The oldest members of the millennial generation are now 38 years old, according to Pew Research Center's definition.

That means many of them will soon be experiencing menopause, or the end of a woman's reproductive period. Menopause typically occurs between the ages of 45 and 55, according to the National Institute on Aging.

Menopause is often considered a taboo topic because of our youth-worshipping culture, and medical students aren't always educated on the condition and how to help patients who have it, according to Dr. Mary Jane Minkin, a gynecologist and professor at Yale University.

To break down the stigma, Minkin said patients should ask for more menopause information.

Here are some things about delaying menopause and handling symptoms you should know right off the bat.

Genetics, cancer therapies, and whether you've had a hysterectomy all play a role in when you'll go into menopause since these factors affect your hormone levels.

Your weight and cigarette-smoking habit could play a role in when you get menopause, according to a Minkin. If a person were to stop smoking or lose weight (if they're overweight), it could delay menopause onset one to two years.

Read more: 8 answers to common questions about ovulation you've been too afraid to ask

In the months and years leading up to menopause, a woman might experience irregular periods, hot flashes, vaginal dryness, sleep disturbances, and mood swings, according to The North American Menopause Society. It's all caused by hormone fluctuations during this time, called perimenopause.

These issues can persist for many years after menopause, Minkin said. But there are ways to decrease symptoms, including lifestyle changes and medications.

In addition to potentially bringing on menopause sooner than usual, smoking can also make symptoms worse.

"Smokers have much worse hot flashes than non-smokers, so if you stop smoking, not only is it good for you, but also your hot flashes," Minkin said. The same goes for weight loss in overweight people.

Hormone therapy uses progestin and estrogen to help decrease symptoms like hot flashes, but is underused because of the Women's Health Initiative, a National Institutes of Health-funded group of studies published in 2002. The report said estrogen therapy could increase a woman's breast cancer risk and scared many people away from hormone therapy.

The 2002 report has since been debunked and hormone therapy is now recognized as a safe treatment for menopause symptoms, especially hot flashes.

"Unfortunately, the bad press about estrogen has persisted for a number of years, but now we're getting better," Minkin said. "Estrogen really can be your friend."

Other medications used off-label, like the seizure medication gabapentin and the high blood pressure medication clonidine, may also help prevent or lessen hot flashes, according to the Mayo Clinic.

If you have these symptoms and want treatment, discuss options with your healthcare provider.

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How to treat hot flashes, vaginal dryness, other menopause symptoms - INSIDER

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(Photo : Photo by Ahmed Carter )

Polycystic ovary syndrome (PCOS) is a condition that affects about 4% to 10% of women. Both men and women produce androgen type hormones but men usually produce more androgens and women normally produce more estrogens. However, in some cases, women may produce too many androgen hormones, so that their testosterone levels are higher than normal.

The problem with PCOS is that it actually leads to alopecia like that seen in men. This means that there is often hair lost from the head in a similar fashion to that seen in men with androgenetic alopecia. The hormonal disruptions and increased androgen production that is seen in women with PCOS has also been linked to the development of other problems such as insulin resistance and increased inflammation in the body.

The hyperandrogenism actually impacts the hair follicles causing the thinning and loss of hair on the scalp. Although women with PCOS show male pattern hair loss on their scalp, elsewhere they grow excess body hair. They also tend to have more acne breakouts than other women and often gain too much weight.

PCOS is a condition that a woman should seek treatment for because it causes so many problems, and can even cause infertility and increases the risks of getting endometrial cancer. Treatment options vary but almost all doctors recommend changes in lifestyle such as increasing the amount of exercise and eating healthy, nutritious foods.

Besides lifestyle changes, birth control can be prescribed to help regulate hormone levels and to increase and control the levels of the female sex hormones, estrogen and progesterone. Women who have PCOS and who are trying to get pregnant are often put on fertility drugs since the condition frequently lowers fertility making pregnancy difficult.

The hair loss can be treated in a variety of ways including by getting hair transplant surgery. There are some medications as well that may be helpful for your hair, such as spironolactone, minoxidil and finasteride. The problem is that there are often unpleasant and unwanted side effects associated with taking these medications. They also may be a problem if you plan on becoming pregnant. You can read more about hair loss treatment options if you have PCOS by visiting the Vera Clinic.

There are other options for treating hair loss problems caused by PCOS. Some women may opt for laser light treatment or even plasma-rich platelet therapy. The PRP does offer a good option since it is autologous, meaning it uses your own blood supply so there is no risk of tissue rejection because of your body's immune system. PRP does help to stimulate the growth of your skin and hair follicles and can produce good results.

Another possibility for women who have lost hair due to PCOS is to have a hair transplant procedure such as Follicular Unit Extraction (FUE). This is a popular type of hair transplant procedure that is commonly used to treat alopecia in men and women. The results can be very good, but it does take time for the hair to grow in.

Excerpt from:
How PCOS Can Cause Hair Loss - Youth Health Magzine

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Global Thyroid Hormone Disorder Drug Market 2019 by Manufacturers, Regions, Type and Application, Forecast to 2024 is a powerful tool that market participants can use to secure a strong position in the global Thyroid Hormone Disorder Drug market. The report studies the market status and growth opportunities from different outlooks such as from the key players angle, topographical regions, and type and application segments. The report sheds light on the market segmentation, market dynamics, the competitive landscape, manufacturing cost structure, marketing channels, and regional growth. It offers critical elements of a combined database of even supply-demand ratio. A SWOT analysis was used to bring out power, weaknesses, opportunities, and risks of the leading vendors. The research study is a great combination of both statistically relevant quantitative data of the industry and insightful qualitative comment and analysis

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Global Thyroid Hormone Disorder Drug Market Research and Forecast, 2019-2024 - News Coed

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Brain research has shown how relevant sleep is to health, so it's more important than ever to get a good night's sleep. In the bedroom, that means not just decorating in calming colors but also minimizing stressors and optimizing conditions for a restful night. We asked some experts for advice and products to achieve that.

Minimize noise

A key obstacle to uninterrupted sleep is noise. To reduce it, Brooklyn-based architect and designer Adam Meshberg, founder of Meshberg Group, recommends soundproofing the walls building an additional thin wall in front of the original, adding a layer of QuietRock sheetrock, or sealing any cracks or gaps within the walls. To a lesser extent, wallcoverings can also absorb sound, he says, though a padded wallcovering will do more than a simple wallpaper.

Cracks and gaps are also a problem when it comes to windows. Restoring or replacing drafty windows won't just improve your heating and cooling bills; doing so can make a huge difference in the amount of noise seeping in. If renovation isn't an option, some companies will install a thin window behind your existing window for extra soundproofing. CitiQuiet in New York says it can eliminate 95 percent of street noise.

For a simpler fix, getting an upholstered headboard (or a bed that comes with one) helps with acoustics, says Florida-based designer Adriana Hoyos. Go for fabrics at least one millimeter thick; suede, velvet, leather and leatherette are stylish options for absorbing excess noise.

Andrew Bowen, director of staging at ASH NYC, suggests a combination of loose items a large area rug (he likes the Rug Company's Deep Pile Merino Natural Rug, $137 per square foot), floor-to-ceiling window drapery and a fully upholstered bed (he recommends Cisco Brothers' April Modern Classic White Linen Slipcovered Bed, $2,375-$3,000 at Kathy Kuo Home) for a quiet, relaxing environment.

Alternatively, try white noise. A fan might do the trick, but Julien Baeza, assistant project manager at Four Seasons Hotel Los Angeles, suggests Spotify and soundscape machines.

Keep the lights out

Lights out is essential to bedtime. In particular, avoid exposure to the blue light from LED bulbs and electronic devices, says Pablo Castillo, sleep medicine specialist at Mayo Clinic. "The body reacts to this artificial light as if it [were] still daytime," he said in an email, "and the pineal gland will stop producing the sleep hormone melatonin, resulting in poor sleep quality."

That's why you should stay away from bright light for at least three hours before bedtime, reduce screen time, and set devices on night mode an hour or two before bed, plus use blue-light-blocking coating on screens or glasses if you "use computers and digital devices heavily," Castillo wrote.

To lightproof the bedroom, "blackout window treatments are a must," said Greg Roth, a designer at Home Front Build in Los Angeles, by email. "Installing a cornice box at the ceiling level can help prevent light from escaping upward from the windows and reflecting off the ceiling." Meshberg recommends the Shade Store and Somfy for motorized shades.

Go soft and simple

Simplify your space for sleeping only. It doesn't matter whether you live in a mansion or a studio, you can declutter for a calming effect, according to Meridith Baer, founder of staging company Meridith Baer Home.

A sleep-friendly bedroom is like a "good snuggle" one that makes you "feel embraced and safe," like a cocoon, Alex P. White, a furniture designer and decorator based in New York and Los Angeles, said in an email. So keep things "tonal and tactile with as many luxurious materials as your budget allows."

As for decor, keep things light and uncomplicated, says New York designer Ryan Korban. He recommends using light-colored paints that are warm and not stark (he likes Lily White from Benjamin Moore) and light-wood floors.

For the most soothing tone, Leatrice Eiseman, executive director of the Pantone Color Institute, recommends sky blue, writing in an email that it's a "positive color" with a sense of "dependability" that can help you fall asleep. You can create a "blue sky" by painting the ceiling, Eiseman suggests. Make it high-gloss for more definition.

Regulate your schedule

Not everyone needs eight hours of sleep, but to "avoid chaos in your circadian rhythms, it is suggested that you maintain the same schedule every day," says Rachel Salas, sleep specialist and associate professor of neurology at Johns Hopkins Medicine.

"Lights in the bedroom should be dimmable or have the ability to adjust to a low setting," Meshberg says. They can help your brain transition to slumber mode. Go for bedside sconces or lamps (he likes the Pennant Wall Lamp by Andrew Neyer, $200-$300 at Y Lighting, and the Convessi Sconce, $495 at Restoration Hardware).

For frequent travelers and those working night shifts, a circadian lighting system, which adjusts from a warm color spectrum to a cooler spectrum and back to mimic natural light cycles, can be especially useful. Such systems can "artificially create an ambiance that minimizes jet lag and allows for deep sleep," Baeza wrote in an email. "Some sophisticated LED systems allow for automatic dimming and color changes over time."

The brand Ketra sells lighting fixtures, bulbs and controls that can create such natural lighting and integrate with home automation systems.

Focus on the bed

No doubt, the most important component is the bed. That's why selecting the right mattress, sheets and pillows can help you get a good slumber. Meshberg recommends 200- to 300-thread-count organic cotton sheets such as the Classic Starter Sheet Set (starting at $93, Brooklinen) and the Italian Vintage-Washed 464 Percale Sheet Set ($369-$429, Restoration Hardware). They "breathe well" and don't get "too satiny and shiny" like sheets with higher thread counts.

Also, "the quality and proper weight of your duvet and down comforter are essential in regulating your temperature," Meshberg wrote. Generally, 700-fill comforters are best for winter and 600-fill works well during summer. (Fill refers to down; synthetics might be labeled as heavyweight or lightweight.) He recommends the down comforters from Brooklinen ($199-$299) and the Organic Italian Vintage-Washed 464 Percale Duvet ($389-$449) from Restoration Hardware. (The National Sleep Foundation also recommends setting your thermostat at 60 to 67 degrees.)

For a mattress, he suggests Casper's Original ($595-$1,195) or Wave ($1,345-$2,495) for those who prefer more support. The Beautyrest Recharge Dawson 12-inch hybrid firm mattress ($1,299-$1,999, mattressfirm.com) works well for those sharing beds with restless sleepers because the memory foam won't move around as much, Meshberg says.

As for pillows, "synthetic is the best" because you can wash it, he says.

Read more:
Cant sleep? You probably need to make these changes. - The Providence Journal

Recommendation and review posted by Bethany Smith

The menopause used to be ominously referred to as the change an entire life stage relegated to a euphemism. And, although it directly affects half the population, it has remained a stubbornly taboo topic.

Now the shroud of secrecy has finally started to lift. High-profile women are discussing their experiences or even just acknowledging them. Accepting an award on a freezing night in New York, Emma Thompson joked in her acceptance speech: Its such a cold night and its the only time Ive actively been grateful for menopause.

In the past year, parliament has set aside time to debate NHS menopause services and menopause in the workplace for the first time. Menopause cafes have sprung up around the country and Menopause: The Musical has embarked on a nationwide tour.

At the Guardian, we wanted to help drive this change forward. Our editor-in-chief, Katharine Viner, said: The menopause affects half the population, but its a largely neglected issue, both in the media and when it comes to scientific research. We wanted to interrogate the menopause in more depth, give voice to those who have experienced it and explore suggestions for how to make it more manageable for women, in the workplace and beyond.

We assembled a small team of reporters from our health, science and investigations desks. We also wanted to hear from readers, and asked them to get in touch to share their experiences. Responses came in thick and fast several hundred in total.

Many women told us that they felt there wasnt enough information or discussion about the menopause and welcomed the Guardians reporting on it, said Caroline Bannock, the Guardians communities editor.

Women said that the lack of discussion about the menopause meant that they had been unprepared for the experience. Some initially struggled to figure out what was causing their symptoms until a doctor or family member suggested an explanation that should have been obvious.

I consider myself a woman of the world and I didnt know what being perimenopausal was, Meg Mathews, the former music PR, told us. Since experiencing the menopause, Mathews has become a prominent campaigner on the subject.

There was also frustration about the apparently contradictory advice from experts on hormone replacement therapy (HRT). Gynaecologists have tended to highlight the benefits of HRT, while cancer epidemiologists have pointed to the increased risk of breast cancer. Women have been left trying to figure out how to balance the risks and benefits in their own lives.

Many women who got in touch described a wider range of symptoms besides the typical hot flushes that the menopause brings, such as mood swings, depression, brain fog and forgetfulness. But there seemed to be a lack of clear evidence or advice about how these symptoms should be managed.

There were also positive stories and ones that defied menopausal stereotypes: one woman experienced a sudden libido boost (I like to think it was my bodys last hurrah) and embarked on an affair, and another described the post-menopausal zest she felt on the other side. Another described how a GP had made her cry with his kindness, saying I was never dismissed or belittled, a reminder of how much just being listened to can make a difference.

Sarah Boseley and Hilary Osborne covered an ongoing campaign by MPs for workplace policies to protect women going through the menopause: some argue that legislation is needed to bring about reform in this area. The report also revealed the toll that the menopause can take in the workplace, according to a recent survey in which 94% of those attending a menopause clinic said they felt their work had suffered as a result of their symptoms.

The Labour MP Carolyn Harris argued that the menopause should be put on a footing with the kinds of extra support women get during pregnancy: I firmly believe there should be legislation to make sure every workplace has a menopause policy, just like they have a maternity policy.

