Sacral Sparing - Everything You Need To Know - Dr. Nabil Ebraheim
Educational video describing sacral sparing test for spinal cord injury. Become a friend on facebook: http://www.facebook.com Follow me on twitter: twitter.comFrom:nabilebraheimViews:0 0ratingsTime:02:03More inEducation

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Robert Hariri of Lifebank USA on cord blood and RM space - at World Cord Blood Congress 2012
Dr. Robert Hariri, President of Lifebank USA spoke at the World Cord Blood Congress 2012 on the topic, #39;Increasing cord blood presence in the regenerative medicine space. #39; World Cord Blood Congress is where private and public cord blood banks, pharma and biotechs, academia and government come to debate advances in cord blood banking and therapeutics. For more information, go to http://www.terrapinn.com/cordblood. Or, check out our blog at blogs.terrapinn.com/total-biopharma for up to date information on the stem cells, RM and cord blood banking and therapeutics sectors.From:biopharmachannelViews:0 0ratingsTime:24:11More inScience Technology

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Osmosis ATP Cell Therapy
Osmosis from SkinCare by Alana. Visit our site for latest offers, tips, and info: http://www.skincarebyalana.com Purchase Osmosis products from SkinCare by Alana, the premier online skincare retailer and spa in Orange County. The goal of Osmosis Skincare is to help restore your dermis and epidermis to their youthful healthy states for more beautiful skin. http://www.skincarebyalana.com youtu.be Purchase Osmosis products today!From:spainfo411Views:0 0ratingsTime:02:10More inHowto Style

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TORONTO, Dec. 18, 2012 /CNW/ - Dr. Tom Hudson, President and Scientific Director of the Ontario Institute for Cancer Research (OICR), today announced that scientists at the Institute have developed a new computer-based method to identify gene signatures that can serve as prognostic biomarkers for cancer. The researchers, Drs. Guanming Wu, Research Associate, and Lincoln Stein, Platform Leader and Principal Investigator, Informatics and Bio-computing Platform, used this technique to discover gene expression signatures related to survival in breast and ovarian cancers. Their study was published in the journal Genome Biology.

To find the gene signatures, Wu and Stein used a collection of algorithms to interrogate gene expression datasets from both breast and ovarian cancer patients. This involves two steps. First, one algorithm mines the data for modules of interacting genes that play a role in the disease process, independent of clinical status. Then a second algorithm scans the genomic dataset for modules that have clinical significance.

Wu and Stein's application of this method to breast cancer found a 31-gene signature that is strongly correlated with patient survival in estrogen receptor positive breast cancer. Application of the method to high-grade serous ovarian cancer discovered a 75-gene signature that is correlated with patient survival. Discovery of the gene signature for ovarian cancer fills an unmet clinical need as few prognostic signatures have been found for this disease.

"A key aspect of OICR's mission is to translate our growing understanding of the genomic alterations underlying cancers into clinically useful tools. By creating a new method able to find reliable prognostic biomarkers, we hope to enable a new paradigm of precision medicine in which treatment decisions are based on the exact nature of the patient's disease," says Stein.

Biomarkers are biological entities such as genes and proteins that indicate the presence and state of a disease. Testing for biomarkers gives clinicians information that can be used to diagnose disease and choose therapies that will be of the greatest benefit to patients while sparing them the negative side effects of those that would be of no help. Treating patients in this way is known as personalized medicine and reliable biomarkers are central to its application.

The gene signatures found using Wu and Stein's approach is thought to be more reliable than those found by traditional methods, as they rely upon ensembles of interacting genes rather than a small number of unrelated genes. Another advantage to Wu and Stein's method is that it can probably by applied to a variety of different cancer types.

"We have released the signature-finding algorithm as an open source package to allow the research community to experiment and extend the method," says Stein. His group is already working on an adaptation of the method to allow biomarkers to be identified using genome sequencing data. This has the potential to reduce the cost and complexity of diagnostic tests based on biomarker signatures.

Ontario Institute for Cancer Research

OICR is an innovative cancer research and development institute dedicated to prevention, early detection, diagnosis and treatment of cancer. The Institute is an independent, not-for-profit corporation, supported by the Government of Ontario. The annual budget for OICR, its research partners and collaborators exceeds $150 million. This supports more than 1,600 investigators, clinician scientists, research staff and trainees located at its headquarters and in research institutes and academia across the Province of Ontario. It has research hubs in Hamilton, Kingston, London, Ottawa, Thunder Bay and Toronto. OICR has key research efforts underway in small molecules, biologics, stem cells, imaging, genomics, informatics and bio-computing, from early stage research to Phase III clinical trials. For more information, please visit the website at http://www.oicr.on.ca.

