Public release date: 7-Nov-2012 [ | E-mail | Share ]

Contact: Vicki Cohn vcohn@liebertpub.com 914-740-2100 Mary Ann Liebert, Inc./Genetic Engineering News

New Rochelle, NY, November 7, 2012Premenopausal use of hormonal contraceptives may improve the cognitive abilities of women in midlife and for years afterward. This finding may have implications for prevention of declining cognitive function that occurs with advancing age and in diseases such as Alzheimer's. The beneficial effects of hormones increase the longer a woman uses them, as described in a study published in Journal of Women's Health, a peer-reviewed publication from Mary Ann Liebert, Inc., publishers. The article is available free on the Journal of Women's Health website at http://www.liebertpub.com/jwh.

Kelly Egan, University of Wisconsin School of Medicine and Public Health, and Carey Gleason, PhD, William S. Middleton Memorial Veterans Hospital, Madison, WI, present the results of cognitive performance tests administered to women enrolled in the Wisconsin Registry for Alzheimer's Prevention in the article "Longer Duration of Hormonal Contraceptive Use Predicts Better Cognitive Outcomes Later in Life."

"This study provides preliminary evidence that hormonal contraceptives may have a protective cognitive effect, even years after use is discontinued," says Editor-in-Chief Susan G. Kornstein, MD, Editor-in-Chief of Journal of Women's Health, Executive Director of the Virginia Commonwealth University Institute for Women's Health, Richmond, VA, and President of the Academy of Women's Health.

###

About the Journal

Journal of Women's Health, published monthly, is a core multidisciplinary journal dedicated to the diseases and conditions that hold greater risk for or are more prevalent among women, as well as diseases that present differently in women. The Journal covers the latest advances and clinical applications of new diagnostic procedures and therapeutic protocols for the prevention and management of women's healthcare issues. Tables of content and a sample issue may be viewed on the Journal of Women's Health website at http://www.liebertpub.com/jwh. Journal of Women's Health is the Official Journal of the Academy of Women's Health and the Society for Women's Health Research.

About the Academy

Academy of Women's Health (http://www.academyofwomenshealth.org) is an interdisciplinary, international association of physicians, nurses, and other health professionals who work across the broad field of women's health, providing its members with up-to-date advances and options in clinical care that will enable the best outcomes for their women patients. The Academy's focus includes the dissemination of translational research and evidence-based practices for disease prevention, diagnosis, and treatment of women across the lifespan.

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Longer use of hormonal contraception during midlife predicts better cognitive function later

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Public release date: 7-Nov-2012 [ | E-mail | Share ]

Contact: Donna Dubuc donna.m.dubuc@hitchcock.org 603-653-3615 Dartmouth-Hitchcock Medical Center

(Lebanon, NH, 11/5/2012) Dartmouth researchers have found that duration of ibuprofen use was associated with a reduced risk of bladder cancer in patients in northern New England, which has a high mortality rate of this disease. In a 2012 collaborative project with the National Cancer Institute, Margaret Karagas, PhD, co-director, Cancer Epidemiology & Chemoprevention program at Norris Cotton Cancer Center, and Professor of Community and Family Medicine at the Geisel School of Medicine at Dartmouth, and Richard Waddell, D.Sc, Research Assistant Professor of Medicine at the Geisel School of Medicine, looked for connections between ibuprofen use and bladder cancer.

Bladder cancer and ibuprofen use

Karagas did an earlier study on the relationship between bladder cancer and nonsteroidal anti-inflammatory drugs (NSAIDs) usage in New Hampshire. The new study included patients in Vermont and Maine. Researchers enrolled 1,171 participants newly diagnosed with bladder cancer and 1,418 participants who did not have bladder cancer. Karagas also added a genetic component looking at thirty-nine genes related to NSAID metabolism and studied a new class of NSAIDs known as selective cyclooxygenase (COX-2) inhibitors, such as celecoxib (Celebrex). Their results were published in the International Journal of Cancer (June 2012).

Those with specific genetic traits appear to have reduced risk

The findings in the recent study suggest that "regular use of nonaspirin nonselective NSAIDs, particularly ibuprofen, may reduce bladder cancer risk, especially among regular users for 10 years or more." However, the study also notes that observed reduction in risk was specific to individuals carrying a specific allele (or variant of a gene) related to NSAID metabolism.

Findings suggest further study needed for newer prescription pain reliever

For Karagas one of the novel findings was a trend of an increased risk of bladder cancer for those using selective COX-2 inhibitors, especially celocoxib (Celebrex). Karagas warns against leaping to any conclusions, noting, "further investigation is needed."