It became clear that NHS treatment and advice was patchy across the country, with women in some areas getting access to specialist clinics and others simply being recommended HRT. During our reporting, it emerged that even HRT supplies were running out, leaving thousands of women without treatment.

Amelia Hill revealed concerns about some bioidentical HRT products, marketed as being more natural, which experts say are unsafe, expensive and could increase the risk of developing cancer. These drugs are unregulated but widely available, with some women buying products through online pharmacies.

While researching the biology of the menopause, it became clear that the neglect of the subject has extended into the types of research being funded. So much of the basic biology of the menopause is yet to be understood. It is not yet possible to predict when it will occur and who will have symptoms and who wont. Even the role of HRT whether it delays or masks the menopause has not been clearly resolved. Progress is being made, though, with the prospect of a new class of drugs on the horizon and trials showing the benefits of cognitive behavioural therapy and exercise to help manage hot flushes.

The response to our coverage has been overwhelmingly positive and reinforced our belief that there are important stories about the menopause that we should continue to pursue. Younger women want to know what to expect. Women going through the menopause want to know the evidence on treatment and to get the right support in the workplace. Breaking the taboos around the menopause is the only way to ensure that society supports women through this life milestone rather than leaving them to deal with it alone.

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Breaking the menopause taboo: 'There are vital stories we should continue to pursue' - The Guardian

Recommendation and review posted by Bethany Smith

Editors note: This is part two of a four-part Longevity Project: Thriving at Altitude series that will publish on Mondays through Sept. 30. The series also includes profiles on Routt County locals who are thriving at altitude.

STEAMBOAT SPRINGS People living at higher altitudes tend to be healthier, but definitive evidence as to why remains elusive.

There is debatable data, and some contradictory studies, as well as the persistent prospect that, especially in a place like Colorado, a lot of it has to do with selection: healthier people with healthier habits choose to live at higher locations.

Theres also somewhat of a survival of the fittest aspect, noted Dr. WillBaker, a cardiologist with UCHealth Heart and Vascular Clinics in Steamboat Springs and Craig.

Some thrive in a more challenging climate and geography with less oxygen, and some dont.

It also very much depends on the individual, of course.

People with underlying health issues, especially related to the lungs and heart, may find their conditions exacerbated by the altitude.

In general, said Baker, people with chronic lung problems, especially Chronic Obstructive Pulmonary Disease(COPD), will have a harder time living at altitude. The same goes for some heart conditions.

However, there is also research showing altitude having potential protective effects on the heart.

In a 2014 National Center for Biotechnology Information study titled Effects of Living at Higher Altitudes on Mortality, author Martin Burtscher wrote, The available data indicate that residency at higher altitudes are associated with lower mortality from cardiovascular diseases, stroke and certain types of cancer. In contrast, mortality from COPD and, probably also, from lower respiratory tract infections is rather elevated. It may be argued that moderate altitudes are more protective than high or even very high altitudes. Whereas living at higher elevations may frequently protect from development of diseases, it could adversely affect mortality when diseases progress.

In studies spanning the globe, researchers have seen several consistencies in people living at higher elevations: they weigh less, have less cardiovascular disease and some types of cancer and live longer.

But it isnt so straightforward to say that if you come to or are born at a higher altitude, you will lose weight, be healthier and live longer, noted Baker.

Its a lot more complex and so is the available research.

For example, while increased exposure to ultraviolet rays may increase the risk of skin cancer, the increased levels of Vitamin D intake may also have protective effects that profoundly influence cardiovascular mortality, according to Burtscher.

Some studies show people with asthma do better at higher altitudes. Some show they do worse.

And in terms of what Burtscher described as moderate versus high or very high, 6,000 to 7,000 feet can treat a body differently than 9,000 to 10,000 feet.

High altitude to a physiologist starts around 5,000 feet, altitude where the body senses changesin the oxygen level and starts to respond by increasing breathing, according to the Institute for Altitude Medicine in Telluride.

There is a reason the U.S. Olympic & Paralympic Training Center is located in Colorado Springs, noted Dr. BrentPeters, a pulmonologist at UCHealth Pulmonology Clinics in Steamboat Springs and Loveland.

Its 6,035-foot elevation is a sweet spot that provides the most conditioning benefit in terms of ideal oxygen deprivation.

The relationship between lower body weights and altitude comes with several hypothesis.

A 2013 study in the International Journal of Obesityfound a strong association between altitude and obesity in the United States. Using data from more than 400,000 people, researchers foundpeople living closest to sea level were four to five times more likely to be obese, compared to people living significantly above sea level in Colorado.

One possibility is simply that people exercise more though the study did control for that factor and still saw people losing weight.

One theory has to do with eating fewer calories altitude has been shown to increase levels of leptin, a protein hormone that plays a role in appetite control and metabolism. Hypoxia (lack of oxygen) also is known to cause a loss of appetite.

In terms of how a body living at altitude varies from one living at sea level, the primary thing that happens in terms of physiology, said Baker, is that the blood compensates with a higher amount of hemoglobin, which increases the amount of oxygen that can be carried.

One thing Baker does see on a regular basis is more severe impacts from sleep apnea.

Sleep apnea is defined by the Mayo Clinic as a potentially serioussleepdisorder in which breathing repeatedly stops and starts.

Peters, who travels around the state providing care, said he also sees an acceleration or exaggeration of sleep apnea in patients.

They basically dont breathe well at night, Baker said. They wake up frequently and feel fatigued the next day. Often those people sleep better and feel more energetic at sea level.

Theres also a wide spectrum of sleep apnea and different kinds, Peters noted. Most sleep apnea cases are classified as obstructive, in which a person cant breathe normally because of an upper airway obstruction, occurring when throat muscles relax.

Central sleep apnea, which is less common, occurs when your brain doesnt send proper signals to the muscles that control breathing, according to the Mayo Clinic.

Peters said he sees more central sleep apnea in Colorado than other places.

According to a Medlink Neurology report, Central sleep apnea due to high-altitude periodic breathing affects about a quarter of people who ascend to 2,500 meters (8,202 feet) and almost 100% of those who ascend to 4,000 meters (13,123 feet) or higher.

Kids can also experience difficulty sleeping at higher altitudes, said Dr. Steven Ross of Sleeping Bear Pediatrics.

Before they can verbalize how they feel, very young children may seem restless at night and irritable during the day, he said, especially above 7,500 feet.

If a normally energetic kid sits down and whines on the Uranium Mine Trail while hiking or at the top of a ski run, theres a good chance they are experiencing effects of altitude, Ross said, and arent just spoiled and lazy.

And that goes for kids who live here as well as visitors, he said.

When recreating at higher altitudes, Ross advises parents to make sure kids are hydrated and well protected from the sun. Make sure they get good sleep, and factor in patience, he said. Be aware that kids may not have the same endurance they do at lower elevations.

Altitude does play a significant role as babies develop in utero, described Allyson Daugherty, a neonatal nurse practitioner with Childrens Hospital Colorado who cares for newborns in the special care nursery at UCHealth Birth Center in Steamboat Springs.

Babies born at higher altitudes (especially over 8,000 feet) are typically smaller in size.

Altitude contributes to overall growth from a weight perspective, she said.

And, for those tiny developing lungs, mothers making it to the 36-week mark is imperative, she said.

Lungs continue to develop until two to five years of age, Daugherty said, but those last few weeks in utero is crucial, and the primary reason doctors want to see mothers, particularly at higher altitudes, make it to term (40 weeks). The more premature a baby is, the more susceptible the baby is to respiratory distress.

Babies can become hypoxic, she said, and frequently need a little more oxygen during those first few months of life as their lungs mature especially if they are born prematurely.

A lot of babies born at UCHealth Yampa Valley Medical Center are given supplemental oxygen, Daugherty said, as are babies who are born in Denver and travel to Steamboat or are going home to elevations higher than Steamboat.

Even babies who make it to 36 weeks may need some support to continue their lung development after they are born. But those lungs can, and usually do, mature fully after birth without any lasting detrimental effects.

A huge portion of babies (born at YVMC) go home with oxygen whether they are pre-term or term, she said.

The American Academy of Pediatrics recommends parents sleep in the same room as their babies at least up to 6 months of age, Ross said, something even more important at high altitude. The optimal recommendation is sleeping in the same room through 12 months of age.

The good news is, said both Peters and Baker, most people young and old adapt quite well and relatively quickly.

Peters noted that many of his patients are snowbirds, and he asks them to take note of any differences in how they feel living at the different elevations.

Both doctors say it is rare they will tell a patient they should move to a lower elevation.

Only in the most extreme cases, Baker said, will he tell a patient they should move when, even with supplemental oxygen and other medical interventions, in the face of significant lung or heart disease, We just cant keep them in a safe zone.

Of course, many people who do live at altitude, especially as they age, use supplemental oxygen.

Supplemental oxygen, as well as medication, can help people with pulmonary hypertension (high blood pressure of blood vessels in the lungs), which can worsen at higher elevations.

Aside from those rare cases, some people make their own decision if they find they feel more energetic and are able to be more active at sea level, Peters said.

Theres also the eternal importance of maintaining a general level of fitness. Baker thinks this may have more to do with people living longer at high altitudes than anything else.

Its not cut and dry, emphasized Peters. For people, especially as they get older, altitude may stress the lungs, but the low humidity and clean air can also make it easier to breathe. Some people may feel better higher up, some worse.

In a review recently published in USA Today examining 2014 county-level life-expectancy data, Routt County ranked 30th among the top 50 counties across the nation. Cities were not included.

The top three spots for the counties with the highest life expectancy went to Summit (1), Pitkin (2) and Eagle (3).

Given the longevity of those high-up counties as the very highest in the nation, it does add interesting fodder to the question: Is it the type of people living there and their lifestyle, or is there something else in the air?

And there is a growing body of research examining the effects of altitude on the body, seeking to better answer that question.

Still, It all points to the fact that one of the best things people can do is just stay generally fit, said Baker. Thats the best way to enjoy this environment and everything it has to offer.

To reach Kari Dequine Harden, call 970-871-4205, email kharden@SteamboatPilot.com or follow her on Twitter @kariharden.

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Thriving at altitude, part 2: How life at altitude impacts people and animals - Steamboat Pilot & Today

Recommendation and review posted by Bethany Smith

Vegan meat is here. And according to sales data and consumer preference, its here to stay.Food companies are discovering that plants can deliver the same sizzle, bite, and mouthwatering taste as animal-based meat, but without leaving so heavy a mark on our bodies, the planet, and the billions of animals in the food system.

While animal meat has long been viewed as a healthy way to get protein and iron, research continues to point to health hazards.

Meat typically contains high levels of saturated and trans fats, which can raise blood cholesterol. High cholesterol can lead to plaque forming along the inside of the artery walls. This causes the artery to narrow and blood flow to decrease, increasing the risk of stroke, peripheral artery disease, and heart disease. A 2018 study by the Cleveland Clinic found that eating red meat could increase the risk of heart disease 1,000 percent more than a plant-based diet.

In 2015, the World Health Organization (WHO) classified red meat as a Group 2 carcinogen, meaning it probably causes cancer in humans. WHO placed processed meat like bacon and pepperoni in the Group 1 category, which says it is carcinogenic to humans. Tobacco smoking and asbestos are also in this category.

Even small amounts of meat can have a real impact on ones health. An Oxford University study from earlier this year found that eating just three rashers of bacon a day could increase cancer risk by 20 percent.

Eating meat is also connected to the onset or worsening of diabetes, arthritis, liver disease, and kidney disease.

Animal agriculture is a leading driver of a myriad of environmental issues including water pollution, air pollution, ocean dead zones, and species loss.

Beef production was identified as a leading cause of the Amazon rainforest fires since vast swaths of forest are burned intentionally to make room for the production of beef and animal feed; agriculture accounts for 80 percent of all deforestation according to a report funded by the British and Norwegian governments.

The meat industry is also responsible for a significant percentage of all greenhouse gas emissions, which lead to climate change. Last year, Oxford University researchers conducted the most comprehensive analysis of farmings impact on the planet ever conducted. The researchers analyzed data from approximately 40,000 farms in 119 countries and concluded that going vegan is the most powerful tool in the fight against climate change. Lead researcher Joseph Poore said adopting a vegan diet is the single biggest way to reduce your impact on planet Earth, not just greenhouse gases, but global acidification, eutrophication, land use, and water use.

Plant-based meat is just what it sounds like meat made from plants. Pea protein, soy protein, wheat, and mushrooms are commonly used to create juicy meat products.

People love vegan meat the evidence is in the numbers. Data released by The Good Food Institute (GFI) and the Plant Based Foods Association (PBFA) found that vegan meat, chicken, pork, and even seafood are all quickly outpacing their animal-based counterparts.

Sales of vegan meat increased by 37 percent in the past year while sales of animal-based meat only grew by 2 percent. The plant-based meat category is now worth more than $800 million and this figure is climbing. A 67-page report released in July by UBS Group AG, a multinational investment bank and financial services company, said that the plant-based protein market could be valued at $85 billion by 2030.

Unlike animal meat, plant-based meat contains no cholesterol. Dietary cholesterol is only found in animal-based foods, meaning that veganism is the only truly cholesterol-free diet, according to Medical News Today.

Vegan meat is a good source of protein. The plant-based Beyond Burger, for example, boasts 20 grams of protein per serving, which is more than a third of the average recommended daily protein intake. The plant-based Impossible Burger offers 19 grams of protein.

Vegan meat is also rich in fiber. Compare that to animal meat, which contains zero grams of fiber and plant-based protein becomes even more appealing. Earlier this year, University of Otago researchers discovered a connection between a fiber-rich diet and the reduced risk of multiple diseases. Data from 185 observational studies found that those who consume the most fiber are 15 to 30 percent less likely to die prematurely. Eating fiber-rich foods was also linked to a 16 to 24 percent reduced incidence of type 2 diabetes, stroke, and colon cancer.

A Harvard study, which included more than 40,000 healthy men, found that a diet rich in fiber may reduce the risk of coronary heart disease by 40 percent.

Health, the environment, and ethics are seeing more people swap their meat for plants. Major British supermarket Sainsburys released data earlier this year showing that 91 percent of Brits are now flexitarian people who eat animal products but focus on including more plant-based food in their diet.

Another recent survey found that 80 percent of Americans want to replace meat with vegan food. A poll by Angus Reid found that 70 percent of Canadians believe vegan meat is not a passing fad but a movement that is here to stay, and a recent report predicts that the popularity of plant-based meat will boost Australias economy by $3 billion by 2030.These seven meat brands are instrumental in the meat-free movement, helping the masses eat more sustainably and more healthily, but without compromising on taste.

For more than 40 years, Lightlife has been making Food That Shines better-tasting, easy-to-prepare, plant-powered protein.

