age, the supply and healing power of our stem cells diminishes. By providing a practically unlimited supply of one's own rejuvenated stem cells, we may keep people young and healthy for well over a century. In particular, regenerating tissues and organs prepared by expanding ones own stem cells could help with Alzheimers disease, diabetes, immune senescence, damaged heart tissue, arteriosclerosis, failing kidneys, failing hearing or eyesight, osteoporosis, weak muscles, and aged skin.

The technology requires no genetic engineering of the stem cells, so the procedure is much safer than the current procedures requiring genetic tampering. Only a patients adult stem cells are used, so there are no ethical issues common with embryonic stem cell use or side effects due to tissue rejection by your immune system.

Centagen has recently opened a crowd funding bid at http://www.indiegogo.com/centagen in concert with Maximum Life foundation, whose mission is to make 100 years old the new 50.

Forward-Looking Statements for Centagen, Inc.

This press release contains several forward-looking statements within the meaning of the Private Securities Litigation Reform Act of 1995. Forward-looking statements reflect management's current expectations, as of the date of this press release, and involve certain risks and uncertainties. Forward-looking statements include statements herein with respect to the successful execution of the Company's business strategy of stem cell therapeutics. The Company's actual results could differ materially from those anticipated in these forward- looking statements as a result of various factors and the Company's further development is highly dependent on future medical and research developments and market acceptance, which is outside of its control. The Company may not update these forward-looking statements in a timely manner as conditions change.

Bryant Villeponteau, Ph.D. Centagen (877) 757-1923 Email Information

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Dr. Naina Sachdev on Nutrigenomics at The Anti-Aging Regenerative Medicine Conference Bangkok 2011
Dr. Naina speaks at The Anti-Aging Regenerative Medicine Conference (BCAARM 2011) in Bangkok, Thailand. Learn More About Dr. Naina at: http://www.nainamd.com

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Dec. 27, 2012 Researchers have uncovered a novel role of BRCA1 in regulating the survival of skin stem cells.

Our DNA, which stores our genetic information, is constantly submitted to damage. If not properly repaired, DNA damage can lead to cell death, which may in turn lead to tissue exhaustion and aging, or induce mutations resulting in uncontrolled cell proliferation and cancer. Brca1 is a key gene that mediates DNA repair. Mutations in Brca1 lead to familial and sporadic breast and ovarian cancer in humans.

In this study published in Genes and Development, researchers led by Cdric Blanpain, MD/PhD, Professor at Universit libre de Bruxelles (ULB) and WELBIO investigator, showed the critical role of Brca1 for the maintenance of hair follicle stem cells.

Peggy Sotiropoulou and colleagues showed that upon deletion of the breast cancer associated gene Brca1 in the epidermis, hair follicle cells show high levels of DNA damage and cell death, which induce hyperproliferation and finally exhaustion of hair follicle stem cells resulting in hair follicle degeneration. In contrast, the other types of stem cells located in the epidermis, which are forming the skin barrier and the sebaceous glands, are maintained and continue to function normally despite the absence of BRCA1, demonstrating the different requirement for BRCA1 in the distinct types of adult stem cells. "We were very surprised to see that distinct types of cells residing within the same tissue may exhibit such profoundly different responses to the deletion of the same, crucial gene for DNA repair gene" comments Peggy Sotiropoulou, the first author of this study.

This work is very important to understand the DNA repair mechanisms in different types of adult stem cells and at different stages of their activation. If other stem cells of the body also require BRCA1 for their survival, this result may potentially explain why Brca1 mutations in women lead preferentially to the development of only breast and ovarian cancers.

This work was supported by the FNRS, WELBIO, the program d'excellence CIBLES of Wallonia, a research grant from the Fondation Contre le Cancer, the Fondation ULB, the Fonds Yvonne Bol, and the Fonds Gaston Ithier, a starting grant of the European Research Council (ERC) and the EMBO Young Investigator Program.

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Novel role of BRCA1 in regulating the survival of skin stem cells identified

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Stem Cell Therapy at IMC Dr.Omar Gonzalez
New Project 70

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Geneticists have been asked to study the DNA of Adam Lanza, the Connecticut man whose shooting rampage killed 27 people, including an entire first grade class.

IS there an "evil" gene? A group of United States geneticists want to study Newtown school killer Adam Lanza's remains to find out.