Karagas also stresses that this study "does not make any recommendations. It does not, in any way, suggest that patients begin taking ibuprofen as a prophylactic measure against bladder cancer, nor should patients go off any medicine prescribed by their doctor."

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Researchers explore connection between popular pain relievers, bladder cancer

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MENLO PARK, Calif., Nov. 6, 2012 (GLOBE NEWSWIRE) -- Pacific Biosciences of California, Inc. (PACB) provider of the PacBio(R)RS High Resolution Genetic Analyzer, today announced the latest enhancements to its DNA sequencing system, the XL release featuring new chemistry and software for extraordinarily long read lengths that average 5,000 bases.

Pacific Biosciences' Single Molecule, Real-Time (SMRT(R)) sequencing generates reads an order of magnitude longer than other leading DNA sequencing technologies. With the latest advance, the average read length increases 67 percent from 3,000 to 5,000 bases, with some reads as long as 20,000 bases. Long reads are critical for resolving genetic complexity in applications such as the assembly and finishing of genomes, phasing genomic variation over long distances, understanding human nucleotide repeat disorders, and resolving the structure of alternatively spliced transcripts.

The new XL release provides increased read lengths through a combination of chemistry and software. The new chemistry includes a faster polymerase that reads more bases per second. This release also includes the Stage Start feature, which produces longer reads by enabling sequence data collection to begin when the polymerase is activated. Additionally, PacBio has increased the length of time the instrument can record data during the sequencing reaction, also contributing to an increase in read lengths.

"The XL release is an enhancement to our existing C2 chemistry to address applications that require the longest reads, like de novo assembly," said Dr. Jonas Korlach, Chief Scientific Officer of Pacific Biosciences. "A unique characteristic of our SMRT sequencing technology is the ability to tune the experimental design to maximize results for the project's application and goals. Through this flexibility and our continued performance enhancements, our customers can carry out their current research projects more efficiently, and engage in new applications to help resolve very complex genomes and transcriptomes."

The utility of the latest upgrade was demonstrated by scientists at Cold Spring Harbor Laboratory who were trying to assemble the complex rice genome. The new chemistry produced 9x coverage with long reads -- 50% of the data came from reads 4,800 base pairs or longer. Commenting on the results, Assistant Professor Dr. Mike Schatz at Cold Spring Harbor said, "Adding the long reads from PacBio doubled the contig connectivity over the current state-of-the-art ALLPATHS-LG assembler and mate-pair recommendations."

Dr. Korlach will discuss the latest enhancements to the PacBio RS in a workshop at the American Society for Human Genetics (ASHG) Annual Meeting in San Francisco on November 8 at 12:45 p.m. Also speaking to share their successes using the PacBio RS are customers Dr. Paul Hagerman from UC Davis School of Medicine ("Sequencing the Unsequenceable: Expanded CGG-repeat Alleles of the Fragile X Gene"), Dr. Hagen Tilgner, Stanford University Department of Genetics ("Eukaryotic Transcriptome Analysis Using PacBio"), and Dr. David Witherspoon, University of Utah Department of Human Genetics Sequencing ("Mobile-Element Scanning (ME-Scan) of Active LINE-1 Elements in Humans using Single Molecule, Real-Time (SMRT) Sequencing").

Attendees at the ASHG Annual Meeting can visit any of the workshop sessions taking place from 12:45-2:15 p.m. and visit the PacBio booth (#610). Those not attending the meeting can register to view recordings of the workshop sessions on the company's website. For more information, please visit http://www.pacb.com.

About Pacific Biosciences

Pacific Biosciences of California, Inc. (PACB) offers the PacBio(R)RS High Resolution Genetic Analyzer to help scientists solve genetically complex problems. Based on its novel Single Molecule, Real-Time (SMRT(R)) technology, the company's products enable: targeted sequencing to more comprehensively characterize genetic variations; de novo genome assembly to more fully identify, annotate and decipher genomic structures; and DNA base modification identification to help characterize epigenetic regulation and DNA damage. By providing access to information that was previously inaccessible, Pacific Biosciences enables scientists to increase their understanding of biological systems.

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Pacific Biosciences Delivers Enhanced DNA Sequencing Chemistry and Software to Help Solve Complex Genetic Problems

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Washington, November 8 (ANI): Regular use of ibuprofen may help reduce risk of bladder cancer, especially in those with certain genetic marker, a new study has found.

