Post COVID-19 Impact on Cancer Stem Cell Market

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Pre COVID-19 Analysis on Cancer Stem Cell Market

According to a study by the World Health Organization (WHO), cancer is the cause for every one death out of six occurrences. Growing cases of cancers such as breast cancer, lung cancer and others due to poor diet patterns, air pollution, sexually transmitted infections, alcohol consumption. Other types of cancer are liver cancer, pancreas cancer, brain cancer, bladder cancer, colon, and blood cancer. The most common cures for cancer are chemotherapy, radiation, and surgeries. These procedures have an adverse effect on the human body. High doses of radiation and chemotherapy destroy the blood-forming stem cells. Stem cells are the soft tissues of the bone that grow inside the bone marrow. Stem cell transplants restore the blood-forming stem cells. These stem cells grow into platelets, RBCs, and WBCs that are required by the body to fight illness and provide oxygen. Usually, these transplants are done within the family to find the closest match.

According to a study,Cancer Stem Cells Marketby Research Dive, the global market will surpass $1,722.7 million by 2026. Rising number of cancer patients, coupled with the latest advancements in cancer stem cells will upsurge the global market by the year 2026.

Regional Investment Opportunities:

North America cancer stem cell market is generated revenue of $365.64 million by end of 2018 and is anticipated to rise at 10% CAGR during the analyzed period. Asia-Pacific market registered a growth rate of 11.2% during the forecast period. This market will surpass $367.68 million by 2026, growing from $157.26 million in 2018. China, India, and Japan are the key contributors to the growth of regional market.

Check out How Stem-cell based cancer segment is will generate revenue of $896.9 Mn by the year of 2026. Click here to know more in details @ https://www.researchdive.com/purchase-enquiry/32

Stem Cells for Cancer

Cancer stem cells or CSCs are a subpopulation of cells that has the driving force of carcinogenesis. Characteristics of cancer stem cells are proliferation, and differentiation capabilities and distinctive self-renewal. These characteristics play a vital role in many stages of cancer such as cancer initiation, drug resistance, progression, maintenance, and metastasis or relapse. CSCs have traits that are linked with normal stem cells and are found within hematological cancers or tumors.

Check out How Cancer stem cells market for breast cancer is projected to hold a dominant share, owing to the genetic influences & alcohol use @ https://www.researchdive.com/download-sample/32

Stem Cell-based therapy

According to the World Health Organization (WHO), the most common cause of deaths in women diagnosed with cancer is breast cancer.Global cancer stem cells marketis projected to reach up to $896.9 million by the end of 2026 as the stem cell-based cancer therapy and targeted cancerous stem cell therapy are advancing in the medical field. Cell-based therapy is split into allogenic Stem Cell therapy and autologous Stem Cell therapy. Allogenic Hematopoietic Stem Cell Transplantation is more beneficial than the autologous Hematopoietic Stem Cell Transplantation for Breast cancer based on different aspects such as cancer-free graft & immune-mediated Graft vs Tumor effect mediated by the donors immune cell.

Successful engraftment rates together with lesser transplant-related mortality and the presence of Graft vs Tumor effect made allogeneic Hematopoietic Stem Cell Transplantation with Reduced Intensity conditioning is the better choice option for the treatment of multiple solid tumors. Due to aforesaid aspects, it is anticipated that allogenic cell therapy will be the rising point for the cancer stem cell market. The global market for stem cell-based cancer therapy is estimated to grow at 9.3% CAGR in 2026 from $440.3 million in 2018.

Advancements in Cancer Stem Cell Transplantation

The prime reason for such huge growth is majorly owed to the rising developments in stem cell therapy of the Asia-Pacific and Europe region. Physicians in Canada are endorsing and promotion of stem cell interventions, which are ethical, legal, and regulatory. U.S. and Canada are leading the cancer stem cell market in the North America region. The North America market is expected to grow over the forecast period and is further projected to generate revenue of $783.8 million by 2026 from its market value of $365.6 million in 2018. While the Asia-Pacific Cancer Stem Cells Market is anticipated to rise to $367.7 Million till 2026 and the Europe Cancer Stem Cells Market is anticipated to generate revenue of $419.5 Million till 2026. Amongst these regions, the Asia-Pacific region is anticipated to be the fastest-growing region for cancer stem cells market. Governing bodies of India, Japan, and other countries are promoting Stem cell transplant by constructing new infrastructure and enlisting new strategies for the launch of centers of stem cells.

The major players in the global cancer stem cell market are introducing several strategies to reinforce their presence in the market

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Segmentation Growth Definition of Cancer Stem Cells Market:

Breast cancer market will surpass $295.0 million in the year 2026, and is anticipated to rise at 10.4% CAGR during the estimate period. The cancer stem cells market for bladder is anticipated to increase at 11.2% CAGR, and will surpass $275.8 million by 2026, rising from $117.9 million in 2018. Global market for stem cell based cancer therapy was $440.3 million by end of 2018 and is anticipated to grow at 9.3% CAGR. This is majorly due to the rising advancements in stem cell therapy of Asia-Pacific and Europe region.

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World Health Organization (WHO) says Cancer is the cause for every one death out of six occurrences which makes Cancer Stem Cells Market to create...

Recommendation and review posted by Bethany Smith

A Nottinghamshire girl needs to find a bone marrow donor within weeks as she battles leukaemia for the second time.

Amy Bartlett, 14, of West Bridgford, was described as a playful, happy and energetic girl before her blood cancer diagnosis.

Having spent part of her childhood in New Zealand, she was a water baby representing her school in water polo and loved to be in the pool and sea, taking part in the little nippers surf life-saving programme.

More recently, she enjoyed being a member of West Bridgfords Colts football team.

In 2018, when she was 12, Amy began to complain of feelings of aches in her wrists and ribs and developed a small rash across her tummy and back.

Tests at Nottingham Childrens Hospital later confirmed she had leukaemia - devastating and heartbreaking news for Amy and her family.

Amy showed strength from the get-go, reassuring her parents that she could fight the blood cancer.

"Mummy, it is ok its better I get it, than another smaller child. I am stronger and so have a better chance to beat it," were her first words after the news was broken to her.

Her leukaemia was categorised as high risk, meaning despite her young age, she had to receive the most intensive rounds of chemotherapy administered to children diagnosed with the disease, causing her hair to fall out within just a few days of treatment starting.

Having not had the smoothest ride through her treatment, suffering liver problems, developing steroid induced diabetes and several allergies to medications she was given, Amy soon needed a wheelchair to get in and out of hospital.

Turning the 12-year-olds life upside down, Amy could not go back to school, but tried desperately hard to keep up with her school work.

Counting down the days until the planned end of her therapy on July 4, the entire family were holding onto the light at the end of the tunnel, when the devastating news of a relapse shattered their dreams.

Her mum Marie said: How do you tell your daughter, whose tiny body has been through so much already, that the cancer she has fought so hard to overcome has returned?

"It ripped my heart out to tell her and hold her whilst trying to convince her that she had done it once and she could do it again.

The relapse has meant that Amy has restarted her intensive chemotherapy. The plan is to then proceed to a bone marrow/stem cell transplant, if a suitable donor match can be found.

Amys family say: We need to find a match for Amy ideally within the next two to three weeks, so time is of the essence.

Her brother, Marcus, has been tested but unfortunately he is not a match.

Amys story comes at a time when new donors are needed urgently amidst falling numbers of people signing up to registers, as planned large scale donor recruitment and awareness sessions cannot be run due to Covid-19, but individuals can still request to join the register independently.

Dr Jesky, Amys Consultant at Nottingham University Hospitals, said: For children or adults, like Amy, whose leukaemia has sadly returned, undergoing a stem cell transplant offers the highest chance of a cure.

"Often these donors are volunteers as many patients do not have a suitable family match. Young men are particularly encouraged to register as they are the most frequent chosen donors.

"For the donor the process of donating is simple but for the patient this donation could give them a second chance at life.

NUH is encouraging people to consider signing up to one of the bone marrow registers to increase the chances of finding a potential match for Amy and others who are in similar circumstances. By doing so, you could be the match that saves a life.

There are four main donor registries.

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You only need to register to one as the information from all registers is collated when looking for a match.

1 . The DKMS Registry (age restriction is 18 to 55 years): https://www.dkms.org.uk/en/register-now

2. The Anthony Nolan Registry (age restriction is 16 to 30 years): https://www.anthonynolan.org/8-ways-you-could-save-life/donate-your-stem-cells

3 . The Welsh Bone Marrow Registry (age restriction is 17 to 31 years): https://www.welsh-blood.org.uk/giving-blood/bone-marrow-donor-registry/

4 . The NHS British Bone Marrow Registry (eligibility determined when you attend to give a blood donation): https://www.bbmr.co.uk/joining-the-register/

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Teenager needs a donor within weeks as she battles leukaemia for second time - Nottinghamshire Live

Recommendation and review posted by Bethany Smith

Michael Schumacher is still surviving as he continues to battle complications from the near-fatal head injury he sustained while skiing in 2013. It was reported that the F1 legend is set to undergo another round of stem cell procedure that will help regenerate his nervous system.

Facts about the reported new operation on Schumi

With this surgery, his family and doctors are hoping that he will be able to recover functions in parts of his body. This is because it is aimed at his sensory system that was affected by his injuries.

The Daily Mail reported that currently, Michael Schumacher is being treated and cared for by French cardiologist Dr. Philippe Menasche, a medical expert specializing in stem cell research. It was revealed that a series of surgeries are needed for this treatment, so this is just one of the racing champs operations for his recovery.

In an article that appeared in an Italian publication Le Dauphine, it was reported that Dr. Menasche will do seminal heart surgery on Schumi in his next surgery schedule. It was added that this will take place soon, but the exact date was not revealed.

It is also believed that this will be the second time that the said doctor is operating on Michael Schumacher. The first procedure was said to have been done in September 2019, and Schumi was in the hospital for about three days. At any rate, in this operation, his damaged cells will be replaced with healthy ones that will be taken from his bone marrow.

An experimental stem-cell surgery?

Michael Schumacher has not recovered from his accident that happened more than six years ago. He is currently being treated in his own home in Switzerland, but his exact condition is still a mystery since his family continues to keep everything related to his health a secret.

Dr. Nicola Acciari, a leading neurosurgeon, previously claimed that Michael Schumacher has osteoporosis and suffering from muscle atrophy since he is unable to move for years. The goal is to regenerate Michaels nervous system, The Sun quoted him as saying in connection to the stem cell therapy.

However, Jean-Michel Dcugis, a French journalist, shared to British daily national newspaper, The Times, that the procedure is experimental at this point since Dr. Menasche is actually a cardiologist.

"Our sources say that Michael Schumacher is receiving stem cell perfusions that produce a systemic anti-inflammatory effect, The Sun quoted Dcugis as saying. "It's quite mysterious as Menasch works only on the heart. He is carrying out experiments with secretome that is made by a laboratory from new stem cells and injected into veins, until now only on animals.

Read more:
Michael Schumacher is reportedly getting another stem-cell surgery; Journalist alleged it will be an experimental procedure - EconoTimes

Recommendation and review posted by Bethany Smith

Latest Research Report: Hematology Instruments and Reagents industry

This has brought along several changes in This report also covers the impact of COVID-19 on the global market.

Global Hematology Instruments and Reagents Market documents a detailed study of different aspects of the Global Market. It shows the steady growth in market in spite of the fluctuations and changing market trends. The report is based on certain important parameters.

Hematology instruments are machines that analyze blood. Used in medical labs, hematology instruments can do blood counts, detect proteins or enzymes, and help to diagnose illnesses or genetic defects.Hematology is the branch of medicine which deals with the study, diagnosis, and treatment of blood-related disorders. It diagnoses issues related to white blood cells, red blood cells, platelets, bone marrow, and lymph nodes. Hematology also deals with the liquid portion of blood known as plasma. Some blood-associated diseases are anemia, leukemia, myelofibrosis, blood transfusion, malignant lymphomas, and bone marrow stem cell transplantation.

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Hematology Instruments and Reagents Market competition by top manufacturers as follow: , Sysmex, Danaher, Nihon Kohden, Siemens, Abbott Laboratories, Boule Diagnostics, HORIBA, Diatron, Drew Scientific, EKF Diagnostics, Mindray, Roche

The risingtechnology in Hematology Instruments and Reagentsmarketis also depicted in thisresearchreport. Factors that are boosting the growth of the market, and giving a positive push to thrive in the global market is explained in detail. It includes a meticulous analysis of market trends, market shares and revenue growth patterns and the volume and value of the market. It is also based on a meticulously structured methodology. These methods help to analyze markets on the basis of thorough research and analysis.

The Type Coverage in the Market are: Hematology InstrumentsHematology Reagents

Market Segment by Applications, covers:Stand-Alone HospitalsCommercial OrganizationsClinical Testing LabsResearch Institutes

The research report summarizes companies from different industries. This Hematology Instruments and Reagents Market report has been combined with a variety of market segments such as applications, end users and sales. Focus on existing market analysis and future innovation to provide better insight into your business. This study includes sophisticated technology for the market and diverse perspectives of various industry professionals.

Hematology Instruments and Reagents is the arena of accounting worried with the summary, analysis and reporting of financial dealings pertaining to a business. This includes the training of financial statements available for public ingesting. The service involves brief, studying, checking and reporting of the financial contacts to tax collection activities and objects. It also involves checking and making financial declarations, scheming accounting systems, emerging finances and accounting advisory.

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Market segment by Regions/Countries, this report coversNorth AmericaEuropeChinaRest of Asia PacificCentral & South AmericaMiddle East & Africa

Report Highlights: Detailed overview of parent market Changing market dynamics in the industry In-depth market segmentation Historical, current and projected market size in terms of volume and value Recent industry trends and developments Competitive landscape Strategies of key players and products offered Potential and niche segments, geographical regions exhibiting promising growth A neutral perspective on market performance Must-have information for market players to sustain and enhance their market footprint

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Global Impact of Covid-19 on Hematology Instruments and Reagents Market to Witness Promising Growth Opportunities During 20202026 with Top Leading...