Lightlifes juicy vegan quarter-pound patty contains 20 grams of protein, 0 grams of cholesterol, and only 2.5 grams of saturated fat, compared to the 80 grams of cholesterol and 9.3 grams of saturated fat in a conventional beef patty.

Lightlifes food is for everyone, not just vegans. As well as the Lightlife Burger, the company produces plant-based chicken, ham slices, and bacon. Lightlifes Smart Dogs are a summertime classic, bringing all the juicy goodness to outdoor barbeques. Earlier this year, the company launched vegan sausages in two meaty flavors Bratwurst and Italian. Both deliver the taste and texture of traditional pork sausages.

Lightlife was a pioneer of the non-GMO movement. The food brand publicly announced in 1999 that all of its products would be free from genetically modified organisms a full eight years before the Non-GMO Project was founded.

Its this forward-thinking attitude that has helped the brand become a favorite across the U.S. The Massachusetts-based brand was credited for helping its parent company Maple Leaf Foods reach $1.02 billion in revenue, up from $9.09.2 million last year. Maple Leaf will soon open a 30,000-square-foot facility which will be used to produce products by Lightlife and Maple Leafs other acquisition Field Roast. The new facility will allow both brands to more than double production capacity. Maple Leaf expects Lightlifes vegan burger will soon be more widely available than the Beyond Burger.

You can find Lightlifes vegan products in the meat aisle at Sprouts, Wegmans, and Foodtown in the U.S; at Sobeys, Walmart, and Metro in Canada; or at a restaurant near you. You can also check the websites store locator.

Field Roast believes food tastes better when its crafted with care. The company stands by the concept that real food is best. So it starts with familiar, high-quality, whole ingredients such as grains, fresh-cut vegetables, herbs, and legumes. Field Roasts artisans then use time-honored charcuterie techniques to carefully craft great-tasting, better-for-you vegan meat.

The company pays homage to regionally beloved spices and ingredients by uniting bold flavors to deliver a complex, layered taste experience.

Field Roast offers products to suit all occasions and meals. Its Apple Maple Breakfast Sausages are perfect for morning meals. Deli slices are ideal for school lunches. Mini Corn Dogs spruce up any social event. And the Celebration Roast is a must for the holidays. For grilling, nothing beats Field Roasts FieldBurger, which is made from barley, carrots, garlic, and onion. The juicy plant-based burger has been winning over sports fans across the country since it was added to stadium menus in 2012.

The companys four sausage varieties are also must-tries, including its new bratwurst which features Elysian Brewing beer from Field Roasts home city, Seattle.

You can find Field Roasts products at Sprouts, Walmart, Whole Foods, Acme Markets, and Safeway in the U.S. and at Sobeys, Metro, and Walmart in Canada. Check out where to find them here.

Naturli is shaking up the food industry with its innovative plant-based meats. Since 1988, the Danish company has challenged the belief that meat and dairy must come from animals. Using ingredients like almonds, coconuts, rice, oats, and soy, Naturli makes cruelty-free, planet-happy food.

Naturli Minced is perfect for an authentic bolognese or a mouthwatering homemade burger. The fresh vegan mince, which can be fried straight from the packet, offers flavors of tomato, porcini mushrooms, and almonds. Its made with peas, which are full of protein and fiber and contain vitamin C and B complex vitamins.

The vegan meat is also better for the planet than its animal-based counterpart; it requires vastly less water and land to produce than beef mince. A comprehensive food analysis by Oxford University researchers found that land use would drop by 75 percent if people replaced beef with plant-based options.

Even the Naturli Minced packaging strives for sustainability the plastic tray that Naturli Minced comes in is made of 80 percent recycled plastic.

The companys Chick Free is the vegan chicken product youve been waiting for. Chick Free, also made from high-quality peas produced in Denmark, is great for curry, wraps, salads, or wherever your imagination and taste buds take you. The packaging for the product is made of at least 50 percent reusable plastic.

You can find Naturlis vegan products in the meat aisle at Sainsburys in the UK, Coles in Australia, Albert Heijn in the Netherlands, and Frs in Sweden. More info here.

Moving Mountains wants to help build a better world. The plant-based meat brand was founded by a vegan environmentalist, Simeon Van der Molen. Simeon wanted to bring amazing plant-based meat to the UK food that had the taste, look, smell, and chew of animal-based meat but contained no animal products. Moving Mountains brings together food technology, incredible scientific processes, specialized machines, and local natural ingredients to make its plant-based hot dog. And the result is unlike any other on the market.

The company uses ingredients including carrot, onion, coconut oil, and sunflower seeds to make the hot dogs. Sunflower seeds are rich in B complex vitamins and offer 6 grams of protein per serving. Coconut oil contains antioxidants and medium-chain fatty acids (MCFAs) which are easily absorbed and metabolized, providing a boost of energy.

But the hot dog doesnt taste like plants. It offers a naturally smoked flavor and tastes so much like pork youll be double-checking the packet.

The company also makes burgers that are hormone-free, cholesterol-free, and antibiotic-free but theyre certainly not taste-free. The protein-packed burger bleeds, cooks, and browns like a conventional beef burger. It even contains 100 percent of your RDA of B12.

You can find Moving Mountains plant-based meats at thousands of locations throughout Europe including Hard Rock Cafe, Applebees, and universities. Moving Mountains will soon be launching globally. Use the store locator here.

The worlds largest food company, Nestl, is tapping into the burgeoning vegan market via its Sweet Earth brand. Sweet Earth is set to launch the Awesome Burger later this year. The plant-based burger is made from yellow pea protein and wheat but boasts the juiciness and taste of beef.

The Awesome Burger offers six grams of fiber per patty and has more protein than a meat burger 28 grams versus a typical 20 grams. The plant-based meat is a good source of iron and vitamin C and has no saturated fat or cholesterol.

Sweet Earths vegan Awesome Burger will hit supermarkets and restaurants in fall. Find the store locator here.

For truly epic veggie eating, look no further than Oumph!. This plant-powered meat brand is on a mission to create great-tasting food thats so good for the planet, you can eat it every day.

Oumph! uses ingredients like beans, apple juice, garlic, tomato, onion, and soy protein to create its super meaty products. Its Pulled Oumph! is perfect for tacos, the Oumph! burger is begging to be grilled, and the companys vegan kebab meat featuring paprika, coriander, ginger, cumin, and parsley can be added to casseroles.

You can find Oumph!s vegan meat at Tesco, Lidl, ASDA, and Whole Foods. Get more info here.

Food company Don Lee Farms might have started out making meat, but now the company says its plant-based patties are better than the real thing.

Don Lees new Better Than Beef Burger which, according to the company, is better on the grill, better for the planet is made with non-GMO ingredients. The thick and juicy quarter-pounder is free from gluten and cholesterol. It joins Don Lees other vegan meat options, like its organic, ready-to-grill Plant-Based Burger. The patty offers 15 grams of protein and contains no artificial ingredients. The vegan burger has proved popular among shoppers; when it first launched at Costco in the U.S., it was purchased one million times in 60 days.

You can find Don Lee Farms vegan meat products at Costco, Kroger, and Ralphs. More info here.

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These 7 Brands Are Making Ridiculously Meaty Vegan Meat

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These vegan meats could help sidestep the health, environmental, and ethical downfalls of animal meat. These brands make the best vegan meat out there.

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Jemima Webber

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These 7 Brands Are Making Ridiculously Meaty Vegan Meat - LIVEKINDLY

Recommendation and review posted by Bethany Smith

Pregnancy pressure might take a toll on a womans mental health. Ovulation predictor kits are offering an easier option to people who have difficulty in conceiving, discovers Ayushi Sharma

Battling infertility, you thought that all roads lead to IVF or surrogacy? But things do not have to always end up at an intensive treatment route. For there are ways to do this in a natural way. The advancement in medical technology means that a clinical device can help you identify and track your fertile window in the comfort of your home.

The need for these arose as the attempt to conceive can be stressful due to rising societal pressure, a ticking biological clock, which, in turn, often leads to repeated clinic visits, blood-drawing and ultrasounds things, which are not just time-consuming but also expensive.

According to State of World Population Report 2019, the fertility rate per woman was 5.6 in 1969, it dropped to 3.7 in 1994, and is 2.3 in 2019. The changed statistics can be attributed to a variety of reasons, which include lifestyle and behavioural changes. With almost one in six couples facing problems in conceiving and one in two couples tracking their cycles incorrectly, there is a need for proactive measures. With changing lifestyles and associated issues, getting pregnant is not as easy as it used to be which in turn has led to the dip in fertility rates considerably.

These devices are doing away with overwhelming trips to clinics for invasive tests that make you feel like you have a huge fertility problem, even when you dont. Fertility monitors can act as personal assistants that help you understand your body and hormones better. While most women believe that their chances of getting pregnant are highest on the 14th day of their cycle, the truth is that ovulation varies from woman to woman and cycle to cycle. Whats more, fertility monitors can help in case of issues like irregular cycles, PCOS, PCOD, thyroid as well, thereby helping you take total control of your fertility, proactively. Taking the guesswork out of the process of conception, it measures estrogen and luteinising hormone levels in your urine to detect peak fertile days in your menstrual cycle.

The best time to conceive is right before a person ovulates or releases an egg because the internal body temperature fluctuates during the menstrual cycle. But it is possible to get pregnant in the days leading up to ovulation, as sperm can survive for several days inside the female body, says Dr Neena Bahl, director, obstetrics and gynaecology, Fortis LaFemme, Greater Kailash II. She adds that testing through fertility monitors is just like doing the pregnancy test. An ovulation kit tests your urine sample to detect a surge in LH (luteinising hormone) levels. While the LH is always present in your urine, it increases 3436 hours before ovulation, which is five times the regular mount. These tests help you find out those days that act as an invaluable tool in your baby-making arsenal. This time is your most fertile window. Having intercourse on those particular days increases your chance of a successful conception.

There are various ways in which one can track fertility. Some ways are as simple as tracking your temperature in the morning as the day your fertile period starts, the temperature goes up by half a degree. Second, to get an ultrasound on any of the 10 days from the ninth day of your period to 19th day, which shows the exact size of the follicle or the egg and once it ruptures, it is the most fertile period to conceive. Third, there are commercially available sticks that tell about the changes in the hormones. Its an indirect way of letting one know that ovulation is going to take place, explains Dr Bahl and tells us that in most cases, ovulation predictor kits provide an accurate forecast of your LH surge and subsequent ovulation. They can be most effective when used together with other monitoring methods. Along with the kits, doctors usually suggest examining the cervical mucus and charting the basal body temperature which is tested the first thing in the morning. These methods, when combined, can greatly increase your chances of getting pregnant.

As there are advantages and disadvantages of everything, Dr Bahl says, The pros are that it is a simpler way of knowing the best possible chance of conceiving. Instead of going to the doctor and getting an ultrasound done, you can choose this method but the con is that it is not as sensitive as the latter. Everytime you are testing yourself, your mind is preoccupied and its obvious when you are trying too hard for something, you get stressed. You do not release happy hormones which in turn affects your ability to conceive. Moreover, your sexual life is timed according to the device and becomes mechanical. It becomes something solely devoted to reproduction. So yes, it can be a rough method but then its obviously a convenient option.

One of the users of the ovulation predictor kits shares her experience. Shweta Verma, 32, a software engineer from Bengaluru, says that they started their family planning after two years of marriage. She was, later in the same year, diagnosed with PCOD and was prescribed a medication for six months. After which, they were advised by the doctors to try conception naturally. The doctor recommended the use of the monitor to ease the journey. I used it for three cycles after which it was discovered that my husband had a low sperm count. I continued using it and even crosschecked the results with ultrasound scans. They turned out to be identical. This strengthened my faith and I finally got the good news, she says and adds that the monitor eases the journey of a woman.

However, these kits do have limitations as they do not work when fertility drugs are present in the system. Moreover, they do not work consistently on women over 40. Some women in their 40s, especially those approaching menopause, have increased levels of LH in their systems at all times, rendering the tests invalid.

But coming to surrogacy or for that matter IVF, these are for people who are infertile or have medical conditions which do not allow them to conceive naturally. Alisha Mathur, 36, a housewife, feels that the device helps women conceive but I dont think it can ever replace doctors or labs or even procedures like surrogacy. It works even for irregular cycles and notifies when there is a probability of a fertility condition or issue which requires clinical support. Surrogacy is a different thing altogether. In the rarest of the rare cases, doctors suggest it.

Dr Bahl explains it better when she says, You cant jump from class one to class 10. Similarly nobody jumps from tracking ovulation to surrogacy. What would a normal healthy couple do? They would try conceiving without any contraception for one year. And 90 per cent of the couples will conceive within one year of married life. So when you dont, you start tracking the fertility manually. But most of the times you would visit a doctor and ask for his/her help. The doctor will then guide the couple about the various methods. Only when they have tried everything and failed does the doctor advise surrogacy. It might be a marketing gimmick that you can avoid surrogacy if you buy this device. However, the trackers just help women conceive quickly.

Using the ovulation predictor kits or so-called fertility monitors provides more privacy as issues like fertility are things that women dont prefer to discuss in public, feel both the users of Inito fertility monitor.

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Time the stork's visit - Daily Pioneer

Recommendation and review posted by Bethany Smith

I suffer from adult acne and its important to break down the myths and talk about the causes, says guest editor Billie Piper. Stylist reveals five misconceptions about the common condition

Synonymous with train-track braces and heavy side fringes, you might think you left acne behind in your teenage years. But for many, that isnt the case. Adult acne a skin condition that occurs when hair follicles become plugged with oil and dead skin cells is on the rise. So while most of us have experienced acne at some point, 15% of women are diagnosed as adults. As a result, Cult Beauty has seen a 66% increase in sales within its acne product category.

Refreshingly, the rise in adult acne is being chased by a growing skin positivity movement. Needless to say, blemishes are a completely normal facet of life and a growing number of us have taken to Instagram to share #skinpositivity posts, chipping away at any shameful stigma that was once attached to the condition. Themovement also celebrates skin acceptance the idea that if youre happy with your acne, thats great, but its also OK if you want to take steps to reduce it.

This weeks guest editor Billie Piper frequently speaks candidly about her experiences with adult acne, and is currently undergoing treatment from renowned skincare expert and go-to celebrity facialist Debbie Thomas at her D Thomas Clinic in London. Debbie had acne as a child, so she understands the impact it has on your skin and your mind, says Billie.

The issue is knowing where to start with acne treatment it can be a minefield, especially when you consider the numerous potential causes and the fact that everybodys skin is different. So, we spoke to Debbie Thomas and dug a little deeper into the five key things you need to know about adult acne.

Type acne into Google and the first images to pop up tend to include severe red cysts. However, acne appears in many different guises: even if you only get one or two spots a month, it might still be medically classed as mild acne.