In a 2012 collaborative project with the National Cancer Institute, Margaret Karagas, PhD, co-director, Cancer Epidemiology and Chemoprevention program at Norris Cotton Cancer Center, and Professor of Community and Family Medicine at the Geisel School of Medicine at Dartmouth, and Richard Waddell, D.Sc, Research Assistant Professor of Medicine at the Geisel School of Medicine, looked for connections between ibuprofen use and bladder cancer.

Karagas did an earlier study on the relationship between bladder cancer and nonsteroidal anti-inflammatory drugs (NSAIDs) usage in New Hampshire.

The new study included patients in Vermont and Maine. Researchers enrolled 1,171 participants newly diagnosed with bladder cancer and 1,418 participants who did not have bladder cancer. Karagas also added a genetic component looking at thirty-nine genes related to NSAID metabolism and studied a new class of NSAIDs known as selective cyclooxygenase (COX-2) inhibitors, such as celecoxib (Celebrex).

The findings in the recent study suggested that "regular use of nonaspirin nonselective NSAIDs, particularly ibuprofen, may reduce bladder cancer risk, especially among regular users for 10 years or more."

However, the study also noted that observed reduction in risk was specific to individuals carrying a specific allele (or variant of a gene) related to NSAID metabolism.

For Karagas one of the novel findings was a trend of an increased risk of bladder cancer for those using selective COX-2 inhibitors, especially celocoxib (Celebrex).

But Karagas warns against leaping to any conclusions, noting, "further investigation is needed."

Karagas also stresses that this study "does not make any recommendations. It does not, in any way, suggest that patients begin taking ibuprofen as a prophylactic measure against bladder cancer, nor should patients go off any medicine prescribed by their doctor."

Their results were published in the International Journal of Cancer (June 2012). (ANI)

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Regular ibuprofen use cuts bladder cancer risk

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Public release date: 7-Nov-2012 [ | E-mail | Share ]

Contact: Bonnie Davis bdavis@wakehealth.edu 336-716-4977 Wake Forest Baptist Medical Center

WINSTON-SALEM, N.C. Nov. 7, 2012 World-renowned scientists are taking what they've learned from their multicenter research collaboration studying the health impact of fatty acids on diverse populations to set up a genetics center in India.

Wake Forest Baptist Medical Center researchers Floyd H. "Ski" Chilton, Ph.D., and Avinash K. "Avi" Shetty, M.D., are studying genetic differences in populations related to how they convert certain dietary fats known as polyunsaturated fatty acids (PUFAs).

"Given that one third of all severely malnourished children are in India, it is vital to understand the distribution of gene variants that impact long-chain PUFA synthesis in this country," Chilton said. "We're particularly interested in PUFAs because they are so critical for brain and immune development early in life."

With new grant funding from the National Institutes of Health, they will take their research to the coastal city of Mangalore in the state of Karnataka in Southern India to study its diverse populations and their genetic capacity to make PUFAs that are critical for brain, eye and immune system development.

The collaboration brings together Wake Forest Baptist, the Johns Hopkins School of Medicine and the NITTE University/K.S. Hegde Medical Academy/AB Shetty Memorial Institute of Dental Sciences in Mangalore. Chilton, a professor of physiology and pharmacology and director of the Center for Botanical Lipids and Inflammatory Disease Prevention at Wake Forest Baptist, and Shetty, a professor of pediatrics, have a long collaborative history with Rasika S. Mathias, ScD., and Kathleen Barnes, Ph.D., of Johns Hopkins.

The researchers have published numerous papers over the last several years highlighting how variations within a set of genes, known as the FADS gene cluster on chromosome 11, impact PUFA metabolism in African and European ancestry populations as well as other populations around the world. Specifically, they have found that genetic variation within the FADS cluster has undergone intense natural selection and thereby led to different frequencies in the differing populations. Given these observations, the team is performing ongoing research to understand whether the dramatic increase in dietary omega-6 PUFAs found in the modern "western" diet harms certain populations more than others.

Chilton said he envisions a day when malnutrition could be optimally addressed by knowing how different populations utilize dietary components such as PUFAs. "It may be that one malnourished population requires one set of nutrients and another a different set of nutrients," he said.

Long-chain PUFAs such as docosahexaenoic acid (DHA) and arachidonic acid (AA), are vital for brain and eye development. Specifically, normal visual and cognitive development is dependent on an adequate supply of DHA and AA in synapses and photoreceptors. Additionally, said Chilton, a lack of LCPUFAs or an imbalance between omega 3 and omega 6 fatty acids has been associated with a number of behavioral abnormalities, as well as neurological and psychiatric disorders in both children and adults, particularly attention deficit hyperactivity (ADHD) and autism spectrum disorders, as well as unipolar and bipolar disorders.

