Genetics Part 4 Mutations
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Dixie Kong #39;s Double Trouble: Just Genetics - PART 6 - Grumpcade
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Fmr. Firefighter Gets Some Help From #39;Vanilla Ice #39;
A former firefighter and paramedic hopped into his brand new pool specially designed for him after a spinal cord injury and he had some ice too. Subscribe now to CBS Miami for more updates:...

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The ABCs of Parenting with a Spinal Cord Injury
Parenting is never a breeze, but parenting with a spinal cord injury can present additional and unique challenges. Find out how others with SCI have met these challenges in this panel discussion...

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3 hours ago by Denis Paiste MIT biological engineering graduate student Frances Liu works with a spiral-shaped inertial microfluidic separation device for separating stem cell populations in the Laboratory for Material Chemomechanics at MIT. This device was adapted from previous designs to separate cells as a function of diameter. Liu also grows bone marrow-derived stem cells and studies how those stem cells release certain chemicals in response to mechanical interactions with materials in the surrounding environment. Credit: Denis Paiste/Materials Processing Center

Researchers in MIT Associate Professor Krystyn J. Van Vliet's group last year showed that three biomechanical and biophysical markers could accurately identify the most desirable stem cells from a mixed group of bone marrow-derived cells. Now, MIT biological engineering graduate student Frances Liu is trying to advance that work by understanding how to alter the stem cells' physical environment to get them to produce the most desirable chemical output.

The bone marrow cells secrete special chemicals called cytokines that are needed in the body to repair bone tissue, fat tissue, and connective tissue like cartilage. "These so-called factors that the cells produce are associated with those tissue growth functions and tissue repair functions," Van Vliet says.

Liu grows bone marrow-derived stem cells and studies how those stem cells release certain chemicals in response to mechanical interactions with materials in their surrounding environment. "I would like to manipulate the cells, using cell-material interactions, or synthetic materials, to produce certain chemicals beneficial to tissue repair," Liu explains in the Laboratory for Material Chemomechanics at MIT. "Right now we are in the characterization phase, quantifying which and how much of different cytokines the cells secrete in response to different chemical and mechanical cues that we provide. Down the line, we aim to engineer those cytokine profiles using cell-material interactions." Liu, 24, is a third-year PhD student and expects to complete her doctorate in 2017. She received her bachelor of science degree in biomedical engineering from Brown University.

Liu is examining how various groups of stem cells differ in response to lab-controlled changes in their environment in ways that might be important for tissue repair in the body. "Frances is determining the correlations between the mechanical properties of the materials the cells interact with and the chemical factors that they produce in response to that chemomechanical coupling," Van Vliet says.

Heterogeneous cellular factories

"You can think of the cells as factories; they're factories of chemicals," Van Vliet explains. "One of the main ways you change the way that factory operates is you change the material properties of its environment. How stiff that environment is, how acidic that environment is, how rough that environment is, all of those characteristics of the cell's outside world can directly correlate with the chemicals that that cell produces. We don't really understand all of why that happens yet, but part of Frances' thesis is to understand these particular stem cells and the subpopulations within them."

While other researchers previously studied mechanical factors such as stiffness on the function of these mesenchymal (bone marrow-derived) stem cells, it wasn't widely recognized that they were examining a mixed population of cells, not a single well-defined cell population. "Some of them were stem cells, but some were not," Van Vliet says.

One way that Liu sorts her stem cells into groups is using an inertial microfluidic separation device that separates cells of large diameter cells from those of small diameter. This device was adapted from previous designs of their collaborator, MIT Professor Jongyoon Han, as part of the interdisciplinary team that Van Vliet leads within the Singapore-MIT Alliance for Research and Technology (SMART). The group showed in a 2014 paper that three markerssize, mechanical stiffness, and how much the nucleus inside the cell moves aroundare sufficient to identify stem cells in a heterogeneous population of chemically similar but non-stem cells. "We measured those three properties as well as several other properties, but only those three properties together, that triplet of properties, distinguished a stem cell from a non-stem cell," Van Vliet says.

By using the microfluidic device, we can better understand the differences between the subpopulations of these heterogeneous bone marrow cells and which cytokines each subpopulation may be secreting, both in the body and in the lab.

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Altering mechanical properties of cell environments to produce desired chemical outputs

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FREDERICK, Md., March 23, 2015 /PRNewswire-USNewswire/ --Recent studies employing adult stem cells obtained from bone marrow and fat have been used in patients suffering from osteoarthritis of the knee. Results have indicated not only symptomatic improvement but also suggest that cartilage healing and regeneration may be taking place.

