Catholic Priest vs. Biologist
Gabrielle Cavanaugh and Brian Davis Genetic Engineering DHC 380 Fall 2012From:DHC380Views:2 0ratingsTime:07:49More inEducation

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Enter the rainy season and I turn to my inside chores...removing dried seeds from their seed pods.

And catching up on my reading ... checking up on what is new in the world of seeds. Namely, in the genetic engineering sector.

I stumbled onto an article about the difference between the GE and GMO designation. This author stated there is a definite difference between the two terms ... and she is right to a point.

Technically, GMO ... genetically modified organism ... refers to any plant that has been hybridized through pollen transference ... by humans, bees or any other natural process. So any cultivar such as 'Early Girl' tomato and Hosta 'June' are, in fact, GMOs.

'Early Girl' has been purposely bred by hand pollination to produce an early-ripening tomato. 'June' arrived on the gardening scene as a naturally-occurring sport of another hosta ... 'Halcyon'.

The GMO designation also holds true for those varieties that have been crossed within their own family ... broccoli with kale, apricot with plum, plum with cherry. These have all been done by humans using conventional pollen-transfer methods. Sounds a bit weird perhaps, but a perfectly plausible possibility in nature.

I do not think the pluerry ... the plum/cherry cross ... has been released to the market just yet. But the others are available.

In fact, cherry-plum hybrids have been around since the late 19th century. I found one reference listing over 20 different cultivars.

As for the apricot-plum hybrids ... they are called Pluots if the plant has predominantly plum parentage or Apriums if the parentage leans to the apricot side. Both are registered trademark names.

Then there is broccolini ... also known by several other names such as Asparation, brocoletti and Tenderstem. (The first and last are both trade registered names.) This is a natural cross between broccoli and kai-lan, a Chinese broccoli.

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Is there a difference between GE & GMO?

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-- Johns Hopkins geneticist part of 1000 Genomes Project

Newswise Completing the second phase of the 1000 Genomes Project, a multinational team of scientists reports that they have sampled a total of 1092 individuals from 14 different populations and sequenced their full genomes. The researchers described the feat as a collegial effort to equip biologists and physicians with information that can be used to understand the normal range of human genetic variants so that a patients disease genome can be interpreted in a broader context.

A report on the research, published online in Nature on Nov. 1 represents the culmination of five years of work, says Aravinda Chakravarti, Ph.D., professor of medicine and pediatrics and a member of the Institute of Genetic Medicine at the Johns Hopkins School of Medicine. Chakravarti helped to design the population genetics sampling plan.

The DNA donors in the study were not known to have any diseases, so the study gives us the genomic background we need for understanding which genetic variations are within the normal range, Chakravarti says. With this tool, scientists now have a standard with which they can compare the genome of someone with diabetes, for example. That in turn, Chakravarti says, will increase opportunities for understanding the disease and creating targeted, individualized treatment.

The selection of the 14 populations sampled was based on their ancient migratory history and their genetic relationship to the other populations studied. Within each population, healthy, unrelated donors were randomly chosen for blood draws. The blood samples were first transformed into cell lines that can be stored and grown indefinitely so that they will always be available for future studies. After cell lines were grown, the DNA was sequenced and added to a public database.

The first human genome to be sequenced, published in 2003, made clear that as much as 98.5 percent of human genetic material does not encode proteins, as had been thought. Scientists now know the role of some of the non-protein-coding regions and, although much of the genome remains a mystery, there is reason to suspect that at least some of it plays a part in the variability seen in disease susceptibility and prevalence.

The 1000 Genomes Project started at the beginning, with the whole genome and with no bias in the search for disease-related variants toward protein-coding genes, Chakravarti explains. Regulatory sequences and sequences we still dont understand were also catalogued, so this information widens the areas of the genome we can search when looking for disease-causing variants. Most of the genetics research done to date has begun with a disease or a protein that is known to be malfunctioning, followed by a hunt for the responsible genetic variants.