SOURCE: Ontario Institute for Cancer Research

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Researchers use novel method to identify prognostic gene signatures for survival in breast and ovarian cancers

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DIJON, France & LEUVEN, Belgium & PARIS--(BUSINESS WIRE)--

Regulatory News:

Oncodesign, a Drug Discovery company and oncology pharmacology service provider, and the Laboratory for Neurobiology and Gene Therapy (LNGT) at the Department of Neurosciences at the KU Leuven, an expert academic group exploring the roles of LRRK2 and -synuclein in Parkinsons disease headed by Professor Veerle Baekelandt, today announced that they have entered into a research collaboration to evaluate, with Ipsen (Euronext: IPN, ADR: IPSEY) (IPN.PA), Oncodesigns compounds in multiple pharmacology models for Parkinson's disease. The collaboration builds on Oncodesign's LRRK2 program with advanced Nanocyclix lead molecules that was partnered with Ipsen in January 2012.

Our partnership with Ipsen on the discovery of novel therapeutic agents in Parkinsons disease has advanced to a stage where we can use further in depth expertise and advanced pharmacology models to position our leads. We are very excited to collaborate with KU Leuven to advance our understanding of both our inhibitors and the LRRK2 target, said Jan Hoflack, Ph.D., Chief Scientific Officer and Head of Oncodesign's Discovery Activities.

This collaboration with Oncodesign is a perfect example of translational research in action, said Veerle Baekelandt, Ph.D., Principle Investigator of LNGT. Parkinsons disease has been the focus of our research for more than 10 years now. We are very pleased that Oncodesign has selected our lab as a partner for advancing their kinase program, she added.

We are thrilled that the expertise that our lab has built up from fundamental research on LRRK2 can be put to good use in evaluating and developing the biology aspects of compounds with therapeutic potential, said Jean-Marc Taymans, Ph.D., Group Leader of LNGT.

Ipsen and Oncodesign entered into a research collaboration last January for the development of new therapeutic agents against LRKK2 involved in Parkinson's disease, in line with our focus in neurology and movement disorders. We are delighted that our partnership with Oncodesign is moving forward as planned with the objective of developing therapeutics for Parkinsons disease patients. The Oncodesign collaboration with LNGT will greatly accelerate the progress of this research program stated Dr. Claude Bertrand, Executive Vice president, R&D, Chief Scientific Officer at Ipsen.

Under the terms of the agreement, Oncodesign and LNGT will closely collaborate to advance Oncodesign's Parkinsons disease program towards clinical development. LNGT will receive full financial support from Oncodesign for these activities.

About Oncodesign

Founded in 1995 and headed by Dr. Philippe Genne, Oncodesign is a pioneer in the preclinical assessment of anti-cancer therapies, a market that it is leading for many years. Oncodesigns mission consists of discovering effective anti-cancer therapies. Its scientific expertise in pharmacology, imaging and medicinal chemistry, in addition to strong project management skills, support the companys two strategic activities of experimentation and discovery, conducted in partnership with pharmaceutical and biotechnology companies.

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Oncodesign And the Laboratory for Neurobiology and Gene Therapy at The KU Leuven Enter into a Research Collaboration ...

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Dan Becker, The Pillars of Personhood, Part 1, Reformed Theological Seminary, Unedited
Dan Becker, The Pillars of Personhood, Part 1, at Reformed Theological Seminary, RTS, Unedited, Personhood, Personhood USA, Personhood FL, ProLife, Abortion, Euthanasia, Cloning, Fetal Tissue Research, Human Animal Hybrids, Assisted Suicide, PGD, Pre-implantation Genetic Diagnosis, Eugenics, Disabled, Genocide, H+, Homo Perfectus, Transhumanism, Ectogenesis, Transgenetics, Nanotechnology, Cyborgology, Artificial Intelligence, Genoism, Genetic Engineering, EmbryosFrom:Personhood FloridaViews:0 0ratingsTime:50:02More inNews Politics