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Wake Forest Baptist research goes global with genetic center in India

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Coast To Coast AM Feb 20 2012 Space Missions, Genetic Manipulation and Prophecy
Coast to Coast AM is a North American (US and Canada) late-night radio talk show that deals with a variety of topics, but most frequently ones that relate to either the paranormal or conspiracy theories. The program currently airs seven nights a week 1:05 am -- 5:00 am Eastern Time (10:05 pm -- 2:00 am Pacific Time). Originally created and hosted by Art Bell, as of 2012 the program is hosted on most nights by George Noory. According to estimates by Talkers Magazine, Coast to Coast AM draws approximately 3 million listeners, making it the most listened-to program in its time slot Format and subject matter The Coast to Coast AM format consists of a combination of live callers and long format interviews. The subject matter covers unusual topics and is full of personal stories related to callers. While program content is often focused on paranormal and fringe subjects, sometimes world class scientists such as Michio Kaku and Brian Greene are featured in long format interviews. Topics discussed include the Near-death experience, climate change, cosmology, quantum physics, remote viewing, hauntings, contact with extraterrestrials, psychic reading, metaphysics, conspiracy theories, Area 51, crop circles, cryptozoology, Bigfoot, the Hollow Earth hypothesis, and science fiction literature, among others. Since the September 11, 2001 attacks, the events of that day (as well as alternate theories surrounding them) and current US counter-terrorism strategy have also become frequent ...From:C2CVAULTViews:0 0ratingsTime:02:33:14More inEducation

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Coast To Coast AM Feb 20 2012 Space Missions, Genetic Manipulation and Prophecy - Video

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Coast To Coast AM Feb 21 2012 Mind Power and Change
Coast to Coast AM is a North American (US and Canada) late-night radio talk show that deals with a variety of topics, but most frequently ones that relate to either the paranormal or conspiracy theories. The program currently airs seven nights a week 1:05 am -- 5:00 am Eastern Time (10:05 pm -- 2:00 am Pacific Time). Originally created and hosted by Art Bell, as of 2012 the program is hosted on most nights by George Noory. According to estimates by Talkers Magazine, Coast to Coast AM draws approximately 3 million listeners, making it the most listened-to program in its time slot Format and subject matter The Coast to Coast AM format consists of a combination of live callers and long format interviews. The subject matter covers unusual topics and is full of personal stories related to callers. While program content is often focused on paranormal and fringe subjects, sometimes world class scientists such as Michio Kaku and Brian Greene are featured in long format interviews. Topics discussed include the Near-death experience, climate change, cosmology, quantum physics, remote viewing, hauntings, contact with extraterrestrials, psychic reading, metaphysics, conspiracy theories, Area 51, crop circles, cryptozoology, Bigfoot, the Hollow Earth hypothesis, and science fiction literature, among others. Since the September 11, 2001 attacks, the events of that day (as well as alternate theories surrounding them) and current US counter-terrorism strategy have also become frequent ...From:C2CVAULTViews:0 0ratingsTime:02:33:57More inEducation

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Coast To Coast AM Feb 21 2012 Mind Power and Change - Video

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Watch How To Overcome Infertility - How To Get Pregnant - The Pregnancy Miracle System
click here to learn more==)) yupurl.com Tags: Education Pregnant Womb Baby Abortion Birth Born Newborn Pregnancy (Disease Cause) Infant (Risk Factor) Education. in-vitro-fertilization. Pregnancy (mammals). camera phone. Trans-Video Phone Service. For over 50 years, your local, family-owned communications company! Babies (film). World Wide Sires, Ltd. is the world #39;s leading cattle genetics marketing organization representing the majority of the US Artificial Insemination Cooperatives. I think of old May Day traditions, girls dancing around its trunk with blossom falling, ties to fertility, love and happiness. Liz Chiu. More favourite trees. Welcome To Fertility Centers Of New England If you are having difficulty conceiving, you #39;ve come to the right place. This is the right place to discuss about file sharing, P2P networks and P2P software. AED Pregnancy Registry; Additional Resources; Research eNewsletter; The only way to cure epilepsy is through research and new discoveries. Upload a new icon. Icons must be PNG, GIF, or JPEG and less than 1 MiB in size. They will be displayed as 48x48 images.From:fatfatloseViews:0 0ratingsTime:02:07More inEntertainment