Acne is simply the medical word for spots, says Dr Anjali Mahto, consultant dermatologist and British Skin Foundation spokesperson. Doctors refer to acne regardless of whether the problem is a small handful of spots or more extensive affecting the face, chest and back. There are six types of spots caused by acne: blackheads, whiteheads, papules, pustules, nodules and cysts. But when is a blemish not acne? These are normally allergy-related bumps which are very small and affect the very surface, says Debbie Thomas. Or theyre related to hair growth and can be irritation from shaving or actual ingrown hairs.

While diet, pollution and lifestyle are often touted as the main causes of acne, hormones particularly those triggered by womens menstrual cycles are the only scientifically proven cause. During the first half of our cycle, oestrogen is dominant and in the second half it is progesterone, says Dr Mahto. Just before menstruation, these hormones drop and our androgen hormones (a type of male hormone) are high. These act on oil-producing glands to increase their size and activity resulting in acne.

Acne could also signal an underlying medical issue. Acne can be a common sign of polycystic ovary syndrome (PCOS), Dr Mahto explains. Studies show that 19-37% of women with moderate or severe acne will meet the criteria for PCOS (having at least two of three symptoms: irregular periods, high levels of androgens or polycystic ovaries).

If acne develops after adolescence, it might be hereditary. Its hard to pinpoint one reason. That is why it is so hard to treat and get rid of permanently, says Thomas. Acne affects people differently, so treatments will vary depending on the severity from medication such as azelaic acid or isotretinoin capsules (also known as roaccutane) to treatments like microdermabrasion. If youre unsure whether a blemish is acne, seek professional advice from a GP or dermatologist.

If your acne is bothering you, it can be tempting to slather on all the super-strength acne-fighting formulas you can find, but its vital to be patient. In fact, before entering the world of skincare, Thomass own acne saw her regularly using harsh products. None of it helped and, a couple of times, I actually burned my skin, she recalls.

The best approach is to strip your skincare back to basics (cleanse and moisturise), adding active formulas in gradually. It can take using an active ingredient like retinol regularly up to nine months to show results, so dont jump from one ingredient to the next, says Thomas.

Cleanse your face twice a day. Products that contain salicylic acid and zinc may be beneficial, says Dr Mahto. After a couple of weeks, start using a chemical exfoliant (like glycolic acid) once a week. This will remove the upper layer of skin cells and help reduce blackheads.

Once your skin has acclimatised, you can introduce an active treatment. For mild acne, a pharmacist can prescribe over-the-counter creams (containing ingredients such as bacteria-killing benzoyl peroxide), but for moderate or severe acne, prescription medication might be best speak to your GP.

If you want to try a clinical treatment, book in for a consultation to ensure your skin is suited to whats on offer. We work with lasers, peels, light therapy and microneedling, alongside a good home care routine, says Thomas.

The psychological impact of acne cant be overlooked. Acne has been associated with anxiety, depression, poor quality of life, lack of self-confidence, feelings of isolation, embarrassment, low self-esteem and problems with body image, explains Dr Alia Ahmed, psychodermatologist at Eudelo Clinic.

Social media can be particularly damaging. The pressure to look perfect can affect the psyche, says Dr Ahmed. I have seen patients who cannot look at an unedited photo of themselves as they find their skin repulsive.

Try following people who encourage positive conversation around skin conditions on social media. And when seeking medical advice, discuss the impact acne is having on your life. If patients are reporting emotional problems, I encourage them to seek support throughtalking therapies and/or oral mood managing medications, if needed, recommends Dr Ahmed, who also flags online resources such as skinsupport.org.uk and changingfaces.org.uk.

Even if your acne fades, scars and pigmentation can be left behind. There is sometimes an unrealistic expectation of how skin should look after acne treatment, says Dr Ahmed. Most scar treatments are not available on the NHS and this can make people feel despondent. Its no surprise, then, that scar treatment is one of the most popular acne-related searches on Cult Beauty.

Clinical treatments differ depending on the type of scar. They are categorised according to shape, depth and colour and the NHS identifies three main types: ice pick, rolling or boxcar. Scars require different forms of treatment but Thomas tends to rely on microneedling, microdermabrasion and peels, while stronger peeling lasers are used for deeper scarring. If it is a textured scar, a certain amount of controlled damage to the skin is required to try and stimulate new collagen production to get the area to repair itself, she explains. The reality is its difficult to get scarring to go completely. Results, which typically display a 30-70% reduction, can take time, with even the strongest treatments often requiring several sessions over one or two years.

High-tech, blemish-relieving formulas that will soothe and treat your skin

Plenaires Tripler 3-in-1 Exfoliating Clay, 30, is an effective mask, cleanser and gentle once-a-week exfoliator.

Murad InvisiScar Resurfacing Treatment, 35, is a daily serum containing salicylic acid and vitamin C to reduce scarring.

Ideal for bumpy, dehydrated skin, CeraVe SA Smoothing Cleanser, 12, doesnt leave skin feeling tight.

When spots appear, apply Squish Flower Power Acne Patches, 12, overnight. The hydrocolloid helps to soothe and minimise.

Apply La Roche-Posay Effaclar Duo+, 16, morning and evening to reduce spots and pigmentation.

Wear No 7 Laboratories Clearing Paste, 18, overnight two to three times a week and wake up to clear, soothed skin.

See the article here:
Acne causes, symptoms and treatments: everything you should know - Stylist Magazine

Recommendation and review posted by Bethany Smith

MRInsights.biz announced that its published an exclusive report namely Global Endocrine System Drug Market 2019 by Manufacturers, Regions, Type and Application, Forecast to 2024 in its research database with report summary, table of content, research methodologies and data sources. The research study offers a substantial knowledge platform for entrants and investors as well as veteran companies/manufacturers functioning in the Worldwide Endocrine System Drug Market. This is an informative study covering the market with in-depth analysis and portraying the current state of affairs in the industry.

This report studies the market with many aspects of the industry like the market size, market status, market trends, and forecast, the report also provides brief information of the competitors and the specific growth opportunities with key market drivers. Market segmentation by companies, region, and type forms an integral part of this report. Historical data available in the report supports the market development on national, regional and international levels. This is an informative study covering the market with in-depth analysis and portraying the current state of affairs in the industry.

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Key Manufacturers Analysis:

The Global Endocrine System Drug market report offers the vendor landscape and a corresponding detailed analysis of the major vendors operating in the market. In short, competitive insights provide an expert view of leading market players and market strategies.

The top manufacturers, exporters, and retailers (if applicable) around the world are analyzed for this research report with respect to their company profile, product portfolio, capacity, price, cost, and revenue. For competitor segment, the report covers the following global Endocrine System Drug market key players and some other small players: Novo Nordisk, Sanofi, Merck, Eli Lilly, AstraZeneca, AbbVie,

For geography segment, regional supply, application-wise, and type-wise major players, demand, the price is presented from 2014 to 2024, covering: North America (United States, Canada and Mexico), Europe (Germany, France, UK, Russia and Italy), Asia-Pacific (China, Japan, Korea, India and Southeast Asia), South America (Brazil, Argentina, Colombia etc.), Middle East and Africa (Saudi Arabia, UAE, Egypt, Nigeria and South Africa).

For type segment, this report focuses on the status and outlook for the product type. The key types are: Diabetes Drug, Human Growth Hormones, Thyroid Hormone Disorder Drugs, Others

For end use/application segment, this report focuses on the status and outlook for key applications. The main applications are: Hospital, Clinic, Medical Center, Others

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Moreover, the report serves the relevant facts and figures collected from the regulatory institutions and other key sources, exploring the growth of the industry for the estimated period (2019-2024). In terms of consumption, this report focuses on the consumption of Endocrine System Drug by regions and application. The research encompasses various factors about the market, its popularity in the global market, segmentation, current trends that are being followed, technological advancements, and future forecasts.

Analytical Tools:

The Global Endocrine System Drug Market Report integrates information regarding significant market members and their market scope. Porters five powers analysis, SWOT investigation, and achievability study are done in this report. Qualitative- and quantitative-wise review was also performed during the analysis.

Customization of the Report:This report can be customized to meet the clients requirements. Please connect with our sales team (sales@mrinsights.biz), who will ensure that you get a report that suits your needs.

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Global Endocrine System Drug Market 2019 Technology Advancement: Novo Nordisk, Sanofi, Merck - Premier Herald 24

Recommendation and review posted by Bethany Smith

Alternative cancer treatment therapies are now a days are actively involved in limiting the growth of cancer. These therapies are also known as precision medicines. Recently alternative cancer treatment have gained increasing focus in the industry as these therapies forms that uses complementary and alternative methods or techniques to prevent, and treat cancer at an earlier stage. Alternative cancer treatment market comprises of acupuncture, aromatherapy, exercise, hypnosis, massage, meditation, music therapy, relaxation techniques, yoga and other alternative therapies. Alternative treatments may not assume an immediate part in curing the tumor, yet they may enable you to adapt to signs and indications caused by various diseases. Basic signs and side effects, for example, nervousness, weakness, vomiting and pain, and stress might be decreased by these natural elective medicines. There are numerous choices one could seek after in elective growth medications and a brainy consolidated approach is regularly the best. In any case, certain elements stay clear and predictable and those are the contributing tumor factors that any treatment should completely address: informational signaling interference fields (bioenergetic blockages), unresolved traumatic emotional conflicts, excess of toxins, inadequate drainage, and failure of nutrient delivery systems.

Alternative cancer treatment market is growing, this is attributed to increasing prevalence of various types of cancers such as lung cancer, breast cancer, colorectal cancer, prostate cancer, lymphoma, leukaemia, melanoma etc. Also increasing awareness regarding natural alternative and complementary therapies such as acupuncture and chiropractic therapy is expected to drive the market over the forecast period. Growing healthcare expenditure, and rising insurance coverage, aids in the revenue growth of alternative cancer treatment market. Top alternative cancer treatment include IPT insulin potentiation therapy, iscador aka mistletoe extracts, Gerson Therapy, Ukrain, biomagnetic therapy, biotherapeutic detoxification & drainage and others. However, less efficacy and impact of these alternative along with less coverage to cure the cancer is expected to hamper the growth of the alternative cancer treatment market over the forecast period. Individuals have started ensuing an all-natural plan and method that included vegetable juicing, probiotic foods, organic, plant-based foods, raw juices, natural and immune-boosting supplements. Other complementary methods include proteolytic enzyme therapy, budwig diet, vitamin c chelation, frankincense essential oil therapy, sunshine and vitamin D3, oxygen therapy and hyperbaric chambers, and others.

The Alternative cancer treatment market is segment based on the therapy type, end user and application

Alternative cancer treatment market is segmented into following types:

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By Therapy Type Hormone Therapies Acupuncture and Dietary Supplements Others

By Disease Indication Gastrointestinal Lung Cancer Breast Cancer Colorectal Cancer Leukemia Lymphoma Melanoma Prostate Cancer Others

By End User Hospitals and Clinics Cancer and Radiation Therapy Centers Home Care Others

Alternative cancer treatment market revenue is expected to grow at a significant rate, over the forecast period. The market is anticipated to perform well in the near future due to increasing awareness regarding various cancer types and their treatment protocols. Also the alternative cancer treatment market is expected to expand globally due increasing prevalence of cancer and increasing preference of healthcare professionals to prescribe supplements for the patients. The natural and supplemented therapies for lung cancer is anticipated to grow with a fastest CAGR over the forecast period, attributed to increasing number of smokers globally. Increasing competition among drug manufacturers, increasing investment in R&D and increasing number of new alternative therapies and dietary supplements are the major factors estimated to drive the revenue growth of alternative cancer treatment market.

Depending on geographic region, the alternative cancer treatment market is segmented into five key regions: North America, Latin America, Europe, Asia Pacific (APAC) and Middle East & Africa (MEA).

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North America is occupying the largest regional market share in the global alternative cancer treatment market owing to the presence of more number of market players, high patient awareness levels, increasing awareness about complementary therapies and marketing activities in the region. Asia Pacific is expected to grow at the fastest CAGR because of increasing prevalence of different types of cancers in the region, thus boosting the market growth of alternative cancer treatment market throughout the forecast period.

Key players of alternative cancer treatment market includes Innovative Medicine, LLC, Esperity, Northwest Natural Health Clinic, and many more. The companies in alternative cancer treatment market are increasingly engaged in strategic partnerships, collaborations, mergers and acquisitions to capture a greater pie of market share as the market is in the nascent stage.

The research report presents a comprehensive assessment of the market and contains thoughtful insights, facts, historical data, and statistically supported and industry-validated market data. It also contains projections using a suitable set of assumptions and methodologies. The research report provides analysis and information according to categories such as market segments, geographies, types, technology and applications.

The report covers exhaustive analysis on: Market Segments Market Dynamics Market Size Supply & Demand Current Trends/Issues/Challenges Competition & Companies involved Technology Value Chain

Regional analysis includes North America (U.S., Canada) Latin America (Argentina, Mexico, Brazil, Rest of Latin America) Europe (Germany, Italy, France, U.K., Spain, Russia, Rest of Europe) Asia Pacific (China, India, Japan, Rest of APAC) Middle East and Africa (Rest of MEA, S. Africa)

The report is a compilation of first-hand information, qualitative and quantitative assessment by industry analysts, inputs from industry experts and industry participants across the value chain. The report provides in-depth analysis of parent market trends, macro-economic indicators and governing factors along with market attractiveness as per segments. The report also maps the qualitative impact of various market factors on market segments and geographies.

Report Highlights: Detailed overview of parent market Changing market dynamics in the industry In-depth market segmentation Historical, current and projected market size in terms of volume and value Recent industry trends and developments Competitive landscape Strategies of key players and products offered Potential and niche segments, geographical regions exhibiting promising growth A neutral perspective on market performance Must-have information for market players to sustain and enhance their market footprint.

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Alternative Cancer Treatment Market Poised to Expand at a Robust Pace Over 2018 2026 - Wolf Mirror

Recommendation and review posted by Bethany Smith

Cultured meat also called lab-grown, cell-based, and clean meat could be on dinner tables sooner than once thought. The futuristic cellular agriculture industry is only becoming busier and some say lab meat could be available as soon as 2021.

Lab-grown meat is produced by in vitro cultivation of animal cells. Cellular agriculturists collect a small sample of cells from an animal. These can come from swabbing skin tissue, a feather, etc. The cells must have a rapid rate of proliferation, like embryonic stem cells, adult stem cells, myosattelite cells, or myoblasts.

The cells are placed into a nutrient-rich solution, called a growth medium, in a controlled cultivator. This causes the stem cells to act as they would if they were still in the animals body to multiply, ideally quickly and into high densities.

The result is an edible product that looks, cooks, and tastes like animal meat because, biologically, it is animal meat. The major difference is that an animal does not need to be killed to make it.