According to Director, Dr. Nathan Wei of the Arthritis Treatment Center, "Osteoarthritis options in the past have been limited to symptom relief. We are now entering an era where we have therapies that may also rebuild lost cartilage."

Osteoarthritis (OA) of the knee affects more than 20 million Americans. It is a disease due to loss of cartilage, the gristle that caps the ends of long bones and provides cushioning and shock absorption.

He goes on to say, "by administering adult stem cells, in a certain fashion, we may be able to restore lost cartilage. While this action has been demonstrated in multiple animal models, it has only been described in anecdotal reports in humans. Fortunately, we are now conducting clinical studies that are much better controlled and more scientifically valid."

Dr. Wei adds, "The positive effect on arthritis is not only due to multiplication, division, and transformation of the stem cell into cartilage, but it is also due to the fact the stem cell releases proteins that attract other reparative cells to the area. This is called the 'paracrine' effect."

"We are excited about the early results of our investigation and hope the results will continue to be positive. If so, I hope that knee replacement surgery might become a thing of the past," he concludes.

Dr. Wei is a board-certified rheumatologist and regenerative medicine expert. He is director of the Arthritis Treatment Center located in Frederick, Maryland.

http://www.arthritistreatmentcenter.com

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Stem cell treatment for knee arthritis shows promising results

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stem cell therapy Jakarta tangerang serpong bsd bintaro
http://youtu.be/E-XmebCWfKs.

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What is "Stem cell therapy" ? | Steps in PRP Treatment : TV5 News
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Bone Cancer - Chondrosarcoma 3 weeks after Surgery
stem cell india, stem cell therapy india, stem cell in india, stem cell therapy in india, india stem cell, india stem cell therapy, Chondrosarcoma, Bone Cancer.

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Las Vegas, Nevada (PRWEB) March 23, 2015

Nevada Pain, the top pain management clinics in Las Vegas and Henderson areas, are now offering stem cell therapy to help patients delay or avoid the need for joint replacement. The treatments are cutting edge, outpatient, and highly effective. Call (702) 323-0553 for more information and scheduling.

Stem cell therapy for joint arthritis has rapidly become mainstream due to its effectiveness for pain relief. Unlike traditional treatments, the regenerative medicine therapies actually have the potential to change the course of arthritis rather than simply provide a proverbial "band aid" to the condition.

The stem cell treatments are provided by Board Certified, Fellowship Trained pain doctors who have extensive experience with the procedures into all extremity joints including the hip, knee, shoulder and ankle. There are multiple types of stem cell treatments. Some involve amniotic fluid derived treatment, which contains an immense amount of stem cells, growth factors, hyaluronic acid and anti-inflammatory mediators as well.

Bone marrow derived treatment is also available, which also contains an immense amount of stem cells and growth factors. The treatments are provided as an outpatient, and often provide pain relief and functional improvement.

Platelet Rich Plasma Therapy is also offered, which involves a simple blood draw. The platelets are then concentrated and immediately injected into the problem area.

For more information and scheduling with the top regenerative medicine clinic in Las Vegas, call (702) 323-0553.

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Nevada Pain Now Offering Stem Cell Therapy to Help Patients Delay or Avoid Joint Replacement

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Are Genetically Modified Foods Safe to Eat? (Science of Genetic Engineering)
Presented by Anastasia Bodnar PhD. In a recent Pew poll, 88% of AAAS scientists said that genetically engineered crops were safe to eat. In contrast, only 37% of non-scientists surveyed said...

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Tom Horn End Time Sings Mixing Human DNA With Animal DNA Audio only
Audio Only 2015 August Breaking News Mixing Human DNA with Animal DNA - Last Days End Times News Prophecy Update - Genetic Engineering.

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45 minutes ago by Robert Sanders The bacterial enzyme Cas9 is the engine of RNA-programmed genome engineering in human cells. Credit: Jennifer Doudna/UC Berkeley

A group of 18 scientists and ethicists today warned that a revolutionary new tool to cut and splice DNA should be used cautiously when attempting to fix human genetic disease, and strongly discouraged any attempts at making changes to the human genome that could be passed on to offspring.

Among the authors of this warning is Jennifer Doudna, the co-inventor of the technology, called CRISPR-Cas9, which is driving a new interest in gene therapy, or "genome engineering." She and colleagues co-authored a perspective piece that appears in the March 20 issue of Science, based on discussions at a meeting that took place in Napa on Jan. 24. The same issue of Science features a collection of recent research papers, commentary and news articles on CRISPR and its implications.