Recommendation and review posted by Bethany Smith

Even though he had Covid-19, Sila Jio Boonklomjit, a five-year-old boy in Thailand, with covid-19 managed to save his sisters life. With the stem cells he donated for her bone marrow transplant.

Doctors only discovered Jio contracted the coronavirus the day before Jintanakan Jean Boonklomjit, his sisters urgent transplant.

Despite the challenges, which included quarantine restrictions placed on Jio on the eve of the transplant procedure. However the treatment was carried out successfully.

And it was done so without Jio passing the coronavirus to Jean.

While the experimental procedure first began in April, the bone marrow was only successfully transplanted on June23 at Ramathibodi Hospital.

Jeans case was believed to be the first successful stem cell transplant from a donor with active Covid-19, according to reports.

She was reported to be in a severe condition as she wasborn with thalassemia a genetic blood disorder that limits the bloods ability to carry oxygen.

There were also difficulties finding a suitable donor for Jean, which left Jio as their best hope, said Suradej Hongeng of the hospitals pediatrics department.

It was a long and uncertain road to this happy outcome, according to the doctor.

Jio and Jean were confirmed to be a genetic match in 2018. The hospital prepared for the transplantation procedure thereafter.

But with any medical procedures, there were certain complications and hurdles involved.

According to Suradej, the siblings young age were part of the difficulties faced during the procedure. Jeans chemotherapy procedure also caused her immune system to be compromised. That delayed the bone marrow transplant until this year.

Still, things turned out well in the end, and the five-year-old boy was applauded for saving his big sisters life.

Its as if my daughter is reborn and gets a new life, said the childrens father, Suchai Boonklomjit.

Jio has since recovered from Covid-19, which was believed to be transmitted from his mother, according to doctors in Thailand.

Thailands health department has reported on Monday that the Kingdom has gone 35 consecutive days without a local Covid-19 Coronavirus case. However health officials have confirmed 7 imported cases with Thai returnees.

The 7 imported covid-19 coronavirus cases brings the total number of infections in Thailand to 3,169 with 58 deaths since January. All the new cases were Thai nationals in quarantine. They recently returning from India and the US to Thailand.

There have been no local transmissions for 35 days Thailands health department said Monday.

Continued here:
Five Year-old Boy with Covid-19 Saves Sisters Life in Thailand - Chiang Rai Times

Recommendation and review posted by Bethany Smith

Summary

A review of 423 patients treated at MSK finds that most people with cancer dont fare any worse if they get COVID-19 than other people who are hospitalized for that infection.

In the early days of the COVID-19 pandemic, many doctors worried that people undergoing treatment for cancer would do particularly poorly if they became infected with the virus that causes the disease. Thats because treatments for cancer, especially chemotherapy, can lower a persons immune defenses and put them at higher risk for all kinds of infections.

But according to a new study from Memorial Sloan Kettering published June 24 in Nature Medicine, most people in active cancer treatment dont fare any worse if they get COVID-19 than other people who are hospitalized with the infection. Further research is needed to look at the effects of certain drugs mainly immunotherapies called checkpoint inhibitors, which did seem to make COVID-19 worse. But the researchers say their findings suggest that no one should delay cancer treatment because of concerns about the virus.

If youre an oncologist and youre trying to figure out whether to give patients chemotherapy, or if youre a patient who needs treatment, these findings should be very reassuring, says infectious disease specialist Ying Taur, one of the studys two senior authors.

Infectious disease expert Ying Taur has cared for many MSK patients who were hospitalized with COVID-19.

The study looked at 423 MSK patients diagnosed with COVID-19 between March 10 and April 7, 2020. Overall, 40% were hospitalized for COVID-19, and 20% developed severe respiratory illness. About 9% had to be placed on a mechanical ventilator, and 12% died. The investigators found that patients taking immunotherapy drugs called immune checkpoint inhibitors were more likely to develop severe disease and require hospitalization. But other cancer treatments, including chemotherapy and surgery, did not contribute to worse outcomes.

The big message now is clear: People should stay vigilant but not stop or postpone checkpoint immunotherapy or any other cancer treatment.

Factors that did make COVID-19 worse were the same as those seen in studies of people who didnt have cancer. We found that being older, as well as preexisting conditions like heart disease and diabetes, are all drivers of severe COVID-19 illness, says MSK Chief Medical Epidemiologist Mini Kamboj, the studys other senior author. This wasnt surprisingbecause these connections are well established.

Although the study wasnt large enough to make determinations about every treatment and every cancer type, patterns did emerge. Dr. Taur says there was initially great concern about people receiving high doses of chemotherapy for leukemia, especially those who had recently undergone bone marrow or stem cell transplants. Thats because transplants require a persons entire immune system to be wiped out with chemotherapy before they receive new blood cells, leaving them susceptible to all kinds of infections.

Surprisingly, though, Dr. Taur cared for recent transplant recipients who were infected with COVID-19 but didnt have any symptoms. If you think about it more, it makes sense, he says. Most of the complications seen in people with COVID-19 seem to be caused by the bodys immune response to the virus.

On the other hand, immunotherapy drugs called checkpoint inhibitors work by freeing up the immune system to attack cancer. Patients receiving these agents may develop a more robust reaction to the virus that causes COVID-19. This may explain why this study observed higher rates of complications in people with COVID-19 infection who were treated with checkpoint inhibitors.

Even with immune checkpoint inhibitors, though, these findings should not affect whether patients get treated. Everyone who needs these drugs should still receive them, Dr. Kamboj says. Its just important for doctors to be extra vigilant about testing and monitoring for the virus and for people with cancer to take extra precautions to avoid infection.

A study published in May 2020 by MSK immunotherapy expert Matthew Hellmann focused exclusively on people with lung cancer who got COVID-19. The researchers didnt find the same risks from immune checkpoint drugs as this Nature Medicine study. More research in this area is needed.

Dr. Kamboj notes that one aspect of this research that sets it apart from other studies is that it included at least 30 days of follow-up after a COVID-19 diagnosis. Also, it reported severe respiratory illness as a main outcome rather than death.

Having that follow-up time is something that a lot of other studies have not included because everyone is in a rush to get their data out. In addition, reporting death rates can overestimate infection-related mortality, especially in the early phase of an epidemic, Dr. Kamboj says. Also, the clinical spectrum and course of this disease is still not fully understood, especially in people with cancer. We wanted to give patients enough time to recover and make sure they didnt need to be readmitted to the hospital.

Even with immune checkpoint inhibitors, though, these findings should not affect whether patients get treated. Everyone who needs these drugs should still receive them.

She adds that another strength of the study is that patient outcomes were not affected by constraints caused by a lack of space or supplies even though MSK is in the heart of the COVID-19 epicenter in New York City, where other hospitals faced overcrowding and other issues. This gave researchers a true picture of how cancer patients fare with COVID-19. We saw a surge during the peak of the epidemic in New York, but everyone got the care they needed, Dr. Kamboj explains. We had enough ventilators for everyone who needed them. We never had to make decisions about who to admit to intensive care because of a lack of critical equipment.

Drs. Taur and Kamboj agree that this is just one of many studies that will need to be done on the connections between cancer and COVID-19. We still need to find out more. We need to look at the connections between COVID-19 and particular types of cancer as well as outcomes related to specific chemotherapy drugs, Dr. Taur concludes. But the big message now is clear: People should stay vigilant but not stop or postpone checkpoint immunotherapy or any other cancer treatment.

See more here:
Should You Delay Cancer Treatment Because of COVID-19? Study Says Most Treatments Dont Worsen Coronavirus Infection - On Cancer - Memorial Sloan...

Recommendation and review posted by Bethany Smith

NantKwest (NASDAQ:NK) has been one of my best investments over the past year and looks to be ready to move higher following another positive data for cancer and development of a COVID-19 vaccine. Recently, the company's CEO, Dr. Patrick Soon-Shiong "PSS", has been on some news segments discussing some of their fresh cancer readouts and the company's potential to develop a premier COVID-19 vaccine. It looks as if their activated NK cell platform is able to be implemented in multiple disciplines of medicine and could be a vital component in future therapeutics. With the share price rising roughly 1000% since my first buy, I have to make some decisions about how I intend to manage my NK position in the coming days, weeks, months, and years. One wrong move and I could miss the chance to bank some profits or possibly sell too early and miss out on future growth.

First, I will take a look at the recent pipeline updates and data. Second, I will discuss why I am so bullish after the recent offering. Finally, I intend to discuss my course of action that will alleviate both of my concerns.

Out of all of NantKwest's clinical-stage engineered natural killer cell programs, I have been waiting to see some data from their first-in-class PD-L1 t-haNK candidate. The company's PD-L1 t-haNK is created using a haNK cell that has PD-L1 CAR, which will provide an innovative method for targeting PD-L1 tumors. NantKwest recently revealed some positive data for in-vivo models of 15 solid tumors in treatment-refractory cancer types and demonstrated activity in the hypoxic environment.

This is significant because healthy donor NK cells are typically impaired in hypoxic environments, so NantKwest's proprietary off-the-shelf NK cells have an advantage over our own NK cells and potentially other NK therapies. Essentially, NantKwest's NK cells are able to work in a tumor environment that typically disables or nullifies our own NK cells' ability to attack the tumor. In addition, the PD-L1 t-haNK cells were able to show some efficacy in infamously treatment-refractory cancers such as triple-negative breast cancer, lung, and urogenital cancer. PSS believes that their highly targeted NK cell therapies have the potential to take on these highly resistant tumors that have "stem-like" cells, which can be impervious to chemotherapy and checkpoint therapies. In fact, the company reported their first patient with advanced metastatic pancreatic cancer treated with PD-L1 t-haNK has revealed a durable complete response.

Not only am I impressed with the company's ability to create one of these Checkpoint CAR-NK-like cells, but the fact the therapy was able to produce a durable complete response in an advanced metastatic pancreatic cancer patient has turned me into a perma-bull. It looks as if PSS has essentially fused the immunotherapy and cell therapy to create a cutting-edge cancer therapeutic. Once again, PSS and NantKwest have revealed a candidate that could define the next generation of oncology therapeutics.

NantKwest and ImmunityBio are working in collaboration on vaccines and therapeutics to fight COVID-19. ImmunityBio will be working on the development of a vaccine and natural killer cell activation, with their immunomodulators. NantKwest will be focusing on their off-the-shelf, cell-based therapeutics to develop therapeutics for COVID-19. It appears that the goal is to develop a broad array of products to prevent and treat various stages of infection or tissue damage.

So far, ImmunityBio and NantKwest have developed "immunomodulator regimens" for COVID-19 for mild, moderate, severe, and critically ill state (Figure 1). In the early-moderate stage of the disease, the two companies are planning on a clinical trial of ImmunityBio's Il-15 'superagonist' N-803. In addition, they are planning another trial using NantKwest's haNK cell, or haNK in combination with convalescent plasma. In the severely ill, the company is looking to employ bone marrow-derived allogeneic mesenchymal stem cells "BM-Allo-MSC" to diminish the "cytokine storm". These cells can be grown in ImmunityBio's automated GMP-in-a-Box in roughly 7-9 days, which could allow providers to create these therapeutics in-house and essentially on-demand. NantKwest has filed an IND and anticipates beginning trials in the near future.

Figure 1: NantWorks COVID-19 Programs (Source: NantKwest)

In terms of a vaccine, ImmunityBio has a second-generation Ad5 platform that will produce a vector that is immunologically "quiet" and could allow patients who were previously vaccinated with an Ad5 vaccine. In addition, ImmunityBio's vaccine goes after both the spike "S" protein and the nucleocapsid "N" protein in order to induce antigen-specific T-cell immunity. This is significant because it is the only known COVID-19 vaccine that is targeting both, which could allow an extended immunity to the virus compared to vaccines which are only targeting the spike proteins. What is more, this Ad5 platform has demonstrated humoral and cell-mediated immunity for several other deadly viruses such as H1N1, HIV, Chikungunya, and Zika. Therefore, we should expect ImmunityBio's vaccine to show some efficacy against COVID-19 and perhaps be the premier vaccine.

Once COVID-19 hit the United States and the healthcare industry started pumping out vaccines and therapeutics, I almost instantly thought "when is Patrick Soon-Shiong going to unveil his COVID-19 solution?" NantWorks has repeatedly produced some extremely impressive product candidates for just about every major issue in healthcare. The minute the company released their press release revealing their candidates, I was looking for the market to have an immediate response both in share price and an increase in chatter. Unfortunately, it appears as if the NantWorks structure has once again caused some confusion, and the response was quite mute compared to other COVID-19 plays. It is possible that NantKwest has a therapy that can target the virus with minimal safety concerns. Is the market missing NantKwest again? Once again, it looks as if ImmunityBio has some of the primary cogwheels that are required for their COVID-19 programs, and NantKwest is just a minor player with very little to claim in the end.

Indeed, NantKwest and their NK cells appear to have a critical role in many of the NantWorks programs. However, I didn't feel reassured in the recent COVID-19 press releases. In fact, I felt as if PSS was using NantKwest's IR as a vehicle to get ImmunityBio's (a private NantWorks company) pipeline some public exposure. As a result, I would like to see some more details about NantKwest's involvement in these collaboration programs.

Back on June 24th, NantKwest announced that they intended to execute a public offering with Piper Sandler & Co., for 7.41M shares of common stock at $9.50 per share, with Piper Sandler & Co. purchasing 3.7M at $8.93 per share. What is more, PSS agreed to purchase 3.71M shares at $12.12 per share. The net proceeds are anticipated to be around $76.4M, which will be added to roughly $17M in cash and cash equivalents the company had at the end of Q1.

Typically, I am not incredibly excited about a public offering due to a negative reaction in the share price and shareholder dilution. However, I am now very bullish following the recent offering as a result of PSS willing to purchase shares at market value. It is often quite bullish to see insiders buying common stock, but it isn't common to see insiders looking buy at 52-week highs. Now, I am looking to join PSS and average up in the coming days or weeks once the technical analysis gives me the green light, and the recent volatility in the market subsides.

Admittedly, I decided to reduce my position during the January spike, but I was willing to reapply those profits once the stock was able to break out of its downtrend and cross above 200-day EMA (Green Circle on Figure 22). Now, I am waiting to see where the market is going to NK in the coming days before adding to the position. I am keeping an eye on several indicators and trend line to give me the signal to click the buy button.