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Dan Becker, The Pillars of Personhood, Part 2, Reformed Theological Seminary, Unedited
Dan Becker, The Pillars of Personhood, Part 2, at Reformed Theological Seminary, RTS, Unedited, Personhood, Personhood USA, Personhood FL, ProLife, Abortion, Euthanasia, Cloning, Fetal Tissue Research, Human Animal Hybrids, Assisted Suicide, PGD, Pre-implantation Genetic Diagnosis, Eugenics, Disabled, Genocide, H+, Homo Perfectus, Transhumanism, Ectogenesis, Transgenetics, Nanotechnology, Cyborgology, Artificial Intelligence, Genoism, Genetic Engineering, EmbryosFrom:Personhood FloridaViews:0 0ratingsTime:36:45More inNews Politics

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Dan Becker, The Pillars of Personhood, Part 3, Reformed Theological Seminary, Unedited
Dan Becker, The Pillars of Personhood, Part 3, at Reformed Theological Seminary, RTS, Unedited, Personhood, Personhood USA, Personhood FL, ProLife, Abortion, Euthanasia, Cloning, Fetal Tissue Research, Human Animal Hybrids, Assisted Suicide, PGD, Pre-implantation Genetic Diagnosis, Eugenics, Disabled, Genocide, H+, Homo Perfectus, Transhumanism, Ectogenesis, Transgenetics, Nanotechnology, Cyborgology, Artificial Intelligence, Genoism, Genetic Engineering, EmbryosFrom:Personhood FloridaViews:0 0ratingsTime:49:43More inNews Politics

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The Witcher 2012 Teaser
Teaser of my The Witcher Movie - adapted the theme of Sapkowskis books to a modern era by mixing fantasy elements with genetic engineering and modern technologies. One song is by Monster Magnet. Thanks!From:ShawnMcCormickViews:5 0ratingsTime:04:40More inFilm Animation

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The Witcher 2012 Teaser - Video

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Discovery of New Gene Provides Opportunity for Development of New Drugs and Prenatal Screening for Dystonia

New York, NY (PRWEB) December 18, 2012

The findings, published online December 9 in Nature Genetics, provide novel insights into the genetic basis underlying PTD. The research study was led by Laurie Ozelius, PhD, Associate Professor in the Department of Genetics and Genomic Sciences at the Icahn School of Medicine at Mount Sinai. The discovery identifies the human G olf (GNAL) gene, the first PTD gene that directly points to the dopamine signal transduction system as the origin of pathophysiology. Exome sequencing of patients in two families with dystonia revealed mutations in GNAL. Further screening of 39 other families with a history of PTD identified another six mutations in this gene. The research provides the potential opportunity for developing new treatments, and prenatal screening tests.

Dystonia is a movement disorder characterized by repetitive twisting muscle contractions and postures that can affect the face, neck, arms, legs, or torso. Common symptoms include tremors, voice problems, or a dragging foot. The molecular pathophysiology of the disease is poorly understood, in part due to limited knowledge of the genetic basis of the disorder. The disease is most often inherited in an autosomal-dominant manner, with reduced penetrance ranging between 15-60 percent for different forms of PTD. With more than nine loci mapped for PTD, only three genes have been previously identified.

The successful application of exome sequencing for the identification of the GNAL gene proves that this is a powerful and efficient tool which will rapidly accelerate the pace of dystonia gene discovery and consequently, our understanding of the pathways involved in PTD, said Laurie Ozelius, PhD, Associate Professor in the Department of Genetics and Genomic Sciences at the Icahn School of Medicine at Mount Sinai. Any new gene offers the potential to develop new therapeutics, but because GNAL belongs to a well-studied signal transduction pathway, other components in this pathway may also be targets for drug development, said Tania Fuchs, PhD, Instructor in the Department of Genetics and Genomic Sciences at the Icahn School of Medicine at Mount Sinai, who is first author of the paper.

This research was funded in part by the Dystonia Medical Research Foundation, the Bachmann-Strauss Dystonia & Parkinson Foundation, and the National Institute of Health (NIH).

Art Kessler, President of the Dystonia Medical Research Foundation, said, We are delighted that we were able to support this research into the underlying genetic basis of dystonia. While not widely known, dystonia affects more people than muscular dystrophy, Huntington's disease and Lou Gehrig's disease combined. Ive lived with primary torsion dystonia since childhood, so this discovery hits very close to home for my family and for so many others in the community.

Bonnie Strauss, President and Founder of the Bachmann-Strauss Dystonia & Parkinson Foundation commented, There is no definitive test or diagnosis for dystonia, nor is there a known cure. While hundreds of thousands of adults and children suffer from symptoms related to the disease, a large majority of patients never receive a proper prognosis. This exciting new research may provide an opportunity for a definitive genetic test to aid diagnosis and treatment.