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Watch How To Overcome Infertility - How To Get Pregnant - The Pregnancy Miracle System - Video

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http://www.dna-matrix.net BRAiND DNA of Moscow - is love forever
Our genetic history. http://www.dna-matrix.net Human history shows that in life there are no coincidences, - there are certain patterns that develop in certain laws of physics, astronomy, astrology, numerology, sfayrologii, Kabbalah and genetics, which leads scientists to believe that there is some matrix of each event in a person #39;s life. Compatibility matrix at different events around the person and the matrix of the inner world of the individual, which is dictated by the genes of the person - shows strong gene, which can withstand the test of time, and because most people disclose their genetic potential and become successful, self realized, self-sufficient in all areas of life. Therefore, if you know your DNA template, you can find its genetic partner on creativity, on business, to study or to create a strong and happy family. Our project gives you this opportunity! Based on the latest findings of the above research, we possess the copyright, we calculate for you personally to your genetic predisposition to events, goods or services. Help identify and discover your strong gene and create a franchise of your family, such as a genetic business, DNA dynasty which successfully continue your children, grandchildren and great grandchildren. And this is a bright future for your children! Prepare the world for the birth of your children!From: #1057; #1074; #1103; #1090; #1086; #1089; #1083; #1072; #1074; #1042; #1080; #1090; #1072; #1096; #1086; #1074;Views:4 2ratingsTime:06:08More inPeople Blogs

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http://www.dna-matrix.net BRAiND DNA of Moscow - is love forever - Video

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Thames Kosmos Biology Genetics and DNA
Special Price Link: http://www.demizzy.com Isolate the DNA from a tomato Learn about inheritance and how traits are expressed Build a DNA model Breed bacteria to experiment with genetic engineering Best Seller In depth investigation of genetics and DNA. Isolate the DNA from a tomato. learn about inheritance and how traits are expressed. build a DNA model. breed bacteria to experiment with genetic engineering. The full-color. 48-page manual guides your experiments.From:HeidiDAlvarezRViews:0 0ratingsTime:00:50More inPeople Blogs

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Thames

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Genetic Diagnosis Of Endocrine Disorders
ll4.me Genetic Diagnosis Of Endocrine Disorders Since the beginning of the current century, endocrine disease diagnosis and treatment have moved beyond the standard hormone measurements. While, indeed elevated thyroid hormone levels or low insulin levels signal a specific endocrine disease, correct diagnosis (and therefore correct treatment) depends on an understanding of the molecular basis for the disease. This book will present the "bench to bedside" approach of our understanding of the genetic basis for endocrine disease. It will be organized by endocrine grouping (eg Thyroid, Pancreas, Parathyroid, Pituitary, Adrenal, Reproductive and Bone) and genetic/molecular basis for the diagnosis of the various disorders will be discussed. Emphasis will be placed on the practical nature of diagnosing a disease. For example: 1. Which tests should be done for the diagnosis of Diabetes mellitus Type I in children who presented at less than 6 months; at less than 12 years, in adulthood, etc., and why should those tests be done?; 2. Which genes should be evaluated for subjects with congenital hypothyroidism; 3. Which genetic tests should be ordered in obesity?; 4. Which genetic test should be ordered in a patient with Parathyroid Carcinoma?; 5. What is the rationale behind testing for Multiple Endocrine Neoplasia? The field of genetic diagnosis of disease is exploding now, with multiple laboratories developing tests for current clinical use. Most practicing endocrinologists and ...From:ericathompson327Views:0 0ratingsTime:00:14More inPeople Blogs

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Genetic Diagnosis Of Endocrine Disorders - Video

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One Piece 688 Manga Chapter Review- Giant Genetics #12527; #12531; #12500; #12540; #12473;
What do you think of my crazy theory? xD CodeProvider on Facebook: tinyurl.com CodeProvider on Twitter: twitter.com Subscribe to CodeProvider: tiny.ccFrom:CodeProviderViews:573 60ratingsTime:05:30More inEntertainment

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Dr. Jack Yanovski: Defining Hyperphagia
Conference on Hyperphagia (2012) "Defining Hyperphagia" Jack A. Yanovski, MD, Ph.D Chief. Section on Growth and Obesity Program in Developmental Endocrinology and Genetics National Institute of Child Health and Human Development National Institute of Health © Copyright 2012 Pennington Biomedical Research CenterFrom:penningtonbiomedicalViews:1 0ratingsTime:29:56More inEducation