Figure 2: NK Daily (Source: Trendspider)

Looking at the daily chart, we can see the stock had no problem busting through its previous 52-week high. However, the chart shows a double-top with two inside bars and an abrupt sell-off coming after the offering news. The combination of a strong bullish move followed by a negative news event will make this addition a bit tricky. I am going to wait and see if the share price is able to bounce off the red uptrend line and bust through the recent green downtrend line. Once the stock makes a decision, I am going to turn to the RSI to see if the share price remains above the green trend line and is still trading above $8.40 per share. If these conditions line up, I will make a small addition to my NK position in anticipation the stock will make another leg higher. If the share price breaks down and the RSI trend is broken, I will sell roughly half of my position and wait to see if the stock wants to retest the 200-day EMA before considering an addition.

I expect to make a few more small additions to my NK position over the course of 2020 and will leave the year with a respectable position. However, I am not going to "go-all-in" until I figure out how NantKwest will ultimately land in the NantWorks hierarchy.

Disclosure: I am/we are long NK. I wrote this article myself, and it expresses my own opinions. I am not receiving compensation for it (other than from Seeking Alpha). I have no business relationship with any company whose stock is mentioned in this article.

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NantKwest: The Market And The Government Are Missing Out On This Blockbuster - Seeking Alpha

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Image Credit: Gulf News

DUBAI: Plasma and stem cell (SC) therapies are two of the emerging star treatments being used in the fight against the SARS-CoV-2 virus.

Against COVID-19, they're considered stop-gap measures, while the world awaits a vaccine. Both, however, have proven effective against severe cases infections caused by the novel coronavirus, which has already killed over 502,000 and infected 10.1 million as of Monday (June 29, 2020).

Plasma and SC therapies have similarities, as well as obvious differences. We outline them below:

Q: What are their similarities?

Both plasma and stem cell therapies rely on rejuvenating damaged body tissue. Theyboth form part of what's described as regenerative medicine, a fast-emerging branch of medical science involving techniques thathelp restore the functionof tissues or organs.

Being regenerative treatments (or therapies), they encourage your body to use its natural abilities to heal injuries or other types of tissue damage or inflammation.

The journal Platelets refer to platelet-rich plasma (PRP) and stem cell (SC) therapies as the "mainstream medical technologies" to repair and rejuvenate a damaged tissue or organ caused by injury or chronic diseases.

Q: What are the key differences?

Plasma-rich platelets are components of blood that contain platelet concentrations above the normal level.

Platelets are the frontline workers in carrying out a healing response to injuries. They release growth factors for tissue repair.Plasma therapy uses the liquid portion of blood (plasma, yellowish) which includes a higher concentration of platelets the part of blood that contributes to clotting and healing.

Stem cells, on the other hand, are generic cells. They are the prime cells -- unspecialised, undifferentiated, immature cells. Based on specific stimuli, they can divide and differentiate into specific type of cells and tissues.

Q: What are stem cells?

Stem cells are the basic, generic building blocks of life. In a sense, they unspecialised, undifferentiated, immature cells. They can divide and differentiate into specific type of cells and tissues, based on based on specific stimuli.

Its this ability to differentiate into other types of cell that make stem cells interesting to medical science.

In adults, they are usually obtained from bone marrow. In infants, stem cells are usually taken from the umbilical cord.

Scientists have found stem cells present in blood vessels, the brain, skeletal muscles, skin and the liver.

They can be difficult to find and work with. Stem cells are also categorised by their potential to differentiate into different cell types. These include, pluripotent and multipotent stem cells.

Q: What are the advantages of stem cell-based therapies?

SCs are generic (or primitive) cells obtained either from embryos or from the adult tissues, that have the capacity of self-renewal and can differentiate into as many as 200 different cell types of the adult body.

SC also produces certain growth factors and cytokines that accelerate the healing process at the site of tissue damage. Cytokines are secreted by certain cells of the immune system and have an effect on other cells. SC is used to treat degenerative and inflammatory conditions by replacing the damaged cells in virtually any tissue or organ, where PRP applications serve no benefit.

Q: How is stem cell therapy helping fight COVID?

In the UAE, a medical research team has developed a first-in-the-world technique using inhaled stem cells that harvestedfrom the patients themselves. Following the initial success of the technique in 73 patients, the procedure has been ramped up.

In May, the ADSCC team, led by Dr Yendry Ventura, unveiled the new treatment. The UAECell19 is an autologous (cells obtained from the same individual)stem cells therapy which helped cut hospital stay from 22 days to six, relative to patients who were given standard treatment.

Q: What's the record of UAECell19 stem cell therapy?

According to the Abu Dhabi team, patients given the stem cell therapy were up to 3.1x more likely to recover in less than seven days compared to those given standard treatment.

Researchers also stated that 67% of the patients who received the stem cells treatment owed this recovery to the new treatment.

ADSCC has secured a patent for UAECell19. Protection of the intellectual property rights for the therapy opens doors for it tobe shared more widely so more patients can benefit.

Q: What is convalescent plasma?

Plasma is the liquid portion of whole blood. It is composed largely of water and proteins, and it provides a medium for red blood cells, white blood cells and platelets to circulate through the body.

Convalescent refers to a person recovering from an illness or medical treatment.

Convalescent plasma, also known as immunoglobulins, is plasma taken from the blood of a person who has recovered from a disease.

Research shows that recovered COVID-19 patients develop antibodies in the blood against the virus. Antibodies are proteins that might help fight the infection.

Q: What are platelets?

Platelets, a component of the blood, are repair agents. They are frontliners in the healing response to injuries. Platelets are also called thrombocytes, blood cells that trigger blood clotting and other necessary growth healing functions.

PLATELET FACTS

[] When the platelet count is less than 50,000, bleeding is likely to be more serious if you're cut or bruised.

[] Some people make too many platelets. They can have platelet counts from 500,000 to more than 1 million.

Q: What is platelet-rich plasma (PRP)?

PRP is a component of blood that contains platelet concentrations above the normal level -- usually five times higher concentrations of platelets above the normal values. It includes platelet-related growth factors and plasma-derived fibrinogen (a blood plasma protein that's made in the liver), among others.

Q: Has it been used to treat other diseases?

Yes. Convalescent plasma hasbeen used as a last resort to improve the survival rates of patients with SARS (2003), as well as the "Spanish Flu" (1918-1920), as well as other infectious diseases.The Lancetcitesseveral studies that showed a shorter hospital stay and lower mortality in patients treated with convalescent plasma than those who were not treated with it.

It's been gaining ground in the COVID-19 fight around the world. In the last few weeks, convalescent plasma therapy has helped treat at least 170 patients at the Infectious Disease Department at Rashid Hospital in Dubai.

THROMBOCYTOPENIA

[] This can be caused by many conditions by medicines, cancer, liver disease, pregnancy, infections (including COVID-19), and an abnormal immune system.

Q: Why is convalescent plasma important?

If you are one of the thousands of patients fully-recovered from COVID-19, you may be able to help patients currently fighting the infection by donating your plasma. That's because you fought the infection, your plasma now contains COVID-19 antibodies.

These antibodies provided one way for your immune system to fight the virus when you were sick, so your plasma may be able to be used to help others fight off the disease.

Q: I have fully recovered from COVID-19. Am I eligible donate plasma?

Yes, you are. Health authorities, including the US Food and Drug Administration, encourage people who have fully recovered from COVID-19 for at least two weeks to consider donating plasma.

You can help save the lives of other patients.

However, you must first undergo some tests to check if you're eligible to meet donor criteria. Doctors will determine that. COVID-19 convalescent plasma must only be collected from recovered individuals if you are eligible.

A lab test must document a prior diagnosis of COVID-19. In general, FDA protocol requires individuals to have complete resolution of symptoms for at least 14 days prior to donation.

Q: Is a negative lab test for COVID-19 a must before being considered to donate blood plasma?

No. The FDA guideline states: A negative lab test for active COVID-19 disease is not necessary to qualify for donation.

Q: I havent had COVID-19. What can I do to help?

You shouldconsider donating blood. One blood donation can save up to three lives.

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COVID-19: Plasma therapy vs stem cell therapy, what's the difference? - Gulf News

Recommendation and review posted by Bethany Smith

The Global Autologous Stem Cell and Non-Stem Cell Based Therapies Market is expected to exceed more than US$ 4.5 Billion by 2024 at a CAGR of 4% in the given forecast period.

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Autologous stem-cell transplantation (also called autogenetic, autogenic, or autogenic stem-cell transplantation or auto-SCT) is that the autologous transplantation of stem cellswhich is, the uniform cells or stem cells (cells from which different styles of cells develop) area unit taken from someone, accumulated, and given back to an equivalent person later. Although its most frequently dead by means that of hematogenic vegetative cells (antecedent of cells that forms blood) in hematogenic stem cell transplantation, in some cases internal organ cells square measure used profitably to mend the damages because of heart attacks.

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The Global Autologous Stem Cell and Non-Stem Cell Based Therapies Market is Segmented on the lines of Product Analysis, Application Analysis, End-User Analysis and Regional Analysis. By Product Analysis this market is segmented on the basis of BP monitoring devices, Pulmonary pressure monitoring devices and ICP monitoring devices. By Application Analysis this market is segmented on the basis of Treating neurodegenerative, Autoimmune, Cardiovascular disorders skin transplant, Oncology and Other.

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Table of Contents

1 INTRODUCTION

2 EXECUTIVE SUMMARY

3 AUTOLOGOUS STEM CELL & NON STEM SELL THERAPY -TECHNOLOGY LANDSCAPE ANALYSIS

4 AUTOLOGOUS STEM CELL & NON STEM SELL THERAPY TECHNOLOGY INVESTMENT POTENTIAL

4.1 INVESTMENT CLIMATE ASSESSMENT4.1.1 INVESTOR NETWORKS4.1.1.1 PUBLIC FUNDING BODIES4.1.1.2 FUNDING/GRANTS FROM NGO ORGANIZATIONS4.1.1.3 PRIVATE INVESTORS AND VENTURE CAPITAL FIRMS4.1.1.4 INSIGHTS ON CURRENT AND FUTURE TECH-INVESTMENT TRENDS4.1.1.5 INVESTOR INCLINATION AND PATTERNS4.2 INVESTMENT OPPURTUNITIES4.2.1 LICENSING AND ACQUISITION4.2.2 ANALYSIS OF POTENTIAL APPLICATION AREAS FOR TECHNOLOGY INVESTMENT

5 AUTOLOGOUS STEM CELL MARKET LANDSCAPE ANALYSIS

6 AUTOLOGOUS STEM CELL & NON STEM SELL THERAPY TECHNOLOGY ADOPTION POTENTIAL AND DEVELOPMENT BY GEOGRAPHY

7 COMPETITIVE LANDSCAPE

8 PATENT ANALYSIS

9 TECHNOLOGY ANALYSIS AND ROAD MAPPING

10 ANALYST INSIGHTS AND RECOMMENDATIONS

11 COMPANY PROFILES

11.1 ANTRIA (CRO) (U.S.)

11.2 BIOHEART (U.S.)

11.3 BRAINSTORM CELL THERAPEUTICS (U.S.)

11.4 CYTORI (U.S.)

11.5 DENDREON CORPORATION (U.S.)

11.6 FIBROCELL (U.S.)

11.7 GENESIS BIOPHARMA (U.S.)

11.8 GEORGIA HEALTH SCIENCES UNIVERSITY (U.S.)

11.9 NEOSTEM (U.S.)

11.10 OPEXA THERAPEUTICS (U.S.)

11.11 ORGENESIS (U.S.)

11.12 REGENEXX (U.S.)

11.13 REGENEUS (AUSTRALIA)

11.14 TENGION (U.S.)

11.15 TIGENIX (BELGIUM)

11.16 VIRXSYS (U.S.)

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Autologous Stem Cell and Non-Stem Cell Based Therapies Market 2020: Challenges, Growth, Types, Applications, Revenue, Insights, Growth Analysis,...

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Amniotic Membrane Market by Product, Application and Forecast to 2027 TMR - 3rd Watch News

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On February 67, 2020, the Simons Foundation Autism Research Initiative (SFARI) convened a two-day workshop to explore the possibility of gene therapies for autism spectrum disorder (ASD), a neurodevelopmental condition associated with changes in over 100 genes. Inspired by the recent, stunning successes of gene therapy for the fatal neuromuscular disorder spinal muscular atrophy (SMA)1, and by the accumulation of genes confidently associated with ASD2, SFARI welcomed a diverse collection of researchers to begin to think about whether a similar approach could be taken for ASD. Because gene therapy attempts to fix what is broken at the level of a causative gene, it would offer a more direct and imminent strategy than mitigation of the many and as yet mostly unclear downstream effects of a damaged gene.

The workshop was organized in 20 talks and several discussion panels, which tackled many outstanding issues, including how to choose candidate target genes and predict outcomes; how to optimize vectors for gene delivery; how to decide when to intervene; which animal models to develop; how to find appropriate endpoints for clinical trials and understand the available regulatory pathways. SFARI also raised the question of how its funding might best propel gene therapy efforts amid the emerging, complex ecosystem of academic laboratories, biotech companies, and pharmaceutical industries.

Even the opportunity to have this discussion is very rewarding, said SFARI Investigator Matthew State of the University of California, San Francisco (UCSF), one of the investigators who directed teams of geneticists to analyze the Simons Simplex Collection (SSC).

These efforts have offered up multiple potentially feasible therapeutic targets. Though rare, de novo disruptive mutations in the highest confidence ASD genes often result in severe impairment characterized not only by social difficulties, but also by intellectual disability and seizures. The combination of a single gene mutation of large effect coupled with particularly severe outcomes that include ASD are likely to offer the most immediate targets for gene therapy. For now, this leaves out a large number of individuals with autism for whom genetic causes are not yet known and are likely the result of a combination of many small effect alleles across a large number of genes.