Lab-grown meat is meat, meaning it is not vegan. However, the concept may create a loophole for some due to the fact that it can be made without the slaughter of animals.

Not all lab-grown meat production is free from animal use. Dutch scientist Mark Post, who presented the worlds first lab-grown burger at a press conference in 2013, grew cells in an animal-based broth to make his clean meat patty.

He said the most efficient method of cellular agriculture involves the slaughter of animals. Eventually my vision is that you have a limited herd of donor animals in the world that you keep in stock and that you get your cells from there, Post told The Telegraph.

Fetal bovine serum (FBS) poses an issue for vegans interested in lab-grown meat. FBS comes from the blood of a cow fetus and its the most widely used serum-supplement in the industry for eukaryotic cells.

However, some producers, like food tech company JUST, make a point of keeping the entire process cruelty-free. In a video, JUST shows how it developed its lab-grown chicken. For those very first cells, it was important to us how we got those cells, not just that we got the cells, JUST said. We came up with the idea to use one feather from the single best chicken that we could find.

The team waited for the chicken, whose name is Ian, to naturally drop a feather. The researchers then collected cells from this feather, enabling Ian to live on unharmed, but significantly important to the cause. The JUST team feasted on real chicken nuggets while Ian wandered around their feet, alive and well.

Ryan Bethencourt co-founder of the worlds leading life science accelerator, IndieBio believes lab-grown meat can bridge the gap between peoples hunger for meat and their desire to do less harm. The aim is to ensure that people keep eating what they love, but to produce it in a way so its not damaging the planet, Bethencourt, who is a vegan, said to the Guardian.

Conventional meat comes with its risks. In 2015, the World Health Organization (WHO) named red meat a Group 2 carcinogen, meaning it probably causes cancer in humans. WHO placed processed meat like bacon in the Group 1 category, meaning it is carcinogenic to humans. Asbestos and tobacco smoking are also in this category.

Post believes lab-grown meat could be safer for consumption than traditional meat. The creator of the first clean meat burger said to The Atlantic, We gain greater control over what the meat consists of, for example, its fat content.

And the reduction in the number of farmed animals reduces the chance of zoonosis, he added, referring to infectious diseases that can be passed from animals to humans.

JUST holds a similar view. It said in its video, One of the biggest points of comparison between what were doing and the old way of doing things is food safety.

JUSTs video displays a list of the risks associated with conventional meat, including salmonella, swine flu, giardia, fecal contamination, campylobacter, mad cow disease, foot-and-mouth disease, and avian chlamydiosis. It points out that clean meat carries none of these risks. And when you make that comparison, the difference is staggering, the company says.

Physician Neal Barnard, founding president of the Physicians Committee for Responsible Medicine (PCRM), believes lab-grown meat could be fortified to include extra nutrients like B12, in the same way vitamin D is added to orange juice.

The FDA and the USDA announced in March that they have established a framework to regulate clean meat. Its still in its preliminary stages but that hasnt curbed interest in the concept of clean meat. A study released by The Good Food Institute found that 66 percent of Americans are open to eating meat made in a lab.

Five food companies working within the cellular agriculture industry recently banded together to form the Alliance for Meat, Poultry & Seafood Innovation (AMPS Innovation).

AMPS Innovation aims to educate consumers and stakeholders about the industry and look at effective marketing for their products. The companies are also working with the government to establish a regulatory framework.

The founding members include Fork & Goode, JUST, and Memphis Meats, as well as cell-based seafood producers BlueNalu and Finless Foods. Representatives from these companies have met once a week for the last year to discuss obstacles faced by the industry.

The alliance has formed at an apt time, suggests Lou Cooperhouse, CEO of BlueNalu. This industry is maturing and is a lot more near-term than was thought of in the last year or in the past, Cooperhouse said in a statement. This is not something that is 10 years away. It is something that is short-term.

Lab-grown meat is not commercially available yet, but its launch may not be far off.

A recent report by global consultancy AT Kearney stated that by 2040, most of the meat people eat will not come from slaughtered animals. Sixty percent of meat will be either plant-based or cultivated in a lab.

The large-scale livestock industry is viewed by many as an unnecessary evil, the report said. With the advantages of novel vegan meat replacements and cultured meat over conventionally produced meat, it is only a matter of time before they capture a substantial market share.

It later added, Cultured meat will win in the long run.

Traditional animal agriculture leaves an undeniable mark on the planet. Its resource-intensive and generates huge amounts of greenhouse gas emissions. The United Nations Environment Programme (UNEP) named meat the worlds most urgent problem, saying that using animals for food has brought us to the verge of catastrophe.

The greenhouse gas footprint of animal agriculture rivals that that of everycar, truck, bus, ship, airplane, and rocket shipcombined, UNEP said. There is no pathway to achieve the Paris climate objectives without a massive decrease in the scale of animal agriculture.

Swapping to lab-grown meat could alleviate some of this damage. The CEO of Memphis Meats Uma Valeti said to the Guardian, If the US switched to Memphis Meats beef, we would expect the greenhouse gas reduction to be like taking almost 23m cars off the road. One burger could save the amount of water used in 51 showers.

Tim Noakesmith the founder of VOW, which is working on lab-grown kangaroo meat believes cell-based meat could help feed the worlds growing population. Its pretty insane, but its super important, its incredibly important, he said to Nine News. Weve reached the scale capacity in terms of creating food using traditional animal agriculture and we see that meat consumption is going to be rising and rising over coming decades.

VOW says its lab-grown kangaroo meat could be in supermarkets by the end of 2022. Its also speaking with top-tier chefs in Australia to explore the incorporation of its product into meals.

Other lab meat producers have similar goals. Japanese startup IntegriCulture Inc. wants to see its slaughter-free foie gras served in restaurants by 2021 and on the consumer market by 2023.

CEO of JUST Josh Tetrick took to Twitter in October to tease the launch of JUSTs lab-grown chicken nuggets. The company hasnt announced concrete plans, but Tetrick took the cruelty-free nuggets to the UK in January so that English TV presenter Helen Skelton-Myler could taste-test them. Tetrick explained, It is a nugget that didnt require killing a chicken and thats the way all meat should be. We dont need to choose between veggie burgers and a real burger.

Even the meat industry is clocking on to the notion. Agricultural giant Cargill invested in lab-grown meat company Aleph Farms earlier this year. Cargill, which controls more than 20 percent of Americas domestic meat market, has also invested in Memphis Meats.

Major meat producer Tyson Foods has also invested in Memphis Meats. Its also an investor in Israeli clean meat startup Future Meat Technologies. Justin Whitmore, Executive Vice President, Corporate Strategy and Chief Sustainability Officer of Tyson Foods, spoke about the move at a panel event in 2018. We dont want to be disrupted, he said.We want to be part of the disruption.

Summary

Article Name

What Is Lab Meat and Is It Vegan?

Description

Cultured meat -- also called lab-grown, cell-based, and clean meat -- could be available as soon as 2021. But what is lab meat? And is lab meat vegan?

Author

Jemima Webber

Publisher Name

LIVEKINDLY

Publisher Logo

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What Is Lab Meat and Is It Vegan? - LIVEKINDLY

Recommendation and review posted by Bethany Smith

Blood vessels are the lifeline of any organ.

The dense web of channels, spread across tissues like a spider web, allow oxygen and nutrients to reach the deepest cores of our hearts, brains, and lungs. Without a viable blood supply, tissues rot from the inside. For any attempt at 3D printing viable organs, scientists have to tackle the problem of embedding millions of delicate blood vessels throughout their creation.

Its a hideously hard problem. Although blood vessels generally resemble tree-like branches, their distribution, quantity, size, and specific structure vastly differs between people. So far, the easiest approach is to wash out cells from donated organs and repopulate the structure with recipient cellsa method that lowers immunorejection after transplant. Unfortunately, this approach still requires donor organs, and with 20 people in the US dying every day waiting for an organ transplant, its not a great solution.

This week, a team from Harvard University took a stab at the impossible. Rather than printing an entire organ, they took a Lego-block-like approach, making organ building blocks (OBBs) with remarkably high density of patient cells, and assembled the blocks into a living environment. From there, they injected a sacrificial ink into the proto-tissue. Similar to pottery clay, the ink hardens upon curingleaving a dense, interconnected 3D network of channels for blood to run through.

As a proof of concept, the team printed heart tissue using the strategy. Once the block fused, the lab-made chunk of heart could beat in synchrony and remained healthy for at least a week.

The technology, SWIFT (an eyebrow-raising backcronym of sacrificial writing into functional tissue), is a creative push into a new generation of 3D biofabrication. Although OBBs have been around, the team explained, little attention was previously paid to putting the Lego pieces together with blood vessels.

This is an entirely new paradigm for tissue fabrication, said study author Dr. Mark Skylar-Scott. The focus is on vessels, which will support 3D printed living tissue that may eventually be used to repair damaged parts of a natural body, or even replace entire human organs with lab-grown versions, he added.

[Its] beautiful work, commented tissue engineer Dr. Jordan Miller at Rice University, who was not involved in the study.

SWIFT straddles two wildly diverse fields across centuries: organoids and 15th-century lost-wax sculpturing.

Youve heard of organoids. Often dubbed mini-organs, these lentil-sized blobs of tissue remarkably mimic particular aspects of entire organsbrain organoids, for example, show the characteristic nerve cell types of firings of a preemie baby. The cellular inhabitants that make up organoids are what especially caught the teams attention: most are grown from induced pluripotent stem cells (iPSCs), which are often skin cells de-aged in a way that they can develop into almost any cell type with a little chemical prodding.

Because organoids are built from a patients own cells, theyre completely compatible with the host for an immune standpoint. That particular strength caught the teams attention: organoids, they reasoned, make the ideal OBBor Lego piecesto biomanufacture patient- and organ-specific tissues with all the desired properties.

For example, the team explained, organoids are packed with a high density of cells, which is usually hard to achieve with traditional 3D tissue printing. Under the right conditions, they also develop similarly to real organs in terms of cellular composition and microarchitecture to support functionfor about a year. Without a blood vessel network, all organoids die.

Heres where lost-wax technique comes in.

First, a very brief explainer. Throughout the Renaissance, the majority of Italian sculptors used the technique to fabricate bronze statues. In the simplest method, a statuette is first modeled in beeswax and covered in potters clay. Once dried, the assembly is heatedthe clay is fired into ceramics, and the wax melts and flows away (hence, lost). Once cooled, the entire project is now a hollow ceramic mold, through which the artist can pour in molten metal.

Now, replace beeswax with sacrificial bio-ink, and thats pretty much how SWIFT carves out its intricate tunnels of blood vessels.

The entire fabrication process is two main steps. The team first grew hundreds of thousands of proto-organoids inside culture dishes. These tiny blobs are so small they dont yet need to be churned inside a bioreactor, but theyre mightily packed with roughly 200 million cells every milliliterabout the bottom bit of a teaspoon. These make up the techniques building blocks, or OBBs.

Next, roughly 400,000 OBBs are mixed with a dense, gel-like liquid with the consistency of mayonnaise at a low temperature. The liquid is filled with collagen, a protein that keeps our skin elastic, and other synthetic versions. The OBBs are now somewhat suspended inside the gel-like matrix, which is ideally suited for creating vascular channels, the team said. Altogether, the organoids and gel are compacted into a density similar to human tissue, making up the raw material for further sculpting.

Now the fun second step. Using a 3D printer, the team moved a tiny nozzle containing both harmless red ink and gelatin into the mixture, depositing both in a pre-programmed manner. In this way, the team was able to draw intricate branch-like patterns into the organoid-gel mixture. Similar to squeezing frosting out of a bag, the team was able to adjust the diameter of the gelatin ink by nearly two-fold, mimicking the usual structure of blood vesselsthick main channels that increasingly become tinier.

Once the network was fully printed, they then gently heated the mixture to body temperature. The matrix stiffens, and the gelatin inkacting like Jello left under the sun for too longmelts and is washed away. What remains is a network of OBBS, or organoids, linked with a vascular structure that can now be filled with blood.

As a proof of concept, the team went straight for the heartcardiac tissue, that is. They repeated the steps using heart-derived cells, and kept the resulting chunk of heart, a little bigger than half an inch inside a chamber, filled with a nutritious, oxygen-rich bath.

Within a week, individual organoids embedded inside the gel fused together into a collective: the tissue was able to contract almost 50 percent better than immediately after printing, and the beating rhythm synchronized, suggesting that the lab-grown tissue had further matured.

The tissue even reacted similarly to a normal heart. When the team infused a drug that increases heart rate into those printed vessels, the tissue doubled in its heartbeat. Similarly, drugs that normally decrease heart muscle contraction also worked on the mini-heart. As a final proof of concept demo, the team printed a chunk of heart tissue with a branch of the coronary arterya main blood vessel branch that normally wraps the heart.

The new study is hardly the first try at printing organs with blood vessels. Miller, for example, biomanufactured a hydrogel that mimicked a lung air sac earlier this May. Layer by layer, the precise anatomy of the lung-mimicking structure is constructed with liquid hydrogel, and solidified using light.

The new study stands out in its sheer creativity. By combining organoids with an ancient sculpture technique, the team was able to pack far more cells into the resulting structure, while tapping into the natural mini-organization that stems from organoids. The results arent just promising for printing larger, more intricate human organs with a blood supplythey could also help inform organoid research, which has struggled to keep the pseudo-organs alive.

The team is planning to transplant their SWIFT tissue into animals to further examine their function and health. But to the team, the main goal is to finally bring 3D-printed organs to people desperately on the transplant waiting list.

Our method opens new avenues for creating personalized organ-specific tissues with embedded vascular channels for therapeutic applications, they said.

Image Credit: Wyss Institute at Harvard University / CC BY-NC-ND 4.0

Read more from the original source:
How a Centuries-Old Sculpting Method Is Helping 3D Print Organs With Blood Vessels - Singularity Hub

Recommendation and review posted by Bethany Smith

Dr. Freda Miller, a senior scientist at the Hospital for Sick Children, has discovered that stem cells found in adult skin can produce nervous system Schwann cells.Fred Thornhill / Toronto Sun

A new elementary school in the citys southwest is being named after a scientist who is an alumna of the Calgary public school system.

The school that is under construction in the community of Evergreen is called Dr. Freda Miller School. The Board of Trustees of the Calgary Board of Education approved the name for the school, which is expected to open in September 2020.

Miller is a cell and molecular developmental neurobiologist at Torontos Hospital for Sick Children and a professor at the University of Toronto. She is also a fellow of theRoyal Society of Canada and the American Association for the Advancement of Science.

Miller has made seminal scientific discoveries over the course of her career, the Calgary Board of Education said in a news release Monday.