Study authors include scientists from Beth Israel Medical Center; Albert Einstein College of Medicine; Scripps Research Institute; University of California, San Francisco; Emory University School of Medicine; Toronto Western Hospital; Jefferson Hospital for Neuroscience; Massachusetts General Hospital, and Institute National de la Sant et la Recherche Mdicale (INSERM).

About The Mount Sinai Medical Center

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Mount Sinai Scientists Discover New Genetic Basis for Dystonia, a Debilitating Movement Disorder Impacting 500,000 ...

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Gun Bros for Windows Phone Gameplay Screencast #27
Thank You For Watching and Please Subscribe !!!! http://www.windowsphone.com Don #39;t be a TOOL.. Enlist with the GUN BROS today! The Freakishly Rugged Advanced Genetics Galactic Enforcement Division (AKA FRAGGED) specializes in the development and deployment of superhuman special agents. Headed since its formation by the brilliant soldier-turned-scientist Mother Gun, its current roster consists of only two active field operatives, code-named Percy and Francis Gun. Their lifelong mission: to protect the cosmos from the Tyrannical Oppressors of Life known as TOOL Like a super-powered fungus gone haywire, the evil TOOL organization has grown from the dankest levels of the criminal underworld to spread its own brand of malevolent funk to every corner of the galaxy. Most recently, they #39;ve set their sights on harvesting the rare element Xplodium in an effort to create even more powerful weapons to enslave the universe... But not if the GUN BROS have anything to do about it! XBOX LIVE ENABLED! Form your own Brotherhood: Add your Xbox LIVE friends to form your brotherhood- your brothers will help protect you and destroy the TOOL enemies. Every time a friend uses your Brother, you gain valuable experience to help your progress, even if you #39;re not currently in the game! HIGH END 3D GRAPHICS Non-stop 3D Action shooter: The waves of TOOL enemies just keep on coming and you and your brother need to have some serious out-of-this-world shooting skills to take those repugnant space bullies down ...From:WP7ScreencastViews:4 0ratingsTime:01:49More inEntertainment

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The Hidden Source Episode 34 -GHOSTBUSTER HACKS-
Myself ThatOneRebel playing some The Hidden Source! Nobody can see The Hidden only trained eyes can see him well! WATCH AS I MURDER EVERYONE AS THE HIDDEN MAHAAAHAHAHA The objective of The Hidden Source is that the humans aka IRIS must eliminate The Hidden to win vice versa for the Hidden but as the title says he is invisible and only is equipped with a knife capable of a one hit kill depending on server and only three grenades. The hidden has many abilities like taunting, super strength to ram objects into IRIS soldiers or be able to leap super high and hang on buildings. Lastly The Hidden can heal himself by eating bodies but only if they are stabbed to death not PIGSTICKED! (which is the one hit kill move) The IRIS are equipped with four weapons ranging from shotgun to rifle to SMG and a few options of equipment like senors to laser optics on your gun. Game is The Hidden Source which requires Half life 2 engine meaning you have to have Half Life 2 purchased already or another source game to run with STORYLINE In the early 1950s human genetics experimentation was taking its first, tentative steps. Amongst many other black projects, a team of British scientists working at an Infinitum Research experimental station stumbled across some remarkable phenomena involving DNA manipulation. This led to deeper research with dangerously unpredictable results, often leading to human patients losing their lives in irresponsible and immoral experiments. Time passed on, and by the mid ...From:ThatOneRebel55Views:9 1ratingsTime:09:49More inGaming

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1 Reason For Slow Female Fat Loss...
Dr. Tara Dall, breaks down 1 major reason for slow female fat loss.. What is insulin resistance? Insulin resistance is a decreased ability of some of the cells of the body to respond to insulin. It is the beginning of the body not dealing well with sugar (and remember that all carbohydrate breaks down into sugar in our bodies). One of insulin #39;s main jobs is to get certain body cells to "open up" to take in glucose (or, more accurately to store the glucose as fat). Insulin resistance happens when the cells essentially don #39;t open the door when insulin comes knocking. When this happens, the body puts out more insulin to stabilize blood glucose (and so the cells can use the glucose). Over time, this results in a condition called "hyperinsulinemia" or "too much insulin in the blood." Hyperinsulinemia causes other problems, including making it more difficult for the body to use stored fat for energy. What causes insulin resistance? We don #39;t know the whole story, but certainly genetics plays a big part. Some people are actually born insulin resistant. Lack of physical activity causes the cells to be less responsive to insulin. Most experts agree that obesity leads to more insulin resistance. However, it almost certainly also works the other way around: Insulin resistance promotes weight gain. So a vicious cycle can be set up with insulin resistance promoting weight gain, which promotes more insulin resistance. What problems does insulin resistance cause? Besides general weight ...From:Michael AndreulaViews:4 0ratingsTime:03:44More inEducation