Highlights from talks and discussion panel, chaired by Rick Lifton of Rockefeller University

In the first talk of the workshop, State brought the group up to speed on ASD genomics. The most recent tally from exome-sequencing in simplex cases of ASD highlighted 102 genes in which rare mutations confer individually large risks2. In contrast, the task of identifying common variants carrying very small risks remains quite challenging, with less than a half dozen alleles so far identified with confidence3. The rare, disruptive mutations that result in loss of function of one gene copy are an attractive focus for gene therapy because of the tractability of targeting a single spot in the genome per individual and because, in the vast majority of cases, there remains a single unchanged allele. This points to ways to boost gene and/or protein expression back toward the normal state by leveraging the unaffected copy. But both the limited number of cases known so far combined with the possibility that different mutations to the same gene may have different effects complicate thinking about how to prioritize targets for gene therapy.

State made several points that were continually touched on throughout the workshop. Many ASD genes are highly expressed during midfetal development in the cortex, and additional experiments will need to determine whether and how long a window of opportunity may be present for successful gene therapy postnatally. Given the relatively small number of people with these conditions, new clinical trial designs are needed that dont rely on comparisons between large control and intervention groups (see also Bryan Kings talk below).

Beyond the gene-crippling mutations found in the exome, disruptions to transcription may also dramatically raise risk for autism and may be corrected with a type of gene therapy using ASOs. SFARI Investigator Stephan Sanders of UCSF focused on the role of splicing, the process by which an initial transcript is turned into messenger RNA by removal of introns and joining together of exons. Splicing is disrupted in at least 1.5 percent of individuals with ASD4, and possibly many more, as suggested by transcript irregularities found in postmortem autism brain5. Sanders described Illuminas Splice AI project in which machine-learning helps predict noncoding variants that can alter splicing, including those beyond typical splice sites found near a gene6. As a result of incorporating sequence information around and between splice sites, this computational tool detected more mutations with predicted splice-altering consequences in people with ASD and intellectual disability than in those without the condition.

An ASO designed to bind specific portions of RNA could conceivably correct errors in transcription. ASOs have already been approved for use in other disorders in order to skip exons, retain exons or to degrade mRNA. Unlike other forms of gene therapy, ASOs do not permanently alter the genome, making it a kind of gene therapy lite. This reversibility has both disadvantages (having to re-infuse the ASO every few months) and advantages (multiple opportunities to optimize the dose and target; serious adverse effects are not permanent).

Jonathan Weissman of UCSF discussed the available toolbox for controlling gene expression developed by many different laboratories. To turn genes on or off, he has developed a method to combine CRISPR with an enzymatically inactive (dead) Cas9, which can then be coupled with a transcriptional activator (CRISPRa) or repressor (CRISPRi)7 (Figure 2). In the case of loss-of-function mutations, Weissman outlined strategies to make the remaining good allele work harder: increase transcription via CRISPRa, decrease mRNA turnover, increase translation of a good transcript via modification of upstream open reading frames (uORFs) or increase a proteins stability, possibly through small molecules acting on the ubiquitin system8. That said, the effects on a cell may be complicated. Using Perturb-Seq screens, Weissman described genetic interaction manifolds that show nonlinear mapping between genotype and single cell transcriptional phenotypes9. Additionally, Weissman summarized recent work from his laboratory that has identified large numbers of uORFs that result in polypeptides, some of which affect cellular function.

SFARI Investigator Michael Wigler of Cold Spring Harbor Laboratories echoed the idea of a gene-therapy strategy that increases expression of the remaining good copy of a gene, especially given that in his estimate, 45 percent of simplex cases of autism carried a de novo, likely disrupting variant. He also called attention to the uterine environment, especially the challenge posed by expression of paternally derived antigens in the fetus and the impact of a potential maternal immune response, and the need to understand how it interacts with de novo genetic events.

Highlights from talks and discussion panel, chaired by Arnon Rosenthal of Alector

The discussion turned to finding ways of getting genes into the central nervous system. The AAV is the darling of gene therapy, given that it does not replicate and is not known to cause disease in humans. A version that can cross the blood-brain barrier (AAV9) was used to deliver a gene replacement to children with SMA intravenously; though this effectively delivered the genetic cargo to ailing motor neurons in the spinal cord, it does not work that well at delivering genes throughout the brain.

Ben Deverman of the Stanley Center at the Broad Institute of MIT and Harvard detailed his efforts to optimize AAV for efficient transduction of brain cells through a targeted evolution process: his team engineers millions of variants in the capsid of the virus, then screens them for entry into the nervous system and transduction of neurons and glia. This has yielded versions (called AAV-PHP.B and AAV-PHP.eB) that more efficiently enter the brain10,11. One successfully delivered the MECP2 gene to the brain of a Rett syndrome mouse model, resulting in ameliorated symptoms and an extended lifespan12. Unfortunately, these viruses dont work in human cells or in all mouse strains. A quick mouse genome-wide association study (GWAS) revealed that the Ly6a gene mediates efficient blood-brain barrier crossing of AAV-PHP.B and AAV-PHP.eB13. Now his group has identified Ly6a-independent capsids that may translate better to humans. He also noted that the PHP.B vectors have tissue specificity for brain and liver.

With an estimated 87 percent of autism-associated genes raising risk through haploinsufficiency (having only one functional gene copy out of the two), SFARI Investigator Nadav Ahituv of UCSF made the case for approaches that boost expression of the remaining good copy of a gene through endogenous mechanisms a strategy he called cis-regulation therapy. This method also provides a way to work around the small four kb payload of AAV, which strains to contain cDNA of many autism genes. A recent study by his group used CRISPRa targeted at an enhancer or promoter of SIM1 and promoter of MC4R, both obesity genes, in mice. Using one AAV vector for a dCas9 joined to a transcription activator, and another AAV vector having a guide RNA targeting either a promoter or an enhancer, and a guide RNA targeting a promoter, the researchers injected the vectors together into the hypothalamus, which resulted in increased SIM1 or MC4R transcription and reversed the obesity phenotype brought on by loss of these genes14. Targeting regulatory elements had the added benefit of tissue specificity, and there seemed to be a ceiling effect for SIM1 expression, which suggested an endogenous safeguard against overexpression at work. He is now collaborating with SFARI Investigator Kevin Bender, also at UCSF, to apply this approach to the autism gene SCN2A.

Botond Roska of the Institute of Molecular and Clinical Ophthalmology in Basel, Switzerland pointed out that getting genes to the cells where they are needed is crucial when treating eye diseases. Off-target effects there can induce degeneration of healthy cells. For this reason, Roska and his group have created AAVs that target specific cell types in the retina by developing synthetic promoters that efficiently promote expression of the viruss cargo15. The promoters they designed were educated guesses based on four approaches: likely regulatory elements close to genes expressed with cell-type specificity in the retina, conserved elements close to cell typespecific genes, binding sites for cell typespecific transcription factors and open chromatin close to cell typespecific genes. Screening a library of these in mouse, macaque and human retina revealed some with high cell-type specificity (Figure 3). Importantly, macaque data predicted success in human retina much better than did mouse data. In preliminary experiments, and more relevant to gene therapy for ASD, these cell-specific vectors also had some success in mouse cortex, for example lighting up parvalbumin neurons or an apparently new type of astrocyte.

Roska also described new methods for delivery, in which nanoparticles are coated with AAV, then drawn into the brain using magnets16. This magnetophoresis technique allows a library of experimental AAVs to be tested at the same time in one monkey. Steering nanoparticles with magnets gives more control of vector placement and gene delivery. He argued that these in the future could access even deep structures of the brain.

Highlights from talks and discussion panel, chaired by Steven Hyman of the Broad Institute at MIT and Harvard

Kathy High of Spark Therapeutics reviewed the story of gene therapy for spinal muscular atrophy (SMA) type 1. Though she was not directly involved in that research, she is well aware of the regulatory atmosphere surrounding gene therapy, given that Spark Therapeutics developed the first approved AAV-delivered gene for a form of retinal dystrophy. The SMA story is a useful case study in that an ASO-based therapy (nusinersen, marketed as Spinraza), approved in 2016, set the stage for a gene-replacement therapy, marketed as Zolgensma (onasemnogene abeparvovec). Ultimately, the amount of data supporting Zolgensmas approval was modest: a Phase one dose study of 15 infants1, and an ongoing Phase three trial of 21 infants and safety data from 44 individuals. Yet the approval was helped by the dramatic results and clear endpoints: those receiving a single intravenous infusion of an AAV9 vector containing a replacement gene all remained alive at 20 months of age, whereas only 8 percent survived to that age in the natural history data, which compiles the diseases untreated course. High mentioned that maintaining product quality for gene therapeutics may prove trickier than for typical medications.

The attractive, highly customizable nature of gene therapy might have a regulatory downside in that different vector payloads, even when designed to do the same thing, could invite separate approval processes. Though not knowing how regulatory agencies would view this, High said that their perspectives are bound to evolve as more gene therapy trials are completed.

Getting to ASD-related syndromes, Bender talked about SCN2A, which encodes the sodium channel Nav1.2. SCN2A mutations in humans can be gain of function or loss of function; gain-of-function mutations are associated with early onset epilepsy, and loss-of-function mutations with intellectual disability and ASD. In a mouse model missing one copy of SCN2A, Bender and his group have discovered a role for SCN2A in action potential generation in the first week after birth, and in synaptic function and maturation afterward through regulation of dendritic excitability18 (Figure 4). Using AAV containing CRISPRa constructs developed with the Ahituv lab, the researchers successfully increased SCN2A expression, and recovered synapse function and maturity, even when done several weeks postnatally. Getting the appropriate dosage is critical since gain-of-function mutations are linked to epilepsy. However, Bender reported even when SCN2A expression increased to double normal levels, no hints of hyperexcitability appeared. We might be able to overdrive this channel as much as we want and actually may not have risk of producing an epileptic insult, he said. Next steps are to figure out the developmental windows for intervention, evaluate changes in seizure sensitivity and extend this kind of cis-regulatory approach to other ASD genes.

Angelman syndrome is another condition that attracts interest for gene therapy, in part because neurons already harbor an appropriate replacement gene. Angelman syndrome stems from mutations to the maternally inherited UBE3A gene, which is particularly damaging to neurons because they only express the maternal allele, while the paternal allele is silenced by an antisense transcript. SFARI Investigator Mark Zylka of the University of North Carolina and colleagues showed in 2011 that this paternal allele could be unsilenced with a cancer drug in a mouse model of Angelman syndrome19. Since then, three companies have built ASOs to do the same thing, and these are going into clinical trials. To get a more permanent therapeutic, Zylka has been developing CRISPR/Cas9 systems to reactivate paternal UBE3A, and preliminary experiments show that injecting this construct into the brains of embryonic mice, and then again at birth, results in brain-wide expression of paternal UBE3A and is long-lasting (at least 17 months). Zylka is now making human versions of these constructs. He later noted rare cases of mosaicism for the Angelman syndrome mutation people with 10 percent normal cells in blood have a milder phenotype20, which suggests that even inefficient transduction of a gene vector could help.

Zylka also made a case for prenatal interventions in Angelman syndrome: studies of mouse models indicate that early reinstatement of UBE3A expression in mouse embryos rescues multiple Angelman syndrome-related phenotypes, whereas later postnatal interventions rescue fewer of these21; for humans, a diagnostic, cell-based, noninvasive prenatal test will be available soon22; ultrasound-guided injections into fetal brain of nonhuman primates have been developed23; prenatal surgeries are now standard of care for spinal bifida; and intervening prenatally decreases the risk of an immunogenic response to an AAV vector or its cargo. During the discussion, it was noted that another benefit of acting early was that less AAV would be needed to transduce a much smaller brain; however, a drawback is the lack of data on Angelman syndrome development from birth to one year of age. This natural history would be necessary for understanding whether a prenatal therapy is more effective than treatment of neonates.

SFARI Investigator Guoping Feng of the Massachusetts Institute of Technology has been investigating SHANK3, a high-confidence autism risk gene linked to a severe neurodevelopmental condition called Phelan-McDermid syndrome, which is marked by intellectual disability, speech impairments, as well as ASD. SHANK3 is a scaffold protein important for organizing post-synaptic machinery in neurons. Mouse studies by Feng have shown that SHANK3 re-expression in adult mice that have developed without it can remedy some, but not all, of their phenotypes, including dendritic spine densities, neural function in the striatum and social interaction24. Furthermore, early postnatal re-expression rescued most phenotypes. This makes SHANK3 a potential candidate for gene therapy; however, it is a very large gene 5.2kb as a cDNA that is difficult to fit into a viral vector. To get around this, Fengs group has designed a smaller SHANK3 mini-gene as a substitute for the full-sized version. Preliminary experiments show that AAV delivery of the mini-gene can rescue phenotypes like anxiety, social behavior and corticostriatal synapse function in SHANK3 knockout mice. Feng also discussed his success in editing the genome in marmosets and macaques using CRISPR/Cas9 technology and showed data from a macaque model of SHANK3 dysfunction25. These models may help test gene therapy approaches and identify biomarkers of brain development closely related to the human disorder.

For people with rare conditions brought on by even rarer mutations, individualized gene therapies can provide a pathway for treatment. SFARI Investigator Timothy Yu of Boston Childrens Hospital/Harvard described his N-of-1 study in treating a girl with Batten disease, a recessive disorder in which a child progressively loses vision, speech and motor control while developing seizures. In a little over a year, an ASO that targeted her unusual splice-site mutation in the CLN7 gene was designed, developed and given intrathecally to the girl26. The lift was in negotiating with the FDA and working with private organizations, not just in the science, Yu said. After a year of treatment with the ASO (dubbed milasen after the girl, Mila), there were no serious adverse events; seizure frequency and duration had decreased (Figure 5); and possibly her decline had slowed. Though she remains blind, without intelligible speech and unable to walk on her own, she was still attentive and could respond happily to her familys voices. The highly personalized framework for this drugs approval is completely different from how medications meant for populations are approved, and it opens a regulatory can of worms, Yu said, though he added that the regulators were willing to countenance drug approval for an individuals clinical benefit.