Her discovery of stem cells in the second layer of the skin has provided the conceptual basis for using skin as a major source for genesis of human stem cells. The stem cells she discovered are critical for the repair of injured skin, the release stated.

At the same time, Dr. Miller discovered new mechanisms determining whether nerve cells live or die, findings that initiated new fields of research and that have major implications for our understanding of neurodegenerative disorders.

Miller attended schools in Montgomery and Bowness and was part of the gifted program at Queen Elizabeth High School in her junior high years. She has a PhD in medical sciences from the University of Calgary.

The school board said Miller maintains strong ties to Calgary and lives part time in Canmore.

When Dr. Freda Miller School opens, it will serve students from kindergarten to Grade 4.

The rest is here:
New elementary school in Calgary named after scientist - Calgary Herald

Recommendation and review posted by Bethany Smith

Currently, there is no licensed treatment to slow or stop the progression of Parkinsons disease. However, a team at Sheffield University in the UK are currently working to identify compounds that target the dopaminergic brain cells affected by the disease. Nikki Withers speaks to Dr Heather Mortiboys to hear how their work could potentially slow disease progression.

Presenting as the second most common neurodegenerative condition after Alzheimers, Parkinsons disease affects 148,000 people in the UK alone. Most people present to their doctor with movement symptoms, such as a tremor, which is a classical symptom and what people often associate with Parkinsons, explains Dr Heather Mortiboys, from the University of Sheffields Institute for Translational Neuroscience (SITraN) and the Universitys new Neuroscience Institute. However, there are other symptoms that occur prior to the movement symptoms, such as loss of sense of smell, autonomic disturbances such as constipation and disordered sleep, particularly in REM sleep.

Most patients with Parkinsons are termed sporadic or idiopathic; meaning the cause of the disease is unknown. Only about 10 percent of patients develop Parkinsons through a known gene mutation, although some genetic association studies have identified several genes that might increase a persons risk of developing Parkinsons, according to Dr Mortiboys, who adds that this does not mean that the person will develop the disease.

Dr Mortiboys has been working in Parkinsons research for over 18 years and currently holds several senior positions, including Senior Research Fellow for Parkinsons UK. When asked about the aetiology of the disease, she explains: We know the type of brain cells that are lost in Parkinsons. They are in a specific brain region the midbrain and they contain the neurotransmitter dopamine. However, we dont know why these cells fail to function properly.

The team used a reprogramming technique utilising the patients skin cells to generate induced neuronal progenitor cells

Dr Mortiboys main research focus of late has been understanding what causes these dopaminergic cells to die in Parkinsons patients. If we can identify what is happening at the cellular level, then we can try to target them with drug therapy to stop them dying, or at least slow it down, she explains. Her team has focused their research on the cells powerhouse the mitochondria. Dopaminergic brain cells are heavily reliant upon their mitochondria. We know that in people with Parkinsons, the mitochondria dont function properly, but we dont really understand the reason why. We also dont know whether we can increase that function and if so, whether that will stop or slow the brain cells from dying.

To study the function of the mitochondria in patients with Parkinsons, the team took skin biopsies from the forearms of patients and cultured the cells in the laboratory. We took a large number of skin cells from a variety of different people with Parkinsons; some with a genetic type that causes early-onset Parkinsons, some with a genetic type that causes later-onset Parkinsons and then the largest group of patients was those with an unknown cause, explains Dr Mortiboys. Once the skin cells had been obtained, the researchers were able to investigate how well the mitochondria, and the associated pathways, functioned. As expected, we found that in all the patients, the mitochondria were not functioning properly in their skin cells. We also noticed that there were problems with the cells recycling pathways.

The next stage of their project was to identify a compound that would have a beneficial effect on boosting mitochondrial and lysosomal function. We started off with all of the drugs that are currently in clinical use, which was around 5,000, says Dr Mortiboys, noting that when developing a drug for neurodegenerative conditions, it needs to pass through the blood-brain barrier. Instead of screening all 5,000 drugs in the laboratory, we performed in silico computer screening to rank the compounds in their ability to pass through the blood-brain barrier.

Once the initial computer-based screening had been performed, the team ran a secondary screen to rank the compounds on their clinical characteristics. We looked at their known side effects, metabolism and dose range, says Dr Mortiboys. We ended up with a rank list of all the clinically in-use compounds and then screened the top ranked of these compounds in the patients cells for their beneficial effect on the mitochondria in the skin cell.

Since their initial work focused on patients skin cells, the team needed to validate their findings in dopaminergic brain cells, which are lost in Parkinsons. This can be particularly challenging because we cant easily take a brain biopsy from a patient, says Dr Mortiboys. The team therefore used a reprogramming technique utilising the patients skin cells to generate induced neuronal progenitor cells. We used a slightly modified protocol, which doesnt take the cells all the way back to being stem cells, explains Dr Mortiboys. Our method takes them to an intermediate, which can only become brain cell types. Crucially for us, it doesnt take them back to the embryonic state. The reason for this is that age is one of the biggest risk factors for Parkinsons and many other neurodegenerative conditions. We didnt want to wipe all the age-associated changes in the cell; so, with this reprogramming technique, we retained the changes that had happened throughout the cells lifetime while still producing a high percentage of dopaminergic cells.

Once these cells had been cultured, the team studied their mitochondrial function and observed that they were far more defective in the patients brain cells than in their skin cells. This showed us that it did matter which cells we were looking at it really was a problem with the mitochondria in the dopaminergic brain cells, explained Dr Mortiboys.

Building on their previous work, the team then looked at the beneficial effects of the previously identified compounds on the dopaminergic brain cells. We had identified several compounds that boosted mitochondrial function in the skin cells and we wanted to see their effects on the brain cells. For example, would they stop them dying off? Are they healthier when they have been treated with the compound? Do their neuronal features change?

Dr Mortiboys explains that they were able to identify compounds that had a beneficial effect, and this will be the focus of their research over the next year. With funding through the Virtual Biotech Programme the drug development arm of charity Parkinsons UK our aim is to take several of these lead compounds and chemically modify them. Well then test these chemicallymodified compounds in the dopaminergic patientderived system.

The aim is for the team to identify a lead molecule that retains mitochondrial function and can be progressed through the drug discovery pipeline.

As with all drug discovery research, there are several challenges the team must address. I think, going forward, the challenge for this project will be to fine tune the chemical lead compounds to dial up the beneficial effects and dial out the less desirable effects. Then, of course, there is the challenge of being able to test something in the laboratory and have confidence that it will translate into a beneficial effect in the clinic, says Dr Mortiboys.

Commenting on Dr Mortiboys research, Richard Morphy, Drug Discovery Manager at Parkinsons UK, said: This is an exciting new approach that could rescue defective mitochondria inside neurons to prevent dysfunction and degeneration of dopamineproducing brain cells. We hope the project will identify a superior group of molecules that could one day deliver a life-changing drug for people living with the condition.

The main symptoms of Parkinsons disease are:

A person with Parkinsons disease can also experience a wide range of other physical and psychological symptoms. These include: depression and anxiety, balance problems, loss of sense of smell (anosmia), problems sleeping (insomnia), memory problems.

Parkinsons disease is caused by a loss of nerve cells in part of the brain called the substantia nigra, which leads to a reduction of dopamine in the brain. Dopamine plays a vital role in regulating the movement of the body. The exact cause of the loss of nerve cells is unclear. Most researchers think that a combination of genetic and environmental factors is responsible.

Parkinsons disease affects around one in 500 people. Most people with Parkinsons start to develop symptoms when theyre over 50, although around one in 20 people with the condition first present with symptoms when theyre under 40. Men are slightly more likely to get Parkinsons disease than women.

Dr Heather Mortiboys gained her PhD from the International Max Planck PhD Program in Dresden, Germany in 2006. She then worked in the Neurology department at the University Hospital Dresden as a research associate on an EU funded project investigating coenzyme Q deficiency in patient tissue. Heather joined the Neuroscience department at the University of Sheffield to set up mitochondrial investigations in models of Parkinsons disease working as a postdoctoral research associate with Professor Oliver Bandmann. She recently became a Parkinsons UK Senior Research Fellow based within the Sheffield Institute for Translational Neuroscience (SITraN) to continue and expand this work setting up her own laboratory.

Original post:
Slowing progression in Parkinson's - avenues to explore - Drug Target Review

Recommendation and review posted by Bethany Smith

Since its launch in 2014, MONAT has taken the beauty world by storm, launching vegan, efficacious hair products and developing a massive global fanbase. Today, the brand is launching its highly anticipated skin-care collection, which has had 1 million VIP customers eagerly awaiting its arrival. Luckily for me, I was able to get my hands on the products early, and the complexion-perfecting formulas did not disappoint! Here's the scoop.

You May Also Like: Everything to Know About Stem Cells in Your Skin Care

Designed for busy people who need to glow on the go, the products are split into two collections: Be Gentle (Creamy Cleanser and Nourishing Moisturizer for dry and sensitive skin types)and Be Balanced (Foamy Cleanser and Lightweight Moisturizer for normal and combination skin types). Both duos are paired with the Skin Revitalizing Essence ($45) and Rewind Age Control Nectar ($120).There are also two special treatmentsa Berry Refined Scrub ($58), which is my personal favorite in the roundup that also doubles as a mask, and Eye Smooth ($75), which is literally one of the smoothest eye creams I've ever tried. A common thread throughout the line is the dreamy textures: think whipped butters and silky creams that make tedious skin-care routines feel luxurious.

And the creation of two collections adds that extra thoughtful touch we all look for these days. "How a product absorbs into the skin varies based upon an individualsskin type. Therefore, different skin types need different care," says Marlene Garcia, licensed medical aesthetician and the brand's senior manager of skin care education. "We formulated theMONAT Skincare line taking into consideration the science behind productabsorption into the skin because absorption plays an important role in how wellproducts can help optimize skin texture and elasticity while the minimizing theappearance of fine lines, wrinkles and age spots.

One big claim to fame for MONAT is that its formulas are "clean," and these new skin-care products are no exception. "MONAT literally means Modern Nature," says Jamie Ross, senior vice president of technical services and the brand's head of R&D."We use ingredients that arenaturally based, safe, pure and sustainablethe best nature has to offerbut we combine them into unique complexes that make thesenaturally based ingredients work in harmony with each other to pump up their existing properties. This is what takes MONATformulations to the next level. Weare also a global brand, and our skin care meets the rigorous cleaningredient standards of the EU. We have a go-to list of potentiallytoxic ingredients we will never use, and we're also cruelty-free and vegan. Aboveall, anything we bring to market must perform. Its one thing to be clean, but another to be clean andachieve the highest performance possible."

You May Also Like: How Easy Is It to Make the Switch to 'Cleaner' Living?

In regards to performance, one of MONAT's cult-favorite productsREJUVENIQE Oil Intensiveinspired its skin care. "We are known for our intensive hair oil, which has a base of Abyssinian oil and an invigorating, proprietary blend of 13 natural plant extracts and essential oils that are rich in omega fatty acids, antioxidants and nutrients," says Alan Meyers, the brand's chief science officer."The products primary role is a hair oil, but we had thousands of customers using it on their skin, too. When we officially launched into skin care, we took this same REJUVENIQE blend and carried it into our star products, including Rewind Age Control Nectar($120)."

Fans had been requesting skin care from the brand for years, but MONAT wanted the formulas to bring something new to the market rather than launching a line because everyone else was. That's one reason why brand presidentStuart MacMillan stressed the importance of doing clinical trials (a step many brands don't take due to the expense and time required). "We wanted to be naturally based AND efficacious," he says. "We wanted to be a disruptorwith key elements that made us unique. As such, the credibility of the productwas essential to us. Clinical trials reinforce the efficacy of our products andprovide credibility and confidence for our distributors." The results of such trials revealed 24 hours of skin hydration, and after14 days, 100 percent of users saw improvements to their skinsbalance, appearance and texture, and a more even skin tone.

You May Also Like: 22 Beauty Gifts Dermatologists Give Their Friends and Family

My personal favorite from the line is the Berry Refined Scrub, which smells like a Capri Sun, feels super gentle on my skin but is powerful enough to exfoliate away grime, and leaves my skin feeling SO soft. It also contains the brand's signatureREJUVENIQE blend, and it'sthe perfect skin prep for the Skin Revitalizing Essence, which has asubtle peach scent and watery texture that sinks right in.

You can buy the two collections (four products each) as sets for $278, or pick and choose, as each product is sold separately as well. Which one are you excited to try first?

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MONAT Just Launched a Skin-Care Line and It's Everything You Hoped For - NewBeauty Magazine

Recommendation and review posted by Bethany Smith

Add this to your skin care kit

We're fortunate to be in an age where there's a solution for every skin problem that exists. Under the massive umbrella that is skin aging, there are many concerns and so many proposed solutions that it can befuddle the mind. We suggest you start off with an anti-aging serum. Serums contain higher proportion of active ingredients and penetrate deeper into the skin, which means better chances to improve texture, reduce lines and better elasticity. These 9 anti-aging serums are ideal for those with mature skin to target concerns of wrinkles, fine lines, age spots and sagging.

(Also Read:7 Sheet Masks For Every Anti-Aging Skin Concern)

The Plum Bright Years Age Specialist Cell Renewal Serum is powered by plant stem cell extracts that promote renewal, fight wrinkles and tighten skin in a 100% vegan and cruelty-free formula that comes in recyclable packaging.

The Biotique Bio Dandelion Visibly Ageless Serum has a preservative free blend of pure dandelion and nutmeg oil which are rich in vitamin E and minerals to brighten its tone, reduce spots as well as wrinkles.

The L'Oreal Paris Revitalift Laser X3 Renewing Anti-Aging Serum is inspired by dermatological procedures with concentrated actives like 3% Pro-Xylane and Adenosine. They work rapidly to provide triple action by smoothening skin, refining its texture and reducing wrinkles and lines.

The Lotus Professional Phyto-RX Intenstive Repair Anti-Aging Serum boosts production of collagen which lends skin with firmness and elasticity.

The Olay Regenerist Micro-Sculpting Serum is formulated with hyaluronic acid pentapeptides which penetrates the surface to regenerate cells from within which makes the face firmer and more lifted.

The Dot & Key Time Reverse Retinol Serum has peptide technology without parabens, sulphates or alcohol to minimize lines, fade spots and tighten skin.

The VLCC Vitalift Serum contains comfrey and soy to tighten skin and fade wrinkles in all skin types.

The La Roche-Posay Hyalu B5 Serum targets skin that is riddled with wrinkles, fine lines and sagginess. With hyaluronic acid and vitamin B5 as its heroes, it replenishes the skin's moisture barrier and activates renewal of cells.

The Sage Apothecary Face Serum has a host of ingredients like vitamin C and E, goji berry and hyaluronic acid which firms skin, reduces lines and shrinks pores.