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Genetics and Heredity
Mrs. Inabinet describes genetics and heredity.From:MrsInabinetViews:0 0ratingsTime:15:01More inEducation

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Genetics and Heredity - Video

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Diagnostic Techniques In Genetics
ll4.me Diagnostic Techniques In Genetics EAN/ISBN : 9780470870266 Publisher(s): John Wiley Sons, Wiley Format: ePub/PDF Author(s): Serre, Jean-Louis - Heath, Isabelle - Heath, Simon EAN/ISBN : 9780470870266 Publisher(s): John Wiley Sons, Wiley Format: ePub/PDF Author(s): Serre, Jean-Louis - Heath, Isabelle - Heath, SimonFrom:dustinphillips654Views:0 0ratingsTime:00:12More inPeople Blogs

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Diagnostic Techniques In Genetics - Video

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CELLULITE IN BRIEF - REDUCE CELLULITE USING REJUV, DR. CELLULITE
http://www.drcellulite.ca - Cellulite builds up in the subcutaneous layer beneath the skin as collections of fat - - nothing new. Right? But, remember, a layer of fat beneath the skin doesn #39;t always mean CELLULITE. We all have a layer of fat beneath the skin. Individual amounts depend on weight, life style and genetics. The layer of fat is an insulator for the body that cushions our organs, muscles and nerves. What are the body areas where cellulite builds up? Right! Cellulite builds up in women #39;s (slow down) thighs, buttocks, abdomen, breasts, upper arms and nape. The nape is the back of the neck. In most cases, cellulite builds up in women #39;s thighs and buttocks. Women #39;s thighs and buttocks are more vulnerable to fat cell accumulation. In most cases, cellulite builds up in women #39;s thighs and buttocks, because these areas are more vulnerable to fat cell accumulation. The skin becomes thinner and less supple as women age, the fat cells becoming more visible. Collagen fibers connecting fat to the skin stretch or pull tight, allowing the fat cells to bulge out. Men may also get cellulite, mostly in the neck and abdomen. But, unlike women, not even 5% of men get cellulite. Cellulite is rare in men, because the epidermis, dermis and the subcutaneous layer are different in men. Men have thicker epidermis and dermis tissue layers in their thighs and buttocks. Only men who are deficient in male hormones may have a subcutaneous fat appearance similar to females. Variation in hormones ...From:KOSTAS POLYCHRONISViews:0 0ratingsTime:02:06More inHowto Style

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How to solve Dihybrid Crosses- Genetics
1. Find the Parent Genotypes 2. Find the possible parent gametes 3. write in offspring genotypes 4. Calculate genotype and PhenotypeFrom:Man DViews:1 0ratingsTime:06:30More inFilm Animation

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David Icke: Human Genetics, The Religion of Death
Alex talks with author and presenter David Icke about election fraud and human genetics. http://www.davidicke.com http://www.infowars.com http://www.prisonplanet.tvFrom:BBC6NewsChannelViews:0 0ratingsTime:58:00More inEducation

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Fallen Angels Biblical Prophecy
Fallen Angels Biblical Prophecy UFO researcher and student of ancient manuscripts, LA Marzulli shared his views on the Nephilim (fallen angels), aliens, biblical prophecy and the Apocalypse. He described a "Luciferian end game" that would take place, possibly after a nuclear attack in the Middle East-- UFOs would appear over cities, and there would be full alien disclosure, crediting the ETs with evolving the human species through genetics. Yet, this will be a demonic deception, he warned, setting people up for the Antichrist. The murders committed by the Nazis during the Holocaust were a kind of "Luciferic sacrifice" that may have opened up portals for fallen angels to enter into our realm, said Marzulli, who noted the rise in UFO sightings directly after WWII. Anomalous creatures such as Mothman may also have arrived through a portal, he conjectured. Marzulli offered analysis of the Fatima incident of 1917 in Portugal. The apparitions seen by some 70000 people were not of Mary of the Bible, but rather a type of deception, he believes. A fourth witness was said to have seen an additional figure-- a child with stringy hair, which he related to the genetic experiments/hybrids associated with alien lore. Tax Protest Update First hour guest Elaine Brown shared an update on the situation surrounding the tax protest she and her husband Ed are involved in. She was joined by Gulf War advocate Joyce Riley, who has befriended the Browns for a number of years. The Browns are ...From:DisclosureBubbleViews:0 0ratingsTime:02:34:23More inScience Technology