Rett syndrome is a neurodevelopmental condition caused by mutations to the MECP2 gene that has a substantial research base in mouse models. Over 10 years ago, mouse models highlighted the possibility for therapeutics in this condition when Rett-associated phenotypes were rescued by adding back MECP2, even in adulthood27. This reversibility has spurred interest in gene therapy for Rett syndrome, but getting the MECP2 dose right is critical, said Stuart Cobb of the University of Edinburgh and Neurogene: just as too little MECP2 leads to Rett syndrome, too much also results in severe phenotypes. For this reason, it would be nice to package a replacement MECP2 gene with other regulatory elements to control its expression, but this results in constructs that do not fit into viral vectors. To make more room, Cobb and his colleagues have been able to chop away two-thirds of the MECP2, reserving two domains that interact to make a complex on DNA (Figure 6). Mice with this mini-gene are viable and have near normal phenotypes; likewise, injecting this mini-gene into MECP2-deficient mice extended their survival28. Doubling the dose, however, substantially lowered survival. Putting in safety valves to prevent overexpression is going to be quite important, he said. One idea is to add back a construct containing only the last two exons of MECP2, which is where most Rett mutations land. These would then be spliced into native transcripts (called trans-splicing), and thus their expression controlled by endogenous regulatory elements.

Underscoring the double-edged sword of MECP2 dosage, Yingyao Shao from Huda Zoghbis lab at Baylor described an MECP2 duplication syndrome (MDS) in humans, which features hypotonia, intellectual disability, epilepsy and autism. Experiments in an MDS mouse model, which carries one mouse version and one human version of MECP2, recapitulates some of the phenotypes of the human condition and can be rescued by an ASO targeting the human allele29. Shao described work to optimize the ASO for translation into humans, which involved developing a more humanized MDS model that carries two human MECP2 alleles. An acute injection of the ASO was able to knock down MECP2 expression in a dose-dependent manner in these mice, and RNA levels dropped a week after injection, with protein levels falling a week later. MECP2 target genes also normalized their expression level, and one maintained this for at least 16 weeks post-injection. The ASO also rescued behavioral phenotypes of motor coordination and fear conditioning, but not of anxiety; these corrections followed the molecular effects, and these timelines would be important to keep in mind while designing clinical trials. Shao also noted that overtreatment with the ASO resulted in Rett-associated phenotypes, but that this was reversible, which suggests that some fine-tuning of dosing in humans might be possible.

To avoid overtreatment and toxicity of any MDS-directed therapy, Mirjana Maletic-Savatic, also at Baylor, is leaving no stone unturned in a hunt for MDS biomarkers that can predict, in each individual, the safety of a particular dose and regimen. Such biomarkers would also help monitor individuals during treatment, give information about target engagement and identify candidates for a particular treatment. Anything found to be sensitive to expression levels of MECP2 could also be useful for Rett, though she noted that MECP2 levels measured in blood do not track linearly with gene copy number. Thus, because of interindividual variability, her approach is to collect a kitchen sink of data deriving composite biomarkers that accurately reflect the stage and severity of disease in a given case. She and her colleagues are collecting clinical, genetic, neurocircuitry (such as EEG and sleep waves), immunology and molecular data detected in blood, urine and CSF. These measures are also being explored in induced neurons derived from skin samples of people with MDS. She highlighted two interrelated potential biomarkers in the blood of those with this condition; both measures are downstream targets of MECP2 and are responsive to ASO treatment.

Highlights from Early detection and clinical trial issues talks and panel discussion, chaired by Paul Wang of SFARI

Coming up with objective measures of a persons status either their eligibility for a treatment, or whether the treatment has engaged with its target or even whether the treatment is effective is a real necessity in autism-related conditions, which comprise multiple interrelated behaviors. Eye-tracking methodology may provide such a marker, argued SFARI Investigator Ami Klin of Emory University. Focusing on the core social challenges of autism, Klin, Warren Jones and colleagues have been studying children as they view naturalistic social scenes to quantify their social attention patterns. This has revealed how remarkably early in development social visual learning begins and that this process is disrupted in infants later diagnosed with ASD prior to features associated with the condition appearing. By missing social cues, autism in many ways creates itself, moment by moment, Klin said. In considering gene therapy, it may be useful to know that eye looking (how much a subject looks at a persons eyes, an index of social visual engagement) in particular and social visual engagement in general are under genetic control30; that eye-tracking differences emerge as early as 26 months of age; and that homologies in social visual engagement exist between human babies and nonhuman infant primates.

In getting to a point to test gene therapies, identifying those who need them is essential. Wendy Chung of Columbia University and the Simons Foundation illustrated how diagnosis is yoked closely to therapy. To illustrate this, she described her pilot study of newborn blood spots to screen for SMA; at the start, no treatment was available, but the screen identified newborns for a clinical trial of nusinersin. Notably, the screen only cost an additional 11 cents per baby. In the three years since her pilot screen began, the FDA approved two gene therapies for SMA and the SMA screen was adopted for nationwide newborn screening. Currently she is piloting a screen for Duchenne muscular dystrophy and plans to develop a platform that will allow researchers to add other conditions. In prioritizing genetic conditions for gene therapy, she outlined some ideas for focus, such as genes resulting in phenotypes that would not be identified early without screening, those that are relatively frequent, those that are lethal or neurodegenerative, those with a treatment in clinical trials or with FDA-approved medications, and those conditions that are reversible.

In the meantime, Chung also outlined SFARIs involvement in establishing well-characterized cohorts of individuals with autism, which can help lay a groundwork for gene therapy. People with an ASD diagnosis can join SPARK (Simons Foundation Powering Autism Research for Knowledge), which collects medical, behavioral and genetic information (through analysis of DNA from saliva, at no cost to the participant). If a de novo genetic variant is found in one of ~150 genes, that person is referred to Simons Searchlight, which fosters rare conditions communities and which is also compiling natural history data on people with these mutations.

Bryan King of UCSF discussed how current trial designs for ASD were inadequate for gene therapy trials. As ASD prevalence has grown, parallel design trials with one group receiving an experimental medicine and the other a placebo are the standard, but these wont be possible for the rare conditions that are candidates for gene therapy. Also, change is hard to capture, given the malleable nature of ASD: with no intervention, diagnosis can shift between ASD and pervasive developmental disorder-not otherwise specified (PDD-NOS) in 1284 months (as defined by the DSM-IV). Current scales are subjective and may miss specific items of clinical significance. (Last year, SFARI funded four efforts to develop more sensitive outcome measures.) King outlined other pitfalls in ASD clinical trials, including significant placebo responses, inadequate sample sizes and not being specific enough when asking about adverse effects. King also mentioned improvements that may arise from just enrolling in a study, which could prompt previously housebound families to venture out with their child, which could kick off a cascade of positive effects. He reiterated how, for gene therapy, a natural history comparison group may be more appropriate, combined with solid outcome measures.

SFARI Investigator James McPartland of Yale University then underlined the need for objective biomarkers for clinical trials, for which there are currently none that are FDA qualified for ASD. As the director of the Autism Biomarkers Consortium for Clinical Trials (ABC-CT), he works with other scientists to develop reliable biomarkers that can be scaled for use in large samples across different sites. McPartland noted a biomarker studied in the ABC-CT: an event-related potential (N170) to human faces, which is on average slower in ASD than in typically developing children. He is working on ways to make it easier for people with ASD and intellectual disabilities to participate in biomarker studies and to make them more socially naturalistic. In discussion, he mentioned he thought it would be possible to look for these kinds of biomarkers in younger children.

SFARI Investigator Shafali Jeste of the University of California, Los Angeles recounted her experience in working with children with genetic syndromes associated with neurodevelopmental conditions. Though she is asked to participate in clinical trials for these conditions, she senses the field has some work to do to be ready for these trials, particularly in those with additional challenges such as epilepsy and intellectual disability. Meaningful and measurable clinical endpoints are still insufficient, and there needs to be more ways to improve accessibility of these trials for these rare conditions. This means developing new measures, such as gait-mat technology that senses walking coordination, or EEG measures in waking and sleep, which have been applied to people with chromosome 15q11.2-13.1 duplication (dup15q) syndrome, who have severe intellectual disability and motor impairments. Jeste also emphasized that increasing remote access to some measures can make a big difference for a trial; for example, a trial of a behavioral intervention for tuberous sclerosis complex that required weekly lab visits was disappointingly under-enrolled until researchers revamped it so most of the intervention could be done remotely31.

By grappling with the challenges to gene therapy for ASD, the workshop marked out a faint road map of a way forward. As the scientific questions are answered, the regulatory and clinical trial infrastructure will need to develop apace, and coordination between private, academic and advocacy sectors will be essential. But as gene therapy for diverse human conditions continues to be explored and gene discovery in ASD continues, there is reason to believe that some forms of ASD can eventually benefit from this strategy.This workshop provided a terrific discussion about the challenges in developing targeted gene interventions and their potentially transformative effects as therapies, said John Spiro, Deputy Scientific Director of SFARI. We are grateful to all theparticipants, and SFARI looks forward to translating these discussions into focused funding decisions in the near future.

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Recommendation and review posted by Bethany Smith

Two rounds totalling $83 million have propelled Surrozen through preclinical proof-of-concept, culminating in two antibody candidates modulating the Wnt pathway for tissue regeneration. Now, the South San Francisco biotech is topping up $50 million to complete the sprint to the clinic.

One of the two IND candidates targets liver disease while the other will be initially positioned for inflammatory bowel disease. With the cash infusion, Surrozen can also pursue more discovery projects in different tissues and areas.

Our goal is to file IND applications in 2021 and 2022, CEO Craig Parker said in a statement, 5 and 6 years after the company first set out to catch and push a second wave of regenerative medicine.

Christopher Garcia and Roeland Nusse, two Stanford professors, provided some of the scientific legs for the company. Aside from its role in cancer, Wnt a portmanteau integrating Wingless and Int-1 signaling is also key to the control of cell development and regeneration, but the instability means they are hard to manufacture. As Nusse elucidated crucial aspects of Wnt biology, Garcia inspired the idea to activate or enhance response to endogenous Wnts, through either bispecific or antibody-based molecules.

While it has long been known that the Wnt signaling pathway plays a crucial role in the maintenance and self-renewal of stem cells in a variety of tissues, scientists had been unable to overcome the technical challenges inherent in developing a therapeutic based on Wnt signaling, Nusse, the Virginia and Daniel K. Ludwig Professor of Cancer Research and Professor of Developmental Biology, said. I am hopeful that Surrozens approach to modulating the Wnt pathway, with the flexibility to address insufficient endogenous Wnt or insufficient receptors, may someday lead to therapeutics that have the potential to repair damaged tissue.

Claudia Janda, a postdoc at Garcias lab whos since moved on to the Princess Mxima Center for Pediatric Oncology, remains a scientific advisor alongside Princess Mxima director Hans Clevers and Stanfords Calvin Kuo.

Both tech platforms were represented in the lead nominated candidates.

SZN-043 was designed on SWEETS, or Surrozen Wnt signal enhancers engineered for tissue specificity. Through stabilizing the Frizzled receptors that Wnt proteins signal through, the compound was shown to stimulate hepatocyte proliferation in the liver and reduce fibrosis something that should be helpful in conditions like severe acute alcoholic hepatitis or even cirrhosis.

The possibilities are almost endless, with Surrozen spelling out potential applications in NASH and decompensated liver disease.

SZN-1326, meanwhile, was born out of SWAP (Surrozen Wnt signal activating proteins). The molecule binds to Frizzled receptors directly and should stimulate regeneration of intestinal epithelial cells. Researchers also noted anti-inflammatory effects in animal models.

It is still a ways from human data. But old investors are returning to take that leap with Surrozen, including The Column Group, Hartford Healthcare Trust and Horizons Ventures. Euclidian Capital and three other new believers are jumping on board.

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Surrozen reloads with $50M for final dash to the clinic, shines some light on lead Wnt-modulating candidates - Endpoints News

Recommendation and review posted by Bethany Smith

Mostpeople know breastfeeding is one of the best ways to help a baby thrive. And now it seems a mother's milk has beneficial effects even when her child reaches adulthood.

New University of Toronto research has found that if people genetically at risk of becoming obese are exclusively breastfed as a baby it can help ward off weight gain when they're young adults.

The study is part of a growing body of evidence about the benefits of breastfeeding yet the World Health Organisation says nearly two out of three infants aren't exclusively breastfed for the recommended six months a rate that hasn't improved in 20 years.

READ MORE:Leona O'Neill: I'm very nervous about prospect of sending my children back to school

When asked, 80 per cent of the women who stopped breastfeeding before six months said they would have liked to continue for longer, but often lacked support and guidance.

"Our society is letting mothers down there needs to be much more investment in breastfeeding support and education," says NCT breastfeeding counsellor Cordelia Uys, a breastfeeding expert for the holistic new mums' wellness app Biamother (biamother.com).

"Breastfeeding confers numerous health protections on both mother and child and creates a strong sense of emotional connection. In addition, for a mother to see her baby growing and thriving on her milk can be one of the most satisfying and rewarding experiences of her life."

Here, Uys outlines ten surprising breastfeeding facts...

1. Breast milk is personalised medicine

There are numerous antiviral and antibacterial properties in breast milk that protect a baby from infection. These infection-fighting properties are being continually updated in response to the mother and baby's environment. When a mother's body encounters a new germ, her mature immune system will deploy millions of white blood cells to fight it off and quickly pass them on to her baby via her milk.

2. Breast milk contains stem cells

Every time a mother breastfeeds her baby, stem cells in her breast milk cross the baby's gut and into their blood, and then travel to all the baby's organs, including their brain. These stem cells are capable of becoming functioning cells all over the infant's body. It's believed they can boost and support the infant's optimal development and protect them against infectious diseases.

With antiviral and antibacterial properties, breast milk is personalised medicine, for one thing

3. Breastfeeding has to be learned

Many people think breastfeeding will come naturally to mothers, but in fact, for all female apes, breastfeeding is a learned behaviour. A juvenile female gorilla in Ohio Zoo, having been separated from her mother at a young age, had no idea how to feed her first baby. But during her second pregnancy, zookeepers had the inspired idea of asking human mothers to regularly breastfeed their babies in front of her. When her second baby was born, the gorilla immediately picked it up and put it to the breast.

In the past, human mothers would have learned how to breastfeed by watching relatives and friends. For this reason, it's a good idea for pregnant women who want to breastfeed, to spend some time with a friend who's successfully nursing her baby. The National Breastfeeding Helpline and apps can also offer advice on breastfeeding.

