Like many of his fans, Chris McAlister hit hard times during the Great Recession.

A standout cornerback on Ravens defenses with Ed Reed and Ray Lewis, McAlister had an extremely underrated career. That alone couldnt save him in his post-football career.

Only three years after he played his final snap for the Baltimore Ravens, McAlister moved back in with his parents and depended on their money. This is his story.

RELATED: Ray LewisReveals the Most Painful Injury Hes Ever Had

The Baltimore Ravens personified what it meant to be a defense-first team.

Despite starting middling quarterbacks like Kyle Boller and Trent Dilfer, Baltimores defense carried them to the playoffs each year. The Ravens had players like Chris McAlister, an All-American cornerback from the University of Arizona, to thank for that feat.

The 10th overall pick in the 1999 NFL draft and son of former Patriots running back James McAlister, Chris McAlister created his own no-fly zone in Baltimore. McAlister snagged nine interceptions in his first two seasons, the second of which ended in a Super Bowl trophy.

The duo of McAlister and young linebacker Ray Lewis provided the Ravens with only one losing season from 1999-2004.

McAlister played in Baltimore from 1999-2008. He played two games for the New Orleans Saints in 2009, but the team cut him that December.

Two months later, Drew Brees and the Saints won Super Bowl 44.

RELATED: Marshal Yanda Retires as Top-5 Player in Ravens History

The fact Chris McAlister only made three Pro Bowls and earned one first-team All-Pro nod in 2003 may surprise some. McAlister was among the leagues top cornerbacks but never truly earned the respect he deserved.

Football-ReferencesApproximate Valuesystem measures McAlister was worth 88 AV in a Ravens uniform. That ranks eighth in Ravens history.

For comparison, Ray Lewis (221), Terrell Suggs (150), and Ed Reed (131) lead the pack. Lewis and Ed Reed, as well as offensive lineman Jonathan Ogden (129 AV), are in the Pro Football Hall of Fame; Suggs should generate a strong case when he is eligible.

The same goes for offensive lineman Marshal Yanda (111 AV) and defensive lineman Haloti Ngata (108 AV).

Besides McAlister, the only player in the Ravens top-8 who likely wont generate any Hall of Fame buzz in the near future is quarterback Joe Flacco. Although Flacco won Super Bowl 47, he was mostly average throughout his career.

RELATED: Browns Legend Bernie Kosar Had Just $44 When He WentBankrupt

Chris McAlister had an excellent NFL career. Things havent been so great since he hung up his cleats.

TMZ Sports obtained court documents in September 2011 which showed just how bad things were for McAlister. Two years after his final NFL down, McAlister pleaded with the judge to lower his $11,000 per month obligation in child support.

I have been unemployed since 2009. I have no income. I live in my parents home. My parents provide me with my basic living expenses as I do not have the funds to do so.

According to Spotrac, Chris McAlister earned $58.4 million in the NFL. That included a seven-year, $55 millioncontractextension he signed in 2004.

According to NESN, a post on a Baltimore Ravens emerged later that month where McAlister denied talking to TMZ. In their original story, TMZ cited McAlisters comments as coming from the court documents.

The message board post was later removed.

Like Sportscasting on Facebook. Follow us on Twitter @sportscasting19.

View post:
Chris McAlister Made Nearly $60 Million Then Moved Back in With His Parents - Sportscasting

Recommendation and review posted by Bethany Smith

IF YOUVE noticed more hair accumulating in your hairbrush in recent months, youre not alone. In July, when Californian dermatologist Dr Sandra Lee, better known as Dr Pimple Popper, posted a TikTok video talking about clients with sudden hair loss, it clocked up a quarter of a million views in 24 hours.

Google Trends reports that the search terms hair loss cure and is hair loss a symptom of Covid? have gone up 170 per cent and 120 per cent respectively over the last few weeks according to research performed by LOral.

And, taking a more scientific turn, the University of Nottingham has announced a study into the stress Covid-19 is doing to our physical and mental wellbeing by using strands of our hair for analysis.

Its apt, then, that August is National Hair Loss Awareness Month for women (and men) looking for reassurance right now.

There are different types and different causes of hair loss, says Anabel Kingsley, consultant trichologist at hair health specialists Philip Kingsley. One of the most common types in women is androgenetic alopecia, or hair thinning, which is slow, progressive and down to genetics, when follicles are predisposed to be sensitive to androgen male hormones.

What Anabels seen since lockdown began was such a huge increase in stress-related hair loss enquiries that the clinic began offering Zoom consultations, as did leading hair loss expert Simone Thomas, whose own experience had prompted her to open Simone Thomas Wellness in Bournemouth.

Hair is non-essential to physical survival so it will always be the first part of you to suffer when something is off-kilter, says Anabel. Stress can cause telogen effluvium (TE), a temporary, excessive, daily hair fall. One reason for this is that stress impacts nutrient absorption and may negatively affect the way you eat if you skip meals or reach for comfort foods of little nutritional value. This can result in increased hair shedding as nutritional deficiencies commonly cause hair loss.

Tellingly, this kind of hair fall after a stressful event can take three to six months to start showing. It happens when hairs are prematurely put into the shedding phase of their life cycle, a process triggered by the stress hormone cortisol. That less-than-six-months timeline takes us back to March and the beginning of lockdown. Usually, we tend to lose around 100 hairs of the 90-150,000 on our heads every day.

With TE, you can expect to see closer to 400 hairs shed daily, says Nicola Smart, consultant trichologist at the Smart Hair Clinic in Londons Vauxhall. This is a fairly significant increase that will occur diffusely across the scalp and in extreme cases, cause a temporary decline in density. For women with African hair types who are more likely to use protective styling over longer periods, it may appear as clumps of hair loss rather than diffuse or gradual shedding. But this is simply the 400 or so hairs that have accumulated over a certain period without being able to come loose.

As TE is usually temporary, for the four to nine months it will take for our hair to recover from any lockdown loss, there are ways to help encourage it to regrow healthy and strong

First, stock up on supplements that will help balance out any nutritional shortfall caused by stress or a poor diet. A firm favourite is Philip Kingsley Tricho Complex (1, below, 45 for 45 days supply, philipkingsley.co.uk) is packed with rebuilding biotin and L-lysine to support healthy growth and restore locks.

Start taking care of your scalp using potions formulated with ingredients that support new hair too. The Inkey List Caffeine Stimulating Scalp Treatment (2, 14.99, cultbeauty.co.uk) is a brilliant, budget-friendly overnight treatment to stimulate the scalps stem cells and encourage growth, while Grow Gorgeous Intense Hair Growth Serum (3, 45, growgorgeous.co.uk) stimulates the scalp with ingredients including caffeine, while also giving a noticeable thickness boost to lengths.

For an aromatic alternative, Alchemy Oils Amla Hair Remedy (4, 38, alchemyoils.co.uk) is rich in oils such as amla to strengthen follicles, coconut to protect from breakage, and shine-boosting lemon.

Carefully selecting shampoo and conditioner will help gently take care of your hair without placing any stress on it. Try Aveda Invati Advanced Exfoliating Shampoo (5, 25, aveda.co.uk) that helps prevent build-up of styling products or grime from blocking hair follicles as it detangles to prevent breakage, while the Thickening Conditioner (27) mimics hairs fibre-building blocks to create the impression and feel of more fullness.

And if youre suffering a sudden fallout, Krastase Genesis Ampoules Cure Anti-Chute Fortifiantes (6, 49, kerastase.co.uk) is formulated to tackle an intensive shed. One ampoule massaged daily on to the scalp for six weeks will help slow shedding and strengthen the link between the hair fibre and the root, aiming to return your crowning glory.

If you want to lengthen hair, use a protein-based range as this helps with strengthening. Focus on the scalp as well as the ends. Redken Extreme Length will promote hair growth from the scalp, while the sealer focuses on the ends of the hair. Strong hair also grows better. When hair is lacking nutrients, it is essential to put them back into the hair. Make sure you use a product that strengthens the hair with a natural protein, as well as ensuring full colour protection.

Ensure that you are using a product that helps to activate or stimulate the scalp as the scalp needs to be clear of any dirt/debris. Remember, when using products for thinning hair, your focus needs to be the scalp and not so much the hair. A good treatment will assist in cleansing the scalp area while stimulating the blood flow, which in turn, will assist in producing healthy hair.

Blow-drying and volumising products are great for making hair feel and look thicker and fuller. When creating volume, you need assistance and support. This can come from a volumising product. It is designed to make the hair feel physically thicker and will assist in getting volume from the root area. redken.co.uk, pureology.com

These dove-grey ultra-light track shorts by Perfect Moment tick the boxes for that 70s nostalgia trend and are perfect for park strolls or more dedicated workouts. 80, perfectmoment.com

Struggling with shine? Susanne Kaufmann has you covered, with her new face gel matte that reduces the appearance of pores and gives an instant velvety smooth appearance to the skin. Packed with plant-based hyaluron, its intensively moisturising too. 53, susannekaufmann.com

The Liberte bucket bag by Szane is a scene stealer, especially in chic French girl fave tan suede. Its produced in the EU using vegetable tanning, which is less polluting and more environmentally friendly than traditional methods. 205, sezane.com/en

If home colouring has left your hair struggling for condition, try Its A 10 Leave-In conditioning spray. Dubbed as a miracle leave-in spray, this contains sunflower seed, green tea extract and silk. 17.50, itsa10haircare.co.uk

Link:
Trends: The stress of the pandemic could be contributing to hair loss - Metro Newspaper UK

Recommendation and review posted by Bethany Smith

The mother of a transgender teenager is preparing to take legal action to prevent fertility doctors from destroying her dead daughters frozen sperm.

Louise Anderson, from Stirling, says she wants to honour her daughter Ellies wish to produce a grandchild, using her sperm, an egg donor and a surrogate carrier.

The 16-year-old died in Forth Valley hospital in July after falling ill. Her cause of death was described as unascertained.

Speaking to BBC Scotland, Anderson said: As a teenager she delayed hormone blockers to save her sperm to enable her to have her own biological children. She had made me promise that if anything were to happen to her, her children would be brought into the world.

I am going to do everything I can to honour her wishes not just for her but for anyone else who is caught in this position. It kind of sparked a little fire in my belly and I want to make her wishes come true.

Ellies sperm was frozen at Glasgow Royal Infirmary Fertility Clinic when she was 14 in the hope that one day she would have her own biological children. But the clinic has told her mother the sample cannot be retained.

Under UK human fertilisation rules, if Ellie was in a relationship at the time of her death, her partner would have had the right to request for her sperm to be retained. Her mother does not have that legal right.

Virgil Crawford, the solicitor acting for Anderson, said it was an unusual, interesting, important and complex legal issue.

What were trying to achieve would be to get an order from the court that Ellies mum would be entitled to make use of her sperm for the purpose that Ellie intended that being to create a genetic child of hers and a grandchild for Ms Anderson.

David Obree, a fellow in medical ethics at the University of Edinburgh, told the BBC that Ellies transgender status was irrelevant.

He said: The key question is, what did she intend the sperm to be used for? The question the court will need to look at is: did she specifically consent or request that her sperm be used by a third party?

A spokeswoman for NHS Greater Glasgow and Clyde, which runs the fertility clinic, said: We are sorry to hear about this young womans death and our sympathies are with her family.

Glasgow Royal Infirmary Assisted Conception Services is licensed and regulated by the Human Fertilisation and Embryology Authority. The storage of gametes (sperm) is managed in line with the Human Fertilisation and Embryology Act (1990) and complies with the consents provided by the donors.

Read more from the original source:
Mother in legal fight to save dead transgender daughters sperm - The Guardian

Recommendation and review posted by Bethany Smith

This detailed market study covers oral biologics marketgrowth potentials which can assist the stake holders to understand key trends and prospects in oral biologics marketidentifying the growth opportunities and competitive scenarios. The report also focuses on data from different primary and secondary sources, and is analyzed using various tools. It helps to gain insights into the markets growth potential, which can help investors identify scope and opportunities. The analysis also provides details of each segment in the global oral biologics market.

Click here to get sample of the premium report:https://www.quincemarketinsights.com/request-sample-67007?utm_source=SSK&utm_medium=NB&utm_campaign=SSK

According to the report, theoral biologics marketreport points out national and global business prospects and competitive conditions for oral biologics. Market size estimation and forecasts were given based on a detailed research methodology tailored to the conditions of the demand for oral biologics. The oral biologics market has been segmented by type (upper body sling, leg sling, whole body sling), by application (hospital, clinic, other). Historical background for the demand of oral biologics has been studied according to organic and inorganic innovations in order to provide accurate estimates of the market size. Primary factors influencing the growth of the demand Oral biologics have also been established with potential gravity.

Regional segmentation and analysis to understand growth patterns:

The market has been segmented in major regions to understand the global development and demand patterns of this market. North America, Europe, and Asia Pacific by region are estimated to dominate the oral biologics marketduring the forecast period. These regions have been market leaders for the overall healthcare sector in terms of technological developments and advanced medical treatments. Moreover, the government policies have been favorable for the growth of the healthcare infrastructure in these regions. North america and europe have an established healthcare infrastructure for product innovations and early adaptations. This is expected to drive the demand for oral biologics market.

Get ToC for the overview of the premium report:https://www.quincemarketinsights.com/request-toc-67007?utm_source=SSK&utm_medium=NB&utm_campaign=SSK

The US, Germany, France, UK, Canada, and Spain have been some the major markets in the region. Asia Pacific is estimated to register one of highest CAGR for Oral biologics marketduring the forecast period. This region has witnessed strategic investments by global companies to cater the growing demand in the recent years. China, Japan, India, South Korea, and Australia are amongst some of the key countries for oral biologics marketin the region. Other regions including middle east, are estimated to be emerging markets for oral biologics marketduring the forecast period.

This report provides:

1) An overview of the global market for oral biologics marketand related technologies.

2) Analysis of global market trends, yearly estimates and annual growth rate projections for compounds (CAGRs).

3) Identification of new market opportunities and targeted consumer marketing strategies for global Oral biologics market.

4) Analysis of R&D and demand for new technologies and new applications

5) Extensive company profiles of key players in industry.

The researchers have studied the market in depth and have developed important segments such as product type, application and region. Each and every segment and its sub-segments are analyzed based on their market share, growth prospects and CAGR. Each market segment offers in-depth, both qualitative and quantitative information on market outlook.

Speak to analyst before buying this report:https://www.quincemarketinsights.com/enquiry-before-buying/enquiry-before-buying-67007?utm_source=SSK&utm_medium=NB&utm_campaign=SSK

Market Segmentation:

By Drug Class:

By Disease Indication:

By Distribution Channel:

By Region:

North AmericaOral Biologics Market

EuropeOral Biologics Market

Asia PacificOral Biologics Market

Middle East & AfricaOral Biologics Market

South AmericaOral Biologics Market

Major Companies:Novo Nordisk A/S, Biocon Limited, Oramed Pharmaceuticals, Inc., Rani Therapeutics, Entera Bio Ltd., Allergan plc, Emisphere Technologies, Inc., Enteris BioPharma, Inc., Chiasma, Inc., and Allena Pharmaceuticals, Inc.

Years Covered in the Study:

Historic Year:2017-2018

Base Year:2019

Estimated Year:2020

Forecast Year: 2028

Objectives of this report:

Reasons to Buy This Report:

Customization:

This study is customized to meet your specific requirements:

ABOUT US:

QMI has the most comprehensive collection of market research products and services available on the web. We deliver reports from virtually all major publications and refresh our list regularly to provide you with immediate online access to the worlds most extensive and up-to-date archive of professional insights into global markets, companies, goods, and patterns.