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Sanford-Burnham speaks with Nobel Laureate Bruce Beutler
Bruce Beutler, MD, professor and director of the Center for the Genetics of Host Defense at UT Southwestern, shared the 2011 Nobel Prize in Physiology or Medicine for his studies of the innate immune system. Working with mice, he discovered toll-like receptors, cellular sensors that recognize bacteria and activate inflammation. Dr. Beutler visited Sanford-Burnham #39;s La Jolla campus to meet with colleagues and deliver a special lecture to a packed auditorium. He also serves on our Scientific Advisory Board. While he was here, we sat down with Dr. Beutler and asked him a few questions about what inspired him to become a scientist, what he #39;s most proud of, where his field is headed in the next decade, and how his life has changed since winning the Nobel Prize.From:SanfordBurnhamViews:3 0ratingsTime:03:35More inScience Technology

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Sanford-Burnham speaks with Nobel Laureate Bruce Beutler - Video

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Alex Jones Show - David Icke: Human Genetics, The Religion of Death
Tuesday November 6th 2012 Alex talks with author and presenter David Icke about election fraud and human genetics. http://www.davidicke.com Alex Jones Show Complete Playlist: http://www.youtube.com Infowars Nightly News Complete Playlist: http://www.youtube.com Infowars Special Reports Playlist: http://www.youtube.com http://www.infowars.com http://www.prisonplanet.tv http://www.prisonplanet.com httpFrom:AlexJonesCompleteViews:32 4ratingsTime:01:00:04More inNews Politics

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Human Genetics, The Religion of Death : David Icke
David Icke Human Genetics, The Religion of Death Follow InfoWars Live twitter.com Alex Jones InfoWars !From:InfoWarsLiveViews:2 1ratingsTime:58:00More inNews Politics

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Seattle Genetics, Inc. (SGEN: Quote) Wednesday reported a narrower loss for the third quarter, helped mainly by higher revenues. The company also provided an outlook for the fiscal year 2012, which are currently below analysts' expectations.

Net loss for the quarter improved to $13.7 million or $0.12 per share from $40.7 million or $0.35 per share in the same period last year.

On average, 11 analysts polled by Thomson Reuters expected the company to report a loss of $0.15 per share for the quarter. Anlaysts' estimates typically exclude special items.

Revenues totaled $33.7 million, up from $10.0 million last year. Analysts expected revenues of $52.66 million.

Looking ahead to the fiscal year 2012, the company has forecast revenues in the range of $132 million to $137 million. Analysts expect revenues of $209.03 million.

Seattle Genetics closed Wednesday's trade at $24.47, down 2.12%. Shares dropped 8.05% to $22.50, losing $1.97 in the extended trade on the Nasdaq.

Click here to receive FREE breaking news email alerts for SEATTLE GENETICS INC and others in your portfolio

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Seattle Genetics Q3 Loss Narrows, Sees FY12 Outlook Below View - Quick Facts

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Public release date: 7-Nov-2012 [ | E-mail | Share ]

Contact: Phyllis Edelman pedelman@genetics-gsa.org 301-634-7302 Genetics Society of America

Bethesda, MDNovember 7, 2012 Listed below are the selected highlights for the November 2012 issue of the Genetics Society of America's journal, GENETICS. The November issue is available online at http://www.genetics.org/content/current. Please credit GENETICS, Vol. 192, November 2012, Copyright 2012.

Please feel free to forward to colleagues who may be interested in these articles.

ISSUE HIGHLIGHTS

An ex vivo model for imprinting: Mutually exclusive binding of Cdx2 and Oct4 as a switch for imprinted and random X-inactivation, pp. 857 Jennifer A. Erwin, Brian del Rosario, Bernhard Payer, and Jeannie T. Lee X chromosome inactivation (XCI) is initially seen only on the parental X chromosome during embryogenesis. This imprinted XCI later becomes random, occurring on either the maternal or paternal X. This article describes a cell culture model for imprinting, discovery of a protein required for imprinted XCI, and the roles of two transcription factors in the switch between imprinted and random XCI in the early mouse embryo.

Small- and large-effect quantitative trait locus interactions underlie variation in yeast sporulation efficiency, pp. 1123 Kim Lorenz and Barak A. Cohen Sporulation efficiency in yeast is a complex trait controlled by alleles of both large and small effect. These investigators report that small-effect alleles differ depending on which large-effect alleles are present in the background, suggesting there are strong interactions between large- and small-effect alleles. Curiously, each large-effect allele had a nearby small effect allele, suggesting that variable alleles for a trait may cluster together in the genome.