4. Over 95 per cent of women can produce all the milk their baby needs

The vast majority of women can make all the milk their baby needs and, contrary to popular belief, the size of a woman's breasts doesn't impact the volume of milk she can produce.

Milk production depends entirely on supply and demand: in the early months, milk needs to be removed effectively from both her breasts at least eight times in 24 hours for a mother's supply to be established and maintained. By far the most common reason for low milk supply is under-stimulation of a mother's breasts, either because her baby isn't feeding frequently enough or isn't removing milk effectively.

5. Breastfeeding acts as a natural painkiller

Breast milk contains natural painkillers called endocannabinoids. Breastfeeding before and during vaccination injections has been shown to reduce pain in babies.

6. Breastfeeding protects mothers against breast cancer

The Tanka Fisherwomen of Southern China traditionally only breastfeed their babies from their right breast. In the early 1970s, a medical student at a Hong Kong clinic noticed that if Tanka women developed breast cancer, in 79 per cent of cases, it was in their left breast. It was this observation that led to the discovery that breastfeeding is protective against breast cancer.

Breastfeeding expert Cordelia Uys

7. Breastfeeding shouldn't hurt

Pain is there to tell us something is wrong, and this is true for breastfeeding too. Pain and damage happen when a mother's nipple isn't positioned correctly in her baby's mouth. In the majority of cases, when a baby is well-positioning and deeply latched, breastfeeding will be completely comfortable. If breastfeeding hurts, it's important to seek out qualified support as soon as possible.

8. The temperature of a mother's breasts adapts to her baby's needs

A mother's breasts can warm up by 2C if the baby is too cold, and cool down by 2C if the baby is too hot. In fact, it has been shown that when newborn twins are placed in skin-to-skin contact with their mother, each of her breasts will heat up to a different temperature according to each baby's needs. This is called thermal synchrony.

9. Breastfeeding mothers get more sleep

Studies have shown breastfeeding mothers sleep on average 45 minutes more a night than mothers who formula feed. Human milk contains substances that promote sleep and calmness in babies. Mothers release the hormone prolactin into their own blood while breastfeeding, which helps them to fall asleep more easily.

10. Breastfeeding is carbon neutral

When a mother is breastfeeding, there is zero waste and no carbon emissions. Research at Imperial College London has shown breastfeeding for six months saves an estimated 95-153kg CO2 equivalent per baby compared with formula feeding.

:: National Breastfeeding Helpline (nationalbreastfeedinghelpline.org.uk): 0300 100 0212

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Recommendation and review posted by Bethany Smith

Global Predictive Genetic Testing Market Analysis with forecast period 2020 to 2025 provides an in-depth analysis of market growth factors, future assessment, country-level analysis, Predictive Genetic Testing industry distribution, and competitive landscape analysis of major industry players. The research report of global Predictive Genetic Testing market report offers the extensive information about the top most makers and sellers who are doing great and are directly working right in the market now and which have great market area according to the country and region and other aspects that affect the growth of any company or industry.

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Agilent, Technologies, Inc., BGI Genomics, F.Hoffman-La Roche Ltd., Genes In Life., Invitae Corporation, Illumina, Inc., 23andMe, Myriad Genetics, Inc., Pathway Genomics and Thermo Fisher Scientific, Inc.

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Global Predictive Genetic Testing market report estimates the revenue, industry size, types, applications, players share, production volume, and consumption to get an understanding of the demand and supply chain of the market. The report encompasses technical data, raw materials, volumes, and manufacturing analysis of the global Predictive Genetic Testing market. The research study delivers future projections for prominent opportunities based on the analysis of the subdivision of the market. The study meticulously unveils the market and contains substantial details about the projections with respect to industry, remuneration forecast, sales graph, and growth prospects over the forecast timeline.

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Prenatal Genetic Testing Market report provides (6 Year Forecast 2020-2026) including detailed Coronavirus (COVID-19) impact analysis on Market Size, Regional and Country-Level Market Size, Segmentation Market Growth, Market Share, Competitive Landscape, Sales Analysis and Value Chain Optimization. This Prenatal Genetic Testing market competitive landscape offers details by topmost key manufactures (Sequenom Laboratories, Illumina, Natera, Ariosa Diagnostics, BGI Health, Natera, LifeCodexx) including Company Overview, Company Total Revenue (Financials), Market Potential, Presence, Prenatal Genetic Testing industry Sales and Revenue Generated, Market Share, Price, Production Sites and Facilities, SWOT Analysis, Product Launch. For the period 2014-2020, this study provides the Prenatal Genetic Testing sales, revenue and market share for each player covered in this report.

Key Target Audience of Prenatal Genetic Testing Market: Manufacturers of Prenatal Genetic Testing, Raw material suppliers, Market research and consulting firms, Government bodies such as regulating authorities and policy makers, Organizations, forums and alliances related to Prenatal Genetic Testing market.

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Synopsis of Prenatal Genetic Testing Market:In 2018, the global Prenatal Genetic Testing market size was million US$ and it is expected to reach million US$ by the end of 2025, with a CAGR of during 2019-2025.

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Diagnostic Test Chorionic Villi Sampling (CVS) Amniocentesis Placental Biopsy Cordocentesis Fetal Biopsy Screening Test Carrier Screening Sequential Screening Maternal Serum Quad Screening

Based onend users/applications, Prenatal Genetic Testing market report focuses on the status and outlook for major applications/end users, sales volume, market share and growth rate for each application, this can be divided into:

Hospitals Clinics Diagnostic Centers

Prenatal Genetic Testing Market: Regional analysis includes:

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Economic impact on Prenatal Genetic Testing industry and development trend of Prenatal Genetic Testing industry.

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Coronavirus threat to global Prenatal Genetic Testing Market 2020 Industry Share, Size, Consumption, Growth, Top Manufacturers, Type and Forecast to...

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A business intelligence report on theglobal Genetic Testing Services marketoffers quantitative estimation of the opportunities and qualitative assessment various growth dynamics. The study highlights estimations of the opportunities in the historical period, and offers several projections during the forecast period.

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The study on the Genetic Testing Services market includes detailed market estimations of opportunities in various segments and their share/size globally in each year during the forecast period. The following are the broad insights that form the backbone of the evaluation of the Genetic Testing Services market.

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Based on End-use Industry/Application,

Based on Product/Technology,

Based on Region,

Top players include

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Fact.MR is a fast-growing market research firm that offers the most comprehensive suite of syndicated and customized market research reports. We believe transformative intelligence can educate and inspire businesses to make smarter decisions. We know the limitations of the one-size-fits-all approach; thats why we publish multi-industry global, regional, and country-specific research reports.

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Genetic Testing Services Market to Witness Positive Growth owing to Outbreak of COVID-19, Projects Fact.MR - The Cloud Tribune

Recommendation and review posted by Bethany Smith

Global Animal Genetic Marketis expected to rise from its estimated value of USD 4.39 billion in 2018 to an estimated value of USD 8.68 billion by 2026 registering a CAGR of 8.9% in the forecast period of 2019-2026.The upcoming market report contains data for historic years 2017, the base year of calculation is 2018 and the forecast period is 2019 to 2026.Few of the major market competitors currently working in the animal genetics market areNEOGEN CORPORATION, Zoetis, Envigo, Animal Genetics Inc., VetGen, Groupe Grimaud, Hendrix Genetics BV, EW Nutrition GmbH, Alta Genetics Inc., Genus, Topigs Norsvin, CRV Holding B.V., URUS, Trans Ova Genetics., Inguran LLC dba STgenetics., Semex, Beacon Automation Pty Ltd., Cogent, EVOLUTION International , Genex Services, LLC, Rockway, Inc., River Valley Dairy., ABS GLOBAL, INC., Anicam Enterprises Inc., Milk Source. among others

Competitive Analysis: Global Animal Genetic Market

The global animal genetics market is highly fragmented and the major players have used various strategies such as new product launches, expansions, agreements, joint ventures, partnerships, acquisitions, and others to increase their footprints in this market. The report includes market shares of global animal genetics market for Global, Europe, North America, Asia Pacific, South America and Middle East & Africa.

Global Animal Genetic Market By Product (Live Animals (Poultry, Porcine, Bovines, Canine, Others), Genetic Material (Semens, Embroys)), Genetic Testing Services (DNA typing, genetic trait tests, genetic disease tests, and others), Geography (North America, South America, Europe, Asia-Pacific and Middle East and Africa) Industry Trends & Forecast to 2026;

Market Definition: Global Animal Genetic Market

Animal genetics is the branch of science which deals with the study of inheritance and gene variation in domestic and wild animals. Animal genetics are mostly used for genetic trait testing, DNA testing, and genetic disease traiting. The animal genetics market is expected to increase due to the fast demand, ingesting of animal proteins, and surge in urban population, which shows demand for meat products across the globe during the forecast period.

Market Drivers

Market Restraints

Segmentation: Global Animal Genetic Market

By Product

By Genetic Testing Services

Key Developments in the Market:

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Animal Genetic Market 2020 Industry Analysis and Detailed Profiles of Top Industry Players NEOGEN CORPORATION, Zoetis, Envigo, Animal Genetics Inc.,...

Recommendation and review posted by Bethany Smith

Genetic testing in men with prostate cancer can identify pathogenic variants early on that may inform proactive treatment, management of disease, and can be a resource in providing information about increased risks for other cancers for both the patient and their family members. Although the utility of genetic testing has been increasingly recognized for men with prostate cancer, determining which men to test has been an ongoing challenge. In 2017, expert consensus guidelines recommended genetic testing for men with at least one of the following.1

We analyzed 1,812 men with prostate cancer who underwent clinical genetic testing at a commercial genetic testing laboratory and performed stepwise logistic regression of the clinical variables reported on the test requisition forms to determine the most reliable predictors of positive results. Pathogenic variants were found in 12% of men who underwent multigene panel testing who had no prior genetic testing. This result was similar to comparable studies of the yield of multi-gene panel test results in men with prostate cancer.2,3Predictors of positive results included: increasing Gleason score, personal history of breast or pancreatic cancer, family history of breast, ovarian or pancreatic cancer, and family history of Lynch-syndrome associated cancers.

These results support the 2017 guidelines including testing men with aggressive disease or with a family history of cancers related to hereditary breast and ovarian cancer or Lynch syndrome. Similar to previous studies, we did not find an association between men who met the definition of hereditary prostate cancer and positive test results.1We were unable to confirm the association between mCRPC and positive results, as this clinical information was missing for 86.9% of the men in this cohort. However, other studies strongly support this association.2,4Likewise, prior somatic test results were not reported for most men in the study. It is unclear if somatic test results were not reported because most men did not have somatic testing, or if clinicians chose not to include this information on the test requisition form. Increasingly, clinicians will have somatic genetic results available for prostate cancer patients, as somatic testing is recommended for patients with mCRPC by the National Comprehensive Cancer Network guidelines. Somatic testing may identify pathogenic variants that require additional testing to determine if they are of germline origin, and typically providers will want to include somatic test results with the germline test requisition form so that the coverage of the exact alteration identified in the tumor can be confirmed in the germline.

We found that among all men with no prior genetic testing, the pooled frequency of pathogenic variants in therapeutically actionable genes at the time of the study (BRCA1/2 and mismatch repair genes) was 7.4%. Genetic testing is becoming increasingly relevant in this context considering the FDAs recent approval of olaparib and rucaparib for mCRPC patients with somatic and germline pathogenic variants in certain genes. Among men with prior genetic testing, 15% were found to have pathogenic variants via multi-gene panel testing that may have been missed based on previous test results (immunohistochemistry [IHC], limited germline testing). This included two men with normal IHC results who were found to have a pathogenic variant in a non-mismatch repair gene; one man who was found to have a mismatch repair mutation with discordant IHC results; and three men with previously limited germline testing who were found to have germline pathogenic variants upon expanded testing. These results highlight the importance of genetic testing and the utility of a multi-gene panel testing approach.

Written by:Mary Pritzlaff, MS, Reporting Genetic Counselor, CGC Ambry Genetics

References:

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Diagnosing Hereditary Cancer Predisposition in Men with Prostate Cancer - Beyond the Abstract - UroToday

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Study evaluates ovarian cancer risk detection in pre-menopausal womenPatients with and without genetic predisposition that are not planning surgery to be monitored with OVANex

AUSTIN, Texas, June 29, 2020 (GLOBE NEWSWIRE) -- Aspira Womens Health, Inc. (Nasdaq: AWH), a bioanalytical-based womens health company, today announced the first patient enrolled in a national clinical study of benign pelvic mass management. The study will enroll over 1,000 women for assessing ovarian cancer risk in women who have an adnexal mass and a high probability for developing the disease.

Many women who develop pelvic masses are hesitant to have surgery for a variety of reasons, clinical and personal, said Charles Dunton, MD, Global Medical Director, Aspira Womens Health (AWH). This study should confirm that this new multi-biomarker test can identify patients that are low risk and can wait to have surgery or perhaps avoid it entirely.

In this recently launched study, ovarian cancer risk will be assessed by a newly developed, multi-biomarker, proprietary algorithm based on AWHs experience and vast specimen bank in developing algorithms and FDA-cleared products for assessing ovarian cancer risk (OVA1 and OVERA). This study will enroll women in three distinct cohorts; women with pelvic masses without symptoms, women with pelvic masses with indeterminate symptoms, and women without pelvic masses that are high risk for ovarian cancer due to hereditary genetic risk. The primary objective is to determine which patients are low risk and can be monitored without surgery, and which women are at higher risk and need to be sent for further clinical assessment.

Today there are 1.2-1.5M women in the US with indeterminate pelvic masses which could be monitored. Providing a monitoring test where surgery is not clinically indicated, will help to reassure who is at low risk of developing ovarian cancer, and potentially who can safely wait for surgery or for their mass to resolve, said Valerie Palmieri, President, and CEO of AWH. Leveraging our proprietary technology with our over 10 years of expertise in Ovarian Cancer Risk assessment, has positioned us to develop this algorithm, and we are pleased to have launched this study. We are now one step closer in bringing this test to ALL women with pelvic masses.