The genetic variations found in the populations analyzed were categorized by how frequently they appeared in the individuals tested. Variants seen in more than five percent of the samples were classified as common variants, while low-frequency variants appeared in 0.5 to five percent of individuals and rare variants in less than 0.5 percent of the samples.

The 14 populations sampled were divided into four ancestry groups: European, African, East Asian and American. As expected, most of the common variants had already been identified in previous studies, and their frequencies varied little between ancestry groups.

By contrast, 58 percent of the low-frequency variants and 87 percent of the rare variants were described for the first time in this study. Rare variants were sometimes twice as likely to be found within a particular population as in that populations broader ancestry group. Different populations also showed different numbers of rare variants, with the Spanish, Finnish and African-American populations carrying the greatest number of them.

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Scientific Team Sequences 1092 Human Genomes to Determine Standard Range of Human Genetic Variation

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ScienceDaily (Nov. 1, 2012) In one of the largest studies of its kind ever conducted, an international team of scientists has thrown new light on the genetic basis of the inflammatory bowel diseases (IBD). Crohn's disease and ulcerative colitis, the two most common forms of IBD, are chronic inflammatory digestive disorders.

Dr. John Rioux, researcher at the Montreal Heart Institute and Associate Professor of Medicine at the Universit de Montral, is one of the researchers who have identified 71 genetic regions newly associated with inflammatory bowel disease (IBD), increasing the total number discovered to date to 163, in one of the largest studies of its kind. Also, the study points out that these regions showed a striking overlap with those implicated in autoimmune diseases and in immune deficiencies. Even more surprising was the observation of a significant overlap with genetic regions controlling our response to microbial infections such as in the case of tuberculosis.

The research was published Nov. 1 in the journal Nature.

Moreover, these findings suggest that IBD results from overactive immune defence systems that evolved to fight off serious bacterial infections. In IBD, the body's immune system produces an ongoing inflammatory reaction in the intestinal tract that injures the intestinal wall, leading to diarrhea and abdominal pain. IBD patients typically require lifelong treatment with drug therapy, and often need surgery to repair tissue damage caused by the disease.

Common research

Up until this point, researchers have been studying Crohn's disease and ulcerative colitis separately. This study was based on the fact that there seems to be a vast amount of genetic overlap between the two disorders.

In the first step of the study, the researchers conducted a "meta-analysis" of 15 previous genomic studies of either Crohn's disease (CD) or ulcerative colitis (UC), the two most common forms of IBD, creating a large dataset that combined genetic information from some 34,000 individuals who took part in those studies. The results then formed part of a second meta-analysis that included data from new genome-wide scans of more than 41,000 DNA samples from CD/UC patients and healthy comparison subjects collected at 11 centers around the world by the International IBD Genetics Consortium.

"We have greatly expanded the map of genetic regions that are associated with IBD," agreed Dr. John Rioux, co-lead author of this study and chair of the Consortium, with Jeffrey Barrett of the Wellcome Trust Sanger Institute in Cambridge, England, lead author of the study. "Each of these regions only increases a person's chance of developing IBD by a fraction of a per cent and even taken together they cannot tell us who will or will not develop the disease. But they each tell a small story about the biology of this disorder, and by combining them we find biological pathways that, if disrupted, can lead to IBD."

Immune system: a major factor

Dr. Rioux and the international team of researchers also studied the activity of genes in their IBD regions in hundreds of different types of cells involved in the immune system. They found that certain cells tended to produce more of these IBD genes, including many that are involved in the body's first line defence against invasion. This illustrates that an immune response seems to be a major factor in IBD: when a bacterium is detected, these cells are not just activated, but become overactive.

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While better treatment options are being developed for patients with Crohn's, doctors still don't know what causes the disease. Russell Cohen, co-director of the Inflammatory Bowel Disease Center at the University of Chicago Medicine, provides an update on current research.

Copyright 2012 National Public Radio. For personal, noncommercial use only. See Terms of Use. For other uses, prior permission required.

IRA FLATOW, HOST:

Up next, a look at what current research tells us about what causes inflammatory bowel disease and the potentially simple way to treat it.