Contact:

Quince Market Insights

Ajay D. (Knowledge Partner)

Office No- A109

Pune, Maharashtra 411028

Phone: US +1 208 405 2835

Email:[emailprotected]

Web: http://www.quincemarketinsights.com

See the original post here:
ORAL BIOLOGICS MARKET TO WITNESS ROBUST EXPANSION THROUGHOUT THE FORECAST PERIOD 2016-2028 The News Brok - The News Brok

Recommendation and review posted by Bethany Smith

CONTESSA Achieved Primary Endpoint Tesetaxel Plus a Reduced Dose of Capecitabine Significantly Improved Progression-free Survival (PFS) Versus the Approved Dose of Capecitabine Alone (Hazard Ratio=0.716; p=0.003)

Median PFS Was 9.8 Months for Tesetaxel Plus a Reduced Dose of Capecitabine Versus 6.9 Months for the Approved Dose of Capecitabine Alone, an Improvement of 2.9 Months

Company to Host Conference Call Today at 8:30 a.m. ET

Odonate Therapeutics, Inc. (NASDAQ: ODT), a pharmaceutical company dedicated to the development of best-in-class therapeutics that improve and extend the lives of patients with cancer, today announced positive top-line results from CONTESSA, a Phase 3 study of tesetaxel in patients with metastatic breast cancer (MBC).

CONTESSA is a multinational, multicenter, randomized, Phase 3 study of tesetaxel, an investigational, orally administered taxane, in patients with MBC. CONTESSA is comparing tesetaxel dosed orally at 27 mg/m2 on the first day of each 21-day cycle plus a reduced dose of capecitabine (1,650 mg/m2/day dosed orally for 14 days of each 21-day cycle) to the approved dose of capecitabine alone (2,500 mg/m2/day dosed orally for 14 days of each 21-day cycle) in 685 patients randomized 1:1 with human epidermal growth factor receptor 2 (HER2) negative, hormone receptor (HR) positive MBC previously treated with a taxane in the neoadjuvant or adjuvant setting. Capecitabine is an oral chemotherapy agent that is considered a standard-of-care treatment in MBC. Where indicated, patients must have received endocrine therapy with or without a cyclin-dependent kinase (CDK) 4/6 inhibitor. The primary endpoint is progressionfree survival (PFS) as assessed by the Independent Radiologic Review Committee (IRC). The secondary efficacy endpoints are overall survival (OS), objective response rate (ORR) as assessed by the IRC and disease control rate (DCR) as assessed by the IRC. CONTESSA is being conducted at 180 investigational sites in 18 countries in North America, Europe and Asia.

CONTESSA met the primary endpoint of improved PFS as assessed by the IRC. Median PFS was 9.8 months for tesetaxel plus a reduced dose of capecitabine versus 6.9 months for the approved dose of capecitabine alone, an improvement of 2.9 months. The risk of disease progression or death was reduced by 28.4% [hazard ratio=0.716 (95% confidence interval: 0.573-0.895); p=0.003] for tesetaxel plus a reduced dose of capecitabine versus the approved dose of capecitabine alone.

Tesetaxel plus capecitabine was associated with a manageable side effect profile consistent with findings from previous clinical studies. Grade 3 treatment-emergent adverse events (TEAEs) that occurred in 5% of patients were: neutropenia (71.2% for tesetaxel plus capecitabine vs. 8.3% for capecitabine alone); diarrhea (13.4% for tesetaxel plus capecitabine vs. 8.9% for capecitabine alone); hand-foot syndrome (6.8% for tesetaxel plus capecitabine vs. 12.2% for capecitabine alone); febrile neutropenia (12.8% for tesetaxel plus capecitabine vs. 1.2% for capecitabine alone); fatigue (8.6% for tesetaxel plus capecitabine vs. 4.5% for capecitabine alone); hypokalemia (8.6% for tesetaxel plus capecitabine vs. 2.7% for capecitabine alone); leukopenia (10.1% for tesetaxel plus capecitabine vs. 0.9% for capecitabine alone); and anemia (8.0% for tesetaxel plus capecitabine vs. 2.1% for capecitabine alone).

Adverse events resulting in treatment discontinuation in 1% of patients were: neutropenia or febrile neutropenia (4.2% for tesetaxel plus capecitabine vs. 1.5% for capecitabine alone); neuropathy (3.6% for tesetaxel plus capecitabine vs. 0.3% for capecitabine alone); diarrhea (0.9% for tesetaxel plus capecitabine vs. 1.5% for capecitabine alone); and hand-foot syndrome (0.6% for tesetaxel plus capecitabine vs. 2.1% for capecitabine alone). Treatment discontinuation due to any adverse event occurred in 23.1% of patients treated with tesetaxel plus capecitabine versus 11.9% of patients treated with capecitabine alone.

Grade 2 alopecia (hair loss) occurred in 8.0% of patients treated with tesetaxel plus capecitabine versus 0.3% of patients treated with capecitabine alone. Grade 3 neuropathy occurred in 5.9% of patients treated with tesetaxel plus capecitabine versus 0.9% of patients treated with capecitabine alone.

Story continues

While overall survival (OS) data are not mature, a recent interim analysis indicated the absence of an adverse effect on OS. A final analysis of OS is expected to occur in 2022.

"Tesetaxel represents a potential important clinical advance for patients with metastatic breast cancer," said Joyce OShaughnessy, M.D., Celebrating Women Chair in Breast Cancer Research, Baylor University Medical Center, Texas Oncology and Chair, Breast Cancer Research, US Oncology, and Co-Principal Investigator of CONTESSA. "There remains a significant unmet medical need for novel therapies that offer quality-of-life advantages for patients with metastatic breast cancer. This need is underscored by a recent update to the National Comprehensive Cancer Network guidelines recommending oral oncolytics that can reduce the frequency of clinic visits."

"The clinically meaningful PFS improvement observed in CONTESSA, along with once-every-three-week oral dosing and low rates of clinically significant hair loss and neuropathy, could make tesetaxel an important new treatment option for patients with metastatic breast cancer," said Andrew Seidman, M.D., Attending Physician, Breast Medicine Service, Department of Medicine, Medical Director, Bobst International Center, Memorial Sloan Kettering Cancer Center and Professor of Medicine, Weill Cornell Medical College, and Co-Principal Investigator of CONTESSA.

"We would like to thank all of the investigators, study team personnel, and especially the patients and their caregivers who made CONTESSA possible," said Kevin Tang, Chief Executive Officer of Odonate. "We look forward to working closely with global regulatory authorities to make tesetaxel available to patients with metastatic breast cancer. We plan to submit a New Drug Application for tesetaxel to the FDA in mid-2021."

The Company plans to submit the results of CONTESSA for presentation at an upcoming medical meeting.

Conference Call Information

Odonate will host a conference call today, Monday, August 24, 2020, at 8:30 a.m. ET. To participate in the call, please dial (866) 300-4090 (domestic) or (636) 812-6660 (international) and use conference ID 2881009.

About Tesetaxel

Tesetaxel is an investigational, orally administered chemotherapy agent that belongs to a class of drugs known as taxanes, which are widely used in the treatment of cancer. Tesetaxel has several pharmacologic properties that make it unique among taxanes, including: oral administration with a low pill burden; a long (~8day) terminal plasma half-life in humans, enabling the maintenance of adequate drug levels with relatively infrequent dosing; no history of hypersensitivity (allergic) reactions; and significant activity against chemotherapy-resistant tumors. In patients with metastatic breast cancer, tesetaxel was shown to have significant, single-agent antitumor activity in two multicenter, Phase 2 studies. Tesetaxel currently is the subject of three studies in breast cancer, including a multinational, multicenter, randomized, Phase 3 study in patients with metastatic breast cancer, known as CONTESSA.

About CONTESSA

CONTESSA is a multinational, multicenter, randomized, Phase 3 study of tesetaxel, an investigational, orally administered taxane, in patients with metastatic breast cancer (MBC). CONTESSA is comparing tesetaxel dosed orally at 27 mg/m2 on the first day of each 21-day cycle plus a reduced dose of capecitabine (1,650 mg/m2/day dosed orally for 14 days of each 21-day cycle) to the approved dose of capecitabine alone (2,500 mg/m2/day dosed orally for 14 days of each 21-day cycle) in 685 patients randomized 1:1 with human epidermal growth factor receptor 2 (HER2) negative, hormone receptor (HR) positive MBC previously treated with a taxane in the neoadjuvant or adjuvant setting. Capecitabine is an oral chemotherapy agent that is considered a standard-of-care treatment in MBC. Where indicated, patients must have received endocrine therapy with or without a cyclin-dependent kinase (CDK) 4/6 inhibitor. The primary endpoint is progression-free survival (PFS) as assessed by an Independent Radiologic Review Committee (IRC). The secondary efficacy endpoints are overall survival (OS), objective response rate (ORR) as assessed by the IRC, and disease control rate (DCR) as assessed by the IRC.

About Odonate Therapeutics, Inc.

Odonate Therapeutics, Inc. is a pharmaceutical company dedicated to the development of best-in-class therapeutics that improve and extend the lives of patients with cancer. Odonates initial focus is on the development of tesetaxel, an investigational, orally administered chemotherapy agent that belongs to a class of drugs known as taxanes, which are widely used in the treatment of cancer. Odonates goal for tesetaxel is to develop an effective chemotherapy choice for patients that provides quality-of-life advantages over current alternatives. To learn more, please visit http://www.odonate.com.

Forward-looking Statements

This press release contains "forward-looking statements" as defined by the Private Securities Litigation Reform Act of 1995. We caution investors that forward-looking statements are based on managements expectations and assumptions as of the date of this press release and involve substantial risks and uncertainties that could cause the actual outcomes to differ materially from what we currently expect. These risks and uncertainties include, but are not limited to, those associated with: expectations regarding the outcome of CONTESSA, our Phase 3 study of tesetaxel in patients with metastatic breast cancer; expectations regarding the enrollment, completion and outcome of our other clinical studies; expectations regarding the timing for our planned New Drug Application submission for tesetaxel and our ability to obtain regulatory approval of tesetaxel; the unpredictable relationship between preclinical study results and clinical study results; and other risks and uncertainties identified in our filings with the U. S. Securities and Exchange Commission. Forward-looking statements in this press release apply only as of the date made, and we undertake no obligation to update or revise any forward-looking statements to reflect subsequent events or circumstances.

View source version on businesswire.com: https://www.businesswire.com/news/home/20200824005197/en/

Contacts

Odonate Therapeutics, Inc.John LemkeyChief Operating Officer(858) 731-8188jlemkey@odonate.com

Original post:
Odonate Therapeutics Announces Positive Top-line Results from CONTESSA, a Phase 3 Study of Tesetaxel in Patients with Metastatic Breast Cancer - Yahoo...

Recommendation and review posted by Bethany Smith

MANY people have been struggling to sleep during the coronavirus pandemic due to increased levels of stress.

Around six in 10 Brits struggle to hit the hay successfully, according to a recent study from King's College London.

6

It also found that 63 per cent of people say their sleep has gotten worse since March.

As well as this a recent report also suggested that a third of Brits have put weight on during lockdown, as gyms closed their doors due to the virus.

But could your diet be the key to a good night's sleep, and are there foods that can help you nod off and lose weight?

Speaking to The Sun experts have revealed the seven foods that can help you drift off without piling on the pounds.

Foods that help calm and relax the body and don't disturb the gut are great for people who are struggling to sleep, Karl Kristian founder and health and wellbeing expert at New Nordic told The Sun.

He said: "Nuts such as walnuts and almonds that are also a source of melatonin that is a hormone that helps regulate your sleep."

Despite the fact that nuts are high in fat and in calories, various studies have shown that they are not linked to weight gain.

One study found that people who ate two or more portions of nuts a week were 31 per cent more likely to keep the weight off than those who consumed no nuts at all.

6

Most of us are used to tucking into a hot chocolate before bed or even a chilled glass of wine in the evening, but Karl says that the best way to get a good night's sleep is to drink a herbal tea before bed.

He said: "Chamomile tea contains antioxidants that help relieve stress and anxiety by reducing inflammation and soothing your muscles which is why it is often recommended for those that struggle with insomnia."

Karl added that green tea, ginger, coffee and yerba mate are all great beverages that can help with your metabolism and therefore can help you maintain a healthy weight.

"As well as this, apple cider vinegar has been used for centuries becoming popular as a supplement to help weight management and digestion.

"Science is now reinforcing these concepts with studies showing that it may play a role in helping to maintain a healthy blood sugar balance, as well as helping you feel full more quickly", he added.

6

Nutritionist Susan Alexander, who works alongside Unbeelievable Health said a diet in magnesium rich foods can help if you're struggling to sleep.

She said: "Magnesium has been shown to help you relax, so try eatingrichsources ofmagnesiumsuch as greens, dry beans, whole grains and low-fat dairy products.

"Tryptophanis an amino acid that's believed to inducesleep, as it isa precursor to thesleep-inducing chemicals serotonin and melatonin.

"Tryptophancan be found in yoghurt, milk, oats, bananas, dates, poultry, eggs and peanuts."

Foods such as greens help you stay fuller for longer and also contribute to your five-a-day.

Low fat dairy products can also help if you're trying to lose weight as their calorie and fat count are lower than the "full fat" versions.

Nutritionist Donia Hilal added: "Foods rich in magnesium are another way to relax your muscles and mind before bed.

"You can find magnesium in leafy green vegetables such as spinach, nuts and avocado."

6

We have heard many times that the Mediterranean diet is good for your health - but it could also help you sleep, according to Dr Michael Mosely, who devised the Fast800 diet plan.

He said: "A traditional Mediterranean diet is rich in oily fish, veg, legumes and olive oil and little in the way of sugary snacks.

"Eating this way will help improve both your mood and your weight, something we will all need to consider as we become increasing sedentary during self-isolation."

Four top tips to get a good night's sleep

Nutritionist Lisa Borg said there are four things everyone can do to help them get forty winks.

He said that focusing on a diet included legumes will help you stop craving sugary snacks which is turn leads to poor sleep and high levels of sleep deprivation.

Dr Mosely added: "You should stop eating altogether at least three hours before bed.

"Experts think this helps us keep our body temperatures down. As we get to our bedtimes, our body temperature starts to drop which helps trigger sleep.

"When a late-night snack hits your stomach, your body starts breaking it down and absorbing it.

"This increases gut activity and your core temperature will stay high, so dont bother with the pre-bed hot chocolate or glass of milk. These are common myths.

Oily fish is a great source of vitamin D, protein, some B vitamins and selenium.

It's also rich in omega 3 fatty acids, which come with a whole host of health benefits.

The main benefit of oily fish is that it's been shown to reduce the risk of heart attacks, strokes and other cardiovascular diseases.

Speaking to The Sun Lisa Borg, nutritionist atPulseLight Clinic said you should aim to consume around three pieces of oily fish a day to help your weight loss efforts and said that keeping a balanced diet will also help you drift off easier each night.

"If one wakes up feeling really tired after a good nights sleep it suggests hormonal imbalances may be present.

"Follow a diet to balance blood glucose levels and make sure you exercise for at least 30 minutes everyday."

By opting for oily fishes you can reduce the sugar levels in meals as oily fish already has a lot of flavour so doesn't usually require further seasonings which some times contain added sugars.

6

She added: "Sleep is essential in controlling appetite and food choices. The tired individual will crave sugary foods for a quick energy fix.

"Insufficient sleep results in a higher production of the hunger hormone Ghrelin and subsequently an excess intake of calories.

"Balance meals and snacks ensuring they provide a carbohydrate, a protein and a healthy fat. This helps to slow down the release of glucose and therefore reduces insulin release and keeps one satisfied for longer."

If you have become dependent on a sweet treat in the evening opting for products with no added sugars are a good alternative.

Yogurts won't upset the stomach and products such as Perfect World Ice Cream and Halo which are under 400 calories a tub are great if you want to have a treat without piling on the pounds.

Supermarkets such as Asda, Sainsbury's and Waitrose also do their own low calorie ice creams.

Some of these products - many of which contain nuts, are also high in fibre which Lisa recommends.

Donia Hilal, nutritionist atpersonalised.co said while Turkey may not be at the top of everyone's shopping list - it's a great food for sleep and weight loss.

Speaking to The Sun she said: "It is rich in an amino acid called tryptophan which is used by the body to increase melatonin levels - our sleep hormone.

"You can incorporate turkey breast into your dinner to help naturally boost melatonin levels in the body."

Turkey is also high in protein and is great to add to salads and pastas.