"Given the speed with which the genome engineering field is evolving, our group concluded that there is an urgent need for open discussion of the merits and risks of human genome modification by a broad cohort of scientists, clinicians, social scientists, the general public and relevant public entities and interest groups," the authors wrote.

Doudna, director of UC Berkeley's Innovative Genomics Initiative, was joined by five current and two former UC Berkeley scientists, plus David Baltimore, a Nobel laureate and president emeritus of the California Institute of Technology, Stanford Nobelist Paul Berg and eminent scientists from UC San Francisco, Stanford, Harvard and the universities of Wisconsin and Utah. Several of these scientists are currently involved in gene therapy to cure inherited diseases.

Latest of many warnings

Such warnings have been issued numerous times since the dawn of genetic engineering in 1975, but until now the technology to actually fix genetic defects was hard to use.

"However, this limitation has been upended recently by the rapid development and widespread adoption of a simple, inexpensive and remarkably effective genome engineering method known as CRISPR-Cas9," the scientists wrote. "The simplicity of the CRISPR-Cas9 system enables any researcher with knowledge of molecular biology to modify genomes, making feasible many experiments that were previously difficult or impossible to conduct."

Correcting genetic defects

Scientists today are changing DNA sequences to correct genetic defects in animals as well as cultured tissues generated from stem cells, strategies that could eventually be used to treat human disease. The technology can also be used to engineer animals with genetic diseases mimicking human disease, which could lead to new insights into previously enigmatic disorders.

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Scientists have found that genetic changes in bowel tumors are linked to the way the body's immune system responds to the cancer, according to research published in the journal Oncoimmunology.

For the first time, Cancer Research UK researchers at the University of Birmingham have found that certain genetic flaws in bowel cancer are more likely to trigger an immune response at the site of tumors, meaning that treatments to boost this immune response further could potentially be helpful for these patients.

Finding out what's happening in a cancer patient's immune system can be difficult and takes time. These findings suggest that genetic profiles of patients' tumors could be used as an easy and fast way of diagnosing whether they are suitable for immunotherapy treatments, and if so which ones.

Cancer Research UK's FOCUS4 trial is already using the genetics of bowel cancer to offer patients stratified medicine and this study suggests that we could further expand this work to include immunotherapies.

Gary Middleton, Professor of Medical Oncology at the School of Cancer Sciences at the University of Birmingham, said: "The field of immunotherapy is gaining lots of momentum and this study shows a new finding for bowel cancer. We are already using genetic profiling for stratified medicine in bowel cancer in the FOCUS4 trial. But this research indicates that we could marry immunotherapy with the work we are already doing to personalize treatment even more."

Researchers used The Cancer Genomic Atlas, a large database, to study this relationship. From this research, scientists can now start looking at what causes a weak immune response and in the future, could target drugs to switch off the immune suppression associated with certain genetic mutations.

Nell Barrie, senior science communication manager at Cancer Research UK, said: "This study shows a strong association between certain genetic profiles and immune responses, but we don't yet fully understand this link. Further research to investigate the fundamentals behind different immune responses could open new doors in drug development."

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The above story is based on materials provided by Cancer Research UK. Note: Materials may be edited for content and length.

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New potential for personalized treatments in bowel cancer

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Introduction to blood type genetics problems/multiple alleles
If you were absent for our discussion on this topic, please watch and fill out your worksheet as you watch.

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Spring Fling Genetics Seminar International Panel
Spring Fling Genetics Seminar International Panel: Jan DeVries, AI Total, Declan Patten, Australia, and Paul Hunt, Alta Genetics. The International Panel took the stage to answer questions...

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Truth or Myth - Are all mutations really harmful? (LS 2G03 Minute Genetics Presentation)
LS 2G03 OneMinute Genetics.

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Truth or Myth - Are all mutations really harmful? (LS 2G03 Minute Genetics Presentation) - Video

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Aqw Guild genetics - tutorial
Just complete the quest in the room with drakath, then that should gain access to the next room. And you might wanna use a good Farming class as well. other then that your good to go....

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It isn't that often that a scientific controversy is featured in the New Yorker, but in 2012 an article titled "Kin and Kind" (http://www.newyorker.com/magazine/2012/03/05/kin-kind) describing a tempest over a biological theory appeared in its pages.