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Genetics ultimately determines what kind of person are
Genetics ultimately determines what kind of person are changes in communication skills Adaption is evolution truth as soon as it is known "associated memory" physiological vlog voice s daily logical personal thinking individual Psychology examination thinker reasoning ability subjective perspective living interest analyze routine Rationalism show skepticism and criticism voicecast singing songs speak talking discussion of debade evaluation talkin about random stuff speaking music Singer relax philosophy physics cantanteFrom:duffbunchaViews:0 0ratingsTime:05:24:29More inPeople Blogs

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LB Genetics - DNA Testing
DNA Paternity and Family Relationship Testing. Trusted by the Kardashians and the Courts!From:DrJohnTaddieViews:0 0ratingsTime:01:16More inScience Technology

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Human Genetics: Parody of Beauty and a Beat
A Biology Project we had to do 🙂 For: Mr.Moore who likes to run over bunnys.From:Neonnerd12Views:0 0ratingsTime:04:41More inFilm Animation

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CSASmartGroup - Genetics Made Easy for MRCGP CSA Exam.
Visit csasmartgroup.com to get all the materials you need to pass your CSA easily! Get your FREE CSA Video Training Series and CSA E- Book.From:CSASmartGroupViews:0 0ratingsTime:00:09More inEducation

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Turing #39;s Cathedral: Author George Dyson in Conversation with John Hollar
Legendary historian George Dyson vividly re-creates the scenes of focused experimentation, incredible mathematical insight, and pure creative genius that gave us computers, digital television, modern genetics, models of stellar evolution mdash;in other words, computer code. In the 1940s and #39;50s, a group of eccentric geniuses mdash;led by John von Neumann mdash;gathered at the newly created Institute for Advanced Study in Princeton, New Jersey. Their joint project was the realization of the theoretical universal machine, an idea that had been put forth by mathematician Alan Turing. This group of brilliant engineers worked in isolation, almost entirely independent from industry and the traditional academic community. But because they relied exclusively on government funding, the government wanted its share of the results: the computer that they built also led directly to the hydrogen bomb. George Dyson has uncovered a wealth of new material about this project, and in bringing the story of these men and women and their ideas to life, he shows how the crucial advancements that dominated twentieth-century technology emerged from one computer in one laboratory, where the digital universe as we know it was born. Join John Hollar for a captivating conversation with Dyson about John von Neumann and the beginnings of the digital universe.From:ComputerHistoryViews:0 0ratingsTime:53:10More inScience Technology

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Turing's Cathedral: Author George Dyson in Conversation with John Hollar - Video

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When cosmetic surgeon Allan Wu first heard the woman's complaint, he wondered if she was imagining things or making it up. A resident of Los Angeles in her late sixties, she explained that she could not open her right eye without considerable pain and that every time she forced it open, she heard a strange clicka sharp sound, like a tiny castanet snapping shut. After examining her in person at The Morrow Institute in Rancho Mirage, Calif., Wu could see that something was wrong: Her eyelid drooped stubbornly, and the area around her eye was somewhat swollen. Six and a half hours of surgery later, he and his colleagues had dug out small chunks of bone from the woman's eyelid and tissue surrounding her eye, which was scratched but largely intact. The clicks she heard were the bone fragments grinding against one another.

About three months earlier the woman had opted for a relatively new kind of cosmetic procedure at a different clinic in Beverly Hillsa face-lift that made use of her own adult stem cells. First, cosmetic surgeons had removed some the woman's abdominal fat with liposuction and isolated the adult stem cells withina family of cells that can make many copies of themselves in an immature state and can develop into several different kinds of mature tissue. In this case the doctors extracted mesenchymal stem cellswhich can turn into bone, cartilage or fat, among other tissuesand injected those cells back into her face, especially around her eyes. The procedure cost her more than $20,000, Wu recollects. Such face-lifts supposedly rejuvenate the skin because stem cells turn into brand-new tissue and release chemicals that help heal aging cells and stimulate nearby cells to proliferate.