About Aspira Womens Health Inc.ASPIRA Womens Health, Inc. (prior company name, Vermillion,Nasdaq:VRML) is transforming womens health with the discovery, development, and commercialization of innovative testing options and bio-analytical solutions that help physicians assess risk, optimize patient management and improve gynecologic health outcomes for women. ASPIRA is particularly focused on closing the ethnic disparity gap in ovarian cancer risk assessment and developing solutions for pelvic diseases such as pelvic mass risk assessment and endometriosis.OVA1plus includes our FDA-cleared products, OVA1and OVERAto detect risk of ovarian malignancy in women with adnexal masses. ASPIRA GenetiXTMtesting offers both targeted and comprehensive genetic testing options with a gynecologic focus. With over 10 years of expertise in ovarian cancer risk assessment, ASPIRA is delivering a portfolio of pelvic mass products over a patients lifetime with our cutting-edge research. The next generation of products in development are OVANEXTMand EndoCheckTM.Visit our website for more information at http://www.aspirawh.com.

Investor Relations Contact:Ashley R. RobinsonLifeSci Advisors, LLCTel 617-430-7577Arr@lifesciadvisors.com

Originally posted here:
Aspira Women's Health, Inc. Announces First Patient Enrolled in Prospective OVANex Study for Benign Pelvic Mass Monitoring - GlobeNewswire

Recommendation and review posted by Bethany Smith

Overview Of Oligonucleotides Industry 2020-2026:

The Oligonucleotides Market analysis summary by Reports Insights is a thorough study of the current trends leading to this vertical trend in various regions. Research summarizes important details related to market share, market size, applications, statistics and sales. In addition, this study emphasizes thorough competition analysis on market prospects, especially growth strategies that market experts claim.

Oligonucleotides are short nucleic acid polymers used in research, genetic testing and forensics.

Oligonucleotides are usually made up of 13 to 25 nucleotides and are designed to hybridize specifically to DNA or RNA sequences. Solid-phase clinical synthesis is used to manufacture these small bits of nucleic acid for use in polymerase chain reaction (PCR), DNA sequencing, library construction and artificial gene synthesis.

Oligonucleotide is widely used in Research, Pharmaceutical and Diagnostic. The most proportion of Oligonucleotide used in Research, and the revenue in 2018 is 409.97 M USD. Moreover, increase in focus on targeted gene therapies has revolutionized treatment of incurable conditions caused by genetic mutations. Increase in demand for sequencing applications by clinical, diagnostic, academic, and drug development is witnessed by manufactures.North America is the largest customer of Oligonucleotide, with a revenue market share nearly 37.51% in 2018. Europe is the second largest consumer of Oligonucleotide, enjoying revenue market share nearly 30.5% in 2018. Asian countries are recognized as the fastest adopters of sequencing, array technology, and PCR products due to rapid progress in genomics studies and the healthcare sector. Japan and China are considered as the most attractive markets with respect to expansion and growth opportunities present in these countries. In addition, changing economic scenario, along with high investments in healthcare, life science-related research programs, and genetics, has encouraged global players to enter the Asia Pacific market, thus aiding its growth.

Oligonucleotides Market competition by top manufacturers as follow: , Integrated DNA Technologies, Agilent, Sigma-aldrich, Eurofins Genomics, L.G.C Biosearch Technologies, Eurogentec S.A, Nitto Denko Avecia Inc, GenScript, BBI Life Sciences, GeneDesign, TriLink BioTechnologies, SGS DNA, LC Sciences, Twist Bioscience, Creative Biogene, General Biosystems

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This has brought along several changes in This report also covers the impact of COVID-19 on the global market.

The global Oligonucleotides market has been segmented on the basis of technology, product type, application, distribution channel, end-user, and industry vertical, along with the geography, delivering valuable insights.

The Type Coverage in the Market are: DNA OligosRNA Oligos

Market Segment by Applications, covers:PharmaceuticalResearchDiagnostic

Market segment by Regions/Countries, this report coversNorth AmericaEuropeChinaRest of Asia PacificCentral & South AmericaMiddle East & Africa

Major factors covered in the report:

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COVID-19 Impact: Oligonucleotides Market | Strategic Industry Evolutionary Analysis Focus on Leading Key Players and Revenue Growth Analysis by...

Recommendation and review posted by Bethany Smith

This report will definitely help you make well informed decisions related to the stem cell market. The stem cell therapy market includes large number of players that are involved in development of stem cell therapies of the treatment of various diseases. Mesoblast Ltd. (Australia), Aastrom Biosciences, Inc. (U.S.), Celgene Corporation (U.S.), and StemCells, Inc. (U.S.) are the key players involved in the development of stem cell therapies across the globe.

The global stem cells market is expected to grow at an incredible CAGR of 25.5% from 2018to 2024and reach a market value of US$ 586 billion by 2025. The emergence of Induced Pluripotent Stem (iPS) cells as an alternative to ESCs (embryonic stem cells), growth of developing markets, and evolution of new stem cell therapies represent promising growth opportunities for leading players in this sector.

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Due to the increased funding from Government and Private sector and rising global awareness about stem cell therapies and research are the main factors which are driving this market. A surge in therapeutic research activities funded by governments across the world has immensely propelled the global stem cells market. However, the high cost of stem cell treatment and stringent government regulations against the harvesting of stem cells are expected to restrain the growth of the global stem cells market.

The stem cell therapy market includes large number of players that are involved in development of stem cell therapies of the treatment of various diseases. Mesoblast Ltd. (Australia), Aastrom Biosciences, Inc. (U.S.), Celgene Corporation (U.S.), and StemCells, Inc. (U.S.) are the key players involved in the development of stem cell therapies across the globe.

This market research report categorizes the stem cell therapy market into the following segments and sub-segments:

The Global Stem Cell Market this market is segmented on the basis of Mode of Therapy, Therapeutic Applications and Geography.

By Mode of Therapy this market is segmented on the basis of Allogeneic Stem Cell Therapy Market and Autologous Stem Cell Therapy Market. Allogeneic Stem Cell Therapy Market this market is segmented on the basis of CVS Diseases, CNS Diseases, GIT diseases, Eye Diseases, Musculoskeletal Disorders, Metabolic Diseases, Immune System Diseases, Wounds and Injuries and Others. Autologous Stem Cell Therapy Market this market is segmented on the basis of GIT Diseases, Musculoskeletal Disorders, CVS Diseases, CNS Diseases, Wounds and Injuries and Others. By Therapeutic Applications this market is segmented on the basis of Musculoskeletal Disorders, Metabolic Diseases, Immune System Diseases, GIT Diseases, Eye Diseases, CVS Diseases, CNS Diseases, Wounds and Injuries and Others.

By Regional Analysis this market is segmented on the basis of North America, Europe, Asia-Pacific and Rest of the World.

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Table of Contents

1 INTRODUCTION

2 Research Methodology

2.1 Research Data2.1.1 Secondary Data2.1.1.1 Key Data From Secondary Sources2.1.2 Primary Data2.1.2.1 Key Data From Primary Sources2.1.2.2 Breakdown of Primaries2.2 Market Size Estimation2.2.1 Bottom-Up Approach2.2.2 Top-Down Approach2.3 Market Breakdown and Data Triangulation2.4 Research Assumptions

3 Executive Summary

4 Premium Insights

5 Market Overview

6 Industry Insights

7 Global Stem Cell Therapy Market, By Type

8 Global Stem Cell Therapy Market, By Therapeutic Application

9 Global Stem Cell Therapy Market, By Cell Source

10 Stem Cell Therapy Market, By Region

11 Competitive Landscape

12 Company Profiles

12.1 Introduction

12.1.1 Geographic Benchmarking

12.2 Osiris Therapeutics, Inc.

12.3 Medipost Co., Ltd.

12.4 Anterogen Co., Ltd.

12.5 Pharmicell Co., Ltd.

12.6 Holostem Terapie Avanzate Srl

12.7 JCR Pharmaceuticals Co., Ltd.

12.8 Nuvasive, Inc.

12.9 RTI Surgical, Inc.

12.10 Allosource

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Global Stem Cells Market 2019 | How The Industry Will Witness Substantial Growth In The Upcoming Years | Exclusive Report By MRE - Cole of Duty

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Scope of the Report

The report titled Global Regenerative Medicine Market: Size & Forecast with Impact Analysis of COVID-19 (2020-2024), provides an in-depth analysis of the global regenerative medicine market with description of market sizing and growth. The analysis includes market by value, by product, by material and by region. Furthermore, the report also provides detailed product analysis, material analysis and regional analysis.

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Moreover, the report also assesses the key opportunities in the market and outlines the factors that are and would be driving the growth of the industry. Growth of the overall global regenerative medicine market has also been forecasted for the years 2020-2024, taking into consideration the previous growth patterns, the growth drivers and the current and future trends.

Some of the major players operating in the global regenerative medicine market are Novartis AG, Medtronic Plc, Bristol Myers Squibb (Celgene Corporation) and Smith+Nephew (Osiris Therapeutics, Inc.), whose company profiling has been done in the report. Furthermore, in this segment of the report, business overview, financial overview and business strategies of the respective companies are also provided.

Region Coverage

North AmericaEuropeAsia PacificROW

Company Coverage

Novartis AGMedtronic PlcBristol Myers Squibb (Celgene Corporation)Smith+Nephew (Osiris Therapeutics, Inc.)

Executive Summary

Regenerative medicines emphasis on regeneration or replacement of tissues, cells or organs of human body to cure the problem caused by disease or injury. The treatment fortify human cells to heal up or transplant stem cells into the body to regenerate lost tissues or organs or to recover impaired functionality. There are three types of stem cells that can be used in regenerative medicine: somatic stem cells, embryonic stem cells (ES cells) and induced pluripotent stem cells (iPS cells).

The regenerative medicine also has the capability to treat chronic diseases and conditions, including Alzheimers, diabetes, Parkinsons, heart disease, osteoporosis, renal failure, spinal cord injuries, etc. Regenerative medicines can be bifurcated into different product type i.e., cell therapy, tissue engineering, gene therapy and small molecules and biologics. In addition, on the basis of material regenerative medicine can be segmented into biologically derived material, synthetic material, genetically engineered materials and pharmaceuticals.

The global regenerative medicine market has surged at a progressive rate over the years and the market is further anticipated to augment during the forecasted years 2020 to 2024. The market would propel owing to numerous growth drivers like growth in geriatric population, rising global healthcare expenditure, increasing diabetic population, escalating number of cancer patients, rising prevalence of cardiovascular disease and surging obese population.

Though, the market faces some challenges which are hindering the growth of the market. Some of the major challenges faced by the industry are: legal obligation and high cost of treatment. Whereas, the market growth would be further supported by various market trends like three dimensional bioprinting , artificial intelligence to advance regenerative medicine, etc.

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Table of Contents

1. Executive Summary

2. Introduction

2.1 Regenerative Medicine: An Overview2.2 Regeneration in Humans: An Overview2.3 Expansion in Peripheral Industries of Regenerative Medicine2.4 Approval System for Regenerative Medicine Products2.5 Regenerative Medicine Segmentation

3. Global Market Analysis

3.1 Global Regenerative Medicine Market: An Analysis

3.1.1 Global Regenerative Medicine Market by Value3.1.2 Global Regenerative Medicine Market by Products (Cell Therapy, Tissue Engineering, Gene Therapy and Small Molecules and Biologics)3.1.3 Global Regenerative Medicine Market by Material (Biologically Derived Material, Synthetic Material, Genetically Engineered Materials and Pharmaceuticals)3.1.4 Global Regenerative Medicine Market by Region (North America, Europe, Asia Pacific and ROW)

3.2 Global Regenerative Medicine Market: Product Analysis

3.2.1 Global Cell Therapy Regenerative Medicine Market by Value3.2.2 Global Tissue Engineering Regenerative Medicine Market by Value3.2.3 Global Gene Therapy Regenerative Medicine Market by Value3.2.4 Global Small Molecules and Biologics Regenerative Medicine Market by Value

3.3 Global Regenerative Medicine Market: Material Analysis

3.3.1 Global Biologically Derived Material Market by Value3.3.2 Global Synthetic Material Market by Value3.3.3 Global Genetically Engineered Materials Market by Value3.3.4 Global Regenerative Medicine Pharmaceuticals Market by Value

4. Regional Market Analysis

4.1 North America Regenerative Medicine Market: An Analysis4.1.1 North America Regenerative Medicine Market by Value

4.2 Europe Regenerative Medicine Market: An Analysis4.2.1 Europe Regenerative Medicine Market by Value

4.3 Asia Pacific Regenerative Medicine Market: An Analysis4.3.1 Asia Pacific Regenerative Medicine Market by Value

4.4 ROW Regenerative Medicine Market: An Analysis4.4.1 ROW Regenerative Medicine Market by Value

5. COVID-19

5.1 Impact of Covid-195.2 Response of Industry to Covid-195.3 Variation in Organic Traffic5.4 Regional Impact of COVID-19

6. Market Dynamics

6.1 Growth Drivers6.1.1 Growth in Geriatric Population6.1.2 Rising Global Healthcare Expenditure6.1.3 Increasing Diabetic Population6.1.4 Escalating Number of Cancer Patients6.1.5 Rising Prevalence of Cardiovascular Disease6.1.6 Surging Obese Population

6.2 Challenges6.2.1 Legal Obligation6.2.2 High Cost of Treatment

6.3 Market Trends6.3.1 3D Bio-Printing6.3.2 Artificial Intelligence to Advance Regenerative Medicine

7. Competitive Landscape

7.1 Global Regenerative Medicine Market Players: A Financial Comparison7.2 Global Regenerative Medicine Market Players by Research & Development Expenditure

8. Company Profiles

8.1 Bristol Myers Squibb (Celgene Corporation)8.1.1 Business Overview8.1.2 Financial Overview8.1.3 Business Strategy

8.2 Medtronic Plc8.2.1 Business Overview8.2.2 Financial Overview8.2.3 Business Strategy

8.3 Smith+Nephew (Osiris Therapeutics, Inc.)8.3.1 Business Overview8.3.2 Financial Overview8.3.3 Business Strategy

8.4 Novartis AG8.4.1 Business Overview8.4.2 Financial Overview8.4.3 Business Strategy

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Global Regenerative Medicine Market: Size and Forecast with Impact Analysis of COVID-19 (2020-2024) - Cole of Duty

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Introduction

Breastfeeding is the cornerstone of infant and young child survival, nutrition and development and maternal health. The World Health Organization recommends exclusive breastfeeding for the first 6 months of life, followed by continued breastfeeding with appropriate complementary foods for up to 2 years and beyond.1 Early and uninterrupted skin-to-skin contact, rooming-in2 and kangaroo mother care3 also significantly improve neonatal survival and reduce morbidity and are recommended by WHO.