According to the Centers for Disease Control and Prevention, as many as a million-and-half people in the U.S. suffer from IBD, which includes Crohn's, a condition that occurs when a person's immune system inappropriately responds to harmless cells or bacteria and destroys healthy tissue. And to treat the disease, most patients take medications to suppress their immune systems, but some don't work very well, and they can have really awful side effects.

Well, now a couple of new studies suggests ways to more directly attack the disease, one involving genetically engineering bacteria which might be put into yogurt, and you could eat it in the yogurt and, you know, treat yourself that way. Russell Cohen is professor of medicine and co-director of the Inflammatory Bowel Disease Center at the University of Chicago. He joins us today from the Windy City.

Welcome to the program.

RUSSELL COHEN: Thank you very much.

FLATOW: Tell us about this bacteria, this new, genetically engineered bacteria.

COHEN: Well, you know, the bacteria themselves aren't new. They're a very common bacteria that you could find in yogurt or other products. But what these researchers did is they stuck some genes into the bacteria to make a particular type of protein that seems to protect the gut.

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Genetic Clues May Help Unravel Cause of Crohn's

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Pregnancy Faqs : How To Get Pregnant When You Have Pcos [How Do U Get Pregnant]
click here to learn more==)) yupurl.com Taking Birth Control While Pregnant. Effectiveness of Birth Control. Types of Birth Control. Iud. in-vitro-fertilization. Effective natural family planning is now available with any internet connection. Use iCycleBeads Online as natural birth control or to plan a pregnancy. pregnancy with anemia. Why do people say I just had a Newborn baby? If you just had a baby Im assuming its new. I #39;m not sure how u get pregnant with an old baby. 13 Like Comment Share. how to get pregnant. How does a women get pregnant-lessons about sex Runtime 3:55 Views 1023663. Title Pregnancy Tips : How to Get Pregnant Fast Runtime 1:03 Views 221842. pregnancy illnesses. women #39;s health. Getting Pregnant; TTC Cycle Buddies; Woman #39;s Health. do it yourself. Fertility Tips; Infertility Detoxification; Kidney . Kidney Overview; Cancer; Detoxification; Dialysis; Transplants; Malabsorption Syndrome . Malabsorption Syndrome; Pancreas . World Wide Sires, Ltd. is the world #39;s leading cattle genetics marketing organization representing the majority of the US Artificial Insemination Cooperatives.From:fatfatloseViews:0 0ratingsTime:06:30More inEntertainment

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The Intelligence Revolution (2007)
Visions of the Future: Episode 1: The Intelligence Revolution (2007) http://www.youtube.com Theoretical physicist and futurist Michio Kaku shows how, in the 21st century, artificial intelligence is going to become as ubiquitous as electricity, how robots with human-level intelligence may finally become a reality, and how we #39;ll even be able to merge our minds with machine intelligence. As the challenges and choices are literally mind-bending, Dr Kaku asks how far we will ultimately go. Episode 2: The Biotech Revolution (2007) http://www.youtube.com Leading theoretical physicist and futurist Michio Kaku looks at the revolution in genetics and biotechnology, which promises unprecedented health and longevity but also raises the spectre of a Frankenstein future of genetically engineered people. Will we, as transhumanists expect, evolve into a new species? Dr Kaku warns that we may end up in a world divided by genetic apartheid. Episode 3: The Quantum Revolution (2007) http://www.youtube.com Theoretical physicist and futurist Michio Kaku shows how quantum physics is giving mankind the power to manipulate the fundamental building blocks of matter. Science fiction ideas like the space elevator, teleportation, invisibility cloaks, or nanosized molecular machines might soon become a reality. But will we use our unprecedented scientific mastery wisely? Visions of the Future: Leading theoretical physicist and futurist Dr Michio Kaku explores the cutting edge science of today, tomorrow, and beyond. He ...From:Phobosuchus1Views:11 2ratingsTime:58:33More inScience Technology