6

Emily Rollason, nutritionist for Holland & Barrett added: "Protein is whats known as a macronutrient, meaning the body requires a lot of it to stay healthy.Protein is a not-so-secret weapon when it comes to weight loss.

"The main reason for this is protein is satiating which means it makes you fuller for longer.

"For adults, the general daily requirement is 0.6g of protein per kilogram bodyweight."

For people who aren't big fans of turkey and for those who are vegetarian or vegan she suggested a protein shake with almond or other nut milk.

QUEEN BEEBody confident Honey Ross shows off her glam lifestyle & exotic bikini selfies

FOOD FIGHTMum gets lunchbox shamed over a sandwich as people say a toddler could do better

Exclusive

PACK IT INI'm a mum-of-three & spend 10 a week on 15 packed lunches using Aldi bargains

FAN-TASTICMum reveals easy washing rack hack to get clothes to dry in half the time

WEDDED dISSInside Vogue & Brian McFadden's marriage that made her 'bit sick in my mouth'

NO KIDDINGMum bags 30 food shop for 3 after struggling to make ends meet before payday

While Donia said there are no specific foods that will help with weight loss - the most important thing is to make sure that you are consuming less calories than you are burning throughout the day.

She did however say that cherries could be a great addition to your diet.

"Cherries are naturally rich in melatonin, the hormone which helps regulate your sleep.

"Try opting for overnight oats with cherries before bed to help you doze of naturally", she added.

Emily added: "Cherry-tart cherries such as Montmorency Cherries have naturally high levels of a hormone that regulate the bodys circadian rhythm (the sleep/ wake cycle) and induces sleep - melatonin.

"Some studies have shown that those taking cherry juice had improved sleep and slept for longer that those not taking this."

Read more here:
The 7 best foods to help you sleep AND lose weight at the same time - The Sun

Recommendation and review posted by Bethany Smith

STARTING the day with a tea or coffee is part of most people's morning ritual.

When it comes to tea and coffee, Brits drink around 195 million cups of these caffeine-filled infusions every day.

The UK Tea & Infusions Association states that Brits gulp 100 million cups of tea and 95 million cups of coffee.

Earlier this week experts revealed that drinking two cups of coffee a day could slash your risk of dying from liver cancer by 46 per cent.

For those of us who can't get through the day without a caffeinated beverage this is good news.

Despite this a separate study published this week also found that drinking any coffee or tea during pregnancy puts your unborn baby at risk.

Many experts were quick to slam the study and claimed that pregnant women do not have to eliminate coffee from their diet completely.

While most of us enjoy a brew in the morning, what do caffeinated drinks actually do to us?

Experts have explained the journey these drinks take through the body with a timetable as a guide as to when caffeinated drinks take effect.

The alarm goes off and you're ready for another day - but not until you've had your first drink of the day.

Whether it's coffee or tea, your chosen beverage can often help you face the day with a sense of renewal.

Speaking to The Telegraph, Thomas Sanders, a professor of nutrition and dietetics at Kings College London said coffee usually sticks around in the system for around five to six hours.

He stressed that there is quite a lot of variation in the individual response to coffee, and said that this will impact how that first cup is broken down in the body.

3

While most of us think we need a caffeinated drink to get through the morning rush, Prof Sanders said that this is actually just a placebo effect.

He said if your usual routine involves putting on the kettle first thing then it's likely you've tricked your mind into thinking that you need the drink to conquer the day.

He said: "To feel the effects of coffee, youve got to let it absorb into the bloodstream.

"What youre feeling at this stage is only likely to be a psychological effect."

3

Now you're feeling pumped as the caffeine has been absorbed into your blood stream.

You're heart rate will be up and you will feel a alert as the drink causes adrenaline to be released.

When we consume caffeine it tells our hormone control centre - the pituitary gland that there's an emergency.

This triggers the "fight or flight" mode. Previous studies found that this excited state can often make us feel more emotionally charged than we usually would - and could help us power through those morning emails.

Researchers at Carnegie Mellon University found that caffeine can stimulate the heart and cause adrenaline spikes.

You've had your coffee and now you need to go the loo.

Coffee and tea is known to have a diuretic effect of the body.

While drinking just one cup won't leave you rushing to find the nearest toilet - more than one could cause an increase in urine production.

Despite this - these drinks don't increase levels of dehydration, the Mayo Clinic states.

Coffee, whether it's decaf or not, has an impact on your bowels.

Around an hour and a half after your first cup it's likely you'll need to go the loo.

Some people who have sensitive bowels might want to avoid black coffee as this could cause irritation.

Research has previously shown that caffeine makes the colon 60 per cent more active than water and 23 per cent more active than decaf coffee.

Speaking to The Sun, one expert said that if your stomach struggles with hot coffee, then drinking it cold might be the way ahead.

Theo Garcia, co-founder ofSolo Coffee said a cold brew is 60 per cent less acidic than hot coffee - meaning it's easier on the stomach, especially for people who have irritable bowel syndrome (IBS).

3

He said: "Due to the lower acidity, the coffee is a lot smoother and tastes naturally sweet, meaning consumers can avoid adding milk and sugar to boost flavour.

"Another benefit is that cold brew has a higher level of caffeine due to the longer brewing process, and has proven to be beneficial to exercise performance, mental and physical health."

The big meetings are out of the way, the kids are washed and fed and now you're feeling a bit low.

This is because the effects of caffeine are starting to wear off and your body is ready for its next fix.

You might start to feel tired or irritable and you could even suffer from headaches.

You can avoid a caffeine slump by not drinking on an empty stomach, staying hydrated and spreading out your caffeine consumption.

That run to the tea room has started to look even more appealing.

Several hours after drinking caffeine your body will start to crave more.

FOOD FIGHTMum gets lunchbox shamed over a sandwich as people say a toddler could do better

QUEEN BEEBody confident Honey Ross shows off her glam lifestyle & exotic bikini selfies

FAN-TASTICMum reveals easy washing rack hack to get clothes to dry in half the time

Exclusive

PACK IT INI'm a mum-of-three & spend 10 a week on 15 packed lunches using Aldi bargains

NO KIDDINGMum bags 30 food shop for 3 after struggling to make ends meet before payday

WEDDED dISSInside Vogue & Brian McFadden's marriage that made her 'bit sick in my mouth'

Prof Sanders said that if these drinks are part of your normal routine then it's likely your body will be expecting more of it.

But experts have warned us to avoid reaching for these drinks in the afternoon, and instead suggest opting for herbal teas or decaf options.

This is because consuming caffeine later on in the day means some of us might struggle to sleep.

Being that a lack of sleep is why most of us reach for the coffee in the first place it's probably best to avoid coffee in the afternoons and evenings.

More:
This is what happens to your body when you take a sip of caffeine - The Sun

Recommendation and review posted by Bethany Smith

The three keys to a genuine weight loss (fat loss ) plan are diet, exercise, and metabolism correction. All three keys interconnect one will not work without the other. Your metabolism is the most powerful of all the three keys it is the switch that controls everything else. In most people this switch is off.

Metabolism problems such as slow thyroid, type 2 diabetes, sluggish liver, hormone imbalances, PCOS, endometriosis, infertility, and digestive problems such as constipation, IBS, and diverticulitis will limit or stop your weight loss, no matter how much dieting or exercise you do.

System 10 scientifically combines food and exercise to fix your metabolism for amazing weight loss and toning. You also get great energy, better sleep, and other health benefits all connected to metabolism problems.

This is a total plan of normal food, exercise, superb information, and motivation. It includes:

A metabolism analysis to identify the weak areas within your system.

Seven-day food plans that tell you exactly what to have for breakfast, lunch, dinner, and snacks, all nutritionally balanced and portion specific to each individual.

The system uses normal, everyday, foods. Eating well has never been so easy.

You get treat calories every day and a weekly alcohol allowance.

Simple weekly exercise covering cardio and toning.

Choose from a 10-week or six-week in-clinic one-to-one programme, or the very successful four-week home plan which includes twice weekly weigh-ins plus a weekly private phone consultation.

Contact Grace on 087 1727882 for all information and starting dates.

The System 10 plan includes:

An analysis of your metabolism.

Dietician designed highly balanced food plans of normal, natural foods no pills, bars, or shakes.

An exercise plan [home walk, jog, or bike] or gym plan including toning.

Nutritional supplement recommendations to rapidly repair your system.

Private weigh-ins, motivational tips, and support throughout the programme.

System 10 guarantees that every pound you lose is a pound of fat [you do not lose water or muscle like most plans]. You will lose 2-3lb every week and, because the programme is designed to speed up your metabolism, you will keep the weight off when you finish your plan. Programmes are available for men and women.

Contact Grace on 087 1727882 for an appointment. Clinics are located in Salthill, Oranmore, and Clifden.

More:
Lose up to two stone in ten weeks - Galway Advertiser

Recommendation and review posted by Bethany Smith

The research report on the global Genetic Testing Market offers an all-encompassing analysis of recent and upcoming states of this industry which also analyzes several growth strategies for market growth. The Genetic Testing report also focuses on the comprehensive study of the industry environment, and industry chain structure extensively. The Genetic Testing report also sheds light on major factors including leading vendors, growth rate, production value, and key regions.

Request for a sample report here @:

https://www.reportspedia.com/report/life-sciences/global-genetic-testing-market-report-2020-by-key-players,-types,-applications,-countries,-market-size,-forecast-to-2026-(based-on-2020-covid-19-worldwide-spread)/68234#request_sample

Top Key Players:

HI GeneRegulatoryAnnoroadSinoGenoMaxGenePlanetCounsyl, Inc.RepconexNatera, IncBiomarkerGeeppine360Jiyin23andMe, IncCapitalBioBiomedlabGene by GeneUnited GeneGeneDxFind Bio-TechAiyin GeneCourtagen Life SciencesAgenGeneTestsAsper BiotechPathway GenomicsNovogeneBGIGene KangBerry GenomicsAijiyin

Genetic Testing Market Fragment by Areas, regional examination covers

United States, Canada, Germany, UK, France, Italy, Russia, Switzerland, Sweden, Poland, , China, Japan, South Korea, Australia, India, Taiwan, Thailand, Philippines, Malaysia, Brazil, Argentina, Columbia, Chile, Saudi Arabia, UAE, Egypt, Nigeria, South Africa and Rest of the World.

The Genetic Testing Market report introduces the industrial chain analysis, downstream buyers, and raw material sources along with the correct comprehensions of market dynamics. The Genetic Testing Market report is articulated with a detailed view of the Global Genetic Testing industry including Global production sales, Global revenue, and CAGR. Additionally, it offers potential insights about Porters Five Forces including substitutes, buyers, industry competitors, and suppliers with genuine information for understanding the Global Genetic Testing Market.

Get Impressive discount @:

https://www.reportspedia.com/discount_inquiry/discount/68234

Market segment by Type, the product can be split into:

CancerCystic fibrosisSickle cell anemiaDuchenne muscular dystrophyAlzheimer diseaseThalassemiaHuntington diseaseOthers

Market segment by Application, split into:

Newborn screeningDiagnostic testingCarrier testingPreimplantation genetic diagnosisPrenatal diagnosisPredictive and presymptomatic testingPharmacogenomics

The Genetic Testing Market study projects viability analysis, SWOT analysis, and various other information about the leading companies operating in the Global Genetic Testing Market provide a complete efficient account of the viable environment of the industry with the aid of thorough company profiles. However, Genetic Testing research examines the impact of current market success and future growth prospects for the industry.

Inquire Before Buying @:

https://www.reportspedia.com/report/life-sciences/global-genetic-testing-market-report-2020-by-key-players,-types,-applications,-countries,-market-size,-forecast-to-2026-(based-on-2020-covid-19-worldwide-spread)/68234#inquiry_before_buying

In this study, the years considered to estimate the market size of Genetic Testing are as follows:

Table of Contents:

Get Full Table of Content @:

https://www.reportspedia.com/report/life-sciences/global-genetic-testing-market-report-2020-by-key-players,-types,-applications,-countries,-market-size,-forecast-to-2026-(based-on-2020-covid-19-worldwide-spread)/68234#table_of_contents

Excerpt from:
Global Genetic Testing Market Report Reviews Trends, Revenue, Size, Share, Growth opportunities, Competitive Landscape Analysis And Forecast to 2026 -...

Recommendation and review posted by Bethany Smith

Scholar advocates expanding federal legal protections against genetic discrimination.

For two decades, police unsuccessfully searched for a Los Angeles serial killer who murdered several people over a span of three years. The killings remained a mystery until the murderercommonly referred to as the Grim Sleeperstruck again 14 years later.

That time, authorities used a technique called familial DNA searching and found that the serial killer was related to a man who had undergone genetic testing and was already in a police database. This genetic information allowed authorities to narrow the list of suspects, ultimately leading them to a conviction for 12 murders.

Although stories such as that of the Grim Sleeper highlight the benefits that can come from increased access to genetic information, one scholar argues that stricter legal protections are needed to ensure that the information gathered through genetic testing cannot be used improperly by private firms, such as insurers, as a means to discriminate against consumers.

In a recent article, Michael Dohn of Belmont University College of Law argues that the federal law under The Genetic Information Nondiscrimination Act of 2008 (GINA) needs to be expanded to prevent genetic information from being used to determine placement in schools as well as eligibility for life, disability, and long-term care insurance.

Currently, GINA prohibits employers from using genetic test results to determine compensation or make hiring decisions, Dohn explains. The Act also bars health insurance companies from using genetic information to determine eligibility, premiums, and contributions.

Although GINA provides these legal protections from genetic discrimination in the workplace and health insurance markets, it does nothing to prevent life, disability, and long-term care insurance companies from using genetic test results to determine eligibility. Dohn points to one illustrative case in which an insurance company legally denied a young woman life insurance simply because she admitted to testing positive for a gene that indicated she had an increased risk of developing breast cancer.

Genetic test results can also be used to determine school placement. Dohn highlights a recently settled California case in which a school district transferred a student to another school after his parents submitted school forms indicating the student was a carrier for cystic fibrosis. The school determined the student should be transferred to reduce the risk that other students with cystic fibrosis would get an infection from a carrier of the disease.

If the court in this case had determined that carriers for genetic diseases were not protected under a federal law that prevents discrimination based on disability, the school district might have been able to use the students genetic information to decide where the student could go to school, Dohn worried.

Genetic test results that reveal an individuals biological sex might also be used to discriminate against transgender people, although a recent U.S. Supreme Court decision held that discrimination based on gender identity in cases where a persons gender identity may not match their biological sex is prohibited under federallaw as sex discrimination.

Individuals genetic test results can become available for discriminatory use when consumers submit samples of saliva or cheek swabs to companies that provide direct-to-consumer genetic testingsuch as 23andMe or Ancestry.com. These companies can use the genetic material in the sample to provide customers with information about their ancestry or health, such as increased risk of developing certain diseases, Dohn says. Although he recognizes that genetic information can provide consumers with both medical and entertainment value, Dohn warns that serious concerns still exist about who can access genetic test results.

With rapid advancements in the field of genetics, Dohn suggests that professionals could use the raw data from the genetic test results to uncover a consumers personal health information. Hackers could also access personal health information through cyber-attacks targeting genetic testing companies, he explains.

Some of the direct-to-consumer genetic testing companies also share consumer information with third-party research groups, Dohn says. Although the genetic testing companies remove identifying personal information before sharing, researchers have demonstrated that someone who is given an individuals raw genetic data and basic demographic information for that individual can use this information to identify the individual.

Dohn also points out that consumers may directly provide third parties with access to their genetic information by agreeing to undergo genetic testing or by publicly sharing their test results. When consumers share their genetic information, however, they are often unaware that this information can then be used to deny them services or access to facilities, Dohn argues.

To protect consumers and prevent third parties from discriminating based on genetic information, Dohn says that GINA needs to be expanded to fill the gaps where consumers are left unprotected.

He recognizes that opponents to expanding GINA argue that there are few documented cases of discrimination to date, and that state laws may be able to provide additional protections if there are concerns about discrimination in areas unprotected by federal legislation. But he responds that, as technology advances and scientists better understand how genetic information relates to diseases, individuals will become more vulnerable to discrimination based on the results of genetic tests.