During the face-lift her clinicians had also injected some dermal filler, which plastic surgeons have safely used for more than 20 years to reduce the appearance of wrinkles. The principal component of such fillers is calcium hydroxylapatite, a mineral with which cell biologists encourage mesenchymal stem cells to turn into bonea fact that escaped the woman's clinicians. Wu thinks this unanticipated interaction explains her predicament. He successfully removed the pieces of bone from her eyelid in 2009 and says she is doing well today, but some living stem cells may linger in her face. These cells could turn into bone or other out-of-place tissues once again.

Dozens, perhaps hundreds, of clinics across the country offer a variety of similar, untested stem cell treatments for both cosmetic and medical purposes. Costing between $3,000 and $30,000, the treatments promise to alleviate everything from wrinkles to joint pain to autism. The U.S. Food and Drug Administration (FDA) has not approved any of these treatments and, with a limited budget, is struggling to keep track of all the unapproved therapies on the market. At the same time, pills, oils, creams and moisturizers that allegedly contain the right combination of ingredients to mobilize the body's resident stem cells, or contain chemicals extracted from the stem cells in plants and animals, are popping up in pharmacies and online. There's Stem Cell 100, for example, MEGA STEM and Apple Stem Cell Cloud Cream. Few of these cosmetics have been properly tested in published experiments, yet the companies that manufacture them say they may heal damaged organs, slow or reverse natural aging, restore youthful energy and revitalize the skin. Whether such cosmetics may also produce unintended and potentially harmful effects remains largely unexamined. The increasing number of untested and unauthorized stem cell treatments threaten both people who buy them and researchers hoping to conduct clinical trials for promising stem cell medicine.

When is a skin cream a drug? So far, the FDA has only approved one stem cell treatment: a transplant of bone marrow stem cells for people with the blood cancer leukemia. Among the increasing number of unapproved stem cell treatments, some clearly violate the FDA's regulations whereas others may technically be legal without its approval. In July 2012, for example, the U.S. District Court upheld an injunction brought by the FDA against Colorado-based Regenerative Sciences to regulate just one of the company's several stem cell treatments for various joint injuries as an "unapproved biological drug product." The decision hinged on what constitutes "minimal manipulation" of cells in the lab before they are injected into patients. In the treatment that the FDA won the right to regulate, stem cells are grown and modified in the lab for several weeks before they are returned to patients; in Regenerative Sciences's other treatments, patients' stem cells are extracted and injected within a day or two. Regenerative Sciences now offers the legally problematic treatment at a Cayman Island facility.

Many stem cell cosmetics reside in a legal gray area. Unlike drugs and "biologics" made from living cells and tissues, cosmetics do not require premarket approval from the FDA. But stem cell cosmetics often satisfy the FDA's definitions for both cosmetics and drugs. In September 2012 the FDA posted a letter on its Web site warning Lancme, a division of L'Oral, that the way it describes its Genifique skin care products qualify the creams and serums as unapproved drugs: they are supposed to "boost the activity of genes," for example, and "improve the condition of stem cells." Other times the difference between needing or not needing FDA approval comes down to linguistic nuancethe difference between claiming that a product does something or appears to do something.

Personal Cell Sciences, in Eatontown, N.J., sells some of the more sophisticated stem cellbased cosmetics: an eye cream, moisturizer and serum infused with chemicals derived from a consumer's own stem cells. According to its website and marketing materials, these products help "make skin more supple and radiant," "reduce the appearance of fine lines and wrinkles around the eyes and lips," "improve cellular renewal" and "stimulate cell turnover for renewed texture and tone." In exchange for $3,000, Personal Cell Sciences will arrange for a participating physician to vacuum about 60 cubic centimeters (one quarter cup) of a customer's fat from beneath his or her skin and ship it on ice to American CryoStem Corp. in Red Bank, N.J., where laboratory technicians isolate and grow the customer's mesenchymal stem cells to around 30 million strong. Half these cells are frozen for storage; from the other half, technicians harvest hundreds of different kinds of exuded growth factors and cytokinesmolecules that help heal damaged cells and encourage cells to divide, among other functions. These molecules are mixed with many other ingredientsincluding green tea extract, caffeine and vitaminsto create the company's various "U Autologous" skin care products, which are then sold back to the consumer for between $400 and $800. When the customer wants a refill, technicians thaw some of the frozen cells, collect more cytokines and produce new bottles of cream.