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PAI Medical Laser Hair Therapy in Ottawa
Hair loss can have a devastating effect on many people. The reasons may be due to a variety of factors, from genetics, to hormonal to diet and environmental effects. Many people need to maintain a consistent image for work or pleasure, may need to update their image or do not want to suffer with hair loss. Although solutions vary from individual to individual, laser hair therapy may be an excellent solution for many. It is non-invasive and cool to the touch. Discuss this or any other hair loss solution with an expert at PAI Medical Group today, with a FREE and CONFIDENTIAL consultation, including a FREE hair and scalp analysis. Visit PAIHAIR.COM.From:PAImedicalViews:0 0ratingsTime:00:31More inEducation

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11-3 Exploring Mendelian Genetics (Part 1)
From:HHSBiologyViews:0 0ratingsTime:05:47More inFilm Animation

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11-3 Exploring Mendelian Genetics (Part 2)
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11-3 Exploring Mendelian Genetics (Part 2) - Video

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Mind Viruses Genetics
Date: 06 08 2009 To access the full archive and all the latest daily shows please visit and subscribe to this channel: http://www.youtube.com IF you would like to be notified the minute the daily show is released each day why not subscribe here http://www.youtube.com Also please subscribe on TWITTER heres the address or just click the twitter link on the right of the channel page twitter.com FACEBOOK heres the address or just click the facebook link on the right of the channel page http://www.facebook.comFrom:DiscoveryRadioShowsViews:0 0ratingsTime:02:34:33More inEducation

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Mind Viruses

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IRRI Pioneer Interview: Susan McCouch--A Juggling Act
Susan McCouch, an associate geneticist at the International Rice Research Institute (IRRI) in 1990-94 and currently professor of plant breeding and genetics at Cornell University, was truly a pioneer mdash;in more ways than one. She was an integral part of the team at Cornell that developed the first-ever molecular map of rice while, at the same time, being among the first female scientists to break the gender barrier in agricultural research. Back in 1985, when she applied to be a graduate student in Cornell #39;s plant breeding program, she was placed on probation because she was a female with a young child. Even so, during her July 2009 interview on the Cornell campus, she pointed out that, although she experienced difficulties and challenges as everyone does, she didn #39;t really believe that hers at both Cornell and IRRI were centered on gender issues. For the full transcript with links and photos, go to archive.irri.orgFrom:irrivideoViews:0 3ratingsTime:40:04More inEducation

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Race and Genetics - Wiki Article
Race (human classification) Category:Race (human classification) Race and Genetics - Wiki Article - wikiplays.org Original @ http All Information Derived from Wikipedia using Creative Commons License: en.wikipedia.org Author: Unknown Image URL: en.wikipedia.org Licensed under:Creative Commons ASA 3.0, This work is in the public domain in the United States. Author: Unknown Image URL: en.wikipedia.org Licensed under:Creative Commons ASA 3.0, This work is in the public domain in the United States. Author: Varoon Arya Image URL: en.wikipedia.org Licensed under:Creative Commons ASA 3.0, Licensed under the GNU Free Documentation License., GNU Free Documentation License, Creative Commons License Attribution-Share Alike 3.0 Unported This work is in the public domain in the United States. Author: Unknown Image URL: en.wikipedia.org Licensed under:Creative Commons ASA 3.0, This work is in the public domain in the United States. Author: Wobble Image URL: en.wikipedia.org Licensed under:This image is ineligible for copyright and therefore is in the public domain, because it consists entirely of information that is common property and contains no original authorship., This...From:WikiPlaysViews:0 0ratingsTime:47:36More inEducation

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Personality Genetics
Date: 08 02 2012 To access the full archive and all the latest daily shows please visit and subscribe to this channel: http://www.youtube.com IF you would like to be notified the minute the daily show is released each day why not subscribe here http://www.youtube.com Also please subscribe on TWITTER heres the address or just click the twitter link on the right of the channel page twitter.com FACEBOOK heres the address or just click the facebook link on the right of the channel page http://www.facebook.comFrom:DiscoveryRadioShowsViews:0 0ratingsTime:02:32:53More inEducation