Without an expansion to GINA, states alone cannot protect individuals from discrimination, Dohn says. He argues that state regulations vary in how much protection to give genetic information, creating a need for Congress to impose a uniform standard capable of adapting to advancements in the field of genetics.

The ever-increasing access to information should be accompanied with ever-expanding protections, Dohn concludes.

Continue reading here:
Regulating the Use of Genetic Information - The Regulatory Review

Recommendation and review posted by Bethany Smith

Predictive Genetic Testing and Consumer/Wellness Genomics Market: Snapshot

Genetic testing comprises examination of ones DNA. The term DNA refers to the chemical database that is responsible for conveying the instructions for functions that need to be performed by the body. Genetic testing is capable of revealing changes or mutations in the genes of living beings, which might result in any kind of disease or illness in the body.

Get Exclusive PDF Sample Copy Of This Report:https://www.tmrresearch.com/sample/sample?flag=B&rep_id=1274

Predictive genetic testingrefers to the utilization of genetic testing methods in an asymptomatic individual to make a prediction about risk of contacting particular disease in future. These tests are regarded as representation of emerging class of medical tests, which differ in fundamental ways from the usual diagnostic tests.

The global predictive genetic testing and consumer/wellness genomics marketis likely to gather momentum owing to the benefits offered by predictive genetic testing.

The benefits of predictive genetic testing are

The global predictive genetic testing and consumer/wellness genomics marketis influenced by reducing cost of genetic sequencing and technological advancement in the field of genetics. North America is expected to emerge as a prominent region for the global predictive genetic testing and consumer/wellness genomics market in years to come due to high adoption rates of latest technologies in all fields.

Over centauries human DNA has undergone tremendous alteration due to evolutionary and lifestyle changes. They have led to both, advantages and disadvantages over the years. Some have given the mankind a deserving edge over other creatures while the others have led to disorders and diseases. Predictive genetic testing and consumer/wellness genomics market thrives on the growing demand for understanding the lineage of a certain gene pool to identify disorders that could manifest in the later or early stage of a human life. The surging demand for understanding the family history or studying the nature of certain diseases has given the global market for predictive genetic testing and consumer/wellness genomics market adequate fodder for growth in the past few years.

This new class of medical tests are aimed at reducing the risk of morbidity and mortality amongst consumers. The thorough surveillance and screening of a certain gene pool can allow an individual to avoid conditions that disrupt normal existence through preventive measures. The clinical utility of these tests remains unassessed. Therefore, increasing research and development by pharmaceutical companies to develop new drugs by understanding diseases and disorders is expected to favor market growth.

Unlike conventional diagnostic testing, predictive genetic testing identifies the risk associated with potential conditions. In certain cases it is also capable of stating when the disease may appear and the how severe will it be. Thus, this form of testing is expected to allow consumers to take up wellness measurements well in time to lead a life of normalcy, characterized by good health.

Buy This Report @https://www.tmrresearch.com/checkout?rep_id=1274<ype=S

Global Predictive Genetic Testing and Consumer/Wellness Genomics Market: Overview

Predictive genetic testing are used to identify gene mutations pertaining to the disorders that surface at a considerably later stage in life after birth. These tests are particularly beneficial for people from a family with a history of genetic disorder, although they themselves show no symptoms of the disorder at the time of testing. Genetic testing promises to revolutionize the healthcare sector, providing crucial diagnostic details related to diverse verticals such as heart disease, autism, and cancer. As the healthcare sector touches new peaks, the global predictive genetic testing and consumer/wellness genomics market is projected to expand at a healthy growth rate during the forecast period of 2017 to 2025.

This report on the global market for predictive genetic testing and consumer/wellness genomics analyzes all the important factors that may influence the demand in the near future and forecasts the condition of the market until 2025. It has been created using proven research methodologies such as SWOT analysis and Porters five forces. One of the key aspect of the report is the section on company profiles, wherein several leading players have been estimated for their market share and analyzed for their geographical presence, product portfolio, and recent strategic developments such as mergers, acquisitions, and collaborations.

The global predictive genetic testing and consumer/wellness genomics market, on the basis of test type, can be segmented into predictive testing, consumer genomics, and wellness genetics. The segment of predictive testing can be sub-segmented into genetic susceptibility test, predictive diagnostics, and population screening programs, whereas the segment of wellness genetics can be further divided into nutria genetics, skin and metabolism genetics, and others.

By application, the market can be segmented into breast and ovarian cancer screening, cardiovascular screening, diabetic screening and monitoring, colon cancer screening, Parkinsons or Alzheimers disease, urologic screening or prostate cancer screening, orthopedic and musculoskeletal screening, and other cancer screening. Geographically, the report studies the opportunities available in regions such as Asia Pacific, Europe, North America, and the Middle East and Africa.

Global Predictive Genetic Testing and Consumer/Wellness Genomics Market: Trends and Opportunities

Increasing number of novel partnership models, rapidly decreasing cost of genetic sequencing, and introduction of fragmented point-solutions across the genomics value chain as well as technological advancements in cloud computing and data integration are some of the key factors driving the market. On the other hand, the absence of well-defined regulatory framework, low adoption rate, and ethical concerns regarding the implementation, are expected to hinder the growth rate during the forecast period. Each of these factors have been analyzed in the report and their respective impacts have been anticipated.

Currently, the segment of predictive genetic cardiovascular screening accounts for the maximum demand, and increased investments in the field is expected to maintain it as most lucrative segment. On the other hand, more than 70 companies are currently engaged in nutrigenomics, which is expected to further expand the market.

Global Predictive Genetic Testing and Consumer/Wellness Genomics Market: Regional Outlook

Owing to robust healthcare infrastructure, prevalence of cardiovascular diseases, and high adoptability rate of new technology makes North America the most lucrative region, with most of the demand coming from the country of the U.S. and Canada. Several U.S. companies hold patents, which further extends the outreach of the market in the region of North America.

Companies mentioned in the research report

23andMe, Inc, BGI, Genesis Genetics, Illumina, Inc, Myriad Genetics, Inc, Pathway Genomics, Color Genomics Inc., and ARUP Laboratories are some of the key companies currently operating in global predictive genetic testing and consumer/wellness genomics market. Various forms of strategic partnerships with operating company and smaller vendors with novel ideas helps these leading players maintain their position in the market.

To know more about the table of contents, you can click @https://www.tmrresearch.com/sample/sample?flag=T&rep_id=1274

About TMR Research

TMR Research is a premier provider of customized market research and consulting services to busi-ness entities keen on succeeding in todays supercharged economic climate. Armed with an experi-enced, dedicated, and dynamic team of analysts, we are redefining the way our clients conduct business by providing them with authoritative and trusted research studies in tune with the latest methodologies and market trends.

Follow this link:
PREDICTIVE GENETIC TESTING AND CONSUMER/WELLNESS GENOMICS MARKET TRENDS AND DYNAMIC 2025 - Scientect

Recommendation and review posted by Bethany Smith

Thursday, August 27, 2020

Does payer coverage of genomic testing drive utilization? That is the question The Personalized Medicine Coalition (PMC) asked and answered in its recent report Understanding Genomic Testing Utilization and Coverage in the US (Study). PMCs Study, conducted in collaboration with BlueCross/BlueShield Association, Concert Genetics, and Illumina, sought to uncover patterns between the clinical use of genomic testing and payer coverage. Three clinical areas were studied: noninvasive prenatal testing (NIPT) in prenatal screening, whole exome sequencing (WES) in patients with rare and undiagnosed genetic diseases, and comprehensive genomic profiling (CGP) of tumors in patients with advanced cancer.

Four key findings were highlighted in the Study.1In sum, payer coverage of medically appropriate genomic tests is increasing, but this increase in coverage did not correspond with higher utilization of testing across the United States. As such, medically appropriate genetic testing was inconsistently utilized across the United States. While inconsistent coverage and reimbursement policies are barriers to patient access to testing, the Study concluded that these policies do not entirely explain inconsistent test utilization. Other utilization barriers were identified for further attention.

The Study acknowledged that obtaining payer coverage and reimbursement for genomic testing is one of several challenges to providing patients access to these medically important tests.2However, other challenges were identified that prevent full test access. These included a lack of clarity and consistency of payer coverage policies within and between states and across clinical areas. Identified barriers to test utilization were: socioeconomic determinants of health (such as the distance patients must travel to access genomic medical specialists), cultural and community factors (including known racial and ethnic health disparities across the health care systems), and data security and privacy concerns. Lack of awareness, knowledge and education of personalized medicine among health care providers and patients were also identified as ongoing challenges to full test utilization.

There is no doubt that research and development of personalized medicine diagnostics and therapies have been increasing but room for improvement remains. As noted by the Study:

Over the last 20 years, a steadily growing number of genetic biomarkers that contribute to disease have been discovered. New targeted therapies being developed to improve outcomes for responder patients add to this value proposition. However, utilization rates for medically appropriate NIPT, WES, and CGP genomic testing are inconsistent and variable even when favorable coverage policies exist. The full value of genomic testing cannot be realized unless utilization increases."3

The authors of the Study encourage proponents of personalized medicine to continue to develop and disseminate evidence supporting the clinical and economic benefits of genomic testing. Additional studies that evaluate each identified barrier and its impact on access and utilization will help address and remove barriers to access for every patient that needs it.

-------------------------------------------------------

1Study at page 5.2Study at page 21.3Study at page 22.

2020 Foley & Lardner LLPNational Law Review, Volume X, Number 240

See the original post here:
Payer Coverage Drive Genomic Test Utilization in the US? - The National Law Review

Recommendation and review posted by Bethany Smith

The research report on the global DTC Genetic Testing Market offers an all-encompassing analysis of recent and upcoming states of this industry which also analyzes several growth strategies for market growth. The DTC Genetic Testing report also focuses on the comprehensive study of the industry environment, and industry chain structure extensively. The DTC Genetic Testing report also sheds light on major factors including leading vendors, growth rate, production value, and key regions.

Request for a sample report here @:

https://www.globalmarketers.biz/report/life-sciences/global-dtc-genetic-testing-market-report-2020-by-key-players,-types,-applications,-countries,-market-size,-forecast-to-2026-(based-on-2020-covid-19-worldwide-spread)/153716#request_sample

Top Key Players:

Color GenomicsLaboratory Corporation of AmericaMapMyGenomeGene by Gene23andMeAfrican AncestryHelixWeGeneMyriad GeneticsPathway GenomicsQuest DiagnosticsThermo Fisher

DTC Genetic Testing Market Fragment by Areas, regional examination covers

United States, Canada, Germany, UK, France, Italy, Russia, Switzerland, Sweden, Poland, , China, Japan, South Korea, Australia, India, Taiwan, Thailand, Philippines, Malaysia, Brazil, Argentina, Columbia, Chile, Saudi Arabia, UAE, Egypt, Nigeria, South Africa and Rest of the World.

The DTC Genetic Testing Market report introduces the industrial chain analysis, downstream buyers, and raw material sources along with the correct comprehensions of market dynamics. The DTC Genetic Testing Market report is articulated with a detailed view of the Global DTC Genetic Testing industry including Global production sales, Global revenue, and CAGR. Additionally, it offers potential insights about Porters Five Forces including substitutes, buyers, industry competitors, and suppliers with genuine information for understanding the Global DTC Genetic Testing Market.

Get Impressive discount @:

https://www.globalmarketers.biz/discount_inquiry/discount/153716

Market segment by Type, the product can be split into:

Disease Risk and HealthAncestry or GenealogyKinshipLifestyle

Market segment by Application, split into:

On-line SalesDoctors Office

The DTC Genetic Testing Market study projects viability analysis, SWOT analysis, and various other information about the leading companies operating in the Global DTC Genetic Testing Market provide a complete efficient account of the viable environment of the industry with the aid of thorough company profiles. However, DTC Genetic Testing research examines the impact of current market success and future growth prospects for the industry.

Inquire Before Buying @:

https://www.globalmarketers.biz/report/life-sciences/global-dtc-genetic-testing-market-report-2020-by-key-players,-types,-applications,-countries,-market-size,-forecast-to-2026-(based-on-2020-covid-19-worldwide-spread)/153716#inquiry_before_buying

In this study, the years considered to estimate the market size of DTC Genetic Testing are as follows:

Table of Contents:

Get Full Table of Content @:

https://www.globalmarketers.biz/report/life-sciences/global-dtc-genetic-testing-market-report-2020-by-key-players,-types,-applications,-countries,-market-size,-forecast-to-2026-(based-on-2020-covid-19-worldwide-spread)/153716#table_of_contents

Go here to read the rest:
Global DTC Genetic Testing Market Trends, Key Players, Overview, Competitive Breakdown and Regional Forecast by 2026 - Scientect

Recommendation and review posted by Bethany Smith

SAN CARLOS, Calif., Aug. 27,2020 /PRNewswire/ --Natera, Inc.(NASDAQ: NTRA), a pioneer and global leader in cell-free DNA, today announced a collaborative agreement with Mass General Cancer Center (MGCC) of Massachusetts General Hospital, related to an investigator-initiated multi-center, Phase II randomized clinical trial of Ribociclib (Kisqali), a CDK4/6 inhibitor, for the treatment of ER-positive breast cancer (LEADER), the first circulating tumor DNA (ctDNA)-based study of a CDK4/6 inhibitor in ER-positive early stage breast cancer.

LEADER (part II) will randomize patients who have localized post-menopausal breast cancer with detectable ctDNA after surgery as evidence of minimal residual disease (MRD), and will determine tumor molecular response after Ribociclib in combination with endocrine therapy versus endocrine therapy alone. Natera's Signateratest will be used to determine patient enrollment eligibility based on presence of ctDNA via longitudinal monitoring and to evaluate response based on ctDNA clearance as the primary endpoint.

"With the overwhelming evidence that patients with detectable ctDNA are at high risk for relapse, our goal is to investigate a new treatment strategy for these patients and reduce risk of disease recurrence," said Aditya Bardia, MD, MPH, the study's principal investigator from MGCC, Harvard Medical School. "Since the LEADER trial is in the MRD setting, it is critical to use a highly sensitive assay."

Breast cancer remains the second leading cause of cancer death in women in the United States,1 and the U.S. Food and Drug Administration (FDA) has approved Ribociclib in combination with aromatase inhibitors as a first-line treatment option for advanced/metastatic (stage IV) disease.

"We are proud to partner with Massachusetts General Hospital on this exciting new approach of using Signatera personalized ctDNA analysis for enrollment and evaluation of treatment response to CDK4/6 inhibitors in the MRD setting," said Alexey Aleshin, MD, MBA, Natera's Senior Medical Director for Oncology."We believe this collaboration may pave the way for more trials using ctDNA to study the effectiveness of an investigational drug in early stage breast cancer."

About Signatera

Signatera is a custom-built ctDNA test for treatment monitoring and MRD assessment in patients previously diagnosed with cancer. The test is available for clinical and research use, and it was granted Breakthrough Device Designation by the FDA in 2019. The Signatera test is personalized and tumor-informed, providing each individual with a customized blood test tailored to fit the unique signature of clonal mutations found in that individual's tumor. This maximizes accuracy for detecting the presence or absence of residual disease in a blood sample, even at levels down to a single tumor molecule in a tube of blood. Unlike a standard liquid biopsy, Signatera is not intended to match patients with any particular therapy. Rather, it is intended to detect and quantify how much cancer is left in the body, to detect recurrence earlier and to help optimize treatment decisions. Signatera's test performance has been clinically validated in multiple cancer types including colorectal, non-small cell lung, breast, and bladder cancers.Signatera has been developed and its performance characteristics determined by Natera, the CLIA-certified laboratory performing the test. The test has not been cleared or approved by the US Food and Drug Administration (FDA). CAP accredited, ISO 13485 certified, and CLIA certified.