In an unpublished safety trial sponsored by Personal Cell Sciences, Frederic Stern of the Stern Center for Aesthetic Surgery in Bellevue, Wash., and his colleagues monitored 19 patients for eight weeks as they used the U Autologous products on the left sides of their faces. A computer program meant to objectively analyze photos of the volunteers' faces measured an average of 25.6 percent reduction in the volume of wrinkles on the treated side of the face. Analysis of tissue biopsies revealed increased levels of the protein elastin, which helps keep skin taut, and no signs of unusual or cancerous cell growth.

Only skin deep? Supposedly, the primary active ingredients in the U Autologous skin care products are the hundreds of different kinds of cytokines they contain. Cytokines are a large and diverse family of proteins that cells release to communicate with and influence one another. Cytokines can stimulate cell division or halt it; they can suppress the immune system or provoke it; they can also change a cell's shape, modulate its metabolism and force it to migrate from one location to another like a cowboy corralling cattle. Researchers have only named and characterized some of the many cytokines that stem cells secrete. Some of these molecules certainly help repair damaged cells and promote cell survival. Others seem to be involved in the development of tumors. In fact, some recent evidence suggests that the cytokines released by mesenchymal stem cells can trigger tumors by accelerating the growth of dormant cancer cells. Personal Cell Sciences does not pick and choose among the cytokines exuded by its customers' stem cellsinstead, it dumps them all into its skin care products.

Based on the available evidence so far, topical creams containing cytokines from stem cells pose far less risk of cancer than living stem cells injected beneath the skin. But scientists do not yet know enough about stem cell cytokines to reliably predict everything they will do when rubbed into the skin; they could interact with healthy skin cells in a completely unexpected way, just as the unintended interplay between calcium hydroxylapatite and stem cells produced bones in the Los Angeles woman's eye. Stern acknowledges that unusual tissue growth is a concern for any treatment based on stem cells and the chemicals they release. "Down the line, we want to continue watching that," he says. Unlike many other clinics, he and his colleagues have been keeping tabs on their patients through regular follow-ups. John Arnone, CEO of American CryoStem and founder of Personal Cell Sciences, says the fact that U Autologous skin care products contain such a diversity of cytokines does not bother him: "I've seen worse things out there. I've been putting this formulation for almost a year on myself prior to the study. I'm the best guinea pig here."

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In the Flesh: The Embedded Dangers of Untested Stem Cell Cosmetics

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Stem cell therapy True or fiction Dr. Ahmed korie alexandria university
Stem cell therapy True or fiction Dr. Ahmed korie alexandria universityFrom:mansvuViews:2 0ratingsTime:29:49More inEducation

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Stem Cell #39;s explained part 1 on The Susana Kennedy Show on 2oceansvibe
My ever increasing curiosity with the possibilities of Stem Cell therapy recently led me to meeting up with Dr. Duncan Carmichael from The Anti-Aging Clinic in Cape town, we chatted about what stem cell #39;s are, what some of the possibilities are and more, this is part one of a series of interviews I will be releasing over the next few weeks, demystifying the myths and revealing the incredible possibilities that are actually already available to you all right now. Enjoy!From:Susana KennedyViews:2 0ratingsTime:08:32More inScience Technology

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NEW YORK & PETACH TIKVAH, Israel--(BUSINESS WIRE)--

BrainStorm Cell Therapeutics (BCLI), a leading developer of adult stem cell technologies for neurodegenerative diseases, announced today that it has signed an agreement with Octane Biotech of Kingston, Ontario, to jointly develop a proprietary bioreactor for production of its NurOwn stem cell therapy candidate. The customized bioreactor will enable BrainStorm to optimize its NurOwn production process, significantly increasing its production capabilities by using a single clean room for multiple patients, reducing costs and time. The project is supported by a grant awarded by the Canada-Israel Industrial Research and Development Foundation (CIIRDF).

Under the terms of the agreement, the companies will develop a commercially viable, safe, reliable, and cost-effective bioreactor for scale-up of BrainStorms NurOwn stem cell therapy, using Octanes Automated Cell & Tissue Engineering System (ACTES) technology. The CIIRDF funding award was approved for a period of three years.

Octane is the ideal partner for us, since they have a particular expertise in developing automated production processes for mesenchymal cell therapy technologies, commented Dr. Adrian Harel, BrainStorms CEO. We are anxious to move ahead with this project, in order to be in a position to provide NurOwn as quickly as possible, and to as many patients as possible, in the near future.

The opportunity to work with BrainStorm on scaling-up the NurOwn production process is a particularly meaningful one, given the urgency of its target population, said Dr. Tim Smith, Octanes CEO. We are confident that our combined knowledge base and commitment to the project will help advance their product significantly closer to clinical use.