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Personality

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Why I don #39;t want SRS and how that doesn #39;t make me less of a woman.
I #39;m really quite frustrated with this idea that trans women who do not want srs are in fact, men. It frustrates me because regardless of how loudly or how confindently you say that to me, you aren #39;t going to be able to convince anyone in my life that I #39;m a man. I have and will always be treated as a woman. Regardless of how you personally feel about my gender that is just something that won #39;t be changed. I also have issues with how people want to state that you aren #39;t a woman until you have SRS. Truth is, post op you still have male genetics and male blood flowing through your body. How much should we allow that to define our transition?From:Kitty KadaversViews:3 0ratingsTime:14:59More inPeople Blogs

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The Hidden Source Episode 25 -TROLL HIDDEN-
Myself ThatOneRebel playing some The Hidden Source! Nobody can see The Hidden only trained eyes can see him well! WATCH AS I MURDER EVERYONE AS THE HIDDEN MAHAAAHAHAHA The objective of The Hidden Source is that the humans aka IRIS must eliminate The Hidden to win vice versa for the Hidden but as the title says he is invisible and only is equipped with a knife capable of a one hit kill depending on server and only three grenades. The hidden has many abilities like taunting, super strength to ram objects into IRIS soldiers or be able to leap super high and hang on buildings. Lastly The Hidden can heal himself by eating bodies but only if they are stabbed to death not PIGSTICKED! (which is the one hit kill move) The IRIS are equipped with four weapons ranging from shotgun to rifle to SMG and a few options of equipment like senors to laser optics on your gun. Game is The Hidden Source which requires Half life 2 engine meaning you have to have Half Life 2 purchased already or another source game to run with STORYLINE In the early 1950s human genetics experimentation was taking its first, tentative steps. Amongst many other black projects, a team of British scientists working at an Infinitum Research experimental station stumbled across some remarkable phenomena involving DNA manipulation. This led to deeper research with dangerously unpredictable results, often leading to human patients losing their lives in irresponsible and immoral experiments. Time passed on, and by the mid ...From:ThatOneRebel55Views:0 0ratingsTime:14:02More inGaming

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Sam Sly Interviewing Luke Sly Pfizer Animal Genetics Employee
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Kimberly Banks Discusses The Different Genetic Testing Methods
Genetics counselor Kimberly Banks talks about the different methods for genetic testing. Patients usually have the option of either a blood test or mouth swab. Click Here Get The 15 Breast Cancer Questions To Ask Your Doctor http://www.breastcanceranswers.com Breast Cancer Answers is a social media show where viewers submit a question and get the answer from an expert. Submit your question now at, http://www.breastcanceranswers.com This information should not be relied upon as a substitute for personal medical advice, diagnosis or treatment. Use the information provided on this site solely at your own risk. If you have any concerns about your health, please consult with a physician.From:drjayharnessViews:1 0ratingsTime:02:26More inScience Technology

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Statement of Psychiatric Survivors Made at the 2012 Carter Center Symposium
This is a statement composed by 6 psychiatric survivors at the 2012 Carter Center Symposium on Social Inclusion. Dan Fisher reads it at the end of his panel presentation on Integrated Care and Wellness. The conference was highly focused on the disease model of emotional distress. This statement is about our concerns with the disease model approach and how it might be increasing stigma. Many people in the audience doubted our quote saying Thomas Insel of NIMH has admited there is no genetic evidence for mental illness. The exact quote is right here, from JAMA. 2010;303(19): "Where is the missing genetic signal for mental illness? The discovery that large (1 megabase) structural or copy number variants, such as deletions and duplications, are 10-fold more common in autism and schizophrenia is an important clue.3,4 Copy number variants are individually rare,sometimes restricted to a single family or developing de novo in an individual. Although "private mutations" are rare (reminiscent of Tolstoy #39;s dictum that "each unhappy family is unhappy in its own way"), they are in aggregate remarkably common, spread across vast expanses of the genome, and ultimately could explain more genetic risk than common variants. Although many of the genes implicated are involved in brain development, copy number variants do not appear to be specific for illnesses in the current diagnostic scheme. Within families, the same copy number variant may be associated with schizophrenia in one person ...From:Corinna WestViews:0 1ratingsTime:05:09More inNonprofits Activism