Shop for similar serums here.

Add this to your skin care kit.

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9 Anti-Aging Serums That Will Turn Back The Clock On Your Skin - NDTV

Recommendation and review posted by Bethany Smith

By TNH Staff September 20, 2019

(NASA, ESA, S. Beckwith (STScI), HUDF Team via AP)

A 31-year-old Greek woman who has racked up international acclaim as a renowned scientist isnt one, academics said, and the US space agency NASA said she never worked there as she claimed.

Eleni Antoniadou, 31, has won praise and awards around the world for her supposed work in a wide range of fields, including regenerative medicine, artificial organ bioengineering and space medicine at NASA.

The British newspaper The Telegraph said it was told by NASA she had not been on the staff there and university professors also disputed her assertions, undercutting her frequent appearances n the media and her claims for international achievements and as she was just presented an achievement award by Greek Education Minister Niki Kerameus who said, Her passion for science inspires us and fills us with optimism.

A Facebook post by Costas Bouyioukos, assistant professor of bioinformatics at Paris Diderot University in France that went viral went even further in discrediting her as he said She is not even fit to be called a scientist for most people.

Bouyioukos said she only and only completed the space agencys Frontier Development Lab, an eight-week educational program.

Antoniadou, the inspiration for Greeces first Barbie doll, has been described as a specialist in the fields of regenerative medicine, artificial organ bioengineering and space medicine, as well as training astronauts at NASA, and working as CEO of Transplants Without Donors, which creates artificial organs for transplants, the paper said.

She has been called a Greek scientist of global calibre by Greek media and was voted 2013 Woman of the Year at the annual British FDM Everywoman in Technology Awards, winning the NASA-ESA Outstanding Researcher Award in 2012 which doesnt appear to be real and presiding over the European Health Parliament.

Greek Hoaxes, a team which debunks fake news, also dismissed her claim to have worked on a team that built the first trachea implant to be successfully used on a patient at University College London, saying the patient died afterwards, the paper reported.

She issued a statement on Facebook saying she was working on a project on artificial intelligence for NASA but would not comment to the paper while a spokesperson for the agency said she was not an employee there but couldnt say if she had worked as a sub-contractor on projects.

The National Herald earlier wrote of her achievements as well, saying that he had said of her motivation: Love another person, even when they lose themselves, when their hygiene is failing, when they dont eat, when they dont care if they are in the light or the darkness. When they have given up and you want to give them a kick and put them to bed. Love, even when youre not sure its worth it. Admire them, even if they look at you without actually seeing you.

She had said she was a researcher in the interdisciplinary fields of regenerative medicine and bioastronautics, specializing in the regeneration of artificial organs from stem cells as an alternative therapeutic pathway for transplants and worked on the creation of cerebral implants, artificial skin, muscles, ears, nerves and the esophagus.

She said she designed a series of bioreactors and tissue engineering tools and has created the worlds first amniotic fluid stem cell bank, conducted experimental studies on the development of bio-nanotubes as drug carriers for targeted cancer therapies, as well as clinical trials for stem cell therapies for lung cancer.

Antoniadou also said she was on the Advisory Committee of the Research and Analysis Organization, DIANEOSIS, in Greece and had been honored by the European Patent Organization in Germany but there were no reports in the wake of others challenging her background whether any of what she said she had done was true.

Read the original here:
Greek Woman's Claim to Be Scientist Refuted by NASA - The National Herald

Recommendation and review posted by Bethany Smith

MedicalResearch.com Interview with:

Dr. Ke Cheng, PhDProfessor, Department of Molecular Biomedical Sciences, NCSUProfessor, UNC/NCSU joint Department of Biomedical Engineering

MedicalResearch.com: What is the background for this study? What are exosomes?

Response: People are developing lots cosmetic products to keep a healthy and young appearance, like antioxidants, growth factors, peptides and more recently, stem cell products. Also, people are seeking more effective solutions for better absorption, like lotion, mask, laser and fillers. What is used for the treatment and how to deliver it are vitally important to the final effect and lasting time.

Exosomes are nano-sized small vehicles containing proteins, nucleic acids, and they are messengers for cell communication and regulation. Here we use skin cell-secreted exosomes to fight skin aging.

MedicalResearch.com: What are the main findings?

Response: We are proposing a cell-free, needle-free treatment to treat aged skin. Exosomes-treated skin was significantly refined and improved compared to commercial retinoids. Whats more, needle-free jet injector is excellent for the delivery of exosomes. The exosomes can reach deep dermis and still maintain their biological activity.

MedicalResearch.com: What should readers take away from your report?

Response: Exosomes play an important role in cell-free treatment and clinical translation. I think skin cell-derived exosomes hold great potential in rejuvenating skin cells, also, they can penetrate dermis well via jet injection methods. For lotions and mask, bioactive factors are hard to penetrate through stratum corneum, you must apply them daily to keep skin hydrated and smooth. This needle-free injection could achieve a long-lasting effect.

MedicalResearch.com: What recommendations do you have for future research as a result of this study?

Response: Cells are communicating with each other by secreting messengers. It is important to realize the messengers could be different when cells are at different state, like 2D culture, 3D spheroids, treated with drugs and cocultured with different types of cells.

MedicalResearch.com: Is there anything else you would like to add? Any disclosures?

Response: The limitation of this study is the lack of immunological study. Even though it is cell-free treatment, we would like to do more assessment in the future.

Citation:

Needle-Free Injection of Exosomes Derived from Human Dermal Fibroblast Spheroids Ameliorates Skin Photoaging. Shiqi Hu, Zhenhua Li, Jhon Cores, Ke Huang, Teng Su, Phuong-Uyen Dinh, Ke Cheng*.

ACS Nano. 26 Aug 2019.https://doi.org/10.1021/acsnano.9b04384

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Last Modified: Sep 19, 2019 @ 6:21 pm

The information on MedicalResearch.com is provided for educational purposes only, and is in no way intended to diagnose, cure, or treat any medical or other condition. Always seek the advice of your physician or other qualified health and ask your doctor any questions you may have regarding a medical condition. In addition to all other limitations and disclaimers in this agreement, service provider and its third party providers disclaim any liability or loss in connection with the content provided on this website.

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Needle-free injection of exosomes enable skin repair after UVB damage - MedicalResearch.com

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Stem cells are biological cells which have the ability to distinguish into specialized cells, which are capable of cell division through mitosis. Amniotic fluid stem cells are a collective mixture of stem cells obtained from amniotic tissues and fluid. Amniotic fluid is clear, slightly yellowish liquid which surrounds the fetus during pregnancy and is discarded as medical waste during caesarean section deliveries. Amniotic fluid is a source of valuable biological material which includes stem cells which can be potentially used in cell therapy and regenerative therapies. Amniotic fluid stem cells can be developed into a different type of tissues such as cartilage, skin, cardiac nerves, bone, and muscles. Amniotic fluid stem cells are able to find the damaged joint caused by rheumatoid arthritis and differentiate tissues which are damaged. Medical conditions where no drug is able to lessen the symptoms and begin the healing process are the major target for amniotic fluid stem cell therapy. Amniotic fluid stem cells therapy is a solution to those patients who do not want to undergo surgery. Amniotic fluid has a high concentration of stem cells, cytokines, proteins and other important components. Amniotic fluid stem cell therapy is safe and effective treatment which contain growth factor helps to stimulate tissue growth, naturally reduce inflammation. Amniotic fluid also contains hyaluronic acid which acts as a lubricant and promotes cartilage growth.

With increasing technological advancement in the healthcare, amniotic fluid stem cell therapy has more advantage over the other therapy. Amniotic fluid stem cell therapy eliminates the chances of surgery and organs are regenerated, without causing any damage. These are some of the factors driving the growth of amniotic fluid stem cell therapy market over the forecast period. Increasing prevalence of chronic diseases which can be treated with the amniotic fluid stem cell therapy propel the market growth for amniotic fluid stem cell therapy, globally. Increasing funding by the government in research and development of stem cell therapy may drive the amniotic fluid stem cell therapy market growth. But, high procedure cost, difficulties in collecting the amniotic fluid and lack of reimbursement policies hinder the growth of amniotic fluid stem cell therapy market.

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The global amniotic fluid stem cell therapy market is segmented on basis of treatment, application, end user and geography: Segmentation by Treatment Allogeneic Amniotic Fluid stem cell therapy Autologous Amniotic Fluid stem cell therapy Segmentation by Application Regenerative medicines Skin Orthopedics Oncology Fetal tissue reconstruction Kidney regeneration Regeneration of neural tissue Cardiac regeneration Lung epithelial regeneration Others Drug research and development Segmentation by End User Hospital Ambulatory Surgical Centers Specialty Clinics Academic and Research Institutes Segmentation by Geography North America Latin America Europe Asia-Pacific Excluding China China Middle East & Africa

Rapid technological advancement in healthcare, and favorable results of the amniotic fluid stem cells therapy will increase the market for amniotic fluid stem cell therapy over the forecast period. Increasing public-private investment for stem cells in managing disease and improving healthcare infrastructure are expected to propel the growth of the amniotic fluid stem cell therapy market.

However, on the basis of geography, global Amniotic Fluid Stem Cell Therapy Market is segmented into six key regions viz. North America, Latin America, Europe, Asia Pacific Excluding China, China and Middle East & Africa. North America captured the largest shares in global Amniotic Fluid Stem Cell Therapy Market and is projected to continue over the forecast period owing to technological advancement in the healthcare and growing awareness among the population towards the new research and development in the stem cell therapy. Europe is expected to account for the second largest revenue share in the amniotic fluid stem cell therapy market. The Asia Pacific is anticipated to have rapid growth in near future owing to increasing healthcare set up and improving healthcare expenditure. Latin America and the Middle East and Africa account for slow growth in the market of amniotic fluid stem cell therapy due to lack of medical facilities and technical knowledge.

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Some of the key players operating in global amniotic fluid stem cell therapy market are Stem Shot, Provia Laboratories LLC, Thermo Fisher Scientific Inc. Mesoblast Ltd., Roslin Cells, Regeneus Ltd. etc. among others.

The report covers exhaustive analysis on: Amniotic Fluid Stem Cell Therapy Market Segments Amniotic Fluid Stem Cell Therapy Market Dynamics Historical Actual Market Size, 2012 2016 Amniotic Fluid Stem Cell Therapy Market Size & Forecast 2016 to 2024 Amniotic Fluid Stem Cell Therapy Market Current Trends/Issues/Challenges Competition & Companies involved Amniotic Fluid Stem Cell Therapy Market Drivers and Restraints

Regional analysis includes North America Latin America Europe Asia Pacific Excluding China China The Middle East & Africa

Report Highlights: Shifting Industry dynamics In-depth market segmentation Historical, current and projected industry size Recent industry trends Key Competition landscape Strategies of key players and product offerings Potential and niche segments/regions exhibiting promising growth A neutral perspective towards market performance

Request to view TOC at https://www.persistencemarketresearch.com/toc/23101?source=atm

Read more from the original source:
Amniotic Fluid Stem Cell Therapy Market New Growth Opportunities By2018 2026 - My Health Reporter

Recommendation and review posted by Bethany Smith

The Kapamilya stars were among the first to try Belo Medical Group's latest facial treatment, the Salt Facial.

Leila Alcasid, as part of her preparations for the recently held ABS-CBN Ball 2019, had it at the Belo Beauty Suite.

Did you know she went to the ball without any make-up foundation right after she got the treatment?

Continue reading below

Other Kapamilya stars that tried this treatment before the ball were Piolo Pascual, Enrique Gil, Sue Ramirez, Heaven Peralejo, Mccoy De Leon, Barbie Imperial, and Daniella Stranner.

This three-step Salt Facial that helps "restore, replenish, and rejuvenate" the skin in an hour or less.

Dra. Vicki Belo said this treatment is perfect for those who have oily, acne-prone skin.

Continue reading below

It also has great results on minimizing wrinkles and even erasing stretch marks.

She said, "It goes to the dermal level. It uses salt, which has so many benefits for the skin, and we're bringing that machine. It's a brand new machine that we're bringing in, and we've seen amazing results for stretch marks."

Dra. Vicki and her team particularty timed the introduction of the treatment with the ABS-CBN Ball precisely to demonstrate to the stars its immediate results without skin irritation or downtime.

We chose it for the ball because, of course, we have to have calm skin for the night that will catch the light so it will reflect back and they will keep glowing.

Continue reading below

The treatment actually starts with the aesthetician cleaning the face with a cold facial cleanser that is very soothing to the skin.

This is followed by the natural sea salt exfoliation that removes dead skin cells.

Sea salt is a natural product that has anti-bacterial and anti-microbial properties, which kill pimple-causing bacteria.

The process uses a wand-like tool connected to the exfoliating machine that uses closed-loop pressure with microfine medical-grade sea salt.

The result is tighter and healthier skin that better absorbs skincare products.

Continue reading below

After this, a Mandelic or Glycolic acid will be applied on the face, depending on the client's needs. This stem cell-rich gel are massaged and infused on the skin using ultrasound technology.

The last part is the LED light therapy, which is adjusted according to the condition of the skin.

Continue reading below

Blue light is used to minimize inflammation and kill acne-causing bacteria. Meanwhile, red light promotes collagen production and also helps promote healing.

Dra. Vicki said that it also comes in green for pigmentation.

Immediate results can be noticed after the treatment. The skin feels softer, and glowing in an instant.

The Salf Facial will soon be available at Belo Clinics nationwide.

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Leila Alcasid's facial can dry acne fast in just one session - Philippine Entertainment Portal

Recommendation and review posted by Bethany Smith

Stem cells are biological cells which have the ability to distinguish into specialized cells, which are capable of cell division through mitosis. Amniotic fluid stem cells are a collective mixture of stem cells obtained from amniotic tissues and fluid. Amniotic fluid is clear, slightly yellowish liquid which surrounds the fetus during pregnancy and is discarded as medical waste during caesarean section deliveries. Amniotic fluid is a source of valuable biological material which includes stem cells which can be potentially used in cell therapy and regenerative therapies. Amniotic fluid stem cells can be developed into a different type of tissues such as cartilage, skin, cardiac nerves, bone, and muscles. Amniotic fluid stem cells are able to find the damaged joint caused by rheumatoid arthritis and differentiate tissues which are damaged. Medical conditions where no drug is able to lessen the symptoms and begin the healing process are the major target for amniotic fluid stem cell therapy. Amniotic fluid stem cells therapy is a solution to those patients who do not want to undergo surgery. Amniotic fluid has a high concentration of stem cells, cytokines, proteins and other important components. Amniotic fluid stem cell therapy is safe and effective treatment which contain growth factor helps to stimulate tissue growth, naturally reduce inflammation. Amniotic fluid also contains hyaluronic acid which acts as a lubricant and promotes cartilage growth.