About Natera

Naterais a global leader in cell-free DNA testing. The mission of the company is to change the management of disease worldwide with a focus on women's health, oncology, and organ health. Natera operates an ISO 13485-certified and CAP-accredited laboratory certified under the Clinical Laboratory Improvement Amendments (CLIA) in San Carlos, Calif. It offers proprietary genetic testing services to oncologists, obstetricians, and transplant physicians, as well as to researchers and biopharmaceutical companies. For more information, visit natera.com. Follow Natera on LinkedIn.

Forward-Looking Statements

All statements other than statements of historical facts contained in this press release are forward-looking statements and are not a representation that Natera's plans, estimates, or expectations will be achieved. These forward-looking statements represent Natera's expectations as of the date of this press release, and Natera disclaims any obligation to update the forward-looking statements. These forward-looking statements are subject to known and unknown risks and uncertainties that may cause actual results to differ materially, including with respect to our efforts to develop and commercialize new product offerings, our ability to successfully increase demand for and grow revenues for our product offerings, whether the results of clinical or other studies will support the use of our product offerings, our expectations of the reliability, accuracy and performance of our screening tests, or of the benefits of our screening tests and product offerings to patients, providers and payers. Additional risks and uncertainties are discussed in greater detail in "Risk Factors" in Natera's recent filings on Forms 10-K and 10-Q and in other filings Natera makes with the SEC from time to time. These documents are available at http://www.natera.com/investorsand http://www.sec.gov.

Contacts

Investor Relations: Mike Brophy, CFO, Natera, Inc., 510-826-2350Media: Paul Greenland, VP of Corporate Marketing, [emailprotected]

References

1. How Common Is Breast Cancer? The American Cancer Society. Updated January 8,2020. Accessed July 14, 2020. https://www.cancer.org/cancer/breast-cancer/about/how-common-is-breast-cancer.html.

SOURCE Natera, Inc.

http://www.natera.com

See the rest here:
Natera Announces Collaboration with Massachusetts General Hospital for a Prospective Randomized Clinical Trial in Early Stage Breast Cancer -...

Recommendation and review posted by Bethany Smith

DALLAS--(BUSINESS WIRE)--Avero Diagnostics, a physician-owned laboratory, is pleased to announce the expansion of its COVID-19 testing portfolio with the addition of the Roche Elecsys Anti-SARS-CoV-2 antibody test. Serological testing supports the Centers for Disease Control and Prevention (CDC) efforts to more accurately understand how many people have been infected with SARS-CoV-2, the virus that causes COVID-19, and how it is spreading. This offering, available now, will complement Averos existing COVID-19 molecular testing program, which Avero launched in May 2020 to support the diagnostic needs of area hospitals, health systems, multi-specialty family practices, urgent care centers, and county health departments.

As the medical and scientific communities work to understand and stop the spread of COVID-19, serological testing serves as a piece of the very complex puzzle, said Trae Mattison, MD, Managing Partner, Avero Diagnostics. By expanding our COVID-19 testing services, we are not only supporting the need for serology testing in our community, we are also contributing to the national effort to understand the spread of the SARS-CoV-2 virus.

A serological test, often called antibody testing, is used to determine whether a person may have had a past infection with the virus that causes COVID-19. This test uses a blood sample to provide qualitative detection of high-affinity antibodies to SARS-CoV-2, to aid in identifying individuals with an adaptive immune response to SARS-CoV-2, indicating recent or prior infection. This assay enriches detection of higher affinity antibodies which are more likely to be specific for SARS-CoV-2. While this assay in principle can detect antibodies of all isotypes (i.e., IgG, IgA, IgM), it preferentially detects IgG antibodies. This test is recommended for individuals 14 days post-symptom onset, or five to seven days following exposure to individuals with confirmed COVID-19.

Avero Diagnostics CLIA-certified and CAP-accredited laboratory is using the Roche immunoassay for the qualitative detection of antibodies against SARS-CoV-2. The test is an electro-chemiluminescence immunoassay with 99.8% specificity. Avero can initially process approximately 800 tests per day, with the potential to scale up capacity based on demand. Avero expects to provide results to ordering providers within 24 to 48 hours.

For more information, visit http://www.averodx.com.

About Avero Diagnostics

Avero Diagnostics is a physician-owned laboratory and an affiliate of Progenity, Inc. (Nasdaq: PROG), dedicated to providing high quality anatomic pathology, molecular pathology, and genetic testing services to physicians and their patients. Avero Diagnostics provides sub-specialized pathology services in the areas of breast, gynecologic, gastrointestinal, molecular, and urologic pathology. The company also offers specialized testing services in genetic carrier testing and noninvasive prenatal screening. Avero is focused on improving healthcare delivery to patients through the research and development of novel diagnostic equipment and assays, offering a faster and more accurate result. Avero Diagnostics vision is to lead the healthcare industry in the delivery of anatomic pathology, molecular pathology and genetic testing. For more information, please visit http://www.averodx.com.

Read the original:
Avero Diagnostics Expands COVID-19 Testing Capabilities with Launch of Serology Testing - Business Wire

Recommendation and review posted by Bethany Smith

News

Genetic sequencing revealed the man in Hong Kong had been infected with two different strains of the coronavirus.

Nothing too surprising. I suspect reinfection is happening a lot more often than we have bothered to find yet. Itll be happening more frequently in areas where theres lots of transmission.That is Associate Professor Ian Mackay, a prominent virologist from the University of Queensland, commenting on a pre-print study, released on 24 August, of the worlds first confirmed case of COVID-19 reinfection.The 33-year-old man first tested positive on 26 March in Hong Kong. He was hospitalised with mild symptoms including cough, sore throat, fever and headache.Then on 15 August 142 days after the first infection the man tested positive again, this time during a routine entry screening to Hong Kong airport after having travelled to Spain via the UK. The man was hospitalised again, but remained asymptomatic.The research team from The University of Hong Kong, led by microbiologist Dr Kelvin Kai-Wang To, used genetic testing to analyse viral samples taken from the patient collected 10 days after his symptoms emerged during the first episode, and one day after he was hospitalised the second time.It shows that some people do not have lifelong immunity, Dr To said. We dont know how many people can get reinfected. There are probably more out there.As a result, he said patients with previous COVID-19 infection should continue to comply with epidemiological control measures, such as social distancing and mask-wearing.

Two additional cases of reinfection, one in the Netherlands and another in Belgium, were confirmed by virologists via genetic testing on Tuesday, according to AAP.The prospect of reinfection has been speculated throughout the pandemic so far, with numerous anecdotal reports. But UHKs pre-print study, accepted for publication in the journal Clinical Infectious Diseases, is the first to confirm reinfection with rigorous testing.The discovery is also in line with recent studies that show antibodies start to wane within around three months.But rather than raise alarm, Associate Professor Mackay says this is a sign of the body functioning effectively.Thats what the body does; it makes its initial response, it develops the immune cells, but it doesnt keep producing antibodies to every single thing or else our blood would be like pea soup it would be sick with antibodies and proteins, he told newsGP.So most of the time youll develop those antibodies, theyll go away, but youre left with the traces of immunity that will fire up again should you ever be challenged by that same virus.Researchers used genetic sequencing to confirm reinfection, showing infections from two viral strains of SARS-CoV-2 that were clearly different.Associate Professor Mackay says while viral mutation is common, it can create confusion and anxiety outside of the scientific community.In this case, the second infection was a slightly different genetic code to the first. It is still the same virus, it all falls under SARS-CoV-2, but theyre just subtly different, he explained.A virus is really a cluster of subtly different variants of that virus, and it is constantly changing. So if I was to be infected with SARS-CoV-2, I would have a lot of different variants as they vie for the position to get the next cell and replicate the fastest to then be transmitted.

VirologistAssociate Professor Ian Mackay suspects reinfection is happening a lot more often than we have bothered to find yet.

With many of the worlds borders closed and travel otherwise significantly restricted, the virologist says such control measures have an impact on a virus evolution similar to that of animal species that are living in isolation.For example, on an island like the Galapagos youll see specific animals that havent evolved the same way in other places because theyve been isolated, while theyve replicated generations of new offspring, Associate Professor Mackay said.Viruses are doing the same thing, and each time they produce new offspring they can be subtly tuned to be more adapted to their environment, which might be that person.They might have changed some of the things that that persons immune response attacks so they can escape from it, or they may have found that one of those particular viruses that came in had the ability to replicate a little faster, so it overtook some of the other viruses.So youve got all this variation going on, and the fittest viruses are the ones that are likely to be coughed or sneezed out at the other end. And then theyll go on and start the whole process in the next patient.As is seen in the study, he says scientists have the ability to track each of these changes through genomic sequencing.We can sequence the entire 30,000 nucleotides the library of its life and see how those changes have occurred from person-to-person first, country-to-country, plane-trip-to-city, whatever it might be when you compare A to B, youll see those differences, Associate Professor Mackay said.Could these mutations, however, have implications for the development of a vaccine?If there is significant change in the sequence being used to create the vaccine, it is possible but unlikely, according to Associate Professor Mackay.Theres no sign that thats been the case here [in Australia], or in any of the work done so far, he said.It seems like all of the vaccines that are underway do mount the right kind of immune response that will still take out all the different variants of this SARS-CoV-2 wherever it might be, whether its a new mutant or whatever.The fact the mans second infection was less severe than the first makes the study a case in point.This is kind of a way of testing that in this particular case youve got two different genetic variants, but it looks like the immunity from the first infection prevented the second infection causing the patient to get ill, Associate Professor Mackay said.So they were, if you like, vaccinated by the first case and disease was prevented in the second infection.Professor Nigel McMillan, Director in Infectious Diseases and Immunology at Menzies Health Institute Queensland at Griffith University, says the findings indicate that countries such as Sweden relying on natural herd immunity are on the wrong path.This will not be effective, he said.Going forward what we need to know is how long T-cell immunity lasts in naturally infected people and, more importantly, how long vaccine responses last as this will determine how often we need to be vaccinated.Associate Professor Mackay agrees. He believes a vaccine is still the way out of the pandemic for countries with high transmission, as well as others like Australia.If we all get vaccinated and we have some immunity develop, then well develop some memory and that means when we get infected a second time, we will hopefully see the same kind of thing that happens here [in the study], he said. Which is to say, we could still be infected out in the wild if we all were to meet up with the virus again after wed been vaccinated, but we wouldnt get severely sick or we wouldnt die.If it was to produce another kind of immunity that prevented moderate or even mild illness, fantastic.But, right now, we just want to prevent that severe disease and death.Log in below to join the conversation.

coronavirus COVID-19 immunity reinfection

Originally posted here:
newsGP - What are the implications of the first case of COVID reinfection? - RACGP

Recommendation and review posted by Bethany Smith

SINGAPORE: There is"no known" caseof COVID-19 reinfection in Singapore to date, andthe Ministry of Health (MOH) is "actively investigating" the possibilityof reinfectionamong those who have recovered from the disease.

Following reports of recoveredCOVID-19 casesin Hong Kong, Belgium and the Netherlands becoming reinfected with the coronavirus, an MOH spokesperson said on Thursday (Aug 27) that the ministrycontinues to review global and local clinical research and evidence on COVID-19 reinfection.

MOH will "monitor the situation closely", said thespokespersonin response to CNA queries.

We have also been actively investigating the possibility of reinfection among persons who have recovered from COVID-19, when they seek subsequent medical care for acute respiratory infectionsymptoms," the spokesperson added.

On Monday, researchers at the University of Hong Kong said a Hong Kong man who recovered from COVID-19 was reinfected four-and-a-half months later.

It was the first documented instance of human reinfection.The 33-year-old man was cleared of COVID-19 and discharged from hospital in April, but tested positive again after returning from Spain via Britain on Aug15.

The patient had appeared to be previously healthy, researchers said in the paper, which was accepted by the international medical journal Clinical Infectious Diseases.

He was found to have contracted a different coronavirus strain from the one he had previously contracted and remained asymptomatic for the second infection.

The finding does not mean taking vaccines will be useless,DrKai-Wang To, one of the leading authors of the paper, told Reuters.

"Immunity induced by vaccination can be different from those induced by natural infection," he said."(We) will need to wait for the results of the vaccine trials to see if how effective vaccines are."

World Health Organization (WHO) epidemiologist Maria Van Kerkhove said on Monday that there was no need to jump to any conclusions, in response to the Hong Kong case.

On Tuesday, a patient in the Netherlands and another in Belgium were confirmedto have been reinfected with the coronavirus, reported Dutch national broadcaster NOS, citing virologists.

NOS cited virologist Marion Koopmans as saying the Dutch patient was an older person with a weakened immune system.

She said that cases where people have been sick with the virus a long time, and it then flares up, are better known.But a true reinfectionrequires genetic testing of the virus in both the first and second infections to see whether the two instances of the virus differ slightly.

Koopmans, an adviser to the Dutch government, said reinfections had been expected.

"That someone would pop up with a reinfection, it doesn't make me nervous," she said. "We have to see whether it happens often."

The Belgian patient had mild symptoms, NOS reportedvirologist Marc Van Ranst as saying. He said the case shows that antibodies the patient developed during the first exposure were not enough to prevent a second infectionwith aslightly different variant of the virus.

An infectious disease specialist in China's expert group for COVID-19 treatment, Wang Guiqiang, also offered several explanations about reinfection, as reported by Reuters.

One explanation was that the virus still existed in the lungs of patients but was not detected in samples taken from upper parts of the respiratory tract, he said. Other possible causes could include thelow sensitivity of tests and weak immunity that could lead to persistent positive results.

Downloadourappor subscribe to our Telegram channel for the latest updates on the coronavirus outbreak:https://cna.asia/telegram

Here is the original post:
No known case of COVID-19 reinfection in Singapore, says MOH - CNA

Recommendation and review posted by Bethany Smith

Are you suffering from low hormone levels?

Specializing in hormone replacement therapy and anti-aging, Elite HRToffers the most up to date treatment options available to optimize your physical and emotional health to the highest level possible, helping you to get your edge back.

Our fully personalized age management and wellness programs, incorporating Physician prescribed hormone replacement therapy (HRT), wellness coaching and program monitoring will help to slow down and even reverse the signs and symptoms of aging so you can look and feel your absolute best at any age. How you look and feel as you age is entirely up to you, you can make the years to come the best years of your life. Take the first step toward a fitter, younger and healthier you. Our team of expert Physicians and wellness consultants are here to guide you every step of the way. Together, well help you to look better, feel younger and stay healthier.

Call us for a free private consultation, your call is completely confidential and no obligation is required, youll be glad you did. Prefer information via email? Submit your questions and concerns using one of our contact forms. One of our Physicians or wellness consultants will respond right away.

Read the rest here:
Hormone Replacement Therapy - Hormone Doctor | Elite HRT

Recommendation and review posted by Bethany Smith

Endocrinology is the study of medicine that relates to the endocrine system, which is the system that controls hormones.Endocrinologists are specially trained physicians who diagnose diseases related to the glands. Because these doctors specialize in these conditions, which can be complex and have hard-to-spot symptoms, an endocrinologist is your best advocate when dealing with hormonal issues.

Most patients begin their journey to the endocrinologist with a trip to their primary care provider or family doctor. This doctor will run a series of tests to see what could be the potential problem the patient is facing. If a problem with the hormones is suspected, the primary care doctor will provide a referral. The endocrinologist's goal is to restore hormonal balance in the body.

The glands in a person's body release hormones. Endocrinologists treat people who suffer from hormonal imbalances, typically from glands in the endocrine systemor certain types of cancers. The overall goal of treatment is to restore the normal balance of hormonesfound in a patient's body.

Most of the work performed by an endocrinologist serves as the basis for ongoing research. Some endocrinologists work solely as research physicians. The goal of the research is to come up with new ways to better treat hormonal imbalances, including the development of new drugs.

The first step to become an endocrinologist is earning a bachelor's degree from an accredited college or university. Toward the end of the bachelor's program, a student will then have to apply for and be accepted to medical school. Once accepted, four more years of schooling will have to be completed. Most endocrinologists will complete a residency that lasts anywhere from three to four years. After schooling has been completed, it is then mandated that a state license be obtained.