Ancient admixture in human history, pp. 1065 Nick Patterson, Priya Moorjani, Yontao Luo, Swapan Mallick, Nadin Rohland, Yiping Zhan, Teri Genschoreck, Teresa Webster, and David Reich This article presents a suite of methods for learning about the history of genetic population mixtures. Application of the methods yielded the striking finding of a clear signal of admixture into northern Europe that likely reflects a history of admixture between Neolithic migrants and the indigenous Mesolithic population of Europe, consistent with recent analyses of ancient bones from Sweden and the genome sequence of the Tyrolean "Iceman".

Elucidating molecular networks that either affect or respond to plasma cortisol concentration in target tissues of liver and muscle, pp. 1109 Siriluck Ponsuksili, Yang Du, Eduard Murani, Manfred Schwerin, and Klaus Wimmers Cortisol has physiological implications for neurobiological, immune, and metabolic processes. This study addresses the genetics of variation in cortisol concentrations by integrating global gene expression and genome-wide association analyses of the level of expression quantitative trait loci detection with causality modeling. The study revealed genes that affect or respond to cortisol levels that are thus of interest in stress biology and animal breeding.

Pathways of genetic adaptation: Multistep origin of mutants under selection without induced mutagenesis in Salmonella enterica, pp. 987 Semarhy Quiones-Soto, Andrew B. Reams, and John R. Roth Bacterial populations plated on growth-limiting medium give rise to well-adapted mutant colonies that accumulate above a lawn of nongrowing cells. This has been attributed to stress-induced mutagenesis of nongrowing cells, but this article presents evidence that this behavior can result from pre-existing small-effect mutations that enable growth and adaptation under selection, with no change in mutation rate.

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Genetics Society of America's GENETICS journal highlights for November 2012

Recommendation and review posted by Bethany Smith

BOTHELL, Wash.--(BUSINESS WIRE)--

Seattle Genetics, Inc. (SGEN) today reported financial results for the third quarter and nine months ended September 30, 2012. The company also highlighted ADCETRIS (brentuximab vedotin) commercialization and clinical development activities, antibody-drug conjugate (ADC) pipeline and collaborator progress and upcoming milestones.

Through significant commercial, regulatory and clinical development efforts we are continuing to bring ADCETRIS to patients, expanding into other territories under our collaboration with Millennium/Takeda, and advancing the evaluation of ADCETRIS into earlier lines of therapy and other CD30-positive malignancies, said Clay B. Siegall, Ph.D., President and Chief Executive Officer at Seattle Genetics. At the upcoming American Society of Hematology (ASH) annual meeting in December, there will be more than a dozen data presentations by Seattle Genetics and investigators highlighting the evaluation of ADCETRIS in numerous lymphoma types. In addition, at ASH we will introduce our lead preclinical program, SGN-CD33A, which employs our next generation ADC technology, and we expect multiple data presentations by our ADC collaborators. The substantial progress with ADCETRIS and our other pipeline programs, as well as by our collaborators reinforces our ADC leadership position as we strive to change the way cancer is treated.

Recent ADCETRIS Highlights

ADC Collaborator Progress

Other Recent Highlights

Upcoming Milestones

Third Quarter and First Nine Months 2012 Financial Results

Total revenues in the third quarter of 2012 were $49.8 million, compared to $20.7 million in the third quarter of 2011. Total revenues for the nine month period ended September 30, 2012 were $146.9 million, compared to $45.9 million in 2011. Revenues in 2012 include ADCETRIS net product sales of $33.7 million in the third quarter and $102.8 million for the year to date. In addition, revenues include ADCETRIS royalty revenues of $1.7 million in the third quarter and $2.9 million for the year to date related to sales of ADCETRIS by Millennium under its international named patient program. Revenues also reflect amounts earned under the companys ADCETRIS and ADC collaborations totaling $14.5 million in the third quarter of 2012 and $41.1 million for the year to date.

Total costs and expenses for the third quarter of 2012 were $63.6 million, compared to $61.6 million for the third quarter of 2011. For the first nine months of 2012, total costs and expenses were $193.4 million, compared to $171.6 million in the first nine months of 2011. The planned increases in 2012 costs and expenses were primarily driven by ADCETRIS commercialization activities, cost of sales and research and development of the companys other ADC pipeline programs.

Link:
Seattle Genetics Reports Third Quarter 2012 Financial Results

Recommendation and review posted by Bethany Smith