The New York Times reports that a spokesperson at the University of Connecticut has confirmed the researchers' plans, but declined to provide any further details.

Adam Lanza, 20, shot his mother before driving to Sandy Hook Elementary School where he slaughtered 20 children and six adults. It was one of the United States' worst ever school shootings.

Speculation is rampant that the geneticists will look for mutations that may be linked with mental illnesses or associated with violent predispositions within Lanza's DNA.

It would be the first detailed study of the DNA of a mass murderer.

The search for an easy means of finding potentially "evil" people has a long and dubious history, most notably the pseudoscience of phrenology which claims to detect a criminal mindset through the shape of a skull.

The eugenics movement of a century ago insisted "evil" behaviour was inherited, leading to the sterilisation of criminals and mental patients.

However, Dr Arthur Beaudet, a genetics professor at the Baylor College of Medicine in Texas, told the newspaper: "We can't afford not to do this research".

Face of evil? Adam Lanza as a child, left, as a student in 2005 and in a more recent photograph issued by police.

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Is an 'evil gene' behind mass killings?

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Dec. 24, 2012 At least two common gene variants are linked to "clinically meaningful" differences in pain scores in children after major surgery, reports a study in the January issue of Anesthesia & Analgesia, official journal of the International Anesthesia Research Society (IARS).

"[O]ur study is highly suggestive of a genetic component in pain response among children," concludes the study by Dr Chantal Mamie and colleagues of Geneva University Hospitals, Geneva, Switzerland. But an accompanying editorial question the relevance of this and previous studies of pain-related genes for management of pain in individual patients.

Gene Variants Influence Pain Scores after Surgery

The study was designed to explore whether several "candidate" gene variants affected pain scores in a group of 168 children undergoing major surgery -- either abdominal or bone and joint operations. The children and their parents were tested for variant forms ("polymorphisms") of six different genes previously reported as having a possible impact on pain.

The genetic results were compared with the children's pain scores, as routinely monitored during the 24-hour recovery period after surgery. During that time, the children had access to patient- (or parent- or nurse-controlled) analgesia with strong opioid (morphine-related) pain relievers.

Variants of two genes were related to "clinically meaningful" increases in pain scores -- at least four "peak" scores higher than six (on a ten-point scale) during the 24 hours after surgery. After adjustment for other factors, the risk of elevated pain scores was 4.5 times higher for children with a specific variant of the gene ABCB1, which affects the transport of opioid drugs to the central nervous system.

Risk of elevated pain scores was 3.5 times higher for children with a certain variant of the gene OPRM, a key target receptor for opioid binding. The associations with ABCB1 and OPRM variants remained significant after adjustment for patterns of gene inheritance from parents. Variants of two additional genes affecting pain perception -- NTRK and COMT -- were linked to more subtle, "subclinical" effects on pain scores.

But Have No Effect on Use of Pain Medications

Surprisingly -- even though the gene variants affected pain scores -- they were unrelated to the total dosage of opioid medications used. The dosage of patient-controlled analgesia provides an important objective measure of pain and pain control after surgery.

"The present results are plausible given the known functionality of the candidate genes, and are consistent with the findings in adults," Dr Mamie and colleagues write. Although there has been a wealth of research on the genetic basis of pain in adults, the researchers add, "This first but small cohort study provides clues to further explore the genetic foundations of pediatric pain."

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Gene variants affect pain susceptibility in children

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Game Genetic engineering
You will become a laboratory worker in this Genetic engineering game. Here you will work with genes and cells. It is veryhard work, you will need your savvy. Play this game at: fungirlsgames.net

By: #1040; #1085; #1078; #1077; #1083; #1080; #1082; #1072; #1041; #1088; #1091; #1089; #1085; #1080; #1095; #1082; #1080; #1085; #1072;

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Biotechnology Activities at Genetic Engineering Research Center, FOA, CU
Biotechnology Activities at Genetic Engineering Research Center, Faculty of Agriculture, Cairo University

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Genetic Engineering of Spermidine Pathway Enhances Phytonutrients Levels
Genetic Engineering of Spermidine Pathway Enhances Phytonutrients Levels and Postharvest Life of Fruit and Delay Whole Plant Senescence

By: eBicEgypt

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