Common courses that will have to be completed to become an endocrinologist include:

It usually takes at least 10 years for a person to complete all of the necessary coursework, schooling and training to become an endocrinologist. From the year 2010 through 2020, there is an expected growth rate of 24 percent for this position. Before a person starts the educational path to becoming this type of physician, it is highly recommended that he or she carefully consider whether or not it is the right path.

Read the rest here:
What is Endocrinology? | Hormone Health Network

Recommendation and review posted by Bethany Smith

Hormones are your bodys chemical messengers. Produced in the endocrine glands, these powerful chemicals travel around your bloodstream telling tissues and organs what to do. They help control many of your bodys major processes, including metabolism and reproduction.

When you have a hormonal imbalance, you have too much or too little of a certain hormone. Even tiny changes can have serious effects throughout your whole body.

Think of hormones like a cake recipe. Too much or too little of any one ingredient affects the final product. While some hormone levels fluctuate throughout your lifetime and may just be the result of natural aging, other changes occur when your endocrine glands get the recipe wrong.

Read on to learn more about hormonal imbalances.

Your hormones play an integral role in your overall health. Because of that, theres a broad range of symptoms that could signal a hormonal imbalance. Your symptoms will depend on which hormones or glands arent working properly.

Common hormonal conditions affecting both men and women could cause any of the following symptoms:

In women, the most common hormonal imbalance is polycystic ovary syndrome (PCOS). Your normal hormonal cycle also changes naturally during:

Symptoms of a hormonal imbalance specific to women include:

Testosterone plays an important role in male development. If you arent producing enough testosterone, it can cause a variety of symptoms.

In the adult male, symptoms include:

Puberty is the time when boys and girls start producing sex hormones. Many children with delayed puberty will go on to experience normal puberty, but some have a condition called hypogonadism. Symptoms of hypogonadism include:

In boys:

In girls:

There are many possible causes for a hormonal imbalance. Causes differ depending on which hormones or glands are affected. Common causes of hormonal imbalance include:

Many causes of hormonal imbalance in women are related to reproductive hormones. Common causes include:

Theres no single test available for doctors to diagnose a hormonal imbalance. Begin by making an appointment with your doctor for a physical exam. Be prepared to describe your symptoms and the timeline along which theyve occurred. Bring a list of all medications, vitamins, and supplements youre currently taking.

Your doctor may ask you questions such as:

Depending on your symptoms, your doctor may suggest one or more diagnostic tests. You can also ask your doctor to perform these tests.

Your doctor will send a sample of your blood to a lab for testing. Most hormones can be detected in the blood. A doctor can use a blood test to check your thyroid, estrogen, testosterone, and cortisol levels.

If youre female,your doctor may perform a pap smear to feel for any unusual lumps, cysts, or tumors.

If youre male, your doctor may check your scrotum for any lumps or abnormalities.

An ultrasound machine uses sound waves to look inside your body. Doctors may use an ultrasound to get images of the uterus, ovaries, testicles, thyroid, or pituitary gland.

Sometimes more advanced tests are required. These can include:

If youre experiencing symptoms of menopause, you may be tempted to try a home testing kit. Home testing kits measure follicle-stimulating hormone (FSH) in your urine. FSH levels increase when you enter menopause, but levels also rise and fall during a normal menstrual cycle. A home testing kit can give you an indication of whether menopause has started, but it cant tell you conclusively.

Treatment for a hormonal imbalance will depend on whats causing it. Common treatment options include:

If youre experiencing uncomfortable symptoms of menopause like hot flashes, your doctor may recommend a low dose of estrogen. Be sure to discuss the risks and benefits of hormone replacement therapy with your doctor.

If youre experiencing vaginal dryness or pain during sex, you may want to try applying an estrogen cream, tablet, or ring. This local therapy treatment avoids many of the risks associated with systemic estrogen, or estrogen that travels throughout the bloodstream to the appropriate organ.

If youre trying to get pregnant, hormonal birth control can help regulate menstrual cycles. Types of hormonal birth control include:

It may also help improve acne and reduce extra hair on the face and body.

Androgens are male sex hormones that are present in both women and men. Women with high androgen levels may choose to take medication that blocks the effect of androgens, such as:

Metformin is a type 2 diabetes medication that may help some women with PCOS symptoms. It isnt approved by the U.S. Food and Drug Administration (FDA) to treat PCOS, but it might help lower androgen levels and encourage ovulation.

Testosterone supplements can reduce the symptoms of low testosterone in men. In adolescents with delayed puberty, it stimulates the start of puberty. It comes as an injectable, patch, and gel.

In people with hypothyroidism, the synthetic thyroid hormone levothyroxine (Levothroid, Levoxyl, Synthroid, Unithroid) can bring hormone levels back into balance.

Addyi and Vyleesi are the only medications that are FDA-approved for the treatment of low sexual desire in premenopausal women. Addyi is a pill, and Vyleesi is a self-administered injectable medication.

These drugs may come with some serious side effects, such as severe nausea and changes in blood pressure. Talk to your doctor to see if either one could be right for you.

This is a prescription cream designed specifically for excessive facial hair in women. Applied topically to the skin, it helps slow new hair growth, but doesnt get rid of existing hair.

There are many nutritional supplements on the market that claim to treat menopause and hormone imbalance. However, few of them are backed up by scientific evidence.

Many of these supplements contain plant-derived hormones. These are sometimes called bioidentical hormones because they chemically resemble the bodys natural hormones. There is no evidence to suggest that they work better than regular hormone therapy, though.

Some people find that yoga helps treat symptoms of hormonal imbalance. Yoga is excellent for your strength, flexibility, and balance. It may also help you lose weight, which can help regulate your hormones.

You can also make the following lifestyle changes:

The primary cause of acne is excess oil production, which leads to clogged pores. Acne is most common in areas with many oil glands, including the:

Acne is often associated with pubescent hormonal changes, but theres actually a lifelong relationship between acne and hormones.

The menstrual cycle is one of the most common acne triggers. For many women, acne develops the week before you get your period and then clears up. Dermatologists advise hormonal testing for women who have acne in combination with other symptoms, like irregular periods and excess facial or body hair.

Androgens are male hormones present in both men and women. They contribute to acne by overstimulating the oil glands.

Both girls and boys have high levels of androgens during puberty, which is why acne is so common at that time. Androgen levels typically settle down in the early 20s.

Hormones play an integral role in metabolism and your bodys ability to use energy. Hormone disorders like hypothyroidism and Cushing syndrome can cause you to become overweight or obese.

People with hypothyroidism have low levels of thyroid hormones. This means that their metabolism doesnt work as well as it should. Even when dieting, people with hypothyroidism can still gain weight.

People with Cushing syndrome have high levels of cortisol in their blood. This leads to an increase in appetite and an increased fat storage.

During menopause, many women gain weight because the metabolism slows down. You may find that even though youre eating and exercising like normal, you still gain weight.

The only way to treat weight gain from a hormone disorder is to treat the underlying condition.

During a normal, healthy pregnancy, your body goes through major hormonal changes. This is different than a hormonal imbalance.

Hormonal imbalances like PCOS are among the leading causes of infertility. In women with PCOS, the hormonal imbalance interferes with ovulation. You cant get pregnant if youre not ovulating.

Pregnancy is still possible in women with PCOS. Losing weight can make a big difference in your fertility. There are also prescription medications available that can stimulate ovulation and increase your chances of becoming pregnant.

In vitro fertilization (IVF) is also an option if medication doesnt work. As a last resort, surgery can temporarily restore ovulation.

PCOS can cause problems during pregnancy, for both you and your baby. There are higher rates of:

Babies born to women with untreated hypothyroidism have a higher risk of birth defects. This includes serious intellectual and developmental problems.

Hormonal changes and imbalances can sometimes cause temporary hair loss. In women, this is often related to pregnancy, childbirth, or the onset of menopause. An over- or underproduction of thyroid hormones can also cause hair loss.

Most hair loss, like male pattern baldness, is hereditary and unrelated to hormonal changes.

Hormone imbalances are associated with many chronic, or long-term, health conditions. Without proper treatment, you could be at risk of several serious medical conditions, including:

Hormones are responsible for many of your bodys major processes. When hormones get out of balance, the symptoms can be extremely varied. Hormonal imbalance can cause a variety of serious complications, so its important to seek treatment as soon as possible.

Read more from the original source:
Hormonal Imbalance: Symptoms, Treatment, Tests, and Causes

Recommendation and review posted by Bethany Smith

Transparency Market Research (TMR)has published a new report titled, Testosterone Replacement Therapy Market Global Industry Analysis, Size, Share, Growth, Trends, and Forecast, 20192027.According to the report, the globalTestosterone Replacement Therapy marketwas valued atUS$ 1,613.7 Mnin2018and is projected to expand at a CAGR of4.4%from2019to2027.

Request Brochure for Report https://www.transparencymarketresearch.com/sample/sample.php?flag=B&rep_id=1097

Overview

Request for Analysis of COVID19 Impact on Testosterone Replacement Therapy Market https://www.transparencymarketresearch.com/sample/sample.php?flag=covid19&rep_id=1097

Growing Awareness about Testosterone Replacement Therapy to Drive Market

Buy Testosterone Replacement Therapy Market Report https://www.transparencymarketresearch.com/checkout.php?rep_id=1097&ltype=S

Competitive Landscape

The global Testosterone Replacement Therapy market is fragmented in terms of number of players. Key players in the global market includeAbbVie, Inc., Allergan plc, Bayer AG, Endo Pharmaceuticals, Inc., Eli Lilly and Company, Kyowa Kirin International plc, Mylan N.V., Novartis AG, Pfizer, Inc., Clarus Therapeutics, and Ferring Holding SA, among others

About Us

Transparency Market Research is a global market intelligence company providing global business information reports and services. Our exclusive blend of quantitative forecasting and trends analysis provides forward-looking insight for several decision makers. Our experienced team of analysts, researchers, and consultants use proprietary data sources and various tools and techniques to gather and analyze information.

Our data repository is continuously updated and revised by a team of research experts so that it always reflects latest trends and information. With a broad research and analysis capability, Transparency Market Research employs rigorous primary and secondary research techniques in developing distinctive data sets and research material for business reports.

Contact

Transparency Market Research,

90 State Street, Suite 700,

Albany, NY 12207

Tel: +1-518-618-1030

USA Canada Toll Free: 866-552-3453

Website: https://www.transparencymarketresearch.com/

Read the rest here:
Testosterone Replacement Therapy market to Grow at a Whopping 4.4% from 2019 to 2027 - The Daily Chronicle

Recommendation and review posted by Bethany Smith

It wasnt the first time Sharon Haber found a lump in her neck. Shed had them twice before the last one 10 years prior. Both times, they were benign. Still, she knew she had to get it checked out.

Habers primary care doctor in Encino, California, agreed that the small lump in her neck, under her left ear, most likely was nothing. But he ordered a CT scan, just in case. When the scan came back, the doctor still believed the lump was benign. Out of an abundance of caution, he sent her to a head and neck specialist for a second look. The specialist biopsied the lump, which he also expected to be benign.

A couple of days later, when I got the call that I have cancer, that was probably the scariest moment of my life, Haber says. The 69-year-old retired marriage and family counselor now has been cancer free for more than six years.

Haber had three lesions on her parotid gland one of the three major salivary glands and the most common one on which tumors can form. The majority of growths that develop on this gland are benign. In fact, salivary gland cancers are extremely rare. In the U.S., they make up less than 1% of all cancers diagnosed each year.

And thats cases spread throughout the U.S., so, of course, a lot of people havent even heard of it, says Dr. Maie St. John, chair of head and neck surgery at Ronald Reagan UCLA Medical Center in Los Angeles.

There are dozens of types of salivary gland cancers nearly as many as there are types of cells that compose the salivary glands. Most of the time, these can be treated with single modality surgery, depending on the anatomic location, and patients can have a very good outcome. Doctors usually recommend radiation after surgery to ensure no cancer cells are left behind and to lower the risk of recurrence. But for some people surgery is not possible or doesnt completely remove the cancer. In some cases, the cancer returns. Clinical trials underway are exploring the roles that chemotherapy and targeted drugs can play in treating this rare disease.

WHAT IS SALIVARY GLAND CANCER?

Cancerous tumors can arise in the three major salivary glands or any of the thousands of minor glands that line the mouth and extend into the nose and pharynx, the cavity that connects the nose and mouth to the esophagus.

The three pairs of major salivary glands are the parotid, sublingual and submandibular glands. The parotid, the largest of these glands, occupies the side of the face between the ear and the back molars. It extends to the height of the upper and lower jaws. The sublingual gland sits in the floor of the mouth under the tongue. The submandibular is located under the lower jaw.

Doctors grade cancers from low to high based on how abnormal the cells look under a microscope. Low-grade cancer cells look the most like normal cells and tend to be slower growing and less aggressive. These cancers are usually easier to treat and have better long-term survival rates. High-grade cancers, on the other hand, look very different from normal cells and grow and spread faster than lower grade cases.

Salivary gland cancers are as diverse as they are rare.

There are many differences in salivary gland cancers, says Dr. Ashok Shaha, the Jatin P. Shah Chair in Head and Neck Surgery and Oncology at Memorial Sloan Kettering Cancer Center in New York. The greatest variation in human cancers is probably in salivary gland tumors. And the more we look into the basic differentiation of these cells, the more different names for them keep coming up.

Mucoepidermoid carcinomas are the most common salivary gland cancers. They most often arise in the parotid gland but can appear in the other major glands, as well. These are usually low-grade cancers, but intermediate- and high-grade cases do occur.

Adenoid cystic carcinomas are slow growing, low- grade cancers, but they spread along nerves. Even if you go in and remove everything you can see and feel, there still could be a few cells that run along the nerve. Those cells spread by using the nerve like a little highway, and this would predispose patients to recurrence, St. John says. This type of cancer can recur many years after the initial treatment.

Adenocarcinoma is a general term to describe cancers of the gland cells. Salivary adenocarcinoma describes numerous subtypes of both low- and high-grade cancers, some of them quite rare.

WHAT ARE THE SYMPTOMS?

A common symptom of salivary gland cancers, particularly those that arise in the parotid gland, is a lump in the side of the face or neck like Haber had.

Something I hear from my male patients is I was shaving, and I felt this lump, says Dr. Theodoros Teknos, president and scientific director of the UH Seidman Cancer Center and a head and neck oncologist at University Hospitals Cleveland Medical Center.

A painless lump could be an early sign of cancer. As the disease progresses, depending on the location of the tumor, it can cause earaches, trouble swallowing or difficulty opening the mouth.

Numbness and pain can develop in the face, as well. Its not a sudden paralysis such as Bells palsy. The gradual numbness may start with one lip, then include another, and eventually spread to other parts of the mouth or face.

Mark Fetterman, a 59-year-old construction foreman in Olmstead Falls, Ohio, started having pain and numbness on one side of his face in 2016. A neurologist told him he had trigeminal neuropathy. This disorder affects the trigeminal nerve, which controls facial sensation and movement. Imaging tests didnt find any cause for the condition. The doctor prescribed medications, but over the next two years, the pain and numbness became worse. In 2018, Fetterman found a lump in the roof of his mouth. A biopsy found that it was salivary duct carcinoma, a rare, high-grade adenocarcinoma.

The [physician] said that the cancer was all along the trigeminal nerve going up to his brain, but not in his brain, and that it might have been this all along, says Fettermans wife, Lori.

SURGERY & RADIATION

For almost everyone with salivary gland cancer, surgery is the first treatment. Depending on the tumors location and size, the surgeon may be able to remove the cancer completely. But, because tumors may be near the eyes, in the mouth or nose, near the brain, or in the face on crucial nerves or blood vessels, the surgery comes with risks of adverse effects. It can cause temporary or permanent loss of movement in the face. But surgeons make every effort to avoid this.

We do parotid surgery with a nerve monitor so you can monitor and preserve the nerve, St. John says. We do not sacrifice the facial nerve unless the cancer is just wrapped around it and it has to be taken in order to clear the cancer. Otherwise, we dissect around it.

Habers tumor was on her facial nerve. She knew going into it that surgery came with the risk of partial paralysis. All I could think about was my grandkids, she recalls.