The tempest was provoked by an article in the Aug. 26, 2010 issue of Nature. Written by Harvard mathematicians Martin A. Nowak and Corina E. Tarnita and Harvard biologist Edward O. Wilson, it questioned the validity of the theory of inclusive fitness.

Inclusive fitness theory, proposed by British biologist W. D. Hamilton in 1964, expanded Darwin's definition of "fitness" -- an organism's success in passing on its genes -- to include the genes of its relatives. This expansion made altruism in the service of kin a competitive strategy.

The Nature article, titled "The Evolution of Eusociality," asserted that inclusive fitness theory, which has been a cornerstone of evolutionary biology for the past 50 years, had produced only "meagre" results and that mathematical models based on standard natural selection theory provide a "simpler and superior approach."

This provoked a prolonged argument among evolutionary biologists that is still not resolved. But in the March 31 issue of PLOS Biology David C. Queller, PhD, a well-known evolutionary biologist at Washington University in St. Louis, suggests a way out of the impasse.

Queller, the Spencer T. Olin Professor in the Department of Biology, and his co-authors Stephen Rong, who graduated from Washington University with a bachelor's degree in math and is now a graduate student at Brown University, and Xiaoyun Liao, a former research assistant at Rice University with expertise in mathematical modeling, adopted the model the Harvard writers had proposed as an alternative to inclusive fitness and tested it to see whether it supported the claims the authors made in the Nature paper.

It didn't. "They had a modeling strategy that should work and should be fine, but they weren't careful enough when they made claims about their models' novel results," Queller said. But he also argued that the two mathematical models are essentially equivalent in that they ultimately predict the same results.

Inclusive fitness and social insects

Inclusive fitness was originally developed to explain eusociality, a extreme form of altruism found in social insects, where non-reproducing colony members give up their right to reproduce and devote their lives to caring for the offspring of a single reproducing member.

Hamilton's inclusive fitness theory was invented to solve this paradox, which vexed even Darwin. Hamilton calculated that sterile castes could evolve if altruistic sterility sufficiently benefited relatives also carrying the altruistic gene.

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genetics of altruism: Is blood really thicker than water?

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Stemedix Patient Experience - Debra F. Multiple Sclerosis (RRMS)
Debra F. talks about her experience with Stemedix (http://stemedix.com) Stem Cell Therapy in the United States 24 hours after her initial treatment. Stemedix provides Adipose derived stem cell...

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Top Features Psychedelic Drug Use Could Reduce Psychological Distress, Suicidal Thinking

A history of psychedelic drug use is associated with less psychological distress and fewer suicidal thoughts, planning, and attempts, according to new research from Johns Hopkins and the University of Alabama at Birmingham.

Researchers at Johns Hopkins have successfully corrected a genetic error in stem cells from patients with sickle cell disease, then used those cells to grow mature red blood cells.

When and why do physicians prescribe costlier brand-name drugs when generic ones are available? Thats the question the Food and Drug Administration has put to a Johns Hopkins team, which has been tapped to conduct a two-year study that will analyze factors that determine underuse of generic drugs.

Even though the ORC protein machinery is crucial to life, we didnt know much about how it works, says James Berger, Ph.D. By learning what it looks like, down to the arrangement of each atom, we can get a sense of where it interacts with DNA and how it does its job.

At noon on Friday, March 20, fourth-year medical students from the Johns Hopkins University School of Medicine and all across the country learned where they will begin residency programs this summer. Meet five remarkable medical students and learn what brought them to call Johns Hopkins their home.

Dr. Saleh Alqahtani discusses the causes, symptoms and treatment of nonalcoholic fatty liver disease.

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Researcher Hongjun Song introduces the Stem Cell Biology Program, where scientists get an up-close look at diseases by making stem cells with patients' DNA and growing affected cell types in the lab.

Watch on YouTube

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Johns Hopkins Medicine, based in Baltimore, Maryland

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What is "Stem cell therapy" ? | Steps in PRP Treatment : TV5 News
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Research with Fruit Flies?
Ross Cagan discusses different cancer therapies and his specific research on personalized medicine using fruit flies. He also describes how his grant from the American Cancer Society has helped...

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Research with Fruit Flies? - Video

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Personalized Medicine on the Today Show
Medical Lab Reps Wanted http://LabRepsWanted.com Carl France (208) 514-8374.

By: Carl France

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Horizon Discovery: The Power of Personalized Medicine
Learn about how Personalized Medicine is changing how drugs are being developed and how healthcare is being delivered, and how Horizon is helping to enable this change. Powering Genomic ...

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