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What Can I Learn About My Family History Of Breast Cancer From Genetic Testing?
Genetics counselor Kimberly Banks talks about how genetic testing for breast cancer helps patients understand their risk. Click Here Get The 15 Breast Cancer Questions To Ask Your Doctor http://www.breastcanceranswers.com Breast Cancer Answers is a social media show where viewers submit a question and get the answer from an expert. Submit your question now at, http://www.breastcanceranswers.com This information should not be relied upon as a substitute for personal medical advice, diagnosis or treatment. Use the information provided on this site solely at your own risk. If you have any concerns about your health, please consult with a physician.From:drjayharnessViews:1 0ratingsTime:01:32More inScience Technology

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The Dark Side of the Double Helix: Andrew Hessel at TEDx Marin 2012
A fascinating inside look at the coming world of Synthetic Biology. Andrew Hessel is a futurist and catalyst in biological technologies, helping industry, academics, and authorities better understand the changes underway in life science. Trained in microbiology and genetics, Andrew has continually worked at the forefront of life science in industry and academia. He is faculty at Singularity University, where he co-chaired the Biotechnology and Bioinformatics track and now helps startup biotechnology companies organize and launch. He is also a fellow at the University of Ottawa, Institute for Science, Society, and Policy, and the founder of the world #39;s first cooperative biotechnology company, the Pink Army Cooperative, which is working to create open source therapies for cancer. Andrew has given dozens of invited talks related to synthetic biology, for groups that include Intel Inc., the FBI, and the United Nations. In thespirit of ideas worth spreading, TEDx is a program of local, self-organized events that bring people together to share a TED-like experience. At a TEDx event, TEDTalks video and live speakers combine to spark deep discussion and connection in a small group. These local, self-organized events are branded TEDx, where x = independently organized TED event. The TED Conference provides general guidance for the TEDx program, but individual TEDx events are self-organized.* (*Subject to certain rules and regulations)From:TEDxTalksViews:65 11ratingsTime:19:05More inScience Technology

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Anthropologies Of Modernity: Foucault, Governmentality, And Life Politics
ll4.me Anthropologies Of Modernity: Foucault, Governmentality, And Life Politics This book brings together a range of anthropological writings that are inspired by the French philosopher Michel Foucault and examine Foucaults contribution to current theories of modernity. Treats modernity as an ethnographic object by focusing on its concrete manifestations. Tackles issues of broad interest: from colonialism and globalization to war, genetics, and AIDS. Draws on work from North and South America, Europe, Africa, and South and Southeast Asia. Contributors include James Ferguson, Akhil Gupta, Aihwa Ong, Paul Rabinow, and Rayna Rapp. Publisher: Wiley-Blackwell Illustration: N Language: ENG Title: Anthropologies of Modernity: Foucault, Governmentality, and Life Politics Pages: 00288 (Encrypted PDF) On Sale: 2008-04-15 SKU-13/ISBN: 9780631228264 Category: Social Science : Anthropology - Cultural This book brings together a range of anthropological writings that are inspired by the French philosopher Michel Foucault and examine Foucaults contribution to current theories of modernity.From:michaelsims9866Views:0 0ratingsTime:00:14More inPeople Blogs

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Miscarriage Part V
Most likely cause: random genetic abnormalities. This is unfortunate but it can be totally normal. I will not know the exact cause of my miscarriage, so I #39;m sticking with the idea that it was random and happened because the world of genetics is extremely fragile.From:22ANewBeginning47Views:0 0ratingsTime:07:55More inPeople Blogs

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Miscarriage Part V - Video

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SALT LAKE CITY, Nov. 1, 2012 (GLOBE NEWSWIRE) -- Myriad Genetics, Inc. (MYGN) announced today that Peter D. Meldrum, President and CEO, is scheduled to present at the 2012 Credit Suisse Annual Healthcare Conference, at 9:30 a.m. Mountain Time on Thursday, November 15, 2012. The conference is being held at the Arizona Biltmore Resort & Spa in Phoenix, Arizona.