I didnt want to look scary to them. But after an 11-hour surgery performed by St. John, Haber says, she not only got all the cancer, and took out all the lymph nodes around it, but she did not hit that nerve. She saved my face and my life.

Doctors often recommend following surgery with radiation therapy to address residual microscopic cancer cells. If a tumor is inoperable, radiation sometimes in combination with chemotherapy may be the main treatment.

SYSTEMIC TREATMENTS

Chemotherapy isnt a first-line treatment for salivary gland cancers. Salivary gland cancers are considered relatively chemo-resistant tumors, says Shaha. If a patient has a poor prognosis or if they have [had a recurrence], then we would add chemotherapy.

Investigators are exploring through clinical trials whether chemotherapy, which is not typically used for salivary gland treatment, might improve outcomes when added to surgery and radiation.

In general, systemic treatments medications that travel through the bloodstream as opposed to procedures that target the tumor directly for salivary gland cancers are considered experimental. Patients with recurring or metastatic cancers may receive these treatments in clinical trials.

In a salivary gland cancer thats metastasized, we typically (gene) sequence the tumor, look at the muta- tions, and try to provide targeted therapies for the specific tumor, Teknos says.

In salivary duct carcinomas, for example, the HER2 gene is often overactive. The genes hyperactivity can help the tumor grow and thrive. In HER2-positive tumors, the blockbuster breast cancer drug Herceptin (trastuzumab) blocks that genes activity and may slow or stop tumor growth.

Fetterman is still taking Herceptin. He receives an IV transfusion of the drug every three weeks. On the last CT scan, the cancer was unchanged. It hadnt grown or shrunk. So I will continue to take it, and they will just keep monitoring it, he says.

People with this type of cancer also may be candidates for androgen receptor inhibitors, drugs commonly used to treat prostate cancer. Androgen receptors, which by some estimates, are present in up to 98% of salivary duct carcinomas, support the growth of tumors that thrive on androgen hormones. These drugs can block the receptors and deprive the tumor of the hormone. In a clinical trial, this treatment led to higher response rates than chemotherapy in metastatic or recurrent disease.

In other clinical trials, investigators are exploring other genetic targets in salivary gland tumors that might align with existing targeted drugs. In the phase 2 MyPathway trial (NCT02091141), researchers matched patients with targeted drugs based on the tumors genetic profile. Because salivary cancers are so rare, the trial included only 19 people. Twelve of them (63%) responded to the personalized treatments they received.

Numerous other trials are in progress. In cases of metastatic or recurring salivary gland cancers, clinical trials may be the only remaining treatment options.

FINDING CARE

Because salivary gland cancers are so rare, doctors recommend that patients find a hospital with a track record. You dont need to go to another state, Shaha says, but you need to go to a center where head and neck surgery is very common and there are recognized experts in salivary gland tumors.

But its not just the surgeon that matters. Salivary gland cancers can affect facial appearance and function and psychological well-being. Treatment can require a team. Reconstructive surgeons help maintain or restore facial appearance. Physical and speech therapists work with patients to maintain function. Radiologists and medical oncologists collaborate on nonsurgical aspects of care. Mental health professionals provide support for coping with life changes brought about by the cancer.

It is what we call a multidisciplinary team, Shaha says. You need a good surgeon. You need a good radiologist. You need a medical oncologist. You need a radiation therapist or radiation oncologist, and a good pathologist. If you have that team, thats a real place where you want to be treated.

Continued here:
Salivary Gland Cancer: As Rare As It Is Diverse - Curetoday.com

Recommendation and review posted by Bethany Smith

Biomedical engineers at Duke University have shown that the efficacy of a two-pronged type 2 diabetes treatment increases when the drugs are linked by a heat-sensitive tether rather than simply concurrently administered. The combination molecule is formed by an elastin-like polypeptide (ELP) linker that forms a gel-like depot when injected under the skin, which slowly dissolves and releases the active drug over time.

This novel approach features the commonly prescribed type 2 diabetes drug glucagon-like peptide-1 (GLP-1) and the compelling drug candidate fibroblast growth factor 21 (FGF21) that together create tight glycemic control and potent weight-reduction in diabetic mice. Coupled with the slow-release function of the ELP, the effects last longer than one week with a single injection.

Because GLP-1, a short peptide, and FGF21, a large folded protein, are such different compounds, these findings suggest that this approach to combination drug design could be applied to disease therapies beyond diabetes.

The results appear online on August 26 in the journalScience Advances.

"In the burgeoning field of multi-functioning single-molecule diabetes drug design, researchers primarily unite drugs that are similar in size, structure and function," said Caslin Gilroy, a postdoctoral scholar at the University of California, Berkeley, who led the project while completing her PhD in biomedical engineering at Duke. "Being able to combine such structurally distinct drugs into a single molecule while maintaining the bioactivity and stability of each is a big technological achievement."

Type 2 diabetes is a progressive disease where body tissues become resistant to the effects of insulin, which regulates the movement of sugar from the bloodstream into cells. When this carefully tuned system breaks down, blood sugar levels remain toxically elevated and a host of serious complications can follow. While many treatment options exist, a single drug is rarely able to treat an advanced case. Conventional medications lose their potency over time and frequently cause weight gain, which itself can promote insulin resistance and exacerbate the disease.

A growing class of drugs is based on GLP-1, a naturally occurring peptide released from the intestines after a meal. GLP-1 therapy enhances the release of insulin from the pancreas while promoting weight loss. However, the high doses of GLP-1 that are sometimes necessary to maintain healthy blood sugar levels have been shown to cause gastrointestinal distress. Researchers are exploring combination therapies that strategically pair GLP-1 with additional drugs to maximize glucose control, minimize side effects and augment weight loss.

While most drug combinations incorporate small peptides from the same family as GLP-1, Gilroy and Ashutosh Chilkoti, the Alan L. Kaganov Distinguished Professor of Biomedical Engineering at Duke, chose to work with FGF21. A metabolic hormone, FGF21 regulates insulin sensitivity, energy expenditure and fat metabolism within body tissues.

"FGF21 functions through a different mechanism than GLP-1, and we hypothesized that the two drugs would complement each other nicely," said Gilroy. "GLP-1 increases insulin secretion by the pancreas, while FGF21 enhances the body's response to the insulin. GLP-1 reduces food intake, while FGF21 helps burn more calories."

But rather than simply injecting diabetic mice with both drugs at the same time, the researchers decided to link GLP-1 and FGF21 together into a single molecule. This approach to combination therapy has several advantages. A single molecule is more predictable in how it will disperse through the body, act on its target tissues and eventually be cleared. A single drug is also beneficial for the prescribing physician and patient, as it reduces the medication burden and simplifies the treatment regimen. And the FDA approval process for a single drug is more straightforward than for a drug mixture.

GLP-1 and FGF21, however, are both peptide-based drugs, heavily reliant on shape and surface features to function. Tethering the two without interfering with either is easier said than done.

To form one drug out of two, the researchers turned to the ELP--a specialty of the Chilkoti research group. ELPs are chains of repetitive peptide sequences that are highly disordered in nature. This disorder provides flexibility, enabling drugs fused at each end of the ELP the room to do their respective jobs. The modularity of ELPs also make them highly tunable, allowing for the design of the best delivery system possible.

Peptide-based drugs suffer from two notable disadvantages; they have a short half-life, due to rapid clearance from the body, and they must be administered by needle. An ELP-based delivery platform, however, addresses both of these issues.

"Linking the drugs to an ELP allows us to design a compound that is liquid at room temperature but forms a gel-like depot upon injection," said Gilroy. "The depot dissolves over the course of at least a week, slowly and regularly releasing drug to the system over time."

Chilkoti already has two Phase II clinical trials underway using ELPs as slow-release delivery systems. One trial aims to treat pulmonary arterial hypertension, while the second involves a potential therapy for COVID-19.

In the study, after verifying that GLP-1 and FGF21 retain their respective functions and potencies when linked together by an ELP, Gilroy and Chilkoti tested their multi-functioning, slow-release molecule in a mouse model of diabetes.

The results show that levels of drug circulating in the system remained steady while blood sugar levels were brought down to a healthy level and maintained for up to 10 days following a single dosing. Mice treated with the GLP-1/FGF21 combination drug were better able to recover from a glucose challenge compared to either drug alone, and were the only test group to lose weight during the trial.

The drug combination also worked better when GLP-1 and FGF21 were tethered together rather than being delivered as a mixture of individual drugs. The researchers think that linking them guarantees that GLP-1 and FGF21 are always acting in concert at the same point in time, allowing their mechanisms of action to synergize and work together.

"We had speculated that we may see synergy when we combined GLP-1 and FGF-21 because they have different modes of action," said Chilkoti. "That was really just a hope at the outset of this project, and we were more than pleasantly surprised when Caslin showed that combining these drugs into a single molecule clearly showed a synergistic therapeutic effect compared to a mixture of the two drugs. The data is so compelling that we believe it's ready for a company to pursue this strategy commercially. Duke's Office of Licensing and Ventures is currently looking to license it."

Reference: Gilroy CA, Capozzi ME, Varanko AK, et al. Sustained release of a GLP-1 and FGF21 dual agonist from an injectable depot protects mice from obesity and hyperglycemia. Sci Adv. 2020;6(35):eaaz9890. doi:10.1126/sciadv.aaz9890

This article has been republished from the following materials. Note: material may have been edited for length and content. For further information, please contact the cited source.

Read this article:
Type 2 Diabetes Drugs Work Better Tethered Together - Technology Networks

Recommendation and review posted by Bethany Smith

There was a very popular meal replacement that was all the rage in 2013 Soylent, were talking about Soylent whose inventor lived on it for one month straight and said he felt superb. Better skin, better energy levels and above all, more productivity!

The product made headlines for the implication that you can live on nothingbut Soylent, although nowadays the company is careful to put a disclaimer on all of their products:Soylent is not intended to replace every meal, but it can replace any meal.

Thats the tactic that we take toward meal replacements: that they can be a useful, although not perpetual, replacement for a meal.

Now, weve tried dozens and dozens of these supplements to land on our list of best meal replacements, and while there are plenty of crummy options that are low in protein and low in nutrients some of them are, well, really good.

Our top pick Huel, for example, has 28 vitamins and minerals, a good balance of macronutrients, its not too low in calories, and it even provides Omega-3 fatty acids.

So why cant I just live on this shake alone?

Editors note: The content on BarBend is meant to be informative in nature, but it shouldnt take the place of advice and/or supervision from a medical professional. The opinions and articles on this site are not intended for use as diagnosis, prevention, and/or treatment of health problems. Speak with your physician if you have any concerns.

I have seen a study or two on satiety and hunger. They were comparing people eating food and people drinking a smoothie, says New York-based dietitian Natalie Rizzo, MS, RD. They found people who have to chew the food feel fuller after chewing, even if its the same nutrients and calories.

This study was published in Hormone and Metabolic Research in 2007, and it did indeed conclude that hunger hormones like ghrelin were affected differently in solid versus liquid food.(1) It concluded that shakes,

led to differential appetitive responses and should not be viewed as dietary equivalents in older adults.

But, well, its never that hard to find studies with opposing conclusions.Here are three (2)(3)(4) that said meal replacements can safely and effectively produce significant weight loss and may help to manage blood sugar.

This is not medical advice, mind you talk to a physician before starting a new supplement regimen, especially if you have diabetes. The point is, well, research is conflicting with the appetite stuff. What if you dont struggle with your appetite? Or you take a fiber supplement, like psyllium husk, that can boost satiety? Or what if youre not trying to lose weight?

[Related: Micronutrients vs Macronutrients What Should You Focus On?]

What if your meal replacement is really good?

Not something like Slimfast, which has just 2 grams of protein per serving. Lets say its something like Huel, who we promise did not sponsor this article. Its got a good balance of macros and calories 500 per adjustable serving with 37 grams of protein, 47 grams of carbs and 16 grams of fat Omega-3s, and about 30 percent of the recommended daily intake of 28 vitamins and minerals, including uncommon ones like chromium, choline, chloride.

Youll never make an actual meal with so much of every micronutrient! Why shouldnt I just take this all day, every day?

Ithink that there are some things youre going to miss out on, says Rizzo.There arethings you dont see on the food label that are important, like antioxidants and phytochemicals.Those are plant compounds that have been shown to be really beneficial to heart health and disease risk, things like that.

Wait a minute. Arent macronutrients (protein/carbs/fat) and micronutrients (vitamins/minerals) the only things the government says you need to consume?

Essentially, every single plant-based food has things like antioxidants and phytochemicals and phytonutrients, Rizzo explains.There are thousands of them.The ones we know a lot about are flavonoids, which are usually in the darker colored foods resveratrol is an example thats found in reddish colored foods like grapes and berries that may improve heart health.

Other examples that are just found in broccoliinclude

There are tons of other phytonutrients, and a really big benefit many can confer is their antioxidant effect: they may help to combat inflammation.

Inflammation comes in two different forms, says Rizzo. Theres acute, which is short term and something your body will naturally repair itself from, like the effect of a workout or a bruise. But then theres long term inflammation, which is associated with obesity and chronic disease.If you have inflammation built up in your body for a long period of time, you have a higher risk of developing chronic diseases, and research has found that people who eat more foods with antioxidants and phytochemicals have a lesser chance of getting these sorts of diseases.

Importantly, antioxidants and phytochemicals are not on any food labels, theyre very hard to measure, and the FDA has not set a recommended daily intake for them.

Youll live without these things youve probably met people who live without any vegetables at all but evidence strongly suggests youll live better with them.

[Related: The Best Foods and Supplements for Fighting Inflammation]

Besides phytonutrients, there are other important components to our food that dont have recommended daily intakes, like digestive enzymes.Proteases, lipases, amylases, these are found in whole foods and help you to better absorb the nutrients you do eat they help you make the most of your calories.

Add to that prebiotic fiber and probiotic bacteria. They may improve the health of the trillions of bacteria that live in your digestive tract, and those bacteria may exert an effect on not only your nutrient absorption, but your immunity, inflammation, and physical performance.

[Related: Why Probiotics Are Extra Important for Athletes]

So you kind of just have to eat food.

Meal replacement shakes can have their place but,

At least eat a lot of cruciferous vegetables every day. They have links to just about every health benefit under the sun.

Ideally, youll get all your nutrients from whole foods but hey, sometimes you get busy. Or lazy. We get it, thats why we have meal replacements several times a week but always with some fruits or veggies on the side and with lots of whole foods over the rest of the day.

1.Tieken, SM et al. Effects of Solid versus Liquid Meal-replacement Products of Similar Energy Content on Hunger, Satiety, and Appetite-regulating Hormones in Older Adults. Horm Metab Res. 2007 May; 39(5): 389394.2.Heymsfield, SB et al. Weight management using a meal replacement strategy: meta and pooling analysis from six studies. Int J Obes Relat Metab Disord . 2003 May;27(5):537-49.3.Boonyavarakul, A et al. Effects of meal replacement therapy on metabolic outcomes in Thai patients with type 2 diabetes: A randomized controlled trial. Nutr Health . 2018 Dec;24(4):261-268.4.Kempf, K et al. Individualized Meal Replacement Therapy Improves Clinically Relevant Long-Term Glycemic Control in Poorly Controlled Type 2 Diabetes Patients. Nutrients . 2018 Aug 4;10(8):1022.5.Auborn, K et al. Indole-3-carbinol is a negative regulator of estrogen. J Nutr . 2003 Jul;133(7 Suppl):2470S-2475S.6.Melrose, J et al. The Glucosinolates: A Sulphur Glucoside Family of Mustard Anti-Tumour and Antimicrobial Phytochemicals of Potential Therapeutic Application. Biomedicines. 2019 Sep; 7(3): 62.7.Wu, X et al. Are isothiocyanates potential anti-cancer drugs? Acta Pharmacol Sin. 2009 May; 30(5): 501512.

Original post:
Could You Just Live On Meal Replacement Shakes? - BarBend

Recommendation and review posted by Bethany Smith

The thyroid is an essential endocrine gland that is located at the base of the neck and wraps around the front of the trachea. Its home to a variety of hormones that regulate functions throughout the body. A healthy thyroid gland ensures good metabolic, heart, bone, and muscle health.