However, concerns have been raised about whether mothers with COVID-19 can transmit the SARS-CoV-2 virus to their infant or young child through breastfeeding. Recommendations on mother-infant contact and breastfeeding must be based on a full consideration of not only of the potential risks of COVID-19 infection of the infant, but also the risks of morbidity and mortality associated with not breastfeeding, the inappropriate use of infant formula milks, as well as the protective effects of skin-to-skin contact. This scientific brief examines the evidence to date on the risks of transmission of COVID-19 from an infected mother to her baby through breastfeeding as well as evidence on the risks to child health from not breastfeeding.

WHO recommends that mothers with suspected or confirmed COVID-19 should be encouraged to initiate or continue to breastfeed. Mothers should be counselled that the benefits of breastfeeding substantially outweigh the potential risks for transmission.4

Mother and infant should be enabled to remain together while rooming-in throughout the day and night and to practice skin-to-skin contact, including kangaroo mother care, especially immediately after birth and during establishment of breastfeeding, whether they or their infants have suspected or confirmed COVID-19.

A living systematic review of evidence that followed the procedures of the Cochrane handbook for systematic reviews of interventions was carried out with the latest search done on 15 May 2020 to identify studies including mothers with suspected or confirmed COVID-19 and their infants or young children.5 The search was conducted on Cochrane Library, EMBASE (OVID), PubMed (MEDLINE), Web of Science Core Collection (Clarivate Analytics) and the WHO Global Database. A total of 12,198 records were retrieved, 6945 were screened after removing duplicates, and 153 records with mother-infant dyads in which the mother had COVID-19 were included in full-text review.

A total of 46 mother-infant dyads had breastmilk samples tested for COVID-19. All mothers had COVID-19, while 13 infants tested COVID-19 positive. Breastmilk samples from 43 mothers were negative for the COVID-19 virus while samples from 3 mothers tested positive for viral particles by RT-PCR. Among the 3 infants whose mothers breastmilk tested positive for virual RNA particles, not live virus, one infant tested positive for COVID-19 but infant feeding practices were not reported. The two other infants tested negative for COVID-19; one was breastfed, and the other newborn was fed expressed breast milk after viral RNA particles were no longer detected. In the single child with COVID-19, it was unclear through which route or source the infant became infected, i.e. through breastmilk or droplet from a close contact with the infected mother.

A preprint article reported secretory immunoglobulin A (sIgA) immune response against the COVID-19 virus found in 12 of 15 breastmilk samples from mothers with COVID-19.6 The implications of this finding on the effect, duration and protection against COVID-19 for the child was not addressed.

To date, studies of mother-infant dyads with data on feeding practices and COVID-19 infection have come from case reports, case series or a report of a family cluster. Other study designs such as cohort studies or case-control studies were eligible for inclusion, but none were identified. We are thus unable to measure and compare risks of infection based on feeding practices.

Although 1 of the 3 infants of mothers with viral particles in breast milk had COVID-19, it was unclear through which route or source the infant was infected, i.e., through breastfeeding or close contact with the mother or other infected person. RT-PCR detects and amplifies viral genetic material in samples, such as breastmilk, but does not provide information on viability or infectivity of the virus. Documented presence of replicative COVID-19 virus in cell culture from breast milk and infectivity in animal models are needed to consider breast milk as potentially infectious.

The presence of IgA in breast milk is one of the ways in which breastfeeding protects infants against infection and death. IgA antibodies with reactivity to the COVID-19 virus have been detected in breastmilk of mothers previously infected with COVID-19 but their strength and durability have not yet been adequately studied to address protection from COVID-19 among breastfed infants.

Detection of COVID-19 viral RNA in breastmilk is not the same as finding viable and infective virus. Transmission of COVID-19 would need replicative and infectious virus being able to reach target sites in the infant and also to overcome infant defense systems. If in the future COVID-19 virus from breastmilk were shown to be replicative in cell culture it would need to reach target sites in the infant and overcome infant defense systems for transmission of COVID-19 to occur.

The implications of transmission risk need to be framed in terms of COVID-19 prevalence in breastfeeding mothers and the scope and severity of COVID-19 infection in infants when transmission occurs compared to the adverse consequences of separation and using breastmilk substitutes and also separation of newborns and young infants from mothers.

Children appear to be at low risk of COVID-19. Among the cases of confirmed COVID-19 in children, most have experienced only mild or asymptomatic illness.7,8 This is also the case with other zoonotic coronaviruses (SARS-CoV and MERS-CoV), which seem to affect children less commonly and to cause fewer symptoms and less severe disease compared with adults.9

Secretory IgA have been detected in breastmilk of mothers with previous COVID-19 infection. Although the strength and durability of sIgA reactive to COVID-19 have not yet been determined, multiple bioactive components have been identified in breastmilk that not only protect against infections but improve neurocognitive and immunologic development of the child since Lars A Hanson first described sIgA in breastmilk in 1961.10-12

Skin-to-skin contact and kangaroo mother care facilitate breastfeeding as well as improve thermoregulation, blood glucose control, and maternal-infant attachment, and decrease the risk in mortality and severe infection among low birth weight infants.13,14 Beyond the neonatal period, positive effects of mother-infant holding include improved sleep patterns, lower rates of behavioural problems in the child and higher quality parental interaction.15,16

Exclusively breastfed infants, the risk of mortality is 14-fold higher in infants who are not breastfed.17 Over 820 000 childrens lives could be saved every year among children under 5 years, if all children 0-23 months were optimally breastfed. For mothers, breastfeeding protects against breast cancer and may protect against ovarian cancer and type 2 diabetes.18 On the other hand, children are at low risk of COVID-19.

It is still not clear whether the virus can or cannot be transmitted though breast milk. Risk of transmission based on feeding practices have not been quantified, compared, or modelled against the benefits of breastfeeding and nurturing mother-infant interaction.

At present, data are not sufficient to conclude vertical transmission of COVID-19 through breastfeeding. In infants, the risk of COVID-19 infection is low, the infection is typically mild or asymptomatic, while the consequences of not breastfeeding and separation between mother and child can be significant. At this point it appears that COVID-19 in infants and children represents a much lower threat to survival and health than other infections that breastfeeding is protective against. The benefits of breastfeeding and nurturing mother-infant interaction to prevent infection and promote health and development are especially important when health and other community services are themselves disrupted or limited. Adherence to infection prevention and control measures is essential to prevent contact transmission between COVID-19 suspected or confirmed mothers and their newborns and young infants.

Based on available evidence, WHO recommendations on the initiation and continued breastfeeding of infants and young children also apply to mothers with suspected or confirmed COVID-19.

WHO continues to monitor the situation closely for any changes that may affect this interim guidance. Should any factors change, WHO will issue a further update. Otherwise, this scientific brief will expire 2 years after the date of publication.

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Breastfeeding and COVID-19 - World Health Organization

Recommendation and review posted by Bethany Smith

Starbucks will be a part of the rising listing of company entities pausing promoting on social media platforms, the corporate said in a blog post Sunday. The espresso big says that it stands in opposition to hate speech and believes each enterprise leaders and coverage makers want to return collectively to have an effect on actual change.

We are going to pause promoting on all social media platforms whereas we proceed discussions internally, with our media companions and with civil rights organizations within the effort to cease the unfold of hate speech, the weblog submit, titled Creating Welcoming and Inclusive On-line Communities states.

A Starbucks spokesperson informed The Verge Sunday that the corporates social media promoting pause wont embrace YouTube, and whereas Starbucks will proceed to submit to social media, it gainedt do paid promotions.

Starbucks additionally will not be formally becoming a member of the Stop Hate For Profit campaign organized by the Anti-Defamation League, the NAACP, and different social justice organizations. The marketing campaign is aimed particularly at Fb and its moderation insurance policies round violent threats, misinformation, and hate speech, and requires a boycott of promoting on the platform for the month of July. Unilever, Verizon, the North Face, Patagonia, Ben & Jerrys, Magnolia Photos, Honda, and Hershey have all signed on to the Cease Hate for Revenue marketing campaign.

The Coca-Cola Firm went a step additional and introduced Friday it was pausing all digital promoting on all social media platforms globally starting July 1st. Multinational beverage firm Diageo made a similar pledge.

Fb CEO Mark Zuckerberg introduced a collection of modifications final week which werent immediately in response to the advertiser boycott, however tackle a few of the criticisms of the corporates insurance policies. Fb stands for giving individuals a voice, and that particularly means individuals who have beforehand not had as a lot voice, or as a lot energy to share their very own experiences, Zuckerberg stated in a company town hall. Its actually essential that we be sure that our platforms dwell as much as these rules.

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Top 10 Best Cream Serum With Vitamin Es 2020 - Best gaming pro

Recommendation and review posted by Bethany Smith

There are so many skincare brands on the market today, their number may flood your social media feed that it may be difficult to choose the right one for you this summertime. Sensitive skin, aging, tired skin, fair, dark, or a combination, its particularly rare for a single product or brand that can nourish and protect you during this season. However, by using a variety of brands that suit you, you may achieve that glowing healthy skin youve always wanted.

Here is a list of 8 products and options that can help you obtain the perfect skin this summer:

This brand is inspired and designed by leading cosmeceutical scientists for skincare, anti-aging, removal of blemish, and other skin issues. Their products are clinically tested, which makes SkinPro represent the industrys advanced skincare technology. Its perfect for enjoying the sun during the day and experience the rejuvenating effects with strengthened efficacy while being sensitive to the skin. The formulations are made by proprietary technology to give you a special combination of active ingredients that will remedy skin problems and provide lasting results.

Pair your tan with skincare that keeps your skins aging process to a minimum while enjoying the sun. You can use the Nimni Day Cream to protect and smoothen your skin with special collagen boosting complex infused with environmental shields. Summer-soft touchable skin is truly achievable while preventing possible daytime sun damage. When the sun sets and before going to bed to close another day, use the Nimni Night Cream and take some time to yourself.

Caudalie is a French skincare brand, based on all-natural grape extracts from the Bordeaux, Champagne, and Burgundy regions. Red wine drinkers already know this to be true: grapes are high in antioxidants and resveratrol compounds and polyphenols which give the whole line its unique and successful philosophy of anti-aging.

The whole line of SK-II revolves on a special ingredient called Pitera. History has it that workers who were subjected to a fermentation substance at a Japanese factory have remarkably ageless and spotless palms. In a slew of anti-aging creams, serums, masks, and most famously a skin-brightening facial treatment essence the secret sauce was packaged up and shipped.

It is one of those skincare brands that you can apply by yourself or as an aftercare treatment based on your preferences and goals. CosmetiCare has everything you need to fix anti-aging, acne, or pigmentation so you can get a sun-radiant, healthy, vibrant complexion. Using their Amplify-Hyaluronic Acid Enhancing Serum to lighten your dry skin with moisture when strengthening the skins lipid barrier. It is especially good for your summer skin, which requires the extra boost from day to day activities to keep your skin moisturized.

Think of skincare product creativity! If youre hunting for skincare brands with coveted distinctions to be the best-selling brands, then youll meet Factor Five Skin here. With this best-selling serum, take your regimen to a whole new dimension that dares to deviate from conventional anti-aging products. Their Regenerative Serum works on wrinkles, sun spots, uneven texture, and more. Combining human stem cell growth factors with copper peptides will make your skin look renewed and restored in as little as 4 weeks!

Your time in the sun is not supposed to reveal the years of skin life. This youth-infusing bundle of skin-loving ingredients is nicely packaged in the Mature Skin Anti-Aging Kit to help you reverse or prevent premature aging. Turn back the time or stand still with this scientifically crafted and evidence-based ingredient combination. Prepare to erase the fine lines, wrinkles, and discolorations of the skin, and shrink large pores with this impressive collection of anti-aging skincare:

This summer, when you apply the Mature Skin Anti-Aging Kit to your regimen, your sun-kissed lips, eyes, and dcolletage region will be completely plumped up and beautifully radiant. Cap off the week with the Hydroxy Overnight Mask, an exfoliating and hydrating leave-on-night mask composed of salicylic acids.

If you tend to have skin that is prone to acne, oily, sun-damaged, or sensitive, then you will want to use this product a few times a week. The Aloe Veras soothing compounds help soothe drained, old skin cells when youre asleep! You can use it as a mask or even best as a spot-treatment for rare breakouts, and youd wake to clean and healthy skin.

Who wouldnt love skincare brands that make an utter joy in washing your face? Only the word Kale Cleanser makes you want to make every morning and evening a spa day in your house! Its a concentrated combination of superfoods and antioxidants that hydrate your skin while reducing oxidative damage to the blue light. Its so sweet, you should probably use it twice a day and wash the dirt and extra grime of the day away. Follow it up next with the Moisturizer Adaptogens Superfruits.

This yummy moisturizer feeds some of the most powerful anti-aging ingredients to amplify the natural development of collagen in your skin while helping to prevent free-radical damage. Then what better way to soothe your exposed skin during the summer than with the Adaptogens Superfruits Mask. The sun may be bright, but if it is not revitalized, it can quickly dull your skin. Its creamy, smooth, and not only smells great, but after just one try, it leaves your skin smooth and rejuvenated. Piper Berry is one of the skincare brands that we love for quick fixing and refreshing the skin anytime, anywhere.

With these products, youll be summer-ready to enjoy activities that you can only do when the suns out while protecting and nourishing your skin. If you have sensitive skin make sure to apply only a small amount and gradually increase when you dont show any signs of negative reaction. Investing in the protection and rejuvenation of your skin will surely hold off father time from getting his hands on your glowing face.

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Skincare Brands To Try Out This Summer - GirlTalkHQ

Recommendation and review posted by Bethany Smith