The presentation will be available to interested parties through a live webcast accessible on the investor relations section of Myriad's website at http://www.myriad.com.

About Myriad Genetics

Myriad Genetics is a leading molecular diagnostic company dedicated to making a difference in patients' lives through the discovery and commercialization of transformative tests to assess a person's risk of developing disease, guide treatment decisions and assess risk of disease progression and recurrence. Myriad's portfolio of molecular diagnostic tests are based on an understanding of the role genes play in human disease and were developed with a commitment to improving an individual's decision making process for monitoring and treating disease. Myriad is focused on strategic directives to introduce new products, including companion diagnostics, as well as expanding internationally. For more information on how Myriad is making a difference, please visit the Company's website: http://www.myriad.com

Myriad, the Myriad logo, BRACAnalysis, Colaris, Colaris AP, Melaris, TheraGuide, Prezeon, OnDose, Panexia and Prolaris are trademarks or registered trademarks of Myriad Genetics, Inc. in the United States and foreign countries. MYGN-G

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Myriad Genetics to Present at the 2012 Credit Suisse Annual Healthcare Conference

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Seattle Genetics (Nasdaq: SGEN) is a biotech company focused on the development of monoclonal antibody-based treatments for cancer. The company's antibody-drug conjugate, or ADC, technology treats cancer by sending in an antibody and an attached drug, which bind with cancer cells and stops cell division from the inside. The company currently has one drug, Adcertis, available for sale.

The company has a small field of competitors in the ADC realm. Leading that pack is ImmunoGen (Nasdaq: IMGN) with a targeted antibody payload, or TAP, technology that works similarly to ADC technology, and has led to the company striking several large partnerships to license it. Pfizer (NYSE: PFE) is in the early stages of developing its own ADC technology, even as it works on other drugs created with Seattle Genetics' technology that could become competitors for Adcertis. Medarex, a subsidiary of Bristol-Myers Squibb (NYSE: BMY) , has ADC technology and is developing monoclonal antibody drugs that could compete with Adcertis.

Here are three ways Seattle Genetics is working to expand its revenues past the currently narrow definitions of its sole drug on the market.

Geographic expansionAdcetris is a treatment that's been approved by the Food and Drug Administration for resistant forms of Hodgkin lymphoma and systemic anaplastic large cell lymphoma. The drug was approved last summer, but revenues have failed to ramp up sharply due in part to the domestic limitation of the drug.

Geographic expansion could be just around the corner. A European Commission decision is expected any day now, following a July committee recommendation, which would make the treatment available in 27 countries. Canadian approval is following right behind. Health Canada accepted the New Drug Submissionfor Adcetris back in May, and a decision is expected in early 2013.

Adcetris is a partnership between Seattle Genetics and Millennium, an oncology subsidiary of Takeda. The partnership grants Seattle Genetics the drug rights in the U.S. and Canada, and requires Millennium to pay up to $230 million in milestone payments plus a double-digit percentage of net sales from its global markets.

Expanded useExpanding the approved indications for Adcetris would also boost its revenues. Seattle Genetics' pipeline is half full of trials for new indications. There are two phase 3 trials that deserve closer attention.

The AETHERA trialtests Adcetris versus a placebo in patients at risk for residual Hodgkin lymphoma after an autologous stem-cell transplant. The study has a primary endpoint of progression-free survival, and secondary endpoints include overall survivability and safety. Data is expected in late 2013 or early 2014.

The ALCANZA trialcompares Adcetris to methotrexate or bexarotene in patients with specific mature type of t-cell lymphoma. This trial is still enrolling, so its data will come in behind ATHERA, which finished enrollment in late September.

There are also Adcetris trials in earlier stages. The potential indications include front-line HL when used in conjunction with chemotherapy, front-line HL in elderly populations, and non-lymphoma malignancies.

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