The gland is also closely connected with the brain, helping it maintain internal homeostasis. The thyroid significantly influences processes like metabolism, heart rate, emotional responses, and body temperature.

Thyroid disorders can lead to an array of symptoms resulting from dysfunctions in the above processes.

Researchers have revealed some connections between the bodys endocannabinoid system (ECS) and thyroid/brain communication. The ECS might play a role in balancing hormones. If this theory is true, this would mean cannabis products such as CBD oil might be able to help with various types of thyroid disorders.

In todays article, we focus on using CBD oil for thyroid health on top of highlighting the best brands and products in 2020.

Royal CBD is a California-based brand established by a group of friends and cannabis advocates. The company offers premium CBD products in different cannabinoid profiles and concentrations to choose from. Royal CBD collection includes full-spectrum CBD oil, softgel capsules, THC-free gummies, and broad-spectrum topicals.

If youre looking for a high-quality product to support your thyroid health, this is one of the best brands on the market. These oils are available in four potency options, including 250 mg, 500 mg, 1000 mg, and 2500 mg of CBD per bottle. This is a great potency range for both beginners and experienced users alike. The strongest option provides 83.3 mg of CBD per milliliter.

Royal CBD uses organic hemp from Colorado to produce its CBD oils. The plants are gently extracted under low temperatures with pressurized CO2 to ensure the highest purity and consistent purity throughout every batch of products. The company sends samples of their CBD extracts to an independent laboratory for meticulous content analysis.

Similar to Royal CBD, Gold Bee was founded in California, which is no wonder given the size of the cannabis market there and its domination throughout the country. Gold Bee offers some of the best-tasting CBD oils out there; the guys at Gold Bee infuse their hemp extract with a natural honey flavor, which masks the earthiness of full-spectrum CBD.

These oils are great if youre just getting started with CBD or your daily dosage doesnt exceed 40 mg daily. Another great thing about this company is the fact that the other ingredients in its CBD oil, such as the carrier oil, are also sourced organically.

Gold Bee also has softgel capsules, gummies, and honey sticks in its product lineup.

CBDPure is also a good choice if you benefit from lower doses of CBD. This company sells two types of products: CBD oil and capsules. Both products are sourced from Colorado-grown hemp and gently extracted using supercritical CO2. These are full-spectrum extracts, so youre getting all beneficial phytonutrients from hemp on top of CBD, including trace cannabinoids, terpenes, flavonoids, and essential oils.

The CBDPure CBD oil is available in four concentrations: 100 mg, 300 mg, 600 mg, and 1000 mg. The 1000 mg bottle is the latest addition to the brands collection. CBDPure is one of the most transparent brands in the industry. Not only does the company cover all details about its activity, but it also provides third-party lab reports for each batch of products to prove their potency and purity.

CBDPure offers a 90-day satisfaction guarantee program. If you decide the companys products are not for you, you can send your order back for a full refund.

Hemp Bombs is one of the best companies if youre looking for high-quality CBD oils made from isolates. These products are mostly designed for people who are interested only in the health benefits of CBD for thyroid health. Hemp Bombs CBD oils have no odor and flavor, which makes them more versatile than full-spectrum products. The company also sells broad-spectrum extracts, where all the cannabinoids except for THC have been preserved to provide the user with the entourage effect.

Hemp Bombs CBD oils are available in a wide range of concentrations, from 125 mg to a massive 4000 mg of CBD per bottle. You can also choose between 4 delicious flavors, such as Acai Berry, Orange Creamsicle, Peppermint, and Watermelon.

The last brand in our ranking of the best CBD oils for thyroid health support, CBDistillery is one of the pioneer companies that helped establish the American CBD market as we know it today. The company was founded in 2016 as a daughter brand of Balanced Health Botanicals.

CBDistillery offers two types of CBD oil on top of other formats: full-spectrum and broad-spectrum CBD. The broad-spectrum version is labeled as pure oil; similar to Hemp Bombs, CBDistillery has removed the THC from the full-spectrum extract for those who are apprehensive about taking any THC into their bodies.

If youre looking for a wide range of potency options, youre going to have a great time browsing through CBDistillerys CBD oil. Whether youre a beginner or experienced consumer, the company has got you covered from 250 mg to 5000 mg of CBD per bottle. Although the high-potency oils have a higher price tag on the bottle, they turn out more affordable when you calculate the cost per mg of CBD oil.

CBDistillery offers some of the most affordable products in the industry, so if you dont mind the fact their hemp isnt organic, you can trust them as your next supplier especially if youre on a low budget.

Although the research on CBD and thyroid health is limited, current findings suggest that CBD may be beneficial for dealing with thyroid disorders.

According to a 2015 study published in BioMed Research, CB1 and CB2 cannabinoid receptors interfere with molecular pathways and influence the formation of thyroid tumors. Therefore, these receptors could be considered as potential blockers of tumor spread.

We still dont know how exactly CBDs affinity to cannabinoid receptors may affect conditions like Hashimotos Disease or Graves Disease, the presence of these receptors and their influence on thyroid health and function points to CBD as a possible therapeutic agent.

Other research also suggests that CBD and other cannabinoids may come in handy for managing symptoms associated with thyroid disorders, such as anxiety, depression, dry skin, inflammation, and pain.

In a study from the Journal of Experimental Medicine, the administration of CBD and its modified equivalents inhibited chronic inflammatory and neuropathic pain in rodents.

Scientists suggest that CBD taken orally and sublingually provides better effects for the symptoms triggered inside our bodies especially when it comes to stress and depression while topical products work better for localized problems.

The thyroid is prone to suffer from deficiencies in nutrients such as zinc, iodine, and selenium, as well as specific environmental factors, which can cause underperformance.

Also, the immune system can be aggressive towards the thyroid gland, leading to autoimmune thyroid disorders, such as Graves Disease and Hashimotos Disease.

Problems with the thyroid gland may include:

When theres too much or too little of the thyroid hormone, the results may wreak havoc to your well-being over time.

Thyroid disorders are particularly difficult because its challenging to detect and diagnose a specific disorder. Thyroid conditions can cause several problems related to physical functions.

However, doctors use special tests to check for thyroid imbalances. These tests include biopsies and imaging scans, such as iodine or ultrasound screenings. Blood tests that analyze levels of T3, T4, and thyroid-stimulating hormone (TSH) can also determine thyroid imbalances.

The THS measures the amount of thyroxine (T4) that the thyroid should produce.

Below we discuss the two major thyroid disorders: Graves Disease and Hashimotos Disease.

Graves disease received its name after Dr. Robert j. Graves, who first diagnosed a patient with this condition in 1835.

Graves disease is a type of autoimmune thyroid disorder that leads to hyperthyroidism, where the thyroid gland produces too much thyroid hormones. Graves disease is usually the main trigger of hyperthyroidism.

If you suffer from this thyroid disorder, you may experience irritability or nervousness, trembling hands, trouble sleeping, fast and irregular heartbeat, goiter, muscle weakness and tiredness, and weight loss.

Hashimotos thyroiditis is known by another name chronic lymphocytic thyroiditis. This disease is the root of hypothyroid symptoms. Most patients are women after their 40s, although the disease can affect any person regardless of their age.

This autoimmune thyroid condition, which was first diagnosed by Japanese physician Hakaru Hashimoto in 1912, signals the immune system to attack and compromise thyroid function, slowing down its hormone production.

At first, the symptoms are mild and nearly unrecognizable. These symptoms include fatigue, weight gain, hair loss, muscle aches, stiffness, dry skin, intolerance to cold temperatures, stiffness, tenderness, and irregular menstrual cycles (in women).

Doctors usually prescribe Levothyroxine to treat hypothyroidism.its a thyroid hormone used along with radioactive iodine and surgery to treat thyroid cancer. Levothyroxine is used to replace thyroid hormones usually released by the thyroid gland.

Without these hormones, the body cannot perform as usual, which may cause slow speech, lack of energy, muscle, and joint pain, irritation, depression, problems with vision, and slow growth.

A correct treatment with levothyroxine should reverse these symptoms and eventually solve problems with an underactive thyroid.

Most people who have thyroid dysfunction such as Hashimotos disease or Graves disease need to find an underlying autoimmune issue and tackle it. Just taking prescription meds for your disease will simply mask the symptoms.

The easiest thing you can do is embrace natural thyroid treatment and add it to your medication. This begins with adding to and cutting out the diet in the following ways.

Add these products to your diet:

On top of that, you should take care of sufficient protein intake to improve low thyroid function. Proteins may come from organic meat as well as from nuts, nut butter, quinoa, or eggs.

Last but not least, remember to eat more healthy fats. Lack of fats can deteriorate hormonal imbalance, including thyroid hormones. You should add products like ghee, avocado, olive oil, flax seeds, fish, nuts, nut butter, as well as organic diary-like yogurt and cottage cheese. Coconut milk is a good option to consider, too.

Cut out the following products from your diet:

The endocrine system consists of a series of glands in the body that release and secrete hormones for different purposes.

These hormones influence many different physiological processes, including metabolism, fertility, growth, movement, respiration, and sensory perception.

A study conducted by the Polish Society of Endocrinology in 2018 points to potential interrelations between the endocannabinoid system (ECS) and the performance of the endocrine system.

The ECS, the major communication and regulatory network, is responsible to maintain balance between biological processes to help the body maintain overall well-being. This includes controlling thyroid function.

To get a better understanding of how CBD may support thyroid health, its paramount to understand how the ECS functions.

The therapeutic effects of CBD and other cannabinoids are manifested through their interaction with the bodys ECS and its two types of receptors CB1 and CB2.

Scientists have discovered functional CB1 receptors on the thyroid of animal models. These CB1 receptors modulate the release of two thyroid hormones T3 and T4.

Each of these hormones plays a vital role in regulating energy levels, body temperature, body weight, as well as the growth of skin, hair, and nails.

Cannabinoid receptors also occur within the hypothalamic paraventricular nucleus (PVN), which is an area of the brain that communicates with the pituitary gland and signals it to release different types of stimulating hormones to organs like the thyroid, gonads, and adrenal glands.

CBD indirectly regulates these receptors and acts against cannabinoid agonists, which are substances that bind to a receptor to produce their effects.

CBD also has over 65 molecular targets in the body. One of them is the 5-HT1A receptor, which is responsible for serotonin balance. Serotonin is a neurotransmitter that contributes to feelings of relaxation, happiness, and well-being.

The above interactions hold the explanations of the potential healing mechanisms of cannabinoids on the endocrine system.

American Thyroid Association (ATA) reports that people with thyroid disorders choose complementary and alternative medicine for the management of the side effects coming from medication and conventional treatments, such as fatigue, dry mouth, weight gain, and mental fog.

Forming lifestyle habits that help you manage stress, bolster immunity, and prevent inflammation may help improve thyroid health. For example, the Anxiety and Depression Association of America (ADAA) recommends physical activities like exercise to help with sleep problems, which translates to stress reduction. The ATA, on the other hand, suggests yoga, massage, and Pilates reduce stress.

Improving overall immunity should help you fight environmental toxins. Maintaining a healthy diet is the key to avoiding infection. Proper hygiene habits and cooking meats thoroughly also helps build up immunity.

People with thyroid disorders often add anti-inflammatory foods like berries, fatty fish, turmeric, olive oil, or avocados to their diet. Many of the causes of thyroid disease are associated with prolonged inflammation and auto aggression

Using CBD oil may complement the lifestyle and nutrition adjustments, as it has been shown to reduce stress, anxiety, and inflammation, as suggested in a 2019 research paper.

For example, a 2017 study published in Frontiers in Immunology showed that phytocannabinoids strengthen the immune functions of the body. Data from 2018 shows that CBD demonstrates anti-inflammatory properties.

The aforementioned studies indicate that CBD is one of the many cannabinoids found in cannabis that can improve thyroid health and help with thyroid disorders. Therefore, when searching for CBD oil, opt for products that contain the full spectrum of cannabinoids.

Full-spectrum CBD means that the product has been made using the entire hemp plant. As such, it contains all phytonutrients from hemp, including CBD, trace cannabinoids (0.3% THC), terpenes, flavonoids, essential oils, and amino acids. These compounds create synergistic effects that amplify the benefits of each cannabinoid and the therapeutic value of the product.

This concept is better known as the entourage effect.

Those who dont want to take any THC for different reasons may opt for a broad-spectrum product, which contains all of the above except for THC, which has been removed after initial extraction.

However, no matter the type of CBD you choose, wed like to stress the importance of research and careful consideration in selecting the best CBD oil to help with thyroid health.

Follow these steps to save time and money on CBD oil:

If youre looking for a recommended CBD dosage for specific thyroid disorders or any other diseases, you may end up feeling disappointed.

As Peter Grinspoon, MD, says in his article written in Harvard Health in August 2019, experts dont know the most effective therapeutic dose of CBD for any ailment.

Without high-quality human trials, its impossible to determine effective doses. Moreover, Grinspoon says its actually difficult to know what the consumers are getting.

Its generally best to start at low doses, preferably 1-6 mg of CBD for every 10 pounds of your body weight. Grinspoons advice for those shopping for CBD products is to talk with a knowledgeable doctor who will be able to point you in the right direction when it comes to dosing CBD oil as well as to avoid negative interactions with other medications you might be taking.

In a 2017 study, researchers concluded that chronic CBD use in large doses of up to 1500 mg a day had been repeatedly demonstrated to be well tolerated by humans.

CBD is available in many various forms when it comes to managing symptoms commonly linked to thyroid disorders, such as anxiety, depression, pain, inflammation, and dry skin.

The route of administration a person chooses for taking CBD depends on their CBD goals and lifestyle.

CBD oil, capsules, and edibles such as gummies, are a convenient and easy way to take CBD oil, especially for first-time users.

These products are easy to incorporate into a routine, and you can keep the dosage consistent. Depending on your individual metabolism, the effects can last between 4 and 12 hours, so most of the time, youll need 1-2 doses during the day.

CBD oil drops are more efficient than capsules and edibles because they take less time to act and more CBD enters the bloodstream upon ingestion. This effect is caused by sublingual absorption; when you take CBD oil under the tongue, it absorbs through a complex network of blood vessels in your mouth, avoiding the first-pass effect in the liver.

The sublingual application brings results within 1530 minutes after its use, and the effects can last for 46 hours.

Peak blood levels of most substances administered sublingually are noticed within 1015 minutes, which is faster than those same compounds taken orally.

For localized problems, such as inflammatory pain, dryness, and other skin problems, topicals like CBD creams, gels, and patches may be applied to an affected area on the skin to relieve the discomfort. When shopping for topicals, make sure to look for keywords on the product labels that tell if the product uses encapsulation, micellization, or nanotechnology of CBD. These terms indicate that the product can pass through the dermal layers rather than just remaining on the skins surface.

Vaping CBD is the most bioavailable method for some people, delivering up to 56% of the inhaled content to a persons bloodstream. However, vaping raises concerns about potential health problems caused by additives that are infused into CBD oil to make it vapable.

The wide range of health benefits provided by CBD due to its interaction with the endocannabinoid system makes it a viable option for individuals seeking alternative options for treating symptoms of various conditions, including thyroid issues.

A properly assessed dose of thyroid hormone is critical in treating underactive or overactive thyroid. From there, individuals should also take care of their nutrition and introduce healthy changes to their lifestyles. CBD oil may also help regulate certain symptoms and assist the body in regulating its internal processes. However, using CBD for thyroid disorders still calls for more research.

If you think CBD oil could help you manage the symptoms associated with Hashimotos disease or Graves disease, we advise you to consult with a doctor who will be knowledgeable about cannabis treatments. Using professional help will make it easier to determine your optimal CBD dosage and avoid interactions with thyroid medication if youre already taking one.

Follow our recommendations for the best CBD oils for thyroid health, or do your own research according to our guide. Good luck!

Go here to read the rest:
CBD Oil for Thyroid: Is Hemp a Good Treatment for Hypothyroidism? - Weed News

Recommendation and review posted by Bethany Smith