BrainStorm is currently conducting a Phase I/II clinical trial in ALS patients at the Hadassah Medical Center in Jerusalem and is planning to expand its clinical development in the USA, pending FDA approval. Towards that goal, the Company has entered into a Memorandum of Understanding with the University of Massachusetts Medical School and Massachusetts General Hospital to begin ALS human clinical trials at these institutions.

About BrainStorm Cell Therapeutics

BrainStorm Cell Therapeutics Inc. is a biotechnology company engaged in the development of first-of-its-kind adult stem cell therapies derived from autologous bone marrow cells for the treatment of neurodegenerative diseases. The Company holds the rights to develop and commercialize its NurOwn technology through an exclusive, worldwide licensing agreement with Ramot, the technology transfer company of Tel Aviv University. For more information, visit the companys website at http://www.brainstorm-cell.com.

About Octane Biotech

Octane develops innovative bioreactor-based systems to meet the production challenges inherent in the progressive scale-up of manual cell culture protocols. The companys unique Automated Cell & Tissue Engineering System (ACTES) solution integrates state-of-the-art bioreactors, biosensors and bioprocessing to enable routine GMP production of cell-based products for clinical therapeutics. Octane Biotech Inc. is one of three affiliated companies within the Octane Medical Group. For more information, visit the companys website at http://www.octaneco.com.

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BrainStorm and Octane to Develop Revolutionary Bioreactor-Based NurOwn Stem Cells Production Process

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WASHINGTON & SARATOGA, Calif.--(BUSINESS WIRE)--

The Myelin Repair Foundation (MRF) today announced the support of the Ballenger Trust to accelerate the development of myelin repair therapeutics for multiple sclerosis (MS). The $700,000 gift will provide support for the MRF biomarker project, myelin repair research in human brain tissue and a repurposing opportunity. With the Ballenger Trusts support, these critical projects will accelerate the Myelin Repair Foundations research to develop a myelin repair therapeutic for multiple sclerosis.

The trustee of the Ballenger Trust, Chris Ballenger, selected the Myelin Repair Foundation to honor his fathers wish to accelerate new treatments for multiple sclerosis. Chris Ballengers sister Jacqueline passed away in 2009 from complications of MS. The MRF biomarker, human cell myelin repair assay and drug repositioning projects were selected for support by the Ballenger Trust to ensure promising myelin repair therapeutics enter clinical trials and benefit patients with MS.

The Myelin Repair Foundations myelin research for MS brings hope to patients with the disease, said Chris Ballenger, trustee of the Ballenger Trust. It was important for my father, John Ballenger to leave a long-lasting legacy to advance new treatments for those suffering from multiple sclerosis. With the Myelin Repair Foundations pioneering work in advancing myelin research into a drug for patients, I believe its our best chance to making my fathers dreams a reality.

We applaud the forward-thinking perspective of the Ballenger Trust to support several of our programs to advance promising myelin research, said Scott Johnson, CEO, President and Founder of the Myelin Repair Foundation. With their critical support, we are committed to honoring the memories of both John and Jacqueline Ballenger by continuing our progress towards developing a myelin repair drug for MS by 2019.

About the Myelin Repair Foundation

The Myelin Repair Foundation (MRF) (http://www.myelinrepair.org) is a Silicon Valley-based, non-profit research organization focused on accelerating the discovery and development of myelin repair therapeutics for multiple sclerosis. Its Accelerated Research Collaboration (ARC) model is designed to optimize the entire process of medical research, drug development and the delivery of patient treatments.

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Ballenger Trust Selects the Myelin Repair Foundation to Advance Myelin Repair Therapeutic Development for Multiple ...

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Future Direction of Molecular and Personalized Medicine in Breast Cancer
Breast cancer research has reached the precipice of a new era in molecular and personalized medicine. Genome sequencing studies are finding cohesive data on driver mutation and possible targets for treatment. Going forward, the challenge facing researchers is translating these findings into clinically meaningful benefits for patients. For more from this discussion, visit http://www.onclive.comFrom:OncLiveTVViews:6 0ratingsTime:06:16More inEducation

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Future Direction of Molecular and Personalized Medicine in Breast Cancer - Video

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Eduardo Vilar-Sanchez, MD, PhD: Genomics of Cancer and Personalized Medicine
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Eduardo Vilar-Sanchez, MD, PhD: Genomics of Cancer and Personalized Medicine - Video

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