With increasing technological advancement in the healthcare, amniotic fluid stem cell therapy has more advantage over the other therapy. Amniotic fluid stem cell therapy eliminates the chances of surgery and organs are regenerated, without causing any damage. These are some of the factors driving the growth of amniotic fluid stem cell therapy market over the forecast period. Increasing prevalence of chronic diseases which can be treated with the amniotic fluid stem cell therapy propel the market growth for amniotic fluid stem cell therapy, globally. Increasing funding by the government in research and development of stem cell therapy may drive the amniotic fluid stem cell therapy market growth. But, high procedure cost, difficulties in collecting the amniotic fluid and lack of reimbursement policies hinder the growth of amniotic fluid stem cell therapy market.

Get Full Report Overview at https://www.persistencemarketresearch.com/market-research/amniotic-fluid-stem-cell-therapy-market.asp

The global amniotic fluid stem cell therapy market is segmented on basis of treatment, application, end user and geography: Segmentation by Treatment Allogeneic Amniotic Fluid stem cell therapy Autologous Amniotic Fluid stem cell therapy Segmentation by Application Regenerative medicines Skin Orthopedics Oncology Fetal tissue reconstruction Kidney regeneration Regeneration of neural tissue Cardiac regeneration Lung epithelial regeneration Others Drug research and development Segmentation by End User Hospital Ambulatory Surgical Centers Specialty Clinics Academic and Research Institutes Segmentation by Geography North America Latin America Europe Asia-Pacific Excluding China China Middle East & Africa

Rapid technological advancement in healthcare, and favorable results of the amniotic fluid stem cells therapy will increase the market for amniotic fluid stem cell therapy over the forecast period. Increasing public-private investment for stem cells in managing disease and improving healthcare infrastructure are expected to propel the growth of the amniotic fluid stem cell therapy market.

However, on the basis of geography, global Amniotic Fluid Stem Cell Therapy Market is segmented into six key regions viz. North America, Latin America, Europe, Asia Pacific Excluding China, China and Middle East & Africa. North America captured the largest shares in global Amniotic Fluid Stem Cell Therapy Market and is projected to continue over the forecast period owing to technological advancement in the healthcare and growing awareness among the population towards the new research and development in the stem cell therapy. Europe is expected to account for the second largest revenue share in the amniotic fluid stem cell therapy market. The Asia Pacific is anticipated to have rapid growth in near future owing to increasing healthcare set up and improving healthcare expenditure. Latin America and the Middle East and Africa account for slow growth in the market of amniotic fluid stem cell therapy due to lack of medical facilities and technical knowledge.

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Some of the key players operating in global amniotic fluid stem cell therapy market are Stem Shot, Provia Laboratories LLC, Thermo Fisher Scientific Inc. Mesoblast Ltd., Roslin Cells, Regeneus Ltd. etc. among others.

The report covers exhaustive analysis on: Amniotic Fluid Stem Cell Therapy Market Segments Amniotic Fluid Stem Cell Therapy Market Dynamics Historical Actual Market Size, 2012 2016 Amniotic Fluid Stem Cell Therapy Market Size & Forecast 2016 to 2024 Amniotic Fluid Stem Cell Therapy Market Current Trends/Issues/Challenges Competition & Companies involved Amniotic Fluid Stem Cell Therapy Market Drivers and Restraints

Regional analysis includes North America Latin America Europe Asia Pacific Excluding China China The Middle East & Africa

Report Highlights: Shifting Industry dynamics In-depth market segmentation Historical, current and projected industry size Recent industry trends Key Competition landscape Strategies of key players and product offerings Potential and niche segments/regions exhibiting promising growth A neutral perspective towards market performance

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Read more:
Amniotic Fluid Stem Cell Therapy Market to Create Lucrative Opportunities for Existing Companies as Well as New Players - Herald Space

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Stromal vascular fraction skin treatment is a type of stem cell therapy based on isolation of adipose tissue during liposuction or lipo-aspiration procedures of patients own body. In stromal vascular fraction treatment isolation of tissue contains fat cells, blood cells, and endothelial cells, as well as a large fraction of adipose-derived mesenchymal stem cells which provides regenerative properties and have positive anti-aging properties. A stromal vascular fraction is considered as a personalized stem cell therapy and effective tropical or injectable treatment.

With increasing age, regenerative and repair properties of skin are less effective due to decrease in stem cell count, and therefore, stromal vascular fraction treatment contains stem cell provides a boost in repair and maintenance mechanism of the skin leaving smooth, healthy, radiant skin. Stromal vascular fraction is a naturally occurring stem cell found in bundles of adipose tissues and are the primary source of growth factors along with macrophages and other cells. Due to the presence of growth factors, the stromal vascular fraction is utilized to decrease inflammation present in many diseases. A stromal vascular fraction is adopted in the treatment of rheumatoid arthritis, joint replacement, osteoarthritis, diabetes, Crohn's disease, and others.

Stromal Vascular Fraction Market: Overview

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Stromal vascular fraction is a combination of adipose-derived stromal cells (ADSCs), endothelial cells (ECs), endothelial precursor cells (EPCs), smooth muscle cells, macrophages, pericytes, and pre-adipocytes in the aqueous state. Stromal vascular fraction is advantageous over alternative medical treatments as SVF has the ability to regulate patients own system with the main focus on cell repair and regulation of defective cells. Stromal vascular fraction is a promising field for disease prophylaxis and currently are in clinical trials.

The research report presents a comprehensive assessment of the market and contains thoughtful insights, facts, historical data, and statistically supported and industry-validated market data. It also contains projections using a suitable set of assumptions and methodologies. The research report provides analysis and information according to categories such as market segments, geographies, types, technology and applications.

The report covers exhaustive analysis on: Market Segments Market Dynamics Market Size Supply & Demand Current Trends/Issues/Challenges Competition & Companies involved Technology Value Chain

Stromal Vascular Fraction Market: Segmentation

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The globalstromal vascular fraction marketcan be segmented on the basis of type of therapy, end-user, and region.

By Therapy Type SVF Isolation Products Enzymatic Isolation Non-enzymatic Isolation Automated POC Devices SVF Aspirate Purification Products SVF Transfer Products

By End-user Hospitals Specialty Clinics Stem Cell Banks/Laboratories Others

By Application Cosmetic Soft-tissue Orthopedic Others

By Region North America Latin America Europe Asia Pacific (APAC) South Korea Middle East and Africa (MEA)

In its last part, the report offers insights on the key players competing in the global market for stromal vascular fraction. With detailed profiling of each of the key companies active on the competitive landscape, the report provides information about their current financial scenario, revenue share at a global level, development strategies, and future plans for expansion. Strategic collaborations, mergers, and acquisitions have also been considered as a key strategy among a majority of leading companies in the market.

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Originally posted here:
Stromal Vascular Fraction Market by Top Key Players, Size, Subdivision & Market Dynamics Forces - Commerce Gazette

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Everyone has heard of the seven wonders of the ancient world. Today I present my verdict on seven wonder discoveries in biological research, listed in rough chronological order.

Wonder 1: Cell TheoryCell theory, formulated in 1839, made three assertions: (a) All organisms are composed of basic units called cells; (b) The cell is the basic unit of structure and organisation in all living organisms; (c) New cells arise only from pre-existing cells.

Cell theory rationalised basic biology and contradicted the common notion that life can arise spontaneously from non-living matter.

Wonder 2: The Theory of Evolution Through Natural Selection.This is the most significant-ever insight into biology and was jointly proposed in 1858 by Charles Darwin (1809-1882) and Alfred Russell Wallace (1823-1913). It was already known that life on earth changes over long time periods. The theory of evolution explained the mechanism underpinning these changes natural selection. This theory draws all biology together into one unified framework. In its absence, biology would be reduced to a vast catalogue of unrelated observations.

Wonder 3: The Chemistry of LifeLife, unlike mechanical machines, works close to room temperature and without the assistance of significant temperature or pressure gradients. How then do cells grow, divide and create local order in a world that otherwise moves towards increasing disorder? This question was answered by biochemistry the chemistry of life.

A living cell is the end product of co-ordinated reactions between its innumerable chemical constituents metabolism. These reactions must proceed fast enough at room temperature to sustain life, and this is enabled by protein catalysts called enzymes, discovered in the 1800s. Cell metabolism is driven by energy, ultimately supplied by sunlight.

Wonder 4: Antibiotics and VaccinationsAntibiotics, discovered in 1928, are used to kill pathogenic microbes, and vaccination to provide immunity against disease has been in widespread use since 1900. Vaccination has eliminated many deadly diseases, including smallpox and polio.

Average life expectancy in 1900 was 50 years; today that figure is 82 years. Antibiotics and immunisation are one significant cause of this improvement. If we lost antibiotics and vaccinations today, life expectancy would gradually revert to 50-60 years.

Wonder 5: Discovering the Structure of DNAFaithful inheritance of parental characteristics by offspring is essential for biological evolution. The nature of the cells hereditary material was identified as nucleic acid (DNA) in 1944. In 1953, James Watson (born in 1928) and Francis Crick (1916-2004) made the greatest biological discovery of the 20th century when they solved the structure of DNA, a discovery that also indicated how DNA replicates and transmits genetic information from generation to generation.

DNA is a long molecule made of four sub-units A,T,G,C. Genetic information is encoded in the linear sequence (genes) of these subunits, dictating the structure/activity of all cell proteins, including all enzymes, thereby controlling the activities of the cell. Understanding DNA unlocked the secret of the molecular logic of life.

Wonder 6: CloningEvery animal body cell, including cells of the early embryo, contains a full set of the animals genes. Therefore, inducing any body cell into developing as embryonic cells develop should produce a genetic copy of the animal a clone. In 1996 Dolly the sheep was cloned in this manner.

Cloning offers many huge potential benefits, eg cloning animals, genetically modified to secrete a human hormone, to produce herds secreting large quantities of the hormone for use by patients deficient in the hormone. Cloning could also rebuild endangered animal populations or revive extinct animals.

Wonder 7: Induced Pluripotent Stem CellsThe human body is composed of over 200 tissues/organs skin, liver etc. Each tissue cell is differentiated to do a particular job. But all tissue cells develop from embryonic undifferentiated pluripotent stem cells.

In 2006 Shinya Yamanaka discovered how to transform differentiated body cells into pluripotent stem cells. These induced pluripotent stem cells (IPSC) can be coaxed to develop into specific adult tissues.

IPSCs have huge potential in many areas, eg regenerative medicine. New organs could be grown from patients own IPSCs to replace failing organs and without fear of immune rejection.

IPSCs are extremely useful for many research purposes, eg testing new drugs, and can substitute for stem cells extracted from human embryos, thereby avoiding ethical problems.

William Reville is an emeritus professor of biochemistry at UCC

See more here:
Story of life: Seven wonders of biological research - The Irish Times

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Cancer stem cells (CSCs) refer to the cells obtained from tumor that posses potential to reproduce all types of cancer cells found in a cancer sample. Cancer stem cells are planned to grow in tumors as a separate population and thereby cause deterioration and metastasis of existing tumor through generation of new tumor. Thus, with advancement in technology especially in cancer stem cells research area, therapies specific to targeting cancer stem cells are expected to improve quality of life and survival cases of cancer patients with metastatic diseases.

Morbidity and mortality rate of cancer is rising at a faster speed worldwide and thus prevention of cancer and cancer treatment is grabbing attention of cancer researchers globally. Stem cells and cell therapy have shown significant potential to treat cancer effectively. Cancer stem cells (CSCs) have been tested on animal models and have also shown satisfactory results. However, human testing of cancer stem cells is still in its developing stage owing to stringent regulations and ethical issues associated with the same.

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Worldwide cancer research activities are increasing rapidly owing to rising burden of mortality rate of cancer. Cancer stem cells are under research for various types of cancers such as lung cancer, breast cancer, colorectal cancer, skin cancer, brain cancer and bone cancer. Government initiative to boost the cancer research activities and availability of funds are some of the factors that are driving the global cancer stem cells (CSCs) market towards growth. While on the other hand, ethical issues involved in the stem cells research and stringent regulations to perform human trials are some of the factors that are restraining the growth of the global cancer stem cells (CSCs) market.

Geographically, global cancer stem cells market is segmented into North America, Europe, Asia Pacific and Rest of the world (RoW) regions. Currently, North America is leading the global cancer stem cells (CSCs) market and is followed by Europe. Factors such as highly developed research infrastructure, well defined regulatory norms, availability of research funds, availability of skilled research and healthcare professionals and supportive economy are driving the North American cancer stem cells market towards growth. Asia Pacific is lucrative market for cancer stem cells. Governments in the Asia Pacific countries mainly, India and China are taking initiative to boost the healthcare and biotechnology industry in the respective countries and thus, research and development activities in these countries are swiftly increasing.

Apart from India and China, Japan will play a significant role in the cancer stem cells market. Japanese government is heavily investing in healthcare industry in order to improve the healthcare facilities in the country and thus rising cancer treatment are expected to escalate the cancer stem cells treatment market in Japan. Latin American countries namely, Brazil, Mexico and Argentina are expected to contribute more to cancer stem cells market than other countries in the rest of the world region. While on the other hand, African countries and Middle Eastern countries are expected to show slow or no growth rate in the global cancer stem cells (CSCs) market.

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Some of the major players in the global cancer stem cells market are AdnaGen GmbH, Advanced Cell Diagnostics, Inc., AVIVA Biosciences Corporation, Celula, Inc., Epic Sciences, Inc., Fluxion Biosciences, Inc., Rarecells USA, Inc. and Silicon Biosystems, S.p.A.

This research report analyzes this market on the basis of its market segments, major geographies, and current market trends. Geographies analyzed under this research report include North America Asia Pacific Europe Rest of the World

This report provides comprehensive analysis of Market growth drivers Factors limiting market growth Current market trends Market structure Market projections for upcoming years

This report is a complete study of current trends in the market, industry growth drivers, and restraints. It provides market projections for the coming years. It includes analysis of recent developments in technology, Porters five force model analysis and detailed profiles of top industry players. The report also includes a review of micro and macro factors essential for the existing market players and new entrants along with detailed value chain analysis.

Reasons for Buying this Report This report provides pin-point analysis for changing competitive dynamics It provides a forward looking perspective on different factors driving or restraining market growth It provides a six-year forecast assessed on the basis of how the market is predicted to grow It helps in understanding the key product segments and their future It provides pin point analysis of changing competition dynamics and keeps you ahead of competitors It helps in making informed business decisions by having complete insights of market and by making in-depth analysis of market segments It provides distinctive graphics and exemplified SWOT analysis of major market segments

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Read more:
Cancer Stem Cells Market to Increase at Steady Growth Rate 2016-2024 - The Check Chronicle

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